1. Interleukin-1 blocking agents as promising strategy for prevention of anticancer drug-induced cardiotoxicities: possible implications in cancer patients with COVID-19.
- Author
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Quagliariello V, Paccone A, Iovine M, Cavalcanti E, Berretta M, Maurea C, Canale ML, and Maurea N
- Subjects
- Anthracyclines adverse effects, Anthracyclines therapeutic use, Antibodies, Monoclonal, Humanized immunology, Antineoplastic Agents therapeutic use, COVID-19 virology, Cardiotoxicity etiology, Cardiovascular Diseases prevention & control, Humans, Interleukin-1beta immunology, Neoplasms complications, SARS-CoV-2 isolation & purification, Antibodies, Monoclonal, Humanized therapeutic use, Antineoplastic Agents adverse effects, COVID-19 complications, Cardiotoxicity prevention & control, Interleukin-1beta metabolism, Neoplasms drug therapy
- Abstract
Cytokines in cardiac tissue plays a key role in progression of cardiometabolic diseases and cardiotoxicity induced by several anticancer drugs. Interleukin-1β is one on the most studied regulator of cancer progression, survival and resistance to anticancer treatments. Recent findings indicate that interleukin1-β exacerbates myocardial damages in cancer patients treated with chemotherapies and immune check-point inhibitors. Interleukin1-β blocking agent canakinumab reduces major adverse cardiovascular events and cardiovascular death in recent cardiovascular trials. We focalized on the main biological functions of interleukin1-β in cancer and cardiovascular diseases, summarizing the main clinical evidence available to date in literature. Especially in the era of SARS-CoV-2 infection, associated to coagulopathies, myocarditis and heart failure, cancer patients have an increased risk of cardiovascular complications compared to general population, therefore, the pharmacological inhibition of interleukin1-β should be discussed and considered.
- Published
- 2021
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