404 results on '"Zhang, Jian-fu"'
Search Results
152. The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells
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Li, Yu, primary, Zhang, Jian-fu, additional, Zhang, Yong-mei, additional, and Ma, Xiao-bo, additional
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- 2009
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153. JNK mediates the effects of oxytocin microinjected into the paraventricular nucleus on gastric ischemia-reperfusion in rats
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Zhang, Yong-Mei, primary, Zhang, Wen-Wen, additional, and Zhang, Jian-Fu, additional
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- 2009
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154. Administration of angiotensin II in the paraventricular nucleus protects gastric mucosa from ischemia-reperfusion injury
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Zhang, Yong-Mei, primary, Wei, Er-Qing, additional, Hu, Xia, additional, Xu, Ming, additional, Shi, Yue, additional, and Zhang, Jian-Fu, additional
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- 2008
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155. Capsaicin-sensitive afferent fibers mediate the protective effect of electrical stimulation of paraventricular nucleus against gastric ischemia-reperfusion injury in rats
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Zhang, Yong-Mei, primary, Zhang, Jian-Fu, additional, and Yan, Chang-Dong, additional
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- 2008
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156. EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAYS MAY MEDIATE THE PROTECTIVE EFFECT OF ELECTRICAL STIMULATION OF THE PARAVENTRICULAR NUCLEUS AGAINST ISCHAEMIA?REPERFUSION INJURY OF THE GASTRIC MUCOSA
- Author
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Zhang, Yong-Mei, primary, Wei, Er-Qing, additional, Li, Li, additional, Qiao, Wei-Li, additional, Wang, Lin, additional, and Zhang, Jian-Fu, additional
- Published
- 2007
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157. Extracellular signal-regulated kinase 1- and 2-mediated gastric mucosal injury and repair in gastric ischemia–reperfusion of rats
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Qiao, Wei-Li, primary, Wang, Lin, additional, Zhang, Yong-Mei, additional, Zhang, Jian-Fu, additional, and Wang, Guang-Ming, additional
- Published
- 2007
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158. Expression Characteristics of CD200 in Acute Myeloid Leukemia and Its Clinical Significance.
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ZHANG Xiao-Lu, SHEN An-Li, GUO Rui, WANG Yan, QIU Hai-Rong, QIAO Chun, YANG Hui, ZHANG Jian-Fu, LI Jian-Yong, and WU Yu-Jie
- Published
- 2014
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159. Mutation and Expression of LEF1 in Adult Acute Lymphocytic Leukemia and Their Clinical Significance.
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LIU Juan, GUO Xing, GE Zheng, ZHANG Run, XU Jing-Yan, LI Min, WU Yu-Jie, QIAO Chun, QIU Hai-Rong, ZHANG Jian-Fu, and LI Jian-Yong
- Published
- 2014
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160. Mutation and Expression of PAX5 Gene in Adult Acute Lymphoblastic Leukemia.
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LIN Zhong-Kun, ZHANG Run, GE Zheng, XU Jing-Yan, LIU Juan, GUO Xing, LI Min, WU Yu-Jie, QIAO Chun, QIU Hai-Rong, ZHANG Jian-Fu, and LI Jian-Yong
- Published
- 2014
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161. Characterization of Negative-Bias Temperature Instability of Ge MOSFETs With GeO2/Al2O3 Stack.
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Ma, Jigang, Zhang, Jian Fu, Ji, Zhigang, Benbakhti, Brahim, Zhang, Wei Dong, Zheng, Xue Feng, Mitard, Jerome, Kaczer, Ben, Groeseneken, Guido, Hall, Steve, Robertson, John, and Chalker, Paul R.
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METAL oxide semiconductor field-effect transistors , *TEMPERATURE effect , *GERMANIUM , *ALUMINUM oxide , *DIELECTRICS , *STRAINS & stresses (Mechanics) , *ENERGY levels (Quantum mechanics) , *ANNEALING of metals - Abstract
Ge is a candidate for replacing Si, especially for pMOSFETs, because of its high hole mobility. For Si-pMOSFETs, negative-bias temperature instabilities (NBTI) limit their lifetime. There is little information available for the NBTI of Ge-pMOSFETs with Ge/GeO2/Al2O3 stack. The objective of this paper is to provide this information and compare the NBTI of Ge- and Si-pMOSFETs. New findings include: 1) the time exponent varies with stress biases/field when measured by either the conventional slow dc or pulse I-V technique, making the conventional Vg -accelerated method for predicting the lifetime of Si-pMOSFETs inapplicable to Ge-pMOSFETs used in this paper; 2) the NBTI is dominated by positive charges (PCs) in dielectric, rather than generated interface states; 3) the PC in Ge/GeO2/Al2O3 can be fully annealed at 150 ^\circC ; and 4) the defect losses reported for Si sample were not observed. For the first time, we report that the PCs in oxides on Ge and Si behave differently, and to explain the difference, an energy-switching model is proposed for hole traps in Ge-MOSEFTs: their energy levels have a spread below the edge of valence band, i.e., Ev , when neutral, lift well above Ev after charging, and return below Ev following neutralization. [ABSTRACT FROM PUBLISHER]
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- 2014
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162. Evaluation and Solutions for P/E Window Instability Induced by Electron Trapping in High- $\kappa$ Intergate Dielectrics of Flash Memory Cells.
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Tang, Baojun, Zhang, Wei Dong, Degraeve, Robin, Breuil, Laurent, Blomme, Pieter, Zhang, Jian Fu, Ji, Zhigang, Zahid, Mohammed, Toledano-Luque, Maria, Van den Bosch, Geert, and Van Houdt, Jan
- Subjects
FLASH memory ,ELECTRON traps ,ELECTRON density ,DIELECTRICS ,ALUMINUM oxide ,POLYCRYSTALLINE silicon ,MULTILAYERS - Abstract
High density of electron trapping in high- \kappa intergate dielectric (IGD) materials remains a major concern for planar memory cells with either poly-Si or hybrid floating gates (FGs). In this paper, for the first time, using the ultrafast I{-}V measurements, it is demonstrated that a significant portion of the P/E windows are actually contributed by electrons trapped initially in the high- \kappa$ IGD stacks during program/erase, and then discharged to FG or control gate during verification. More importantly, it is demonstrated, for the first time, that this fast charge transition can be suppressed using novel multilayer high- $\kappa$ IGD structures, and the fast window instability can be eliminated. [ABSTRACT FROM PUBLISHER]
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- 2014
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163. Experimental Evidence Toward Understanding Charge Pumping Signals in 3-D Devices With Poly-Si Channel.
- Author
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Tang, Baojun, Zhang, Weidong, Toledano-Luque, Maria, Zhang, Jian Fu, Degraeve, Robin, Ji, Zhigang, Arreghini, Antonio, Van den Bosch, Geert, and Van Houdt, Jan
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ON-chip charge pumps ,POLYCRYSTALLINE silicon ,FLASH memory ,THRESHOLD voltage ,FIELD-effect transistors ,ELECTRON tunneling - Abstract
Poly-Si (p-Si) channel used in 3-D Flash memory devices is the main source of degraded performance, such as the high interface state density. Charge pumping (CP) signals in the 3-D nanoscale vertical device with p-Si channel are analyzed in this paper using the variable amplitude CP technique. For the first time, it has been demonstrated experimentally that the broad CP edge is due to the threshold voltage variation in the p-Si channel caused by both the trapping in interface states and the source/drain p-n junction diffusion, and their impacts can be separately evaluated. Hot carrier stress in the tunneling FET operation modes and statistical analysis are used to provide supporting evidence. [ABSTRACT FROM PUBLISHER]
- Published
- 2014
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164. Glutamate microinjection into the hypothalamic paraventricular nucleus attenuates ulcerative colitis in rats.
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Li, Ting-ting, Zhang, Jian-fu, Fei, Su-juan, Zhu, Sheng-ping, Zhu, Jin-zhou, Qiao, Xiao, and Liu, Zhang-bo
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PHYSIOLOGICAL effects of glutamic acid ,MICROINJECTIONS ,PARAVENTRICULAR nucleus ,COLITIS treatment ,ULCERATIVE colitis ,LABORATORY rats ,BENZENESULFONIC acid ,IMMUNOHISTOCHEMISTRY ,DRUG dosage - Abstract
Aim:To investigate the effects of glutamate microinjection into hypothalamic paraventricular nucleus (PVN) on ulcerative colitis (UC) in rats and to explore the relevant mechanisms.Methods:2,4,6-Trinitrobenzenesulfonic acid (100 mg/kg in 50% ethanol) was instilled into the colon of adult male SD rats to induce UC. A colonic damage score (CDS) was used to indicate the severity of the colonic mucosal damage. The pathological changes in the colonic mucosa were evaluated using immunohistochemistry, Western blotting, biochemical analyses or ELISA. Ten minutes before UC induction, drugs were microinjected into the relevant nuclei in rat brain to produce chemical stimulation or chemical lesion.Results:Microinjection of glutamate (3, 6 and 12 μg) into the PVN dose-dependently decreased the CDS in UC rats. This protective effect was eliminated after kainic acid (0.3 μg) was microinjected into PVN or into the nucleus tractus solitarius (NTS) that caused chemical lesion of these nuclei. This protective effect was also prevented when the AVP-V
1 receptor antagonist DPVDAV (200 ng) was microinjected into the NTS. The discharge frequency of the vagus was markedly decreased following microinjection of glutamate into the PVN. Microinjection of glutamate into the PVN in UC rats significantly increased the cell proliferation and anti-oxidant levels, and decreased the apoptosis and Bax and caspase 3 expression levels and reduced the pro-inflammatory factors in the colonic mucosa.Conclusion:The activation of hypothalamic PVN exerts protective effects against UC, which is mediated by the NTS and vagus. The effects may be achieved via anti-oxidative, anti-apoptotic, and anti-inflammatory factors. [ABSTRACT FROM AUTHOR]- Published
- 2014
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165. Characteristics of NOTCH1 Mutation in Adult T-cell Acute Lymphoblastic Leukemia.
- Author
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UN Zhong-Kun, ZHANG Run, GE Zheng, LIU Juan, GUO Xing, QIAO Chun, WU Yu-Jie, QIU Hai-Rong, ZHANG Jian-Fu, and LI Jian-Yong
- Published
- 2013
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166. Traps
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Zhang, Jian Fu, primary
- Published
- 1999
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167. The role of paraventricular nucleus of hypothalamus in stress-ulcer formation in rats
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Zhang, Jian-Fu, primary and Zheng, Fang, additional
- Published
- 1997
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168. Read and Pass Disturbance in the Programmed States of Floating Gate Flash Memory Cells With High-\kappa Interpoly Gate Dielectric Stacks.
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Tang, Baojun, Robinson, Colin, Zhang, Wei Dong, Zhang, Jian Fu, Degraeve, Robin, Blomme, Pieter, Toledano-Luque, Maria, Van den bosch, Geert, Govoreanu, Bogdan, and Van Houdt, Jan
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FLASH memory ,DIELECTRIC materials ,LOGIC circuits ,ELECTRON traps ,MECHANICAL models ,FIELD programmable gate arrays - Abstract
High-\kappa stacks have been used in the 20-nm generation of floating gate (FG) flash memory cells as the interpoly dielectric (IPD). However, electron trapping in high-\kappa materials remains a major concern for the further development of FG technology. For conventional FG cells, read/pass disturbance in the erased states is a major issue. In this paper, for the first time, it is observed that electron trapping/detrapping in the high-\kappa IPD layers can cause severe abnormal read/pass disturbances in the programmed states. Extensive evidence shows that this instability in programmed states originates from several competing mechanisms, including the redistribution of electron trapping between the IPD and FG and the electron discharging from FG/IPD into the control gate. This issue should be addressed in the development of future generations of FG Flash technology with higher-\kappa IPD materials. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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169. Muscimol microinjection into cerebellar fastigial nucleus exacerbates stress-induced gastric mucosal damage in rats.
- Author
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Zhu, Jin-zhou, Fei, Su-juan, Zhang, Jian-fu, Zhu, Sheng-ping, Liu, Zhang-bo, Li, Ting-ting, and Qiao, Xiao
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ORNITHINE ,MICROINJECTIONS ,GABA receptors ,GASTRIC mucosa ,LABORATORY rats ,CEREBELLAR peduncles ,WOUNDS & injuries - Abstract
Aim:To investigate the effects of microinjection of the GABA
A receptor agonist muscimol into cerebellar fastigial nucleus (FN) on stress-induced gastric mucosal damage and the underlying mechanism in rats.Methods:Stress-induced gastric mucosal damage was induced in adult male SD rats by restraining and immersing them in cold water for 3 h. GABAA receptor agonist or antagonist was microinjected into the lateral FN. The decussation of superior cerebellar peduncle (DSCP) was electrically destroyed and the lateral hypothalamic area (LHA) was chemically ablated by microinjection of kainic acid. The pathological changes in the gastric mucosa were evaluated using TUNEL staining, immunohistochemistry staining and Western blotting.Results:Microinjection of muscimol (1.25, 2.5, and 5.0 μg) into FN significantly exacerbated the stress-induced gastric mucosal damage in a dose-dependent manner, whereas microinjection of GABAA receptor antagonist bicuculline attenuated the damage. The intensifying effect of muscimol on gastric mucosal damage was abolished by electrical lesion of DSCP or chemical ablation of LHA performed 3 d before microinjection of muscimol. Microinjection of muscimol markedly increased the discharge frequency of the greater splanchnic nerve, significantly increased the gastric acid volume and acidity, and further reduced the gastric mucosal blood flow. In the gastric mucosa, further reduced proliferation cells, enhanced apoptosis, and decreased anti-oxidant levels were observed following microinjection of muscimol.Conclusion:Cerebellar FN participates in the regulation of stress-induced gastric mucosal damage, and cerebello-hypothalamic circuits contribute to the process. [ABSTRACT FROM AUTHOR]- Published
- 2013
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170. New Insights Into Defect Loss, Slowdown, and Device Lifetime Enhancement.
- Author
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Duan, Meng, Zhang, Jian Fu, Ji, Zhigang, Zhang, Wei Dong, Kaczer, Ben, De Gendt, Stefan, and Groeseneken, Guido
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ELECTRIC potential , *HIGH voltages , *METAL oxide semiconductor field-effect transistors , *CHARGE coupled devices , *MANUFACTURING defects , *PRODUCT liability - Abstract
Defects in gate oxide cause breakdown and shorten device lifetime. Early works mainly focused on generation process that converts a precursor into a charged defect. Although it can be neutralized through “recovery,” the defect is still there and will recharge when resuming stress. Recently, we have shown that this is not always the case and some defects can be lost, but a detailed investigation is missing. The central objective of this work is to accurately define and extract the loss, separate it from slowdown, and evaluate their enhancement of device lifetime. Loss is defined as elimination of defects, while slowdown means that recharging a “hardened” precursor takes longer than charging a fresh one. Clear evidences show that losses originate from permanent components, i.e., generated interface states and antineutralization positive charges, while slowdown occurs to both permanent and recoverable components. Loss is thermally accelerated, but slowdown of recoverable component is not. This improved understanding adds slowdown and losses to the existing framework for defects. For the first time, we report that the losses and slowdown enhance device lifetime by a factor of 2.6–4.3, for an allowed threshold voltage shift of 20–45 mV. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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171. Detection and Clinical Features of MLL Gene Rearrangement in Adult Patients with Acute Leukemia.
- Author
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LIU Ping, ZHANG Run, GE Zheng, LIN Zhong-Kun, LIU Juan, QIAN Si-Xuan, ZHANG Su-Jiang, LU Hua, WU Han-Xin, QIU Hong-Xia, LIU Peng, XU Wei, CHEN Li-Juan, LU Chao, LU Bin-Bin, QIAO Chun, QIU Hai-Rong, ZHU Guang-Rong, ZHANG Jian-Fu, and WU Yu-Jie
- Published
- 2012
172. TRAPS.
- Author
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Zhang, Jian Fu
- Subjects
DIELECTRICS ,MICROELECTRONICS ,SEMICONDUCTORS ,SILICON ,MICROTECHNOLOGY ,ELECTRICAL engineering materials - Abstract
This article will focus on traps in the dielectric. Traps are the defects, which can capture mobile charge carriers, in the dielectric. In microelectronic devices, traps appear in the bulk of dielectric, at the dielectric/semiconductor interface and within semiconductors. For the modem semiconductor industry, silicon dioxide and silicon are the most widely used dielectric and semiconductor, respectively. This article concentrates on the trap in the silicon dioxide prepared on silicon. There are two types of traps, acceptor-like and donor-like. The acceptor-like trap can capture electrons and form negative space charges.
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- 1999
173. Expression Characteristics of Isoforms of Ikaros and Helios in Patients with Leukemia and their Mechanism.
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Liu Ping, Ge Zheng, Un Zhong-Kun, Qian Si-Xuan, Qiao Chun, Zhang Jian-Fu, Wu Yu-Jie, Qiu Hai-Rong, Zhu Guang-Rong, and Li Jian-Yong
- Published
- 2012
174. Investigation of Abnormal VTH/VFB Shifts Under Operating Conditions in Flash Memory Cells With \Al2\O3 High-\kappa Gate Stacks.
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Tang, Baojun, Zhang, Wei Dong, Zhang, Jian Fu, Van den Bosch, Geert, Toledano-Luque, María, Govoreanu, Bogdan, and Van Houdt, Jan
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FLASH memory ,GATE array circuits ,DIELECTRICS ,ALUMINUM oxide ,ELECTRIC fields ,ANNEALING of metals - Abstract
\Al2\O3 high- \kappa stack is a strong candidate as the dielectric layer in Flash memory cells for technology generations beyond sub-20 nm. In this paper, the cause of abnormal VTH/VFB shift at low operating electric fields is investigated, i.e., VTH/VFB reduces at low positive gate biases and increases at low negative gate biases. It is found that this instability does not originate from the electrons trapping/detrapping from the gate nor from the dielectric relaxation. For the first time, extensive experimental evidences show that this shift is caused by as-grown mobile charges in \Al2\O3 layers generated by postdeposition annealing at 1000 ^\circ\C or above. Its impacts on program/erase windows and read/pass disturbance in Flash memory cells are also evaluated. [ABSTRACT FROM PUBLISHER]
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- 2012
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175. Heterogeneous leukemic clones identified by NPM1 mutation analysis in patient with acute monocytic leukemia.
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Qiao, Chun, Zhang, Run, Hong, Ming, Wang, Li, Zhang, Jian-Fu, Wu, Yu-Jie, Qiu, Hai-Rong, Qiu, Hong-Xia, Qian, Si-Xuan, Lu, Hua, Zhang, Su-Jiang, and Li, Jian-Yong
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LEUKEMIA ,THERAPEUTICS ,PHARMACOLOGY ,DRUG therapy ,CANCER - Abstract
NPM1 mutation is the most common molecular abnormality in patients with acute myeloid leukemia (AML), especially normal karyotype AML (NK-AML), and is associated with a favorable prognosis in the absence of concomitant FLT3-ITD. Like other molecular abnormalities such as FLT3-ITD, C/EBPα and c-Kit mutation, NPM1 mutation normally presents as a recurrent molecular abnormality. The NPM1 mutation is generally used as a molecular marker in the prognosis evaluation of a patient with AML. Here, we report a different case. He was first diagnosed with NPM1 mutation-positive acute monocytic leukemia. However, he achieved no remission, but the NPM1 mutation dramatically became negative after induction chemotherapy. Finally, he achieved complete remission after salvage chemotherapy and the NPM1 mutation was still negative. To our knowledge, this is a rare case according to the worldwide published literature. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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176. Clinical Value of Interphase Fluorescent In Situ Hybridization in Diagnosis of Core-binding Factor Acute Myelocytic Leukemia.
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Yang Hui, Fan Lei, Qiu Hai-Rong, Wang Rong, Zhang Jian-Fu, Wu Yu-Jie, Li Jian-Yong, and Liu Peng
- Published
- 2011
177. Sensitive voltammetric determination of paracetamol based on ionic liquid n-butyl pyridinium hexafluo-phosphate modified carbon paste electrode.
- Author
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Lou Guang-xin, Zhang Jian-fu, Shangguan Xiao-dong, Xaio Xue-hong, and Dang Shao-li
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IONIC liquids ,HYDROPHOBIC compounds ,VOLTAMMETRY ,CARBON electrodes ,ACETAMINOPHEN oxidation ,PYRIDINIUM compounds ,ELECTROCATALYSIS - Abstract
A carbon ionic liquid electrode (CILE), which was fabricated by mixing hydrophobic room temperature ionic liquid, n-butyl pyridinium hexailuophosphate ([BuPy] [PF
6 ]) ,with graphite powder, was used to investigate the electrochemical behaviors of paracetamol in 0. 1 moL/L acetate buffer solution (pH 4. 7) by cyclic voltamrnetry (CV), square wave voltammetry (SWV) and chronocoulometly. The peak-to-peak potential separation (▵Ep ) of paracetamol was 0. 088 V with scan rate of 0.1 V/s. The results showed that CILE exhibited better electrocatalysis for redox of paracetamol. Diffusion coefficient (D) was calculated as 1. 214 x 10-7 cm2 /s. The oxidation peak current versus concentration of paracetamol at CILE showed linearity in the range of 0. 5-10. 0 μmol/L (r = 0. 998 8) with a detection limit of 0. 01 μmol/L (S/N = 3). The proposed method was applied to determination of paracetamol in tablets and urine samples successfully. In addition, CILE was inexpensive, stable, repeatable and easy to be fabricated. [ABSTRACT FROM AUTHOR]- Published
- 2011
178. A Single Pulse Charge Pumping Technique for Fast Measurements of Interface States.
- Author
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Lin, L., Ji, Zhigang, Zhang, Jian Fu, Zhang, Wei Dong, Kaczer, Ben, De Gendt, Stefan, and Groeseneken, Guido
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INTERFACES (Physical sciences) ,TIME measurements ,STRAINS & stresses (Mechanics) ,PULSE measurement ,DIELECTRICS ,ELECTRIC transients - Abstract
Characterizing interface states is a key task, and it typically takes seconds when conventional techniques, such as charge pumping (CP), are used. The stress-induced degradation can recover substantially during this time, and there is a need to improve the measurement speed. The central task of this work is to reduce the measurement time for interface states from seconds to microseconds to minimize the recovery. A fast single pulse CP (SPCP) technique is developed. By exploring the differences in the transient currents corresponding to the two edges of the gate pulse, the net charges pumped into devices can be obtained, and their saturation level is used to evaluate interface states. Unlike the conventional CP (CCP) method, the contribution of currents during the plateaus of gate pulse is excluded for SPCP, making it less vulnerable to the interferences of gate leakage and defects within dielectrics. For the first time, the SPCP allows the recovery of interface states being monitored with a time resolution in microseconds. The results show that the recovery of stress-induced interface states is substantial within 100 \mu\s, which would be missed if the CCP were used. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
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179. Electron Trapping in HfAlO High-\kappa Stack for Flash Memory Applications: An Origin of Vth Window Closure During Cycling Operations.
- Author
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Zheng, Xue Feng, Robinson, Colin, Zhang, Wei Dong, Zhang, Jian Fu, Govoreanu, Bogdan, and Van Houdt, Jan
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ELECTRONS ,ENERGY policy ,FLASH memory ,DYNAMIC programming ,DIELECTRICS ,ENERGY levels (Quantum mechanics) - Abstract
Endurance is one of the key criteria for Flash memory technologies, particularly for the generations beyond 30 nm with high-\kappa materials. It is observed in this paper that the electron trapping in high-\kappa layers causes threshold-voltage window closure under dynamic program/erase cycling operations. This closure does not originate from the generation of new traps or from further trapping of electrons injected from the gate during erasing. By utilizing a recently developed multipulse technique, it is found that the energy distribution of the electron trapping in the high-\kappa layer significantly changes after cycling. Electron trapping at the deeper energy levels continuously increases as cycling proceeds, because it does not reach saturation within one programming pulse. The trapping in deep levels cannot be discharged under typical erase conditions, and an increase in deep-level trapping also causes a reduction of trapping at shallow levels. It is concluded that the window closure observed in this paper is caused by a combination of increased deep trapping after erasing and a reduction of shallow trapping after programming. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
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180. A New Multipulse Technique for Probing Electron Trap Energy Distribution in High- \kappa Materials for Flash Memory Application.
- Author
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Zheng, Xue Feng, Zhang, Wei Dong, Govoreanu, Bogdan, Zhang, Jian Fu, and van Houdt, Jan
- Abstract
A new discharge-based multipulse technique has been developed in this paper, which overcomes the shortcomings of the existing techniques, such as the charge pumping, charge injection and sensing, and two-pulse C–V techniques. It captures the energy signature for electron traps across high- \kappa materials and can be a useful tool for material selection during technology development. Trap distributions in \HfO2, \Al2\O3, and HfAlO have been compared to identify the effects of material variation. It is observed that hafnium gives the shallow traps at about 0.45 eV above the silicon conduction band bottom (Si ECB), and the deep traps at 0.8 eV below the Si ECB are caused by aluminum. HfAlO combines the features in \HfO2 and \Al2\O3. A peak near the Si ECB has been observed in all the three materials. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
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181. The role of nuclear factor-kappaB in the effect of angiotensin II in the paraventricular nucleus in protecting the gastric mucosa from ischemia-reperfusion injury in rats.
- Author
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Zhang Y, Wei E, Hu X, Qiao W, Shi Y, Xu M, Zhang J, Zhang, Yong-Mei, Wei, Er-Qing, Hu, Xia, Qiao, Wei-Li, Shi, Yue, Xu, Ming, and Zhang, Jian-Fu
- Abstract
Background: The purpose of this study was to elucidate the role of nuclear factor kappaB (NF-kappaB) in the development of gastric ischemia-reperfusion (GI-R) injury and in mediating the effects of angiotensin II (Ang II) in the paraventricular nucleus (PVN) on GI-R injury.Methods: GI-R injury was induced in rats by clamping the celiac artery for 30 min and then reperfusing for 1 h. A cannula was inserted into the unilateral PVN for microinjection of Ang II. The expressions and levels of NF-kappaB (p65), IkappaB-alpha, and phosphorylated IkappaB-alpha in rat gastric mucosa were examined by Western blotting and immunohistochemistry. A laser Doppler flowmeter was used to assess gastric blood flow (GBF). Malondialdehyde (MDA) was determined using the thiobarbituric acid (TBA) method, and superoxide dismutase (SOD) activity was determined by the xanthine/xanthine oxidase method.Results: Microinjection of Ang II (3, 30, and 300 ng) into the PVN dose-dependently inhibited GI-R injury. The levels and expressions of NF-kappaB (p65) and phosphospecific IkappaB-alpha protein increased 1 h after GI-R and were markedly reduced by microinjection of Ang II into the PVN. In contrast, the level and expression of IkappaB-alpha protein decreased 1 h after ischemia-reperfusion and recovered to the normal level by microinjection of Ang II into the PVN. The effects of Ang II were prevented by pretreatment with the Ang II AT1 receptor antagonist losartan (5 microg) microinjected into the lateral cerebral ventricle. Inhibition of NF-kappaB activity by pyrrolidine dithiocarbamate (PDTC, 200 mg/kg) produced similar effects in rats subjected to ischemia-reperfusion with or without microinjection of Ang II into the PVN. Administration of PDTC attenuated gastric mucosal injury and suppressed the activation of NF-kappaB (p65). Ang II microinjection into the PVN increased GBF and decreased the MDA content but did not alter SOD activity in the gastric mucosa following ischemia-reperfusion.Conclusions: NF-kappaB plays a role in PVN Ang II-mediated protection against GI-R injury. These central effects of Ang II are mediated by AT1 receptors. [ABSTRACT FROM AUTHOR]- Published
- 2008
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182. Experiment Research on Cutting Performance of High Volume Fraction SiCp/Al Composites in Rotary Ultrasonic Machining
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Liang, Gui Qiang, Zhang, Jian Fu, Feng, Ping Fa, Yu, Ding Wen, and Wu, Zhi Jun
- Abstract
High volume fraction silicon carbide particulate reinforced aluminum matrix (SiCp/Al) composite are new class of difficult-to-machine materials due to their high strength. This paper presents an experimental investigation on the machinability of 60 vol% SiCp/Al composites by comparing the rotary ultrasonic milling method with the conventional machining method. The test scheme is designed, and the measurement method of the cutting force, surface roughness and morphology are illustrated. Based on the constructed experimental platform, the influences of machining parameters, such as cutting speed, feed rate and cut depth, on the cutting force and surface roughness are discussed. The experimental results show that ultrasonic machining is an effective method for machining high volume fraction SiCp/Al.
- Published
- 2012
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183. Effect of Solid Solution Treatment on Microstructure of Fe-Ni Based High Strength Low Thermal Expansion Alloy
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ZHANG, Jian-fu, TU, Yi-fan, XU, Jin, ZHANG, Jian-sheng, and ZHANG, Jing-lin
- Abstract
The influence of solid solution treatments on the dissolution of carbides precipitates, the grain size, and the hardness of high strength low expansion alloy were investigated through XRD analysis, microstructure observations, and theoretical computation. It was seen that most primary Mo 2C type carbide band dissolved in a temperature range of 1 100–1 150 °C. When the temperature was over 1 200 °C, the grain size increased remarkably, which led to the reduction of hardness.
- Published
- 2008
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184. Development of Hybrid Rice Variety FY7206 with Blast Resistance Gene Pid3 and Cold Tolerance Gene Ctb1
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Xie HongGuang, Zhang Jian-fu, Zheng Yanmei, Cai Qiuhua, Zhu YongSheng, Xie Hua-an, Jiang Jia-huang, Wu FangXi, and Luo Xi
- Subjects
0301 basic medicine ,Total resistance ,blast resistance gene Pid3 ,Cold tolerance ,Plant Science ,Plant disease resistance ,lcsh:Plant culture ,hybrid rice ,03 medical and health sciences ,lcsh:SB1-1110 ,Gene ,Panicle ,biology ,Resistance (ecology) ,cold tolerance gene Ctb1 ,Cold resistance ,food and beverages ,biology.organism_classification ,yield ,Horticulture ,030104 developmental biology ,Agronomy ,Seedling ,breeding ,Agronomy and Crop Science ,Biotechnology - Abstract
Hybrid rice Fanyou 7206 (FY7206), derived from the cross between a sterile line Fanyuan A and a restorer line Fuhui 7206, was bred by the Rice Research Institute, Fujian Academy of Agricultural Sciences, China. FY7206 was characterized by moderate blast resistance, cold tolerance, as well as wide adaptability, and high yields. The blast resistance results indicated that the frequencies of blast races in race B, race C and the total resistance frequency for FY7206 were 95.5%, 100.0% and 97.2%, respectively. The disease resistance results showed that the leaf blast grade for FY7206 was level 1 and panicle blast was level 5. The indoor spray results indicated that FY7206 was resistant to 11 isolates of Magnorpathe oryzae . The blast resistance of FY7206 might be derived from the high expression of blast resistance gene Pid3 . The results for simulated cold resistance in an artificial climate chamber indicated that the cold tolerance for FY7206 was moderate at the booting and flowering stages. The cold tolerance results also indicated that FY7206 could be tolerant to temperatures as low as 10 °C at the seedling stage. The qRT-PCR results showed that the expression of cold tolerance gene Ctb1 in FY7206 was relatively high. These results suggested that FY7206 is a hybrid indica rice variety with good comprehensive characteristics, including blast resistance and cold tolerance.
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185. Random-telegraph-noise-enabled true random number generator for hardware security.
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Brown, James, Zhang, Jian Fu, Zhou, Bo, Mehedi, Mehzabeen, Freitas, Pedro, Marsland, John, and Ji, Zhigang
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INTERNET of things , *INTERNET security , *RANDOM number generators , *COMPLEMENTARY metal oxide semiconductors , *ARTIFICIAL neural networks - Abstract
The future security of Internet of Things is a key concern in the cyber-security field. One of the key issues is the ability to generate random numbers with strict power and area constrains. "True Random Number Generators" have been presented as a potential solution to this problem but improvements in output bit rate, power consumption, and design complexity must be made. In this work we present a novel and experimentally verified "True Random Number Generator" that uses exclusively conventional CMOS technology as well as offering key improvements over previous designs in complexity, output bitrate, and power consumption. It uses the inherent randomness of telegraph noise in the channel current of a single CMOS transistor as an entropy source. For the first time multi-level and abnormal telegraph noise can be utilised, which greatly reduces device selectivity and offers much greater bitrates. The design is verified using a breadboard and FPGA proof of concept circuit and passes all 15 of the NIST randomness tests without any need for post-processing of the generated bitstream. The design also shows resilience against machine learning attacks performed by the LSTM neural network. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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186. Identification and Verification of Quantitative Trait Loci Affecting Milling Yield of Rice.
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Zhang, Hui, Zhu, Yu-Jun, Zhu, An-Dong, Fan, Ye-Yang, Huang, Ting-Xu, Zhang, Jian-Fu, Xie, Hua-An, and Zhuang, Jie-Yun
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RICE milling ,BROWN rice ,RICE yields ,GRAIN yields ,PADDY fields ,RICE quality - Abstract
Rice is generally consumed in the form of milled rice. The yield of total milled rice and head mill rice is affected by both the paddy rice yield and milling efficiency. In this study, three recombinant inbred line (RIL) populations and one F
4:5 population derived from a residual heterozygous (RH) plant were used to determine quantitative trait loci (QTLs) affecting milling yield of rice. Seven traits were analyzed, including recovery of brown rice (BR), milled rice (MR) and head rice (HR); grain yield (GY); and the yield of brown rice (BRY), milled rice (MRY) and head rice (HRY). A total of 77 QTLs distributed on 35 regions was detected in the three RIL populations. Four regions, where qBR5, qBR7, qBR10, and qBR12 were located, were validated in the RH-derived F4:5 population. In the three RIL populations, all the 11 QTLs for GY detected were accompanied with QTLs for two or all the three milling yield traits. Not only the allele direction for milling yield traits was unchanged, but also the effects were consistent with GY. In the RH-derived F4:5 population, regions controlling GY also affected all three milling yield traits. Results indicated that variations of BRY and MRY were mainly ascribed to GY, but HRY was determined by both GY and HR. Results also showed that the regions covering GW5–Chalk5 and Wx loci had major effects on milling quality and milling yield of rice. These two regions, which have been known to affect multiple traits determining grain quality and yield of rice, provide good candidates for milled yield improvement. [ABSTRACT FROM AUTHOR]- Published
- 2020
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187. Defect Losses under Different Processes, Stress, Recovery, and Anneal Conditions
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Duan, M., Zhang, Jian Fu, Ji, Z., and Zhang, W.
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It is well known that degradation limits device lifetime. Early works were focused on defect generation and it is generally believed that, once a defect is created, it will be there forever. Although some defects can be neutralized after stress, they will recharge when the stress is resumed. Recently, we show that the generated defects themselves are not stable and can be lost. In this work, we investigate defect losses on samples fabricated under different conditions and the loss after different stress, recovery, and anneal conditions. It is found that the defect losses are a generic phenomenon and occur in both plasma SiON and ALCVD SiON/HfSiON stack. It will be shown that the defect losses are insensitive to the level of neutralization during the anneal. The losses have been observed at a temperature as low as 125 oC.
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- 2013
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188. The protective effect of capsaicin receptor-mediated genistein postconditioning on gastric ischemia-reperfusion injury in rats.
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Du, Dong-Shu, Ma, Xiao-Bo, Zhang, Jian-Fu, Zhou, Xiao-Yan, Li, Yu, Zhang, Yong-Mei, and Qiao, Wei-Li
- Subjects
- *
GENISTEIN , *CAPSAICIN , *ISCHEMIA , *REPERFUSION injury , *REVERSE transcriptase polymerase chain reaction , *CALCITONIN gene-related peptide , *PHOSPHORYLATION , *LABORATORY rats , *ANIMAL experimentation , *BIOCHEMISTRY , *CARRIER proteins , *COMPARATIVE studies , *ENZYME inhibitors , *GENETIC techniques , *HETEROCYCLIC compounds , *PHENOMENOLOGY , *RESEARCH methodology , *MEDICAL cooperation , *RATS , *RESEARCH , *THERAPEUTICS , *EVALUATION research , *PHYTOESTROGENS , *CHROMONES , *PHARMACODYNAMICS , *PHYSIOLOGY - Abstract
Background: No published study has addressed the effect of genistein postconditioning on gastric ischemia-reperfusion (GI-R) injury in rats.Aim: To examine whether capsaicin receptor-mediated genistein postconditioning protects against gastric ischemia-reperfusion injury via the PI3K/Akt signal pathway.Methods and Results: Chloraldurat-anesthetized rats underwent occlusion of the celiac artery for 30 min, followed by 60 min of reperfusion. Based on this animal model of gastric ischemia-reperfusion injury, genistein at doses of 100, 500 or 1,000 μg/kg was administered via peripheral vein 5 min before reperfusion. The dose of 500 μg/kg was optimal for postconditioning, at which the severity of I-R-induced gastric injury significantly decreased. Immunohistochemistry also showed that gastric mucosal cell apoptosis decreased. Capsazepine (CPZ), a specific antagonist for the capsaicin receptor, was administered (1,000 μg/kg, i.v.) just before ischemia. Capsaicin (50 mg/kg, s.c.) once a day for 4 days reversed the protective effects of genistein. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting showed increased calcitonin gene-related peptide (CGRP) expression in genistein group but not in capsazepine or capsaicin group. CGRP inhibitor CGRP8-37 also prevented the effects of genistein in decreasing gastric mucosal injury index. In addition, PI3K inhibitor LY294002 (1.5 mg/kg) reversed the protective effect of genistein. Compared with genistein group, Western blots also demonstrated decreased Akt phosphorylation in LY294002 group.Conclusion: Our data suggest that capsaicin receptors mediated the protective effects of genistein postconditioning. CGRP secreted by activated capsaicin-sensitive neurons played an important role in the protective effects of genistein. PI3K/Akt pathway was also involved in the protective effects of genistein. [ABSTRACT FROM AUTHOR]- Published
- 2010
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189. Current rice production is highly vulnerable to insect-borne viral diseases.
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Wu, Jian-guo, Yang, Guo-yi, Zhao, Shan-shan, Zhang, Shuai, Qin, Bi-xia, Zhu, Yong-sheng, Xie, Hui-ting, Chang, Qing, Wang, Lu, Hu, Jie, Zhang, Chao, Zhang, Bao-gang, Zeng, Da-li, Zhang, Jian-fu, Huang, Xian-bo, Qian, Qian, Ding, Shou-wei, and Li, Yi
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RICE , *HYBRID rice , *VIRUS diseases , *FOOD crops , *RICE blast disease - Abstract
A total rice category of infection rate was conducted based on 528 varieties, including different rice types of I indica i , I japonica i , hybrid I indica i , hybrid I japonica i , restorer line, sterile line and maintainer line that were infected by SRBSDV, RBSDV and RGDV, respectively (Supplementary Fig. (B) The infection rate of 528 rice varieties upon RBSDV and RGDV infection under natural conditions. (A) The infection rate of hybrid rice, indica type and japonica type upon SRBSDV infection under greenhouse and natural conditions. [Extracted from the article]
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- 2022
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190. Synchrotron Intensity and Polarization Gradients: Tools to Obtain the Magnetization Level in a Turbulent Medium.
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Carmo, Lorena, González-Casanova, Diego F., Falceta-Gonçalves, Diego, Lazarian, Alex, Jablonski, Francisco, Zhang, Jian-Fu, Ferreira, Ivan, Castro, Manuel, and Yang, Bo
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SYNCHROTRON radiation , *MAGNETIZATION , *MACH number , *BAYESIAN analysis , *MAGNETIC fields - Abstract
Synchrotron intensity and polarization gradients (SIG and SPG), proposed by Lazarian et al. and Lazarian & Yuen, present a new way to recover the mean magnetic field direction in the plane of the sky. To measure the magnetization level, Lazarian et al. suggested that the methods used in the context of the "Velocity Gradient Technique" could also be used on the SIG and SPG contexts. In this work we test the two proposed methods, named "top-base" and the circular standard deviation, "S," to obtain the level of magnetization from synchrotron emission. In order to test the methods, we generate synthetic observations from magnetohydrodynamic computer simulations, with Alfvénic Mach numbers, MA ∈ [0.2,1.7]. Using a Bayesian analysis we find that the circular standard deviations for the SIG and SPG methods are able to recover the magnetization for cases with signal-to-noise ratio ≳5. We found that for weak Faraday depolarization and different angles between the magnetic field direction and the line of sight the magnetization level can still be estimated. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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191. Automated method of tracing proton tracks in nuclear emulsions.
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Ruan, Jin-lu, Li, Hong-yun, Song, Ji-wen, Zhang, Jian-fu, Chen, Liang, Zhang, Zhong-bing, Liu, Jin-liang, and Liu, Lin-yue
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NUCLEAR emulsions , *NEUTRON sources , *MICROSCOPES , *IMAGE processing , *SPECTRUM analysis - Abstract
The low performance of the manual recognition of proton-recoil tracks in nuclear emulsions has limited its application to energy spectrum measurement of a pulsed neutron source. We developed an automated microscope system to trace proton-recoil tracks in nuclear emulsions. Given a start point on the proton track of interest, the microscope system can automatically trace and record the entire track using an image processing algorithm. Tests indicate that no interaction of the operator is needed in tracing the entire track. This automated microscope greatly reduces the labor of the operator and increases the efficiency of track data collection in nuclear emulsion. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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192. The effect of Phloretin on human γδ T cells killing colon cancer SW-1116 cells
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Zhu, Sheng-Ping, Liu, Gang, Wu, Xiao-Ting, Chen, Fu-Xing, Liu, Jun-Quan, Zhou, Zhong-Hai, Zhang, Jian-Fu, and Fei, Su-Juan
- Subjects
- *
PHLORETIN , *COLON cancer diagnosis , *T cells , *ISOPENTENYL-diphosphate isomerase , *LACTATE dehydrogenase , *FLOW cytometry , *GRANZYMES , *WESTERN immunoblotting - Abstract
Abstract: Objective: To explore the effect and mechanism of Phloretin on human γδ T cells killing colon cancer SW-1116 cells. Methods: γδ T cells were amplified in vitro from human peripheral blood mononuclear cells through isopentenyl pyrophosphate method (IPP). After cocultured different concentrations of Phloretin with γδ T cells or SW-1116 cells for 48h respectively, MTT assay was used to test the growth curve of these two cells; Flow cytometry to test the expression of Granzyme B (GraB), perforin (PFP), CD107a and IFN-γ of γδ T cells; Lactate dehydrogenase (LDH) release assay to test the cytotoxic activity of the γδ T cells on SW-1116 cells; and Western blot to test the Wnt3a expression of the γδ T cells. Results: After cultured with IPP for ten days, the percentage of γδ T cells increased from 3.31±3.00% to 78.40±10.30%. Compared to the control group, when the concentration of Phloretin increased from 2.35μg/ml to 18.75μg/ml, it could significantly proliferate the γδ T cell growth (P <0.05) and inhibit the growth of SW-1116 cells in dose–response, and the expression of GraB, PFP, CD107a and Wnt3a significantly increased (P <0.05). Significant positive relationships were observed among CD107a and PFP, GraB, cytotoxicity (P <0.05). The percentage of IFN-γ producing γδ T cells treated with Phloretin was significantly higher than control group. Conclusion: Phloretin can enhance the killing effect of γδ T cells on SW-1116 cells; the mechanism may be that Phloretin could proliferate the γδ T cell growth, increase the expression of PFP and GraB, activate the Wnt signaling pathway, and produce higher level of IFN-γ. Indeed CD107a expression probably correlates quite well with antitumor activity. [Copyright &y& Elsevier]
- Published
- 2013
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193. Identification of the STAT5B-RARα fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, c-Kit and C/EBPα mutation.
- Author
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Qiao, Chun, Zhang, Su-Jiang, Chen, Li-Juan, Miao, Kou-Rong, Zhang, Jian-Fu, Wu, Yu-Jie, Qiu, Hai-Rong, and Li, Jian-Yong
- Subjects
- *
CASE studies , *IN situ hybridization , *CHROMOSOME abnormalities , *ACUTE leukemia , *GENES - Abstract
T(15;17) is the most common chromosomal aberration in patients with acute promyelocytic leukemia (APL), leading to the formation of PML-RARα fusion gene. In a small subset of patients with APL, the RARα gene is fused with different partners. Here, we report a rare APL case with STAT5B-RARα fusion transcript. Cytomorphologic and immunophenotypic analyses showed typical features of APL. However, cytogenetic analysis showed normal karyotype, and interphase fluorescence in situ hybridization (FISH) showed PML-RARα negative. Quantitative RT-PCR also showed PML-RARα negative but STAT5B-RARα positive and sequencing analysis confirmed the result. Molecular markers including FLT3, NPM1, c-Kit and C/EBPα mutation were all negative. To our knowledge, this is the first APL patient with STAT5B-RARα in Chinese population and the fifth patient around the world according to published paper. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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194. The protective effect of 17β-estradiol postconditioning against hypoxia/reoxygenation injury in human gastric epithelial cells
- Author
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Liu, Mei-Jing, Fei, Su-Juan, Qiao, Wei-Li, Du, Dong-Shu, Zhang, Yong-Mei, Li, Yu, and Zhang, Jian-Fu
- Subjects
- *
ESTRADIOL , *HYPOXEMIA , *EPITHELIAL cells , *GASTRIC acid , *SUPEROXIDE dismutase , *ESTROGEN receptors , *APOPTOSIS - Abstract
Abstract: The purpose of this study was to investigate the effects and mechanisms of 17β-estradiol pharmacological postconditioning on gastric epithelial cells hypoxia/reoxygenation injury by using an in vitro model of human gastric epithelial cells. The model of hypoxia/reoxygenation was established with human gastric epithelial cell line. The gastric epithelial cell viability was detected by 3-(4, 5-dimethylthazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assays. Gastric epithelial cellular apoptosis was determined by Hoechst 33258 fluorochrome staining and flow cytometric analysis. Contents of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were measured by Colorimetry analysis. The protein expression of Bcl-2 and Bax in different groups was determined by Western blot analyses and immunocytochemistry assay. 17β-estradiol (10−8, 10−7 and 10−6 mol/l) inhibited hypoxia/reoxygenation injury and 17β-estradiol (10−6 mol/l) obviously attenuated hypoxia/reoxygenation injury 3h hypoxia followed by 4h reoxygenation. 17β-estradiol promoted gastric epithelial cell viability and inhibited the gastric epithelial cell apoptosis, and meanwhile, decreased the MDA content and increased SOD activity. The level of Bcl-2 protein was restored to the normal level by 17β-estradiol pharmacological postconditioning. In contrast, the Bax protein level was markedly reduced by 17β-estradiol pharmacological postconditioning. These effects of 17β-estradiol were inhibited by pretreatment with fulvestrant. These data suggested that 17β-estradiol seems involved in regulation of gastric hypoxia/reoxygenation injury and gastroprotection, and its protective effects were strongly related to estrogen receptor. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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195. EXTRACELLULAR SIGNAL-REGULATED KINASE PATHWAYS MAY MEDIATE THE PROTECTIVE EFFECT OF ELECTRICAL STIMULATION OF THE PARAVENTRICULAR NUCLEUS AGAINST ISCHAEMIA–REPERFUSION INJURY OF THE GASTRIC MUCOSA.
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Zhang, Yong-Mei, Wei, Er-Qing, Li, Li, Qiao, Wei-Li, Wang, Lin, and Zhang, Jian-Fu
- Subjects
- *
PROTEIN kinases , *GASTRIC mucosa , *APOPTOSIS , *IMMUNOHISTOCHEMISTRY , *ISCHEMIA , *BLOOD circulation disorders , *REPERFUSION - Abstract
1. The aim of the present study was to elucidate the role of the extracellular signal-regulated kinase (ERK) pathway in mediating the effects of electrical stimulation of the paraventricular nucleus (PVN) on apoptosis and proliferation induced by gastric ischaemia–reperfusion injury (GI/RI). 2. To investigate the effects of electrical stimulation of the hypothalamic PVN on gastric mucosal apoptosis and proliferation in response to ischaemia–reperfusion (I/R), we used a GI/RI model by clamping the coeliac artery for 30 min and then reperfusing the artery for 30 min or 1, 3 or 6 h. We used immunohistochemistry and western blotting to investigate the expression, activation and distribution of ERKs and the dynamic changes in their downstream cellular factors Bcl-2 and Bax at different times subsequent to electrical stimulation of the PVN in the I/R-injured gastric mucosa. 3. Electrical stimulation of the PVN markedly attenuated GI/RI at 30 min and 1 and 3 h after reperfusion. Electrical stimulation decreased gastric mucosal apoptosis, increased gastric mucosal proliferation and promoted the expression and activation of phosphorylated (p)-ERK1/2 30 min after reperfusion. Electrical stimulation increased the expression of Bcl-2 and decreased the expression of Bax at 30 min and 1 and 3 h after reperfusion. In contrast, inhibition of ERK1/2 activity by the specific upstream mitogen-activated protein kinase kinase inhibitor PD98059 produced similar effects at 1 h after reperfusion in rats subjected to I/R with or without electrical stimulation of the PVN. Administration of PD98059 aggravated gastric mucosal injury, increased apoptosis, decreased proliferation in gastric mucosal cells, decreased the expression and activity of p-ERK1/2 and Bcl-2 expression and increased Bax expression. 4. These results indicate that the PVN protects against GI/RI and that this protection is associated with the inhibition of cellular apoptosis and the promotion of proliferation in the gastric mucosa, probably by activating the ERK pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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196. Extracellular signal-regulated kinase 1- and 2-mediated gastric mucosal injury and repair in gastric ischemia-reperfusion of rats.
- Author
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Qiao WL, Wang L, Zhang YM, Zhang JF, Wang GM, Qiao, Wei-Li, Wang, Lin, Zhang, Yong-Mei, Zhang, Jian-Fu, and Wang, Guang-Ming
- Abstract
Background: The current study was undertaken to investigate the time course of gastric ischemia-reperfusion (GI-R)-induced gastric mucosal injury and repair and whether extracellular signal-regulated kinase 1/2 (ERK1/2) were involved in GI-R-induced gastric mucosal injury and repair.Methods: Immunohistochemistry and Western blot analyses were used.Results: Gastric mucosal injury induced by ischemia alone was mild. However, the injury worsened after reperfusion, reaching a maximum at 1 h, and was accompanied by increased apoptotic cells and decreased proliferative cells. Then, the gastric mucosal cells began to repair the injury by enhanced proliferation, which peaked at 24 h after reperfusion, and by 72 h the damaged gastric mucosa was mostly repaired. The ERK1/2 (nonactivated ERK1/2) protein expression level and distribution profile showed no significant changes during the entire reperfusion phase, but the p-ERK1/2 (activated ERK1/2) level changed dramatically. The p-ERK1/2 protein level was decreased at 0.5 h after reperfusion began, and then gradually increased, peaking after 3 h of reperfusion; these changes in p-ERK1/2 occurred simultaneously in the cytoplasm and nucleus. On the other hand, inhibition of the activation of ERK1/2, induced by PD98059, a specific ERK1/2 upstream inhibitor, aggravated the gastric mucosal injury, and apoptosis was increased and proliferation was reduced in the gastric mucosal cells after the same duration of reperfusion.Conclusions: Serious gastric mucosal damage involving apoptotic cells occurred rapidly at an early stage of reperfusion and was closely related to the suppression of ERK1/2 activation. The activated ERK1/2 signaling transduction pathway played an important role. Activated ERK1/2 participated in the regulation of gastric mucosal injury and repair induced by GI-R, and might be mediated by the inhibition of apoptosis and the promotion of proliferation in gastric mucosal cells. [ABSTRACT FROM AUTHOR]- Published
- 2006
197. Porous Ni-Mo bimetallic hybrid electrocatalyst by intermolecular forces in precursors for enhanced hydrogen generation.
- Author
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Pan, Qing-Qing, Xu, Chun-Yan, Li, Xiao, Zhang, Jian-Fu, Hu, Xiao-Li, Geng, Yun, and Su, Zhong-Min
- Subjects
- *
INTERMOLECULAR forces , *BIMETALLIC catalysts , *INTERSTITIAL hydrogen generation , *PRECIOUS metals , *HYDROGEN evolution reactions , *HYDROGEN as fuel , *CATALYSTS , *CATALYTIC activity - Abstract
A low-cost porous bimetallic hybrid electrocatalyst (Ni/Mo 6 Ni 6 C@C nanoparticle) has been synthesized via a soft-template using Polyethylenimine (PEI), Polyoxometalate (POM) and metal ion as precursors. • The bimetallic catalysts Ni/Mo 6 Ni 6 C@C were synthesized by a soft-template method. • The intermolecular forces in precursors are the basis of forming Ni/Mo 6 Ni 6 C@C. • Ni/Mo 6 Ni 6 C@C exhibited excellent catalytic activity and durability for HER. • DFT calculations pinpoint the origin of the excellent performance of Ni/Mo 6 Ni 6 C@C. Hydrogen generated by water splitting devices is a promising way to solve energy issues, which is limited by Pt-based precious catalysts. Developing efficient Pt-free electrocatalyst for hydrogen evolution reaction (HER) is highly essential for the practical applications. Herein, we report a soft-template method to fabricate an efficient porous bimetallic hybrid material, dubbed Ni/Mo 6 Ni 6 C@C. Benefiting from the bimetallic feature and porous structure, Ni/Mo 6 Ni 6 C@C exhibits low overpotentials of 101 and 122 mV at 10 mA cm−2 with robust stability in alkaline and acidic media, respectively. Theoretical calculations demonstrate that the C sites of the Mo 6 Ni 6 C possess the most excellent electrocatalytic activity due to its Gibbs free energy of hydrogen adsorption closer to 0 eV. Moreover, the superior stability, metallic character and mechanical property are characterized by first-principles calculations, which are advantageous for the Mo 6 Ni 6 C to be the HER catalyst. This study supplies a concise strategy to prepare the highly efficient bimetallic electrocatalyst for HER. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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198. Protective effect of microinjection of glutamate into hypothalamus paraventricular nucleus on chronic visceral hypersensitivity in rats.
- Author
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Su, Zhen, Miao, Bei, Xu, Man-qiu, Yang, Min-jie, Fei, Su-juan, and Zhang, Jian-fu
- Subjects
- *
PARAVENTRICULAR nucleus , *MICROINJECTIONS , *GLUTAMIC acid , *VASOPRESSIN , *SOLITARY nucleus - Abstract
• We found that glutamate stimulation of PVN reduced visceral sensitivity in the CVH rats. • We clarified that chemical ablation of PVN or NTS reversed the effect of PVN on CVH. • The microinjection of AVP-V 1 receptor antagonist DPVDAV into NTS promoted CVH. • The vagal nerve is participated in the CVH process. • We first reported that PVN and NTS are involved in the regulation of CVH. Chronic visceral hypersensitivity (CVH) is a major pathophysiological feature of patients experiencing in irritable bowel syndrome (IBS) and other disorders with visceral pain. However, little is known about its regulation of the central nucleus. In this research, we investigated the protective effect of microinjection of glutamate into hypothalamus paraventricular nucleus (PVN) on CVH and its possible regulatory mechanism in rats. Visceral sensitivity was assessed by pain threshold, abdominal withdrawal reflex (AWR) score, and the abdominal external oblique muscle electromyography (EMG) amplitude. Pathological changes in colorectal mucosa were assessed using immunohistochemical, biochemical analysis and Western blot. Results showed that microinjection of different doses of glutamate into PVN reduced the visceral sensitivity in a dose-dependent manner. This effect can be reversed after chemical ablation of PVN or nucleus tractus solitarius (NTS) or pretreatment with the arginine vasopressin (AVP)-V 1 receptor antagonist ([Deamino-pen1,val4,D-Arg8]-vasopressin) DPVDAV into NTS. The vagus discharge frequency was significantly reduced after the glutamate microinjection into PVN. Additionally, oxidation, proliferation and apoptosis in colorectal mucosa were related to the CVH regulations. These findings suggested that PVN and NTS are involved in the regulatory process of CVH and exert the protective effect on CVH, providing new ideas and therapeutic targets for CVH research. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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- View/download PDF
199. RTN in GexSe1-x OTS selector devices.
- Author
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Chai, Zheng, Zhang, Weidong, Degraeve, Robin, Zhang, Jian Fu, Marsland, John, Fantini, Andrea, Garbin, Daniele, Clima, Sergiu, Goux, Ludovic, and Kar, Gouri Sankar
- Subjects
- *
BURST noise , *RANDOM noise theory - Abstract
Random telegraph noise (RTN) signals in Ge x Se 1-x ovonic threshold switching (OTS) selector have been analysed in this work, both before and after the first-fire (FF) operation and at on- and off-states. It is observed that RTN appears after the FF, and its absolute amplitude at the off-state is small and negligible in comparison with the RTN signals in RRAM devices. At the on-state, large RTN signals are observed, which can either partially or fully block the conduction path, supporting that a conductive filament is formed or activated by FF and then modulated during switching. Statistical analysis reveals that the relative RTN amplitude at on-state in Ge x Se 1-x OTS selector is smaller than or equivalent to those in RRAM devices. Unlabelled Image • Random telegraph noise signals are analysed in Ge x Se 1-x ovonic threshold switching (OTS) selector. • RTN appears after first-fire, with small absolute amplitude at the off-state, and is negligible in 1S1R operation. • On-state RTN is larger and can either partially or fully block the conduction path • Relative RTN amplitude at on-state in OTS is smaller than or equivalent to that in RRAMs [ABSTRACT FROM AUTHOR]
- Published
- 2019
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- View/download PDF
200. [The Expression Level and Diagnostic Value of Serum Free Light Chain in B-Cell Non-Hodgkin Lymphoma].
- Author
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Wang Y, Wang H, Zhang JF, Li JY, Zhang NH, and Wang R
- Subjects
- Humans, Retrospective Studies, Immunoglobulin Light Chains, Lymphoma, B-Cell diagnosis
- Abstract
Objective: To investigate the expression level and the diagnostic value of serum free light chain in B-cell non-Hodgkin's lymphoma (B-NHL)., Methods: We retrospectively analyzed the results of serum free light chain (sFLC) of 394 newly treated B-NHL patients in our hospital from January 2014 to December 2021 and compared the secretion levels of sFLC among different subtypes of B-NHL. The value of sFLC secretion levels in the diagnosis of WM was evaluated using ROC., Results: Increased proportion of sFLC, abnormal ratio of sFLC (κ / λ) and the secretion levels of sFLC (κ+λ) were different in different B-NHL subtypes, Waldenstrom's macroglobulinemia (WM) had the highest proportion of elevated sFLC(82.68%) and abnormal sFLC(κ/ λ)(87.0%), the proportion of FL(18.0%) and DLBCL patients(12.8%) with elevated sFLC was lower ( P <0.05). The expression levels of sFLC can helpful in the diagnosis of WM (AUC=0.874, P <0.001, 95% CI : 0.779-0.970). At the same time, higher sFLC levels and sFLC cloning patterns predicted the possibility of bone marrow infiltration of lymphoma., Conclusion: The serum free light chains is common in patients with B-NHL. The elevated level and type of free light chain are associated with the type of lymphoma, and the patients with bone marrow infiltration have higher sFLC(κ+ λ) expression level.
- Published
- 2023
- Full Text
- View/download PDF
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