1. Parkinson’s disease pathogenesis from the viewpoint of small fish models
- Author
-
Hideaki Matsui and Ryosuke Takahashi
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Neurology ,Parkinson's disease ,Oryzias ,Disease ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Parkinsonian Disorders ,Lysosome ,medicine ,Animals ,Humans ,Zebrafish ,Biological Psychiatry ,biology ,Dopaminergic Neurons ,Dopaminergic ,Parkinson Disease ,biology.organism_classification ,medicine.disease ,Mitochondria ,Disease Models, Animal ,Psychiatry and Mental health ,030104 developmental biology ,medicine.anatomical_structure ,%22">Fish ,Neurology (clinical) ,Lysosomes ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Parkinson's disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a new model for Parkinson disease. In this review, we summarize fish models of Parkinson's disease mainly using our own findings and explain two major hypotheses of PD: lysosome dysfunction theory and mitochondrial dysfunction theory. Finally, we discuss the potential for future application of small fish model.
- Published
- 2017