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52. Corticosteroids in patients hospitalized for COVID-19 pneumonia who require oxygen: observational comparative study using routine care data

Author

Tran, Viet-Thi, primary, Mahévas, Matthieu, additional, Bani-Sadr, Firouze, additional, Robineau, Olivier, additional, Perpoint, Thomas, additional, Perrodeau, Elodie, additional, Gallay, Laure, additional, Ravaud, Philippe, additional, Goehringer, François, additional, Lescure, François-Xavier, additional, Tran, Viet-Thi, additional, Ismaël, Sophie, additional, Laouénan, Cédric, additional, Soulier, Jennifer, additional, Puéchal, Oriane, additional, D’Ortenzio, Eric, additional, Yazdanpanah, Yazdan, additional, Maulin, Laurence, additional, Martinez, Stéphanie, additional, Sanderink, Diane, additional, Fialaire, Pascale, additional, Ansart, Séverine, additional, Perez, Lucas, additional, Destrem, Anne - Laure, additional, Moulin, Chloé, additional, Gicquel, Pascal, additional, Rivière, Frédéric, additional, Martinot, Martin, additional, Zadeh, Mahsa Mohseni, additional, Chroboczek, Tomasz, additional, Belval, Thibaut Challan, additional, Piroth, Lionel, additional, Sixt, Thibault, additional, Moretto, Florian, additional, Cabié, André, additional, Pasquier, Jérémie, additional, Cabras, Ornella, additional, Morrier, Marine, additional, Reuter, Jean, additional, Henin, Thomas, additional, Braquet, Pierre, additional, Desmurs-Clavel, Helene, additional, Hot, Arnaud, additional, Bienvenu, Boris, additional, Asselate, Belkacem, additional, Vignier, Nicolas, additional, Nguala, Steve, additional, Diamantis, Sylvain, additional, Frémont, Guillemette, additional, Nivose, Pierre Louis, additional, Thiébaut, Mathilde, additional, Lefevre, Benjamin, additional, Auge, Hélène, additional, le Turnier, Paul, additional, Benkalfate, Naila, additional, Grossi, Olivier, additional, Pineau, Samuel, additional, Demonchy, Elisa, additional, Merindol, Julie, additional, Durand, Claire, additional, Tieulié, Nathalie, additional, Queyrel, Viviane, additional, Laureillard, Didier, additional, Loubet, Paul, additional, Greffe, Ségolène, additional, Dournon, Nathalie, additional, Kassim, Youssouf Mohamed, additional, Gourjault, Cyrille, additional, Lahens, Alexandre, additional, Legendre, Paul, additional, Morbieu, Caroline, additional, Mahevas, Matthieu, additional, Melica, Giovanna, additional, Levièvre, Jean-Daniel, additional, Schlemmer, Frédéric, additional, Tunesi, Simone, additional, Leblanc, Claire, additional, Bourgarit-Durand, Anne, additional, Bleibtreu, Alexandre, additional, Tebano, Gianpiero, additional, Pacanowski, Jérôme, additional, Zabbe, Jean-Benoit, additional, Devaux, Mathilde, additional, Bellec, Laurent, additional, Gosset-Woimant, Marine, additional, Lambert, Céleste, additional, Hentzien, Maxime, additional, Servettaz, Amélie, additional, Alexandre, Kevin, additional, Etienne, Manuel, additional, Leguillon, Romain, additional, Dollat, Marion, additional, Lefrancois, Rémi, additional, Pouvaret, Anne, additional, Ruch, Yvon, additional, Dieudonné, Yannick, additional, Martin-Blondel, Guillaume, additional, Boumaza, Xavier, additional, Lafaurie, Margaux, additional, Tetart, Macha, additional, Lemaignen, Adrien, additional, Ferreira-Maldent, Nicole, additional, Duréault, Amélie, additional, Gousseff, Marie, additional, Chantepie, Claire, additional, Bisio, Francesca, additional, Pommeret, Fanny, additional, Blamble, Emeline Colomba, additional, and Somohano, Claire Ara, additional

Published
2021
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53. Belatacept-based immunosuppressive regimen in HIV-positive kidney transplant recipients

Author

El Sakhawi, Karim, primary, Melica, Giovanna, additional, Scemla, Anne, additional, Bertrand, Dominique, additional, Garrouste, Cyril, additional, Malvezzi, Paolo, additional, Rémy, Philippe, additional, Moktefi, Anissa, additional, Ingels, Alexandre, additional, Champy, Cécile, additional, Lelièvre, Jean-Daniel, additional, Kheav, David, additional, Morel, Antoine, additional, Mokrani, David, additional, Attias, Philippe, additional, Grimbert, Philippe, additional, and Matignon, Marie, additional

Published
2020
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54. Procalcitonin to Reduce Antibiotic Exposure during Acute Chest Syndrome in Adult Patients with Sickle-Cell Disease

Author

Razazi, Keyvan, primary, Gendreau, Ségolène, additional, Cuquemelle, Elise, additional, Khellaf, Mehdi, additional, Guillaud, Constance, additional, Godeau, Bertrand, additional, Melica, Giovanna, additional, Moutereau, Stéphane, additional, Gomart, Camille, additional, Fourati, Slim, additional, De Prost, Nicolas, additional, Carteaux, Guillaume, additional, Brun-Buisson, Christian, additional, Bartolucci, Pablo, additional, Habibi, Anoosha, additional, and Mekontso Dessap, Armand, additional

Published
2020
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60. Risk factors for intra‐abdominal fungal infection after simultaneous pancreas‐kidney transplantation: A single‐center retrospective experience

Author

Flateau, Clara, primary, Aït‐Ammar, Nawel, additional, Angebault, Cécile, additional, Salomon, Laurent, additional, Matignon, Marie, additional, Lepeule, Raphaël, additional, Melica, Giovanna, additional, Grimbert, Philippe, additional, Lelièvre, Jean‐Daniel, additional, Gallien, Sébastien, additional, and Botterel, Françoise, additional

Published
2020
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63. Cutaneous Macroglobulinosis: A Report of 2 Cases

Author

Gressier, Ludivine, Hotz, Claire, Lelièvre, Jean-Daniel, Carlotti, Agnès, Buffet, Marc, Wolkenstein, Pierre, Bagot, Martine, Melica, Giovanna, and Ortonne, Nicolas

Published
2010

66. Immune Responses after a Third Dose of mRNA Vaccine Differ in Virus-Naive versus SARS-CoV-2? Recovered Dialysis Patients

Author

Attias, Philippe, Azzaoui, Imane, El Karoui, Khalil, de La Selle, Andr?a, Sokal, Aur?lien, Chappert, Pascal, Grimbert, Philippe, Fernandez, Ignacio, Bouvier, Magali, Samson, Chlo?, Dahmane, Djamal, Rieu, Philippe, Nizard, Patrice, Fourati, Slim, Sakhi, Hamza, Mah?vas, Matthieu, Audard, Vincent, Bentaarit, Boutheina, Boueilh, Anna, Gallien, S?bastien, Grimbert, Philippe, Hue, Sophie, Joher, Nizar, Jouan, Narindra, Lamriben, Larbi, Leli?vre, Jean-Daniel, Lepeule, Rapha?l, Mah?vas, Matthieu, Matignon, Marie, Melica, Giovanna, Oniszczuk, Julie, Pawlotsky, Jean-Michel, Stehl?, Thomas, Vindrios, William, and Wemmert, Charlotte

Published
2022
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68. Traitement par monothérapie de cotrimoxazole des nocardioses chez les patients transplantés d’organe solide : résultats d’une étude européenne multicentrique rétrospective

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Conan, Pierre, Van Laecke, Steven, Vuotto, Fanny, Levi, Charlène, Matignon, Marie, Melica, Giovanna, Brenier, Henri, De Greef, Julien, Coussement, Julien, Lebeaux, David, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, Conan, Pierre, Van Laecke, Steven, Vuotto, Fanny, Levi, Charlène, Matignon, Marie, Melica, Giovanna, Brenier, Henri, De Greef, Julien, Coussement, Julien, and Lebeaux, David

Abstract

INTRODUCTION : La nocardiose est une infection opportuniste grave qui touche de 0,04 à 3,5 % des greffés d’organe solide. Le cotrimoxazole (CMZ) en monothérapie semble être une option thérapeutique intéressante, compte tenu de son large spectre anti-Nocardia et de sa bonne diffusion tissulaire. L’objectif de notre étude était de décrire l’expérience clinique du CMZ en monothérapie chez les patients greffés d’organe solides présentant une infection à Nocardia. MATÉRIELS ET MÉTHODES : Nous avons analysé les données d’une étude multinationale rétrospective cas-témoins déjà publiée qui avait inclus 117 cas de nocardiose diagnostiquées entre 2000 et 2014. Tous les patients traités par CMZ dans les 15 jours suivant le diagnostic de nocardiose étaient éligibles, à condition d’avoir eu moins de 5 jours d’association avec d’autres antibiotiques (cohorte A). Parmi eux, la cohorte B comprenait tous les patients ayant reçu plus de 30 jours de CMZ en monothérapie. Pour chaque patient éligible, un questionnaire a été envoyé aux investigateurs pour recueillir des données supplémentaires. RÉSULTATS : Trente patients ont été inclus dans la cohorte A. La plupart présentait une nocardiose pulmonaire/pleurale (n = 25/30, 83 %). Onze patients (36 %) présentaient une nocardiose disséminée ou une atteinte cutanée et 4/30 (13 %) avaient une atteinte cérébrale. Les organes transplantés étaient majoritairement le rein (20/30, 66 %) et le cœur (5/30, 17 %). Nocardia farcinica (11/26, 42 %) était la plus fréquemment retrouvée. Parmi les 19 patients de la cohorte A pour lesquels le formulaire complémentaire a été retourné, : une insuffisance rénale aiguë ou une hyperkaliémie ont été observées chez 12/19 (63 %) et 7/19 (37 %) des patients. Dans 9/19 cas, le CMZ a été interrompu en raison d’une toxicité et un patient était décédé un jour après avoir commencé le CMZ. Chez un patient, le CMZ a été arrêté en raison d’un échec thérapeutique avec aggravation de l’atteinte pulmonaire après 4 mois de mo

Published
2019

69. Belatacept-based immunosuppressive regimen in HIV-positive kidney transplant recipients.

Author

Sakhawi, Karim El, Melica, Giovanna, Scemla, Anne, Bertrand, Dominique, Garrouste, Cyril, Malvezzi, Paolo, Rémy, Philippe, Moktefi, Anissa, Ingels, Alexandre, Champy, Cécile, Lelièvre, Jean-Daniel, Kheav, David, Morel, Antoine, Mokrani, David, Attias, Philippe, Grimbert, Philippe, and Matignon, Marie

Subjects
*GRAFT survival, *KIDNEY transplantation, *SURVIVAL rate, *HIV-positive persons, *HIV
Abstract

Background Kidney allograft survival in human immunodeficiency virus (HIV)-positive patients is lower than that in the general population. Belatacept increases long-term patient and allograft survival rates when compared with calcineurin inhibitors (CNIs). Its use in HIV-positive recipients remains poorly documented. Methods We retrospectively report a French cohort of HIV-positive kidney allograft recipients who were switched from CNI to belatacept, between June 2012 and December 2018. Patient and allograft survival rates, HIV immunovirological and clinical outcomes, acute rejection, opportunistic infections (OIs) and HLA donor-specific antibodies (DSAs) were analysed at 3 and 12 months, and at the end of follow-up (last clinical visit attended after transplantation). Results were compared with HIV-positive recipients group treated with CNI. Results Twelve patients were switched to belatacept 10 (2–25) months after transplantation. One year after belatacept therapy, patient and allograft survival rates scored 92% for both, two (17%) HIV virological rebounds occurred due to antiretroviral therapy non-compliance, and CD4+ and CD8+ T-cell counts remained stable over time. Serious adverse events included two (17%) acute steroid-resistant T-cell-mediated rejections and three (25%) OIs. Kidney allograft function significantly increased over the 12 post-switch months (P = 0.009), and DSAs remained stable at 12 months after treatment. The control group showed similar results in terms of patient and kidney allograft survival rates, DSA characteristics and proteinuria Conclusions Switch from CNI to belatacept can be considered safe and may increase long-term kidney allograft survival in HIV-positive kidney allograft recipients. These results need to be confirmed in a larger cohort. [ABSTRACT FROM AUTHOR]

Published
2021
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70. Epidemiology, Risk Factors, and Outcomes of Opportunistic Infections after Kidney Allograft Transplantation in the Era of Modern Immunosuppression: A Monocentric Cohort Study

Author

Attias, Philippe, primary, Melica, Giovanna, additional, Boutboul, David, additional, De Castro, Nathalie, additional, Audard, Vincent, additional, Stehlé, Thomas, additional, Gaube, Géraldine, additional, Fourati, Slim, additional, Botterel, Françoise, additional, Fihman, Vincent, additional, Audureau, Etienne, additional, Grimbert, Philippe, additional, and Matignon, Marie, additional

Published
2019
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71. Risk factors for intra‐abdominal fungal infection after simultaneous pancreas‐kidney transplantation: A single‐center retrospective experience.

Author

Flateau, Clara, Aït‐Ammar, Nawel, Angebault, Cécile, Salomon, Laurent, Matignon, Marie, Lepeule, Raphaël, Melica, Giovanna, Grimbert, Philippe, Lelièvre, Jean‐Daniel, Gallien, Sébastien, and Botterel, Françoise

Subjects
INTRA-abdominal infections, MYCOSES, ARTERIAL grafts, REOPERATION, CANDIDA albicans, NECROTIZING pancreatitis
Abstract

Background: Data on the risk factors and outcome of intra‐abdominal fungal infections (IAFI) following simultaneous pancreas‐kidney transplantation (PKT) are scarce. Materials/methods: A retrospective monocentric study was conducted on all patients who underwent simultaneous PKT from January 2007 to December 2016. Deep sites positive cultures for fungi during the first post‐transplantation year were collected. Clinical, radiological, and microbiological data of proven and probable invasive fungal infections were analysed. Results: Among sixteen PKT patients, 15 were included. Seven patients (47%) developed an invasive fungal infection, exclusively IAFI (six proven, one probable). The proven IAFI included four peritonitis, one pancreatic necrosis with infected hematoma, and one patient with positive preservation fluid only (PF). Candida albicans (n = 4) was the most prevalent species (associated with Galactomyces candidus in one case), C glabrata, C dubliniensis, and C krusei were found in one case each. Three patients had either a positive direct examination and/or culture for renal or pancreatic PF and the culture of PF was positive for the same species that caused IAFI. IAFIs were significantly associated with pancreatic graft arterial thrombosis (5/7 vs 0/8, P =.007) and fungal contamination of PF (3/7 vs 0/8, P =.008). Among patients with IAFI, all required an early surgical revision post‐transplantation [1‐18 days] and six had early or delayed pancreatic graft removal. One patient died in the first post‐transplant year. Conclusion: IAFI is a common complication in PKT, associated with pancreatic graft thrombosis or fungal contamination of the graft PF, and can sometimes lead to pancreatic detransplantation. [ABSTRACT FROM AUTHOR]

Published
2021
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72. Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study

Author

Lebeaux, David, Freund, Romain, Delden, Christian, Guillot, Hélène, Marbus, Sierk D., Matignon, Marie, Van Wijngaerden, Eric, Douvry, Benoit, De Greef, Julien, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Jacobs, Frédérique, Lortholary, Olivier, Coussement, Julien, Anstey, James R., Antoine, Martine, Ausselet, Nathalie, Belhaj, Asmae, Boelens, Jerina, Beenhouwer, Hans, Denis, Catherine, Ho, Erwin, Ieven, Margareta, Jonckheere, Stijn, Knoop, Christiane, Moine, Alain, Rodriguez-Villalobos, Hector, Racapé, Judith, Roisin, Sandrine, Vandercam, Bernard, Vander Zwalmen, Marie-Laure, Vanfraechem, Gaëlle, Van Laecke, Steven, Verhaegen, Jan, Barrou, Benoit, Battistella, Pascal, Bergeron, Emmanuelle, Bouvier, Nicolas, Caillard, Sophie, Caumes, Eric, Chaussade, Hélène, Chauvet, Cécile, Crochette, Romain, Epailly, Eric, Essig, Marie, Gallien, Sébastien, Guillemain, Romain, Herel, Canan, Hoen, Bruno, Kamar, Nassim, Gall, Thierry, Levi, Charlene, Lionet, Arnaud, Longuet, Hélène, Melica, Giovanna, Miel, Anaick, Morel, Hélène, Ammar, Salima Ould, Pattier, Sabine, Peraldi, Marie-Noelle, Sayegh, Johnny, Scemla, Anne, Senechal, Agathe, Tourret, Jérome, Boggian, Katia, Egli, Adrian, Garzoni, Christian, Hoffman, Matthias, Hirsch, Hans H., Khanna, Nina, Manuel, Oriol, Meylan, Pascal, Mueller, Nicolas J., Posfay-Barbe, Klara M., Vu, Diem-Lan, Weisser, Maja, Vollaard, Albert M., Wunderink, Herman F., Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Lyon (ENVL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL), UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (MGD) Service de chirurgie cardio-vasculaire et thoracique, UCL - (MGD) Service de médecine interne générale, UCL - (SLuc) Service de médecine interne générale, and UCL - (SLuc) Service de microbiologie

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, [SDV]Life Sciences [q-bio], 030106 microbiology, Antibiotics, Improved survival, 610 Medicine & health, Nocardia, 03 medical and health sciences, Internal medicine, medicine, In patient, opportunistic infections, ddc:617, business.industry, Nocardiosis, organ transplantation, Odds ratio, medicine.disease, mortality, Confidence interval, 3. Good health, Surgery, Infectious Diseases, Conditional logistic regression, prognosis, Solid organ transplantation, business
Abstract

Background Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Factors associated with one-year all-cause mortality were identified using multivariable conditional logistic regression. Results One-year mortality was 10-fold higher in patients with nocardiosis (16.2%, 19/117) than in control transplant recipients (1.3%, 3/233, p

Published
2017

73. Kinetics of Anti–SARS-CoV-2 IgG Antibodies in Hemodialysis Patients Six Months after Infection

Author

Sakhi, Hamza, Dahmane, Djamal, Attias, Philippe, Kofman, Thomas, Bouvier, Magali, Lapidus, Nathanael, Fourati, Slim, El Karoui, Khalil, Audard, Vincent, Bentaarit, Boutheina, Boueilh, Anna, Gallien, Sébastien, Grimbert, Philippe, Hüe, Sophie, Joher, Nizar, Jouan, Narindra, Lamriben, Larbi, Lelièvre, Jean-Daniel, Lepeule, Raphaël, Mahévas, Matthieu, Matignon, Marie, Melica, Giovanna, Oniszczuk, Julie, Pawlotsky, Jean-Michel, Stehlé, Thomas, Vindrios, William, and Wemmert, Charlotte

Published
2021
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74. Shift from widespread to tailored antifungal prophylaxis in lymphoma patients treated with CD19 CAR T- cell therapy: results from a large retrospective cohort

Author

Melica, Giovanna, de Abia, Alejandro Luna, Shah, Gunjan L., Devlin, Sean, Corona, Magdalena, Fein, Joshua, Dahi, Parastoo B., Giralt, Sergio A., Lin, Richard J., Palomba, M. Lia, Parascondola, Allison, Park, Jae, Salles, Gilles, Saldia, Amethyst, Scordo, Michael, Shouval, Roni, Perales, Miguel-Angel, and Seo, Susan K.

Abstract

Patients undergoing CD19 chimeric antigen receptor (CAR) T-cell therapy exhibit multiple immune deficits that may increase their susceptibility to infections. Invasive fungal infections (IFI) are life-threatening events in the setting of hematological diseases. However, there is ongoing debate regarding the optimal role and duration of antifungal prophylaxis in this specific patient population.

Published
2024
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75. Nocardia Infection in Solid Organ Transplant Recipients: A Multicenter European Case-control Study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (MGD) Service de chirurgie cardio-vasculaire et thoracique, Coussement, Julien, Lebeaux, David, van Delden, Christian, Guillot, Hélène, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Van Wijngaerden, Eric, Douvry, Benoit, Van Laecke, Steven, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Lortholary, Olivier, Jacobs, Frédérique, European Study Group for Nocardia in Solid Organ Transplantation, Belhaj, Asmae, De Greef, Julien, Rodriguez-Villalobos, Hector, Vandercam, Bernard, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (MGD) Service de chirurgie cardio-vasculaire et thoracique, Coussement, Julien, Lebeaux, David, van Delden, Christian, Guillot, Hélène, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Van Wijngaerden, Eric, Douvry, Benoit, Van Laecke, Steven, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean-Philippe, Rodriguez-Nava, Veronica, Lortholary, Olivier, Jacobs, Frédérique, European Study Group for Nocardia in Solid Organ Transplantation, Belhaj, Asmae, De Greef, Julien, Rodriguez-Villalobos, Hector, and Vandercam, Bernard

Abstract

Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplant (SOT). The aim of this study was to identify risk factors for Nocardia infection after SOT and to describe the presentation of nocardiosis in these patients. We performed a retrospective case-control study of adult patients diagnosed with nocardiosis after SOT between 2000 and 2014 in 36 European (France, Belgium, Switzerland, the Netherlands, Spain) centers. Two control subjects per case were matched by institution, transplant date, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors for nocardiosis. One hundred and seventeen cases of nocardiosis and 234 control patients were included. Nocardiosis occurred at a median of 17.5 (range, 2-244) months after transplant. In multivariable analysis, high calcineurin inhibitor trough levels in the month before diagnosis (odds ratio [OR], 6.11; 95% confidence interval [CI], 2.58-14.51), use of tacrolimus (OR, 2.65; 95% CI, 1.17-6.00) and corticosteroid dose (OR, 1.12; 95% CI, 1.03-1.22) at the time of diagnosis, patient age (OR, 1.04; 95% CI, 1.02-1.07), and length of stay in the intensive care unit after SOT (OR, 1.04; 95% CI, 1.00-1.09) were independently associated with development of nocardiosis; low-dose cotrimoxazole prophylaxis was not found to prevent nocardiosis. Nocardia farcinica was more frequently associated with brain, skin, and subcutaneous tissue infections than were other Nocardia species. Among the 30 cases with central nervous system nocardiosis, 13 (43.3%) had no neurological symptoms. We identified 5 risk factors for nocardiosis after SOT. Low-dose cotrimoxazole was not found to prevent Nocardia infection. These findings may help improve management of transplant recipients.

Published
2016

76. COL 8-02 - Facteurs de risque de nocardiose après transplantation d'organe :première étude rétrospective cas-témoin européenne

Author

Lebeaux, David, Lortholary, Olivier, Coussement, Julien, van Delden, Christian, Guillot, Hélène, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Rodriguez-Nava, Veronica, Jacobs, Frédérique, Lebeaux, David, Lortholary, Olivier, Coussement, Julien, van Delden, Christian, Guillot, Hélène, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Rodriguez-Nava, Veronica, and Jacobs, Frédérique

Abstract

SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

77. Nocardia Infection in Solid Organ Transplant Recipients: A Multicenter European Case-control Study.

Author

Coussement, Julien, Lebeaux, David, van Delden, Christian, Guillot, Hélène, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Van Wijngaerden, Eric, Douvry, Benoit, Van Laecke, Steven, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean Philippe, Rodriguez-Nava, Veronica, Lortholary, Olivier, Jacobs, Frédérique, European Study Group for Nocardia in Solid Organ Transplantation, Coussement, Julien, Lebeaux, David, van Delden, Christian, Guillot, Hélène, Freund, Romain, Marbus, Sierk, Melica, Giovanna, Van Wijngaerden, Eric, Douvry, Benoit, Van Laecke, Steven, Vuotto, Fanny, Tricot, Leïla, Fernández-Ruiz, Mario, Dantal, Jacques, Hirzel, Cédric, Jais, Jean Philippe, Rodriguez-Nava, Veronica, Lortholary, Olivier, Jacobs, Frédérique, and European Study Group for Nocardia in Solid Organ Transplantation

Abstract

Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplant (SOT). The aim of this study was to identify risk factors for Nocardia infection after SOT and to describe the presentation of nocardiosis in these patients., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

78. Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients

Author

Bartolucci, Pablo, primary, Habibi, Anoosha, additional, Khellaf, Mehdi, additional, Roudot-Thoraval, Françoise, additional, Melica, Giovanna, additional, Lascaux, Anne-Sophie, additional, Moutereau, Stéphane, additional, Loric, Sylvain, additional, Wagner-Ballon, Orianne, additional, Berkenou, Jugurtha, additional, Santin, Aline, additional, Michel, Marc, additional, Renaud, Bertrand, additional, Lévy, Yves, additional, Galactéros, Frédéric, additional, and Godeau, Bertrand, additional

Published
2016
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79. Delayed hemolytic transfusion reaction in adult sickle‐cell disease: presentations, outcomes, and treatments of 99 referral center episodes

Author

Habibi, Anoosha, primary, Mekontso‐Dessap, Armand, additional, Guillaud, Constance, additional, Michel, Marc, additional, Razazi, Keyvan, additional, Khellaf, Mehdi, additional, Chami, Btissam, additional, Bachir, Dora, additional, Rieux, Claire, additional, Melica, Giovanna, additional, Godeau, Bertrand, additional, Galacteros, Frédéric, additional, Bartolucci, Pablo, additional, and Pirenne, France, additional

Published
2016
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80. Dual Invasive Infection with Phaeoacremonium parasiticum and Paraconiothyrium cyclothyrioides in a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of Phaeoacremonium Phaeohyphomycosis

Author

Colombier, Marie-Alice, primary, Alanio, Alexandre, additional, Denis, Blandine, additional, Melica, Giovanna, additional, Garcia-Hermoso, Dea, additional, Levy, Bénédicte, additional, Peraldi, Marie-Noëlle, additional, Glotz, Denis, additional, Bretagne, Stéphane, additional, and Gallien, Sébastien, additional

Published
2015
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82. Gram-positive bacterial resistance: future treatment options

Author

Bassetti, Matteo, Melica, Giovanna, Di Biagio, Antonio, Rosso, Raffaella, Gatti, Giorgio, and Bassetti, Dante

Subjects
Cross Infection, Treatment Outcome, Anti-Infective Agents, Molecular Structure, Drug Resistance, Bacterial, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Humans, Microbial Sensitivity Tests, Randomized Controlled Trials as Topic, Drug Resistance, Bacterial
Abstract

Gram-positive infections are a major burden on patients and healthcare systems globally, and the need to treat these infections correctly in an empirical manner has become paramount. Further complicating this changing etiology is the emergence of resistant strains which are no longer predictably susceptible to standard first-line antimicrobials such as oxacillin or vancomycin. Thus, new agents such as linezolid have been developed to alleviate the 'guesswork' of initial empirical prescribing in infections where Gram-positive pathogens may be present. Future agents also being developed for multiresistant Gram-positive infections include evernimicin antibiotics, daptomycin, oritavancin, glycylcyclines and novel broad-spectrum cephalosporins; however, these are still in the development phase.

Published
2003

83. Initiation of c-ART in HIV-1 Infected Patients Is Associated With a Decrease of the Metabolic Activity of the Thymus Evaluated Using FDG-PET/Computed Tomography

Author

Lelièvre, Jean-Daniel, primary, Melica, Giovanna, additional, Itti, Emmanuel, additional, Lacabaratz, Christine, additional, Rozlan, Sandra, additional, Wiedemann, Aurélie, additional, Cheynier, Rémi, additional, Meignan, Michel, additional, Thiebaut, Rodolphe, additional, and Levy, Yves, additional

Published
2012
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86. Cutaneous Macroglobulinosis

Author

Gressier, Ludivine, primary, Hotz, Claire, additional, Lelièvre, Jean-Daniel, additional, Carlotti, Agnès, additional, Buffet, Marc, additional, Wolkenstein, Pierre, additional, Bagot, Martine, additional, Melica, Giovanna, additional, and Ortonne, Nicolas, additional

Published
2010
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87. Relevance of EORTC Criteria for the Diagnosis of Invasive Aspergillosis inHIV-InfectedPatients, and Survival Trends Over a 20-Year Period in France.

Author

Denis, Blandine, Guiguet, Marguerite, de Castro, Nathalie, Mechaï, Frédéric, Revest, Matthieu, Melica, Giovanna, Costagliola, Dominique, and Lortholary, Olivier

Subjects
ANTIRETROVIRAL agents, COMBINATION drug therapy, ASPERGILLOSIS diagnosis, ASPERGILLOSIS treatment, PUBLIC health
Abstract

Background: Before the advent of combination antiretroviral therapy (cART), roughly 50% of cases of invasive aspergillosis (IA) associated with human immunodeficiency virus (HIV) infection involved individuals without classical predisposing host factors, and the median survival time was <4 months after diagnosis. We examined if the situation evolved over time using the revised European Organisation for Research and Treatment of Cancer/National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC) definition and analyzed survival trends after diagnosis over 20 years. Methods: A data review committee evaluated 342 medical records that mentioned IA in the French Hospital Database on HIV. Validated cases were classified as fulfilling the EORTC criteria or otherwise as "HIV-related IA." Three periods were analyzed: pre-cART (before 1996), cART era prevoriconazole (1996-2001), and 2002-2011. Results: Among 242 validated cases of IA, 124 (51%) fulfilled the EORTC criteria (EORTC-IA) and 118 (49%) were classified as "HIV-related," with similarly low CD4 cell counts in both groups. The proportion of EORTC-IA cases remained stable across the 3 periods (50%, 48%, and 54%, respectively). The 3-month survival rate improved after the advent of cART (38% vs 69%), with no difference between EORTC-IA and HIV-related IA (hazard ratio [HR], 1.2 95% confidence interval [CI] {0.7-1.8}). Voriconazole exposure decreased mortality in 2002-2011 (HR, 0.1 95% CI [0.01-0.8]). Conclusions. In the cART era, EORTC criteria, developed for use in hematology/oncology, still applied to only half the cases diagnosed among HIV-infected patients. A rapid diagnosis of IA is paramount to improve survival. For patients who do not fulfill the EORTC definition, we suggest that the addition of "HIV infected with a CD4 count <100 cells/μL" to the EORTC host criteria be validated. [ABSTRACT FROM AUTHOR]

Published
2015
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90. Dual Invasive Infection with Phaeoacremonium parasiticumand Paraconiothyrium cyclothyrioidesin a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of PhaeoacremoniumPhaeohyphomycosis

Author

Colombier, Marie-Alice, Alanio, Alexandre, Denis, Blandine, Melica, Giovanna, Garcia-Hermoso, Dea, Levy, Bénédicte, Peraldi, Marie-Noëlle, Glotz, Denis, Bretagne, Stéphane, and Gallien, Sébastien

Abstract

ABSTRACTDespite increasing reports of human infection, data about the optimal care of Phaeoacremoniuminfections are missing. We report a case of an infection due to Phaeoacremonium parasiticumand Paraconiothyrium cyclothyrioides, initially localized to skin and soft tissue, in a kidney transplant patient. Despite surgical drainage and excision of the lesion and combination antifungal therapy with voriconazole and liposomal amphotericin B, a disseminated infection involving the lungs and brain developed and led to death. We performed a systematic literature review to assess the general features and outcome of human infections due to Phaeoacremoniumspecies. Thirty-six articles were selected, and 42 patients, including ours, were reviewed. Thirty-one patients (74%) were immunocompromised because of organ or bone marrow transplantation (n= 17), diabetes or glucose intolerance (n= 10), rheumatoid arthritis or Still's disease (n= 4), chronic hematological diseases (n= 3), or chronic granulomatous disease (n= 3). Ten patients (24%) reported initial cutaneous trauma. Skin and soft tissue infections represented 57% of infections (n= 24), and disseminated infections, all occurring in immunocompromised patients, represented 14% of infections (n= 6). The main antifungal drugs used were azoles (n= 41) and amphotericin B (n= 16). Surgical excision or drainage was performed in 64% of cases (n= 27). The cure rate was 67% (n= 28). There were 10% cases of treatment failure or partial response (n= 4), 19% relapses (n= 8), and 7% losses to follow-up (n= 3). The death rate was 19% (n= 8). Management of Phaeoacremoniuminfections is complex because of slow laboratory identification and limited clinical data, and treatment relies on a combination of surgery and systemic antifungal therapy.

Published
2015
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91. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

Author

Bureau, Serge, Dougados, Maxime, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Dalibey, Sarah, Raked, Nabil, Mameri, Lakhdar, Alary, Stéphanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Montlahuc, Claire, Biard, Lucie, Charreteur, Robin, Dupré, Celine, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Bulifon, Sophie, Jaïs, Xavier, Sitbon, Olivier, Pavy, Stéphan, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stéphane, Baudry, Elodie, Verny, Christiane, Noaillon, Mathilde, Lefèvre, Edouard, Zaidan, Mohamad, Le Tiec, Clotilde Le Tiec, Verstuyft, Céline Verstuyft, Roques, Anne-Marie, Grimaldi, Lamiae, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Solène, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Georgin-Lavialle, Sophie, Senet, Patricia, Soria, Angèle, Parrot, Antoine, François, Hélène, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadège, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefèvre, Guillaume, Fallet, Vincent, Gottenberg, Jacques-Eric, Hansmann, Yves, Andres, Emmanuel, Bayer, Sophie, Becker, Guillaume, Blanc, Frédéric, Brin, Stéphane, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Demonsant, Eric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurélien, Heger, Bob, Hutt, Anne, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Martin, Tristan, Mertes, Paul Michel, Metzger, Catherine, Meyer, Nicolas, Nisand, Gabriel, Noll, Eric, Oberlin, Mathieu, Ohlmann-Caillard, Sophie, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Sublon, Cédric, Tayebi, Hakim, Weill, François, Mekinian, Arsène, Chopin, Dorothée, Fain, Olivier, Garnier, Marc, Krause le Garrec, Jessica, Morgand, Marjolaine, Pacanowski, Jerome, Urbina, Tomas, McAvoy, Chloe, Pereira, Maria, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Daguenel-Nguyen, Anne, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Se'bastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Penet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Denis, Jesuthasan, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Vale'rie, Tre'han, Anne, Vigna, Ve'ronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charle'ne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, F-Xavier, Ghosn, Jade, BACHELARD, Antoine, BIRONNE, Timothee, BORIE, Raphael, BOUNHIOL, Agathe, BOUSSARD, Catherine, CHAUFFiER, Jeanne, CHALAL, Solaya, CHALAL, Lynda, CHANSOMBAT, Malikhone, CRESPIN, Paul, CRESTANI, Bruno, DACONCEICAO, Olivia, DECONINCK, Laurene, DIEUDE, Philippe, DOSSIER, Antoine, DUBERT, Marie, DUCROCQ, Greggory, FUENTES, Axelle, GERVAIS, Anne, GILBERT, Marie, ISERNIA, Valentina, ISMAEL, Sophie, JOLY, Veronique, JULIA, Zelie, LARIVEN, Sylvie, LE GAC, Sylvie, LE PLUART, Diane, LOUNI, Francoise, NDIAYE, Awa, PAPO, Thomas, PARISEY, Marion, PHUNG, Bao, POURBAIX, Annabelle, RACHLINE, Anne, RIOUX, Christophe, SAUTEREAU, Aurelie, STEG, Gabriel, TARHINI, Hassan, VALAYER, Simon, VALLOIS, Dorothee, VERMES, Paul, VOLPE, Thomas, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anaïs, Zarrouk, Virginie, De Lastours, Victoire, Uzzan, Matthieu, Olivier, Olivier, Rossi, Geoffrey, Gamany, Naura, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, De Castro, Nathalie, Clément, Melissa, Darmont, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lengliné, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asmaa, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Celli Lebras, Karine, Chabert, Julien, Djaghout, Lalia, Fauvaux, Catherine, Jegu, Anne Lise, Kozaliewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madeleine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, SENE, Damien, BURLACU, Ruxandra, CHOUSTERMAN, Benjamin, MEGARBANE, Bruno, RICHETTE, Pascal, RIVELINE, Jean-Pierre, FRAZIER, Aline, VICAUT, Eric, BERTON, Laure, HADJAM, Tassadit, VASQUEZ-IBARRA, Miguel Alejandro, JOURDAINE, Clément, JACOB, Aude, SMATI, Julie, RENAUD, Stéphane, MANIVET, Philippe, PERNIN, Claire, SUAREZ, Lydia, Semerano, Luca, ABAD, Sebastien, Benainous, Ruben, Bloch Queyrat, Coralie, Bonnet, Nicolas, Brahmi, Sabrina, Cailhol, johann, Cohen, Yves, Comparon, Celine, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Jacolot, Anne, Nunes, Hilario, Oziel, Johanna, Rathouin, Vanessa, Rigal, Marthe, Roulot, Dominique, Tantet, Claire, Uzunhan, Yurdagul, COSTEDOAT-CHALUMEAU, Nathalie, Ait Hamou, Zakaria, Benghanem, Sarah, BLANCHE, Philippe, CANOUI, Etienne, CARLIER, Nicolas, CHAIGNE, Benjamin, CONTEJEAN, Adrien, DUNOGUE, Bertrand, DUPLAND, Pierre, DUREL - MAURISSE, Aurélie, GAUZIT, Remy, JAUBERT, Paul, Joumaa, Hassan, Jozwiak, Mathieu, KERNEIS, Solen, LACHATRE, Marie, Lafoeste, Hélène, LEGENDRE, Paul, LUONG NGUYEN, Liem Binh, MAREY, Jonathan, MORBIEU, Caroline, MOUTHON, Luc, NGUYEN, Lee, Palmieri, Lola-Jade, REGENT, Alexis, SZWEBEL, Tali-Anne, TERRIER, Benjamin, GUERIN, Corinne, ZERBIT, Jérémie, CHEREF, Kahina, CHITOUR, Kamil, CISSE, Mamadou Salif, CLARKE, Ada, CLAVERE, Gaelle, DUSANTER, Isabelle, GAUDEFROY, Caroline, JALLOULI, Moez, KOLTA, Sami, LE BOURLOUT, Catherine, MARIN, Nathalie, MENAGE, Nathalie, MOORES, Alexandre, PEIGNEY, Isabelle, PIERRON, Cédric, SALEH-MGHIR, Samira, VALLET, Mathilde, MICHEL, Marc, MELICA, Giovanna, LELIEVRE, Jean-Daniel, FOIS, Elena, LIM, Pascal, MATIGNON, Marie, GUILLAUD, Constance, THIEMELE, Alaki, SCHMITZ, David, BOUHRIS, Marion, BELAZOUZ, Syllia, LANGUILLE, Laetitia, MEKONTSO-DESSAPS, Armand, SADAOUI, Thiziri, Mayaux, Julien, Cacoub, Patrice, Corvol, Jean-Christophe, Louapre, Céline, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aïcha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sébastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Lecronier, Marie, Beurton, Alexandra, Haudebourg, Luc, Deleris, Robin, Le Marec, Julien, Virolle, Sara, Nemlaghi, Safaa, Bureau, Côme, Mora, Pierre, De Sarcus, Martin, Clovet, Olivier, Duceau, Baptiste, Grisot, Paul Henri, Pari, Marie hélène, Arzoine, Jérémy, Clarac, Ulrich, Faure, Morgane, Delemazure, Julie, Decavele, Maxence, Morawiec, Elise, Demoule, Alexandre, Dres, Martin, Vautier, Mathieu, Allenbach, Yves, Benveniste, Olivier, Leroux, Gaelle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Cloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Gonçalo, Ferfar, Yasmina, Charbonnier, Fanny, AGUILAR, Claire, ALBY-LAURENT, Fanny, ALYANAKIAN, Marie-Alexandra, BAKOUBOULA, Prissile, BROISSAND, Christine, BURGER, Carole, CAMPOS-VEGA, Clara, CHAVAROT, Nathalie, CHOUPEAUX, Laure, FOURNIER, Benjamin, GRANVILLE, Sophie, ISSORAT, Elodie, ROUZAUD, Claire, VIMPERE, Damien, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Helene, Duclos-Vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Koumis, Ilias, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Chistophe, Sakkal, Madona, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El Amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Razurel, Anaïs, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Hélène, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Clan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Servettaz, Amélie, Deslée, Gaetan, Wynckel, Alain, Benoit, Philippe, Marquis, Eric, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Hélène, Mourad, Jean-Jacques, Sacco, Emmanuelle, and Renet, Sophie

Abstract

Patients with COVID-19 pneumonia have an excess of inflammation and increased concentrations of cytokines including interleukin-1 (IL-1). We aimed to determine whether anakinra, a recombinant human IL-1 receptor antagonist, could improve outcomes in patients in hospital with mild-to-moderate COVID-19 pneumonia.

Published
2021
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92. Nocardia infection in solid organ transplant recipients: a multicenter European case-control study

Author

Melica, Giovanna, Jacobs, Frédérique, Dantal, Jacques, Jais, Jean-Philippe, Marbus, Sierk, Lortholary, Olivier, Hirzel, Cédric, Tricot, Leïla, Douvry, Benoit, Vuotto, Fanny, Guillot, Hélène, Van Wijngaerden, Eric, Freund, Romain, Van Laecke, Steven, Fernández-Ruiz, Mario, Coussement, Julien, Van Delden, Christian, Lebeaux, David, and Rodriguez-Nava, Veronica

Subjects
610 Medicine & health, 3. Good health
Abstract

BACKGROUND Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplantation (SOT). The aim of this study was to identify risk factors for Nocardia infection after SOT and to describe the presentation of nocardiosis in these patients. METHODS We performed a retrospective case-control study of adult patients diagnosed with nocardiosis after SOT between 2000 and 2014 in 36 European (France, Belgium, Switzerland, Netherlands, Spain) centers. Two control subjects per case were matched by institution, transplant date and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors for nocardiosis. RESULTS One hundred and seventeen cases of nocardiosis and 234 control patients were included. Nocardiosis occurred at a median of 17.5 [range 2-244] months after transplantation. In multivariable analysis, high calcineurin inhibitor trough levels in the month before diagnosis (OR=6.11 [2.58-14.51]), use of tacrolimus (OR=2.65 [1.17-6.00]) and corticosteroid dose (OR=1.12 [1.03-1.22]) at the time of diagnosis, patient age (OR=1.04 [1.02-1.07]) and length of stay in intensive care unit after SOT (OR=1.04 [1.00-1.09]) were independently associated with development of nocardiosis; low-dose cotrimoxazole prophylaxis was not found to prevent nocardiosis. Nocardia farcinica was more frequently associated with brain, skin and subcutaneous tissue infections than were other Nocardia species. Among the 30 cases with central nervous system nocardiosis, 13 (43.3%) had no neurological symptoms. CONCLUSIONS We identified five risk factors for nocardiosis after SOT. Low-dose cotrimoxazole was not found to prevent Nocardia infection. These findings may help improve management of transplant recipients.

93. Nocardia Infection in Solid Organ Transplant Recipients: A Multicenter European Case-control Study.

Author

Coussement J, Lebeaux D, van Delden C, Guillot H, Freund R, Marbus S, Melica G, Van Wijngaerden E, Douvry B, Van Laecke S, Vuotto F, Tricot L, Fernández-Ruiz M, Dantal J, Hirzel C, Jais JP, Rodriguez-Nava V, Lortholary O, and Jacobs F

Subjects
Adult, Aged, Case-Control Studies, Europe epidemiology, Female, Humans, Logistic Models, Male, Middle Aged, Nocardia Infections microbiology, Nocardia Infections prevention & control, Opportunistic Infections microbiology, Opportunistic Infections prevention & control, Retrospective Studies, Risk Factors, Transplant Recipients, Calcineurin Inhibitors administration & dosage, Nocardia drug effects, Nocardia Infections epidemiology, Opportunistic Infections epidemiology, Transplants, Trimethoprim, Sulfamethoxazole Drug Combination administration & dosage
Abstract

Background: Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplant (SOT). The aim of this study was to identify risk factors for Nocardia infection after SOT and to describe the presentation of nocardiosis in these patients., Methods: We performed a retrospective case-control study of adult patients diagnosed with nocardiosis after SOT between 2000 and 2014 in 36 European (France, Belgium, Switzerland, the Netherlands, Spain) centers. Two control subjects per case were matched by institution, transplant date, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors for nocardiosis., Results: One hundred and seventeen cases of nocardiosis and 234 control patients were included. Nocardiosis occurred at a median of 17.5 (range, 2-244) months after transplant. In multivariable analysis, high calcineurin inhibitor trough levels in the month before diagnosis (odds ratio [OR], 6.11; 95% confidence interval [CI], 2.58-14.51), use of tacrolimus (OR, 2.65; 95% CI, 1.17-6.00) and corticosteroid dose (OR, 1.12; 95% CI, 1.03-1.22) at the time of diagnosis, patient age (OR, 1.04; 95% CI, 1.02-1.07), and length of stay in the intensive care unit after SOT (OR, 1.04; 95% CI, 1.00-1.09) were independently associated with development of nocardiosis; low-dose cotrimoxazole prophylaxis was not found to prevent nocardiosis. Nocardia farcinica was more frequently associated with brain, skin, and subcutaneous tissue infections than were other Nocardia species. Among the 30 cases with central nervous system nocardiosis, 13 (43.3%) had no neurological symptoms., Conclusions: We identified 5 risk factors for nocardiosis after SOT. Low-dose cotrimoxazole was not found to prevent Nocardia infection. These findings may help improve management of transplant recipients., (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)

Published
2016
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94. Initiation of c-ART in HIV-1 infected patients is associated with a decrease of the metabolic activity of the thymus evaluated using FDG-PET/computed tomography.

Author

Lelièvre JD, Melica G, Itti E, Lacabaratz C, Rozlan S, Wiedemann A, Cheynier R, Meignan M, Thiebaut R, and Levy Y

Subjects
HIV Infections virology, HIV-1 isolation & purification, Humans, Multimodal Imaging, Positron-Emission Tomography, Prospective Studies, T-Lymphocytes immunology, Thymus Gland diagnostic imaging, Tomography, X-Ray Computed, Anti-Retroviral Agents administration & dosage, Anti-Retroviral Agents adverse effects, Antiretroviral Therapy, Highly Active adverse effects, Antiretroviral Therapy, Highly Active methods, HIV Infections drug therapy, Thymus Gland drug effects, Thymus Gland metabolism
Abstract

Background: The role of the thymus in the depletion or restoration of T-cell pool in HIV infection is still debatable. Studies are hampered by the lack of valuable tools to investigate thymic activity., Methods: We have evaluated thymic activity using (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography and molecular and phenotypic analyses of thymic precursors. Longitudinal analyses were performed in HIV-infected patients either treatment naive with indication to initiate combination antiretroviral therapy (c-ART) (n = 11) or stable under c-ART (n = 9)., Results: Thymic standardized uptake value was significantly lower in c-ART-treated patients as compared with historical age-matched HIV-negative controls. In c-ART-naive patients, baseline thymic standardized uptake value correlated with T-cell repector excision circle levels and naive CD4+ T cells. These patients exhibited a high metabolic lymph node activity positively correlated to the percentage of activated HLA-DR+CD38+ T cells. Basal metabolic thymic activity predicts the gain in CD4+ T cells after c-ART initiation. A decrease of thymic activity, which paralleled circulating plasma IL-7 levels, was noted after c-ART initiation., Discussion: A metabolic thymic activity is detectable in c-ART naive and correlates with indirect phenotypic and molecular markers of thymic output. This activity may participate to the pool of peripheral naive CD4+ T cells and predicts the magnitude of T-cell reconstitution under treatment.

Published
2012
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95. Pulmonary artery thrombosis during acute chest syndrome in sickle cell disease.

Author

Mekontso Dessap A, Deux JF, Abidi N, Lavenu-Bombled C, Melica G, Renaud B, Godeau B, Adnot S, Brochard L, Brun-Buisson C, Galacteros F, Rahmouni A, Habibi A, and Maitre B

Subjects
Acute Chest Syndrome etiology, Acute Chest Syndrome physiopathology, Adult, Algorithms, Anticoagulants therapeutic use, Antifibrinolytic Agents blood, Biomarkers blood, Female, Fibrin Fibrinogen Degradation Products metabolism, Follow-Up Studies, Hospitals, University, Humans, Male, Pennsylvania epidemiology, Prevalence, Prospective Studies, Thrombosis complications, Thrombosis drug therapy, Thrombosis etiology, Acute Chest Syndrome complications, Anemia, Sickle Cell complications, Multidetector Computed Tomography, Pulmonary Artery, Thrombosis diagnostic imaging, Thrombosis epidemiology
Abstract

Rationale: The pathophysiology of acute chest syndrome (ACS) in patients with sickle cell disease is complex, and pulmonary artery thrombosis (PT) may contribute to this complication., Objectives: To evaluate the prevalence of PT during ACS using multidetector computed tomography (MDCT)., Methods: We screened 125 consecutive patients during 144 ACS episodes. One hundred twenty-one MDCTs (in 103 consecutive patients) were included in the study., Measurements and Main Results: Twenty MDCTs were positive for PT, determining a prevalence of 17% (95% confidence interval, 10-23%). Revised Geneva clinical probability score was similar between patients with PT and those without. D-dimer testing was very often positive (95%) during ACS. A precipitating factor for ACS was less frequently found in patients with PT as compared with those without. Patients with PT exhibited significantly higher platelet counts (517 [273-729] vs. 307 [228-412] 10(9)/L, P < 0.01) and lower bilirubin (28 [19-43] vs. 44 [31-71] μmol/L, P < 0.01) levels at the onset of ACS as compared with others. In addition, patients with PT had a higher platelet count peak (537 [345-785] vs. 417 [330-555] 10(9)/L, P = 0.048) and smaller bilirubin peak (36 [18-51] vs. 46 [32-83] μmol/L, P = 0.048)and lactate dehydrogenase peak (357 [320-704] vs. 604 [442-788] IU/L, P = 0.01) during hospital stay as compared with others., Conclusions: PT is not a rare event in the context of ACS and seems more likely in patients with higher platelet counts and lower hemolytic rate during ACS. Patients with sickle cell disease presenting with respiratory symptoms suggestive of ACS may benefit from evaluation for PT.

Published
2011
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