16 results on '"Zhang, Xing-Jie"'
Search Results
2. Toonaolides A-X, limonoids from Toona ciliata: Isolation, structural elucidation, and bioactivity against NLRP3 inflammasome.
- Author
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Shi QQ, Zhang XJ, Zhang Y, Wang Q, Amin M, Li Q, Wu XW, Li XL, Zhang RH, Dai XC, and Xiao WL
- Subjects
- Density Functional Theory, Dose-Response Relationship, Drug, Humans, Inflammasomes metabolism, Limonins chemistry, Limonins isolation & purification, Molecular Structure, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Plant Extracts chemistry, Plant Extracts isolation & purification, Structure-Activity Relationship, Inflammasomes antagonists & inhibitors, Limonins pharmacology, NLR Family, Pyrin Domain-Containing 3 Protein antagonists & inhibitors, Plant Extracts pharmacology, Toona chemistry
- Abstract
Twenty-four new limonoids, toonaolides A-X (1-24), characterized with an α,β-unsaturated-γ-lactone A-ring were isolated from the twigs of Toona ciliata. Their structures and absolute configurations were elucidated by spectroscopic data, X-ray diffraction crystallography, and quantum chemistry calculations. Most of the isolated compounds (except 9, 18, and 24 which possessed the maleimide ring) featured the rare 21-hydroxybutenolide or 23-hydroxybutenolide moieties. In particular, compound 1 has an unprecedented limonoid architecture with 6/6 cis-fused A/B ring system and 2 has an unusual tetrahydrofuran ring B skeleton, featuring a 7/5/6/5 ring system. The biological evaluation showed that compounds 9, 11, 12, 14, and 18 exhibited significantly anti-NLRP3 inflammasome activity with IC
50 values ranging from 3.2 to 9.7 μM. Analysis of IL-1β and caspase-1 expression revealed that compounds 11 and 12 are selective inhibitors of NLRP3 inflammasome, which could ameliorate cell pyroptosis by blocking NLRP3 inflammasome activation., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2020
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3. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana.
- Author
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Wang Y, Lin J, Wang Q, Shang K, Pu DB, Zhang RH, Li XL, Dai XC, Zhang XJ, and Xiao WL
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- Animals, Anti-Inflammatory Agents isolation & purification, Cell Line, China, Diterpenes, Clerodane isolation & purification, Lipopolysaccharides metabolism, Magnetic Resonance Spectroscopy, Mice, Molecular Structure, Nitric Oxide metabolism, Phytochemicals isolation & purification, Plant Leaves chemistry, Plant Stems chemistry, Anti-Inflammatory Agents pharmacology, Callicarpa chemistry, Diterpenes, Clerodane pharmacology, Phytochemicals pharmacology, Plant Extracts chemistry
- Abstract
Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F (1-6), together with seven analogues (7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells., (Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
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4. Benzophenone glycosides and epicatechin derivatives from Malania oleifera.
- Author
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Wu XD, Cheng JT, He J, Zhang XJ, Dong LB, Gong X, Song LD, Zheng YT, Peng LY, and Zhao QS
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- Anti-HIV Agents chemistry, Anti-HIV Agents pharmacology, Benzophenones chemistry, Benzophenones pharmacology, Catechin chemistry, Catechin isolation & purification, Catechin pharmacology, Cell Line, Glycosides chemistry, Glycosides pharmacology, Humans, Molecular Structure, Plant Extracts chemistry, Plant Extracts pharmacology, Anti-HIV Agents isolation & purification, Benzophenones isolation & purification, Catechin analogs & derivatives, Glycosides isolation & purification, HIV-1 drug effects, Olacaceae chemistry, Plant Extracts isolation & purification
- Abstract
A new benzophenone C-glycoside, malaferin A (1), and two new epicatechin derivatives, malaferin B (2) and malaferin C (3), together with five known compounds were isolated from Malania oleifera. In addition, (-)-epicatechin-3-O-benzoate (6) was isolated for the first time from a natural resource. Structures of 1-3 were determined on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. All of the compounds were evaluated for anti-HIV activities., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2012
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5. Daphnane-type diterpene esters with cytotoxic and anti-HIV-1 activities from Daphne acutiloba Rehd.
- Author
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Huang SZ, Zhang XJ, Li XY, Kong LM, Jiang HZ, Ma QY, Liu YQ, Hu JM, Zheng YT, Li Y, Zhou J, and Zhao YX
- Subjects
- Anti-HIV Agents chemistry, Anti-HIV Agents isolation & purification, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Cell Line, Tumor, Cell Proliferation drug effects, Diterpenes chemistry, Diterpenes isolation & purification, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Esters chemistry, Esters isolation & purification, HL-60 Cells, Humans, Molecular Conformation, Plant Extracts chemistry, Plant Extracts isolation & purification, Stereoisomerism, Structure-Activity Relationship, Anti-HIV Agents pharmacology, Antineoplastic Agents pharmacology, Daphne chemistry, Diterpenes pharmacology, Esters pharmacology, HIV-1 drug effects, Plant Extracts pharmacology
- Abstract
Seven previously unreported daphnane-type diterpene esters named acutilobins A-G, together with 12 known ones, were isolated from EtOAc extract of Daphne acutiloba Rehd. Their structures were elucidated based on the spectroscopic data. The cytotoxic and anti-HIV-1 activities of these daphnane-type diterpene esters were evaluated through bioassays. Fourteen of these isolates exhibited definite cytotoxic activities against the five human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480. Additionally, anti-HIV-1 activities were observed in 13 daphnane-type diterpene esters, among which acutilobins A-G exhibited significant anti-HIV-1 activities with EC₅₀ below 1.5 nM and SI over 10,000. Particularly, genkwanineVIII showed the strongest activity with EC₅₀ 0.17 nM and SI 187,010., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2012
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6. Phenols with anti-HIV activity from Daphne acutiloba.
- Author
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Huang SZ, Zhang XJ, Li XY, Jiang HZ, Ma QY, Wang PC, Liu YQ, Hu JM, Zheng YT, Zhou J, and Zhao YX
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- Anti-Retroviral Agents isolation & purification, Caffeic Acids isolation & purification, Molecular Structure, Plant Extracts chemistry, Anti-Retroviral Agents pharmacology, Caffeic Acids pharmacology, Daphne chemistry, HIV-1 drug effects, Lignans isolation & purification, Lignans pharmacology, Plant Extracts pharmacology
- Abstract
The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2DNMR spectroscopy aswell as HR‑ESI‑MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIVactivity with EC(50) values of 0.39 and 0.16 μg/mL, respectively., (© Georg Thieme Verlag KG Stuttgart · New York.)
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- 2012
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7. Two new oleanane triterpenes from Maytenus hookeri.
- Author
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Yang, Quan-Yu, Yang, Song-Xue, Wei, Qiong, Ma, Yan-Zi, Li, Bo, Wu, Xue-Wen, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie
- Subjects
TRITERPENES ,ANTI-inflammatory agents ,IN vitro studies ,HIGH performance liquid chromatography ,RESEARCH funding ,NUCLEAR magnetic resonance spectroscopy ,COLORIMETRY ,PLANT stems ,CELL proliferation ,PHYTOCHEMICALS ,LACTATE dehydrogenase ,ANALYTICAL biochemistry ,PLANT extracts ,CELL lines ,CELL culture ,MEDICINAL plants ,MOLECULAR structure ,SPECTRUM analysis ,COLLECTION & preservation of biological specimens ,CELL survival ,SIGNAL peptides ,SPECTROPHOTOMETRY - Abstract
Two new triterpenes mayteneri A (1), mayteneri B (2), and seven known compounds (3-9) were isolated from stems of Maytenus hookeri Loes. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds 3-9 were determined by comparison of their spectral with those reported. Compounds 4-7 showed significant inhibitory activity for NLRP3 inflammasome, with the IC
50 values of 2.36–3.44 μM. [ABSTRACT FROM AUTHOR]- Published
- 2024
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8. Two new compounds from Verbena bonariensis.
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Li, Rui, Chen, Yuan-Si, Bi, De-Wen, Wei, Qiong, Zhou, Ya-Ling, Qiu, Xiong, Zhang, Rui-Han, Zhang, Xing-Jie, Xiao, Wei-Lie, Li, Hong-Liang, and Li, Xiao-Li
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THERAPEUTIC use of antineoplastic agents ,IN vitro studies ,MEDICINAL plants ,HETEROCYCLIC compounds ,NUCLEAR magnetic resonance spectroscopy ,ANTINEOPLASTIC agents ,COMPARATIVE studies ,LEAVES ,RESEARCH funding ,PLANT extracts ,TUMORS ,MOLECULAR structure ,CELL surface antigens ,CELL lines ,PHYTOSTEROLS ,IMMUNODIAGNOSIS ,CHOLECYSTOKININ ,BREAST tumors ,PHARMACODYNAMICS - Abstract
Two new compounds verboncin A (1) and verboncin B (4) and 14 known compounds (2–3 and 5–16) were isolated from Verbena bonariensis, and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the results were compared with literature values. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD). The cytotoxicity of some of the compounds against MCF-7, HCT-116, MDA-MB-231, and SW620 human cancer cell lines were evaluated, in which compound 4 showed negligible cytotoxic activity with an IC
50 value of 68.08 ± 0.35 µM against the MCF-7 cell line. [ABSTRACT FROM AUTHOR]- Published
- 2023
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9. Centrantheroside F, a new ionone glycoside from Centranthera grandiflora.
- Author
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Liang, Xin-Xin, Li, Qi, Li, Hui-Juan, Ning, Yan-Mei, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie
- Subjects
EXPERIMENTAL design ,HIGH performance liquid chromatography ,GLYCOSIDES ,NUCLEAR magnetic resonance spectroscopy ,PLANT roots ,DESCRIPTIVE statistics ,RESEARCH funding ,PLANT extracts ,NITRIC oxide ,MOLECULAR structure ,SPECTRUM analysis - Abstract
One new ionone glycoside, named centrantheroside F (1), together with 9 known compounds (2-10), were isolated from the roots of Centranthera grandiflora. Their structures were determined by spectroscopic data analyses and comparing with the literature data. The absolute configuration of 1 was confirmed via 2 D NMR and electronic circular dichroism (ECD). All isolated compounds were evaluated for their inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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10. Euphzycopins A − D, macrocyclic diterpenoids with potential anti-inflammatory activity from Euphorbia Helioscopia.
- Author
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Qiu, Xiong, Zhang, Yu, Xu, Yao-Jun, Liang, Zhong-Dan, Dai, Xiao-Chang, Xiao, Wei-Lie, Zhang, Xing-Jie, and Li, Xiao-Li
- Subjects
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PROTEINS , *ANTI-inflammatory agents , *HYDROCARBONS , *FLUORESCENT antibody technique , *PLANT extracts - Abstract
Four new diterpenoids (1–4) and four known diterpenoids (5–8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome with an IC 50 value of 7.75 μM. Further, the inhibitory effect of 4 was determined using immunofluorescence assays. [Display omitted] • Four new diterpenoids (1–4) and four known diterpenoids (5 - 8) were purified from the whole plant of Euphorbia helioscopia L. • Compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system • Compound 4 showed strong activity with IC 50 values of 7.75 μM. Frther, the inhibitory effects of 4 on protein levels were determined using immunofluorescence assays. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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11. Bioactive diterpenoids isolated from the twigs and leaves of Casearia velutina.
- Author
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Li, Yan, Li, Jian-Mei, Xu, Yao-Jun, Zu, Xue-Dan, He, Han, Sun, Yan, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie
- Subjects
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MEDICINAL plants , *BIOLOGICAL products , *ANTI-inflammatory agents , *INFLAMMATION , *ORGANIC compounds , *PHYTOCHEMICALS , *PLANT stems , *LEAVES , *MASS spectrometry , *PLANT extracts , *PHARMACODYNAMICS - Abstract
Nine previously undescribed clerodane-type diterpenoids (1–9), named caseabalanspenes A-I , along with six know compounds (10–15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determination of the molecular formula of the compound by high resolution mass spectrometry (HR-ESI-MS). It is worth noting that compound 7 contains N- heterocycle. Compounds 1–8 were tested the anti-inflammasome activity, and compound 3 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC 50 values of 2.90 μM. [Display omitted] • Nine undescribed clerodane diterpenoids were isolated from Casearia velutina. • Their structures were determined by 1D, 2D-NMR and HR-ESI-MS analyses. • The structure of compound 7 contains an N-heterocycle. • Compound 3 exhibited NLRP3-inflammasome inhibitory activity with IC 50 values of 2.90 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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12. 16,17-dinor-abietane diterpenoids from Casearia kurzii.
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Li, Rui, Sun, Xiao-Rong, He, Xiao-Ting, Zhou, Xue-Mei, Wu, Xue-Wen, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie
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INTERLEUKINS , *MEDICINAL plants , *TERPENES , *INFLAMMATION , *ANTI-inflammatory agents , *PLANT anatomy , *NUCLEAR magnetic resonance spectroscopy , *SIGNAL peptides , *MACROPHAGES , *APOPTOSIS , *PHYTOCHEMICALS , *LEAVES , *MASS spectrometry , *DESCRIPTIVE statistics , *PLANT extracts , *MOLECULAR structure , *CASPASES , *PHARMACODYNAMICS - Abstract
Eleven undescribed 16,17-dinor-abietane diterpenoids, caseazins A-K (1 − 11), and ten known diterpenoids (12 − 21) were isolated from the twigs and leaves of Casearia kurzii (Flacourtiaceae). Caseazins A-K were the first abietane -type dinorditerpenoids to have been isolated from the plant of Casearia kurzii. Their chemical structures were elucidated using a combination of 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configurations of 5 and 10 were established by electronic circular dichroism calculations. Moreover, compounds 2 , 3 , 13 , 14 , and 18 exhibited anti-inflammatory activity with IC 50 values of 0.17, 0.36, 6.55, 1.30, and 4.53 μM, respectively. IL-1β and caspase-1 analyses suggested that compound 14 inhibited NLRP3 inflammasome activation and blocked macrophage pyroptosis. Diterpenoids from Casearia kurzii with NLRP3 inflammasome inhibitory activity were reported in this research. [Display omitted] • Eleven undescribed dinorditerpenoids were isolated from Casearia kurzii. • The compound 14 showed potent inhibitory activity against pyroptosis by blocking NLRP3 inflammasome activation. Their structures were established by elucidated by NMR, HRESIMS and ECD analyses. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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13. Caseatardies A-K, eleven undescribed clerodane diterpenoids isolated from Casearia tardieuae and their anti-inflammatory activity.
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Zhang, Jing-Jing, Yang, Peng-Yun, Fu, Quan, Wei, Qiong, Bi, De-Wen, Wu, Xue-Wen, Cheng, Bin, Zhang, Rui-Han, Dai, Xiao-Chang, Zhang, Xing-Jie, Li, Xiao-Li, and Xiao, Wei-Lie
- Subjects
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ANTI-inflammatory agents , *ORGANIC compounds , *NUCLEAR magnetic resonance spectroscopy , *HYDROCARBONS , *PHYTOCHEMICALS , *LEAVES , *MASS spectrometry , *LACTATE dehydrogenase , *PLANT extracts , *LEAD - Abstract
A phytochemical investigation to obtain bioactive substances as lead compounds or agents for anti-inflammatory led to the obtainment of eleven previously undescribed clerodane diterpenoids, named caseatardies A-K (1 − 11), and four known clerodane diterpenoids (12 – 15) from the twigs and leaves of Casearia tardieuae. The structural elucidation of these clerodane diterpenoids was based on 1D and 2D-NMR spectroscopy (COSY, HSQC, HMBC and ROESY) as well as high resolution mass spectrometry (HR-ESI-MS). The relative configurations were defined by ROESY correlations. The anti-inflammatory activity of all the isolated compounds was screened and compound 15 decreased LDH level in a dose-dependent manner, showing IC 50 value of 2.89 μM. [Display omitted] • Eleven new clerodane diterpenoids with conjugated diene side chain at C-9 were isolated from Casearia tardieuae. • The compound 15 showed potent inhibitory activity against pyroptosis by blocking NLRP3 inflammasome activation. • Their structures were established by elucidated by 1D, 2D-NMR and HR-ESI-MS analyses. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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14. Ten new prenylated flavonoids from Macaranga denticulata and their antitumor activities.
- Author
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Huang, Jia-Bi, Chen, Yuan-Si, Wang, Meng-Ru, Li, Rong-Shuai, Zhao, Xue-Rong, Kaunda, Joseph Sakah, Zhang, Rui-Han, Zhang, Xing-Jie, Xiao, Wei-Lie, Li, Hong-Liang, and Li, Xiao-Li
- Subjects
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FLAVONOIDS , *ANTINEOPLASTIC agents , *CELL proliferation , *PLANT extracts , *CELL lines - Abstract
Ten new prenylated flavonoids, named denticulains A-J (1−10), together with seven known prenylated flavonoids (11–17) were isolated from Macaranga denticulata. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison with literature data. In addition, compounds 1 and 14 inhibited the proliferation of SW620 and HCT-116 cell lines with an IC 50 value of 46.08 μM and 56.83 μM, respectively. [Display omitted] • Ten new prenylated flavonoids were isolated from Macaranga denticulata. • Some compounds have week anticancer activities. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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15. Euphzycopias A−I, macrocyclic diterpenes with NLRP3 inflammasome inhibitory activity from Euphorbia helioscopia L.
- Author
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Zhang, Yu, Xiong, Feng, Zhang, Jing-Jing, Yue, Chen-Fang, Bi, De-Wen, Cheng, Bin, Wu, Xue-Wen, Li, Qing, Zhang, Xing-Jie, Zhang, Rui-Han, Dai, Xiao-Chang, Shi, Qiang-Qiang, Xiao, Wei-Lie, and Li, Xiao-Li
- Subjects
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PROTEIN metabolism , *SIGNAL peptides , *PHYTOCHEMICALS , *HYDROCARBONS , *PLANT extracts , *INFLAMMATORY mediators , *CHEMICAL inhibitors - Abstract
A phytochemical investigation was conducted on Euphorbia helioscopia , resulting in the isolation of thirteen compounds, including nine undescribed diterpenoids, Euphzycopias A − I (1 – 9), of which the skeletons of compounds 1 – 4 were found in E. helioscopia L. Compounds 1 – 3 had 5/7/6 cyclic systems, while compound 4 had a 4/11 polycyclic system with a 4,7-cyclic ether between C-4 and C-7. The anti-inflammasome test using the isolated compounds (1–6, 8–13) showed that the diterpenes from E. helioscopia L. had a strong inhibitory effect on NLRP3 inflammasomes with IC 50 values of 3.34–14.92 μM. [Display omitted] • Nine undescribed diterpenoids were isolated from Euphorbia helioscopia L. • The skeletons of the first four compounds first appeared in the genus Euphorbia L. • Some compounds had significant anti-inflammatory activity on NLRP3 inflammasome. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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16. Diterpenoids from Callicarpa rubella and their in vitro anti-NLRP3 inflammasome activity.
- Author
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Li, Qing, Wu, Xue-Wen, Wang, Qi, Sun, Tian-Tian, Shi, Qiang-Qiang, Cheng, Bin, Gong, Shuang, Zhang, Yu, Yue, Chen-Fang, Xiong, Feng, Zhang, Xing-Jie, Zhang, Ruihan, and Xiao, Wei-Lie
- Subjects
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HYDROCARBON analysis , *ANALYSIS of variance , *ANTI-inflammatory agents , *ENZYME-linked immunosorbent assay , *MEDICINAL plants , *NUCLEAR magnetic resonance spectroscopy , *STATISTICS , *PLANT extracts , *DATA analysis , *STATISTICAL significance , *SIGNAL peptides , *IN vitro studies - Abstract
Nine new diterpenoids, Rubellacrns A − I (1–9), including five isopimaranes (1–4, 9), four pimaranes (5–8), together with five known isopimarane analogues (10–14), were isolated from Callicarpa rubella. The structures of these compounds were unambiguously established by HR-ESIMS and NMR spectroscopic data, the absolute configurations of compounds 5 and 9 were determined by ECD. All the isolated compounds were tested for their anti-inflammatory effects and compounds 2 and 11–14 showed NLRP3-inflammasome inhibitory activity with IC 50 values ranging from 7.02 to 14.38 μM. Unlabelled Image • Nine new diterpenoids were isolated from Callicarpa rubella. • The absolute configuration of 5 and 9 was deduced by ECD. • The new compound 2 showed potent inhibition of inflammasome activation. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
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