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A cascade reaction of 2‐alkynylbenzaldehydes and 2‐(4,5‐diphenyl‐1H‐imidazol‐2‐yl)aniline was treated in DMF catalyzed by AgOTf leading to 6,13,14‐triaryl‐11bH‐imidazo[1,2‐c] isoquinolino[2,1‐a]quinazolines in high yields. This Domino reaction included condensation, cyclization, and acetylenic hydroamination under mild conditions to build fused pentacyclic heterocycle with three new bonds and two new rings. [ABSTRACT FROM AUTHOR]

The benzo[4,5]imidazo[1,2-a]naphthyridines and benzo[4,5]imidazo[2,1-a]isoq-uino lines were obtained via a one-pot domino reaction of 2-(2-bromophenyl)-1H-benzo[d]imidazoles and cyclic 1,3-dicarbonyl compounds in good yields. This copper-catalyzed procedure provided an efficient method for the synthesis of fused pentacyclic heterocycles containing a α-arylation of carbonyl reaction. [ABSTRACT FROM AUTHOR]

Using 2-(2-aminophenyl)quinazolin-4(3 H)-one and 2-(2-phenylethynyl)benzaldehyde as the reactants, silver triflate (AgOTf) was proved to be an efficient catalyst to promote not only quinazoline cyclization, but also the intramolecular hydroamination of alkyne for the synthesis of 6-aryl-17 H ,18a H -isoquinolino[2,1- a ]quinazolino[3,2- c ]quinazolin-17-one derivatives in high yields. [ABSTRACT FROM AUTHOR]

The α‐arylation between cyanoacetate and 2‐(2‐bromophenyl)‐1H‐perimidine took place first catalyzed by CuI/L‐proline in the presence of NaHCO3, and then the amino on perimidine chemoselectively attacked the cyano group to undergo a nucleophilic addition, giving a series of 13‐aminoisoquinolino[2,1‐a]perimidine‐12‐carboxylate derivatives in good yields. [ABSTRACT FROM AUTHOR]

The Sonogashira reaction first, and then intra-molecular hydroamination of alkyne catalyzed by CuI/ o -phen was proved to be an efficient method for the synthesis of imidazo[2,1- a ]isoquinoline, phenanthro[9′,10′:4,5]imidazo[2,1- a ]isoquinoline and acenaphtho[1′,2′:4,5]imidazo [2,1- a ]isoquinoline derivatives in the presence of Cs 2 CO 3 . [ABSTRACT FROM AUTHOR]

The benzyl position was found to be automatically oxidized by oxygen in the reaction of 2-(2-bromophenyl)-1 H -imidazole and 1,3-dicarbonyl compounds catalyzed CuI. This domino procedure involved the subsequent α -arylation, deacylation, nucleophilic addition and benzyl automatic oxidation, and provided an efficient method for the synthesis of (benzo)imidazo[2,1- a isoquinolinone derivatives in good yields. The benzyl position was found to be automatically oxidized by oxygen in the reaction of 2-(2-bromophenyl)-1 H -imidazole and 1,3-dicarbonyl compounds catalyzed CuI. This domino procedure involved the subsequent α -arylation, deacylation, nucleophilic addition and benzyl automatic oxidation, and provided an efficient method for the synthesis of (benzo)imidazo[2,1- a isoquinolinone derivatives in good yields. Image 1 • It is an a -arylation and deacylation promoted by a catalyst of CuI without additional ligand. • The benzyl position was found to be automatically oxidized by oxygen. • It is an efficient method to build imidazo[2,1-a]isoquinolinones in good yields. [ABSTRACT FROM AUTHOR]