1. In the borderland of multifocal motor neuropathy and chronic inflammatory demyelinating polyradiculopathy
- Author
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Ioana-Cristina Ciovica-Oel, Johannes Trenkler, Raffi Topakian, and Petra Müller
- Subjects
medicine.medical_specialty ,Pathology ,Neurology ,Nerve root ,Neural Conduction ,Mismatch negativity ,Dermatology ,behavioral disciplines and activities ,Polyneuropathies ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Peripheral Nerves ,030212 general & internal medicine ,Polyradiculopathy ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Overlap syndrome ,General Medicine ,medicine.disease ,Psychiatry and Mental health ,Polyradiculoneuropathy, Chronic Inflammatory Demyelinating ,Neurology (clinical) ,Differential diagnosis ,business ,psychological phenomena and processes ,030217 neurology & neurosurgery ,Multifocal motor neuropathy - Abstract
Chronic inflammatory demyelinating polyradiculopathy (CIDP) and multifocal motor neuropathy (MMN) are seen as distinct entities with marked differences in pathophysiology and clinical, laboratory, and imaging features. We report a patient with an immune-mediated neuropathy in the borderland of CIDP and MMN, whose magnetic resonance imaging and cerebrospinal fluid (CSF) features strongly resembled CIDP, while the clinical course and treatment response suggested the diagnosis of MMN without conduction blocks. There is strong evidence that MMN is not a variant of CIDP and that these conditions can be separated pathologically. Our case report widens the spectrum of MMN presentations, indicating the existence of a clinical overlap syndrome of MMN and CIDP, and emphasizing the need for more precise criteria regarding CSF and nerve root imaging abnormalities in the differentiation of chronic immune-mediated neuropathies.
- Published
- 2020