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51. Antigen-dependent multistep differentiation of T follicular helper cells and its role in SARS-CoV-2 infection and vaccination

Author

Dirk Baumjohann, Nicolas Fazilleau, Benson-Rumiz, Alicia, IMPACT DE LA FORMULATION VACCINALE SUR LA COMPOSITION DES COMPARTMENTS LYMPHOCYTAIRES A MEMOIRE TFH ET B - - MEMO-SIGN2016 - ANR-16-CE15-0002 - AAPG2016 - VALID, Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique - - Ig-MemImpact2016 - ANR-16-CE15-0019 - AAPG2016 - VALID, University of Bonn, University Hospital Bonn, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Société Française d'Immunologie (SFI), ANR-16-CE15-0002,MEMO-SIGN,IMPACT DE LA FORMULATION VACCINALE SUR LA COMPOSITION DES COMPARTMENTS LYMPHOCYTAIRES A MEMOIRE TFH ET B(2016), and ANR-16-CE15-0019,Ig-MemImpact,Rôle de la classe des Ig / BCR dans les interactions cellulaires supportant la mémoire immune et impact immunopathologique(2016)

Subjects
0301 basic medicine, COVID-19 Vaccines, Immunology, T cells, Reviews, Antibody formation, medicine.disease_cause, CXCR5, Autoimmunity, Pathogenesis, memory, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Immune system, antigen, Antigen, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, Immunology and Allergy, Compartment (development), Animals, Humans, Basic, Antigens, Viral, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, biology, SARS-CoV-2, COVID-19, Cell Differentiation, T-Lymphocytes, Helper-Inducer, differentiation, Highlights, 030104 developmental biology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, biology.protein, Review|Basic, Antibody, Immunologic Memory, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030215 immunology
Abstract

T follicular helper (Tfh) cells play an essential role in regulating the GC reaction and, consequently, the generation of high‐affinity antibodies and memory B cells. Therefore, Tfh cells are critical for potent humoral immune responses against various pathogens and their dysregulation has been linked to autoimmunity and cancer. Tfh cell differentiation is a multistep process, in which cognate interactions with different APC types, costimulatory and coinhibitory pathways, as well as cytokines are involved. However, it is still not fully understood how a subset of activated CD4+ T cells begins to express the Tfh cell‐defining chemokine receptor CXCR5 during the early stage of the immune response, how some CXCR5+ pre‐Tfh cells enter the B‐cell follicles and mature further into GC Tfh cells, and how Tfh cells are maintained in the memory compartment. In this review, we discuss recent advances on how antigen and cognate interactions are important for Tfh cell differentiation and long‐term persistence of Tfh cell memory, and how this is relevant to the current understanding of COVID‐19 pathogenesis and the development of potent SARS‐CoV‐2 vaccines., Tfh cell differentiation is a multistep process: Tfh cells first emerge after contact with DCs in the T‐cell zone (step 1), migrate to the T/B border to interact with activated B cells (step 2), and together with continued interactions with B cells seed GCs in follicles (step 3).

Published
2021
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52. Les nouvelles maladies héréditaires du métabolisme du programme français de dépistage néonatal

Author

Isabelle Oliver-Petit, Magali Gorce, Jérôme Ausseil, Guy Touati, Pierre Broué, Benson-Rumiz, Alicia, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut Fédératif de Biologie (IFB)

Subjects
Pediatrics, medicine.medical_specialty, Homocystinuria, Tyrosinemia Type I, General Biochemistry, Genetics and Molecular Biology, MESH: Congenital Bone Marrow Failure Syndromes, medicine, MESH: Lipid Metabolism, Inborn Errors, Carnitine, MESH: Metabolism, Inborn Errors* / epidemiology, MESH: Neonatal Screening, Newborn screening, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Maple syrup urine disease, Glutaric aciduria, MESH: Infant, Newborn, MESH: Muscular Diseases, MESH: Mitochondrial Diseases, General Medicine, Metabolism, medicine.disease, Isovaleric Acidemia, MESH: Acyl-CoA Dehydrogenase, Long-Chain / deficiency, MESH: Metabolism, Inborn Errors* / diagnosis, MESH: Amino Acid Metabolism, Inborn Errors, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug
Abstract

Inborn Errors of Metabolism (IEM) are rare and heterogenous disorders. For most IEMs, clinical signs are non-specific or belated. Late diagnosis is frequent, leading to death or severe sequelae. Some IEM induce intermediate metabolites circulating in the blood. They may be detected by tandem mass spectrometry. This method allows the simultaneous detection of many IEM in different metabolic pathways. In France, newborn screening (NBS) program for IEM, limited to phenylketonuria for decades, has been recently extended to medium chain acyl-CoA dehydrogenase deficiency. Rationale, methodology and organization of this new NBS program are described. Seven other IEM (maple syrup urine disease, homocystinuria, tyrosinemia type I, glutaric aciduria type I, isovaleric acidemia, long chain hydroxy-acyl-CoA dehydrogenase deficiency, carnitine uptake disorder) should be screened in the next program extension. Efforts are needed to fully understand the predictive value of each abnormal testing at birth, decrease the false positive rate, and develop the adequate management strategies., Les maladies héréditaires du métabolisme (MHM) sont un groupe de maladies rares et cliniquement hétérogènes. Le retard diagnostique est fréquent, conduisant souvent au décès du patient ou à de graves séquelles. Certaines MHM entraînent l’accumulation de métabolites intermédiaires circulant dans le sang, qui sont détectables par une méthode commune utilisant la spectrométrie de masse en tandem. Cette méthode permet la reconnaissance simultanée de plusieurs de ces maladies affectant différentes voies métaboliques. En France, le programme de dépistage néonatal (DNN) des MHM, longtemps limité à la phénylcétonurie, a récemment été étendu au déficit en déshydrogénase des acyl-CoA à chaîne moyenne (MCADD). Le rationnel, la méthode et l’organisation de ce nouveau DNN sont décrits dans cet article. Sept nouvelles MHM (leucinose, homocystinurie, tyrosinémie de type I, acidurie glutarique de type I, acidurie isovalérique, déficit en déshydrogénase des hydroxy-acyl-CoA à chaîne longue, déficit du transporteur de la carnitine) devraient être dépistées, grâce à une prochaine extension du programme de DNN. Des efforts sont nécessaires pour mieux comprendre et prévoir la signification de chaque test anormal à la naissance, diminuer les taux de faux positifs, et développer les stratégies de prise en charge adéquates.

Published
2021
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53. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases

Author

Anton Kamnev, Nicole Boucheron, Christian Seiser, Ci Zhu, Patricia Hamminger, Elisa Kaba, Johannes B. Huppa, Wilfried Ellmeier, Loïc Dupré, Christoph Bock, Ramona Rica, Teresa Preglej, Michael Trauner, Ruth Lyck, Marlis Alteneder, René Platzer, Britta Engelhardt, Darina Waltenberger, Valentina Stolz, Luca Marchetti, Jan Bauer, Lisa Sandner, Medizinische Universität Wien = Medical University of Vienna, University of Bern, Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), Research Center for Molecular Medicine of the Austrian Academy of Sciences [Vienna, Austria] (CeMM ), Austrian Academy of Sciences (OeAW), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Project: 675619,H2020,H2020-MSCA-ITN-2015,BtRAIN(2015), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Benson-Rumiz, Alicia, and Brain barriers training - BtRAIN - - H20202015-09-01 - 2019-08-31 - 675619 - VALID

Subjects
0301 basic medicine, T cell, Immunology, 610 Medicine & health, CD18, Adoptive CD4+ T cell transfer colitis, T cell migration, 03 medical and health sciences, 0302 clinical medicine, Histone deacetylases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, Immunology and Allergy, 030203 arthritis & rheumatology, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Experimental autoimmune encephalomyelitis, biology, Chemistry, CD44, medicine.disease, Acquired immune system, Intestinal epithelium, Leukocyte extravasation, Cell biology, 030104 developmental biology, medicine.anatomical_structure, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, biology.protein, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; CD4+ T cell trafficking is a fundamental property of adaptive immunity. In this study, we uncover a novel role for histone deacetylase 1 (HDAC1) in controlling effector CD4+ T cell migration, thereby providing mechanistic insight into why a T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis (EAE). HDAC1-deficient CD4+ T cells downregulated genes associated with leukocyte extravasation. In vitro, HDAC1-deficient CD4+ T cells displayed aberrant morphology and migration on surfaces coated with integrin LFA-1 ligand ICAM-1 and showed an impaired ability to arrest on and to migrate across a monolayer of primary mouse brain microvascular endothelial cells under physiological flow. Moreover, HDAC1 deficiency reduced homing of CD4+ T cells into the intestinal epithelium and lamina propria preventing weight-loss, crypt damage and intestinal inflammation in adoptive CD4+ T cell transfer colitis. This correlated with reduced expression levels of LFA-1 integrin chains CD11a and CD18 as well as of selectin ligands CD43, CD44 and CD162 on transferred circulating HDAC1-deficient CD4+ T cells. Our data reveal that HDAC1 controls T cell-mediated autoimmunity via the regulation of CD4+ T cell trafficking into the CNS and intestinal tissues.

Published
2021
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54. Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

Author

Emmanuel Bujold, Paul Guerby, Robert Salvayre, Audrey Swiader, Anne Nègre-Salvayre, Christophe Vayssière, Frédéric Pont, Olivier Parant, Oriane Tasta, Benson-Rumiz, Alicia, Institut des Maladies Métaboliques et Casdiovasculaires (UPS/Inserm U1297 - I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche du CHU de Québec-Université Laval (CRCHUQ), CHU de Québec–Université Laval, and Université Laval [Québec] (ULaval)-Université Laval [Québec] (ULaval)

Subjects
0301 basic medicine, Placenta, Clinical Biochemistry, S-glutathionylation, Review Article, medicine.disease_cause, Biochemistry, Lipid peroxidation, chemistry.chemical_compound, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Enos, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, lcsh:QH301-705.5, chemistry.chemical_classification, lcsh:R5-920, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, biology, Superoxide, Tetrahydrobiopterin, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, lcsh:Medicine (General), Peroxynitrite, medicine.drug, medicine.medical_specialty, Nitric Oxide Synthase Type III, Nitric Oxide, Nitric oxide, 03 medical and health sciences, Internal medicine, medicine, Humans, Reactive oxygen species, Organic Chemistry, biology.organism_classification, Preeclampsia, 030104 developmental biology, Endocrinology, chemistry, lcsh:Biology (General), Oxidative stress, Endothelial nitric oxide synthase, Endothelium, Vascular, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset gestational hypertension with (or without) proteinuria or end-organ failure, exclusively observed in humans. It is a leading cause of maternal morbidity affecting 3–7% of pregnant women worldwide. PE pathophysiology could result from abnormal placentation due to a defective trophoblastic invasion and an impaired remodeling of uterine spiral arteries, leading to a poor adaptation of utero-placental circulation. This would be associated with hypoxia/reoxygenation phenomena, oxygen gradient fluctuations, altered antioxidant capacity, oxidative stress, and reduced nitric oxide (NO) bioavailability. This results in part from the reaction of NO with the radical anion superoxide (O2•−), which produces peroxynitrite ONOO-, a powerful pro-oxidant and inflammatory agent. Another mechanism is the progressive inhibition of the placental endothelial nitric oxide synthase (eNOS) by oxidative stress, which results in eNOS uncoupling via several events such as a depletion of the eNOS substrate L-arginine due to increased arginase activity, an oxidation of the eNOS cofactor tetrahydrobiopterin (BH4), or eNOS post-translational modifications (for instance by S-glutathionylation). The uncoupling of eNOS triggers a switch of its activity from a NO-producing enzyme to a NADPH oxidase-like system generating O2•−, thereby potentiating ROS production and oxidative stress. Moreover, in PE placentas, eNOS could be post-translationally modified by lipid peroxidation-derived aldehydes such as 4-oxononenal (ONE) a highly bioreactive agent, able to inhibit eNOS activity and NO production. This review summarizes the dysfunction of placental eNOS evoked by oxidative stress and lipid peroxidation products, and the potential consequences on PE pathogenesis., Graphical abstract Image 1, Highlights • Physiological ROS production is enhanced during pregnancy. • eNOS is one of the main target of oxidative stress in PE placenta. • eNOS is S-glutathionylated in PE placentas. • eNOS is modified by lipid oxidation products in PE placentas.

Published
2021
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55. Estimating the 3D Time Variable Water Vapor Contents of the Troposphere from a Single GNSS Receiver

Author

Barriot, Jean-Pierre, Serafini, J., Sichoix, Lydie, and Benson-Rumiz, Alicia

Subjects
GNSS Receiver, Physics - Atmospheric and Oceanic Physics, Troposphere, Atmospheric and Oceanic Physics (physics.ao-ph), FOS: Physical sciences, 3D Time Variable Water Vapor Contents, ComputingMilieux_MISCELLANEOUS, [PHYS.PHYS.PHYS-AO-PH] Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], Physics::Atmospheric and Oceanic Physics
Abstract

We describe here a new algorithm to model the water contents of the atmosphere from GNSS slant wet delays relative to a single receiver. We first make the assumption that the water vapor contents are mainly governed by a scale height (exponential law), and secondly that the departures from this decaying exponential can be mapped as a set of low degree 3D Zernike functions (w.r.t. space) and Tchebyshev polynomials (w.r.t. time.) We give an example of inversion with data acquired over a one day time span at the Geodesy Observatory of Tahiti., Comment: Conference paper: 2013 International Conference on Earth Observations and Societal Impacts (2013 ICEO&SI), JUNE 23-25, Tainan. Taiwan

Published
2021
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56. Classification of the Zoonotic Hepatitis E Virus Genotype 3 Into Distinct Subgenotypes

Author

Florence Nicot, Chloé Dimeglio, Marion Migueres, Nicolas Jeanne, Justine Latour, Florence Abravanel, Noémie Ranger, Agnès Harter, Martine Dubois, Sonia Lameiras, Sylvain Baulande, Sabine Chapuy-Regaud, Nassim Kamar, Sébastien Lhomme, Jacques Izopet, Benson-Rumiz, Alicia, Equipements d'excellence - Equipement de biologie intégrative du cancer pour une médecine personnalisée - - ICGex2010 - ANR-10-EQPX-0003 - EQPX - VALID, Organisation et montée en puissance d'une Infrastructure Nationale de Génomique - - France-Génomique2010 - ANR-10-INBS-0009 - INBS - VALID, Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Plateforme de génomique [Institut Curie], Institut Curie [Paris], ANR-10-EQPX-0003,ICGex,Equipement de biologie intégrative du cancer pour une médecine personnalisée(2010), and ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010)

Subjects
Microbiology (medical), viruses, lcsh:QR1-502, Biology, medicine.disease_cause, phylogeny, Microbiology, Genome, lcsh:Microbiology, diversity, subtype, 03 medical and health sciences, Hepatitis E virus, Phylogenetics, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genotype, medicine, Clade, Genotyping, Original Research, 030304 developmental biology, Genetics, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Molecular epidemiology, 030306 microbiology, virus diseases, digestive system diseases, full-length genome, HEV-3, classification, GenBank, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Hepatitis E virus (HEV) genotype 3 is the most common genotype linked to HEV infections in Europe and America. Three major clades (HEV-3.1, HEV-3.2, and HEV-3.3) have been identified but the overlaps between intra-subtype and inter-subtype p-distances make subtype classification inconsistent. Reference sequences have been proposed to facilitate communication between researchers and new putative subtypes have been identified recently. We have used the full or near full-length HEV-3 genome sequences available in the Genbank database (April 2020; n = 503) and distance analyses of clades HEV-3.1 and HEV-3.2 to determine a p-distance cut-off (0.093 nt substitutions/site) in order to define subtypes. This could help to harmonize HEV-3 genotyping, facilitate molecular epidemiology studies and investigations of the biological and clinical differences between HEV-3 subtypes.

Published
2021
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57. Estimating the impact of public health strategies on the spread of SARS‐CoV‐2: Epidemiological modelling for Toulouse, France

Author

Dimeglio, Chloé, Miedougé, Marcel, Loubes, Jean‐michel, Mansuy, Jean‐michel, Izopet, Jacques, Benson-Rumiz, Alicia, Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, SARS-CoV-2, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, public health, statistical model, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting disease COVID-19 has killed over 2 million people as of 22 January 2021. We have used a modified susceptible, infected, recovered epidemiological model to predict how the spread of the virus in France will vary depending on the public health strategies adopted, including anti-COVID-19 vaccination. Our prediction model indicates that the French authorities' adoption of a gradual release from lockdown could lead in March 2021 to a virus prevalence similar to that before lockdown. However, a massive vaccination campaign initiated in January 2021 and the continuation of public health measures over several months could curb the spread of virus and thus relieve the load on hospitals.

Published
2021
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58. Impact of chest computed tomography scan on the management of patients with chronic cough

Author

Marianne Lescouzeres, Roger Escamilla, Danièle Brouquières, Marie-Françoise Napoléon, Laurent Guilleminault, Alain Didier, Mathilde Descazeaux, Benson-Rumiz, Alicia, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Clinique rive gauche

Subjects
Pulmonary and Respiratory Medicine, Abnormal chest, medicine.medical_specialty, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Dry cough, business.industry, Chest ct, Computed tomography, Research Letters, Chronic cough, chronic cough, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, In patient, Radiology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Chronic cough (CC), defined as cough lasting for more than 8 weeks, is a common reason for consultation in general and respiratory medicine. CC is a complex entity with potential multiple causes. CC management has been described in American and European guidelines [1, 2]. Lung function tests and chest radiography are mandatory as first-line diagnostic work-up in CC. However, the usefulness of chest computed tomography (CT) in CC management has not been clearly identified. According to European guidelines, clinicians should not routinely perform a chest CT scan in CC patients presenting normal chest radiography and physical examination [1]. On the other hand, considering the American guidelines, a chest CT scan has to be taken into account in patients with normal chest radiography and after ruling out common causes of CC [2]. However, no criteria regarding chest CT scan in CC patients have been clearly established. In order to provide data on chest CT scans in CC management, our study aims to determine the impact of chest CT scans on the management of patients with CC., A quarter of chronic cough (CC) patients have an abnormal chest CT scan but the effect of this on CC management is limited. Chest CT scan should not be routinely performed in CC, particularly in patients with dry cough. https://bit.ly/3Bl3EeE

Published
2021
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59. Quantifying the impact of public health protection measures on the spread of SARS-CoV-2

Author

Jacques Izopet, Jean-Michel Mansuy, Chloé Dimeglio, Jean-Michel Loubes, Benson-Rumiz, Alicia, Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Microbiology (medical), medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Article, Health services, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Environmental health, medicine, Humans, skin and connective tissue diseases, Epidemics, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, SARS-CoV-2, Public health, fungi, COVID-19, body regions, Geography, Infectious Diseases, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Statistical model, France, Public Health, Protective measures, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; The new virus, SARS-CoV-2, has probably affected millions of people world-wide since December 2019 and killed thousand. We have designed a model and used it to quantify the effect of local protective measures on the SARS-CoV-2 epidemic, assess their effectiveness and adapt health service strategies in Toulouse, France.

Published
2020
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60. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

Author

Sigrid Fra-Bido, Louise S. Matheson, Julien Novarino, Noudjoud Attaf, Silvia Innocentin, Nicolas Fazilleau, Louise M. C. Webb, Alexandre Bignon, Michelle A. Linterman, Benson-Rumiz, Alicia, The Babraham Institute [Cambridge, UK], Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Webb, Louise MC [0000-0003-3417-1484], Fra-Bido, Sigrid [0000-0003-2398-5191], Attaf, Noudjoud [0000-0001-7254-7679], Fazilleau, Nicolas [0000-0002-3574-5614], Linterman, Michelle A [0000-0001-6047-1996], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Receptors, CXCR5, Aging, Notch, T Follicular Helper Cells, Cellular differentiation, Biology, RBPJ, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Animals, Humans, Transcription factor, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, T follicular helper cell differentiation, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Effector, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, T-cell receptor, Cell Differentiation, Cell Biology, Original Articles, Cell biology, CXCR5, 030104 developmental biology, age, Ageing, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Female, Original Article, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

Ageing profoundly changes our immune system and is thought to be a driving factor in the morbidity and mortality associated with infectious disease in older people. We have previously shown that the impaired immunity to vaccination that occurs in aged individuals is partly attributed to the effect of age on T follicular helper (Tfh) cell formation. In this study, we examined how age intrinsically affects Tfh cell formation in both mice and humans. We show increased formation of Tfh precursors (pre‐Tfh) but no associated increase in germinal centre (GC)‐Tfh cells in aged mice, suggesting age‐driven promotion of only early Tfh cell differentiation. Mechanistically, we show that ageing alters TCR signalling which drives expression of the Notch‐associated transcription factor, RBPJ. Genetic or chemical modulation of RBPJ or Notch rescues this age‐associated early Tfh cell differentiation, and increased intrinsic Notch activity recapitulates this phenomenon in younger mice. Our data offer mechanistic insight into the age‐induced changes in T‐cell activation that affects the differentiation and ultimately the function of effector T cells., Ageing alters TCR signalling which drives expression of the Notch‐associated transcription factor, RBPJ. This results in enhanced differentiation into T follicular helper cell precursors.

Published
2020
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61. Ture aratai no te haavaraa tivira

Author

Gourdon, Pascal, Marchand, Johan, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, Polynésie française, Procédure civile, ComputingMilieux_MISCELLANEOUS, Codes
Abstract

International audience

Published
2020

62. La Polynésie française est-elle une colonie ?

Author

Sémir Al Wardi, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
Colonie, History, Polynésie française, Statut politique, [SHS.SCIPO] Humanities and Social Sciences/Political science, ComputingMilieux_MISCELLANEOUS, [SHS.SCIPO]Humanities and Social Sciences/Political science
Abstract

La Polynesie francaise a ete reinscrite dans la liste des pays a decoloniser de l’ONU le 17 mai 2013. La France n’a pas accepte cette reinscription et boycotte systematiquement les reunions du Comite des 24 contrairement aux seances consacrees a la Nouvelle-Caledonie. Mais la Polynesie francaise est-elle vraiment une colonie ? En fait, il n’y a pas de reponse claire car l’analyse est assez complexe : si juridiquement, la Polynesie n’est plus une colonie a proprement parler lorsque l’on considere le deroulement des elections et les veritables pouvoirs des elus locaux, elle reste toutefois un produit de la colonisation. Le rapport colonial, pour reprendre Michel Giraud, reste « fondateur de toute chose ». En ce sens, elle n’est pas une collectivite territoriale comme une autre car elle porte encore les stigmates de la colonisation. La question devrait etre plutot la Polynesie est-elle decolonisee ?

Published
2018
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63. Assessment of 4 Doses of SARS-CoV-2 Messenger RNA–Based Vaccine in Recipients of a Solid Organ Transplant

Author

Raphaelle Romieu-Mourez, Olivier Marion, Nassim Kamar, Jacques Izopet, Florence Abravanel, Chloé Couat, Arnaud Del Bello, Benson-Rumiz, Alicia, Département de Néphrologie et Transplantation d'organes [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)

Subjects
Adult, Male, MESH: COVID-19 / immunology, 2019-20 coronavirus outbreak, COVID-19 Vaccines, MESH: Antibodies, Viral / immunology, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MESH: SARS-CoV-2 / immunology, MESH: Transplant Recipients, Antibodies, Viral, MESH: COVID-19 Vaccines / therapeutic use, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Research Letter, Humans, Medicine, skin and connective tissue diseases, MESH: Antibodies, Viral / blood, Messenger RNA, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Middle Aged, biology, SARS-CoV-2, business.industry, Research, fungi, COVID-19, Organ Transplantation, General Medicine, Middle Aged, Virology, Transplant Recipients, respiratory tract diseases, body regions, Online Only, Infectious Diseases, MESH: Organ Transplantation, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, biology.protein, Female, Antibody, Solid organ transplantation, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; This case series study assesses whether a fourth dose of a SARS-CoV-2 messenger RNA (mRNA)–based vaccine is associated with improved anti–SARS-CoV-2 antibody response in solid organ transplant recipients in France.

Published
2021
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64. Une analyse de la participation de l'industrie des télécommunications au « due process » de l’IASB à l'aune de la théorie de la traduction

Author

Kohler, Hervé, Le Manh-Béna, Anne, Université de la Polynésie Française (UPF), Gouvernance et développement insulaire (GDI), Benson-Rumiz, Alicia, and Delcambre-Maillard, Elodie

Subjects
« due process », IASB, Télécommunications, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, théorie de la traduction, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

65. New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough

Author

McGarvey, L, Dupont, L, Birring, SS, Boyd, J, Chung, KF, Dabrowska, M, Domingo, C, Fontana, G, Guilleminault, L, Kardos, P, Millqvist, E, Morice, AH, Smith, JA, Van den Berg, JW, Van de Kerkhove, C, Coleman, C, Adcock, I, Dicpinigaitis, P, Geppetti, P, Gibson, P, Lai, K, Mazzone, S, Page, C, Pavord, I, Song, W-J, Queen's University [Belfast] (QUB), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), King‘s College London, The European Lung Foundation (ELF), Imperial College London, Medical University of Warsaw - Poland, Universitat Autònoma de Barcelona (UAB), Università degli Studi di Firenze = University of Florence (UniFI), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Red Cross Maingau Hospital = Klinik Maingau vom Roten Kreuz, University of Gothenburg (GU), Castle Hill Hospital, University of Manchester [Manchester], Isala Hospital, Universitair Ziekenhuis Leuven (UZ Leuven), Benson-Rumiz, Alicia, and Pavord, I

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, IMPACT, International Cooperation, education, MESH: Societies, Medical, Respiratory System, RECOMMENDATIONS, Double blind, 03 medical and health sciences, DOUBLE-BLIND, 0302 clinical medicine, medicine, Humans, COPD, 030212 general & internal medicine, MESH: Quality of Health Care, Intensive care medicine, MESH: Antitussive Agents / therapeutic use, Societies, Medical, health care economics and organizations, 11 Medical and Health Sciences, Quality of Health Care, Focus (computing), MESH: Humans, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Science & Technology, NEUROCOUGH Clinical Research Collaboration, business.industry, medicine.disease, Europe, RECEPTORS, Antitussive Agents, MESH: International Cooperation, Clinical research, Cough, 030228 respiratory system, Antitussive Agent, MESH: Cough / drug therapy, MESH: Europe, business, Life Sciences & Biomedicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Chronic cough is a common and troublesome clinical problem and currently there are no effective treatments [1]. While individual specialist cough clinics have been set up in some European countries, there is no formal mechanism to develop common management approaches. Furthermore, the vast majority of clinical trials of novel anti-tussive treatment have been conducted in a limited number of sites in the UK and USA, with little in the way of cough clinical trial infrastructure across Europe [2–7]. The NEw Understanding in the tReatment Of COUGH (NEUROCOUGH) Clinical Research Collaboration (CRC) seeks to address this through creating a platform allowing clinicians, together with researchers in academia and industrial partners across Europe and beyond, to exchange ideas and facilitate collaborations geared towards improved care and treatment for patients with cough. The core aims of NEUROCOUGH are to: 1) create a registry of Europe-wide specialist cough clinics operating according to agreed and standardised protocols; 2) establish a Europe-wide registry of “clinical trial ready” chronic cough patients suitable for multicentre experimental medicine studies and later phase precision medicine clinical trials; 3) seek public engagement to provide input into NEUROCOUGH based on the priorities and unmet needs of patients; and 4) encourage early career researchers and clinicians into the field of cough. In time, we envisage that NEUROCOUGH will bring clinicians, scientists, patients and industry together for larger-scale cough projects in a way that to date has not been possible. NEUROCOUGH will place Europe at the forefront of clinical improvements in chronic cough and provide a strong platform for attracting major clinical trials of anti-tussives, thus speeding up drug discovery with the ultimate aim of providing better treatments for patients with chronic cough.

Published
2019
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66. Eléments relatifs à l’ordre sociopolitique et religieux des temps anciens

Author

Saura, Bruno, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), Éric CONTE, and Benson-Rumiz, Alicia

Subjects
Histoire, [SHS.ANTHRO-SE] Humanities and Social Sciences/Social Anthropology and ethnology, Ordre religieux, Tahiti, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, ComputingMilieux_MISCELLANEOUS, Ordre sociopolitique
Abstract

International audience

Published
2019

68. Managing resistance and desire in language learning: a basic developmental and motivational process

Author

Scott, Stephen, Dubrac, Anne-Laure, Benson-Rumiz, Alicia, and DUBRAC, Anne-Laure

Subjects
soi, language learning, identité, resistance, apprentissage des langues, desire, self, motivation, désir, résistance, [SCCO.LING] Cognitive science/Linguistics, development, identity, développement
Abstract

This article highlights the complex and inseparable relation between desire and resistance in foreign language learning. An exploratory study based on semi-directive interviews with non-literary undergraduate students confirm that language learning is a highly subjective phenomenon. The results show that the way students learn to manage the “desire ↔ resistance relation” in their L2 learning has a decisive impact on their motivational and linguistic development., Cet article met en évidence la relation complexe et inséparable entre désir et résistance dans l’apprentissage d’une langue étrangère. Une enquête exploratoire, à partir d’entretiens semi-directifs réalisés avec des étudiants en secteur Lansad, montre que l’apprentissage d’une L2 est un phénomène hautement subjectif. La manière dont les étudiants parviennent à gérer la “relation désir ↔ résistance” dans le contexte de leur apprentissage influe fortement sur leur développement motivationnel et linguistique.

Published
2019

69. Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases

Author

Reem Al-Daccak, Jean-David Bouaziz, Nabila Jabrane-Ferrat, Enzo Manchon, Nell Hirt, Benson-Rumiz, Alicia, Impact of MEditerranean Diet, Inflammation and Microbiome on plaque vulnerability and microvascular dysfunction after an Acute Coronary Syndrome. A randomized, controlled, mechanistic clinical trial - - MEDIMACS2017 - ANR-17-HDIM-0005 - JPI HDHL - VALID, Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and ANR-17-HDIM-0005,MEDIMACS,Impact of MEditerranean Diet, Inflammation and Microbiome on plaque vulnerability and microvascular dysfunction after an Acute Coronary Syndrome. A randomized, controlled, mechanistic clinical trial(2017)

Subjects
skin, chronic inflammation, Cell type, Cell, regenerative medicine, Dermatitis, wound healing, Context (language use), Review, exosomes, Regenerative medicine, Theranostic Nanomedicine, Catalysis, Immunomodulation, lcsh:Chemistry, Inorganic Chemistry, Paracrine signalling, stem cells, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, Humans, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Regeneration (biology), Organic Chemistry, Biological Transport, General Medicine, Microvesicles, Computer Science Applications, Cell biology, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, Chronic Disease, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Stem cell, extracellular vesicles, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Endosome-derived small extracellular vesicles (EVs), often referred to as exosomes, are produced by almost all, if not all, cell types, and are critical for intercellular communication. They are composed of a lipid bilayer associated with membrane proteins and contain a payload of lipids, proteins and regulatory RNAs that depends on the parental cell physiological condition. By transferring their “cargo”, exosomes can modulate the phenotype of neighboring and distant cells. Stem cells (SC) were widely studied for therapeutic applications regarding their regenerative/reparative potential as well as their immunomodulatory properties. Whether from autologous or allogeneic source, SC beneficial effects in terms of repair and regeneration are largely attributed to their paracrine signaling notably through secreted EVs. Subsequently, SC-derived EVs have been investigated for the treatment of various diseases, including inflammatory skin disorders, and are today fast-track cell-free tools for regenerative/reparative strategies. Yet, their clinical application is still facing considerable challenges, including production and isolation procedures, and optimal cell source. Within the emerging concept of “allogeneic-driven benefit” for SC-based therapies, the use of EVs from allogeneic sources becomes the pragmatic choice although a universal allogeneic cell source is still needed. As a unique temporary organ that ensures the mutual coexistence of two allogeneic organisms, mother and fetus, the human placenta offers a persuasive allogeneic stem cell source for development of therapeutic EVs. Advancing cell-free therapeutics nurtures great hope and provides new perspectives for the development of safe and effective treatment in regenerative/reparative medicine and beyond. We will outline the current state of the art in regard of EVs, summarize their therapeutic potential in the context of skin inflammatory disorders, and discuss their translational advantages and hurdles.

Published
2021
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70. Metabolomic approach of the antiprotozoal activity of medicinal Piper species used in Peruvian Amazon

Author

Wilfredo Ruiz Mesía, Liliana Ruiz-Vásquez, Sandrine Cojean, Bruno Figadère, Pedro Vásquez-Ocmín, Alice Gadea, Anne-Cécile Van Baelen, Sébastien Pomel, Alexandre Maciuk, Lastenia Ruiz Mesía, Guillaume Marti, Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut de Recherche pour le Développement (IRD), Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Metatoul - Agromix, MetaToul-MetaboHUB, Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Laboratoire de Recherche en Sciences Végétales (LRSV), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonia (LIPNAA), Centro de Investigaciones de Recursos Naturales de la Amazonía (CIRNA), Universidad Nacional de la Amazonía Peruana [Loreto, Perou] (UNAP)-Universidad Nacional de la Amazonía Peruana [Loreto, Perou] (UNAP), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), MetaToul Agromix, MetaboHUB-MetaToul, and Benson-Rumiz, Alicia

Subjects
Plasmodium, MESH: Mesocricetus, MESH: Antimalarials / isolation & purification, Mice, 0302 clinical medicine, MESH: Ethnopharmacology / methods, Genus, Surveys and Questionnaires, Peru, Drug Discovery, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, MESH: Animals, Leishmania, 0303 health sciences, biology, Traditional medicine, Amazon rainforest, MESH: Antiprotozoal Agents / metabolism, 030220 oncology & carcinogenesis, Antiprotozoal, Female, MESH: Antimalarials / therapeutic use, antiprotozoal Activity, MESH: Leishmania donovani / drug effects, MESH: Metabolomics / methods, Trypanosoma, medicine.drug_class, Plasmodium falciparum, Antiprotozoal Agents, Leishmania donovani, Metabolomic, Antimalarials, 03 medical and health sciences, MESH: Antiprotozoal Agents / therapeutic use, parasitic diseases, Human Umbilical Vein Endothelial Cells, medicine, Animals, Humans, Metabolomics, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, HUVEC Cells, 030304 developmental biology, Pharmacology, Piper, Mesocricetus, Plant Extracts, MESH: Leishmania donovani / metabolism, 15. Life on land, biology.organism_classification, RAW 264.7 Cells, MESH: Antiprotozoal Agents / isolation & purification, Ethnopharmacology, MESH: Antimalarials / metabolism, MESH: Human Umbilical Vein Endothelial Cells / drug effects, MESH: Human Umbilical Vein Endothelial Cells / metabolism, Medicine, Traditional, Peruvian amazon
Abstract

International audience; Ethnopharmacological relevance : In the Peruvian Amazon as in the tropical countries of South America, the use of medicinal Piper species (cordoncillos) is common practice, particularly against symptoms of infection by protozoal parasites. However, there is few documented information about the practical aspects of their use and few scientific validation. The starting point of this work was a set of interviews of people living in six rural communities from the Peruvian Amazon (Alto Amazonas Province) about their uses of plants from Piper genus: one community of Amerindian native people (Shawi community) and five communities of mestizos. Infections caused by parasitic protozoa take a huge toll on public health in the Amazonian communities, who partly fight it using traditional remedies. Validation of these traditional practices contributes to public health care efficiency and may help to identify new antiprotozoal compounds.Aims of study : To record and validate the use of medicinal Piper species by rural people of Alto Amazonas Province (Peru) and annotate active compounds using a correlation study and a data mining approach.Materials and methods : Rural communities were interviewed about traditional medication against parasite infections with medicinal Piper species. Ethnopharmacological surveys were undertaken in five mestizo villages, namely: Nueva Arica, Shucushuyacu, Parinari, Lagunas and Esperanza, and one Shawi community (Balsapuerto village). All communities belong to the Alto Amazonas Province (Loreto region, Peru). Seventeen Piper species were collected according to their traditional use for the treatment of parasitic diseases, 35 extracts (leaves or leaves and stems) were tested in vitro on P. falciparum (3D7 chloroquine-sensitive strain and W2 chloroquine-resistant strain), Leishmania donovani LV9 strain and Trypanosoma brucei gambiense. Assessments were performed on HUVEC cells and RAW 264.7 macrophages. The annotation of active compounds was realized by metabolomic analysis and molecular networking approach.Results : Nine extracts were active (IC50 ≤ 10 μg/mL) on 3D7 P. falciparum and only one on W2 P. falciparum, six on L. donovani (axenic and intramacrophagic amastigotes) and seven on Trypanosoma brucei gambiense. Only one extract was active on all three parasites (P. lineatum). After metabolomic analyses and annotation of compounds active on Leishmania, P. strigosum and P. pseudoarboreum were considered as potential sources of leishmanicidal compounds.Conclusions : This ethnopharmacological study and the associated in vitro bioassays corroborated the relevance of use of Piper species in the Amazonian traditional medicine, especially in Peru. A series of Piper species with few previously available phytochemical data have good antiprotozoal activity and could be a starting point for subsequent promising work. Metabolomic approach appears to be a smart, quick but still limited methodology to identify compounds with high probability of biological activity.

Published
2021
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71. Vulnérabilité des systèmes associés aux monts sous-marins face au changement global

Author

Gaertner, J-C., Lepetit, Camille, Taquet, Marc, Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Benson-Rumiz, Alicia

Subjects
Monts sous-marins, Changement global, Vulnérabilité, Systèmes associés, [SDU.STU.OC] Sciences of the Universe [physics]/Earth Sciences/Oceanography, ComputingMilieux_MISCELLANEOUS, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience

Published
2018

72. Au service des langues et de leur enseignement : l'humaniste plurilingue Jacques Bourgoing

Author

Cézard-Leyral, Marie, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
French, vernaculaires, formation, Language's history, français, Multilingualism, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, histoire de la langue, plurilinguisme, humanisme, 16e siècle, Humanism, latin, Académie, Training, Vernaculars, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, Jacques Bourgoing, Academy
Abstract

While medieval intellectual circles valued no languages other than ancient, in the sixteenth century the advent of vernaculars on the linguistic scene started to reverse this balance of power. Against such a backdrop of multilingual tensions, Jacques Bourgoing positioned himself by publishing in 1583 an unfinished dictionary drafted in Latin: De origine, usu et ratione vulgarium vocum linguae Gallicae, Italicae et Hispanicae 2. To expound the etymology and usage of vernacular words and expressions, the author makes reference to Hebrew and Greek when necessary, but also, besides French, to Italian and Spanish. What does this eclectic book tell us, from diachronic and synchronic perspectives, about the connections between languages in the sixteenth century, that is, about how related, complementary, interacting or competing they were? This atypical work resonates with current debates on French and regional languages, even if the roles are now switched, with French, just like Latin before, as the dominant language. Indeed, this dictionary participates in very contemporary issues coupled with educational questions, as illustrated by Jacques Bourgoing, founding as a teacher a Paris Multidisciplinary Academy in 1598. To what extent did his metalinguistic reflections sustain his pedagogical ambitions? What does he tell us about language history and teaching? From an angle both linguistic and educational, our analysis means to establish the modernity of concerns that he overtly proffered, not to say upheld, in support of multilingualism., Alors que les cercles intellectuels médiévaux n'estimaient que les langues antiques, le rapport de force tend à s'inverser au XVI e siècle avec l'avènement sur la scène linguistique des vernaculaires. C'est dans ce contexte de tensions multilingues que se positionne Jacques Bourgoing, qui publie en 1583 un dictionnaire inachevé rédigé en latin : De origine, usu et ratione vulgarium vocum linguae Gallicae, Italicae et Hispanicae 1. L'auteur y convoque au besoin l'hébreu, le grec, mais encore l'italien et l'espagnol, en plus du français, pour exposer l'étymologie et l'usage de mots et expressions vernaculaires. Que nous dit cet ouvrage éclectique du rapport entre les langues au XVI e siècle, de leurs parentés, interactions, complémentarités ou rivalités, d'un double point de vue diachronique et synchronique ? Cette oeuvre atypique entre en résonance avec les réflexions actuelles autour du français et des langues régionales, même si les rôles se sont inversés puisque c'est à présent le français qui occupe, comme le latin autrefois, la place de langue dominante. Elle rejoint ainsi des problématiques très contemporaines en se doublant d'une visée éducative : Jacques Bourgoing le pédagogue fonde en effet en 1598 une Académie parisienne pluridisciplinaire. Dans quelle mesure sa réflexion métalinguistique nourrit-elle son ambition pédagogique ? Que nous apprend-il de l'histoire des langues et de l'enseignement ? Dans un double cadre linguistique et éducatif, notre analyse conduira à établir la modernité de ses préoccupations, au service d'un plurilinguisme assumé voire revendiqué.

Published
2018

73. Signal compensation optical coherence tomography system and method

Author

Strouthidis, N, Girard, M. J. A., Mari, Jean-Martial, Mehta, J, Foin, N., Géopôle du Pacifique Sud (GePaSUD), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
[SPI]Engineering Sciences [physics], [SPI] Engineering Sciences [physics], Optical coherence, Signal compensation, Tomography system and method
Published
2018

74. Méthodes et outils pour améliorer les conditions de résilience et faire face aux risques

Author

Serre, Damien, Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), RESIPOL, and Benson-Rumiz, Alicia

Subjects
Risques, [QFIN.RM] Quantitative Finance [q-fin]/Risk Management [q-fin.RM], [QFIN.RM]Quantitative Finance [q-fin]/Risk Management [q-fin.RM], Résilience, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

75. Le choix des sanctions

Author

Emmanuelle Gindre, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), Université de la Polynésie française, and Benson-Rumiz, Alicia

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, Sanctions, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

76. Glucosinolates in three Brassicales of French Polynesia

Author

Montaut, S., Raharivelomanana, Phila, Butaud, Jean-François, Rollin, P., Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), TECHNOFAN, Groupe Safran, and Benson-Rumiz, Alicia

Subjects
Glucosinolates, French Polynesia, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Brassicales, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

77. Biogeographical diversity of Calophyllum inophyllum L. oil composition in the South Pacific region

Author

Lecellier, G., Ginigini, J., Nicolas, M., Nour, M., Hnawia, E., Lebouvier, N., Herbette, G., Lockhart, P., Raharivelomanana, Phila, Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Benson-Rumiz, Alicia

Subjects
Biogeographical diversity, South Pacific region, Calophyllum inophyllum L, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Oil composition, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

78. Sugar cane and Saccharum genus in French Polynesia, historical and potential uses for the future

Author

Vitrac, M., Teai, Taivini, Goebel, F.-R., Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Benson-Rumiz, Alicia

Subjects
Saccharum genus, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, historical uses, French Polynesia, Sugar cane, ComputingMilieux_MISCELLANEOUS, Potential uses
Abstract

International audience

Published
2018

79. Recentering Nordhoff and Hall's Bounty narrative on Oceania

Author

Largeaud-Ortega, Sylvie, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), University of Hawai‘i at Mānoa (UHM), and Benson-Rumiz, Alicia

Subjects
[SHS.LITT] Humanities and Social Sciences/Literature, [SHS.LITT]Humanities and Social Sciences/Literature, Charles Nordhoff, Oceania, James Norman Hall, ComputingMilieux_MISCELLANEOUS, Bounty narrative
Abstract

International audience

Published
2018

80. The evolutions of religion in the workplace in France

Author

Honoré, Lionel, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
Religion, [SHS.GESTION]Humanities and Social Sciences/Business administration, France, [SHS.GESTION] Humanities and Social Sciences/Business administration, Workplace, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

81. Entre « historiographie tragique » et « théâtralité », la mimêsis du tyran grec

Author

Bouyssou, Gerbert, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
Théâtre, Théâtralité, [SHS.HIST] Humanities and Social Sciences/History, Historiographie, Tyran, Grèce, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

82. Les ordres publics nationaux

Author

Sana-Chaillé de Néré, Sandrine, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
Ordres publics nationaux, [SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

83. Obtention de cristaux de carbonate de calcium in vitro à partir de protéines isolées du manteau de Pinctada margaritifera

Author

Schmitt, Nelly, Brahmi, Chloé, Demoy-Schneider, Marina, Lexcellent-Bissler, L., Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Université de la Polynésie française, and Benson-Rumiz, Alicia

Subjects
Manteau Pinctada margaritifera, In vitro, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Protéines isolées, ComputingMilieux_MISCELLANEOUS, Cristaux de carbonate de calcium
Abstract

International audience

Published
2018

84. Society Islanders turned pirates at the very beginning of 19th c. some short-lived and puzzling violence cases

Author

Dorbe-Larcade, Véronique, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), Université de la Polynésie française, and Benson-Rumiz, Alicia

Subjects
Pirates, [SHS.HIST] Humanities and Social Sciences/History, 19th century, Society Islanders, Violence, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

85. La Gouvernance du tourisme en Polynésie française

Author

Rival, Yann, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), Université de la Polynésie française, and Benson-Rumiz, Alicia

Subjects
[SHS.GEO] Humanities and Social Sciences/Geography, Tourisme, Polynésie française, Gouvernance, [SHS.GEO]Humanities and Social Sciences/Geography, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

86. Maori warriors and Tahitian vahine – cut from the same cloth ?

Author

Largeaud-Ortega, Sylvie, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), Université de la Polynésie française, and Benson-Rumiz, Alicia

Subjects
Tahitian vahine, [SHS.ANTHRO-SE] Humanities and Social Sciences/Social Anthropology and ethnology, Maori warriors, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

87. L’esthétique de la morsure ou l’anticapitalisme dans Quand le cannibale ricane de Paul Tavo

Author

Pfersmann, Andréas, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), Université de la Pomynésie française, and Benson-Rumiz, Alicia

Subjects
[SHS.LITT] Humanities and Social Sciences/Literature, Paul Tavo, [SHS.LITT]Humanities and Social Sciences/Literature, Aanticapitalisme, Quand le cannibale ricane, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

88. The trajectories of women entrepreneur in French Polynesia

Author

Honoré, Lionel, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), Université de la Polynésie française, and Benson-Rumiz, Alicia

Subjects
Women entrepreneur, French Polynesia, [SHS.GESTION]Humanities and Social Sciences/Business administration, [SHS.GESTION] Humanities and Social Sciences/Business administration, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

89. Pitcairn before the mutineers: Revisiting the isolation of a Polynesian Island

Author

Aymeric Hermann, Guillaume Molle, Department of Linguistic and Cultural Evolution (DLCE), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Ethnologie préhistorique, Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), School of Archaeology and Anthropology, Australian National University, Sylvie Largeaud-Ortega, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), and Benson-Rumiz, Alicia

Subjects
[SHS.ANTHRO-SE] Humanities and Social Sciences/Social Anthropology and ethnology, 010506 paleontology, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, 060102 archaeology, Isolation (health care), [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Pitcairn, Zoology, 06 humanities and the arts, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, 01 natural sciences, Isolation, Geography, Polynesian Islands, 0601 history and archaeology, 14. Life underwater, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

The myth of Pitcairn, building on the destiny of the Bounty mutineers, focuses on the recent history of this island as the epitome of marginality and isolation. Human occupation of the island, however, occurred long before the Bounty settlement, and Pitcairn provides a fascinating example of Polynesian sustainability that is little known to the general public. Located at the eastern fringe of Central Eastern Polynesia, the Pitcairn group includes the volcanic island of Pitcairn (4.5 square kilometres), the elevated limestone island of Henderson (37.2 square kilometres) and the two small atolls of Oeno and Ducie (Figure 2.1). Situated approximately 400 kilometres east of the Gambier Islands and 1,700 kilometres west of Rapa Nui/Easter Island, this island group is one of the world’s most geographically isolated.

Published
2018

90. Les médecines alternatives et complémentaires – une influence minoritaire – vers une démarginalisation

Author

Favro, Patrick, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), Frédéric Pugnière-Saavedra, Jacques Fischer-Lokou, and Benson-Rumiz, Alicia

Subjects
Médecines alternatives, [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology, Médecines complémentaires, Changement social, ComputingMilieux_MISCELLANEOUS, Marginalité, Normes sociales
Abstract

International audience

Published
2018

91. Ethnopharmacological study and phytotherapy in French Polynesia (Raiatea and Tahaa islands)

Author

Quenon, C., Butaud, Jean-François, Ho, Raimana, Boquet, L., Samaillie, J., Lehartel, T., Rivière, C., Bordage, S., Hennebelle, T., Roumy, V., Sahpaz, S., Raharivelomanana, Phila, Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Benson-Rumiz, Alicia

Subjects
Islands, Ethnopharmacologice, French Polynesia, Tahaa, Raiatea, [SDV.BV.PEP] Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, ComputingMilieux_MISCELLANEOUS, Phytotherapy, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy
Abstract

International audience

Published
2018

92. La lutte contre la corruption et les entreprises en Polynésie française

Author

Cabon, Sarah-Marie, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
Entreprises, [SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, Lutte contre la corruption, Polynésie française, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

93. La banane, fruit aux multiples facettes

Author

WHITE, Raihei, Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Benson-Rumiz, Alicia

Subjects
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, ComputingMilieux_MISCELLANEOUS, Bananes
Abstract

International audience

Published
2018

94. Happiness – modern vs ancient Greek perceptions

Author

Favro, Patrick, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
[SHS.PSY] Humanities and Social Sciences/Psychology, Happiness, Modern perceptions, Ancient Greek perceptions, [SHS.PSY]Humanities and Social Sciences/Psychology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

95. Optimism – a systematized approach to a challenging concept

Author

Favro, Patrick, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
[SHS.PSY] Humanities and Social Sciences/Psychology, Optimism, [SHS.PSY]Humanities and Social Sciences/Psychology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

96. Au commencement était le droit de la concurrence

Author

Venayre, Florent, Gouvernance et développement insulaire (GDI), Université de la Polynésie Française (UPF), Haut-Commissariat de la République en Polynésie Française, and Benson-Rumiz, Alicia

Subjects
Droit, [SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, Concurrence, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

97. The Ranking of Africa in Daily Global Lightning Activity

Author

Williams, E., Guha, A., Liu, Y., Boldi, R., Pracser, E., Said, R., Sátori, G., Bozoki, T., Bor, J., Atkinson, M., Beggan, C., Cummer, S., Lyu, F., Fain, B., Hobara, Y., Koloskov, A., Kulak, A., McCraty, R., Mlynarczyk, J., Montanya, J., Moore, R., Neska, M., ortega, pascal, Price, C., Rawat, R., Sato, M., Sinha, A., Yampolski, Y., Division of Engineering and Applied Sciences, Lomonosov Moscow State University (MSU), Geodetic and Geophysical Research Institute (GGRI), Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPC2E), Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Electrical Engineering Departement, Technical University of Catalogna, emlyon business school, Géopôle du Pacifique Sud (GePaSUD), Université de la Polynésie Française (UPF), Indian Institute of Geomagnetism [Navi Mumbai, India] (IIG), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Benson-Rumiz, Alicia, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
Daily global lightning activity, Africa, [SDU.STU] Sciences of the Universe [physics]/Earth Sciences, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

98. Chemodiversity of New Caledonian liverworts from Bazzaniaoideae sub-family

Author

Métoyer, B., Lebouvier, N., Hnawia, E., Herbette, G., Thouvenot, L., Raharivelomanana, Phila, Nour, M., Asakawa, Yoshinori, Institut de sciences exactes et appliquées (ISEA), Université de la Nouvelle-Calédonie (UNC), Spectropôle - Aix Marseille Université (AMU SPEC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Ecole polytechnique, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD), and Benson-Rumiz, Alicia

Subjects
Chemodiversity, New Caledonian, Liverworts, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Bazzaniaoideae sub-family, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

99. Le rapport des étudiants de l’ESPE de la Polynésie à l’apprendre et à l’enseigner dans le 1er degré

Author

Reea, Goenda, Sociétés Traditionnelles et Contemporaines en Océanie (EA 4241) (EASTCO), Université de la Polynésie Française (UPF), and Benson-Rumiz, Alicia

Subjects
[SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, Polynésie française, 1er degré, ComputingMilieux_MISCELLANEOUS, Etudiants, ESPE, Apprentissage, Enseigneent
Abstract

International audience

Published
2018

100. Diversité, écologie et potentiel biotechnologique des algues brunes proliférantes dans les lagons de Polynésie française

Author

Tohei, Theophilus, Ecosystèmes Insulaires Océaniens (UMR 241) (EIO), Université de la Polynésie Française (UPF)-Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Université de la Polynésie Française, and Benson-Rumiz, Alicia

Subjects
Diversité, Ecologie, Potentiel biotechnologique, Lagons, Polynésie française, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Algues brunes proliférantes, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

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