1. Increasing Povidone-Iodine Exposure in Endothelial Keratoplasty Tissue Processing and Fungal Infection Impact.
- Author
-
Salisbury CD, Kirk CN, Lee WB, Hamilton SM, Kozarsky AM, Meinecke E, and Stulting RD
- Subjects
- Eye Infections, Bacterial prevention & control, Humans, Postoperative Complications prevention & control, Anti-Infective Agents, Local administration & dosage, Corneal Transplantation methods, Eye Infections, Fungal prevention & control, Povidone-Iodine administration & dosage, Tissue and Organ Harvesting methods
- Abstract
Purpose: To evaluate the effect on donor rim cultures and postoperative infections of doubling the povidone-iodine exposure time during corneal tissue recovery before its use in keratoplasty., Methods: Consecutive donor cornea recoveries were evaluated for positive donor corneal rim cultures and postoperative infections before and after a protocol change of doubling the exposure time of povidone-iodine during donor preparation., Results: In 631 consecutive cornea donor recoveries, 18 (2.9%) had positive fungal rim cultures and 41 (6.5%) had positive bacterial rim cultures. Three (0.48%) developed postoperative fungal infections, and no bacterial infections occurred. After doubling the povidone-iodine exposure time during the recovery process, 725 consecutive corneas were reviewed. Four (0.6%) had positive fungal rim cultures, and 29 (4.0%) had positive bacterial rim cultures. No postoperative fungal or bacterial infections occurred. No noticeable increase in epithelial toxicity developed between the 2 groups., Conclusions: Increasing the povidone-iodine exposure time during the donor cornea recovery process decreased the rate of positive donor corneal rim fungal cultures (P = 0.001), positive donor corneal rim bacterial cultures (P = 0.04), and postoperative fungal infections (P = 0.06).
- Published
- 2019
- Full Text
- View/download PDF