1. Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
- Author
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Gabriella Fabbrocini, Caterina Missero, Roberta Russo, Monica Gelzo, Aurora Daniele, Maurizio D’Abbraccio, Immacolata Andolfo, Giuseppe Castaldo, Marianna Caterino, Roberto Parrella, Mario Capasso, Chiara Dell’Isola, Stefano Sol, Giuseppe Fiorentino, Anna Annunziata, Ivan Gentile, Emanuela Marchese, Margherita Ruoppolo, Rita Polito, Cecilia Calabrese, Francesco Maria Fusco, Roberta Fedele, Michele Costanzo, Caterino, M., Gelzo, M., Sol, S., Fedele, R., Annunziata, A., Calabrese, C., Fiorentino, G., D'Abbraccio, M., Dell'Isola, C., Fusco, F. M., Parrella, R., Fabbrocini, G., Gentile, I., Andolfo, I., Capasso, M., Costanzo, M., Daniele, A., Marchese, E., Polito, R., Russo, R., Missero, C., Ruoppolo, M., Castaldo, G., Caterino, M, Gelzo, M, Sol, S, Fedele, R, Annunziata, A, Calabrese, C, Fiorentino, G, D'Abbraccio, M, Dell'Isola, C, Fusco, Fm, Parrella, R, Fabbrocini, G, Gentile, I, Andolfo, I, Capasso, M, Costanzo, M, Daniele, A, Marchese, E, Polito, R, Russo, R, Missero, C, and Ruoppolo, M
- Subjects
Male ,Science ,medicine.medical_treatment ,Diseases ,Disease ,medicine.disease_cause ,Severity of Illness Index ,Biochemistry ,Virus ,Article ,Proinflammatory cytokine ,Pathogenesis ,Intensive care ,medicine ,Alarmins ,Humans ,Least-Squares Analysis ,Cytokine ,Coronavirus ,Least-Squares Analysi ,Multidisciplinary ,Molecular medicine ,business.industry ,SARS-CoV-2 ,COVID-19 ,Discriminant Analysis ,Lipid metabolism ,Lipid ,Middle Aged ,Lipid Metabolism ,Lipids ,Alarmin ,Immunology ,Medicine ,Cytokines ,Female ,Discriminant Analysi ,business ,Human ,Biotechnology - Abstract
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing the development of many complementary approaches to identify candidate cellular pathways involved in disease progression. Host lipids play a critical role in the virus life, being the double-membrane vesicles a key factor in coronavirus replication. Moreover, lipid biogenesis pathways affect receptor-mediated virus entry at the endosomal cell surface and modulate virus propagation. In this study, targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement were carried out in serum of COVID-19 patients characterized by different severity degree. Serum IL-26, a cytokine involved in IL-17 pathway, TSLP and adiponectin were measured and correlated to lipid COVID-19 patient profiles. These results could be important for the classification of the COVID-19 disease and the identification of therapeutic targets.
- Published
- 2020