1. The Association Between Antibody Responses and Prolonged Viable Severe Acute Respiratory Syndrome Coronavirus 2 Shedding in Immunocompromised Patients: A Prospective Cohort Study.
- Author
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Lim SY, Kim JW, Kim JY, Kang SW, Jang CY, Chang E, Yang JS, Kim KC, Jang HC, Kim DS, Shin Y, Lee JY, and Kim SH
- Subjects
- Humans, Male, Prospective Studies, Female, Middle Aged, Aged, RNA, Viral, Adult, Antibody Formation immunology, Virus Shedding, Immunocompromised Host, COVID-19 immunology, COVID-19 virology, SARS-CoV-2 immunology, Antibodies, Viral blood, Antibodies, Viral immunology, Antibodies, Neutralizing blood, Antibodies, Neutralizing immunology, Immunoglobulin G blood, Immunoglobulin G immunology
- Abstract
Immunocompromised patients with coronavirus disease 2019 were prospectively enrolled from March to November 2022 to understand the association between antibody responses and severe acute respiratory syndrome coronavirus 2 shedding. A total of 62 patients were analyzed, and the results indicated a faster decline in genomic and subgenomic viral RNA in patients with higher neutralizing and S1-specific immunoglobulin G (IgG) antibodies (both P < .001). Notably, high neutralizing antibody levels were associated with a significantly faster decrease in viable virus cultures (P = .04). Our observations suggest the role of neutralizing antibodies in prolonged virus shedding in immunocompromised patients, highlighting the potential benefits of enhancing their humoral immune response through vaccination or monoclonal antibody treatments., Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
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