1. Photoactive electrospun fibers for inducing cell death.
- Author
-
Gabriel D, Cohen-Karni T, Huang D, Chiang HH, and Kohane DS
- Subjects
- Animals, Cell Line, Mice, NIH 3T3 Cells, Photochemical Processes, Polyesters pharmacology, Polylysine pharmacology, Spectrometry, Fluorescence, Cell Death drug effects, Electrochemical Techniques instrumentation, Electrochemical Techniques methods
- Abstract
A photoactive electrospun material producing reactive oxygen species (ROS) upon light irradiation is reported. The phototoxicity of the generated ROS is spatially restricted to the fiber-tissue interface by conjugation of the photosensitizer to a macromolecule. Photo-triggered ROS is produced on demand and repeatedly. It induces death of mammalian cells growing on the material surface with high spatial resolution., (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2014
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