125 results on '"Hideaki Matsui"'
Search Results
52. Auditory event-related potentials in Parkinson's disease: Prominent correlation with attention
- Author
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Hideaki Matsui, Kazuto Nishinaka, Masaya Oda, Tamotsu Kubori, and Fukashi Udaka
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Male ,medicine.medical_specialty ,Parkinson's disease ,Auditory event ,Disease ,Neuropsychological Tests ,Audiology ,Correlation ,mental disorders ,medicine ,Humans ,Dementia ,Latency (engineering) ,Aged ,Aged, 80 and over ,Electroencephalography ,Parkinson Disease ,medicine.disease ,Event-Related Potentials, P300 ,nervous system diseases ,Acoustic Stimulation ,Neurology ,Evoked Potentials, Auditory ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology - Abstract
Objective : Auditory P300 has been reported to be abnormal in demented patients with Parkinson's disease. However, it is still controversial which factors in Parkinson's disease influence P300 parameters. Methods : Forty patients with Parkinson's disease were included. Patients were divided into two groups: patients with dementia (PDD) and without dementia (PDND). An ‘odd-ball’ paradigm was used for auditory event-related potentials. Results : P300 latency was markedly delayed in PDD patients. Age and DRS1 (attention) were the most important factors influencing P300 latency. Conclusions : Although there have been reports of P300 in the past, its abnormalities reflect the deficit of attention in Parkinson's disease.
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- 2007
53. Thalamic Hyperperfusion in Verbal Hallucination of Parkinsonian Patients
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Kazuto Nishinaka, Masaya Oda, Hideaki Matsui, Takafumi Miyoshi, Tamotsu Kubori, Fukashi Udaka, and Narihiro Hara
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Male ,Elementary hallucination ,medicine.medical_specialty ,Parkinson's disease ,Hallucinations ,Perfusion scanning ,Audiology ,Internal Medicine ,medicine ,Humans ,Psychiatry ,Aged ,Tomography, Emission-Computed, Single-Photon ,Auditory hallucination ,business.industry ,Parkinson Disease ,General Medicine ,Middle Aged ,medicine.disease ,Cerebrovascular Circulation ,Regional Blood Flow ,Thalamic Nuclei ,Female ,medicine.symptom ,business - Abstract
Objective We compared brain perfusion image using 3D-SSP analysis of 123I-IMP SPECT between Parkinson's disease patients with auditory verbal hallucination and those without auditory hallucination. Methods Eighty-three cases with Parkinson's disease were studied. In 6 of these patients, auditory hallucination was noted. Among them, four cases had verbal hallucination and two other cases had elementary hallucination. Auditory hallucination was not found in the other 77 cases. Results Right thalamic perfusion was significantly increased in the verbal hallucination group compared to the group that lacked auditory hallucination. Conclusion In Parkinson's disease, the right thalamic hyperactive state may be related to verbal hallucination.
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- 2007
54. Depression in Parkinson’s disease
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Kenichi Komatsu, Hideaki Matsui, Hidekazu Niikawa, Kazuto Nishinaka, Fukashi Udaka, Tamotsu Kubori, and Masaya Oda
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Male ,medicine.medical_specialty ,Neurology ,Parkinson's disease ,Gyrus Cinguli ,Central nervous system disease ,Degenerative disease ,Internal medicine ,Fractional anisotropy ,medicine ,Humans ,Psychiatry ,Pathological ,Depression (differential diagnoses) ,Aged ,Depressive Disorder ,Parkinson Disease ,medicine.disease ,Frontal Lobe ,nervous system diseases ,Diffusion Magnetic Resonance Imaging ,Cardiology ,Anisotropy ,Anxiety ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology - Abstract
The pathophysiology of depression and anxiety in Parkinson’s disease remains obscure. We aimed to compare the fractional anisotropy (FA) values of Parkinson’s disease (PD) patients with and without depression to investigate the nature of depression in PD. Twenty-eight patients were divided into two groups: those with depression and those without. Diagnosis of depression was made using the DSM-IV criteria. Patients in the two groups were matched for Hoehn Yahr stage. There were significant reductions in FA values in the bilateral frontal ROIs possibly representing anterior cingulate bundles. The anterior cingulate bundles play an important role in depression in PD, and some aspects of depression in PD have pathological processes in common with de novo depression.
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- 2006
55. Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease
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Narihiro Hara, Kenichi Komatsu, Kazuto Nishinaka, Fukashi Udaka, Hideaki Matsui, Tamotsu Kubori, and Masaya Oda
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Male ,medicine.medical_specialty ,Parkinson's disease ,Perseveration ,Perfusion scanning ,Neuropsychological Tests ,Scintigraphy ,Wisconsin Card Sorting Test ,Internal medicine ,Image Processing, Computer-Assisted ,medicine ,Humans ,Prefrontal cortex ,Aged ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,Parkinson Disease ,Iofetamine ,medicine.disease ,Neurology ,Cerebrovascular Circulation ,Data Interpretation, Statistical ,Posterior cingulate ,Cardiology ,Female ,Neurology (clinical) ,Radiopharmaceuticals ,Geriatrics and Gerontology ,medicine.symptom ,Psychology ,Neuroscience ,Perfusion ,Psychomotor Performance - Abstract
Background Few imaging studies investigated frontal dysfunctions in Parkinson's disease. Objectives We investigated relationships between Wisconsin Card Sorting Test (WCST) and brain perfusion in patients with non-demented Parkinson's disease. Methods Patients were divided into two groups according to WCST score: (1) CA (number of category achieved)≤2 or (2) CA≥3. We performed three-dimensional stereotactic surface projection and volume of interest analysis using 123I-IMP scintigraphy. Results Hypoperfusions of the bilateral posterior cingulate, rostrodorsal prefrontal, and left frontopolar cortices were shown in CA≤2 group, with the left cingulate and right rostrodorsal prefrontal cortices showing prominent hypoperfusion. CA and PE (perseverative errors) scores significantly correlated with perfusion of the left posterior cingulate cortex. PE score also correlated with perfusion of the right rostrodorsal prefrontal cortex. Conclusion Data indicated participations of various regions in task achievement. Careful interpretation of WCST scores is required.
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- 2006
56. Disruptions of the fornix fiber in parkinsonian patients with excessive daytime sleepiness
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Masaya Oda, Kazuto Nishinaka, Tamotsu Kubori, Fukashi Udaka, Hidekazu Niikawa, Kenichi Komatsu, and Hideaki Matsui
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Male ,medicine.medical_specialty ,Parkinson's disease ,Fornix, Brain ,Excessive daytime sleepiness ,Gastroenterology ,Nerve Fibers ,Internal medicine ,Fractional anisotropy ,medicine ,Humans ,In patient ,Pathological ,Brain function ,Aged ,Epworth Sleepiness Scale ,Fornix ,Parkinson Disease ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,Neurology ,Data Interpretation, Statistical ,Nerve Degeneration ,Anisotropy ,Female ,Sleep Stages ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Psychology ,Neuroscience ,Psychomotor Performance - Abstract
Background Although excessive daytime sleepiness (EDS) in Parkinson's disease (PD) has received a great deal of attention, the underlying pathological mechanism of its development and the relative contributions of brain function to this process are poorly understood. Objective To compare the fractional anisotropy (FA) values of PD patients with EDS and those without EDS, and to investigate the mechanism of EDS in this disease. Methods Eleven patients with PD with EDS, 26 patients with PD without EDS and 10 controls participated in this study. Patients with an ESS (Epworth Sleepiness Scale) score ≥10 were defined as having EDS. The FA values of 5 regions of interest (ROI) including the fornix were compared between the three groups. Results There were significant reductions in FA values of the fornix fiber in patients with EDS. ESS scores had significant correlation with FA values of the fornix. Conclusions Our study is the first to find the fornix fiber degeneration in PD patients with EDS. These results indicate that fornix dysfunction may have some correlations with EDS in PD.
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- 2006
57. Impaired Visual Acuity as a Risk Factor for Visual Hallucinations in Parkinson’s Disease
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Fukashi Udaka, Tamotsu Kubori, Akiko Tamura, Masaya Oda, Kazuto Nishinaka, Masakuni Kameyama, and Hideaki Matsui
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Male ,medicine.medical_specialty ,Parkinson's disease ,Visual acuity ,Hallucinations ,genetic structures ,Statistics as Topic ,Visual Acuity ,Audiology ,Antiparkinson Agents ,Levodopa ,Central nervous system disease ,03 medical and health sciences ,0302 clinical medicine ,Degenerative disease ,Risk Factors ,Charles Bonnet syndrome ,medicine ,Humans ,030212 general & internal medicine ,Risk factor ,Aged ,Geriatrics ,Vision Tests ,Parkinson Disease ,Middle Aged ,medicine.disease ,eye diseases ,Visual Hallucination ,030227 psychiatry ,Surgery ,Psychiatry and Mental health ,Regression Analysis ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Mental Status Schedule ,Psychology - Abstract
Pathophysiology of hallucinations in Parkinson’s disease is poorly understood. This study investigated relationships between visual hallucinations and visual acuity. Twenty-six consecutive patients with Parkinson’s disease participated in this study. Patients were divided into two groups: patients with visual hallucinations (VH group) and those without visual hallucinations (no-VH group). Unaided and corrected eyesight was evaluated in all patients, and if frequent use of prescription glasses or contact lenses was involved, eyesight using these lenses was also measured as the patient’s own best eyesight. If a patient did not use prescription glasses or contact lenses, the patient’s own best eyesight was defined as the unaided eyesight. Multivariate regression analysis demonstrated that agonist use and best eyesight were different after the backward elimination method. Visual hallucinations were closely related not to uncorrected eyesight or unaided eyesight but to the patient’s best eyesight. It is suggested that impaired visual acuity is a risk factor for visual hallucinations.
- Published
- 2006
58. Identification of the zebrafish red nucleus using Wheat Germ Agglutinin transneuronal tracing
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Reinhard W. Köster, Kazuhiko Namikawa, and Hideaki Matsui
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Cerebellum ,Red nucleus ,Efferent ,wheat germ agglutinin ,Red Nucleus ,Wheat Germ Agglutinin ,Anatomy ,Biology ,Spinal cord ,Retrograde tracing ,Wheat germ agglutinin ,Article Addendum ,Midbrain ,medicine.anatomical_structure ,nervous system ,medicine ,red nucleus ,Midbrain tegmentum ,General Agricultural and Biological Sciences - Abstract
The red nucleus is located in the rostral midbrain of the vertebrate brain and controls motor coordination during locomotion. It receives input from the cerebellum and sends its output to the spinal cord. The presence of the red nucleus is well established in tetrapods, and its existence has also been suggested in teleosts but its presence and position has still been under discussion. By using wheat germ agglutinin (WGA) as a genetically encoded anterograde tracer, we recently identified contralateral projections from the cerebellum to a putative red nucleus in the zebrafish midbrain tegmentum. In this report we further revealed red nucleus derived from this contralateral afferent from the cerebellum using WGA and contralateral projections to the hindbrain-spinal cord junction site using DiI-mediated retrograde tracing. Thus the structure that we have identified by anterograde and retrograde tracing fulfills the anatomical demands for the red nucleus: the location in the midbrain tegmentum, contralateral afferent from the cerebellum (cerebello- ruber projection) and contralateral efferent to the spinal cord (rubro-spinal projection).
- Published
- 2014
59. Zebrafish jam-b2 Gal4-enhancer trap line recapitulates endogenous jam-b2 expression in extraocular muscles
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Hideaki, Matsui, Alessandro, Dorigo, Astrid, Buchberger, Jennifer C, Hocking, Martin, Distel, and Reinhard W, Köster
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Animals, Genetically Modified ,Junctional Adhesion Molecule B ,Animal Fins ,Animals ,Gene Expression Regulation, Developmental ,Zebrafish Proteins ,Muscle, Skeletal ,Zebrafish - Abstract
Members of the junctional adhesion molecule (JAM) family function as cell adhesion molecules and cell surface receptors. The zebrafish genome contains six different jam genes, and jam-b and jam-c were shown to be essential for myoblast fusion during skeletal muscle development. However, little is known about jam-b2 expression and function.We isolated the cDNA of zebrafish jam-b2. jam-b2 is expressed specifically in extraocular muscles (EOMs), jaw muscles, and pectoral fins in zebrafish larvae, but not in trunk muscles. The identified jam-b2 expression pattern is supported by the analysis of a zebrafish Gal4-enhancer trap line, in which the coding sequence of the transcriptional activator KalTA4 together with a Gal4-dependent UAS-mCherry expression cassette was inserted into the jam-b2 locus. Intercrosses with an UAS:EGFP strain proves the possibility for targeting transgene expression to EOMs, jaw muscles and fins. Finally, we characterized the concerted contraction pattern of EOMs in larvae performing an optokinetic response.The expression pattern of jam-b2 suggests that it may contribute different properties to EOMs, jaw muscles, and pectoral fins. The jam-b2:KalTA4-UAS-mCherry transgenic strain serves a dual role as both a reporter for these muscles and as a valuable genetic tool for targeting transgene expression to EOMs.
- Published
- 2014
60. Three-dimensional stereotactic surface projection study of orthostatic hypotension and brain perfusion image in Parkinson's disease
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Tamotsu Kubori, Hideaki Matsui, Takafumi Miyoshi, Masaya Oda, Fukashi Udaka, Kazuto Nishinaka, N. Hara, A. Tamura, and Masakuni Kameyama
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Male ,Parkinson's disease ,Perfusion scanning ,Single-photon emission computed tomography ,Gyrus Cinguli ,Iodine Radioisotopes ,Central nervous system disease ,Hypotension, Orthostatic ,Orthostatic vital signs ,Imaging, Three-Dimensional ,Degenerative disease ,Predictive Value of Tests ,Image Processing, Computer-Assisted ,medicine ,Humans ,Prospective Studies ,Pure autonomic failure ,Aged ,Tomography, Emission-Computed, Single-Photon ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Brain ,Parkinson Disease ,General Medicine ,Middle Aged ,medicine.disease ,Autonomic Nervous System Diseases ,Neurology ,Cerebrovascular Circulation ,Anesthesia ,Female ,Neurology (clinical) ,business ,Perfusion ,Software - Abstract
Objective – To compare brain perfusion image using three-dimensional stereotactic surface projection (3D-SSP) analysis of N-isopropyl-p-123I iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) between patients with Parkinson's disease with orthostatic hypotension and those without orthostatic hypotension. Materials and methods – Fifteen patients with Parkinson's disease and orthostatic hypotension and 13 patients with Parkinson's disease without orthostatic hypotension were studied. We compared brain perfusion image between the two groups by 3D-SSP. Results – Bilateral anterior cingulate gyrus perfusion of the patients with orthostatic hypotension was significantly decreased compared to that of the patients without orthostatic hypotension. Conclusions – The disorder of anterior cingulate gyrus may participate in the autonomic failure in Parkinson's disease.
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- 2005
61. Metaiodobenzylguanidine (MIBG) uptake in Parkinson’s disease also decreases at thyroid
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Akiko Tamura, Masakuni Kameyama, Masaya Oda, Kazuto Nishinaka, Fukashi Udaka, Tamotsu Kubori, and Hideaki Matsui
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Male ,medicine.medical_specialty ,Parkinson's disease ,Thyroid Gland ,Urology ,Disease ,Diagnosis, Differential ,Atrophy ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Aged ,Denervation ,business.industry ,Myocardium ,Parkinsonism ,Thyroid ,Heart ,Parkinson Disease ,General Medicine ,Middle Aged ,Multiple System Atrophy ,medicine.disease ,3-Iodobenzylguanidine ,Autonomic nervous system ,Endocrinology ,medicine.anatomical_structure ,Female ,Radiopharmaceuticals ,Differential diagnosis ,business - Abstract
Background: Decreased cardiac metaiodobenzylguanidine (MIBG) uptake was reported in Parkinson’s disease and this contributes to the differential diagnosis between Parkinson’s disease and other forms of parkinsonism such as multiple system atrophy. However, decreased MIBG uptake of the thyroid has not been demonstrated. Objective: To compare MIBG uptake of the thyroid among Parkinson’s disease, multiple system atrophy and controls. Methods: Twenty-six patients with Parkinson’s disease, 11 patients with multiple system atrophy and 14 controls were examined in this study. Planar images were taken 15 minutes (early images) and 3 hours (late images) after intravenous injection of 111 MBq 123 I-MIBG. Results: MIBG uptake of the thyroid on early images decreased significantly in Parkinson’s disease compared to controls (p < 0.0001) and multiple system atrophy (p = 0.018). MIBG uptake of the thyroid on early images decreased significantly also in multiple system atrophy compared to controls (p = 0.027). On late images, thyroid uptake differed significantly only between Parkinson’s disease and controls (p = 0.010). Conclusions: Our study is the first to demonstrate decreased MIBG uptake of the thyroid in Parkinson’s disease. Sympathetic nervous denervation of Parkinson’s disease occurred not only in the heart but also in the thyroid.
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- 2005
62. The Relation Between Visual Hallucinations and Visual Evoked Potential in Parkinson Disease
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Kazuto Nishinaka, Fukashi Udaka, Akiko Tamura, Masaya Oda, Tamotsu Kubori, Masakuni Kameyama, and Hideaki Matsui
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Male ,medicine.medical_specialty ,Hallucinations ,genetic structures ,Photic Stimulation ,Visual Physiology ,Disease ,Visual evoked potentials ,Audiology ,Stimulus (physiology) ,Reaction Time ,medicine ,Humans ,Pharmacology (medical) ,Evoked potential ,Aged ,Pharmacology ,Parkinson Disease ,Middle Aged ,Visual Hallucination ,P100 Latency ,Evoked Potentials, Visual ,Female ,Neurology (clinical) ,Psychology ,Neuroscience - Abstract
Objective: The pathophysiology of hallucinations in Parkinson disease is poorly understood. This study investigated the relation between visual hallucination and visual evoked potentials (VEPs) in Parkinson disease. Methods: Nineteen patients with Parkinson disease were studied. The authors divided patients into 2 groups: patients with visual hallucinations (VH group) and those without visual hallucinations (no-VH group). VEPs using a checkerboard stimulus were recorded under a drug-free state. Results: On multivariate regression analysis, only the average P100 latency was selected and remained significant after the backward elimination method. Conclusion: The authors demonstrated a close association between visual hallucinations and elongated VEP latency in Parkinson disease. VEPs may become one of the predictors for visual hallucination.
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- 2005
63. N-isopropyl-p-123I Iodoamphetamine Single Photon Emission Computed Tomography Study of Parkinson's Disease with Dementia
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Narihiro Hara, Kazuto Nishinaka, Hideaki Matsui, Tamotsu Kubori, Akiko Tamura, Fukashi Udaka, Takafumi Miyoshi, Masakuni Kameyama, and Masaya Oda
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Male ,medicine.medical_specialty ,Pathology ,Parkinson's disease ,Perfusion scanning ,Disease ,Single-photon emission computed tomography ,Central nervous system disease ,Degenerative disease ,Internal medicine ,mental disorders ,Internal Medicine ,medicine ,Humans ,Dementia ,Aged ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Parkinson Disease ,General Medicine ,Iofetamine ,medicine.disease ,nervous system diseases ,Cardiology ,Female ,Radiopharmaceuticals ,business ,Perfusion - Abstract
Background Intellectual deterioration occurs in 10-40% of patients with Parkinson’s disease. However, there are many conflicting studies on its relation with brain perfusion and the nature of this dementing process remains controversial.Objective To compare cortical perfusion by SPECT using 123I-IMP between Parkinson’s disease patients with dementia and those without dementia and to investigate the correlation between dementia in Parkinson’s disease and brain perfusion in various areas.Methods Fifty-two cases of Parkinson’s disease and 10 control cases were studied. The Parkinson’s disease with dementia group included 30 cases and the Parkinson’s disease without dementia group included 22 cases.,Results By multiple logistic regression method, we demonstrated significant hypoperfusion in the occipital cortex in Parkinson’s disease with dementia.Conclusions The cause of dementia in Parkinson’s disease may vary. We demonstrated that occipital hypoperfusion was closely correlated to dementia in Parkinson’s disease compared to frontal, parietal and temporal perfusion.
- Published
- 2005
64. Structures and Mixed-valence State in Ni(mnt) 2 Salts of Biferrocenes
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Hideaki Matsui, Hiroshi Moriyama, Shinya Suzuki, and Tomoyuki Mochida
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Valence (chemistry) ,Mössbauer effect ,Nitrile ,Chemistry ,Inorganic chemistry ,General Chemistry ,Crystal structure ,Condensed Matter Physics ,chemistry.chemical_compound ,Crystallography ,Electrical resistivity and conductivity ,Chemical preparation ,Molecule ,General Materials Science ,Metallocene - Abstract
Ni(mnt) 2 salts of 1′, 1′′′-diisopropyl-1,1′′-biferrocene ( 1 ) and 1′,l′′′-dibenzyl-1 ,1′′-biferrocene ( 2 ) have been prepared. Both complexes show segregated-stack crystal structure, consisting of a mixed-valent biferrocenium monocation and a Ni(mnt) 2 monoanion. The D-A ratio is 1:1 in both compounds. The trapped-valence state is demonstrated for 2 at room temperature.
- Published
- 2002
65. An optimized method for counting dopaminergic neurons in zebrafish
- Author
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Atsushi Sugie and Hideaki Matsui
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0301 basic medicine ,Noradrenergic neurons ,lcsh:Medicine ,Biochemistry ,chemistry.chemical_compound ,Aromatic Amino Acids ,0302 clinical medicine ,Animal Cells ,Medicine and Health Sciences ,Neurotoxin ,Amino Acids ,lcsh:Science ,Zebrafish ,Neurons ,Mammals ,Movement Disorders ,Multidisciplinary ,biology ,Organic Compounds ,Dopaminergic ,Neurodegeneration ,Fishes ,Brain ,Parkinson Disease ,Neurochemistry ,Neurodegenerative Diseases ,Animal Models ,Chemistry ,Experimental Organism Systems ,Neurology ,Osteichthyes ,Vertebrates ,Physical Sciences ,%22">Fish ,Locus Coeruleus ,Cellular Types ,Neurochemicals ,Anatomy ,Oxidopamine ,Research Article ,Protein Serine-Threonine Kinases ,Research and Analysis Methods ,03 medical and health sciences ,Model Organisms ,Hydroxyl Amino Acids ,medicine ,Animals ,Dopaminergic Neurons ,Organic Chemistry ,lcsh:R ,Organisms ,Chemical Compounds ,Biology and Life Sciences ,Proteins ,Cell Biology ,biology.organism_classification ,medicine.disease ,Disease Models, Animal ,030104 developmental biology ,chemistry ,Cellular Neuroscience ,Amniotes ,Tyrosine ,Locus coeruleus ,lcsh:Q ,Dopaminergics ,Neuroscience ,030217 neurology & neurosurgery - Abstract
In recent years, considerable effort has been devoted to the development of a fish model for Parkinson’s disease (PD) to examine the pathological mechanisms of neurodegeneration. To effectively evaluate PD pathology, the ability to accurately and reliably count dopaminergic neurons is important. However, there is currently no such standardized method. Due to the relatively small number of dopaminergic neurons in fish, stereological estimation would not be suitable. In addition, serial sectioning requires proficiency to not lose any sections, and it permits double counting due to the large size of some of the dopaminergic neurons. In this study, we report an optimized protocol for staining dopaminergic neurons in zebrafish and provide a reliable counting method. Finally, using our optimized protocol, we confirmed that administration of 6-hydroxydopamine (a neurotoxin) or the deletion of the PINK1 gene (one of the causative genes of familiar PD) in zebrafish caused significant reduction in the number of dopaminergic and noradrenergic neurons. In summary, this method will serve as an important tool for the appropriate evaluation and establishment of fish PD models.
- Published
- 2017
66. Functional regionalization of the teleost cerebellum analyzed in vivo
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Kazuhiko Namikawa, Hideaki Matsui, Andreas Babaryka, and Reinhard W. Köster
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Cerebellum ,Efferent ,Purkinje cell ,Optogenetics ,Efferent Pathways ,Brain mapping ,Animals, Genetically Modified ,Cerebellar Cortex ,Purkinje Cells ,Commentaries ,medicine ,Animals ,Calcium Signaling ,Efferent Pathway ,Zebrafish ,Brain Mapping ,Multidisciplinary ,Behavior, Animal ,biology ,biology.organism_classification ,medicine.anatomical_structure ,Cerebellar cortex ,Neuroscience - Abstract
There has been accumulating evidence for a regionalized organization of the cerebellum, which was mostly deduced from anatomical mapping of axonal projections of cerebellar afferents. A likewise regionalization of the cerebellar output has been suggested from lesion studies and dye-tracer experiments, but its physiological targets as well as the functional relevance of such an output regionalization are less clear. Ideally, such functional regionalization should be proven noninvasively in vivo. We here provide evidence for such a regionalization of the output from the cerebellar cortex by genetically encoded transneuronal mapping of efferent circuits of zebrafish Purkinje neurons. These identified circuits correspond to distinct regionalized Purkinje cell activity patterns in freely behaving zebrafish larvae during the performance of cerebellar-dependent behaviors. Furthermore, optogenetic interrogation of selected Purkinje cell regions during animal behavior confirms the functional regionalization of Purkinje cell efferents and reveals their contribution to behavior control as well as their function in controlling lateralized behavioral output. Our findings reveal how brain compartments serve to fulfill a multitude of functions by dedicating specialized efferent circuits to distinct behavioral tasks.
- Published
- 2014
67. Development of transaxle for hybrid vehicle
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Kouichi Kondo, Hideaki Matsui, Keijiro Ohshima, and Ryuji Ibaraki
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Engineering ,Powertrain ,business.industry ,Control engineering ,Transaxle ,Automotive engineering ,Generator (circuit theory) ,Hybrid system ,Automotive Engineering ,Hybrid power ,Hybrid vehicle ,Reduction (mathematics) ,business ,Continuously variable transmission - Abstract
Toyota has developed a new parallel hybrid power train system. This hybrid system achieved 50% reduction of CO2 emission in the 10–15 mode. The transaxle of this hybrid power train system contains a generator and a motor. It works as a continuously variable transmission by controlling the generator and the motor. The load for this transaxle and behavior of the power train under this hybrid system were analyzed by a simulation and an experiment. We designed the transaxle using the results.
- Published
- 2000
68. A Case of Laryngeal Web Diagnosed after Induction of Anesthesia
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Oka Kimura, Haruo Ookawa, Naoto Yamada, Tasuku Suzuki, Hideaki Matsui, and Yukie Kato
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medicine.medical_specialty ,Anesthetic induction ,business.industry ,Anesthesia ,Laryngeal web ,medicine ,business ,Surgery - Abstract
喉頭横隔膜症とは, 喉頭に先天性または後天性の膜様組織が形成される疾患である. 今回われわれは術前に特記すべき上気道症状を呈さず, 気管挿管時に偶然発見された喉頭横隔膜症を経験したので報告する. 患者は60歳, 男性. 慢性副鼻腔炎に対し全身麻酔下での両側上顎洞篩骨洞根本術が予定された. 気管チューブ挿入時, 声門下に抵抗があったためラリンジアルマスク挿入下に気管支鏡検査を施行したところ, 喉頭に膜様物が確認された. 患者は1997年に他院にて直腸癌の手術を施行されており, このときの麻酔記録上特記事項はなかったことから後天性の喉頭横隔膜症が疑われた. 同疾患は無症状の患者がいるため, 気管挿管時には注意が必要である.
- Published
- 2009
69. Multiple Sclerosis Following Splenectomy as a Treatment for Idiopathic Thrombocytopenic Purpura
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Masakuni Kameyama, Fukashi Udaka, Akiko Tamura, Masaya Oda, Tamotsu Kubori, Hideaki Matsui, and Kazuto Nishinaka
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Adult ,Pediatrics ,medicine.medical_specialty ,Multiple Sclerosis ,medicine.medical_treatment ,Splenectomy ,medicine.disease_cause ,Transverse myelitis ,Autoimmunity ,Internal Medicine ,medicine ,Humans ,Autoimmune disease ,Purpura, Thrombocytopenic, Idiopathic ,Dysesthesia ,business.industry ,Multiple sclerosis ,Optic Nerve ,General Medicine ,Hypoesthesia ,medicine.disease ,Magnetic Resonance Imaging ,Thrombocytopenic purpura ,Surgery ,Phenotype ,Evoked Potentials, Visual ,Female ,medicine.symptom ,business - Abstract
A 27-year-old woman was admitted to our hospital with tetraparesis, dysesthesia and hypoesthesia of all regions below the breasts, urinary disturbance, and difficulty in breathing. Since age 21 idiopathic thrombocytopenic purpura (ITP) was diagnosed and steroid therapy was continued. At age 26, she had splenectomy for her ITP. On admission, steroid pulse therapy was administered with a tentative diagnosis of transverse myelitis. Symptoms gradually ameliorated. At age 29, she gradually lost her left vision, and multiple sclerosis was diagnosed and steroid therapy was administered, and her left vision gradually ameliorated. There are several reports describing other autoimmune disorders that arise after splenectomy. Since the spleen acts as a major pool of type 2 helper T cells, it is plausible that peripheral type 1 helper T cell activity may increase after splenectomy, promoting the development of autoimmune disorders. We considered there would be a close relation between splenectomy for ITP and multiple sclerosis in this case.
- Published
- 2005
70. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates
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Hidefumi Ito, Jie Shen, Shunichi Takeda, Ryosuke Takahashi, Kengo Uemura, Hodaka Yamakado, Takakuni Maki, Norihito Uemura, Yoshito Kobayashi, Hideaki Matsui, Roberto Gavinio, Takeshi Asano, and Yoshihito Taniguchi
- Subjects
Fish Proteins ,Programmed cell death ,Dopamine ,Ubiquitin-Protein Ligases ,Oryzias ,PINK1 ,Substantia nigra ,Apoptosis ,Mitochondrion ,Biology ,Parkin ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Dopaminergic Cell ,Genetics ,medicine ,Animals ,Humans ,Molecular Biology ,Genetics (clinical) ,030304 developmental biology ,Neurons ,0303 health sciences ,Dopaminergic ,Parkinson Disease ,General Medicine ,Articles ,nervous system diseases ,Cell biology ,Mitochondria ,Disease Models, Animal ,Phenotype ,Gene Knockdown Techniques ,Vertebrates ,Drosophila ,Protein Kinases ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective dopaminergic cell loss in the substantia nigra, but its pathogenesis remains unclear. The recessively inherited familial PD genes PARK2 and PARK6 have been attributed to mutations in the Parkin and PTEN-induced kinase 1 (PINK1) genes, respectively. Recent reports suggest that PINK1 works upstream of Parkin in the same pathway to regulate mitochondrial dynamics and/or conduct autophagic clearance of damaged mitochondria. This phenomenon is preserved from Drosophila to human cell lines but has not been demonstrated in a vertebrate animal model in vivo. Here, we developed a medaka fish (Oryzias latipes) model that is deficient in Pink1 and Parkin. We found that despite the lack of a conspicuous phenotype in single mutants for Pink1 or Parkin, medaka that are deficient in both genes developed phenotypes similar to that of human PD: late-onset locomotor dysfunction, a decrease in dopamine levels and a selective degeneration of dopaminergic neurons. Further analysis also revealed defects in mitochondrial enzymatic activity as well as cell death. Consistently, PINK1 and Parkin double-deficient MEF showed a further decrease in mitochondrial membrane potential and mitochondrial complex I activity as well as apoptosis compared with single-deficient MEF. Interestingly, these mitochondrial abnormalities in Parkin-deficient MEF were compensated by exogenous PINK1, but not by disease-related mutants. These results suggest that PINK1 and Parkin work in a complementary way to protect dopaminergic neurons by maintaining mitochondrial function in vertebrates.
- Published
- 2013
71. ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons
- Author
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Manabu Funayama, Shigeto Sato, Ryosuke Takahashi, Norihito Uemura, Yasuo Uchiyama, Shunichi Takeda, Yoshihito Taniguchi, Shinji Saiki, Hideaki Matsui, Fumiaki Sato, Nobutaka Hattori, Yosuke Taruno, Hidefumi Ito, Yoshiyuki Sakaki, Masato Koike, and Atsushi Toyoda
- Subjects
ATPase ,Biophysics ,Oryzias ,Degeneration (medical) ,Biology ,medicine.disease_cause ,Endoplasmic Reticulum ,Biochemistry ,Cathepsin D ,Structural Biology ,Lysosome ,Cell Line, Tumor ,Genetics ,medicine ,Dementia ,Animals ,Humans ,ATP13A2 ,Molecular Biology ,Medaka fish ,Inclusion Bodies ,Mutation ,Endoplasmic reticulum ,Parkinsonism ,Dopaminergic Neurons ,Dopaminergic ,Cell Biology ,medicine.disease ,Molecular biology ,Protein Transport ,Proton-Translocating ATPases ,medicine.anatomical_structure ,Gene Knockdown Techniques ,Parkinson’s disease ,biology.protein ,Lysosomes - Abstract
Kufor-Rakeb syndrome (KRS) was originally described as an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 was identified as the causative gene in KRS. ATP13A2 encodes the ATP13A2 protein, which is a lysosomal type5 P-type ATPase, and ATP13A2 mutations are linked to autosomal recessive familial parkinsonism.Here, we report that normal ATP13A2 localizes in the lysosome, whereas disease-associated variants remain in the endoplasmic reticulum. Cathepsin D activity was decreased in ATP13A2-knockdown cells that displayed lysosome-like bodies characterized by fingerprint-like structures. Furthermore, an atp13a2 mutation in medaka fish resulted in dopaminergic neuronal death, decreased cathepsin D activity, and fingerprint-like structures in the brain. Based on these results, lysosome abnormality is very likely to be the primary cause of KRS/PARK9.
- Published
- 2013
72. TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency
- Author
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Claire E. Allen, Helen I. Woodroof, Aimee McTighe, Miratul M. K. Muqit, Rosemarie Soellner, Reinhard W. Köster, Heather Mortiboys, Philip W. Ingham, Marcus Keatinge, Paul R. Heath, Laura J. Flinn, Andreas S. Reichert, Lucy M. Brown, Sandrine Bretaud, Hideaki Matsui, Elena De Felice, Oliver Bandmann, and Marta Milo
- Subjects
Mitochondrial Diseases ,animal structures ,Morpholino ,ved/biology.organism_classification_rank.species ,Substantia nigra ,PINK1 ,Biology ,Mitochondrion ,Protein Serine-Threonine Kinases ,Animals, Genetically Modified ,ddc:570 ,Mitophagy ,Animals ,ddc:610 ,Model organism ,Zebrafish ,Genetics ,Gene knockdown ,ved/biology ,Dopaminergic Neurons ,fungi ,Parkinson Disease ,Original Articles ,Zebrafish Proteins ,biology.organism_classification ,Cell biology ,Mitochondria ,Disease Models, Animal ,Neurology ,Larva ,Original Article ,Neurology (clinical) ,Microglia ,Apoptosis Regulatory Proteins - Abstract
Autosomal recessively inherited, loss of function mutations in PTEN‐induced kinase 1 (PINK1) typically lead to early onset Parkinson disease (EOPD).1 The PINK1 protein is expressed ubiquitously throughout the human brain.2 Impaired mitochondrial function and morphology have been described in both human PINK1 mutant patient tissue and different PINK1‐deficient in vitro or in vivo model systems.3 PINK1 has also been implicated in oxidative stress defense, mitophagy, and the regulation of mitochondrial calcium homeostasis.3 However, the precise mechanisms leading to neuronal cell death remain unclear. Pink1 knockout mice do not develop loss of dopamine (DA) neurons in the substantia nigra and can therefore only be of limited use in investigating the mechanisms leading to neuronal cell death in human Parkinson disease (PD).6 Zebrafish are increasingly being used to model neurodegenerative diseases.7 As vertebrates, they are closer to humans than other genetically tractable model organisms such as Drosophila or Caenorhabditis elegans. Zebrafish embryos develop externally, are transparent, and have a well‐characterized DA nervous system.8 To date, investigations of the functional consequences of PD gene dysfunction in zebrafish have relied on the injection of morpholino antisense oligonucleotides (MOs).7 A major limitation of this approach is that MOs injected into the fertilized egg lose their effect within 3 to 5 days postfertilization, thus precluding investigation of the morphological, biochemical, or behavioral effects of gene dysfunction at larval and adult stages. In addition, morpholinos are frequently associated with nonspecific, off‐target effects.9 Previous studies using the MO strategy to investigate the effects of PINK1 deficiency in zebrafish have led to conflicting results.10 Using the targeting induced local lesions in genomes (TILLING) approach, we have now established a stable line carrying a premature stop mutation in the kinase‐encoding domain of pink1 (Y431*), the zebrafish orthologue of human PINK1. We provide confirmation that this mutation leads to inactivation of PINK1 catalytic activity and decreased mRNA stability. We further demonstrate that PINK1 deficiency in Danio rerio results in highly specific abnormalities in early development, which closely match the biochemical and morphological manifestations of the human disease, with persisting loss of dopaminergic neurons in adulthood and also persisting mitochondrial impairment. Genome‐wide gene expression studies identified upregulation of TigarB, the zebrafish homologue of the TP53‐induced glycolysis and apoptosis regulator (TIGAR).13 Remarkably, TigarB knockdown resulted in normalization of mitochondrial function and complete rescue of ascending dopaminergic neurons. Modulation of TIGAR‐related mechanisms may therefore be a promising novel strategy to develop disease‐modifying therapy for PINK1‐related PD.
- Published
- 2013
73. Uniaxial Strain Effects on Superconducting Transition in Y0.98Ca0.02Ba2Cu4O8
- Author
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Hiroyuki Deguchi, Kaname Matsumoto, Masaki Mito, Hideaki Matsui, Hiroki Goto, Toshinori Ozaki, Yoshihiko Takano, Hiroyuki Takeya, and Hiroshi Hara
- Subjects
Superconductivity ,Magnetic measurements ,Materials science ,Strain (chemistry) ,Condensed matter physics ,Doping ,Hydrostatic pressure ,General Physics and Astronomy ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,law.invention ,Stress (mechanics) ,law ,0103 physical sciences ,Superconducting transition temperature ,Hydrostatic equilibrium ,010306 general physics ,0210 nano-technology - Abstract
The effects of uniaxial strain and hydrostatic pressure on Y0.98Ca0.02Ba2Cu4O8 [called Y0.98(Ca0.02)-124] are investigated via AC magnetic measurements under stress corresponding to a pressure of (at most) 20 GPa. Hydrostatic contraction results in the largest enhancement of the superconducting transition temperature (Tc), whose maximum is 99 K, which is slightly lower than the maximum Tc achieved in YBa2Cu4O8 (called Y-124). The Meissner signal disappears at a hydrostatic pressure of approximately 15 GPa. This pressure region representing the Meissner signal is reduced by the out-of-plane contraction (along the c-axis), whereas it is increased by the in-plane contraction (along the c-plane). In the case of Y-124, both uniaxial contractions result in the disappearance of the Meissner signal at approximately 10 GPa prior to reaching the overdoped region. However, by doping Ca into the Y-site, we could investigate uniaxial strain effects characteristic of the so-called 124 structure without causing the stre...
- Published
- 2016
74. [An investigation on prognostic diagnosis and therapeutic effects for peripheral facial nerve palsy]
- Author
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Tasuku, Suzuki, Kenji, Suzuki, Mitsuhiko, Oohata, Hideaki, Matsui, and Hiroshi, Okada
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Male ,Facial Paralysis ,Humans ,Female ,Middle Aged ,Prognosis ,Retrospective Studies - Abstract
Prognostic examinations and therapeutic strategy for peripheral facial nerve palsy are still obscure. We investigated the utility of examinations and the effects of treatment in these patients retrospectively.A total of 301 patients with peripheral facial nerve palsy were classified into three groups: Group A, cured within two months (n = 208), Group B, cured within six months (n = 34), Group C, uncured (n = 59). Patient's characteristics, electrophysiological examinations and treatment methods were compared between the groups.The mean age of patients was higher in Group C than in Group A, and the lowest palsy score was higher in Group A than in another groups (P0.05). Sensitivity and specificity for prognostic diagnosis were higher in electroneurography rather than blink reflex and Yanagihara grading system. Cervical sympathetic nerve block and hyperbaric oxygen therapy did not affect patients' prognosis. There were not significant difference on prognosis between over 120 mg x day(-1) and 60 mg x day(-1) of prednisolone.Lower palsy score and higher age were risks of bad prognosis and electroneurography is useful for prognostic evaluation of peripheral facial nerve palsy. Therapeutic effects of sympathetic nerve block and hyperbaric oxygen were not entirely clarified. Administration dose of prednisolone was thought to be sufficient with 60 mg x day(-1).
- Published
- 2012
75. Study of Magnetic Domain Dynamics Using Nonlinear Magnetic Responses: Magnetic Diagnostics of the Itinerant Magnet MnP
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Hiroyuki Deguchi, Katsuya Inoue, Yusuke Kousaka, K. Tsuruta, Masaki Mito, Y. Nakao, Shinichiro Yano, Hideaki Matsui, Jun-ichiro Kishine, and Jun Akimitsu
- Subjects
Physics ,Magnetization ,Paramagnetism ,Ferromagnetism ,Condensed matter physics ,Magnetic domain ,Magnet ,Demagnetizing field ,General Physics and Astronomy ,Magnetic susceptibility ,Magnetic field - Abstract
The nonlinear and linear magnetic responses to an ac magnetic field H are useful for the study of the magnetic dynamics of both magnetic domains and their constituent spins. In particular, the third-harmonic magnetic response M3ω reflects the dynamics of magnetic domains. Furthermore, by considering the ac magnetic response as a function of H, we can evaluate the degree of magnetic nonlinearity, which is closely related to M3ω. In this study, a series of approaches was used to examine the itinerant magnet MnP, in which both ferromagnetic and helical phases are present. On the basis of this investigation, we systematize the diagnostic approach to evaluating nonlinearity in magnetic responses.
- Published
- 2015
76. Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish
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Hideaki, Matsui, Hidefumi, Ito, Yoshihito, Taniguchi, Shunichi, Takeda, and Ryosuke, Takahashi
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Neurons ,Substantia Nigra ,Disease Models, Animal ,Phenotype ,Parkinsonian Disorders ,Dopamine ,Tunicamycin ,Neurotoxins ,Oryzias ,Animals ,Nerve Tissue Proteins ,Ammonium Chloride ,Acetylcysteine - Abstract
Perturbations in protein folding and degradation are key pathological mechanisms in neurodegenerative diseases, including Parkinson's disease (PD). Recent evidence suggests that mishandling of proteins may play an important role in the pathogenesis of PD. We have utilized medaka fish to monitor the effects of injecting neurotoxins into the CSF space. In this study, ammonium chloride, tunicamycin, and lactacystin were tested for their ability to disturb lysosomal proteolysis, N-glycosylation in the endoplasmic reticulum, and proteasomal degradation, respectively. All of the substances tested induced selective loss of dopaminergic neurons, movement disorders and inclusion bodies. Among them, the features of the inclusion bodies that developed after ammonium chloride injection mimicked those of PD: co-localization of ubiquitin and phosphorylated α-synuclein, as well as the presence of LC3 protein in the inclusion bodies. Our study demonstrated that medaka fish are useful for examining the effects of environmental toxins and lysosome inhibition, and lysosome inhibitors may be factors in the development of PD.
- Published
- 2011
77. Proteasome inhibition in medaka brain induces the features of Parkinson's disease
- Author
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Hideaki, Matsui, Hidefumi, Ito, Yoshihito, Taniguchi, Haruhisa, Inoue, Shunichi, Takeda, and Ryosuke, Takahashi
- Subjects
Brain Chemistry ,Inclusion Bodies ,Neurons ,Dyskinesia, Drug-Induced ,Behavior, Animal ,Dopamine ,Blotting, Western ,Oryzias ,Ubiquitination ,Cysteine Proteinase Inhibitors ,Immunohistochemistry ,Acetylcysteine ,Norepinephrine ,Microscopy, Electron, Transmission ,Sympatholytics ,Animals ,Parkinson Disease, Secondary ,Oxidopamine ,Proteasome Inhibitors ,Swimming - Abstract
Recent findings suggest that a defect in the ubiquitin-proteasome system plays an important role in the pathogenesis of Parkinson's disease (PD). A previous report (McNaught et al. 2004) demonstrated that rats systemically injected with proteasome inhibitors exhibited PD-like clinical symptoms and pathology. However, because these findings have not been consistently replicated, this model is not commonly used to study PD. We used medaka fish to test the effect of systemic administration of proteasome inhibitors because of the high level of accessibility of the cerebrospinal fluid in fish. We injected lactacystin or epoxomicin into the CSF of medaka. With proteasome inhibition in the medaka brain, selective dopaminergic and noradrenergic cell loss was observed. Furthermore, treated fish exhibited reduced spontaneous movement. Treatment with proteasome inhibitors also induced the formation of inclusion bodies resembling Lewy bodies, which are characteristic of PD. Treatment with 6-OHDA also induced dopaminergic cell loss but did not produce inclusion bodies. These findings in medaka are consistent with previous results reporting that non-selective proteasome inhibition replicates the cardinal features of PD: locomotor dysfunction, selective dopaminergic cell loss, and inclusion body formation.
- Published
- 2010
78. ChemInform Abstract: Lauryl and Stearyl Thioglycosides: Preparation and Reactivity of the Glycosyl Donor
- Author
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Hideaki Matsui, Nobuo Sakairi, Norio Nishi, Jun-ichi Furukawa, and Takuro Awano
- Subjects
Chemistry ,Polymer chemistry ,Organic chemistry ,Reactivity (chemistry) ,General Medicine ,Glycosyl donor - Published
- 2010
79. A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish
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Shunichi Takeda, Hideaki Matsui, Kengo Uemura, Haruhisa Inoue, Ryosuke Takahashi, and Yoshihito Taniguchi
- Subjects
medicine.medical_specialty ,Dyskinesia, Drug-Induced ,animal structures ,Parkinson's disease ,Dopamine ,Oryzias ,Substantia nigra ,Biology ,Time ,chemistry.chemical_compound ,Parkinsonian Disorders ,Internal medicine ,Dopaminergic Cell ,medicine ,Neurotoxin ,Animals ,Diencephalon ,reproductive and urinary physiology ,Neurons ,Tyrosine hydroxylase ,General Neuroscience ,MPTP ,fungi ,Dopaminergic ,Age Factors ,Brain ,General Medicine ,medicine.disease ,Substantia Nigra ,Disease Models, Animal ,Endocrinology ,nervous system ,chemistry ,Larva ,embryonic structures ,Nerve Degeneration ,Biomarkers ,medicine.drug - Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease associated with the degeneration of dopaminergic neurons in the substantia nigra. To create a new model of PD, we used medaka (Oryzias latipes), a small teleost that has been used in genetics and environmental biology. We identified tyrosine hydroxylase (TH) immunopositive dopaminergic and noradrenergic fibers and neurons in the medaka brain. Following establishment of a method for counting the number of dopaminergic neurons and an assay for the evaluation of the medaka behavior, we exposed medaka to 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP). The treatment of medaka at the larval stage, but not at adult stage, decreased the number of dopaminergic cells in the diencephalon and reduced spontaneous movement, which is reminiscent of human PD patients and other MPTP-induced animal PD models. Among TH(+) neurons in the medaka brain, only a specific cluster in the paraventricular area of the middle diencephalon was vulnerable to MPTP toxicity. Detailed examinations of medaka transiently exposed to MPTP at the larval stage revealed that the number of dopaminergic cells was not fully recovered at their adult stage. Moreover, the amounts of dopamine persistently decreased in the brain of these MPTP-treated fish. MPTP-treated medaka is valuable for modeling human PD.
- Published
- 2009
80. [Pathological mechanisms of Parkinson's disease]
- Author
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Hideaki, Matsui and Ryosuke, Takahashi
- Subjects
Neurons ,Substantia Nigra ,Oxidative Stress ,Proteasome Endopeptidase Complex ,Ubiquitin ,Dopamine ,Ubiquitin-Protein Ligases ,alpha-Synuclein ,Animals ,Humans ,Parkinson Disease ,Protein Kinases ,Mitochondria - Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease. It is associated with the degeneration of dopaminergic neurons in the substantia nigra pars compacta and other areas of the brain. The pathology of PD is characterized by the accumulation of a cytoplasmic fibrillar structure, wherein alpha-synuclein is the major component. Most occurrences of PD were believed to be sporadic and associated with aging and environmental stress. However, there is now strong evidence for genetic inheritance in a small number of families. Although the pathological mechanisms of PD are still largely unknown, we present the major hypotheses and discuss the future directions of studies in this area.
- Published
- 2009
81. Dementia in Parkinson's disease: diffusion tensor imaging
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Hideaki Matsui, Fukashi Udaka, Tamotsu Kubori, Masaya Oda, Kazuto Nishinaka, and Hidekazu Niikawa
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Parkinson's disease ,Neuropsychological Tests ,Gastroenterology ,Gyrus Cinguli ,Central nervous system disease ,Degenerative disease ,Cognition ,Internal medicine ,mental disorders ,Fractional anisotropy ,medicine ,Dementia ,Humans ,Pathological ,Aged ,Aged, 80 and over ,Parkinson Disease ,General Medicine ,medicine.disease ,nervous system diseases ,Diffusion Magnetic Resonance Imaging ,Neurology ,Posterior cingulate ,Case-Control Studies ,Anisotropy ,Female ,Neurology (clinical) ,Psychology ,Diffusion MRI - Abstract
Objective – Dementia occurs frequently in patients with Parkinson’s disease (PD). However, the nature of the dementing process remains controversial. We evaluated various cognitive functions in patients with PD, compared fractional anisotropy (FA) values between PD patients with and without dementia. Methods – Thirty-seven consecutive patients with Hoehn-Yahr stage III or IV PD participated in this study. Patients were divided into two groups: (i) PD with dementia group (PDD) and (ii) PD without dementia group (PDND). There were 11 PDD and 26 PDND cases. Ten controls were also studied. Results – The PDD group showed significant FA reduction in the bilateral posterior cingulate bundles compared with PDND. FA values in the left posterior cingulate bundle showed significant correlations with many cognitive parameters. Interpretation – Our results showed that the posterior cingulate areas play some important roles in the dementing process in PDD. However, as the pathological processes responsible for dementia in PD patients may be multifaceted, further studies are necessary.
- Published
- 2007
82. Wisconsin Card Sorting Test in Parkinson's disease: diffusion tensor imaging
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Kenichi Komatsu, Hidekazu Niikawa, Fukashi Udaka, Kazuto Nishinaka, Masaya Oda, Tamotsu Kubori, and Hideaki Matsui
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,Trail Making Test ,Audiology ,Neuropsychological Tests ,Nerve Fibers, Myelinated ,Functional Laterality ,Thinking ,Wisconsin Card Sorting Test ,Memory ,Parietal Lobe ,Basal ganglia ,Fractional anisotropy ,Neural Pathways ,medicine ,Humans ,Attention ,Aged ,Parietal lobe ,Brain ,Parkinson Disease ,General Medicine ,medicine.disease ,Frontal Lobe ,Diffusion Magnetic Resonance Imaging ,Neurology ,Frontal lobe ,Anisotropy ,Female ,Neurology (clinical) ,Psychology ,Cognition Disorders ,Neuroscience ,Executive dysfunction - Abstract
Introduction – It is generally assumed that executive dysfunctions in Parkinson's disease (PD) are caused by degeneration of the basal ganglia or frontal cortex or both. However, there have been few studies investigating the relationship between executive dysfunctions and cerebral pathological change. The objective of this study was to evaluate various cognitive functions in non-demented patients with PD, and to compare the fractional anisotropy (FA) values of PD patients with and without executive dysfunction. Materials and Methods – Twenty-one consecutive non-demented patients with PD were enrolled in this study. Patients were divided into two groups on the basis of their Wisconsin Card Sorting Test score. Results – There was significant FA reduction in the left parietal white matter in the group in which the number of categories achieved was ≤2 relative to the group that achieved >2. Conclusion – Accumulating evidence suggests that conventional ‘frontal’ tasks correlate with both frontal lobe and parietal lobe function, and we suggest that pathological changes in the left parietal lobe may cause, in part, disturbances in executive tasks in PD.
- Published
- 2007
83. Trousseau syndrome due to pleural mesothelioma
- Author
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Fukashi Udaka, Masaya Oda, Hideaki Matsui, Kazuto Nishinaka, and Tamotsu Kubori
- Subjects
Brain Infarction ,Mesothelioma ,Venous Thrombosis ,Pathology ,medicine.medical_specialty ,Pleural mesothelioma ,business.industry ,Pleural Neoplasms ,Disease progression ,General Medicine ,medicine.disease ,Thrombosis ,Magnetic Resonance Imaging ,respiratory tract diseases ,Brain infarction ,Disease Progression ,Medicine ,Humans ,In patient ,Female ,Neurology (clinical) ,business ,Aged - Abstract
Thrombosis involving a brain infarction frequently occurs in patients with a malignant tumor. Although nearly all types of tumor have been reported in association with a hypercoagulable state, pleural mesothelioma-associated Trousseau syndrome is extremely rare.A 69-year-old female was admitted to our hospital with cough, sputum, and breathing difficulties. She was diagnosed as having a mesothelioma from a percutaneous pleural biopsy. Although there were no risk factors for atherosclerosis, brain infarctions showed frequent relapses, even under anticoagulant therapy, and there was a marked hypercoagulable state.Attention should be paid to this syndrome when unexplained brain infarctions occur in patients with pleural mesothelioma.
- Published
- 2007
84. Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein
- Author
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Satoshi Ansai, Yasuo Uchiyama, Kiyoshi Naruse, Shunichi Takeda, Ryosuke Takahashi, Masato Kinoshita, Hideaki Matsui, Takeshi Todo, Norihito Uemura, Hodaka Yamakado, Naoaki Sakamoto, Tomoko Ishikawa-Fujiwara, and Masato Koike
- Subjects
Cancer Research ,medicine.medical_specialty ,Parkinson's disease ,lcsh:QH426-470 ,Oryzias ,Biology ,Pathogenesis ,chemistry.chemical_compound ,Phagosomes ,Internal medicine ,Genetics ,Lysosomal storage disease ,medicine ,Animals ,Molecular Biology ,Genetics (clinical) ,Ecology, Evolution, Behavior and Systematics ,Neuroinflammation ,Alpha-synuclein ,Gaucher Disease ,medicine.disease ,Molecular biology ,Axons ,Glucosylceramidase ,Disease Models, Animal ,lcsh:Genetics ,Endocrinology ,Gaucher's disease ,nervous system ,chemistry ,alpha-Synuclein ,Glucocerebrosidase ,Research Article - Abstract
Homozygous mutations in the glucocerebrosidase (GBA) gene result in Gaucher disease (GD), the most common lysosomal storage disease. Recent genetic studies have revealed that GBA mutations confer a strong risk for sporadic Parkinson’s disease (PD). To investigate how GBA mutations cause PD, we generated GBA nonsense mutant (GBA-/-) medaka that are completely deficient in glucocerebrosidase (GCase) activity. In contrast to the perinatal death in humans and mice lacking GCase activity, GBA-/- medaka survived for months, enabling analysis of the pathological progression. GBA-/- medaka displayed the pathological phenotypes resembling human neuronopathic GD including infiltration of Gaucher cell-like cells into the brains, progressive neuronal loss, and microgliosis. Detailed pathological findings represented lysosomal abnormalities in neurons and alpha-synuclein (α-syn) accumulation in axonal swellings containing autophagosomes. Unexpectedly, disruption of α-syn did not improve the life span, formation of axonal swellings, neuronal loss, or neuroinflammation in GBA-/- medaka. Taken together, the present study revealed GBA-/- medaka as a novel neuronopathic GD model, the pahological mechanisms of α-syn accumulation caused by GCase deficiency, and the minimal contribution of α-syn to the pathogenesis of neuronopathic GD., Author Summary Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal accumulation of alpha-synuclein (α-syn) called Lewy bodies and Lewy neurites. Recent genetic studies have revealed that mutations in glucocerebrosidase (GBA), a causative gene of Gaucher disease (GD), are a strong risk for PD. However, its pathological mechanisms leading to PD remain largely unknown. Here, we generated GBA nonsense mutant (GBA -/-) medaka which survive long enough for pathological analysis of disease progression. These mutant medaka display not only the phenotypes resembling human neuronopathic GD but also axonal accumulation of α-syn accompanied by impairment of the autophagy-lysosome pathway. Furthermore, the present study demonstrates this α-syn accumulation has negligible contribution to the pathogenesis of neuronopathic GD in medaka. GBA -/- medaka represent a valuable model for exploring the pathological mechanisms of PD with GBA mutations as well as neuronopathic GD, and our findings have important implications for the association of GBA mutations with PD.
- Published
- 2015
85. Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations
- Author
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Kenichi Komatsu, Kazuto Nishinaka, Narihiro Hara, Fukashi Udaka, Hideaki Matsui, Tamotsu Kubori, and Masaya Oda
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,genetic structures ,Hallucinations ,Prefrontal Cortex ,Audiology ,Severity of Illness Index ,Central nervous system disease ,Nonverbal communication ,Superior temporal gyrus ,Degenerative disease ,Imaging, Three-Dimensional ,medicine ,Humans ,Prefrontal cortex ,Aged ,Aged, 80 and over ,Auditory Cortex ,Tomography, Emission-Computed, Single-Photon ,Auditory hallucination ,Parkinson Disease ,medicine.disease ,Iofetamine ,eye diseases ,Visual Hallucination ,Neurology ,Female ,Neurology (clinical) ,medicine.symptom ,Radiopharmaceuticals ,Psychology ,Mental Status Schedule ,Neuroscience - Abstract
We examined patients with and without auditory hallucinations, using n-isopropyl-p-[123I]iodoamphetamine single photon emission computed tomographic imaging. We assessed verbal hallucinations in the present study: patients with nonverbal auditory hallucinations were excluded. A total of 11 patients with verbal and visual hallucinations and 17 patients with visual hallucinations only were enrolled. Patients with both verbal and visual hallucinations revealed significant hypoperfusion in the bilateral prefrontal cortex and right superior temporal gyrus compared to patients with visual hallucinations only. There were no significant hyperperfusion in patients with verbal plus visual hallucinations. These results may support the release hallucination theory in verbal hallucinations of Parkinson's disease, although another explanations may be more appropriate and further studies are required.
- Published
- 2006
86. Excessive daytime sleepiness in Parkinson disease: a SPECT study
- Author
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Kazuto Nishinaka, Fukashi Udaka, Kenichi Komatsu, Narihiro Hara, Masaya Oda, Tamotsu Kubori, and Hideaki Matsui
- Subjects
Male ,medicine.medical_specialty ,Polysomnography ,Excessive daytime sleepiness ,Perfusion scanning ,Disorders of Excessive Somnolence ,Severity of Illness Index ,Central nervous system disease ,Degenerative disease ,Physiology (medical) ,Internal medicine ,Surveys and Questionnaires ,medicine ,Humans ,Aged ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,Epworth Sleepiness Scale ,Parkinson Disease ,medicine.disease ,Surgery ,Circadian Rhythm ,Cerebral blood flow ,Cerebrovascular Circulation ,Cardiology ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Somnolence ,Brain Stem - Abstract
STUDY OBJECTIVES The underlying pathologic mechanism of excessive daytime sleepiness (EDS) in Parkinson disease and the relative contributions of brain function to this process are poorly understood. We compared brain perfusion images between patients with Parkinson disease and EDS and those without EDS using n-isopropyl-p-1231 iodoamphetamine single photon emission computed tomography. DESIGN Clinical study. SETTING Sumitomo Hospital. PATIENTS Thirteen patients with Parkinson disease with EDS (EDS group) and 27 patients with Parkinson disease without EDS (no-EDS group) were studied. Whether or not each case had EDS was determined according to the response to the Epworth Sleepiness Scale: patients with an Epworth Sleepiness Scale score > or = 10 were included in the EDS group, and patients with an Epworth Sleepiness Scale score < or = 9 were included in the no-EDS group. MEASUREMENTS AND RESULTS There were significant hypoperfusions in the left parietal and temporal association cortex in the EDS group. In the multivariable logistic regression model, attention and decreased regional cerebral blood flow of the left parietal association cortex and right caudate and increased regional cerebral blood flow of the right thalamus were the independent and significant factors. CONCLUSIONS The cortical hypofunction relative to hyperfunction of the brain stem may relate to EDS in Parkinson disease. This is the first imaging study about EDS in Parkinson disease, and further studies are required.
- Published
- 2006
87. Heterogeneous factors in dementia with Parkinson's disease: IMP-SPECT study
- Author
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Kazuto Nishinaka, Kenichi Komatsu, Masaya Oda, Tamotsu Kubori, Narihiro Hara, Fukashi Udaka, and Hideaki Matsui
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,Disease ,behavioral disciplines and activities ,Severity of Illness Index ,Imaging, Three-Dimensional ,Inosine Monophosphate ,Internal medicine ,Cortex (anatomy) ,mental disorders ,medicine ,Dementia ,Humans ,Stage (cooking) ,Aged ,Aged, 80 and over ,Cerebral Cortex ,Tomography, Emission-Computed, Single-Photon ,Lewy body ,business.industry ,Parkinson Disease ,medicine.disease ,nervous system diseases ,medicine.anatomical_structure ,Neurology ,Cerebral blood flow ,Cerebrovascular Circulation ,Cardiology ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Mental Status Schedule ,Perfusion - Abstract
Background Nature of the dementing process in Parkinson's disease, and particularly its relationship with Alzheimer's disease, diffuse Lewy body disease or frontal dementia remains controversial. Objective We hypothesize that origins of dementia in Parkinson's disease are heterogeneous, so we compared cortical regional cerebral blood flow (rCBF) between Parkinson's disease patients with and without dementia. Patients Forty consecutive patients with Hoehn-Yahr stage III or IV Parkinson's disease were used (13 patients had dementia (PDD group), and 27 patients had no dementia (PDND group)). Results There were significant rCBF reductions in the left parietal association cortex and left frontal association cortex in PDD. Multiple logistic regression analysis demonstrated that only rCBF of the left frontal association cortex was significant. PDD patients were divided into three groups according to rCBF patterns: frontal hypoperfusion group, Alzheimer's disease-like group, and diffuse Lewy body disease-like group. Conclusions Controversial study results involving PDD patients may be mainly due to heterogeneity in dementing processes in Parkinson's disease.
- Published
- 2006
88. Minor depression and brain perfusion images in Parkinson's disease
- Author
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Tamotsu Kubori, Hideaki Matsui, Kazuto Nishinaka, Kenichi Komatsu, Masaya Oda, and Fukashi Udaka
- Subjects
medicine.medical_specialty ,Parkinson's disease ,Central nervous system ,Inferior frontal gyrus ,Perfusion scanning ,Brain mapping ,Sensitivity and Specificity ,Functional Laterality ,Central nervous system disease ,Degenerative disease ,Internal medicine ,medicine ,Humans ,Depression (differential diagnoses) ,Aged ,Brain Mapping ,Brain ,Reproducibility of Results ,Parkinson Disease ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,nervous system diseases ,Surgery ,medicine.anatomical_structure ,Neurology ,Cardiology ,Neurology (clinical) ,Psychology - Abstract
Depression is common in individuals with Parkinson's disease. However, the pathophysiology of depression in Parkinson's disease remains obscure. Here we compared brain perfusion images of Parkinson's disease patients with and without depression to investigate correlations between depression and brain perfusion images in Parkinson's disease. We divided 40 consecutive patients with Parkinson's disease into two groups: patients with minor depression (n = 22) and patients without depression (n = 18). We then compared brain perfusion images between the two groups. As a result, hypoperfusion of the left superior and inferior frontal gyrus was demonstrated in depressed patients. These results were partially in agreement with previous studies on de novo and parkinsonian major depression. We could not conclude on whether pathophysiological mechanisms differed between de novo depression and depression with Parkinson's disease, and between major and minor depressions.
- Published
- 2006
89. Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease
- Author
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Kazuto Nishinaka, Hideaki Matsui, Fukashi Udaka, Masakuni Kameyama, Masaya Oda, and Tamotsu Kubori
- Subjects
Pathology ,medicine.medical_specialty ,Encephalopathy ,Connective tissue ,Functional Laterality ,Mixed connective tissue disease ,Synovitis ,medicine ,Dementia ,Humans ,Cognitive decline ,Connective Tissue Diseases ,Vasculitis, Central Nervous System ,Aged ,Brain Diseases ,business.industry ,medicine.disease ,Dermatology ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Neurology ,Female ,Neurology (clinical) ,Nervous System Diseases ,business ,Vasculitis ,Systemic vasculitis - Abstract
We described a 69-year-old woman with neurological manifestations due to mixed connective tissue disease (MCTD). The patient demonstrated subacute cognitive decline, seizure and gait disturbance with no connective tissue manifestation. She had been diagnosed with dementia at another hospital, later in our hospital, serological examinations disclosed high titers of anti-RNP antibody. Cognitive dysfunction in this patient was dramatically ameliorated by steroid therapy. Three months later, she developed edema of the hands, synovitis and acrosclerosis. The patient was finally diagnosed as having MCTD. We emphasized MCTD as a rare cause of "treatable dementia".
- Published
- 2006
90. HTLV-I-associated peripheral neuropathy with smoldering-type adult T-cell leukemia
- Author
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Kazuto Nishinaka, Hideaki Matsui, Nobuyuki Oka, Masaya Oda, Fukashi Udaka, and Tamotsu Kubori
- Subjects
Pathology ,medicine.medical_specialty ,T-cell leukemia ,Neural Conduction ,Sural Nerve ,hemic and lymphatic diseases ,medicine ,Humans ,Leukemia-Lymphoma, Adult T-Cell ,Aged ,Skin ,Neurologic Examination ,Nerve biopsy ,medicine.diagnostic_test ,business.industry ,Muscle weakness ,Peripheral Nervous System Diseases ,General Medicine ,medicine.disease ,Spinal cord ,Evoked Potentials, Motor ,Lymphoma ,Leukemia ,Peripheral neuropathy ,medicine.anatomical_structure ,Erythema ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Vasculitis - Abstract
Background Peripheral neuropathy with adult T-cell leukemia/lymphoma (ATLL) has seldom been reported. Review summary A 69-year-old woman with smoldering-type ATLL presented with pain and muscle weakness of the bilateral upper and lower limbs and gait disturbance. Anti-human T lymphotropic virus type I antibody was positive in the serum but negative in the cerebrospinal fluid. Magnetic resonance imaging (MRI) showed no abnormal signals in the spinal cord or brain. Nerve conduction studies disclosed severe peripheral neuropathy. Sural nerve biopsy disclosed both axonal degeneration and demyelinated fibers, and marked perivascular inflammatory infiltrates mainly consisting of T lymphocytes without malignant changes were seen. Steroid therapy was markedly effective, and the patient became able to walk without assistance. Conclusions This is the first reported case of ATLL and peripheral neuropathy in which a nerve biopsy was performed. In our patient, the marked perivascular inflammatory infiltrates mainly consisting of T lymphocytes suggested either immune-mediated vasculitis or tumor invasion. Further studies are needed.
- Published
- 2006
91. Frontal assessment battery and brain perfusion image in Parkinson's disease
- Author
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Akiko Tamura, Narihiro Hara, Kazuto Nishinaka, Takafumi Miyoshi, Tamotsu Kubori, Fukashi Udaka, Masaya Oda, Hideaki Matsui, and Masakuni Kameyama
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,Perfusion scanning ,Single-photon emission computed tomography ,Neuropsychological Tests ,050105 experimental psychology ,Brain Ischemia ,Central nervous system disease ,Iodine Radioisotopes ,03 medical and health sciences ,0302 clinical medicine ,Degenerative disease ,Imaging, Three-Dimensional ,Parietal Lobe ,medicine ,Image Processing, Computer-Assisted ,Humans ,0501 psychology and cognitive sciences ,Dominance, Cerebral ,Aged ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,05 social sciences ,Parietal lobe ,Brain ,Parkinson Disease ,Middle Aged ,medicine.disease ,Iofetamine ,Surgery ,Frontal Lobe ,Psychiatry and Mental health ,Frontal lobe ,Regional Blood Flow ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Nuclear medicine ,business ,Psychology ,Cognition Disorders ,Perfusion ,030217 neurology & neurosurgery ,Blood Flow Velocity - Abstract
The objective was to compare brain perfusion image using 3-dimensional stereotactic surface projection analysis of N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography between Parkinson’s disease patients with a high frontal assessment battery score and those with a low frontal assessment battery score. Thirty nondemented patients with Parkinson’s disease were studied. Patients were divided into 2 groups: a high-scoring group whose frontal assessment battery score was 12 or more and a low-scoring group whose frontal assessment battery score was 11 or less. The high-scoring group included 21 patients, and the low-scoring group included 9 patients. They underwent N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography, and we analyzed the data by the 3-dimensional stereotactic surface projection method. Results showed that left inferior parietal lobule and left supramarginal gyrus perfusion of the low-scoring group were significantly decreased compared with the high-scoring group. It is concluded that_patients with Parkinson’s disease may have frontal lobe dysfunction, but the decreased frontal assessment battery score may be caused not by progressed frontal lobe dysfunction but by parietal lobe dysfunction added to their preexisting frontal lobe impairment.
- Published
- 2006
92. Extraction Method for Design Principle of Static Behavior of Vehicle Suspension System
- Author
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Kenzo Miyajima, Hideaki Matsui, and Qiang Yu
- Subjects
Engineering ,business.industry ,GRASP ,Mechanical engineering ,CAD ,Rigidity (psychology) ,computer.software_genre ,Industrial engineering ,Computer Aided Design ,Probabilistic design ,Computer-aided engineering ,business ,Set (psychology) ,computer ,Design technology - Abstract
In recent years, the demand for making a car comfortable is increasing and as a factor which governs the comfort of a car, improvement in the driving-stability is attempted. Although body rigidity, tire characteristic, aerodynamics, etc. are raised as factors affecting the design results, it is known experientially that the influence of a suspension is especially great. Therefore, the design of a suspension system becomes important for making a comfortable car. Generally, the design processes of a complicated system can be finished through three major stages, the concept design, the basic design, and the detailed design. For example, at the stage of detailed design, the design engineers have the CAD data for the manufacture, and at the same time they can develop very accurate computer simulation model from the CAD data to help them to make decision for special design factors. The basic concept of every CAE tool is to generate the analytical model by a series of discrete elements set instead of the physical parts. As a result, it becomes very difficult for the engineers to find the physical mechanism of the complicated behavior of their design from the results of numerical analysis. For the concept design processes, it is very important for the design engineers to understand the basic principle of their basic design plans and to compare with the different concepts to know which one has the highest potential to achieve the design aims. However the engineers have to accomplish these processes by only their experience. In this study, the authors proposed a new method to identify the important information which links to the basic principle of the physical behavior by using CAE technology. This method can help the engineers to grasp the basic physical characteristic that governs the first-order behavior.
- Published
- 2006
93. Biferrocene-M(mnt)2 charge-transfer complexes (M = Ni, Co; mnt = maleonitriledithiolate). structure, valence states, and magnetic properties
- Author
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Masashi Takahashi, Michiko Sato, Hatsumi Mori, Tomoyuki Mochida, M. Takeda, Kousuke Takazawa, Hideaki Matsui, Koji Kajita, and Yutaka Nishio
- Subjects
Inorganic Chemistry ,Crystallography ,Valence (chemistry) ,Chemistry ,Stereochemistry ,Mössbauer spectroscopy ,Crystal structure ,Physical and Theoretical Chemistry ,Isopropyl - Abstract
Charge-transfer salts of branched-alkyl biferrocenes, (1',1' ''-R2-1,1' '-biferrocene)[Ni(mnt)2] (1a, R = isopropyl; 2a, R = dineopentyl) and (1',1' ''-R2-1,1' '-biferrocene)2[Co(mnt)2]2 (1b, R = isopropyl; 2b, R = dineopentyl), were prepared. Their valence states were investigated using X-ray crystallography and Mössbauer spectroscopy. Complexes 1a and 1b show segregated-stack crystal structures that contain columns of acceptors, whereas structures of 2a and 2b, which contain bulky donors, are rather discrete. All of the complexes contain mixed-valent biferrocenium monocations. A two-step valence transition was found in complex 1a. The crystal contains two crystallographically independent cations: one undergoes valence localization below room temperature; the other undergoes valence localization below ca. 130 K. The former transition is derived from asymmetry of the crystal environment around the cation, whereas the latter one is caused by symmetry lowering coupled with a spin-Peierls transition (T(C) = 133.2 K) associated with the dimerization of the acceptors. This compound was found to exhibit a dielectric response based on valence tautomerization. Other complexes (1b, 2a, and 2b) show a valence-trapped state. In all complexes, charge localization was found to occur through local electrostatic interactions between the donor's cationic moiety and the acceptor's electronegative moieties.
- Published
- 2005
94. Does cardiac metaiodobenzylguanidine (MIBG) uptake in Parkinson's disease correlate with major autonomic symptoms?
- Author
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Masaya Oda, Fukashi Udaka, Kazuto Nishinaka, Hideaki Matsui, Tamotsu Kubori, and Kenichi Komatsu
- Subjects
Male ,medicine.medical_specialty ,Levodopa ,Parkinson's disease ,Constipation ,Disease ,Scintigraphy ,Orthostatic vital signs ,Disability Evaluation ,Hypotension, Orthostatic ,Internal medicine ,Medicine ,Humans ,Stage (cooking) ,Radionuclide Imaging ,Aged ,medicine.diagnostic_test ,business.industry ,Urinary Bladder Diseases ,Heart ,Parkinson Disease ,medicine.disease ,nervous system diseases ,Autonomic nervous system ,3-Iodobenzylguanidine ,Endocrinology ,Neurology ,Autonomic Nervous System Diseases ,Data Interpretation, Statistical ,Cardiology ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,medicine.symptom ,Radiopharmaceuticals ,business ,medicine.drug - Abstract
Objectives To compare MIBG (metaiodobenzylguanidine) uptake between Parkinson's disease patients with and without autonomic symptoms to investigate meanings of MIBG scintigraphy and correlations between autonomic symptoms and MIBG uptake. Methods Forty consecutive patients with Hoehn–Yahr III or IV Parkinson's disease and 12 controls were enrolled. We compared cardiac MIBG uptake between patients with and without orthostatic hypotension. Similar comparisons were performed for constipation and bladder dysfunction. Results MIBG uptake did not significantly correlate with age, disease duration, Hoehn–Yahr stage, Unified Parkinson's Disease Rating Scale (UPDRS) motor score or levodopa equivalent daily doses. There were no significant correlations between orthostatic hypotension/constipation and cardiac MIBG uptake. Only bladder symptoms significantly correlated with MIBG uptake. Conclusion Meanings of MIBG uptake abnormalities in Parkinson's disease and relationship between MIBG uptake and clinical parameters remain to be resolved in future studies.
- Published
- 2005
95. Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease
- Author
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Kazuto Nishinaka, Akiko Tamaura, Fukashi Udaka, Hideaki Matsui, Tamotsu Kubori, Takafumi Miyoshi, Masaya Oda, Narihiro Hara, and Masakuni Kameyama
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,Brodmann area 11 ,Prefrontal Cortex ,Perfusion scanning ,Severity of Illness Index ,Central nervous system disease ,Physical medicine and rehabilitation ,Gait (human) ,Degenerative disease ,Imaging, Three-Dimensional ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Gait ,Aged ,Tomography, Emission-Computed, Single-Photon ,Movement Disorders ,Gait Disturbance ,Brain ,Parkinson Disease ,medicine.disease ,Iofetamine ,nervous system diseases ,Neurology ,Case-Control Studies ,Cerebrovascular Circulation ,Orbitofrontal cortex ,Female ,Neurology (clinical) ,Radiopharmaceuticals ,Psychology ,human activities ,Neuroscience - Abstract
Gait disturbance is a cardinal symptom in patients with Parkinson's disease. Among the gait disturbances, freezing of gait is a unique and troublesome symptom, but its mechanism is unclear. We compared brain perfusion images using three-dimensional stereotactic surface projection analysis of N-isopropyl-p-123I iodoamphetamine single photon emission computed tomography between Parkinson's disease patients with freezing of gait and those without. Twenty-four cases (freezing of gait group) with Parkinson's disease with freezing of gait, and 31 Hoehn and Yahr stage-matched cases (no freezing of gait group) with Parkinson's disease without freezing of gait were studied. Bilateral Brodmann area 11 perfusion of the freezing of gait group decreased significantly compared to that of the no freezing of gait group. The Brodmann area 11 may play important roles in gait, and impairment in this region may have a close relationship with freezing of gait in Parkinson's disease. © 2005 Movement Disorder Society
- Published
- 2005
96. Metaiodobenzylguanidine (MIBG) scintigraphy at various parts of the body in Parkinson's disease and multiple system atrophy
- Author
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Kazuto Nishinaka, Tamotsu Kubori, Fukashi Udaka, Masakuni Kameyama, Hideaki Matsui, and Masaya Oda
- Subjects
Male ,medicine.medical_specialty ,Sympathetic nervous system ,Parkinson's disease ,Thyroid Gland ,Disease ,Scintigraphy ,Central nervous system disease ,Cellular and Molecular Neuroscience ,Atrophy ,Degenerative disease ,Internal medicine ,medicine ,Humans ,Radionuclide Imaging ,Lung ,Aged ,medicine.diagnostic_test ,Endocrine and Autonomic Systems ,business.industry ,Parkinson Disease ,Middle Aged ,Multiple System Atrophy ,medicine.disease ,Autonomic nervous system ,3-Iodobenzylguanidine ,Endocrinology ,medicine.anatomical_structure ,Liver ,Cardiology ,Female ,Neurology (clinical) ,business - Abstract
We compared MIBG uptake at various parts of the body in controls and patients with Parkinson's disease and multiple system atrophy. In the heart, MIBG uptake in Parkinson's disease (early H/M: 1.668+/-0.325, late H/M: 1.500+/-0.402) was less than that in multiple system atrophy (early H/M: 2.395+/-0.186, late H/M: 2.530+/-0.391) and controls (early H/M: 2.635+/-0.508, late H/M: 2.575+/-0.635) (early: P0.0001, late: P0.0001). There were no significant differences in uptake by the lung, thyroid, or liver in the three groups. Only on early images, uptake in the shoulder in multiple system atrophy (early S/M: 0.473+/-0.78) and Parkinson's disease (early S/M: 0.470+/-0.710) was decreased compared to that in controls (early S/M: 0.560+/-0.118) (P=0.0252). MIBG is reported to be taken up in the terminal part of sympathetic nerves and demonstrates sympathetic nerve activity, especially on late images. The cause of differences between the heart and other parts of the body remains unknown. We consider the following possibilities: (a) differences in the sympathetic nervous system between Parkinson's disease and multiple system atrophy are more subtle in organs other than the heart; (b) the cause of MIBG uptake reduction by the heart in Parkinson's disease involves factors in addition to sympathetic nervous system damage; and (c) MIBG uptake by organs other than the heart involves not only the sympathetic nervous system but also non-neuronal components. In conclusion, MIBG uptake by organs other than the heart cannot differentiate Parkinson's disease from multiple system atrophy at present.
- Published
- 2004
97. Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features
- Author
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Hideaki Matsui, Kazuto Nishinaka, Fukashi Udaka, Akiko Tamura, Narihiro Hara, Tamotsu Kubori, Masakuni Kameyama, Masaya Oda, and Takafumi Miyoshi
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Cerebellum ,Parkinson's disease ,Perfusion scanning ,Scintigraphy ,Diagnosis, Differential ,Iodine Radioisotopes ,Atrophy ,stomatognathic system ,mental disorders ,medicine ,Humans ,Aged ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Putamen ,Parkinson Disease ,Middle Aged ,Multiple System Atrophy ,medicine.disease ,nervous system diseases ,medicine.anatomical_structure ,nervous system ,Neurology ,Cerebral blood flow ,Cerebrovascular Circulation ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Radiopharmaceuticals ,business ,Perfusion - Abstract
Background The patterns of regional cerebral blood flow in Parkinson's disease and multiple system atrophy remain inconsistent. Objectives To compare brain perfusion images of 123 I-IMP SPECT between Parkinson's disease, multiple system atrophy with predominant parkinsonian features (MSA-P) and controls. Methods Eighty-two patients with Parkinson's disease, 10 patients with MSA-P and 14 controls were studied. We performed 3D-SSP and volume of interest analysis using 123 I-IMP scintigraphy. Results Occipital perfusion of MSA-P increased compared to that of Parkinson's disease and perfusion in the cerebellum and primary sensorimotor cortex of Parkinson's disease increased compared to that of MSA-P. Perfusion in the putamen of MSA-P decreased compared to that of Parkinson's disease. Conclusion Our study demonstrated perfusion differences in 123 I-IMP SPECT between the two diseases.
- Published
- 2004
98. [Two cases of Parkinson's disease in which visual hallucinations disappeared after cataract surgery]
- Author
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Hideaki, Matsui, Fukashi, Udaka, Masaya, Oda, Tamotsu, Kubori, Kazuto, Nishinaka, and Masakuni, Kameyama
- Subjects
Antiparkinson Agents ,Levodopa ,Hallucinations ,Remission Induction ,Visual Perception ,Humans ,Female ,Parkinson Disease ,Cataract Extraction ,Risperidone ,Bromocriptine ,Aged - Abstract
We report two cases of Parkinson's disease in which visual hallucinations disappeared after cataract surgery. Patient 1 was a 72-year-old woman with Parkinson's disease, visual hallucinations and musical hallucinations. Patient 2 was a 77-year-old woman with Parkinson's disease and visual hallucinations. Both patients had severe bilateral cataracts. Though it was difficult to control their visual hallucinations with medication only, cataract surgery made them disappeared quickly. The visual hallucinations of Parkinson's disease are similar to those of Charles Bonnet syndrome. For example, both hallucinations often happen in dim light, at night and when patients are awake with eyes open. Though there have been many reports describing visual hallucinations in Parkinson's disease, there have been few reports discussing the relation between these hallucinations and impaired visual acuity. Similar to the hallucinations of Charles Bonnet syndrome, impaired visual acuity should be related to the visual hallucinations of Parkinson's disease. When Parkinson's disease, visual hallucinations and severe cataract coexist, visual hallucinations may disappear after cataract surgery.
- Published
- 2004
99. Erratum: 'Effects of selective lattice deformation on YbBa2Cu4O8 and YBa2Cu3O7 epitaxial films' [Appl. Phys. Lett. 104, 102601 (2014)]
- Author
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Yutaka Yoshida, Kazuhiko Matsumoto, Hiroyuki Deguchi, Hideaki Matsui, T. Horide, Masaki Mito, Ataru Ichinose, and T. Imakyurei
- Subjects
Lattice deformation ,Materials science ,Physics and Astronomy (miscellaneous) ,Condensed matter physics ,Deformation (meteorology) ,Epitaxy - Published
- 2014
100. Various models for Parkinson's disease using mutant medaka and toxin-treated medaka
- Author
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Shunichi Takeda, Ryosuke Takahashi, Hideaki Matsui, Yoshihito Taniguchi, and Haruhisa Inoue
- Subjects
Parkinson's disease ,Toxin ,General Neuroscience ,Mutant ,medicine ,General Medicine ,Biology ,medicine.disease ,medicine.disease_cause ,Molecular biology - Published
- 2009
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