1. Injectable Ovalbumin-Based Composite Implant for Photothermal Tumor Therapy.
- Author
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Zhang J, An X, Zheng Y, Chen Y, Wu C, and Wang S
- Subjects
- Animals, Antibiotics, Antineoplastic administration & dosage, Cell Line, Cell Proliferation drug effects, Cell Survival drug effects, Doxorubicin administration & dosage, Drug Carriers administration & dosage, Drug Carriers chemistry, Drug Screening Assays, Antitumor, Humans, Indoles administration & dosage, Infrared Rays, Iohexol administration & dosage, Mice, Mice, Inbred Strains, Neoplasms, Experimental diagnostic imaging, Neoplasms, Experimental drug therapy, Optical Imaging, Ovalbumin administration & dosage, Photosensitizing Agents administration & dosage, Polymers administration & dosage, Tumor Microenvironment drug effects, Antibiotics, Antineoplastic pharmacology, Doxorubicin pharmacology, Hyperthermia, Induced, Indoles pharmacology, Iohexol pharmacology, Ovalbumin chemistry, Photosensitizing Agents pharmacology, Photothermal Therapy, Polymers pharmacology
- Abstract
Polymeric hydrogels with three-dimensional network structures have found tremendous applications in biomedicine. Herein, we report the synthesis of a multifunctional implant based on ovalbumin (OVA) as a carrier capable of synergistically delivering a photothermal transducing agent (polydopamine, PDA) to tumors. The formation of PDA was achieved by utilizing the basicity of OVA, whereas the formation of the hydrogel implant was achieved through the in vitro/in vivo near-infrared (NIR) laser-induced hyperthermia of PDA. The as-prepared PDA@OVA implant exhibits high photothermal conversion efficiency (38.7 %). Once implanted in vivo, the OVA-based implant shows great versatility in the treatment of malignant tumors. Furthermore, a chemotherapeutic (doxorubicin, DOX) and a contrast agent (iohexol), dispersed in the OVA solution in advance, can also be firmly entrapped in the hydrogel along with the hydrogel formation. It is anticipated that the multifunctional OVA-based implant, not showing any obvious toxicity to healthy tissue, could be a promising system for synergistic cancer treatment., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2020
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