201. Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases.
- Author
-
Harada A, Mukaida N, and Matsushima K
- Subjects
- Animals, Chemokines immunology, Disease Models, Animal, Humans, Interleukin-8 chemistry, Molecular Structure, Inflammation immunology, Interleukin-8 immunology, Signal Transduction immunology
- Abstract
Aberrant production of interleukin 8 (IL-8) has been shown in various human inflammatory diseases. Recent investigations in animal models using either blocking antibodies against IL-8 or disruption of the gene encoding the IL-8 receptor have revealed the involvement of IL-8 in the recruitment of neutrophils and in neutrophil-associated tissue injury in acute inflammation. These studies suggest that IL-8 is a novel target to alleviate acute inflammation. This review describes the properties of IL-8 and discusses different therapeutic approaches to target IL-8, particularly the use of humanized monoclonal antibodies against IL-8 and inhibition of IL-8 gene transcription.
- Published
- 1996
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