13 results on '"Allen, Naomi"'
Search Results
2. Genetic, lifestyle, and health-related characteristics of adults without celiac disease who follow a gluten-free diet: a population-based study of 124,447 participants.
- Author
-
Littlejohns, Thomas J, Chong, Amanda Y, Allen, Naomi E, Arnold, Matthew, Bradbury, Kathryn E, Mentzer, Alexander J, Soilleux, Elizabeth J, and Carter, Jennifer L
- Subjects
LIFESTYLES ,GENETICS ,CONFIDENCE intervals ,CROSS-sectional method ,HEALTH status indicators ,COMPARATIVE studies ,SEX distribution ,POVERTY areas ,GENOMES ,DESCRIPTIVE statistics ,ODDS ratio ,PHENOTYPES ,GLUTEN-free diet ,EDUCATIONAL attainment ,ADULTS - Abstract
Background The number of gluten-free diet followers without celiac disease (CD) is increasing. However, little is known about the characteristics of these individuals. Objectives We address this issue by investigating a wide range of genetic and phenotypic characteristics in association with following a gluten-free diet. Methods The cross-sectional association between lifestyle and health-related characteristics and following a gluten-free diet was investigated in 124,447 women and men aged 40–69 y from the population-based UK Biobank study. A genome-wide association study (GWAS) of following a gluten-free diet was performed. Results A total of 1776 (1.4%) participants reported following a gluten-free diet. Gluten-free diet followers were more likely to be women, nonwhite, highly educated, living in more socioeconomically deprived areas, former smokers, have lost weight in the past year, have poorer self-reported health, and have made dietary changes as a result of illness. Conversely, these individuals were less likely to consume alcohol daily, be overweight or obese, have hypertension, or use cholesterol-lowering medication. Participants with hospital inpatient diagnosed blood and immune mechanism disorders (OR: 1.62; 95% CI: 1.18, 2.21) and non-CD digestive system diseases (OR: 1.58; 95% CI: 1.42, 1.77) were more likely to follow a gluten-free diet. The GWAS demonstrated that no genetic variants were associated with being a gluten-free diet follower. Conclusions Gluten-free diet followers have a better cardiovascular risk profile than non-gluten-free diet followers but poorer self-reported health and a higher prevalence of blood and immune disorders and digestive conditions. Reasons for following a gluten-free diet warrant further investigation. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition.
- Author
-
Costas, Laura, Lujan-Barroso, Leila, Benavente, Yolanda, Allen, Naomi E, Amiano, Pilar, Ardanaz, Eva, Besson, Caroline, Boeing, Heiner, Bueno-de-Mesquita, Bas, Cervenka, Iris, Fortner, Renée T, Fournier, Agnès, Gunter, Marc, Harlid, Sophia, Huerta, José María, Jerkeman, Mats, Jirström, Karin, Kaaks, Rudolf, Karakatsani, Anna, and Khaw, Kay-Tee
- Subjects
B cell lymphoma ,CONFIDENCE intervals ,HORMONES ,SEX hormones ,HUMAN reproduction ,LONGITUDINAL method ,MENOPAUSE ,MULTIVARIATE analysis ,THERAPEUTICS ,PROPORTIONAL hazards models ,ODDS ratio ,TUMOR risk factors - Abstract
The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992–2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
4. Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies.
- Author
-
Allen, Naomi E., Travis, Ruth C., Appleby, Paul N., Albanes, Demetrius, Barnett, Matt J., Black, Amanda, Bueno-de-Mesquita, H. Bas, Deschasaux, Mélanie, Galan, Pilar, Goodman, Gary E., Goodman, Phyllis J., Gunter, Marc J., Heliövaara, Markku, Helzlsouer, Kathy J., Henderson, Brian E., Hercberg, Serge, Knekt, Paul, Kolonel, Laurence N., Lasheras, Christina, and Linseisen, Jakob
- Subjects
- *
PHYSIOLOGICAL effects of selenium , *PROSTATE cancer risk factors , *LOGISTIC regression analysis , *DISEASE progression , *CONFIDENCE intervals , *BLOOD sampling , *SELENIUM analysis , *LONGITUDINAL method , *NAILS (Anatomy) , *PROBABILITY theory , *PROSTATE tumors , *RESEARCH funding , *RISK assessment , *SELENIUM , *TOES , *CASE-control method - Abstract
Background: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade.Methods: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk. Odds ratios of prostate cancer by selenium concentration were estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided.Results: Blood selenium was not associated with the risk of total prostate cancer (multivariable-adjusted odds ratio [OR] per 80 percentile increase = 1.01, 95% confidence interval [CI] = 0.83 to 1.23, based on 4527 case patients and 6021 control subjects). However, there was heterogeneity by disease aggressiveness (ie, advanced stage and/or prostate cancer death, Pheterogeneity = .01), with high blood selenium associated with a lower risk of aggressive disease (OR = 0.43, 95% CI = 0.21 to 0.87) but not with nonaggressive disease. Nail selenium was inversely associated with total prostate cancer (OR = 0.29, 95% CI = 0.22 to 0.40, Ptrend < .001, based on 1970 case patients and 2086 control subjects), including both nonaggressive (OR = 0.33, 95% CI = 0.22 to 0.50) and aggressive disease (OR = 0.18, 95% CI = 0.11 to 0.31, Pheterogeneity = .08).Conclusions: Nail, but not blood, selenium concentration is inversely associated with risk of total prostate cancer, possibly because nails are a more reliable marker of long-term selenium exposure. Both blood and nail selenium concentrations are associated with a reduced risk of aggressive disease, which warrants further investigation. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
5. First-Morning Urinary Melatonin and Breast Cancer Risk in the Guernsey Study.
- Author
-
Wang, Xiao-Si, Tipper, Sarah, Appleby, Paul N., Allen, Naomi E., Key, Timothy J., and Travis, Ruth C.
- Subjects
BREAST tumor risk factors ,CANCER patients ,COMPARATIVE studies ,CONFIDENCE intervals ,STATISTICAL correlation ,EPIDEMIOLOGY ,MELATONIN ,RESEARCH funding ,T-test (Statistics) ,LOGISTIC regression analysis ,DATA analysis ,CASE-control method ,DESCRIPTIVE statistics ,NULL hypothesis - Abstract
It has been hypothesized that suppressed nocturnal melatonin production is associated with an increased risk of breast cancer, but results from several small prospective studies of the association have been inconclusive. We examined the association between nocturnal melatonin and breast cancer risk in a case-control study nested within the Guernsey III Study, a British prospective cohort study (1977–2009). Concentrations of 6-sulfatoxymelatonin were measured in prediagnostic first-morning urine samples from 251 breast cancer cases and 727 matched controls. Conditional logistic regression models were used to calculate odds ratios for breast cancer in relation to 6-sulfatoxymelatonin level. No significant association was found between 6-sulfatoxymelatonin level and breast cancer risk, either overall (for highest third vs. lowest, multivariable-adjusted odds ratio = 0.90, 95% confidence interval: 0.61, 1.33) or by menopausal status. However, in a meta-analysis of all published prospective data, including 1,113 cases from 5 studies, higher 6-sulfatoxymelatonin levels were associated with lower breast cancer risk (for highest fourth vs. lowest, odds ratio = 0.81, 95% confidence interval: 0.66, 0.99). In summary, we found no evidence that 6-sulfatoxymelatonin level in a first-morning urine sample was associated with breast cancer risk among British women. However, overall the published data suggest a modest inverse association between melatonin levels and breast cancer risk. Further data are needed to confirm this association. [ABSTRACT FROM PUBLISHER]
- Published
- 2014
- Full Text
- View/download PDF
6. Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort—A Factor Analysis.
- Author
-
Dossus, Laure, Lukanova, Annekatrin, Rinaldi, Sabina, Allen, Naomi, Cust, Anne E., Becker, Susen, Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Chabbert-Buffet, Nathalie, Mesrine, Sylvie, Clavel-Chapelon, Francoise, Teucher, Birgit, Chang-Claude, Jenny, Boeing, Heiner, Drogan, Dagmar, Trichopoulou, Antonia, Benetou, Vasiliki, Bamia, Christina, and Palli, Domenico
- Subjects
ENDOMETRIAL tumors ,BIOMARKERS ,BLOOD testing ,COMPARATIVE studies ,CONFIDENCE intervals ,STATISTICAL correlation ,EPIDEMIOLOGY ,FACTOR analysis ,HORMONES ,INFLAMMATION ,INSULIN resistance ,LONGITUDINAL method ,METABOLISM ,RESEARCH funding ,SEX distribution ,STEROIDS ,DATA analysis ,SECONDARY analysis ,POSTMENOPAUSE ,DESCRIPTIVE statistics ,TUMOR risk factors - Abstract
A “Western” lifestyle characterized by physical inactivity and excess weight is associated with a number of metabolic and hormonal dysregulations, including increased circulating estrogen levels, hyperinsulinemia, hyperglycemia, and chronic inflammation. The same hormonal and metabolic axes might mediate the association between this lifestyle and the development of endometrial cancer. Using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study carried out in 10 European countries during 1992–2000, we conducted a factor analysis to delineate important components that summarize the variation explained by a set of biomarkers and to examine their association with endometrial cancer risk. Prediagnostic levels of testosterone, androstenedione, dehydroepiandrosterone sulfate, sex hormone-binding globulin, estrone, estradiol, C-peptide, insulin-like growth factor-binding proteins 1 and 2, adiponectin, high- and low-density lipoprotein cholesterol, glucose, triglycerides, tumor necrosis factor (TNF) α, soluble TNF receptors 1 and 2, C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist were measured in 233 incident endometrial cancer cases and 446 matched controls. Factor analysis identified 3 components associated with postmenopausal endometrial cancer risk that could be labeled “insulin resistance/metabolic syndrome,” “steroids,” and “inflammation” factors. A fourth component, “lipids,” was not significantly associated with endometrial cancer. In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
- Full Text
- View/download PDF
7. Association of Type 2 Diabetes Susceptibility Variants With Advanced Prostate Cancer Risk in the Breast and Prostate Cancer Cohort Consortium.
- Author
-
Machiela, Mitchell J., Lindström, Sara, Allen, Naomi E., Haiman, Christopher A., Albanes, Demetrius, Barricade, Aurelio, Berndt, Sonja I., Bueno-De-Mesquita, H. Bas, Chanock, Stephen, Gaziano, J. Michael, Gapstur, Susan M., Giovannucci, Edward, Henderson, Brian E., Jacobs, Eric J., Kolonel, Laurence N., Krogh, Vittorio, Jing Ma, Stampfer, Meir J., Stevens, Victoria L., and Stram, Daniel O.
- Subjects
TYPE 2 diabetes risk factors ,PROSTATE tumors ,CONFIDENCE intervals ,STATISTICAL correlation ,DATABASES ,DISEASE susceptibility ,EPIDEMIOLOGY ,GENETIC polymorphisms ,MEDICAL information storage & retrieval systems ,RESEARCH funding ,GENETIC markers ,LOGISTIC regression analysis ,GENOMICS ,DATA analysis ,CONTROL groups ,GENETICS - Abstract
Observational studies have found an inverse association between type 2 diabetes (T2D) and prostate cancer (PCa), and genome-wide association studies have found common variants near 3 loci associated with both diseases. The authors examined whether a genetic background that favors T2D is associated with risk of advanced PCa. Data from the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium, a genome-wide association study of 2,782 advanced PCa cases and 4,458 controls, were used to evaluate whether individual single nucleotide polymorphisms or aggregations of these 36 T2D susceptibility loci are associated with PCa. Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNRIB, FTO, and HNFIB) were nominally associated with PCa (P< 0.05); the association for single nucleotide polymorphism rs757210 at the HNFIB locus was significant when multiple comparisons were accounted for (adjusted P= 0.001). Genetic risk scores weighted by the T2D log odds ratio and multilocus kernel tests also indicated a significant relation between T2D variants and PCa risk. A mediation analysis of 9,065 PCa cases and 9,526 controls failed to produce evidence that diabetes mediates the association of the HNF1B locus with PCa risk. These data suggest a shared genetic component between T2D and PCa and add to the evidence for an interrelation between these diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
8. Interactions Between Genome-wide Significant Genetic Variants and Circulating Concentrations of Insulin-like Growth Factor 1, Sex Hormones, and Binding Proteins in Relation to Prostate Cancer Risk in the National Cancer Institute Breast and Prostate ...
- Author
-
Tsilidis, Konstantinos K., Travis, Ruth C., Appleby, Paul N., Allen, Naomi E., Lindstrom, Sara, Schumacher, Fredrick R., Cox, David, Hsing, Ann W., Ma, Jing, Severi, Gianluca, Albanes, Demetrius, Virtamo, Jarmo, Boeing, Heiner, Bueno-de-Mesquita, H. Bas, Johansson, Mattias, Quirós, J. Ramón, Riboli, Elio, Siddiq, Afshan, Tjønneland, Anne, and Trichopoulos, Dimitrios
- Subjects
PROSTATE tumors ,HYPOTHESIS ,ALLELES ,BLOOD testing ,CANCER patients ,CARRIER proteins ,CONFIDENCE intervals ,CONSORTIA ,STATISTICAL correlation ,REPORTING of diseases ,EPIDEMIOLOGY ,GENETIC polymorphisms ,GENETIC research ,GROWTH factors ,SEX hormones ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,LOGISTIC regression analysis ,DATA analysis ,CONNECTIVE tissue growth factor ,DESCRIPTIVE statistics ,TUMOR risk factors - Abstract
Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) associated with prostate cancer risk. There is limited information on the mechanistic basis of these associations, particularly about whether they interact with circulating concentrations of growth factors and sex hormones, which may be important in prostate cancer etiology. Using conditional logistic regression, the authors compared per-allele odds ratios for prostate cancer for 39 GWAS-identified SNPs across thirds (tertile groups) of circulating concentrations of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), testosterone, androstenedione, androstanediol glucuronide, estradiol, and sex hormone-binding globulin (SHBG) for 3,043 cases and 3,478 controls in the Breast and Prostate Cancer Cohort Consortium. After allowing for multiple testing, none of the SNPs examined were significantly associated with growth factor or hormone concentrations, and the SNP-prostate cancer associations did not differ by these concentrations, although 4 interactions were marginally significant (MSMB-rs10993994 with androstenedione (uncorrected P = 0.008); CTBP2-rs4962416 with IGFBP-3 (uncorrected P = 0.003); 11q13.2-rs12418451 with IGF-1 (uncorrected P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)). The authors found no strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of IGF-1, sex hormones, or their major binding proteins. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
9. Menopausal Hormone Therapy and Risk of Endometrial Carcinoma Among Postmenopausal Women in the European Prospective Investigation into Cancer and Nutrition.
- Author
-
Allen, Naomi E., Tsilidis, Konstantinos K., Key, Timothy J., Dossus, Laure, Kaaks, Rudolf, Lund, Eiliv, Bakken, Kjersti, Gavrilyuk, Oxana, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Fournier, Agnès, Fabre, Alban, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Sacerdote, Carlotta, Krogh, Vittorio, Bendinelli, Benedetta, Tumino, Rosario, and Panico, Salvatore
- Subjects
- *
ESTROGEN replacement therapy , *THERAPEUTIC use of progestational hormones , *AGE distribution , *ANALYSIS of variance , *CANCER , *CHI-squared test , *COMPARATIVE studies , *CONFIDENCE intervals , *STATISTICAL correlation , *REPORTING of diseases , *ENDOMETRIAL cancer , *HORMONE therapy , *LEANNESS , *LONGITUDINAL method , *QUESTIONNAIRES , *REGRESSION analysis , *SMOKING , *SECONDARY analysis , *CONTROL groups , *DISEASE incidence , *PROPORTIONAL hazards models , *POSTMENOPAUSE - Abstract
Estrogen-only menopausal hormone therapy (HT) increases the risk of endometrial cancer, but less is known about the association with other types of HT. Using Cox proportional hazards regression, the authors examined the association of various types of HT with the risk of endometrial cancer among 115,474 postmenopausal women recruited into the European Prospective Investigation into Cancer and Nutrition between 1992 and 2000. After a mean follow-up period of 9 years, 601 incident cases of endometrial cancer were identified. In comparison with never users of HT, risk of endometrial cancer was increased among current users of estrogen-only HT (hazard ratio (HR) = 2.52, 95% confidence interval (CI): 1.77, 3.57), tibolone (HR = 2.96, 95% CI: 1.67, 5.26), and, to a lesser extent, estrogen-plus-progestin HT (HR = 1.41, 95% CI: 1.08, 1.83), although risks differed according to regimen and type of progestin constituent. The association of HT use with risk was stronger among women who were older, leaner, or had ever smoked cigarettes. The finding of a strong increased risk of endometrial cancer with estrogen-only HT and a weaker association with combined HT supports the hypothesis that progestins have an attenuating effect on endometrial cancer risk. The increased risk associated with tibolone use requires further investigation. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
- Full Text
- View/download PDF
10. Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition.
- Author
-
Duell, Eric J., Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, M. C., Clavel-Chapelon, F., Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Tsilidis, Konstantinos K., and Bueno-de-Mesquita, H. Bas
- Subjects
HYPOTHESIS ,ANALYSIS of variance ,CONFIDENCE intervals ,HORMONE therapy ,LONGITUDINAL method ,MEDICAL cooperation ,MENSTRUAL cycle ,OVARIECTOMY ,RESEARCH ,STATISTICAL hypothesis testing ,STATISTICS ,STOMACH tumors ,WOMEN ,DATA analysis ,PROPORTIONAL hazards models ,CASE-control method ,REPRODUCTIVE history - Abstract
The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35–70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; Ptrend = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
- Full Text
- View/download PDF
11. Physical activity and fracture risk: a prospective study of 1898 incident fractures among 34,696 British men and women.
- Author
-
Appleby, Paul N, Allen, Naomi E, Roddam, Andrew W, and Key, Timothy J
- Subjects
- *
AGING , *COMPARATIVE studies , *CONFIDENCE intervals , *BONE fractures , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *MENOPAUSE , *MOTOR ability , *RESEARCH , *RESEARCH funding , *WHITE people , *EVALUATION research - Abstract
Regular physical activity is believed to have a beneficial effect on bone health but may also increase the risk of fractures by increasing the incidence of injury. We examined the association between physical activity and fracture risk in a prospective study of self-reported incident fractures among 34 696 men and women aged 20 to 89 years in the United Kingdom. Over an average of 5.2 years of follow-up, 343 men and 1555 women reported one or more fractures. For the 72% of fractures caused by a fall, the only significant association with physical activity was the lower fracture rate among women with a standing occupation compared with women in sedentary or no employment [incidence rate ratio, 0.81 (95% CI, 0.69-0.95)]. There was a strong positive association between bicycling and fracture risk: P < 0.001 for trend for both sexes. Regular participation in exercise and sports other than walking and bicycling was also associated with an increased fracture risk, and fracture rates were significantly higher for male manual workers compared with men in sedentary or no employment. These positive associations of physical activity with fracture risk applied primarily to fractures not caused by a fall. The relatively low fracture risk among women with a standing occupation might be the result of a beneficial effect of weight-bearing exercise. The markedly increased risk of fractures associated with bicycling, and the moderately increased risk associated with other exercise and sports, are probably the result of an increased incidence of injury. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
12. Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians.
- Author
-
Crowe, Francesca L., Appleby, Paul N., Allen, Naomi E., and Key, Timothy J.
- Subjects
DIETARY fiber ,DIVERTICULUM ,ANALYSIS of variance ,CONFIDENCE intervals ,LONGITUDINAL method ,PROBABILITY theory ,RESEARCH funding ,VEGETARIANISM ,RELATIVE medical risk ,DISEASE risk factors - Abstract
The article presents a prospective cohort study on association between diet and risk of diverticular disease, conducted on British vegetarians and non-vegetarians in Oxford, England. It reveals that vegetarians with a high intake of dietary fibre are less prone to hospitalization and death from diverticular disease. As stated, vegetarians have a 31 percent lower risk compared to meat eaters after accounting for factors like smoking and body mass index.
- Published
- 2011
13. Alcohol drinking and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- Author
-
Fedirko, Veronika, Jenab, Mazda, Rinaldi, Sabina, Biessy, Carine, Allen, Naomi E., Dossus, Laure, Onland-Moret, N. Charlotte, Schütze, Madlen, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Clavel-Chapelon, Françoise, Chabbert-Buffet, Nathalie, Kaaks, Rudolf, Lukanova, Annekatrin, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Oustoglou, Erifili, and Barbitsioti, Antonia
- Subjects
- *
ALCOHOL drinking & health , *ENDOMETRIAL cancer , *LONGITUDINAL method , *NUTRITION , *SEX hormones , *EPIDEMIOLOGY , *CONFIDENCE intervals , *LIFESTYLE Assessment Questionnaire - Abstract
Abstract: Purpose: Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study. Methods: From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. Results: The multivariable HRs (and 95% CIs) compared with light drinkers (0.1–6 g/d) were 1.03 (0.88–1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86–1.17) for 6.1–12 g/d, 1.03 (0.87–1.22) for 12.1–24 g/d, 1.07 (0.87–1.38) for 24.1–36 g/d, and 0.85 (0.61–1.18) for more than 36 g/d (p trend = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98–1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk. Conclusions: Our findings suggest no association between alcohol intake and endometrial cancer risk. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.