229 results on '"Ding, Xu"'
Search Results
2. Jamming-Assisted Legitimate Eavesdropping and Secure Communication in Multicarrier Interference Networks
- Author
-
Hongbo Zhu and Ding Xu
- Subjects
021103 operations research ,Computer Networks and Communications ,business.industry ,Computer science ,0211 other engineering and technologies ,Jamming ,Eavesdropping ,02 engineering and technology ,Transmitter power output ,Interference (wave propagation) ,Computer Science Applications ,Constraint (information theory) ,Secure communication ,Control and Systems Engineering ,Secrecy ,Electrical and Electronic Engineering ,business ,Information Systems ,Block (data storage) ,Computer network - Abstract
This article investigates legitimate eavesdropping and secure communication in a multicarrier interference network, where a suspicious link coexists with an unsuspicious link, in the presence of a full-duplex monitor. It is assumed that the unsuspicious users (UUs) are under illegal eavesdropping threat from the suspicious users (SUs), and the monitor can send jamming signals to interfere with the SUs. The UUs are required to cooperate with the monitor for reducing the secrecy outage probability of the UUs to be lower than that without the monitor’s jamming. Under this secrecy outage constraint along with the transmit power constraints, the problem for maximizing the successful eavesdropping probability of the monitor by jointly allocating the transmit powers of the monitor and the UUs is investigated. The problem is solved with the Lagrange duality method by proving the time-sharing property holds, where two algorithms are proposed for obtaining the dual function based on the block coordinate descent method and the successive convex approximation method. Simulation results verify that the proposed algorithms are superior to the noncooperative strategy and the passive eavesdropping strategy, and achieve high successful eavesdropping probability and low secrecy outage probability simultaneously.
- Published
- 2022
3. Travel vlogging practice and its impacts on tourist experiences
- Author
-
Jihong He, Tingzhen Chen, and Ding Xu
- Subjects
Materiality (auditing) ,business.industry ,media_common.quotation_subject ,Geography, Planning and Development ,Self-concept ,Public relations ,Popularity ,Documentation ,Tourism, Leisure and Hospitality Management ,Quality (business) ,Sociology ,business ,Tourism ,media_common - Abstract
Travel vlogging is gaining popularity and studying the practice of travel vlogging can provide insights into tourist behaviour, communication, and management. The notion of practice was adopted as the theoretical base and the analytical framework. A qualitative approach was employed, including interviews with 12 strategically sampled vlogger tourists and analysis of their vlog productions. The findings suggested that travel vlogging is a practice bundle constructed by four sequential practices; designing, filming, editing, and posting. Through a collaborative relationship, the four practices achieve the shared meanings of self-concept expressions, a sense of documentation and ritual, and pleasures in vlogging. Moreover, travel vlogging affects tourist experiences; it creates a self-other divide, mediates the experiences of the 'self', and moderates the experiences of the 'others'. Such impacts vary across the dimensions of travel stages, materiality, and engagement. Theoretically, the study offers fresh insights into the practice of vlogging and the creation of travel vlog content; pragmatically, understandings and implications for quality experiences of vlogger tourists are addressed.
- Published
- 2021
4. The Influence of Macrophage-Activating Lipopeptide-2 in Regard to Liver-Specific Changes Within a Murine Two-Hit Model
- Author
-
Peng Luo, Frank Hildebrand, Weikang Wang, Johannes Greven, Yulong Shi, Klemens Horst, Thomas Tschernig, and Ding Xu
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Immunology ,Lipopeptide ,medicine.disease ,Hepatic immune response ,Rheumatology ,Andrology ,Sepsis ,chemistry.chemical_compound ,Cytokine ,Immune system ,chemistry ,Cell culture ,Internal medicine ,Immunology and Allergy ,Medicine ,business ,Infiltration (medical) - Abstract
Trauma hemorrhage (TH) and subsequent sepsis are well known to frequently result in severe organ damage. Although macrophage-activating lipopeptide-2 (MALP-2) has been described to exert beneficial effects on organ damage, and further clinical course after both isolated trauma and sepsis, little is known about the impact of MALP-2 in a clinically realistic two-hit scenario of TH and subsequent sepsis. As the liver represents a key organ for the posttraumatic immune response and development of complications, the effects of MALP-2 on the posttraumatic hepatic immunologic response and tissue damage were investigated in a murine “two-hit” model. In C57BL/6 mice, blood pressure-controlled (35 ± 5 mm Hg) TH was induced. Cecal ligation and puncture (CLP) was performed 48 h after TH. Mice were divided into two control groups (control 1, TH and laparotomy without CLP; control 2, TH and CLP) and three experimental groups (TH + CLP) treated with MALP-2 at different timepoints (ETH, end of TH; ECLP, end of CLP; 6CLP, 6 h after CLP). The observation time lasted for 168 h after induction of TH. Kupffer cells (KC) were isolated and cultured, and MPO activity was analyzed. Cell culture supernatants were taken for cytokine analysis (TNF-α, IL-6, MCP-1, GM-CSF, IL-10). Histological analysis was performed using the Hepatic Injury Severity Scoring (HISS). Statistical evaluation was carried out using SPSS (version 24.0.0; IBM, Armonk, NY, USA). MPO activity of control 1 group was lowest compared with all the other groups (p
- Published
- 2021
5. Sum-Rate Maximization of Wireless Powered Primary Users for Cooperative CRNs: NOMA or TDMA at Cognitive Users?
- Author
-
Hongbo Zhu and Ding Xu
- Subjects
Cognitive radio ,Computer science ,business.industry ,Time division multiple access ,Wireless ,Radio frequency ,Maximization ,Electrical and Electronic Engineering ,business ,Energy harvesting ,Wireless sensor network ,Energy (signal processing) ,Computer network - Abstract
Recently, wireless powered cooperative cognitive radio networks (CRNs), which combine the technologies of radio frequency (RF) energy harvesting and CR, have drawn great attention. In such networks, energy cooperation between the cognitive users (CUs) and the wireless powered primary users (PUs) can be performed, where the CUs can charge the PUs wirelessly in exchange for the spectrum access. Specifically, energy cooperation and information transmission is executed in two phases, where the CUs transmit their data signals and the PUs harvest energy from these signals in the first phase, and the PUs transmit their data using the harvested energy in the second phase. In particular, we consider two multiple access schemes for the CUs, namely non-orthogonal multiple access (NOMA) and time-division multiple access (TDMA). For both NOMA and TDMA, the PU sum-rate maximization problems under the minimum CU sum-rate constraint are first simplified by exploring particular problem structure, then are transformed to convex problems, and finally are solved optimally. The PU sum-rates of the two schemes are compared theoretically as well as numerically. It is revealed that the circuit power consumption at the CUs, the required minimum CU sum-rate, and the PU energy harvesting sensitivity and saturation thresholds play key roles in the PU performance comparison of the two schemes.
- Published
- 2021
6. Secrecy Outage Performance Analysis of Cooperative NOMA Networks With SWIPT
- Author
-
Ding Xu, Ruoxuan Lei, and Ishtiaq Ahmad
- Subjects
business.industry ,Computer science ,Data_CODINGANDINFORMATIONTHEORY ,medicine.disease ,law.invention ,Noma ,Base station ,Control and Systems Engineering ,Relay ,law ,Secrecy ,medicine ,Benchmark (computing) ,Maximum power transfer theorem ,Wireless ,Electrical and Electronic Engineering ,business ,Decoding methods ,Computer network - Abstract
In this letter, we investigate the secrecy outage performance of a cooperative non-orthogonal multiple access (NOMA) network, where a base station (BS) communicates with multiple cell-centre users and a cell-edge user in the presence of an eavesdropper. It is assumed that there is no direct link between the BS and the cell-edge user, and thus one of the cell-centre users is selected to act as a relay for the cell-edge user. Particularly, the selected cell-centre user adopts the simultaneous wireless information and power transfer (SWIPT) for decoding information and harvesting energy for forwarding. The closed-form approximate expression for the system secrecy outage probability is derived under the max-min user selection (MMUS) strategy. The theoretical results are verified by simulations, and it is shown that the MMUS strategy outperforms various benchmark strategies.
- Published
- 2021
7. Spectrum Sharing Incentive for Legitimate Wireless Information Surveillance
- Author
-
Hongbo Zhu and Ding Xu
- Subjects
Computer Networks and Communications ,Computer science ,business.industry ,Transmitter ,Physical layer ,Aerospace Engineering ,Eavesdropping ,Transmitter power output ,Transmission (telecommunications) ,Single antenna interference cancellation ,Channel state information ,Automotive Engineering ,Wireless ,Electrical and Electronic Engineering ,business ,Computer Science::Cryptography and Security ,Computer Science::Information Theory ,Computer network - Abstract
In this paper, spectrum sharing incentive for legitimate wireless information surveillance at the physical layer is investigated. The concept behind this is that authorized government agencies want to eavesdrop the communication between a suspicious source-destination pair, and stimulate the help of another source-destination pair (referred to as secondary users) looking for transmission opportunities. We thus propose to let the secondary receiver act as a monitor to eavesdrop the suspicious communication and let the secondary transmitter act as a friendly jammer to improve the eavesdropping performance, such that they are granted to share the spectrum of the suspicious users, as a reward. To guarantee the eavesdropping performance, the successful eavesdropping probability is required to be larger than that with passive eavesdropping. The problems of jointly optimizing the transmit power of the secondary transmitter and the successive interference cancellation (SIC) decoding order at the secondary receiver to maximize the average secondary transmission rate and minimize the secondary transmission outage probability are investigated. Two scenarios are considered for the availability of the channel state information (CSI). The first scenario assumes perfect CSI, and the optimal strategies for the transmit power control and the SIC decoding ordering are derived. The second scenario assumes partial CSI, where the instantaneous CSI of the secondary transmission link and the statistical CSI of the links related to the suspicious communication are available, and the optimal strategies for maximizing an approximate average secondary transmission rate and minimizing an approximate secondary transmission outage probability are proposed. Extensive simulation results validate the effectiveness of the proposed strategies.
- Published
- 2021
8. Early urinary continence recovery following retzius-sparing robotic-assistant radical prostatectomy with suprapubic catheter: a short-term follow-up outcome
- Author
-
Ye Lei, Patrick Zanker, J. Mundhenk, Jun Qi, Zhongqing Yang, Ding Xu, and Christian Schwentner
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Time Factors ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Urination ,Urinary incontinence ,03 medical and health sciences ,Prostate cancer ,Catheters, Indwelling ,0302 clinical medicine ,Robotic Surgical Procedures ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,Prostatectomy ,Urinary continence ,business.industry ,Prostatic Neoplasms ,Recovery of Function ,Middle Aged ,medicine.disease ,Surgery ,Catheter ,Treatment Outcome ,030220 oncology & carcinogenesis ,Laparoscopic Prostatectomy ,International Prostate Symptom Score ,medicine.symptom ,Urinary Catheterization ,business ,Follow-Up Studies - Abstract
To evaluate the recovery of early urinary continence in patients with prostate cancer using a suprapubic catheter during Retzius-sparing robotic-assistant laparoscopic prostatectomy. From January 2018 to January 2019, 223 patients diagnosed with prostate cancer who underwent Retzius-sparing robotic-assistant laparoscopic prostatectomy in Diakonie Klinikum Stuttgart were involved in our study. From January 2018 to June 2018, patients (112 cases) only had an indwelling urinary catheter during Retzius-sparing robotic-assistant laparoscopic prostatectomy, while from July 2018 to January 2019, patients (111 cases) were offered an extra suprapubic catheter during operation. The recovery of early urinary continence of patients was mainly investigated one month later. The overall early urinary continence rate was 81.61%. Patients with suprapubic catheter had better urinary control results, compared to patients with only indwelling urinary catheter (87.39% vs 75.89%, p = 0.027). In addition, International Prostate Symptom Score and irritative subscore in patients with good urinary control were significantly lower than that in patients with urinary incontinence. Suprapubic catheter insertion (OR 0.395; 95% CI 0.190–0.821) and advanced pathological tumor stage (T3a–T4) (OR 2.061; 95% CI 1.008–4.217) were two independent influencing factors for early urinary continence recovery in patients who underwent Retzius-sparing robotic-assistant laparoscopic prostatectomy through multivariate logistic regression analysis. Suprapubic catheter insertion may be helpful for early urinary continence recovery in patients with Retzius-sparing Robotic-assistant laparoscopic prostatectomy. Advanced pathological tumor stage (T3a–T4) before Retzius-sparing robotic-assistant laparoscopic prostatectomy might be associated with poor urinary control.
- Published
- 2021
9. On the Outage Performance of JT-CoMP-CNOMA Networks With SWIPT
- Author
-
Ruoxuan Lei and Ding Xu
- Subjects
Computer science ,business.industry ,020206 networking & telecommunications ,02 engineering and technology ,Computer Science Applications ,Scheduling (computing) ,Base station ,Transmission (telecommunications) ,Modeling and Simulation ,0202 electrical engineering, electronic engineering, information engineering ,Maximum power transfer theorem ,Wireless ,Electrical and Electronic Engineering ,business ,Energy (signal processing) ,Decoding methods ,Computer network - Abstract
In this letter, we investigate the outage performance of a joint transmission coordinated multipoint cooperative non-orthogonal multiple access (JT-CoMP-CNOMA) network. It is assumed that there is no direct links between the base stations and the cell-edge user, and thus the cell-centre users act as relays for the cell-edge user. The cell-centre users are assumed to be energy-constrained and adopt the simultaneous wireless information and power transfer (SWIPT) for decoding information and harvesting energy for forwarding. The closed-form approximate expressions for the outage probabilities of the users are derived. The theoretical results are verified by conducting Monte-Carlo simulations. It is shown that significant performance gain for the cell-edge user is achieved by JT-CoMP-CNOMA compared to the conventional CNOMA and the CoMP-CNOMA with opportunistic scheduling.
- Published
- 2021
10. The Influence of Macrophage-Activating Lipopeptide 2 (MALP-2) on Local and Systemic Inflammatory Response in a Murine Two-Hit Model of Hemorrhagic Shock and Subsequent Sepsis
- Author
-
Johannes Greven, Thomas Tschernig, Frank Hildebrand, Peng Luo, Klemens Horst, Yulong Shi, Weikang Wang, and Ding Xu
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Chemokine ,Inflammatory response ,Immunology ,Anti-Inflammatory Agents ,Shock, Hemorrhagic ,Gastroenterology ,Proinflammatory cytokine ,Sepsis ,Lipopeptides ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Immune system ,Internal medicine ,medicine ,Animals ,Immunology and Allergy ,Lung ,Inflammation ,biology ,business.industry ,Murine two-hit model ,Lipopeptide ,medicine.disease ,Rheumatology ,Mice, Inbred C57BL ,Survival Rate ,MALP-2 ,Treatment Outcome ,030104 developmental biology ,chemistry ,Hemorrhagic shock ,030220 oncology & carcinogenesis ,biology.protein ,Cytokines ,Wounds and Injuries ,Original Article ,Chemokines ,business ,Infiltration (medical) ,Biomarkers - Abstract
Pulmonary complications after severe trauma and sepsis remain to be the main cause for adverse outcome. MALP-2 has been described to exert beneficial effects on organ damage and the further course after isolated trauma and sepsis. However, the impact of MALP-2 on a clinically realistic two-hit scenario of trauma and subsequent sepsis remains unknown. We, therefore, investigated if the systemic inflammatory response and pulmonary immune response and damage are beneficially modulated by MALP-2 in a murine two-hit model. Blood pressure-controlled trauma-hemorrhage (TH) and cecal ligation and puncture (CLP) were induced in C57/BL6 mice. Mice were divided into 2 control groups (control 1: TH without CLP; control 2: TH and CLP) and 3 experimental groups treated with MALP-2 at different time points (ETH, end of TH; ECLP, end of CLP; and 6CLP 6 h after CLP). Survival rates were assessed over the observation period of 168 h after the induction of TH. Concentrations of plasma inflammatory cytokines and chemokines (TNF-α, IL-6, MIP-1α, IFN-γ, and IL-10) were assessed, and bacterial clearance of the lungs was determined. Furthermore, pulmonary MPO activity assay to evaluate the infiltration of polymorphonuclear neutrophils (PMN) and histological evaluation were performed. Survival rates were evaluated. Compared with control group 1, the level of TNF-α in the ECLP group showed a significant increase (ECLP, 2.27 pg./ml ± 1.39 vs. control 1: 0.16 pg./ml ± 0.11, p = 0.021). In contrast, levels of IFN-γ were significantly reduced in groups ETH and 6CLP compared with control group 1 (control 1: 8.92 pg./ml ± 4.38 vs. ETH: 1.77 pg./ml ± 4.34, p = 0.026 resp. vs. 6CLP: 1.83 pg./ml ± 4.49, p = 0.014). While systemic concentrations of inflammatory mediators were not affected by MALP-2 treatment, the lung tissue presented with significant alterations. Reduced MPO activity was lowest in group ECLP (ECLP 11,196.77 ± 547.81 vs. ETH 12,773.94 ± 1011.76; p = 0.023 resp. vs. 6CLP 13,155.19 ± 423.99, p = 0.016) in experimental groups. Also, histological damage after MALP-2 application was lowest in ECLP animals (ECLP 0.50 ± 0.08 vs. ETH 0.71 ± 0.05, p = 0.034 resp. vs. 6CLP 0.64 ± 0.08, p = 0.021). Furthermore, MALP-2 treatment was associated with a trend towards improved survival in the ECLP group (ECLP 83.3% vs. ETH 66.7 and 6CLP 58.3%, p > 0.05). Based on our results, MALP-2 might have beneficial effects on the clinical course after hemorrhage and sepsis by reducing pulmonary damage and PMN infiltration. This might also affect survival. According to our data, MALP-2 should be given at the earliest possible time point after the onset of sepsis. However, the optimal dosage and confirmation of our results in larger cohorts need to be the focus of further research.
- Published
- 2021
11. Pain and Spirituality Outcomes Among Women With Advanced Breast Cancer Participating in a Foot Reflexology Trial
- Author
-
Gwen Wyatt, Ding Xu, Rebecca H. Lehto, Jason S. Moser, Megan Miller, and Horng-Shiuann Wu
- Subjects
medicine.medical_specialty ,Reflexology ,business.industry ,Pain ,Breast Neoplasms ,medicine.disease ,Musculoskeletal Manipulations ,Article ,Spiritual Therapies ,law.invention ,Odds ,Breast cancer ,Randomized controlled trial ,law ,Intervention (counseling) ,Spirituality ,Physical therapy ,Humans ,Medicine ,Hormonal therapy ,Female ,Spiritual care ,business - Abstract
OBJECTIVES: To examine pain and spirituality, demographic/clinical factors associated with pain and spirituality, the contribution of spirituality to experiences pain over time, and how pain and spirituality relate to engagement with a caregiver-delivered intervention. SAMPLE & SETTING: Women with advanced breast cancer (n=256) enrolled in a home-based randomized controlled trial of foot reflexology. METHODS & VARIABLES: Secondary analyses were conducted with baseline and post-intervention data (including reflexology and control groups). Stepwise model building, linear mixed effects modeling and negative binomial regression were employed. Measures: Patient Reported Outcomes Measurement Information System-pain intensity; Long-Term Quality of Life- Spiritual/Philosophical subscale; demographic/clinical variables. RESULTS: Mean pain was 3.6/10 and spirituality was 3.2/4.0 at baseline. Participants who were younger (p
- Published
- 2021
12. Extra-domain B of fibronectin as an alternative target for drug delivery and a cancer diagnostic and prognostic biomarker for malignant glioma
- Author
-
Wonki Yoon, Sangyong Jon, Yoo Jin Na, Phei Er Saw, Yeo Song Lee, Taek-Hyun Kwon, Jong-Hyun Kim, Hyungsin Kim, Kyuha Chong, Chulhee Choi, Xiao-Ding Xu, Youn-Kwan Park, Hong Joo Moon, Jungsul Lee, Chungyeul Kim, Bo Ram Kang, Joo Han Kim, and Shin Hyuk Kang
- Subjects
Male ,Big Data ,medicine.medical_treatment ,Mice, Nude ,Medicine (miscellaneous) ,Antineoplastic Agents ,Apoptosis ,Docetaxel ,EDB-Fibronectin ,Mice ,03 medical and health sciences ,Drug Delivery Systems ,0302 clinical medicine ,In vivo ,Glioma ,Biomarkers, Tumor ,Tumor Cells, Cultured ,Animals ,Humans ,Medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Micelles ,Cell Proliferation ,030304 developmental biology ,Mice, Inbred BALB C ,0303 health sciences ,Tissue microarray ,Brain Neoplasms ,business.industry ,Cancer ,Middle Aged ,Prognosis ,medicine.disease ,Xenograft Model Antitumor Assays ,Fibronectins ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,Radioimmunotherapy ,Drug delivery ,Cancer cell ,Cancer research ,Nanoparticles ,Biomarker (medicine) ,Female ,business ,Biomarkers ,Research Paper - Abstract
Extra-domain B of fibronectin (EDB-FN) is an alternatively spliced form of fibronectin with high expression in the extracellular matrix of neovascularized tissues and malignant cancer cells. In this study, we evaluated the practicality of using EDB-FN as a biomarker and therapeutic target for malignant gliomas (MGs), representative intractable diseases involving brain tumors. Methods: The microarray- and sequence-based patient transcriptomic database 'Oncopression' and tissue microarray of MG patient tissue samples were analyzed. EDB-FN data were extracted and evaluated from 23,344 patient samples of 17 types of cancer to assess its effectiveness and selectivity as a molecular target. To strengthen the results of the patient data analysis, the utility of EDB-FN as a molecular marker and target for MG was verified using active EDB-FN-targeting ultrasmall lipidic micellar nanoparticles (~12 nm), which had a high drug-loading capacity and were efficiently internalized by MG cells in vitro and in vivo. Results: Brain tumors had a 1.42-fold cancer-to-normal ratio (p < 0.0001), the second highest among 17 cancers after head and neck cancer. Patient tissue microarray analysis showed that the EDB-FN high-expression group had a 5.5-fold higher risk of progression than the EDB-FN low-expression group (p < 0.03). By labeling docetaxel-containing ultrasmall micelles with a bipodal aptide targeting EDB-FN (termed APTEDB-DSPE-DTX), we generated micelles that could specifically bind to MG cells, leading to superior antitumor efficacy of EDB-FN-targeting nanoparticles compared to nontargeting controls. Conclusions: Taken together, these results show that EDB-FN can be an effective drug delivery target and biomarker for MG.
- Published
- 2021
13. Legitimate Surveillance With Battery-Aided Wireless Powered Full-Duplex Monitor
- Author
-
Ding Xu
- Subjects
021103 operations research ,Computer Networks and Communications ,Computer science ,business.industry ,Real-time computing ,0211 other engineering and technologies ,Jamming ,02 engineering and technology ,Transmitter power output ,Computer Science Applications ,Control and Systems Engineering ,Benchmark (computing) ,Wireless ,Electrical and Electronic Engineering ,Online algorithm ,business ,Energy harvesting ,Energy (signal processing) ,Decoding methods ,Information Systems - Abstract
This letter investigates legitimate surveillance of suspicious communication with a battery-aided full-duplex wireless powered monitor. The suspicious communication consists of multiple time slots, and the aim of the monitor is to maximize the number of slots that can be successfully wiretapped. To enhance the surveillance performance, the monitor can send jamming signals using the energy stored in the battery. It is assumed that the power splitting is used by the monitor for simultaneous energy harvesting and information decoding, and the harvested energy is accumulated in the battery for usage in future slots. The power splitting ratio and the jamming transmit power are optimized with the energy causality constraint under both the offline and online settings of the channel power gains. It is shown that all the proposed algorithms outperform the benchmark algorithm, and the proposed low-complexity suboptimal offline algorithm and the online algorithm are close to optimal.
- Published
- 2020
14. Proactive Eavesdropping of Suspicious Non-Orthogonal Multiple Access Networks
- Author
-
Ding Xu
- Subjects
Access network ,Computer Networks and Communications ,business.industry ,Computer science ,Heuristic (computer science) ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Aerospace Engineering ,020302 automobile design & engineering ,Eavesdropping ,Jamming ,02 engineering and technology ,0203 mechanical engineering ,Single antenna interference cancellation ,Automotive Engineering ,Telecommunications link ,Benchmark (computing) ,Electrical and Electronic Engineering ,business ,Decoding methods ,Computer network - Abstract
In this correspondence, legitimate surveillance of a downlink suspicious non-orthogonal multiple access (NOMA) network with multiple groups of suspicious users (SUs), in the presence of a full-duplex monitor equipped with a successive interference cancellation (SIC) decoder, is investigated. Proactive eavesdropping is adopted, i.e., the monitor simultaneously eavesdrops the suspicious communications, and sends jamming signals. The problem of maximizing the number of successfully eavesdropped SUs by jointly optimizing the jamming power allocation and the decoding order at the monitor is investigated considering both imperfect full-duplex self-interference cancellation, and imperfect SIC. By exploring the particular problem structure, a heuristic iterative algorithm is proposed, where the optimal decoding at the monitor is proved to be equal to that at the SUs. Extensive simulations confirm that the proposed algorithm achieves performance very close to the optimal one but with significantly lower complexity, and outperforms various benchmark algorithms.
- Published
- 2020
15. Visitors’ spatio-temporal behavior at a zoo in China
- Author
-
Ding Xu, Li Cong, and Geoffrey Wall
- Subjects
business.industry ,Wildlife tourism ,05 social sciences ,Geography, Planning and Development ,Environmental resource management ,Destination marketing ,Geography ,Beijing ,Tourism, Leisure and Hospitality Management ,Gps data ,0502 economics and business ,Global Positioning System ,Survey data collection ,050211 marketing ,business ,China ,050212 sport, leisure & tourism ,Tourism - Abstract
Information on tourists’ spatio-temporal behavior is useful for destination marketing and management. GPS data collection, GIS and statistical analyses of survey data from a zoo in Beijing are repo...
- Published
- 2020
16. Identification of a novel immune prognostic model in gastric cancer
- Author
-
Xiaoqin He, Yangtao Xu, Yirong Li, Xiaoyu Zhang, Li Fan, and Xiao-Ding Xu
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,animal diseases ,Gene Expression ,chemical and pharmacologic phenomena ,Eosinophil-Derived Neurotoxin ,Transcriptome ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Databases, Genetic ,Immune Tolerance ,Tumor Microenvironment ,medicine ,Humans ,Dwarfism, Pituitary ,IRGs ,Survival analysis ,Framingham Risk Score ,Proportional hazards model ,business.industry ,Immunity ,Models, Immunological ,General Medicine ,biochemical phenomena, metabolism, and nutrition ,Immune Checkpoint Proteins ,Prognosis ,Survival Analysis ,030104 developmental biology ,CXCL3 ,NADPH Oxidase 4 ,030220 oncology & carcinogenesis ,Disease Progression ,Neoplastic Stem Cells ,Prognostic model ,Cytokines ,Regression Analysis ,bacteria ,business ,Chemokines, CXC - Abstract
The tumor immune microenvironment (TIME) is now considered as an important factor during gastric cancer (GC) development. This study identified a novel immune-related risk model for predicting prognosis and assessing the immune status of GC patients. Transcriptomic data were obtained from the TCGA database. The differential expressed immune-related genes (IRGs) were identified through the ImmPort portal. Enrichment analysis was performed to explore the potential molecular mechanism of these IRGs. By the Cox regression analysis, we constructed the immune prognostic model. Then, the association between the model and the immune microenvironment was estimated. The model was validated in the GSE84433 dataset. Totally, we identified 222 differentially expressed IRGs. These IRGs were closely correlated with immune response and immune signaling pathways. Through the Cox regression analysis, we developed the immune prognostic model based on the expression of seven IRGs (CXCL3, NOX4, PROC, FAM19A4, RNASE2, IGHD2-15, CGB5). Patients were stratified into two groups according to immune-related risk scores. Survival analysis indicated that the prognosis of high-risk patients was poorer than low-risk patients. Moreover, the immune-related risk score was an independent prognostic biomarker. More importantly, we found that the infiltration level of immunosuppressive cells and the expression of inhibitory immune checkpoints were higher in high-risk patients. The immune microenvironment tended to be a suppressive status in patients with high-risk scores. This study demonstrated that our model had predictive value for prognosis and the TIME in GC. It might be a robust tool to improve personalized patient management.
- Published
- 2020
17. China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations
- Author
-
Jing Wu, Li Guo, Yong-Jun Wang, Qiang Dong, Xin Yang, Hao Wang, David Wang, Jing Jing, Hao Li, Shuo Wang, Chen Wang, Xia Meng, Hai-Bo Wang, Lin-Hong Wang, Yong Jiang, Li-Ping Liu, Yi-long Wang, An-ding Xu, Yi Yang, Zhong-Rong Miao, Ji-Zong Zhao, Tong Zhang, Bo Hu, Ning Wang, Peng Xie, Gang Zhao, Ying Shi, Hong-Qiu Gu, Zi-Xiao Li, Yi Zhai, Xing-Quan Zhao, Chun-Juan Wang, Bei-Sha Tang, Chang Yin, Chuan-Qiang Pu, Dong-Shen Fan, Dong Zhou, Jin-Sheng Zeng, Lan-Xia Gan, Li-Min Wang, Li-Ying Cui, Mei-Jia Zhu, Ming Lou, Tao Feng, Wen-Hua Zhao, Xu-Dong Ma, Xun-Ming Ji, Yi-Ming Deng, Yu-Ming Xu, Yu-Ping Wang, and Xiao-Yuan Niu
- Subjects
Pediatrics ,medicine.medical_specialty ,education.field_of_study ,business.industry ,Mortality rate ,Population ,Atrial fibrillation ,030204 cardiovascular system & hematology ,Non-communicable disease ,medicine.disease ,Comorbidity ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,Years of potential life lost ,Diabetes mellitus ,Epidemiology ,medicine ,cardiovascular diseases ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,education ,lcsh:Neurology. Diseases of the nervous system ,030217 neurology & neurosurgery - Abstract
China faces the greatest challenge from stroke in the world. The death rate for cerebrovascular diseases in China was 149.49 per 100 000, accounting for 1.57 million deaths in 2018. It ranked third among the leading causes of death behind malignant tumours and heart disease. The age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100 000 population and 246.8 per 100 000 person-years, respectively. According to the Global Burden of Disease Study 2017, the years of life lost (YLLs) per 100 000 population for stroke increased by 14.6%; YLLs due to stroke rose from third highest among all causes in 1990 to the highest in 2017. The absolute numbers and rates per 100 000 population for all-age disability-adjusted life years (DALYs) for stroke increased substantially between 1990 and 2017, and stroke was the leading cause of all-age DALYs in 2017. The main contributors to cerebrovascular diseases include behavioural risk factors (smoking and alcohol use) and pre-existing conditions (hypertension, diabetes mellitus, dyslipidaemia and atrial fibrillation (AF)). The most prevalent risk factors among stroke survivors were hypertension (63.0%-84.2%) and smoking (31.7%-47.6%). The least prevalent was AF (2.7%-7.4%). The prevalences for major risk factors for stroke are high and most have increased over time. Based on the latest national epidemiological data, 26.6% of adults aged ≥15 years (307.6 million adults) smoked tobacco products. For those aged ≥18 years, age-adjusted prevalence of hypertension was 25.2%; adjusted prevalence of hypercholesterolaemia was 5.8%; and the standardised prevalence of diabetes was 10.9%. For those aged ≥40 years, the standardised prevalence of AF was 2.31%. Data from the Hospital Quality Monitoring System showed that 3 010 204 inpatients with stroke were admitted to 1853 tertiary care hospitals during 2018. Of those, 2 466 785 (81.9%) were ischaemic strokes (ISs); 447 609 (14.9%) were intracerebral haemorrhages (ICHs); and 95 810 (3.2%) were subarachnoid haemorrhages (SAHs). The average age of patients admitted was 66 years old, and nearly 60% were male. A total of 1555 (0.1%), 2774 (0.6%) and 1347 (1.4%) paediatric strokes (age
- Published
- 2020
18. Cognitive and emotional predictors of real versus sham repetitive transcranial magnetic stimulation treatment response in methamphetamine use disorder
- Author
-
Haifeng Jiang, Xiaotong Li, Ke Xiao, Chunmei Duan, Weidong Song, Yiran Meng, Ding Xu, Min Zhao, Hang Su, Na Zhong, Jiang Du, Congbin Zhang, and Tianzhen Chen
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Emotions ,Prefrontal Cortex ,Craving ,Audiology ,Impulsivity ,behavioral disciplines and activities ,Spatial memory ,Methamphetamine ,03 medical and health sciences ,Cognition ,0302 clinical medicine ,mental disorders ,medicine ,Humans ,Prospective Studies ,Biological Psychiatry ,business.industry ,medicine.disease ,Transcranial Magnetic Stimulation ,030227 psychiatry ,Transcranial magnetic stimulation ,Psychiatry and Mental health ,Treatment Outcome ,Anxiety ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Anxiety disorder ,medicine.drug - Abstract
Background and aims Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) can effectively reduce cravings in methamphetamine use disorder (MUD). However, a considerable group still fails to respond. Cognitive and emotional disturbance, as well as impulsive features, are widespread in patients with MUD and might mediate the treatment response of rTMS. The purpose of this study is to figure out whether these variables can help predicting patients' responses to rTMS treatment. Methods Ninety-seven patients with severe MUD and thirty-one gender- and age-matched healthy subjects were included. Patients were randomized to receive 20 sessions of real or sham rTMS. Intermittent theta burst protocols (iTBS) or sham iTBS were applied every weekday over the DLPFC for 20 daily sessions. Both groups received regular treatment. Craving induced by drug-related cue was measured before and after stimulation. Cognition was evaluated by using the CogState Battery. Baseline characteristics were collected through the Addiction Severity Index, Patient Health Questionnaire-9, General Anxiety Disorder Scale-7, and Barrett Impulsivity Scale-11. Results Results showed that patients with MUD have worse spatial working memory, problem-solving ability, as well as depression and anxiety symptoms compared with healthy controls. Cognition and emotion differed between responders (craving decrease ≥60%) and non-responders in real rTMS group but not in the sham group. Better cognitive and emotional functions means that patients have higher possibility for better response to real rTMS treatment. Conclusions This study suggests that cognitive, emotional and impulsive features could be used to predict the prospective treatment responses of rTMS in patients with MUD.
- Published
- 2020
19. Review of pathological index detection and new rehabilitation technique of drug addicts
- Author
-
Chao Gu, Banghua Yang, Ding Xu, Xuelin Gu, and Chengcheng Fan
- Subjects
Drug ,medicine.medical_specialty ,Index (economics) ,Rehabilitation ,Polymers and Plastics ,business.industry ,media_common.quotation_subject ,medicine.medical_treatment ,05 social sciences ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Detoxification ,Drug addict ,medicine ,0501 psychology and cognitive sciences ,business ,Intensive care medicine ,Pathological ,030217 neurology & neurosurgery ,General Environmental Science ,media_common - Abstract
There are two major research issues with regard to detoxification; one is pathological testing of drug users and the other is rehabilitation methods and techniques. Over the years, domestic and foreign researchers have done a lot of work on pathological changes in the brain and rehabilitation techniques for drug users. This article discusses the research status of these two aspects. At present, the evaluation of brain function in drug addicts is still dominated by a single electroencephalography (EEG), near-infrared spectroscopy (NIRS), or magnetic resonance imaging scan. The multimodal physiological data acquisition method based on EEG–NIRS technique is relatively advantageous for actual physiological data acquisition. The traditional drug rehabilitation method is based on medication and psychological counseling. In recent years, psychological correction (e.g., emotional ventilation, intelligent physical and mental decompression, virtual reality technique and drug addiction suppression system, sports training, and rehabilitation) and physical therapy (transcranial magnetic stimulation) have gradually spread. These rehabilitations focus on comprehensive treatment from the psychological and physical aspects. In recent years, new intervention ideas such as brain–computer interface technique have been continuously proposed. In this review, we have introduced multimodal brain function detection and rehabilitation intervention, which have theoretical and practical significance in drug rehabilitation research.
- Published
- 2020
20. Auction-Based Resource Allocation for Mobile Edge Computing Networks
- Author
-
Ding Xu and Ben Liu
- Subjects
Mobile edge computing ,Computer science ,business.industry ,Applied Mathematics ,Signal Processing ,Resource allocation ,Electrical and Electronic Engineering ,business ,Computer Graphics and Computer-Aided Design ,Computer network - Published
- 2020
21. Intermittent theta burst transcranial magnetic stimulation for methamphetamine addiction: A randomized clinical trial
- Author
-
Min Zhao, Haifeng Jiang, Weidong Song, Ke Xiao, Hang Su, Na Zhong, Jiang Du, Tianzhen Chen, and Ding Xu
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,media_common.quotation_subject ,Amphetamine-Related Disorders ,Craving ,behavioral disciplines and activities ,Methamphetamine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Double-Blind Method ,Randomized controlled trial ,law ,Intervention (counseling) ,mental disorders ,medicine ,Humans ,Pharmacology (medical) ,Theta Rhythm ,Biological Psychiatry ,media_common ,Pharmacology ,Rehabilitation ,business.industry ,Addiction ,Cognition ,Transcranial Magnetic Stimulation ,030227 psychiatry ,Behavior, Addictive ,Transcranial magnetic stimulation ,Psychiatry and Mental health ,nervous system ,Neurology ,Female ,Neurology (clinical) ,medicine.symptom ,business ,psychological phenomena and processes ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Methamphetamine is the most commonly used illicit drug in China. We previously demonstrated that 10 Hz rTMS over the DLPFC reduces craving in methamphetamine users. Here, we applied intermittent theta burst stimulation (iTBS), a new form of rTMS, in a large sample at four clinical centers. 126 participants (age 31.64 ± 6.33; 106 men) with severe methamphetamine use disorder according to DSM-5 were randomized to receive either iTBS or sham over the DLPFC for four weeks (20 daily sessions, 900 pulses per day). Cue-induced craving and cognitive function were assessed before and after rTMS intervention. Relapse was followed up by urine test after discharge from the rehabilitation center. iTBS significantly reduced craving and improved cognition and sleep quality. This study suggests that rTMS may be a useful and safe treatment option for methamphetamine use disorder, warranting future large scale trials.
- Published
- 2020
22. Optimizing Wireless Sensor Networks Based on Collaborative Beamforming
- Author
-
Lei Shi, Zhehao Li, Zengwei Lv, Juan Xu, and Ding Xu
- Subjects
Beamforming ,Wireless network ,Computer science ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,020206 networking & telecommunications ,Throughput ,Data_CODINGANDINFORMATIONTHEORY ,02 engineering and technology ,law.invention ,Relay ,law ,Computer Science::Networking and Internet Architecture ,0202 electrical engineering, electronic engineering, information engineering ,General Earth and Planetary Sciences ,020201 artificial intelligence & image processing ,business ,Wireless sensor network ,Computer Science::Information Theory ,General Environmental Science ,Data transmission ,Computer network - Abstract
With the expansion of the scale of the Internet of Things, the transmission distance and speed of wireless networks need to be improved. Due to the limitation of power and energy of sensor nodes, data transmission is basically carried out by multi-hop relay. Collaborative beamforming is a technology that uses multiple sensor nodes to form a virtual antenna array to transmit high-gain and directional beams, which greatly enhances the transmission range. Compared with the muilt-hop network, collaborative beamforming can reduce the numbers of hop or even transmit data to the target node at one time, thus reducing the time required for routing and forwarding. This means that collaborative beamforming can transmit data more quickly and improve data throughput. In this paper, a brief introduction of cooperative beamforming is given. Then we propose an algorithm based on Collaborative beamforming. Simulation results show that the Collaborative beamforming wireless sensor networks can achieve better throughput compared with multi-hop networks.
- Published
- 2020
23. Secure Transmission for SWIPT IoT Systems With Full-Duplex IoT Devices
- Author
-
Hongbo Zhu and Ding Xu
- Subjects
Computer Networks and Communications ,Computer science ,Orthogonal frequency-division multiplexing ,Orthogonal frequency-division multiple access ,Time division multiple access ,Duplex (telecommunications) ,Jamming ,Data_CODINGANDINFORMATIONTHEORY ,02 engineering and technology ,0203 mechanical engineering ,Telecommunications link ,Computer Science::Networking and Internet Architecture ,0202 electrical engineering, electronic engineering, information engineering ,Wireless ,Secure transmission ,Computer Science::Information Theory ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Physical layer ,020302 automobile design & engineering ,020206 networking & telecommunications ,Computer Science Applications ,Hardware and Architecture ,Channel state information ,Signal Processing ,business ,Information Systems ,Computer network - Abstract
This article investigates physical layer security of a downlink multiuser orthogonal frequency division multiplexing (OFDM) Internet of Things (IoT) system with an access point communicating with multiple legitimate IoT devices in the presence of multiple eavesdroppers. For coordinating multiuser communication, the orthogonal frequency division multiple access (OFDMA) and time division multiple access (TDMA) are considered. The IoT devices are assumed to support simultaneous wireless information and power transfer (SWIPT) and can use the harvested energy to jam the eavesdroppers based on full-duplex. The resource allocation problems of maximizing the sum secrecy rate for the OFDMA and TDMA systems are investigated. We first consider the scenario that perfect channel state information (CSI) is available and derive suboptimal algorithms based on alternating optimization. Then we consider the scenario that CSI is imperfect and propose heuristic algorithms. The secrecy performances of the OFDMA and TDMA systems with jamming from the SWIPT IoT devices are compared using extensive simulations. It is shown that the secrecy performance of the OFDMA system is superior over the TDMA system. It is also shown that the algorithm with imperfect CSI is inferior over the algorithm with perfect CSI, but it can outperform the benchmark algorithm with perfect CSI and without jamming.
- Published
- 2019
24. iTRAQ-based proteomics analysis of aqueous humor in patients with dry age-related macular degeneration
- Author
-
Ting-Ting Li, Sichang Qu, Fang Liu, Ding Xu, and Jing-Fa Zhang
- Subjects
genetic structures ,Proteomics ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Western blot ,Liquid chromatography–mass spectrometry ,Medicine ,KEGG ,age-related macular degeneration ,Investigation ,chemistry.chemical_classification ,medicine.diagnostic_test ,business.industry ,Macular degeneration ,medicine.disease ,differential expression of proteins ,eye diseases ,isobaric tags for relative and absolute quantification ,Ophthalmology ,chemistry ,Biochemistry ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,sense organs ,protein biomarker ,aqueous humor ,business ,Carbonic anhydrase 3 ,Glycoprotein ,Oxidative stress - Abstract
AIM: To preliminarily test proteomics in aqueous humor in patients with dry age-related macular degeneration (AMD) by using the proteomic technology. METHODS: Aqueous humor samples were collected from patients with or without dry AMD, who underwent cataract surgery. The aqueous samples were analyzed with isobaric tags for relative and absolute quantification (iTRAQ) combined with liquid chromatography tandem mass spectrometry (LC-MS/MS) technology. The differential expressed proteins were analyzed with gene ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interaction (PPI) network analysis. The data were partly validated by ELISA and Western blot. False discovery rate (FDR) was used for statistical analysis. RESULTS: A total of 244 proteins were detected, in which 38 proteins were up-regulated and 51 were down-regulated significantly in patients with dry AMD compared with that in control groups (FDR value
- Published
- 2019
25. One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial
- Author
-
Ding Xu, Qing Chang, Guoyou Qin, Jingke Zhao, Wei Zhang, Fenghua Wang, Fei Yuan, Ling Wang, Yuanzhi Yuan, Xiaofeng Ye, Qi Zhang, Mengxi Shen, Xiaodong Sun, Peiquan Zhao, and Fang Wang
- Subjects
medicine.medical_specialty ,Visual acuity ,Article Subject ,genetic structures ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Pro re nata ,Age related ,Ophthalmology ,medicine ,030212 general & internal medicine ,Potential risk ,business.industry ,Macular degeneration ,medicine.disease ,Regimen ,lcsh:RE1-994 ,Clinical Study ,030221 ophthalmology & optometry ,Ranibizumab ,Intravitreal ranibizumab ,medicine.symptom ,business ,medicine.drug - Abstract
Purpose. To compare the functional and anatomical outcomes of one dose and three loading doses followed by the pro re nata (PRN) regimen in Chinese neovascular age-related macular degeneration (nvAMD) (including polypoidal choroidal vasculopathy (PCV)) patients. Methods. In this multicenter, prospective, open-label, controlled, 12-month study (ClinicalTrials.gov: NCT02810808), patients were randomized (1 : 1) to 1 dose + PRN (PRN group) or 3 loading doses + PRN (LD group) using intravitreal ranibizumab treatment. Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were evaluated. The main outcome was the change in BCVA. The noninferiority limit was 5 letters. Results. Forty-five patients in the PRN group and 49 patients in the LD group finished 12-month follow-up. Each group included 4 PCV patients. The mean change in BCVA from baseline was 7.8 letters in the PRN group, compared with 10.9 letters in the LD group (P=0.344). There were no significant differences between two groups in the mean change of CRT (−159.3 μm vs. −120.5 μm) at month 12. The mean number of injections during the 12-month follow-up was 6.0 in the PRN group and 6.8 in the LD group. The proportion of patients who gained an improvement in visual acuity by 15 or more letters was 28.9% in the PRN group and 44.9% in the LD group (P=0.066). Conclusion. One dose + PRN showed noninferior visual gains than 3 loading doses + PRN regimen using ranibizumab in Chinese nvAMD and PCV patients. Number of injections in the PRN group was similar as that in the LD group but remained a potential risk of vision instability during one-year follow-up using OCT-guided retreatment criteria. This trial is registered with NCT02810808.
- Published
- 2019
26. Proactive eavesdropping of wireless powered suspicious interference networks
- Author
-
HongBo Zhu and Ding Xu
- Subjects
General Computer Science ,business.industry ,Computer science ,Wireless ,Eavesdropping ,business ,Interference (wave propagation) ,Computer network - Published
- 2021
27. Risk factors of postoperative shoulder pain in acromioclavicular joint dislocation treat with the hook plate: A retrospective study
- Author
-
Jianming Chen, Ding Xu, Yi Chen, and Weigang Lou
- Subjects
medicine.medical_specialty ,RD1-811 ,business.industry ,Hook plate ,Retrospective cohort study ,AC dislocation ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Acromioclavicular Joint ,Risk Factors ,Shoulder Pain ,Dislocation (syntax) ,Medicine ,Acromioclavicular joint ,Humans ,AC DISLOCATION ,Risk factor ,business ,Bone Plates ,Retrospective Studies - Published
- 2021
28. Application of bi-modal signal in the classification and recognition of drug addiction degree based on machine learning
- Author
-
Banghua Yang, Lin Feng Yan, Shouwei Gao, Wen Wang, Ding Xu, and Xuelin Gu
- Subjects
Normalization (statistics) ,drug addiction ,Process (engineering) ,Computer science ,Substance-Related Disorders ,media_common.quotation_subject ,eeg-nirs ,degree of drug addiction ,Electroencephalography ,Machine learning ,computer.software_genre ,Convolutional neural network ,bi-modal signal ,3-class accuracy ,Machine Learning ,Robustness (computer science) ,medicine ,QA1-939 ,Humans ,Sensitivity (control systems) ,media_common ,Measure (data warehouse) ,medicine.diagnostic_test ,business.industry ,Applied Mathematics ,Addiction ,General Medicine ,Computational Mathematics ,Modeling and Simulation ,Artificial intelligence ,Neural Networks, Computer ,General Agricultural and Biological Sciences ,business ,computer ,TP248.13-248.65 ,Mathematics ,Algorithms ,Biotechnology - Abstract
Most studies on drug addiction degree are made based on statistical scales, addicts' account, and subjective judgement of rehabilitation doctors. No objective, quantified evaluation has been made. This paper uses devises the synchronous bimodal signal collection and experimentation paradigm with electroencephalogram (EEG) and forehead high-density near-infrared spectroscopy (NIRS) device. The drug addicts are classified into mild, moderate and severe groups with reference to the suggestions of researchers and medical experts. Data of 45 drug addicts (mild: 15; moderate: 15; and severe: 15) is collected, and then used to design an addiction degree testing algorithm based on decision fusion. The algorithm is used to classify mild, moderate and severe addiction. This paper pioneers to use two types of Convolutional Neural Network (CNN) to abstract the EEG and NIR data of drug addicts, and introduces batch normalization to CNN, thus accelerating training process, reducing parameter sensitivity, and enhancing system robustness. The characteristics output by two CNNs are transformed into dimensions. Two new characteristics are assigned with a weight of 50% each. The data is used for decision fusion. In the networks, 27 subjects are used as training sets, 9 as validation sets, and 9 as testing sets. The 3-class accuracy remains to be 63.15%, preliminarily justifying this method as an effective approach to measure drug addiction degree. And the method is ready to use, objective, and offers results in real time.
- Published
- 2021
29. Secure communication in wireless powered communication networks with energy accumulation
- Author
-
Ding Xu
- Subjects
General Computer Science ,Secure communication ,business.industry ,Computer science ,Wireless ,business ,Telecommunications network ,Energy (signal processing) ,Computer network - Published
- 2021
30. Modulation of Methamphetamine-Related Attention Bias by Intermittent Theta-Burst Stimulation on Left Dorsolateral Prefrontal Cortex
- Author
-
Tianzhen Chen, Hang Su, Lihui Wang, Xiaotong Li, Qianying Wu, Na Zhong, Jiang Du, Yiran Meng, Chunmei Duan, Congbin Zhang, Wen Shi, Ding Xu, Weidong Song, Min Zhao, and Haifeng Jiang
- Subjects
medicine.medical_specialty ,QH301-705.5 ,medicine.medical_treatment ,030508 substance abuse ,Attentional bias ,Audiology ,behavioral disciplines and activities ,Cell and Developmental Biology ,03 medical and health sciences ,0302 clinical medicine ,event-related potential ,Event-related potential ,mental disorders ,transcranial magnetic stimulation ,Medicine ,Biology (General) ,methamphetamine ,attention bias ,Original Research ,dorsolateral prefrontal cortex ,business.industry ,Cell Biology ,Methamphetamine ,electroencephalogram ,Transcranial magnetic stimulation ,Dorsolateral prefrontal cortex ,Electrophysiology ,medicine.anatomical_structure ,Neural oscillation ,0305 other medical science ,business ,030217 neurology & neurosurgery ,psychological phenomena and processes ,Developmental Biology ,Stroop effect ,medicine.drug - Abstract
BackgroundPrevious studies have identified the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on cravings of patients with methamphetamine use disorder (MUD). However, the mechanism underlying the treatment effect remains largely unknown. A potential candidate mechanism could be that rTMS over the dorsolateral prefrontal cortex (DLPFC) modulates the attention bias to methamphetamine-related cues. The purpose of this study is therefore to determine the modulation of rTMS on methamphetamine-related attention bias and the corresponding electrophysiological changes.MethodsForty-nine patients with severe MUD were included for analysis. The subjects were randomized to receive the active intermittent theta-burst stimulation (iTBS) or sham iTBS targeting DLPFC for 20 sessions. Participants performed the Addiction Stroop Task before and after the treatment while being recorded by a 64-channel electroencephalogram. Baseline characteristics were collected through the Addiction Severity Index.ResultsPost-treatment evaluations showed a reduced error rate in discriminating the color of methamphetamine words in the active iTBS group compared with the sham iTBS group. Following rTMS treatment, we found the significant time-by-group effect for the N1 amplitude (methamphetamine words > neutral words) and P3 latency (methamphetamine words > neutral words). The change of N1 amplitude was positively correlated with cravings in the active group. Moreover, reduced power of neural oscillation in the beta band, manifesting at frontal central areas, was also found in the active group.ConclusionThis study suggests that attention bias and the beta oscillation during the attentional processing of methamphetamine words in patients with MUD could be modulated by iTBS applied to left DLPFC.
- Published
- 2021
31. Diagnosis of chronic prostatitis by noninvasive methods in elderly patients with benign prostatic hyperplasia in China
- Author
-
Qifeng Cao, Ding Xu, Wenbin Guan, Jun Qi, Yunkai Zhu, and Yu Wu
- Subjects
Male ,China ,medicine.medical_specialty ,Urology ,Prostatic Hyperplasia ,030232 urology & nephrology ,Prostatitis ,urologic and male genital diseases ,Logistic regression ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Prostate ,medicine ,Humans ,In patient ,Aged ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Transurethral Resection of Prostate ,General Medicine ,Middle Aged ,Prostate-Specific Antigen ,Hyperplasia ,medicine.disease ,Prostate-specific antigen ,medicine.anatomical_structure ,Transrectal ultrasonography ,business - Abstract
Background: Chronic prostatitis is hard to be identified in benign prostatic hyperplasia (BPH) patients in clinical works. This study aimed to diagnose chronic prostatitis in BPH patients by noninvasive methods.Methods: The research was carried out on the BPH patients who received transurethral resection of prostate at Xinhua hospital from January 2014 to Jul 2015. Before operation, patients were asked for medical history and required to receive physical examination, serum sample collection including PSA, sex hormones, inflammatory cytokines, metabolic panel and transrectal ultrasonography. According to histological results, the patients were divided into 2 group of BPH with/without prostatitis. Logistic regression was used to find the risk factors of chronic prostatitis.Results: As a result, 181 men with an average age of 72.15±8.41 years were enrolled in this study, including 116 patients with prostatitis and 65 patients without prostatitis. The storage sub-score (9.24±1.55 vs 8.52±1.63, p=0.009), PSA (8.23±7.69 vs 4.92±3.84, p=0.005) and IL-2R (531.96±200.75 vs 434.11±153.54, p=0.001) were significantly higher in patients with prostatitis than those without prostatitis. Based on logistic regression analysis, the above three parameters were also the risk factors of BPH with prostatitis. The diagnostic model was calculated as: 0.317* storage sub-score+0.092* PSA+0.003* IL-2R-4.296. The AUC was 0.725. Conclusions: Histological prostatitis in BPH patients can be diagnosed by the combination of serum IL-2R, PSA and storage sub-score. Identification of chronic prostatitis among patients with BPH is beneficial for medical decisions, which can more efficiently alleviate urinary symptoms and reduce the risk of disease progression.
- Published
- 2021
32. Secure communication with joint resource allocation, relay and jammer selection in OFDM‐based cooperative networks
- Author
-
Qi Liu and Ding Xu
- Subjects
Computer Networks and Communications ,business.industry ,Computer science ,Orthogonal frequency-division multiplexing ,Eavesdropping ,law.invention ,Secure communication ,Relay ,law ,Resource allocation ,Electrical and Electronic Engineering ,business ,Joint (audio engineering) ,Selection (genetic algorithm) ,Computer network - Published
- 2021
33. Correlation of prostatic morphological parameters and clinical progression in aging Chinese men with benign prostatic hyperplasia: Results from a cross-sectional study
- Author
-
Subo Qian, Ding Xu, Yu Wu, Weimin Xia, Shun Zhang, Haibo Shen, and Jun Qi
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Aging ,Cross-sectional study ,Urology ,Prostatic Hyperplasia ,03 medical and health sciences ,0302 clinical medicine ,Prostate ,medicine ,Humans ,Cumulative incidence ,Aged ,Retrospective Studies ,Ultrasonography ,Aged, 80 and over ,business.industry ,Retrospective cohort study ,Odds ratio ,Organ Size ,Hyperplasia ,Middle Aged ,medicine.disease ,Confidence interval ,030104 developmental biology ,medicine.anatomical_structure ,Cross-Sectional Studies ,Oncology ,030220 oncology & carcinogenesis ,Disease Progression ,Population study ,business - Abstract
Objectives Our study aimed to investigate the correlation of prostatic morphological parameters and benign prostatic hyperplasia (BPH) clinical progression in aging Chinese men. Methods In this retrospective study, a total of 1038 patients were reviewed. Prostatic morphology was measured by transrectal ultrasound (TRUS). Detailed medical history of all candidates was recorded and analyzed after being classified by specific prostatic measurements. Univariate and multivariate logistic regression analyses were used to estimate the correlation between variables. Results The cumulative incidence of BPH clinical progression was 63.68% (661/1038) in the study population. Prostate volume (PV), transitional zone volume (TZV), transitional zone index (TZI), and intravesical prostatic protrusion (IPP) were all positively associated with BPH progression (all p 60 ml, TZV > 15 ml, TZI > 0.5, or IPP > 5 mm had a significantly higher possibility of overall BPH clinical progression (adjusted odds ratio (OR): 2.485, 1.678, 1.886, and 1.924, respectively; 95% confidence interval (CI): 1.559-3.960, 1.131-2.489, 1.379-2.579, and 1.357-2.728, correspondingly). Conclusion Prostatic morphological parameters are significantly associated with BPH clinical progression. Patients with larger prostatic morphological parameters are more easily prone to clinical progress. As a result, reasonable managements should be timely considered for those patients before clinical progression occurs.
- Published
- 2021
34. Tourists’ spatio-temporal behaviour and concerns in park tourism: Giant Panda National Park, Sichuan, China
- Author
-
Ding Xu, Li Cong, and Geoffrey Wall
- Subjects
business.industry ,National park ,Field (Bourdieu) ,Wildlife tourism ,05 social sciences ,Geography, Planning and Development ,Environmental resource management ,Nature based tourism ,Asia pacific ,Geography ,Tourism, Leisure and Hospitality Management ,0502 economics and business ,050211 marketing ,business ,China ,Recreation ,050212 sport, leisure & tourism ,Tourism - Abstract
To understand the recreational uses of national parks, a field investigation was employed at Giant Panda National Park, Sichuan. Through a mixed-methods approach and visual portrayal of the...
- Published
- 2019
35. Secure Transmission in Wireless Powered Communication Networks with Full-Duplex Receivers
- Author
-
Ding Xu and Qun Li
- Subjects
Computer science ,business.industry ,Applied Mathematics ,Signal Processing ,Wireless ,Electrical and Electronic Engineering ,business ,Computer Graphics and Computer-Aided Design ,Secure transmission ,Telecommunications network ,Computer network - Published
- 2019
36. Energy-Saving Computation Offloading by Joint Data Compression and Resource Allocation for Mobile-Edge Computing
- Author
-
Ding Xu, Qun Li, and Hongbo Zhu
- Subjects
Mobile edge computing ,Computer science ,business.industry ,Distributed computing ,020206 networking & telecommunications ,Cloud computing ,02 engineering and technology ,Energy consumption ,Computer Science Applications ,Modeling and Simulation ,Server ,Convex optimization ,0202 electrical engineering, electronic engineering, information engineering ,Computation offloading ,Resource allocation ,Resource management ,Electrical and Electronic Engineering ,business ,Wireless sensor network ,Edge computing ,Data compression - Abstract
In this letter, we consider a multiuser mobile-edge computing (MEC) system with latency constraint. In order to meet the latency requirement and save energy consumption, each user can partially offload the task to the MEC server for edge computing. Data compression is applied to compress the offloaded data before transmission to reduce the data size. The problem of jointly optimizing computation offloading, data compression and resource allocation to minimize energy consumption under the latency constraint and finite MEC computation capacity is considered. We transform the non-convex problem into a convex one and apply convex optimization to solve it. The simulation results demonstrate that our proposed scheme significantly outperforms the benchmark schemes.
- Published
- 2019
37. Resource allocation in OFDM-based wireless powered communication networks with SWIPT
- Author
-
Qun Li and Ding Xu
- Subjects
Computer Science::Computer Science and Game Theory ,ComputingMethodologies_SIMULATIONANDMODELING ,business.industry ,Orthogonal frequency-division multiplexing ,Computer science ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,020206 networking & telecommunications ,Data_CODINGANDINFORMATIONTHEORY ,02 engineering and technology ,Telecommunications network ,Subcarrier ,03 medical and health sciences ,0302 clinical medicine ,Transmission (telecommunications) ,Telecommunications link ,Computer Science::Networking and Internet Architecture ,0202 electrical engineering, electronic engineering, information engineering ,Wireless ,Resource allocation ,Electrical and Electronic Engineering ,business ,030217 neurology & neurosurgery ,Computer Science::Information Theory ,Computer network ,Data transmission - Abstract
This paper considers a multiuser orthogonal frequency division multiplexing (OFDM)-based wireless powered communication networks (WPCNs) with simultaneous wireless information and power transfer (SWIPT). In particular, both uplink and downlink communications are considered by dividing the time for transmission into downlink and uplink communication phases. In the downlink, SWIPT is adopted at the users with nonlinear energy harvesting model, and in the uplink, users use the harvested energy to perform uplink data transmission. We propose a suboptimal resource allocation scheme to maximize the weighted downlink and uplink sum rate by optimizing the time, subcarrier and power allocation. It is shown that the proposed scheme can well balance between the downlink rate and the uplink rate.
- Published
- 2019
38. Outage Minimized Resource Allocation for Multiuser OFDM Systems With SWIPT
- Author
-
Ding Xu and Hongbo Zhu
- Subjects
energy harvesting ,power splitting ,General Computer Science ,Computer science ,Orthogonal frequency-division multiplexing ,Time division multiple access ,resource allocation ,050801 communication & media studies ,02 engineering and technology ,Data_CODINGANDINFORMATIONTHEORY ,Subcarrier ,0508 media and communications ,Telecommunications link ,0202 electrical engineering, electronic engineering, information engineering ,Electronic engineering ,Wireless ,General Materials Science ,OFDM ,Simultaneous wireless information and power transfer ,business.industry ,05 social sciences ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,General Engineering ,020206 networking & telecommunications ,Transmitter power output ,outage performance ,Resource allocation ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,business ,lcsh:TK1-9971 - Abstract
This paper considers a downlink multiuser orthogonal frequency division multiple (OFDM) system with simultaneous wireless information and power transfer (SWIPT), where the users decode information and harvest energy using the same received downlink signals. In particular, both power splitting (PS) and time switching (TS) SWIPT modes are considered for coordinating information transferring and energy harvesting. For multiuser information transmission, OFDM access (OFDMA) and time division multiple access (TDMA) are adopted for PS-SWIPT and TS-SWIPT, respectively. The outage performance of such a multiuser OFDM system with SWIPT is investigated. Particularly, we optimize the subcarrier allocation, power allocation and PS ratio for PS-SWIPT, and the power allocation and time allocation for TS-SWIPT, aiming at minimizing the fraction of outage over all users under the minimum harvest energy constraint along with the peak and total transmit power constraints. Suboptimal heuristic algorithms are obtained based on the Lagrange duality method. The outage performances of PS-SWIPT and TS-SWIPT are compared under various system parameter settings. We show that the outage performance of TS-SWIPT is better than that of the PS-SWIPT, except when the minimum required harvested energy is large, the total transmit power limit is small, or the number of users is small.
- Published
- 2019
39. Jammer-Assisted Legitimate Eavesdropping in Wireless Powered Suspicious Communication Networks
- Author
-
Qun Li, Ding Xu, and Hongbo Zhu
- Subjects
energy harvesting ,Information transfer ,General Computer Science ,Computer science ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,General Engineering ,Jamming ,Eavesdropping ,Broadcasting ,Transmitter power output ,Computer security ,computer.software_genre ,Legitimate eavesdropping ,Wireless ,General Materials Science ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,business ,Performance metric ,computer ,jamming ,lcsh:TK1-9971 ,Power control ,wireless powered suspicious communication network - Abstract
To enhance public safety, it is necessary to legitimately eavesdrop communication between suspicious users, such as terrorists and criminals. In this paper, we investigate legitimate eavesdropping in a wireless-powered suspicious communication network (WPSCN) with a wireless-powered suspicious transmitter and a suspicious receiver, who is legitimately eavesdropped by a legitimate monitor with the help from a wireless-powered friendly jammer. The “harvest-then-transmit” protocol is adopted by the suspicious communication to coordinate wireless energy transfer and information transfer. Both the suspicious receiver and the legitimate monitor can act as power sources for the suspicious transmitter and the jammer. The legitimate monitor can control the suspicious communication rate by broadcasting power signals, while the jammer can harvest energy and then interfere with the suspicious communication in collaboration with the legitimate monitor. Four different metrics are adopted to evaluate the eavesdropping performance based on different application requirements, and they are the successful eavesdropping probability, the average eavesdropping rate, the relative eavesdropping rate, and the eavesdropping energy efficiency. For each performance metric, we derive the optimal transmit power of the monitor for energy transfer and the optimal jamming transmit power of the jammer to maximize the performance metric under the peak transmit power constraint at the monitor and the energy causality constraint at the jammer. Some important insights are derived from these optimal power control policies. The simulations are conducted to verify the proposed optimal power control for legitimate eavesdropping in the WPSCN. It is shown that the proposed optimal power control policies greatly outperform other benchmark schemes.
- Published
- 2019
40. The influence of hook tip in different depths on the acromioclavicular joint dislocation treated with clavicular hook plate: A retrospective study
- Author
-
Weigang Lou, Jianming Chen, Ming Li, and Ding Xu
- Subjects
Orthodontics ,Hook ,Efficacy ,RD1-811 ,business.industry ,Acromioclavicular joint dislocation ,Shoulder Dislocation ,Hook plate ,Treatment Outcome ,medicine.anatomical_structure ,Acromioclavicular Joint ,Influence ,medicine ,Humans ,Acromioclavicular joint ,Surgery ,Dislocation ,Hook tip depth ,business ,Bone Plates ,Complication ,Retrospective Studies - Published
- 2021
41. Secure Communications for Primary Users in Cognitive Radio Networks with Collusive Eavesdroppers
- Author
-
Ding Xu and Qun Li
- Subjects
Primary (chemistry) ,business.industry ,Computer science ,Applied Mathematics ,020302 automobile design & engineering ,020206 networking & telecommunications ,02 engineering and technology ,Computer Graphics and Computer-Aided Design ,Cognitive radio ,0203 mechanical engineering ,Signal Processing ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,business ,Computer network - Published
- 2018
42. Hidden blood loss and its risk factors after hip hemiarthroplasty for displaced femoral neck fractures: a cross-sectional study
- Author
-
Wei-Jun Guo, Ji-Qi Wang, Weikang Wang, Wei-Jiang Zhang, Peng Luo, and Ding Xu
- Subjects
Male ,medicine.medical_specialty ,Gastrointestinal bleeding ,Cross-sectional study ,Blood Loss, Surgical ,Hematocrit ,Femoral Neck Fractures ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Bayesian multivariate linear regression ,Linear regression ,medicine ,Humans ,ddc:610 ,030212 general & internal medicine ,Aged ,Femoral neck ,Aged, 80 and over ,030222 orthopedics ,medicine.diagnostic_test ,Fracture Dislocation ,business.industry ,General Medicine ,Perioperative ,medicine.disease ,Surgery ,Cross-Sectional Studies ,medicine.anatomical_structure ,Clinical Interventions in Aging ,Female ,Hemiarthroplasty ,Geriatrics and Gerontology ,business - Abstract
Clinical interventions in aging Volume 13, 1639-1645 (2018). doi:10.2147/CIA.S174196, Published by DOVE Medical Press, Albany, Auckland
- Published
- 2018
43. A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy
- Author
-
Qian Shen, Rong Li, Lei Xu, Phei Er Saw, Yusheng Zhou, Guang Wu, Senlin Li, and Xiao-Ding Xu
- Subjects
Cell Membrane Permeability ,Time Factors ,Saporin ,Endosome ,Polymers ,Drug Compounding ,Antineoplastic Agents ,Apoptosis ,Breast Neoplasms ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Catalysis ,Mice ,Breast cancer ,Nanocapsules ,In vivo ,Cell Line, Tumor ,Materials Chemistry ,Tumor Microenvironment ,Medicine ,Cytotoxic T cell ,Animals ,Humans ,Tumor microenvironment ,biology ,business.industry ,Metals and Alloys ,General Chemistry ,Neoplasms, Experimental ,Hydrogen-Ion Concentration ,021001 nanoscience & nanotechnology ,medicine.disease ,Saporins ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Cytosol ,Drug Liberation ,Ceramics and Composites ,biology.protein ,Cancer research ,lipids (amino acids, peptides, and proteins) ,Female ,0210 nano-technology ,business ,Intracellular - Abstract
Intracellular delivery of therapeutic proteins remains a challenge for the success of protein-mediated disease treatment. We herein develop a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compound G0-C14 for in vivo delivery of cytotoxic saporin and breast cancer therapy. This nanoplatform could respond to a TME pH to rapidly release saporin/G0-C14 complexes, which could significantly improve the uptake of cytosolic saporin by tumor cells and subsequent endosomal escape, thereby leading to an effective inhibition of tumor growth.
- Published
- 2021
44. Resveratrol could attenuate prostatic inflammation in rats with Oestradiol‐induced chronic prostatitis
- Author
-
Zhengqin Gu, Wenbin Guan, Ding Xu, Xiaoqiang Qian, and Jun Qi
- Subjects
Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Prostatic Stroma ,Prostatitis ,Inflammation ,Resveratrol ,Proinflammatory cytokine ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,medicine ,Animals ,Humans ,Saline ,Estradiol ,Tumor Necrosis Factor-alpha ,business.industry ,General Medicine ,Hyperplasia ,medicine.disease ,Rats ,chemistry ,Immunohistochemistry ,medicine.symptom ,business - Abstract
To evaluate the effect of resveratrol in rats with chronic prostatitis, 24 rats were randomly divided into the negative control, vehicle-treated and resveratrol groups. The rats in the vehicle-treated group and the resveratrol group were injected subcutaneously with 17-β-oestradiol (0.25 mg/kg) daily for 6 weeks while the rats in the control group were injected with equivalent normal saline. From the 45th day, the rats in the resveratrol group were given resveratrol (10 mg/kg) by gavage per day while the rest rats were given normal saline. After 55 days, all the rats were sacrificed and the prostatic tissue was removed. Morphological changes were examined by light microscope after H&E staining. The expressions of IL-6, IL-8 and TNF-α were determined through ELISA and immunohistochemical staining. As a result, significant inflammatory cell infiltration and fibroblastic hyperplasia were observed in prostatic stroma in the vehicle-treated group compared with the negative control group, as well as the high expression of IL-6, IL-8 and TNF-α. After resveratrol treatment, inflammatory cell infiltration and fibroblastic hyperplasia were shown prominently reduced. Meanwhile, the expression of IL-6, IL-8 and TNF-α was significantly suppressed. For conclusion, resveratrol could attenuate the prostatic inflammation and downregulate the expression of IL-6, IL-8 and TNF-α in rat with oestradiol-induced chronic prostatitis.
- Published
- 2021
45. Serum interleukin 6 and acute urinary retention in elderly men with benign prostatic hyperplasia in China: a cross-sectional study
- Author
-
Zhi-En Shi, Di Wu, Subo Qian, Ding Xu, Yu Wu, and Jun Qi
- Subjects
medicine.medical_specialty ,Receiver operating characteristic ,Urinary retention ,business.industry ,Cross-sectional study ,Urology ,030232 urology & nephrology ,Area under the curve ,Odds ratio ,Logistic regression ,Gastroenterology ,Confidence interval ,03 medical and health sciences ,0302 clinical medicine ,Reproductive Medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Original Article ,medicine.symptom ,Prospective cohort study ,business - Abstract
BACKGROUND: While acute urinary retention (AUR) is a severe complication of benign prostatic hyperplasia (BPH), it can also indicate the progression of this common disease in aging men. This study aimed at exploring the possible relationship between serum interleukin 6 (sIL-6) and AUR in BPH patients. METHODS: A cross-sectional study was conducted based on 256 elderly men with BPH in China. The association between the sIL-6 level and the occurrence of AUR was evaluated by univariate and multivariable logistic regressions. The receiver operating characteristic (ROC) curve was utilized to determine the discriminant validity of the sIL-6 level and the optimal cut-off value. RESULTS: The concentration of sIL-6 was significantly elevated in the AUR group (P
- Published
- 2021
46. Retinal Microvascular Changes in Subtypes of Ischemic Stroke
- Author
-
Ying Zhao, Bing Yang, An-Ding Xu, Yi-Wen Ruan, Ying Xu, Hui-Ling Hu, and Ze-Feng Tan
- Subjects
medicine.medical_specialty ,Fundus (eye) ,lcsh:RC346-429 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,ischemic stroke ,medicine ,Prospective cohort study ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,neurolucida ,Receiver operating characteristic ,business.industry ,subtypes ,venular diameter ,Retinal ,Confidence interval ,Small artery ,Neurology ,chemistry ,retinal microvascular changes ,Hospital admission ,Ischemic stroke ,030221 ophthalmology & optometry ,Cardiology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Aims: Retinal microvasculature shares prominent similarities with the brain vasculature. We aimed to assess the association between retinal microvasculature and subtypes of ischemic stroke.Method: We consecutively enrolled ischemic stroke patients within 7 days of onset, who met the criteria of subtype of atherothrombosis (AT), small artery disease (SAD), or cardioembolism (CE) according to a modified version of the Trial of Org 10172 in Acute Stroke Treatment (NEW-TOAST). Digital fundus photographs were taken within 72 h of hospital admission using a digital camera (Topcon TRC-50DX), and fundus photographs were semi-automatically measured by software (Canvus 14 and NeuroLucida) for retinal vasculature parameters.Results: A total of 141 patients were enrolled, including 72 with AT, 54 with SAD, and 15 with CE. AT subtype patients had the widest mean venular diameter within 0.5–1.0 disk diameter (MVD0.5−1.0DD) followed by SAD and CE subtypes (86.37 ± 13.49 vs. 83.55 ± 11.54 vs. 77.90 ± 8.50, respectively, P = 0.047); CE subtype patients had the highest mean arteriovenous ratio within 0.5–1.0 disk diameter (MAVR0.5−1.0DD) followed by the AT and SAD subtype groups (0.97 ± 0.03 vs. 0.89 ± 0.99 vs. 0.89 ± 0.11, respectively, P = 0.010); SAD subtype patients were found with the highest mean venular tortuosity within 0.0–2.0 disk diameter (MVT0.0−2.0DD) followed by the AT and CE subtypes (1.0294 ± 0.0081 vs. 1.0259 ± 0.0084 vs. 1.0243 ± 0.0066, respectively, P = 0.024). After adjusting for clinic characteristics, MVD0.5−1.0DD was significantly different among AT, SAD, and CE subtypes (P = 0.033). By receiver operating characteristic curve analysis, MVD0.5−1.0DD predicted the AT subtype (area 0.690, 95% confidence interval, 0.566–0.815), with a cutoff value of 82.23 μm (sensitivity 61.1%, specificity 73.3%).Conclusion: Retinal MVD0.5−1.0DD (>82.23 μm) might be associated with the AT stroke subtype; however, we need large-scale prospective studies in future to explore the underlying mechanism and causal explanation for this finding.
- Published
- 2021
47. Long-Term Effects of Mind-Body Exercises on the Physical Fitness and Quality of Life of Individuals With Substance Use Disorder—A Randomized Trial
- Author
-
Dong Zhu, Mei Jiang, Ding Xu, and Wolfgang I. Schöllhorn
- Subjects
medicine.medical_specialty ,lcsh:RC435-571 ,medicine.medical_treatment ,Physical fitness ,rehabilitation ,law.invention ,qi gong ,Randomized controlled trial ,Quality of life ,law ,lcsh:Psychiatry ,Medicine ,Aerobic exercise ,mind-body exercise ,methamphetamine ,Psychiatry ,Rehabilitation ,business.industry ,Repeated measures design ,medicine.disease ,Clinical Trial ,Substance abuse ,Psychiatry and Mental health ,Blood pressure ,quality of life ,yoga ,tai chi ,Physical therapy ,business ,heroin - Abstract
Background: Mind-body exercises (MBE) are sequences of low to medium-intensity activities that benefit healthy performers physically and mentally. In contrast to the unmodified application of traditional tai chi, qi gong, or yoga in the healthy population, MBEs are typically tailored for individuals with substance abuse disorder (SUD). Despite numerous applications in practice, the detailed effects of tailor-made MBEs for SUD are unclear.Objectives: This study aimed to analyze and compare changes in the physical fitness and quality of life of individuals with SUD that underwent conventional or tailor-made MBEs.Methods: A total of 100 subjects obtained from the Shanghai Mandatory Detoxification and Rehabilitation Center with SUD were randomly assigned into two groups. The subjects in the experimental group (n = 50) practiced tailored MBE for 60 min a day, five times a week, for 3 months. The subjects (n = 50) in the control group were treated with conventional rehabilitation exercises with the same intervention protocol. The outcomes of fitness and quality of life for drug addiction were measured at the beginning and after 3 and 6 months by a questionnaire (QOL-DA). A two-way repeated measure analysis of variance was applied to compare the difference of treatments in the two groups.Results: Statistically significant differences for the experimental group were found in systolic (p < 0.01, η2 = 0.124) and diastolic blood pressure (p < 0.01, η2 = 0.097), pulse (p < 0.01, η2 = 0.086), vital capacity (p < 0.05, η2 = 0.036), flexibility (p < 0.01, η2 = 0.143), and aerobic endurance (p < 0.01, η2 = 0.165). Results of the QOL-DA showed statistically significant differences between the experimental and control groups in total score (p < 0.01, η2 = 0.158) with greater effects on the former.Conclusions: This study provided evidence that tailored MBE could lead to remarkable effects with regard to blood pressure, vital capacity, flexibility, and aerobic endurance in comparison with conventional rehabilitation methods.Clinical Trial Registration: ChiCTR-IPR-14005343.
- Published
- 2020
48. Antimicrobial Resistance Risk Assessment Models and Database System for Animal-Derived Pathogens
- Author
-
Ding Xu, Buwen Liang, Congming Wu, Yongjun Zheng, Xinxing Li, and Jianping Li
- Subjects
0301 basic medicine ,Microbiology (medical) ,microbial ,030106 microbiology ,Disease ,Drug resistance ,010501 environmental sciences ,computer.software_genre ,01 natural sciences ,Biochemistry ,Microbiology ,Article ,03 medical and health sciences ,Human health ,Risk area ,Antibiotic resistance ,Medicine ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,Antibiotic use ,0105 earth and related environmental sciences ,drug resistance ,Database ,business.industry ,lcsh:RM1-950 ,risk assessment ,second-order Monte Carlo method ,lcsh:Therapeutics. Pharmacology ,Infectious Diseases ,DRI ,Disease risk ,Risk assessment ,business ,computer ,database system - Abstract
(1) Background: The high use of antibiotics has made the issue of antimicrobial resistance (AMR) increasingly serious, which poses a substantial threat to the health of animals and humans. However, there remains a certain gap in the AMR system and risk assessment models between China and the advanced world level. Therefore, this paper aims to provide advanced means for the monitoring of antibiotic use and AMR data, and take piglets as an example to evaluate the risk and highlight the seriousness of AMR in China. (2) Methods: Based on the principal component analysis method, a drug resistance index model of anti-E. coli drugs was established to evaluate the antibiotic risk status in China. Additionally, based on the second-order Monte Carlo methods, a disease risk assessment model for piglets was established to predict the probability of E. coli disease within 30 days of taking florfenicol. Finally, a browser/server architecture-based visualization database system for animal-derived pathogens was developed. (3) Results: The risk of E. coli in the main area was assessed and Hohhot was the highest risk area in China. Compared with the true disease risk probability of 4.1%, the result of the disease risk assessment model is 7.174%, and the absolute error was 3.074%. Conclusions: Taking E. coli as an example, this paper provides an innovative method for rapid and accurate risk assessment of drug resistance. Additionally, the established system and assessment models have potential value for the monitoring and evaluating AMR, highlight the seriousness of antimicrobial resistance, advocate the prudent use of antibiotics, and ensure the safety of animal-derived foods and human health.
- Published
- 2020
49. Deep-learning-based anomaly detection for lace defect inspection employing videos in production line
- Author
-
Ding Xu, Bingyu Lu, and Biqing Huang
- Subjects
Production line ,Pixel ,Computer science ,business.industry ,Deep learning ,Building and Construction ,Thresholding ,Image (mathematics) ,Visual inspection ,Artificial Intelligence ,Computer vision ,Anomaly detection ,Artificial intelligence ,Weaving ,business ,Information Systems - Abstract
Defect inspection plays an essential role in ensuring quality of industrial products. The most widely used human visual inspection method has some drawbacks such as high cost and low efficiency, which bring an eager demand for the application of automatic defect inspection algorithm in actual production. However, few industrial production lines use automatic detection devices due to the gap between data collected in the actual production environment and ready-made datasets. Lace is one of the industrial products which completely depends on manual defect inspection. The complex and fine texture of lace makes it difficult to extract regular patterns using the existing image-based defect inspection methods. In this paper, we propose to collect lace videos in the weaving stage and design a deep-learning-based anomaly detection framework to detect lace defects. The framework contains three stages, namely video pre-processing stage, pixel reconstruction stage and pixel classification stage. In the offline phase, only defect-free lace videos are needed to train the pixel reconstruction model and calculate the detection threshold by our adaptive thresholding method. In the online phase, the proposed framework reconstructs lace videos and performs defect inspection using reconstruction error and the pre-set threshold. As far as we know, this paper the first to detect fabric defects by videos. Experimental results on artificial defect videos demonstrate the effectiveness of the proposed framework.
- Published
- 2022
50. ROS-scavenging hybrid hydrogel for genetically engineered stem cell delivery and limb ischemia therapy
- Author
-
Linzhuo Huang, Phei Er Saw, Qiuling Xiang, Xiao-Ding Xu, Chi Zhang, Zhen Zhang, Qianqian Zhao, Yangyang Chen, and Senlin Li
- Subjects
Angiogenesis ,business.industry ,General Chemical Engineering ,medicine.medical_treatment ,Cell ,Mesenchymal stem cell ,General Chemistry ,Stem-cell therapy ,Industrial and Manufacturing Engineering ,medicine.anatomical_structure ,medicine ,Cancer research ,Environmental Chemistry ,Stem cell ,Signal transduction ,business ,PI3K/AKT/mTOR pathway ,Type I collagen - Abstract
Stem cell therapy is a promising strategy for the treatment of ischemic diseases such as critical limb ischemia (CLI). The major obstacle is the poor survival rate and low efficiency of the implanted stem cells. Biomimetic scaffolds such as injectable hydrogels have shown the ability to promote cell retention and survival. However, the local ischemic microenvironment especially the high level of reactive oxygen species (ROS) usually induces cell loss and dysfunction, thereby leading to unsatisfactory therapeutic outcomes. Herein, we developed a new injectable hybrid hydrogel composed of natural type I collagen and melanin nanoparticles (MeNPs) for the delivery of Gremlin1 (Grem1)-overexpressed mesenchymal stem cells (Grem1-MSCs) and CLI therapy. After local injection of this cell delivery system into the ischemic limbs of mice, the thermal-triggered in situ gelation of collagen could maintain Grem1-MSCs at the injection site and MeNPs entrapped in the hydrogel framework could modulate the ischemic microenvironment via scavenging ROS to promote the survival of implanted stem cells. With this improved cell retention and survival, Grem1-MSCs could constantly secrete high concentration of Grem1, a newly discovered proangiogenic factor that can promote angiogenesis by activating the phosphoinositide 3-kinase (PI3K)-AKT signaling pathway, thereby leading to improved blood perfusion in the ischemic limbs and superior limb salvage. The strategy developed herein offers a promising therapeutic option for the effective cell-based treatment of ischemic diseases.
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.