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BACKGROUND The aim of this study was to determine the association between white matter lesions (WML) and diabetes-associated cognitive decline (DACD) in rat models of type 2 diabetes (T2DM). MATERIAL AND METHODS Sixty Sprague-Dawley male rats were divided into 4 groups: control, control+metformin, T2DM, and T2DM+metformin groups. The T2DM groups were fed a diet high in fat and glucose to induce impaired glucose tolerance (IGT) and then were injected with streptozotocin to induce T2DM. The Morris water maze test was used to evaluate cognitive function. Brain diffusion tensor imaging scans were performed for WML. The expression of myelin basic protein (MBP), oligodendrocyte transcription factor 1 (OLIG1), and OLIG2 (markers of brain damage and repair) was determined using immunofluorescence. After IGT, the fractional anisotropy (FA) values of the right thalamus area were significantly lower in both T2DM groups compared with controls. RESULTS Eight weeks after streptozotocin injection, the FA values of the thalamus were lower in the T2DM (bilateral thalamus) group and T2DM+metformin (left thalamus) group than in controls, while the FA values in the left thalamus area were lower in the T2DM+metformin group than in the control and control+metformin groups. The maze escape latency was longer and the number of rats passing through the platform was smaller in the T2DM and T2DM+metformin groups than in the control group. MBP levels were lower and OLIG1 and OLIG2 levels were higher in both T2DM groups than in controls. CONCLUSIONS WML is associated with DACD and appears before the onset of T2DM and signs of DACD and plays a role in diabetes-associated cognitive decline. Metformin reduces WMLs but does not rescue cognitive dysfunction.

With the rapid development of Internet technology, the spread of information and the arrival of the big data era, data security is becoming more and more important, in the process of data transmission is to solve the first problem of identification and data privacy of both sides, these problems have to rely on cryptography to solve, but with the explosive growth of Internet users in recent years, the traditional PKI/CA public key password system due to the management of certificates cumbersome and complex use, gradually exposed its shortcomings. In a password system that uses an identity password algorithm, the consumer has a meaningful and unique identity, which is itself the public key of the entity. Without the need to pre-negotiate keys or exchange certificates, the time it takes to apply and validate in a traditional certificate system can be significantly reduced and easy to use. This paper is mainly based on the Description of the SM9 digital signature algorithm based on the sM9 logo password national standard “GM/T 0044 SM9 logo password algorithm”, and uses C language programming to realize the complete process of SM9 digital signature algorithm. The implementation process is divided into parameter settings, key generation, digital signature generation, signature verification four core steps. This design mainly provides the function of selecting its own identity key generation, digital signing of message, signature verification, and has the advantages of simple operation and high efficiency.

A thermo-elastic-plastic numerical method based on the hybrid inversion combing experiment results and numerical results was developed. The influence of various factors in the welding process on the welding deformation and residual stress was taken into account through the equivalent heat source parameter (EHSP). The out-of-plane displacement and residual stress of the butt-welded plate were measured firstly with electrical measurement method and hole-drilling method respectively. Then, a function was established to evaluate the standard error (SE) employing different heat source parameters between numerical and experimental results, and the EHSP corresponding to SEmin for the current material and welding conditions was inversed. At last, the EHSP was applied to the investigation of welding sequence. This method is also suitable for other welding methods and weld types.

A novel kind of bend resistant large mode area fiber is proposed. With the introduce of a multi-layer core, this kind of fiber breaks the mode field area limitation for multi-trench fiber, and achieves a mode filed area of 1300 μm2 at a bend radius of 15cm.

Complement C1q tumor necrosis factor-related protein 1 (CTRP1), an adipose tissue-derived adipokine has been shown to decrease blood glucose levels and to improve metabolism of glucose in mice. In addition, CTRP1 has exhibited significant association with BMI, adiponectin and TNF-α in diabetic animal models. However, there are no published studies addressing CTRP1 levels in type 2 diabetic patients. Therefore, it was of interest to evaluate plasma CTRP1 levels and associated clinical parameters and biomarkers in patients with type 2 diabetes. 135 subjects were recruited to this study, including 62 type 2 diabetic patients (DM group) and 73 healthy subjects (control group). We measured biochemical parameters, CTRP1, TNF-α and adiponectin using enzyme-linked immunosorbent assay (ELISA). Plasma CTRP1 levels showed a significant difference between the DM group and the control group (646.3 ± 154.4 ng/mL vs. 442.6 ± 165.4 ng/mL, p < 0.01). In addition, CTRP1 was strongly positively associated with BMI, glucose levels, HbA1c, HOMA-IR and TNF-α in diabetic patients. CTRP1 showed negative correlation with adiponectin. In Multivariate regression analysis, CTRP1 was strongly independently associated with diabetes when CTRP1 levels were analyzed by both as a continuous variable and quartile (OR: 1.009, 95% CI: 1.004-1.015, p < 0.05; OR: 2.443, 95% CI: 1.379-4.182, p < 0.01, respectively). Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state.