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To understand and improve age-friendly communication between religious congregations and local (state and international) agencies, an international, interdisciplinary team of gerontologists, practitioners, and college students initiated a six-part project consisting of two phases using a "town and gown" community engagement model. This initiative was aimed at 1) identifying current levels of service to older persons, the level of partnership between congregations and agencies, and plans for future senior program development; and 2) fostering greater access, communication, and collaboration between community agencies, congregations, and resources in aging using the internet. In Phase I, local leaders from senior service agencies (n=21) and local pastors (n=10) were interviewed by two groups of MSW students. Four other groups of MSW students developed and distributed directories containing local, state, and international resources on aging to participating congregations and agencies. In Phase II, BSW students completed a larger telephone survey of approximately 16% of available congregations in the city to assess services offered to older persons. That survey also helped to update a city-wide congregational directory, which was used to connect participating local congregations and agencies via the internet with the resources developed during Phase I. Practical problems involved in using the internet are discussed (e.g., limited internet access by underserved congregations), important service gaps are detailed (e.g., absence of disaster planning), and other outcomes related to future, age-friendly work in the community are described. [ABSTRACT FROM AUTHOR]

Global health practitioners and policymakers have become increasingly vocal about the complex challenges of identifying and quantifying the causes of death of the world's poorest people. To address this cause-of-death uncertainty and to minimise longstanding sensitivities about full autopsies, the Bill and Melinda Gates Foundation have been one of the foremost advocates of minimally invasive autopsy technology (MIA). MIA involves using biopsy needles to collect samples from key organs and body fluids; as such, it is touted as potentially more acceptable and less invasive than a complete autopsy, which requires opening the cadaver. In addition, MIA is considered a good means of collecting accurate bodily samples and can provide the crucial information needed to address cause-of-death uncertainty. In this paper, we employ qualitative data to demonstrate that while MIA technology has been introduced as a solution to the enduring cause-of-death uncertainty, the development and deployment of technologies such as these always constitute interventions in complex social and moral worlds; in this respect, they are both the solutions to and the causes of new kinds of uncertainties. We deconstruct the ways in which those new dimensions of uncertainty operate at different levels in the global health context. [ABSTRACT FROM AUTHOR]

Based on the unique features of morality, we suggest that group memberships rooted in moral convictions are a special classification of inherently threatening social groups in which outgroup 'hate' naturally occurs with ingroup 'love.' Three studies explored emotional reactions to ingroups and outgroups by individuals whose group memberships were either morality-based or non-morality-based. Results of each study indicated that individuals in morality-based groups reported less positive ingroup emotions and more negative outgroup emotions and threat than did those in non-morality-based groups. Additionally, strength of morality-based identification was predicted by attitudes about both the ingroup and the outgroup, but only attitudes about the ingroup predicted identification for non-morality-based groups. Together, these studies suggest a necessary interdependence of ingroup positivity and outgroup negativity for social groups based in morality. We conclude that negative outgroup-related emotions may be just as important as positive ingroup-related emotions for social identification based on moral convictions. [ABSTRACT FROM AUTHOR]

Abstract: A series of substituted pyridines, ether linked to a phenylpiperidine core were optimized for dual NK1/SERT affinity. Optimization based on NK1/SERT binding affinities, and minimization of off-target ion channel activity lead to the discovery of compound 44. In vivo evaluation of 44 in the gerbil forced swim test (a depression model), and ex-vivo NK1/SERT receptor occupancy data support the potential of a dual acting compound for the treatment of depression. [Copyright &y& Elsevier]

Based on ubiquitous presence of large ionic motifs and clusters in proteins involved in gene transcription and protein synthesis, we analyzed the distribution of ionizable sidechains in a broad selection of proteins with regulatory, metabolic, structural and adhesive functions, in agonist, antagonist, toxin and antimicrobial peptides, and in self-excising inteins and intron-derived proteins and sequence constructs. All tested groups, regardless of taxa or sequence size, show considerable segregation of ionizable sidechains into same type charge (homoionic) tracts. These segments in most cases exceed half of the sequence length and comprise more than two-thirds of all ionizable sidechains. This distribution of ionic residues apparently reflects a fundamental advantage of sorted electrostatic contacts in association of sequence elements within and between polypeptides, as well as in interaction with polynucleotides. While large ionic densities are encountered in highly interactive proteins, the average ionic density in most sets does not change appreciably with size of the homoionic segments, which supports the segregation as a modular feature favoring association. [ABSTRACT FROM AUTHOR]

Abstract: A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo γ-secretase activity were identified and described. [Copyright &y& Elsevier]

Background: Mesh use during hiatal hernia repair (HHR) has been suggested to be safe and effective. Concern has been raised about the risk of mesh-related complications, and the higher risk of complications if revisional hiatal surgery is undertaken after mesh has been used. Available data have not established a clear role for mesh in HHR. To assess surgeons' adoption of the use of mesh for HHR, SAGES members were surveyed regarding their practice related to mesh use for HHR. Methods: Between April and September 2010, an internet-based survey tool was used to survey SAGES members. Potential participants were contacted via e-mail and invited to complete the survey. Of the 5,323 attempted contacts, 5,024 reached active e-mail accounts. From these, 2,518 members responded (50% response rate). Results: The majority of respondents currently perform HHR (69%), but only 18% perform more than 20 per year. Of those who perform HHR, 94% use a laparoscopic approach for the majority of repairs. Whereas 25% of surgeons use mesh for the majority of repairs, 23% of surgeons never use mesh. When mesh is used, an absorbable mesh is most commonly used (67%). An onlay technique is used by 93% of respondents. Only 7% of surgeons who have been in practice more than 20 years use mesh compared with 59% of surgeons in practice less than 10 years. Fifty-seven percent of surgeons have never performed revisional foregut surgery on a patient with prior mesh. Conclusions: Although the majority of surgeons have used mesh for HHR, it is the minority who use it routinely, with younger surgeons more likely to use mesh than older surgeons. Absorbable mesh is most commonly used. When mesh is used, an onlay technique is most commonly used. There is no clear accepted use of mesh in hiatal hernia repair. [ABSTRACT FROM AUTHOR]

The objective of this study was to examine whether preoperative recommendation for specific reductions in body mass index (BMI) influenced weight loss in obese surgical patients. We retrospectively reviewed the electronic medical records of 48 patients who enrolled between January 2007 to June 2010 in an 800-calorie per day liquidmeal replacement (LMR)weight loss program. Of these, 9 patients (surgical group) enrolled as a result of general surgeon-directed weight loss to enable nonbariatric surgery and 39 enrolled seeking weight loss (medical group). Patients en- rolled in the LMR program before bariatric surgery were excluded from analysis. All patients were seen in the setting of a comprehensive weight loss program supervised by a medical bariatrician and followed for a period of 4 months. There were no significant differences in mean initial BMI between surgical and medical patients (41.7 ± 4.55 and 41.6 ± 8.54 kg/m² , respectively) or participation time in the weight loss program (120 days vs 133 days). Of the nine surgical patients, only five (56%) reached their weight goal and underwent the planned surgical procedure. Weight loss was significantly less in the surgical compared with medical patients (BMI reduction 4.03 ± 3.99 vs 7.75 ± 4.90 kg/m² , respectively; P < 0.05). Weight loss was significantly lower in patients directed to undergo BMI reduction to enable a general surgical procedure. Future studies are needed to assess factors influencing weight loss (metabolism, exercise capacity, motivation) in patients requiring weight loss to enable a surgical procedure. [ABSTRACT FROM AUTHOR]

Background: Increase in global health research undertaken in resource poor settings in the last decade though a positive development has raised ethical concerns relating to potential for exploitation. Some of the suggested strategies to address these concerns include calls for providing universal standards of care, reasonable availability of proven interventions and more recently, promoting the overall social value of research especially in clinical research. Promoting the social value of research has been closely associated with providing fair benefits to various stakeholders involved in research. The debate over what constitutes fair benefits; whether those that addresses micro level issues of justice or those focusing on the key determinants of health at the macro level has continued. This debate has however not benefited from empirical work on what stakeholders consider fair benefits. This study explores practical experiences of stakeholders involved in global health research in Kenya, over what benefits are fair within a developing world context. Methods and results: We conducted in-depth interviews with key informants drawn from within the broader health research system in Kenya including researchers from the mainstream health research institutions, networks and universities, teaching hospitals, policy makers, institutional review boards, civil society organisations and community representative groups. The range of benefits articulated by stakeholders addresses both micro and macro level concerns for justice by for instance, seeking to engage with interests of those facilitating research, and the broader systemic issues that make resource poor settings vulnerable to exploitation. We interpret these views to suggest a need for global health research to engage with current crises that face people in these settings as well as the broader systemic issues that produce them. Conclusion: Global health research should provide benefits that address both the micro and macro level issues of justice in order to forestall exploitation. Embracing the two is however challenging in terms of how the various competing interests/needs should be balanced ethically, especially in the absence of structures to guide the process. This challenge should point to the need for greater dialogue to facilitate value clarification among stakeholders. [ABSTRACT FROM AUTHOR]

Background: Transhiatal (two-field) esophagectomy reduces cardiopulmonary complications by avoiding thoracic access, but requires blind mediastinal dissection. The authors developed a minimally invasive esophagectomy (MIE) technique applying single-incision laparoscopy technology to better visualize the thoracic esophageal dissection. This is performed using laparoscopy and simultaneous transcervical videoscopic esophageal dissection (TVED). Our aim is to demonstrate feasibility of two-field MIE with TVED and improve recovery in high-risk patients. Methods: We performed a retrospective cohort study of eight patients who underwent two-field MIE with TVED over 10 months. The majority were male ( N = 6) with mean age of 63 ± 12 years. Mean body mass index (BMI) was 30.2 ± 5.1 kg/m. Indications for operation were: high-grade dysplasia ( N = 2), adenocarcinoma ( N = 6) with one receiving neoadjuvant chemoradiation. Using the Charlson comorbidity index, three patients were low risk and five were high risk. TVED was performed with a modified single-incision access device across the left neck. The mediastinal esophagus was dissected distally and circumferentially with simultaneous transabdominal laparoscopy for gastric conduit creation and distal esophageal dissection. Results: Mean operative time was 292 min (range 194-375 min). Three obese patients required temporary abdominal desufflation to avoid extrinsic mediastinal compression. Mean estimated blood loss was 119 mL (range 25-400 mL). A median of 23 lymph nodes (range 13-29) was harvested. Median intensive care unit (ICU) stay was 1 day (range 1-5 days), and median overall stay was 7 days (range 5-16 days). The three low-risk patients had no major complications. Three of five high-risk patients had major complications, including two cervical anastomotic leaks. Major complications were seen in three of four obese patients (BMI >30 kg/m). There were no mortalities. Conclusions: The TVED approach may avoid the morbidity of transthoracic esophageal dissection by improving esophageal visualization. Complications with TVED appear to correlate with obesity and comorbidities. Although TVED appears feasible, a larger experience is required. [ABSTRACT FROM AUTHOR]

The article offers information on a study conducted by the authors related to electrically induced contraction of the quadriceps femoris in men. It states that 18 healthy men with mean age of 24.9 years participated in the study in which they were exposed to fatiguing volitional quadriceps contraction and one of the three patterns of alternating current. It highlights that there was not significant difference in contraction durations or fatigue indexes of muscles before electrical stimulation.

The article explores the use of a physiologic approach in preventing cognitive biases with regards to intensive care unit (ICU). It discusses the condition of a patient who went surgery and had an increased risk for subsequent embolism and venous thrombosis. Also higlighted is the similarity of the carbon dioxide clearance from the body to the clearance of creatine from the kidney.

Background: Outcomes after ventral incisional hernia (VIH) repair are measured by recurrence rate and subjective measures. No objective metrics evaluate functional outcomes after abdominal wall reconstruction. This study aimed to develop testing of abdominal wall strength (AWS) that could be validated as a useful metric. Methods: Data were prospectively collected during 9 months from 35 patients. A total of 10 patients were evaluated before and after VIH repair, for a total of 45 encounters. The patients were tested simultaneously or in succession by two of three examiners. Data were collected for three tests: double leg lowering (DLL), trunk raising (TR), and supine reaching (SR). Raw data were compared and tested for validity, and continuous data were transformed to categorical data. Agreement was measured using the intraclass correlation coefficient (ICC) for DLL and using kappa for the ordinal measures. Results: Simultaneous testing yielded the following interobserver reliability: DLL (0.96 and 0.87), TR (1.00 and 0.95), and SR (0.76). Reproducibility was assessed by consecutive tests, with correlation as follows: DLL (0.81), TR (0.81), and RCH (0.21). Due to poor interobserver reliability for the SR test compared with the DLL and TR tests, the SR test was excluded from calculation of an overall score. Based on raw data distribution from the DLL and TR tests, the DLL data were categorized into 10º increments, allowing construction of a 10-point score. The median AWS score was 5 (interquartile range [IQR], 4-7), and there was agreement within 1 point for 42 of the 45 encounters (93%). Conclusions: The findings from this study demonstrate that the 10-point AWS score may measure AWS in an accurate and reproducible fashion, with potential for objective description of abdominal wall function of VIH patients. This score may help to identify patients suited for abdominal wall reconstruction while measuring progress after VIH repair. Further longitudinal outcomes studies are needed. [ABSTRACT FROM AUTHOR]

Background: Component separation technique (CST) enables rectus abdominus medialization, but may cause wound complications. Few published outcomes exist involving laparoscopic CST. Our aim was to examine feasibility and outcomes involving open and laparoscopic (lap) CST during ventral incisional hernia repair (VIHR) and present an algorithm for ventral herniorrhaphy. Study Design: Our design was a retrospective cohort study. Over 22 months, 28 patients underwent one of the following: (i) unilateral (U-) lap CST with open VIHR [ n=5], (ii) bilateral (B-) lap CST with open VIHR [ n=7], (iii) B-lap CST with lap VIHR [ n=8], or (iv) B-open CST with open VIHR [ n=8]. Indications for open VIHR included mesh removal, concomitant visceral procedure, wound revision, thin/ulcerated skin, abdominal wall tumor, frozen abdomen, and/or off-midline hernia. During open VIHR, CST was performed in the Ramirez fashion. Lap CST was performed before intraperitoneal access in lap VIHR and after retrorectus dissection in open VIHR. Patient surveillance consisted of clinical encounters and telephone interviews. Results: Groups were similar regarding age, body mass index, American Society of Anesthesiologists classification, hernia width, operative time, and hospital stay. Six of the 20 patients who underwent open VIHR developed wound complications, and two required early reoperation. Four of the six with concomitant visceral procedures had wound complications. No laparoscopic VIHR patients had a wound complication. Based on 11 months' follow-up, one open VIHR patient has concern for recurrence. Conclusions: Laparoscopic CST is feasible during open and laparoscopic VIHR, but it appears most beneficial for wound healing after laparoscopic VIHR. During open VIHR, laparoscopic CST may not substantially reduce wound complications. [ABSTRACT FROM AUTHOR]

Adrenal agenesis (AA) defined by the complete absence of development of adrenals is a rare anomaly, which is documented mainly in experimental animals and less frequently in human subjects in the literature. This study was aimed at describing the varied phenotype of this condition in two stillborn and one termination of pregnancy fetuses and two neonates, the associated abnormalities and the difficulties encountered to achieve the prenatal diagnosis. Five cases with AA diagnosed at post-mortem examination were selected and their characteristics were analyzed. The detection of this unusual condition has usually been made as an incidental discovery at post-mortem examination. None of the cases described in this series had been diagnosed at prenatal ultrasonography. Respiratory distress was the commonest clinical presentation in the liveborn. Maternal diabetes was associated with one case. Anomalies of kidneys, lungs, spleen, and blood vessels were associated with two of the cases. No gonadal abnormalities were detected in any of the cases. These cases illustrate the varied clinical presentation of this rare condition and confirm the difficulty in achieving a prenatal diagnosis. [ABSTRACT FROM AUTHOR]

Background There is an established link between depression and interest in hastened death in patients who are seriously ill. Concern exists over the extent of depression in patients who actively request euthanasia/physician-assisted suicide (PAS) and those who have their requests granted. Objectives To estimate the prevalence of depression in refused and granted requests for euthanasia/PAS and discuss these findings. Methods A systematic review was performed in MEDLINE and PsycINFO in July 2010, identifying studies reporting rates of depression in requests for and cases of euthanasia/PAS. One author critically appraised the strength of the data using published criteria. Results 21 studies were included covering four countries. There was considerable heterogeneity in methods of assessing depression and selecting patients. In the highest quality studies, in the Netherlands and Oregon, 8–47% of patients requesting euthanasia/PAS had depressive symptoms and 2–17% of completed euthanasia/PAS cases had depressive symptoms. In the Netherlands, depression was significantly higher in refused than granted requests, and there was no significant difference in the rate of depression between euthanasia cases and similar patients who had not made a request for euthanasia. Conclusion It is unclear whether depression increases the probability of making a request for euthanasia/PAS, but in the Netherlands most requests in depressed patients are rejected, leaving a depression rate in cases that is similar to the surrounding population. Less evidence is available elsewhere, but some level of depression has been identified in patients undergoing euthanasia/PAS in all the countries studied. Whether the presence of depression is ever compatible with an ethical decision on euthanasia/PAS is discussed. [ABSTRACT FROM PUBLISHER]

For many G-protein coupling receptors (GPCRs), the upkeep of receptor dimers could depend on association with functional Gi α subunits. This is known for Y1, Y2 and Y4 neuropeptide Y receptors [presented in the companion paper (Estes et al., Amino Acids, doi:, )]. Interactions with transducers use mainly intracellular domains of the receptors. Intracellular loops 1 and 2 in GPCRs are short and lack extensive helicity that could support transducer anchoring. Interaction with G-proteins is known to use the juxtamembrane Helix 8 in the fourth intracellular domain, for which we document a helix-stabilizing n/( n + 4) pattern of large hydrophobic sidechains. Another intracellular helix located in the C-terminal portion of the third intracellular loop does not display a strong stabilizing pattern, and is found in many studies to serve dynamically in association and activation of transducers and effectors. We show that these tracts share features across metazoan phyla not only in opsins and opsin-like receptors (including the Y receptors), but also in Taste-2 and Frizzled receptors. Similarities of these helices across GPCR groups could have both phylogenetic and functional roots. [ABSTRACT FROM AUTHOR]

Background: Mesh-assisted hiatal closure during foregut surgery is increasing. Our aim was to evaluate the complications that follow revisional foregut surgery. Specifically, we compared surgical indications and perioperative outcomes between patients with and without prior hiatal mesh (PHM). Methods: We conducted an institutional review board (IRB)-approved retrospective cohort study from a single tertiary-care referral center. Over 37 months, 91 patients underwent revisional foregut surgery. We excluded 13 cases including operations performed primarily for obesity or achalasia. Of the remaining 78 patients, 10 had PHM and 68 were nonmesh patients (NM). Results: The groups were similar in terms of age, body mass index (BMI), American Society of Anesthesiologists (ASA) classification, and rates and types of anatomic failure. Compared with NM patients, PHM patients had increased estimated blood loss (410 vs. 127 ml, p < 0.01) and operative time (4.07 vs. 2.89 h, p < 0.01). The groups had no difference in perioperative blood transfusion or length of stay. Complete fundoplication was more commonly created in NM patients (2/10 vs. 42/68, p = 0.03). Three of the 10 PHM patients and 3 of the 68 NM patients required major resection. Therefore, PHM patients had 6.8-fold increased risk of major resection compared with NM patients [95% confidence interval (CI) = 1.585, 29.17; p = 0.05]. The NM patients with multiple prior hiatal operations had 4.6-fold increased risk of major resection compared with those with one prior operation (95% CI = 2.919, 7.384; p = 0.03). In PHM patients, however, the number of prior hiatal operations was not associated with major resection. Conclusions: PHM is associated with increased risk of major resection at revision. The pattern of failure was not different in patients with hiatal mesh, suggesting that hiatal mesh does not eliminate the potential for revision. When performing hiatal herniorrhaphy, the increased risk of recurrence without mesh must be weighed against the potential risk for subsequent major resection when using mesh. [ABSTRACT FROM AUTHOR]

We discuss the possibility of a relativistic relationship between information and entropy, closely analogous to the classical Maxwell electro-magnetic wave equations. Inherent to the analysis is the description of information as residing in points of non-analyticity; yet ultimately also exhibiting a distributed characteristic: additionally analogous, therefore, to the wave-particle duality of light. At cosmological scales our vector differential equations predict conservation of information in black holes, whereas regular- and Z-DNA molecules correspond to helical solutions at microscopic levels. We further propose that regular- and Z-DNA are equivalent to the alternative words chosen from an alphabet to maintain the equilibrium of an information transmission system. [ABSTRACT FROM AUTHOR]

Few large studies have evaluated concordance based on a broad spectrum of human papillomavirus (HPV) types in oral and genital specimens of mothers and their recently born infants. This information is important in determining whether HPV vaccines administered prior to pregnancy may be useful for preventing vertical transmission. HPV DNA was positive in 30% of mothers and 1.5% of newborns. Maternal/newborn concordance (HPV+/+ or HPV-/-) was 71%. Among HPV DNA+ mothers, only 3% of their infants were DNA+ and only 1 pair had the same HPV type. Among HPV- women, 0.8% of infants were HPV+. HPV DNA detected in hospitalized newborns reflects current infection transmitted to infants during pregnancy or delivery. None of the mother/baby HPV DNA+ concordance pairs detected viral types found in HPV vaccines suggesting that vaccination prior to pregnancy is unlikely to be efficacious in preventing vertical transmission. [ABSTRACT FROM AUTHOR]

The minimal size of the fourth intracellular domain of heptahelical G-protein coupling receptors (GPCRs) is close to 15 residues, and a juxtamembrane 15-residue segment is predicted as helical (Helix-8) in most of the receptors. Sequences of opsins, non-visual opsin-like (family A) GPCRs and Taste-2 receptors correspond with bovine rhodopsin at four positions in this tract. This is especially evident in monoamine receptors. In most GPCRs, the conserved juxtamembrane segment also has a large fraction of basic sidechains, and a considerable excess of cationic over anionic residues. The conservation is not dependent on the preferred G-protein α subunit or the overall length of the domain, indicating an additive speciation. In rod opsins and some A-GPCRs this segment has been shown to associate with the bilayer and to interact with G-proteins. The segment could also be involved in precoupling of receptors and transducers. These interactions could be helped by both the structural propensities and the high content of cationic sidechains. [ABSTRACT FROM AUTHOR]

The authors reflect on the fair distribution of research resources. They note that there is only a small portion of medical research that addressed problems in the world's poorest people. They mention that the Ad Hoc Committee on Health Research and International Conference on Health Research for Development endorsed five core recommendations to address the need for a more equitable distribution of research resources. They explore the ethical issues in collaborative global health research.

The article focuses on the ethical data which was released by the Genome-wide association (GWA) in developing countries for a disease prevention tool. It mentions that the data that was released by GWA studies may not be fully understood unless it will be examined by several methods together with the combination of other datasets. It also adds that widespread consultation is the requirement for developing an appropriate and effective approach regarding the GWA released data.

Abstract: A full vehicle dynamics simulator was constructed in SimCreator® for the Cold Regions Research and Engineering Laboratory (CRREL) Instrumented Vehicle (CIV) and was used to investigate and validate the newly developed Vehicle Terrain Interaction (VTI) code. The VTI code replaces the tire component of the simulated vehicle, in the Driver and Motion Simulator (DMS), allowing it to report back realistic values while driving on various types of terrain surfaces such as mud, snow, ice, and pavement. The validation effort within this paper is focused on the winter (snow and ice) parts of the VTI code. The outputs from the Engineering Research and Development Center (ERDC) and the DMS VTI codes were validated through field experiments and against the North Atlantic Treaty Organization (NATO) Reference Mobility Model (NRMM). The DMS VTI code can be used with different vehicle models, providing the US. Army with a valuable asset that will allow simulation of existing or conceptual, manned or autonomous, ground vehicle performance for acquisition, planning, or training. This information, along with some basic terrain information, will allow troops to plan the fastest and most effective way of getting to a desired location, while minimizing the possibility of being delayed because of the terrain conditions. [Copyright &y& Elsevier]

The article presents an assessment of pleural pressure in the evaluation of pleural effusions. Pleural manometry provides data to enhance understanding of the underlying pleural pathophysiology when an effusion is present and aids the physician in both diagnostic and therapeutic decisions. The measurement of pleural pressure helps differentiate lung entrapment and trapped lung, allows for the safe removal of large effusions, and is a useful tool to select appropriate patients for pleurodesis.

This article examines Heaney's preoccupation in District and Circle (2006) with international political events during this 'new age of anxiety', and how he initially approaches these circuitously through a return to originary, boyhood experiences. Such momentous acts as the attacks of 9/ll, the 'War on Terror' and the London bombings are filtered through, juxtaposed with and illuminated by episodes both from the ancient past and Heaney's family history. In attendance, as always, throughout the latest volume is the poet's diverse literary ancestry, a reminder of how his work exemplifies core claims made in 'Tradition and the Individual Talent' (1919), where Eliot argues that 'what makes the writer most acutely conscious of his own place in time' is 'the historical sense', 'a feeling for the whole of literature' from Homer onwards. Thus, alongside its detailed address to politics and such crucial literary matters as structure, form and metaphor, the essay repeatedly returns to the intertextual 'presences' which haunt and animate Heaney's continuing creative project. [ABSTRACT FROM AUTHOR]

Abstract: With human neuropeptide Y Y2 receptor expressed in the Chinese hamster ovary (CHO) cells, the Asp35Ala mutation, and especially the change of Pro34Asp35 to Ala34Ala35, decrease the compartmentalization and strongly accelerate internalization of the receptor. These changes are not associated with alterations in agonist affinity, G-protein interaction, dimerization, or level of expression of the mutated receptors relative to the wildtype receptor. The proline-flanked aspartate in the N-terminal extracellular segment of the neuropeptide Y Y2 receptor thus apparently has a large role in anchoring and compartmentalization of the receptor. However, the Pro34Ala mutation does not significantly affect the embedding and cycling of the receptor. [Copyright &y& Elsevier]

The Human Fertilisation and Embryology Authority have recently granted a licence to perform preimplanation genetic diagnosis (PGD) for the homozygous form of familial hypercholesterolaemia (FH), explicitly excluding its use for the heterozygous form. The grounds for such decisions centre on how serious a condition is thought to be as well as on the availability of effective treatment, and decisions are made on a case-by-case basis. The case for licensing homozygous FH is discussed and compared with other cases, and the case for making a distinction between PGD for homozygous and heterozygous FH is also examined. Testing for homozygous FH raises difficult issues of non-disclosure of results for heterozygous FH. Fears that this decision may represent a 'slippery slope' to more widespread testing are argued to be overstated. [ABSTRACT FROM AUTHOR]

Objective: There is increasing debate about the ethics of using medical records for research. We aimed to characterize newspaper reporting in this area. Method: We searched Lexis-Nexis to find newspaper reports about the use of medical records for research from 1 June 2005 to 30 November 2006. Following screening for relevance, we generated a coding scheme and classified articles using this, assisted by QSR N6 software. Results: Our analysis shows that much newspaper coverage portrays the use of medical records as uncontentious, but also presents ethical arguments for and against such research. Arguments in favour of access to medical records emphasize the public interest and patients' legitimate expectations that research will be carried out. Arguments against such use emphasize the importance of confidentiality and the violation of rights of privacy. Our findings highlight that there is no single dominant position on the rights and wrongs of access to medical records by researchers. Within newspaper reporting in this area, patient voices are currently noticeable by their absence. Conclusions:Use of medical records for research raises important ethical questions, in particular regarding the balance between the rights and interests of the individual and the public interest benefits of the research. Understanding how these positions are represented within the mass media is important because the media can inform and influence the public's views and public policy. Empirical research into patient views is needed. [ABSTRACT FROM AUTHOR]

Abstract: We perform a differential temperature Carnot analysis of the changes in energy and entropy (degrees of freedom) associated with an ideal classical computing machine. Assuming that Carnot’s maximum efficiency law is as equally applicable to a computing machine as to a mechanical machine, we find that useful computation is necessarily dissipative and thermodynamically irreversible. In addition, we find that copying or cloning of information is as dissipative as the original process employed to create the information (through a computation) in the first place. We prove minimum heat dissipation kT ln2 per output calculation bit, where T is the thermodynamic temperature of unavoidable by-product bits (i.e. not the output calculation bits) rather than a generally assumed ‘surrounding environment’ temperature. Overall, this places computers into the same category as conventional machines, obeying the second law of thermodynamics and always operating below 100% efficiency, such that a perpetual calculating machine cannot exist. [Copyright &y& Elsevier]

Churches are often untapped resources to help the growing population of elders to age well. In this article, the author describes Alabama's "town and gown" model for organizing community-based, senior ministry associations; this model relies primarily on harnessing the collaborative synergy between academic institutions and congregations and by focusing on health and successful aging. [ABSTRACT FROM AUTHOR]

Eighteen years of field observations and five summer field experiments in a coastal California river suggest that hydrologic regimes influence algal blooms and the impacts of fish on algae, cyanobacteria, invertebrates, and small vertebrates. In this Mediterranean climate, rainy winters precede the biologically active summer low-flow season. Cladophora glomerata, the filamentous green alga that dominates primary producer biomass during summer, reaches peak biomass during late spring or early summer. Cladophora blooms are larger if floods during the preceding winter attained or exceeded "bankfull discharge" (sufficient to mobilize much of the river bed, estimated at 120 m3/s). In 9 out of 12 summers preceded by large bed-scouring floods, the average peak height of attached Cladophora turfs equaled or exceeded 50 cm. In five out of six years when flows remained below bankfull, Cladophora biomass peaked at lower levels. Flood effects on algae were partially mediated through impacts on consumers in food webs. In three experiments that followed scouring winter floods, juvenile steelhead (Oncorhynchus mykiss) and roach (Lavinia (Hesperoleucas) symmetricus) suppressed certain insects and young-of-the-year fish fry, affecting persistence or accrual of algae positively or negatively, depending on the predator-specific vulnerabilities of primary consumers capable of suppressing algae during a given year. During two post-flood years, these grazers were more vulnerable to small predators (odonates and fish fry, which stocked steelhead always suppressed) than to experimentally manipulated, larger fish, which had adverse effects on algae in those years. During one post-flood year, all enclosed grazers capable of suppressing algae were consumed by steelhead, which therefore had positive effects on algae. During drought years, when no bed-scouring winter flows occurred, large armored caddisflies (Dicosmoecus gilvipes) were more abundant during the subsequent summer. In drought-year experiments, stocked fish had little or no influence on algal standing crops, which increased only when Dicosmoecus were removed from enclosures. Flood scour, by suppressing invulnerable grazers, set the stage for fish mediated effects on algae in this river food web. Whether these effects were positive or negative depended on the predator-specific vulnerabilities of primary consumers that dominated during a given summer. [ABSTRACT FROM AUTHOR]

Abstract: Treatment with pertussis toxin in addition to a stable inhibition of Giα subunits of G-proteins also strongly reduced human neuropeptide Y Y1 receptors expressed in Chinese hamster ovary (CHO) cells. This was reflected in abolition of the inhibition by Y1 agonists of forskolin-stimulated adenylyl cyclase in intact cells, and of Y1 agonist stimulation of GTPγS binding to particulates from disrupted cells. The loss of both receptor and Giα subunit function was attenuated by ammonium chloride, an inhibitor of acid proteinases, pointing to a chaperoning co-protection of active pertussis toxin-sensitive Gα subunits and Y1 receptors. The surface complement of the Y1 receptor was changed a little in conditions of ∼85% decrease of the Y1 population, but the rate of the Y1 receptor-linked internalization of agonist peptides was reduced about 70%. The preserved receptor fraction consisted of monomers significantly coupled to Gqα subunits. The persistent pertussis toxin-insensitive internalization of agonists with the Y1 receptor may reflect a rescue or alternative switching that could be important for cell functioning in neuropeptide Y-rich environments. The results are compatible with a loss, due to Giα subunit inactivation by the toxin, of a large Y1 receptor reserve constituted of oligomers associating with heterotrimeric G-proteins. [Copyright &y& Elsevier]

Abstract: This paper situates discussion of the ethics of ethnographic research against the background of a theoretical and methodological debate about the relationship between ethics and method, and about the relationships between research methods and their objects. In particular, the paper investigates the implications of folding together the ethical and the empirical in research and argues that this requires the development of new ethico-ethnographic methods for the investigation of ethico-moral objects. The paper falls into three main parts. The first considers calls for what has come to be known as empirical ethics, that is, for a more empirically informed bioethics, by way of an exploration of the integration of ethnographic methods in bioethics, and concludes that approaches which see the ethical and the empirical as ‘complementary’ do not do justice to the methodological implications of enfolding the ethical and the ethnographic. The second part juxtaposes this with calls for the integration of ethics in ethnography and, similarly, argues that the enfolding of the ethical and the empirical in ethnography calls for the development of new methods. The paper goes on to problematise the ‘negotiational’ approaches to informed consent preferred by many ethnographers, arguing that the concept of negotiation, rather than offering a solution to the problem of consent, is itself ethically complex and in need of analysis. The paper argues that, in the context of ethnographic research, the possibility of negotiational forms of consent depends upon engagement between researchers and researched, with unavoidably ‘ethical’ concepts such as ‘respect’, ‘recognition’, ‘dignity’, ‘justice’ and so on, and that this poses methodological challenges to ethnography. The paper''s third section explores the implications of these arguments for research practice, using The Genethics Club as an example. [Copyright &y& Elsevier]

Skeletal muscle acidosis during exercise has long been thought to be a cause of fatigue, but recent studies have shown that acidosis maintains muscle excitability and opposes fatigue by decreasing the sarcolemmal chloride conductance. CIC-1 is the primary sarcolemmal chloride channel and has a clear role in controlling muscle excitability, but recombinant CIC-1 has been reported to be activated by acidosis. Following our recent finding that intracellular ATP inhibits CIC-1, we investigated here the interaction between pH and ATP regulation of CIC-1. We found that, in the absence of ATP, intracellular acidosis from pH 7.2 to 6.2 inhibited CIC-1 slightly by shifting the voltage dependence of common gating to more positive potentials, similar to the effect of ATP. Importantly, the effects of ATP and acidosis were cooperative, such that ATP greatly potentiated the effect of acidosis. Adenosine had a similar effect to ATP at pH 7.2, but acidosis did not potentiate this effect, indicating that the phosphates of ATP are important for this cooperativity, possibly due to electrostatic interactions with protonatable residues of CIC-1. A protonatable residue identified by molecular modeling, His-847, was found to be critical for both pH and ATP modulation and may be involved in such electrostatic interactions. These findings are now consistent with, and provide a molecular explanation for, acidosis opposing fatigue by decreasing the chloride conductance of skeletal muscle via inhibition of CIC-1. The modulation of CIC-1 by ATP is a key component of this molecular mechanism. [ABSTRACT FROM AUTHOR]

Abstract: A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo γ-secretase activity are reported. [Copyright &y& Elsevier]

Abstract: A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo γ-secretase activity. [Copyright &y& Elsevier]

Julian Savulescu argues for two principles of reproductive ethics: reproductive autonomy and procreative beneficence, where the principle of procreative beneficence is conceptualised in terms of a duty to have the child, of the possible children that could be had, who will have the best opportunity of the best life. Were it to be accepted, this principle would have significant implications for the ethics of reproductive choice and, in particular, for the use of prenatal testing and other reproductive technologies for the avoidance of disability, and for enhancement. In this paper, it is argued that this principle should be rejected, and it is concluded that while potential parents do have important obligations in relation to the foreseeable lives of their future children, these obligations are not best captured in terms of a duty to have the child with the best opportunity of the best life. [ABSTRACT FROM AUTHOR]

Abstract: Recent studies have suggested that computation is essentially reversible, provided no information is lost. This is a consequence of Landauer’s principle which only requires energy expenditure and entropy increase for information deletion. In this paper we propose to treat information as being intrinsic to points of non-analyticity, so that the movement of information is always associated with the dissipation of heat. This allows us to construct a theory consistent with causality, and the second law of thermodynamics. Since computation requires the movement of information bits through finite volume gates, energy is dissipated even when information is not destroyed, thus indicating that computation is fundamentally non-reversible. [Copyright &y& Elsevier]

The UK Genethics Club was established in November 2001 in order to provide a national forum of ethics support for the profession of clinical genetics in the UK. The forum brings together health professionals, medical ethicists and lawyers and support is provided through detailed discussion of cases and sharing of good practice. Clinical genetics professionals had previously voiced concerns about making extremely difficult ethical decisions, with profound implications, in something of a vacuum. Professionals saw a lack of guidance in the area and lack of time for discussion of difficult cases as reasons for this. This paper describes the origins of the group and gives (anonymized) examples of some of the types of issues discussed. [ABSTRACT FROM AUTHOR]

The theory, design, and tests are presented for a handheld unit that accurately monitors (and controls) the etch depth, rate, and surface roughness during wet etching. The unit features a noncontact optical probe using a low-power pulsed laser that circumvents light-induced etching. The etch monitor incorporates a 16-bit analog-to-digital converter with sample and hold, parallel ‘single chip’ processors, liquid crystal display and keypad, Personal Computer Memory Card International Association-based data storage, battery charger, an RS-232 COM port, and a parallel programming port. Tests performed on GaAs heterostructure etched in the phosphoric acid system indicate etch depth control better than 250 Å. The results include composition profiles and etch rates for reaction and diffusion rate limited etches. [ABSTRACT FROM AUTHOR]

The article focuses on the experiences of the lone white American member of a high school marching band in Clinton, North Carolina and how the squad once attempted to play the theme form the motion picture "Shaft." He described the rehearsals and execution of the performance at a football game. The author related how the squad, although the worst in the state, helped to immerse him in African-American culture and to understand the migration of rural southern African Americans to the urban north.

Genomic epidemiology is a field of research that seeks to improve the prevention and management of common diseases through an understanding of their molecular origins. It involves studying thousands of individuals, often from different populations, with exacting techniques. The scale and complexity of such research has required the formation of research consortia. Members of these consortia need to agree on policies for managing shared resources and handling genetic data. Here we consider data-sharing and intellectual property policies for an international research consortium working on the genomic epidemiology of malaria. We outline specific guidelines governing how samples and data are transferred among its members; how results are released into the public domain; when to seek protection for intellectual property; and how intellectual property should be managed. We outline some pragmatic solutions founded on the basic principles of promoting innovation and access. [ABSTRACT FROM AUTHOR]

A continuously variable true-time delay beamformer based on a multichannel chirped fiber grating (MCFG) is demonstrated. The beamformer is capable of wide-band squint-free operation and demonstrates beam steering of a four-element array over ±40°. The use of an MCFG provides a significant reduction in the length of the chirped grating required, eliminates spurious signal transmission, and utilizes narrow-band tunable laser sources. In addition, the effect of grating errors on the antenna pattern is examined and the tolerance on performance is presented. [ABSTRACT FROM AUTHOR]

Abstract: Numerous rhodopsin-like G-protein coupling receptors induce or inhibit angiogenesis. The active human receptors include several chemokine receptors, apelin APJ receptor, neuropeptide Y Y2 receptor, Duffy antigen, and herpes virus-8 receptor. A common and striking feature of these receptors is the large fraction (up to 42%) of residues with anionic sidechains (Asp, Glu, and benzene anions Tyr, Trp, and Phe) in the N-terminal extracellular domain. These residues (which are frequently clustered) can assist the binding of ligand peptides, but should also support interactions that help tubular arraying of cells, e.g., via cationic bridges and/or hydrogen bonding with cell-connecting receptors such as integrins, or with proteins of the extracellular matrix. [Copyright &y& Elsevier]

Current regulations do not allow most low-risk research using patient records without patient consent. One of the main reasons adduced for this is that such research constitutes an unacceptable breach of confidentiality. By contrast, it is argued in this paper that it may, on occasion, be acceptable for confidentiality to be breached according to all three of the major ethical justifications for respecting patient confidentiality. In practice, the arguments against allowing research using patient records are usually grounded in claims about the link between confidentiality and respect for patient autonomy rather than legitimate patient expectations. Patients may have good reason to expect, or come to expect, that their records will be used without their consent for low-risk research, under certain conditions. Where this is the case, such expectations provide reasonable grounds for considering such research to be ethical. [ABSTRACT FROM AUTHOR]