1. Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome
- Author
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Yong Yao, Hongwen Zhang, Huijie Xiao, Jie Ding, Baige Su, Xuhui Zhong, Na Guan, Fang Wang, and Xiaoyu Liu
- Subjects
Male ,Nephrology ,medicine.medical_specialty ,Nephrotic Syndrome ,Time Factors ,Adolescent ,Leukocytosis ,Physiology ,030232 urology & nephrology ,Urine ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Renal Dialysis ,Risk Factors ,Physiology (medical) ,Internal medicine ,Leukocytes ,medicine ,Humans ,Child ,Survival analysis ,Retrospective Studies ,urogenital system ,business.industry ,Acute kidney injury ,Recovery of Function ,Acute Kidney Injury ,Prognosis ,medicine.disease ,female genital diseases and pregnancy complications ,Single centre ,Kidney Tubules ,Child, Preschool ,Female ,business ,Nephrotic syndrome - Abstract
The prognosis of acute kidney injury (AKI) varies in children with nephrotic syndrome (NS), data on factors predicting the recovery and recurrence of AKI in children with NS are limited. This study aimed to explore the possible factors predicting the recovery from and recurrence of AKI in children with primary NS. Children with primary NS complicated with AKI from 1993 to 2017 in a single centre were reviewed retrospectively. The clinical pictures and possible factors predicting the recovery from and recurrence of AKI in children with primary NS were investigated. Sixty-eight episodes of AKI in 59 children with NS were analysed: 88.2% of AKI recovered within 3 months, and 2.9% of AKI did not recover after 3 months. Survival analysis revealed that leucocyturia is significantly related to the AKI recovery time (P = 0.001), and children with leucocyturia [22 (4, 79) days] recovered significantly slower than did children without leucocyturia [12.0 (2, 39) days]. Renal tubular and interstitial injury were prominent in children with leucocyturia, and 11.9% of children with index AKI experienced the recurrence of AKI. Most episodes of AKI that occurred in children with NS recovered completely. Leucocyturia is a significant factor predicting the recovery time of AKI.
- Published
- 2021