1. Effect of beta-endorphin C-terminal peptides on glucose uptake in isolated skeletal muscles of the mouse.
- Author
-
Evans A and Smith ME
- Subjects
- Animals, Biological Transport drug effects, Deoxyglucose metabolism, Dipeptides pharmacology, Female, In Vitro Techniques, Insulin pharmacology, Male, Mice, Mice, Inbred C57BL, Muscle, Skeletal metabolism, beta-Endorphin pharmacology, Glucose metabolism, Muscle, Skeletal drug effects, Peptide Fragments pharmacology, beta-Endorphin analogs & derivatives
- Abstract
The uptake of a nonmetabolizable derivative of glucose, [3H]2-deoxy-D-glucose was examined in isolated slow (soleus) and fast (extensor digitorum longus, EDL) muscles of adult mice. An analogue of beta-endorphin (28-31), Ac-Lys-D-Lys-Sar-Glu, which is stable to proteolytic digestion, enhanced the uptake of glucose into the slow and fast muscles. The muscles of male mice were more sensitive to the peptide than those of female mice. The maximum uptake seen in the presence of the peptide was similar to that seen with insulin in the soleus muscle and greater than that seen with insulin in the EDL muscle.
- Published
- 1997
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