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Amides are one of the most important classes of compounds that widely exist in bioactive molecules such as peptides and alkaloids. They also have important applications in various fields such as chemical engineering, dyes and pharmaceutical development. Therefore, studying the synthesis and structural identification of amide compounds is of great significance. Due to the delocalization of lone pair electrons from the nitrogen atom of amide compounds to the carbonyl group (C＝O), the C―N bond in the amide RCO―N exhibits partial double bond properties, preventing free rotation and resulting in complex nuclear magnetic resonance hydrogen spectrum (¹H NMR). This article summarizes the characteristics of ¹H NMR spectra of amides and discusses some factors influencing amide isomerization. This article will cultivate students' ability to analyze the 1H NMR of amides and deepen their understanding and knowledge of amide compounds. [ABSTRACT FROM AUTHOR]

This study provides an in-depth understanding of the islands and sandbars within the Xisha Islands, located in the South China Sea, with the aim of distinguishing them based on different geological, ecological, and historical features. The changes in the marine ecosystem and the conservation measures taken to maintain the rich biodiversity of the archipelago are also explored. The main objective of this study was to differentiate islands and sandbars based on geological, ecological, and historical criteria and to examine the period of formation, geological features, and altitudinal characteristics of these terrains. The dynamic characteristics of sandbars were explored as the basis of island formation by focusing on their sensitivity to external environmental factors and assessing the presence of vegetation and human activities. The overall implications of these findings for marine life and conservation efforts on the Paracel Islands were analyzed. To achieve these objectives, geological investigations, historical documentation, and ecological assessments were combined. Key methods included geochronological analysis to date the formation of the islands and sandbars, assessment of elevation and geological composition to analyze the vegetation cover on these terrains, and a review of the historical documentary record to gain insights into human activities and investigate the marine ecosystem and its biodiversity. The geological studies revealed that islands are usually formed over a long period of time (approximately 4,000 years or more) and above the water surface, with beach rocks formed around them and a large amount of coral detritus accumulating on the embankment, which in turn forms a sand dike encompassing the dyke and the coastline. This protects the embankment and coastline, making the island expand in size, increase in elevation slowly and become more stable, and the landscape less susceptible to deformation. In contrast, sandbars are relatively young (within the last 3,000 years) and low in elevation, are often inundated at high tides, and are more dynamic, including accretion and erosion, making them vulnerable to environmental changes. Vegetation grows on these islands and sandbars and planted vegetation is a prominent feature. Increased vegetation cover enhances the stability, height, and area of these terrains and plays a vital role in ecological conservation. This study also presents findings on the overall declining trend in marine organisms such as corals, sea turtles, and seabirds in the Xisha Islands, the causes of which are mainly related to anthropogenic (e. g., fishing) and natural (e. g., climatic causes such as typhoons and biological causes such as reduction in food availability) factors. In addition, the Government of Sansha Municipality (a special administrative region overseeing the Xisha Islands) in China has implemented the following measures: artificially cultivating marine plants, setting up marine life protection stations, establishing marine life nature reserves, and stepping up the fight against illegal hunting, which are examples of a series of effective measures that emphasize the need to strengthen comprehensive conservation measures in the face of increasingly severe environmental challenges. This study helps understand the geological and ecological characteristics of the Xisha Islands and provides an important reference for ongoing marine conservation efforts. This methodology for distinguishing between islands and sandbars based on different criteria lays the foundation for further research on biodiversity and environmental changes in the area. In addition, this study highlights the importance of maintaining fragile ecosystems in the face of mounting environmental challenges. Overall, this comprehensive study of the islands and sandbars of the Paracel Islands highlights the dynamic nature of these terrains, the influence of vegetation on their stability, and the need to strengthen integrated measures for marine conservation efforts in the South China Sea. [ABSTRACT FROM AUTHOR]

AIM: To observe how total flavonoids of Pterocarya hupehensis Skan （PHSTF） affects the migration and invasion of human rheumatoid fibroblast-like synoviocyte line MH7A. METHODS: The MH7A cells were divided into control group（ without any treatment）, low-, medium- and high-dose（ 6. 25, 12. 5 and 25 mg/L, respectively） PHSTF groups, phosphatidylinositol 3-kinase（ PI3K） inhibitor 740Y-P（ 10 μmol/L） group, and 740Y-P（ 10 μmol/L）+high-dose （25 mg/L） PHSTF group. The viability of the MH7A cells was determined by CCK-8 assay, while the migration and invasion were assessed by scratch and Transwell assays. The protein levels of matrix metalloproteinase-2 （MMP-2）, MMP-9, PI3K, p-PI3K, AKT and p-AKT were detected by Western blot. RESULTS: Compared with control group, the cell viability in PHSTF treatment groups was reduced （P<0. 05）, the cell wound healing area was significantly decreased （P< 0. 01）, migratory and invasive cells in the lower chamber were significantly reduced （P<0. 01）, and the protein expression of MMP-2 and MMP-9 and the ratios of p-PI3K/PI3K and pAKT/AKT were decreased（ P<0. 01）. Compared with highdose PHSTF group, the addition of PI3K/AKT pathway agonist 740Y-P significantly increased the migration and invasion ability of MH7A cells （P<0. 01） and elevated the protein expression of MMP-2 and MMP-9 and the ratios of p-PI3K/PI3K and pAKT/AKT （P<0. 01） under the treatment with PHSTF. CONCLUSION: Total flavonoids of Pterocarya hupehensis Skan could inhibit the migration and invasion of MH7A cells by regulating the PI3K/AKT signaling pathway. [ABSTRACT FROM AUTHOR]

In order to investigate the ability of the attitude controller of a quadcopter unmanned aerial vehicle(UAV) to possess strong target value tracking and resistance to external disturbances, a design for a quadcopter UAV attitude controller based on a reference model using deep deterministic policy gradients was proposed. The proposed method employed a neural network to directly map the state of the quadcopter unmanned aerial vehicle to its output. The reinforcement learning algorithm utilized in the paper was a combination of deep deterministic policy gradient (DDPG) and deep neural networks. In the structure of the DDPG algorithm, a reference model was further incorporated to mitigate system overshoot caused by excessive control inputs, stability and robustness of the system was enhanced. Moreover, modifications were made to the composition of rewards in reinforcement learning, The steady-state error of the system was successfully eliminated. The results show that this control method exhibits strong robustness in both target value tracking and resistance to external disturbances. It is concluded the controller performs better in terms of target value tracking and interference immunity compared to conventional controllers. [ABSTRACT FROM AUTHOR]

Birefringent compounds are widely used in engineering and researching fields like optical fiber. The electronic structures and birefringences of the post-transition metal halides PbX2 and BiX3(X=Cl, Br, I) were investigated by first-principles methods. The results show that the stereochemical activity of cations in PbX2 and BiX3(X=Cl, Br, I) decreases gradually from Cl to I. The stereochemical activity of the cation is determined by the energy level difference of the cation s orbital and the halogen p orbital. The greater the difference in energy levels, the weaker the degree of stereochemical activity of lone pair electrons. The cation p states nearby the Fermi level mainly determine the birefringence, which make the birefringence of PbX2 and BiX3(X=Cl, Br, I) gradually increase from CI to I. [ABSTRACT FROM AUTHOR]

新医科背景下的医学人才培养关系到“健康中国”战略目标的实现。虚拟仿真实验教学 作为培养医学生专业技能的重要手段，应从教学理念、课程体系、专业结构、考核评价等方面进行 改革，并形成功能结构完善的实验教学平台。研究从系统架构、实验教学体系、平台管理体系和实 验教学新模式四大方面明晰了医学虚拟仿真实验教学平台的建设路径，并从建立项目准入机制、 统一身份认证、资源有偿共享、校企合作机制四个方面为平台的可持续发展和共享应用提出了具 体措施，为新医科人才的培养注入力量。 [ABSTRACT FROM AUTHOR]

In order to comprehensively analyze the tobacco planting soil properties in the runoff area of Fuxian Lake, 154 soil samples were collected and analyzed from different towns, plot types and altitudes, and cluster analysis was conducted for different towns. The results showed that the pH of tobacco planting soil in the runoff area of Fuxian Lake was suitable as a whole, the content of hydrolyzed nitrogen was moderate, the content of phosphorus and potassium was rich, the content of organic matter was medium and low, the content of trace element boron was suitable, and the content of chloride ion was low. The content of P and K in Qinglong Town was 50 and 400 mg/kg respectively, which was sig- nificantly different from that in other towns. The content of hydrolyzed nitrogen and pH in Yousuo Town were higher. From the different field types, the differences of available phosphorus and hydrolyzed nitrogen contents of tobacco planting soil in dam area and mountain area reached significant level, while the contents of available potassium,pH, organic matter, available boron and chloride ion were not significant. The con- tents of available phosphorus, hydrolyzed nitrogen, pH and chloride ion in tobacco planting soil in dam area were higher than those in mountain area. From different altitudes, the contents of available phosphorus, available potassium and hydrolyzed nitrogen were higher at 1400-1600m, which were significantly different from other altitudes, and had a decreasing trend with the increase of altitude. There was no significant differ- ence in pH, organic matter and available boron among different altitudes. The organic matter increased with the elevation, while the available boron decreased with the elevation. The results showed that the soil properties in the runoff area of Fuxian Lake were more suitable for tobacco planting, but there were great differences in different towns and fields, and the coefficient of variation of individual indexes was large. There- fore, it is necessary to pay attention to the method of fine fertilization in tobacco production, so as to achieve "one piece, one scheme", in order to obtain high-quality tobacco leaves and environmental protection. [ABSTRACT FROM AUTHOR]

Gingival mesenchymal stem cells (GMSCs) cell clusters and functional heterogeneity were analyzed through single cell RNA sequencing technology. Human GMSCs were isolated and cultured in vitro, GMSCs were sequenced by 10× scRNA-Seq platform. The cells were grouped according to the gene expression differences, and analyze the expression of surface markers and cell cycle differences in each cluster. Differences in gene expression and gene expression profile of osteogenic, lipogenic and chondrogenic differentiation were compared，and the interactions between different clusters of cells were also analyzed. Human GMSCs were successfully extracted and grew in a vortex like manner. The GMSCs were composed of 9 cell clusters. ENG, NT5E, THY1, ITGB1 and CD44 were highly expressed, and CD34, CD14, PECAM1 and PTPRC were negatively expressed. The proportion of G2/M phase of GMSCs was 41.59%. The G2/M phase ratio of cell cluster 6 was the lowest (16.44%), while the cell cluster 2 was the highest with 99.08%. The expressions of adipogenic, chondrogenic and osteoblastic differentiation related genes were not identical in the 9 cell clusters. Nine clusters had different gene expression profiles, and 2/4 cell clusters showed high similarity, with relatively high expressions of TOP2A, UBE2C, KPNA2, CENPF genes. DKK1, KRT7 and ID1 genes were highly expressed in the cell cluster 5. MALAT1, FN1 and NEAT1 genes were highly expressed in the cell cluster 9. Moreover, GO analysis showed that each cell cluster enriched different pathways. The communication between cell cluster 9 and other cell clusters were the most active. The single-cell level study suggests that there are different functional clusters of GMSCs, and the proliferation capacity and genomic expression profile of each cluster were heterogeneous. [ABSTRACT FROM AUTHOR]

Stress cardiomyopathy (SC) is an acute cardiomyopathy caused by intense mental stimulation or physical stress. Currently, few interventions are effective in reducing mortality, improving prognosis, or preventing recurrence in acute or chronic stages of SC. Therefore, it is particularly important to establish a reliable and effective SC animal model to study the pathogenesis and prevention of SC. In this paper, the preparation methods and evaluation indexes of SC models at home and abroad were reviewed, including the operation details of catecholamine hormone injection method, binding method, binding combined with electroshock method, binding combined with dehydration method, vagus nerve electrical stimulation and other modeling methods, as well as evaluation indexes such as open field test, cardiac ultrasound, electrocardiogram and ELISA, striving to provide useful reference for model selection and establishment of SC research. [ABSTRACT FROM AUTHOR]

Taking cadmium telluride thin film solar cells as the research object, we have summarized re- cent advances towards the separation process for recovering tellurium from photovoltaic waste based on different types of separation techniques, including secondary utilization method, leaching method, adsorption method, membrane separation method and electrochemical method. The effects of various tellurium separation materials and tellurium separation processes on separation efficiency are then discussed, followed by a brief summary and outlook for tellurium process of photovoltaic waste to provide theoretical gist for other emerging electronic waste recycling. [ABSTRACT FROM AUTHOR]

改善高校毕业生就业工作一直是难点和热点。面对这一现状, 复旦大学附属儿科医院围绕历届毕业生职业发展情况, 以高质量培养、高水平就业为目标, 创新医学研究生管理工作方法和实施路径, 形成“三位一体”协同育人格局, 构建新型“培养-就业”体系, 注重激发学生自我能动性, 保障医学研究生高水平就业, 并取得一系列就业工作实效。 [ABSTRACT FROM AUTHOR]

Objective To explore the correlation between age of Kasai portoenterostomy and early prognosis to provide references for timing of Kasai surgery in biliary atresia (BA) children. Methods Retrospective review was conducted for clinical data of hospitalized BA children from January 2019 to December 2021.General profiles (gender & operative age) and parameters of liver function, coagulation function and blood ammonia were collected. According to the jaundice clearance at 3 months post-operation, they were assigned into two groups of non-jaundice clearance (n=47) and jaundice clearance (n=66).The cut-off value of operative age was calculated. Then two groups were divided according to operative age. The prognostic parameters of Kasai portoenterostomy at 3 months post-operation were compared, including alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), direct bilirubin (DBIL), postoperative DBIL/ preoperative DBIL, gamma-glutamyltransferase (GGT), total bile acid (TBA), total bilirubin (TBIL), platelet count (PLT), aspartate aminotransferase-to-platelet ratio index (APRI) and international normalized ratio (INR). Results A total of 113 cases were collected, including 49 males and 64 females. The operative age was 59.00 (40.50, 69.00) days. Univariate analysis of the preoperative indexes of the non-jaundice clearance group and the jaundice clearance group showed that the age of operation(64 (52, 79) d vs. 55 (33, 67) d), AST (202.00 (138.00, 332.00) U/L vs. 147.50 (100.00, 242.00) U/L), indirect bilirubin (IBIL) ((70.60±20.31)μmol/L vs. (79.96±27.13)μmol/L), total protein(TP) ((55.88±6.59)g/L vs. (53.13±4.71)g/L) between the two groups were statistically significant (P < 0.05). The indexes with P < 0.1 in univariate analysis [age of operation, albumin (ALB), ALT, AST, IBIL, TP, activated partial thromboplastin time(APTT)] were included in the multivariate Logistic regression analysis, and the results showed that the age of operation (OR=0.974, 95%CI: 0.951-0.997, P=0.030) was an independent factor influencing the jnundice clearance at 3 months after Kasai protoentrostomy. According to the cut-off value (46.5d) of the operative age group, the results showed that the levels of ALP(365.00 (316.00, 514.75) U/L vs. 492.00 (343.00, 684.00) U/L), ALT ((76.35±81.33) U/L vs. (134.09±97.45)U/L), AST (67.50 (41.50, 99.50) U/L vs. 112.00 (79.00, 168.00) U/L), DBIL (2.55 (1.78, 6.95) μmol/L vs. 9.80 (3.60, 36.80) μmol/L), postoperative DBIL/ preoperative DBIL(0.05 (0.03, 0.09) vs. 0.12 (0.05, 0.54)), TBA (45.50 (25.93, 92.93) μmol/L vs.106.20 (41.20, 187.50) μmol/L), TBIL (9.65 (6.98, 15.43) μmol/L vs. 21.50 (10.40, 66.90) μmol/L) and APRI (0.32 (0.22, 0.48) vs.0.62 (0.41, 0.93)) in the operation age ≤46.5 d group were significantly lower than those in the operation age > 46.5 d group, the difference was statistically significant (P < 0.05). Conclusion Early prognostic parameters are superior in group with operative age≤46.5 days to group with operative age >46.5 days. And early Kasai portoenterostomy may improve the prognosis of BA. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between serum brain natriuretic peptide (BNP), 25 hydroxyvitamin d [25 (OH) D], galactose lectin-3 (Gal-3) and left ventricular diastolic function in patients with hypertensive disorders of pregnancy (HDP), and to analyze its effect on pregnancy outcome. Methods: 114 patients with HDP who were treated in our hospital from June 2019 to December 2021 were selected as the study group, including 39 cases of gestational hypertension group, 44 cases of mild preeclampsia group and 31 cases of severe preeclampsia group. In addition, 30 healthy pregnant women examined in our hospital in the same period were selected as the control group. The serum BNP, 25(OH) D, Gal-3 and left ventricular diastolic function were compared in each group, and the correlation between serum BNP, 25 (OH) D, Gal-3 and left ventricular diastolic function were analyzed. According to the pregnancy outcome, the patients were divided into 65 cases in the good pregnancy outcome group and 49 cases in the poor pregnancy outcome group. The clinical data of the two groups were collected. The influencing factors of poor pregnancy outcome in patients with HDP were analyzed by univariate analysis and multivariate Logistic regression. Results: There were significant difference in the levels of serum BNP, 25 (OH) D and Gal-3 in each group (P<0.05). With the increase of disease severity, the levels of serum BNP and Gal-3 in patients with HDP gradually increased, and the level of 25 (OH) D gradually decreased. There were significant differences in the peak velocity of early diastolic filling (E peak), late diastolic filling (A peak) and E / A among the groups (P<0.05). Pearson correlation analysis showed that the levels of serum BNP and Gal-3 in patients with HDP were negatively correlated with E peak and E / A (P<0.05), and positively correlated with A peak (P<0.05), serum 25 (OH) D was positively correlated with E peak and E / A (P<0.05), and negatively correlated with A peak (P<0.05). Multivariate Logistic regression analysis showed that systolic blood pressure 158.02 mmHg, diastolic blood pressure 104.32 mmHg, serum BNP406.42 ng/L, serum 25 (OH) D 14.94 g/L and serum Gal-316.17 ng/mL were the risk factors of poor pregnancy outcome of HDP(P<0.05).Conclusion: The abnormal increase of the levels of serum BNP and Gal-3, and the abnormal decrease of the level of 25 (OH) D in patients with HDP are the risk factors of poor pregnancy outcome in patients with HDP. The levels of the three are related to the left ventricular diastolic function. The detection of the levels of the three is helpful to the clinical judgment of pregnancy outcome. [ABSTRACT FROM AUTHOR]

The development of information technology has promoted the generation of a new scientific research paradigm. Social sciences and humanities have gradually developed a data-driven research method in recent years. From the perspective of visualization, the current status of visualization applications in digital humanities was summarized from three levels, task, data, and application, through the analysis of papers at the digital humantites conference organized by alliance of digital humanities organizations. By analyzing different projects setup by different experts with different backgrounds, i.e., humanities, visualization, and art. The great potential of multidisciplinary cooperation to improve the quality of digital humanities plus visualization projects was revealed. The practice of Peking University in exploring this new paradigm of multidisciplinary cooperation in digital humanities plus visualization was shared, which included education in multidisciplinary, practice experience on promotion, and research experience in intelligent visualization. Finally, two ways for the future development of the interdiscipline between digital humanity and visualization were revealed, the cooperation between experts and the collaboration between humans and computers. [ABSTRACT FROM AUTHOR]

The “warnings” section in medicine instructions is an important part that all national drug regulatory agencies use to ensure drug safety. This paper sorted out 12 laws, regulations and guidelines related to the “warnings” of drug instructions in 6 representative countries in Europe, America, Oceania, and Asia, and compared their expression and format requirements to provide reference for the improvement of the “ warning” terms in the instructions of Chinese patent medicines. Technical Specification for Revision of Safety Information in the Marketed Chinese Patent Medicine Instructions- Warnings (T/ CACM 1370. 6-2021) provided enlightenment for revising and improving the instructions in terms of the problems such as incomplete labelling of the “warnings”. We explored the strategy of clinical pharmaceutical service based on “warning” terms, and proposed to carry out the whole process of clinical pharmaceutical service based on the principles of “ monitoring, follow-up research, and international reference", and provide the most direct medication guidance for physicians, pharmacists, nurses, and patients to ensure the safe and rational medication in clinical practices, and to improve the quality of clinical pharmaceutical care. [ABSTRACT FROM AUTHOR]

[Objective] With a view to providing reference for the management of phosphorus (P) and potassium (K) and environmental assessment in the orchard, the nutrient balance and the environmental risk of P and K in mango orchards under optimized and reduced application of chemical fertilizer were examined.[Method] Seven fertilization treatments were conducted: (i) No fertilization (control, NF), (ii) Sole application of basal organic fertilizer (control, CF), (iii) Constant furrow application of chemical fertilizer (A), (iv) Combined furrow application of organic-inorganic fertilizer (OS), (v) Constant furrow application of integrated water fertilizer (IWF), (vi) 30% Reduced furrow application of water fertilizer (RA), (vii) Combined application of organic-inorganic water fertilizer (OWF) . The surface runoff test was performed on the basis of rainfall simulation experiments, and estimations were made grounded on local meteorological data; The environmental risk assessment test of P and K was carried out in virtue of laboratory tests under simulated conditions to determine the threshold of environmental sensitivity of P and K, thereby dividing the scale; Nutrient balance was utilized to analyze the surplus and deficit of P and K.[Result] The surplus rate of P earned the highest ranking, up to 63.36% (67.04 kg/hhm²), in the constant furrow application of chemical fertilizer (A) ; Maximum K surplus was recorded in the furrow application of chemical fertilizer (A), with a rate of 49.49% (142.96 kg/hhm²) ; The runoff losses of P and K in mango orchards attained to 10.74 kg/hhm² and 8.86 kg/hhm² respectively. The P output and corresponding proportion was ranged as follows: Pruned branches and leaves > surface runoff > litter > harvested fruits, while the sequence of K output and corresponding proportion was: Harvested fruits > prune branches and leaves > litter > surface runoff. The risk threshold of P for a single input was 45.99 kg/hhm², and that of K reached 20.29 kg/hhm². The environmental risk of P in soil was calculated to be 103.78 mg/kg, and that of K arrived at 143.98 mg/kg. The available phosphorus contents of such treatments as A, OS, IWF and OWF exceeded the environmental risk threshold, signaling the phosphorus losses. Similarly, the potassium losses should be noted in that the available potassium contents in OWF and IWF topped the environmental risk threshold. The available potassium content in OS approached the environmental risk threshold, which suggested the potential risk of potassium losses. [Conclusion] (i) Remarkable improvements in the availability of soil potassium and the absorption of potassium by fruit trees can be achieved in virtue of combined application of organic fertilizer. (ii) Measures should be adopted to conserve soil and water in light of the large proportion of phosphorus runoff losses to the phosphorus input in orchards. (iii) Compared with other fertilization treatments, 30% reduced furrow application of water fertilizer (RA) embodies the most balanced input of P and K in general, as well as pockets of improvement. Hence a certain proportion of organic fertilizer instead of chemical fertilizer input is recommended. (iv) It is advisable to keep a single input of P no more than 45.99 kg/hhm² considering the lower demand of mango trees for phosphorus and make K input less than or equal to 20.29 kg/hhm² each time despite the great demand for potassium, and nutrients can be supplied with low amounts and high frequency. [ABSTRACT FROM AUTHOR]

Objective To compare PC-12 cells’apoptosis caused by the serotonin herbicides atrazine (ATR), simazine (SIM) and cyanazine (CYA). Methods The rat adrenal medullary pheochromoma PC-12 cell line was selected for routine culture. At the cell logarithmic growth phase, ATR, SIM and CYA were used at a concentration of 200 μmol/L for 24 h, respectively, and the same solvent was added in the control group. The CCK-8 method was used to detect the cell survival rate; the content of reactive oxygen species (ROS) in PC-12 cells was detected; the Real-time PCR and Western blotting methods were used to detect the mRNA and protein expressions of Bax, p53, Bcl-2 and Caspase-3. Results Compared with that in the control group， the survival rate of the cells in ATR group， SIM group and CYA group was significantly decreased. The intracellular ROS activity of the three groups was significantly increased, and the mRNA and protein expressions of Bax，p53 and Caspase-3 were increased. mRNA and protein expressions of Bcl-2 were significantly reduced （P<0. 01) . Compared with that in ATR group， the cell survival rate of SIM group and CYA group was significantly increased, the intracellular ROS activity of the two groups was significantly decreased， the expressions of Bax, p53 and Caspase-3 mRNA and protein were significantly reduced, and the expressions of Bcl-2 mRNA and protein were significantly increased (P<0. 01). Compared with that of SIM group， the cell survival rate of CYA group was significantly increased， while the intracellular ROS activity was significantly decreased; the Bax， p53 and Caspase-3 mRNA and protein expressions were significantly reduced， and Bcl-2 mRNA and protein expressions were significantly increased (P<0. 01）. Conclusion ATR，SIM and CYA can all promote PC-12 cells’apoptosis; ATR has the strongest effect while CYA has the weakest effect. [ABSTRACT FROM AUTHOR]

As an area with global significance and international influence on the common destiny of mankind, the no-polarity situation of the Arctic is gradually emerging under the coupling of multiple factors such as ecological environment, geopolitics, economic development and scientific and technological progress. The ecological environment in the Arctic region is interdependent and cooperative; geopolitics is the structure and reality of balance of power and win-win cooperation; economic development is the demand and expectation of shared responsibility and mutual benefit; scientific and technological progress is the model and vision of intellectual convergence and dynamic balance. The future of no-polarity Arctic governance needs to be considered from the aspects of value concept, international mechanism and leading force, and extensive and in-depth Arctic cooperation between China, the United States and Russia is needed. The construction of “Arctic community with shared future” is the development direction of no-polarity Arctic governance. [ABSTRACT FROM AUTHOR]

To investigate the efficacy of 3D laparoscopic radical gastrectomy for advanced gastric cancer and its effect on serum exosome Dicer and Phosphatase and tensin homolog deleted on chromosome ten (PTEN). A total of 60 patients with advanced gastric cancer treated in our hospital from July 2018 to May 2021 were selected as the research subjects. According to 1:1 random envelope lottery, the patients were divided into 3D group and laparotomy group, with 30 patients in each group. The open group was treated with open surgery, and the 3D group was treated with 3D laparoscopic radical gastrectomy. The surgical indications, complications, visual analog scales (VAS) score and Dicer and PTEN expressions of the two groups were compared and analyzed. There were no difference in the operation time and the number of lymph node dissections compared between the two groups(P>0.05). The postoperative exhaust time, postoperative gastric tube removal time, surgical incision length, the amount of bleeding, postoperative hospital stay, and surgery in the 3D group were less than that of the open group (P<0.05). The incidence of complications such as anastomotic bleeding, anastomotic leakage, gastroparesis, incision infection, and venous thrombosis in the 3D group at 14 days after operation were lower than the open group (P<0.05). The VAS scores of the 3D group at 1 d, 7 d and 14 d after operation were lower than those of the open group (P<0.05). The relative expression levels of serum exosomes Dicer and PTEN at 14 d after operation in the two groups were higher than that at 1d before operation (P<0.05), the 3D group were higher than the open group (P<0.05). All patients were followed up until November 1, 2021. The average follow-up time were (17.92± 0.22) months. The recurrence rate of the 3D group were 3.33 %, which were lower than the 20.00 % of the open group (P<0.05). 3D laparoscopic radical gastrectomy for patients with advanced gastric cancer can promote the secretion of serum exosome Dicer and PTEN without increasing the complexity of surgery, and can also promote the recovery of patients, reduce complications, relieve patients' pain, and reduce the recurrence rate during follow-up. [ABSTRACT FROM AUTHOR]

Focusing on the problem with traffic congestion under changing environmental conditions, this paper proposed a trajectory reward light (TR-light) model by combining reinforcement learning, neural network, multi-agent and traffic simulation technology to optimize the traffic at multi-intersections. This method had considerable merits in the following aspects. The traffic organization plan was formulated based on traffic lights; multi-agent reinforcement learning was used on traffic light control; regional traffic organization was optimized through the coordination of traffic lights; the agent implemented trajectory reconstruction after the execution of each behavior so as to change the vehicle travel path without changing the OD pair, and to calculate the final reward of the agent according to the plan and reconstructed trajectory. Finally, it conducted a traffic simulation experiment through SUMO. The comparison of traffic indicators verifies that the proposed model improves the smoothness of the road network and the traffic state at the multi-intersections. Experiments show that the model is feasible and effectively mitigates the traffic congestion. [ABSTRACT FROM AUTHOR]

Objective: The incidence of sleep disorders during pregnancy increases significantly compare to pre-pregnancy stage. Sleep disorders during pregnancy may lead to gestational diabetes, hyperglycemia, postpartum depression and other disease. This research is to study the effect that exercise during pregnancy can have on sleep disorders. Methods: A questionnaire survey was conducted on pregnant women who were treated in our hospital from January to March 2021. The general information, pregnancy status, living habits and exercise status of the pregnant women were collected. Based on the Pittsburgh Sleep Quality Index (PSQI), we are able to score the sleep quality of this group of pregnant women. After that, the group of women is split into 2 sub groups based on their daily average length of time spending on exercise: one with daily exercise time ≤ 30 minutes and the another with daily exercise time > 30 minutes; then to analyze the effect of exercise time during pregnancy on sleep quality. Pregnant women with sleep disorders received lifestyle modification instructions to increase the daily exercise time. After four weeks, we calculated the PSQI scores again. Results: Out of 320 questionnaires being distributed, 293 were being retrieved and proved to be valid. Among all of the 293 files, 238 fall into the category of average exercise time ≤ 30 minutes, and the average score on sleep quality is 5.88; on contrary, the rest 55 fall into the subgroup with exercise time > 30 minutes, whereat the score of sleep quality being 4.83. The difference in between of the two subgroups subject to the score on sleep quality are tested to be statistically significant. After increasing the time of exercise for pregnant women with sleep disorders, 24% of the subjects obtains improvement on their sleep quality. Conclusions: During pregnancy, pregnant women who exercise over 30 minutes on a daily basis are tended to have better sleep quality than those who exercise less than 30 minutes. Therefore, for those who experience sleep disorders during pregnancy, it is recommended for them to obtain more daily exercise (>30 minutes) in order to improve their sleep quality, thereby better off the perinatal outcome. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical characteristics and etiology of patients with chest pain and with normal coronary artery. Methods: From January 2019 to May 2021, 1283 patients who had chest pain and were suspected of coronary atherosclerotic heart disease and underwent coronary angiography in our hospital was retrospectively analyzed. Clinical datas such as the demographic data, risk factors were extracted and compared between patients with normal coronary angiography and abnormal normal coronary angiography. The etiology of chest pain in patients with normal coronary angiography was analyzed. Results: Finally, 91 patients with suspected coronary artery disease whose coronary angiography were generally normal were enrolled. Compared with 1192 patients with abnormal coronary angiography, 20.1% had no risk factor of cardiovascular diseases and 50.5% had a single high-risk factor in the normal coronary angiography group, which was significantly higher than the abnormal coronary angiography group. What's more, 28.6% patients had multiple risk factors in the normal coronary angiography group, which was significantly lower than that of the abnormal coronary angiography group(P<0.05). Among 91 patients suspected of coronary heart disease, 45 cases were cardiac neurosis(49.5%) and 12 cases were arrhythmia (13.2%). Conclusions: In clinical, many patients with chest pain have normal coronary angiography. Compared with patients with abnormal coronary arteries, these patients have fewer risk factors for coronary heart disease, the symptom of chest pain werecaused by other reasons, so we should emphasize the application of noninvasive examination methods in these patients. [ABSTRACT FROM AUTHOR]

Objective　To analyze the control effect and prognosis of Levetiracetam injection on convulsive epileptic status ( CSE), in order to promote its clinical application. Methods　A total of 80 CSE patients were enrolled in the Department of Neurology intensive Care Unit (NICU) of Qujing No.1 Hospital from September 2018 to April 2021. 40 patients in the Levetiracetam group (experimental group) and 40 patients in the Valproate group (control group) were randomly assigned to compare the efficacy, adverse reactions, EEG changes, Synek grading and prognosis. Results　 The effective control rate was 77.5% in the Levetiracetam group and 67.5% in the Valproate group, with no statistical difference between the two groups (P = 0.317). The onset time of Levetiracetam group was shorter than that of Valproate group, and the difference between the two groups was statistically significant (P < 0.05). Prognostic analysis: Univariate analysis showed that symptoms were not effectively controlled, successful control time ≥60 min, abnormal discharge in EEG, Synek grading and poor prognosis were significantly correlated (P < 0.05). Multivariate Logitstic regression analysis showed that, Synek grade was negatively correlated with prognosis (β= -3.867, OR < 1), and higher Synek grade was an independent risk factor and predictor of poor prognosis (P < 0.05). Conclusion　 Levetiracetam injection can control CSE more quickly and effectively, which can be used in clinic. EEG analysis (EEG abnormal discharge and Synek grading) can provide a reliable basis for judging the prognosis of CSE. [ABSTRACT FROM AUTHOR]

[Objective] To investigate the effects of multiple environmental factors on the large-scale space on the carbon (C) and nitrogen (N) nutrition and stoichiometric characteristics of the biocontrol insect Agasicles hygrophila (Agasicles hygrophila), in order to accurately assess the global The distribution law and biological control effect of natural enemy insects under environmental changes provide a scientific basis. [Method] 23 survey plots (8 terrestrial plants, 15 aquatic plants) were set up in an area where the population of the invasive weed Alternanthera philoxeroides (Alternanthera philoxeroides) continuously occurred over 100 m 2 within the range of 21°N~34°N in China, Determine the C and N content of Alternanthera philoxeroides in each plot, and simultaneously obtain the topography, climate, nutrients and other inorganic environmental indicators of the habitat of the sample plot and the C and N content of Alternanthera philoxeroides, using regression analysis and redundancy. A residual analysis (RDA) explored the influence of heterogeneous habitats on the total C, total N and C:N of the lily pads. [Results] (1) The total C (t=2.577, P=0.018) and C:N (t=2.377, P=0.027) of the lotus grass straight-chest jumper in aquatic habitats were significantly higher than those of terrestrial ones, and its total There is no significant difference between N. (2) In the terrestrial environment, both regression analysis and RDA showed that the total C and C: N of Alternanthera philoxeroides increased significantly with the average annual rainfall and the total C of Alternanthera philoxeroides, while the total N was basically not affected External environmental impact. (3) In the aquatic environment, the total C of the lotus grass jumper increases significantly with the increase of nitrate nitrogen and altitude in the water body, but there is a convex change trend between the total N and the total C of the water body, and its C:N and The average annual rainfall has a concave changing trend. [Conclusion] The lotus grass jumper has high N internal stability. The inorganic environment has a greater influence on the nutritional status of the lotus grass jumper in aquatic habitats, while the lotus grass jumper in terrestrial habitats has a higher N internal stability. Affected by climate factors and its host plant Alternanthera philoxeroides. [ABSTRACT FROM AUTHOR]

It is of great significance to analyze the net carbon effect of planting industry - as it could provide theoretical basis for lowcarbon development. By considering the dual carbon effects of planting industry, this paper defined the ratio of absorption to emission as carbon compensating rate, and constructed a list to assess the carbon effect of planting industry, which consisted of agricultural input, rice field methane, straw treatment and crop carbon sequestration. Then, this paper estimated the carbon compensating rate of planting industry in China from 2000 to 2018. Besides, the evolution and distribution of the rate were explored, and the convergence of regional differences was analyzed based on the spatial econometric model. The results were：① The carbon compensating rate of planting industry in China was averagely 0.855, whose net effect presented as a carbon source. In addition, the compensating rate was 0.761, 0.852 and 1, 117 in the eastern, central and western regions respectively, indicating that the planting industry exhibited to be carbon sources in the eastern and central regions, while it showed to be a carbon sink in the western region. In the structure of emissions, straw treatment accounted for the highest (47,751%) - and rice paddies made up for the lowest (7. 518%).② Based on the provincial distribution of carbon compensation rate in major years, the planting industry in China was transiting from a carbon source to a carbon sink. There were nine provinces showing to be carbon sinks, such as Qinghai, Xinjiang and Heilongjiang, while 18 provinces presented to be carbon sources, including Fujian, Hunan, Jiangxi, etc. Besides, the planting industry in Ningxia, Sichuan and Guangxi had transformed from carbon sources to carbon sinks. (3) The cr convergence was not found in the whole country or the three regions - while all the regions formed their own conditional p convergence clubs. The carbon effect of the planting industry was spatially related, which endowed a positive spillover effect to the convergence of neighboring provinces, showing a positive evolution characteristic of mutual promotion. Based on the conclusions above, this study suggests that policymakers should implement carbon emission mitigation from specific sources, formulate different mitigation policies by targeting regions and strengthen inter-provincial cooperation, so as to provide a theoretical basis for the coordination of the relationship between crop production and the ecological environment. [ABSTRACT FROM AUTHOR]

Precise point positioning (PPP) has been well established for retrieving the precipitable water vapor (PWV) in the static model.Yet it is not always suitable for static PPP PWV retrieving,for an instance,the GNSS antenna keeps moving.Position and zenith total delay (ZTD) are coinstantaneously estimated in dynamic PPP model,which is an option for the PWV retrieving in dynamic scenario.GNSS data over 3. 5 hours have been gathered from the Continuously Operating Reference Stations (CORS).Both static and dynamic PPPs have been applied for the CORS data processing.The result reveals that the maximum difference is 6. 6 mm,and dynamic PPP PWV graduate movement agrees in magnitude with that from static PPP PWV.A rotation arm has been designed for GNSS receiver gathering data in dynamic scenario.PPP in dynamic model can retrieve the rotation arm PWV,which makes sense to the one from CORS PWV,but lose the capacity of detecting the PWV changes.GNSS station can have dis-placement in a short term in the earthquake event.Both static PPP and dynamic PPP have been assessed for this scenario.The result reveals that displacement due to the earthquake does not make an evident effect on the PWV retrieving both in static PPP and dynamic PPP.The static PPP is still recommended for the PWV retrieving over the earthquake period. [ABSTRACT FROM AUTHOR]

BACKGROUND: Determination of ammonium nitrogen and nitrate nitrogen in soil makes great sense for indication of the nutrient status and environment evaluation of soil. The standard methods based on spectrophotometry are susceptible to interference from the color of the extraction test solution, turbidity, and other coexisting ions. Moreover, those methods are time - consuming due to the demand of decoloration. OBJECTIVES: To establish a convenient and high sensitivity method for the determination of ammonium nitrogen and nitrate nitrogen in soil, based on simultaneous extraction. METHODS: Ammonium nitrogen and nitrate nitrogen in soil were simultaneously extracted with KCl solution without decoloration, and determined by gas phase molecular absorption spectrometry. RESULTS: 50 samples were determined within Sh due to the avoidance of the color reaction process. The dynamic linear ranges of ammonium nitrogen and nitrate nitrogen were 0. 10 - 2. OOmg/L and 0. 20 - 4. OOmg/L, respectively. The detection limits were 0. 013mg/kg and 0. 002mg/kg, respectively. The recoveries ranged from 96. 3% to 100. 7%, and the relative standard deviation was below 1 % . CONCLUSIONS: Compared with the national standard method based on traditional spectrophotometry, this method has significantly improved the detection limit, precision and recovery. The method can be widely used in the field of detection of ammonium nitrogen and nitrate nitrogen in farmland soil. [ABSTRACT FROM AUTHOR]

Standard consolidation tests and consolidation creep tests were carried out on undisturbed specimens and reconstructed specimens composed mainly of Muscovite and Clinochlore by GDS advanced consolidation system. During the test, the deformation under gradually increasing load and pore water pressure at the bottom of the sample were observed. It is found that the change rule of the primary consolidation time determined by the pore pressure dissipation method and the inflection point method with the increase of the stress levels is opposite to that determined by Taylor method and Casagrande method. And the primary consolidation time determined by Taylor method and Casagrande method is far less than that determined by pore pressure dissipation method. The pore water pressure is usually not completely eliminated at the primary consolidation time determined by the Taylor and Casagrande methods. For standard consolidation test, the primary consolidation time of the undisturbed soil samples obtained by the inflection point method, Casagrande method and Taylor method is close. But the primary consolidation time of the remolded soil samples obtained by the inflection point method is greater than that obtained by the Casagrande method and Taylor method, and is also greater than that of the undisturbed soil determined by inflection point method. Furthermore, the primary consolidation time determined by inflection point method is obviously less than that determined by pore pressure dissipation method. In addition, the pore water pressure is not completely eliminated at the primary consolidation time determined by inflection point method. For consolidation creep test, the primary consolidation time of undisturbed soil and remolded soil determined by the same method is basically same, and the primary consolidation time determined by inflection point method and pore pressure dissipation method is quite close. Besides, the pore water pressure can be regarded as basically eliminated at the primary consolidation time determined by the inflection point method when the stress level is not particularly high, the consolidation behavior is roughly in accordance with the Terzaghi effective stress principle. During the standard consolidation test, the residual pore water pressure under each load increment is very small even can be ignored. Nevertheless, in consolidation creep test, with the increase of vertical consolidation pressure, the residual pore water pressure increases obviously, and the ratio of residual pore water pressure and consolidation pressure increment decreases correspondingly. [ABSTRACT FROM AUTHOR]

This paper analyzes the theoretical characteristics of traditional Chinese medicine (TCM) by applying artificial intelligence "data feeding" to it. It is believed that the essence of the theorization of TCM is to construct the database of general "clinical information'，based on the human brain as the material base and with materialist dialectics as the guiding principle to realize the digital decision-making process of "data feeding" in TCM. The conclusions are follows. Improvement in the volume and quality of the " data pool " is the most important motive force for TCM theorization. On the other hand，the decline of the data pool" will lead to the stagnation of TCM development，and the present development of TCM should focus on the clinical practice of treating diseases. In addition，further development in the field of artificial intelligence is expected to deepen our understanding of TCM by providing a new historical context. [ABSTRACT FROM AUTHOR]

【Objective】 The present paper aimed to explore the effects of heterogeneous habitats on the nutrient element content and their stoichiometric characteristics of invasive weed Alternanthera philoxeroides in Guangxi and Henan Province, providing reference for the biological invasions control and agricultural safe productions. 【Method】We collected samples in plots where A. philoxeroides continuously invaded more than 100 m2 in Laibin city, Guilin city of Guangxi Province and Xinyang city of Henan Province, measured the total carbon, nitrogen, phosphorus and potassium, as well as calculated their stoichiometric ratios. Meanwhile, we recorded the longitude, latitude, elevation, annual mean temperature and annual mean precipitation, using the methods of regression analysis and redundancy analysis(RDA) to explore the ecological effects of environmental factors. 【Result】(i) The average content of total C(380.319 mg·g-1) of A. philoxeroides in study area was relatively lower, while the contents of N(33.825 mg·g-1) and P(1.802 mg·g-1) were all higher than that of terrestrial plants in China. N:P>16 indicated the growth of this invasive plant was mainly restricted by P. Spatial variability of K content of A. philoxeroides(6.424 mg·g-1) was low.(ii) The increases in temperature and elevation significantly increased the total P and P:K but decreased N:P. The increases in longitude and latitude significantly decreased the total P and P:K but increased N:P. The trend of P:K mainly depended on the content of P. Habitat fluctuation resulted in the weakened absorptions of N, P while A. philoxeroides assimilated the C.(iii) Higher stoichiometric stability of C:K and N:K of A. philoxeroides were helpful to maintain the invasion advantage in changeable environment. 【Conclusion】The stoichiometric characteristics of A. philoxeroides were significantly influenced by heterogeneous habitats at large spatial scales, thus, we should make appropriate bio-control measures according to these characteristics of different habitats, for effectively formulating the invasion spread of this noxious weed. [ABSTRACT FROM AUTHOR]

Objective To investigate the incidence of postoperative nausea and vomiting(PONV) after acoustic neuroma surgery through retrosigmoid approach and its related risk factors, so as to provide reference for early intervention. Methods The clinincal data of 106 acoustic neuroma patients who underwent surgery under general anesthesia in the First Affiliated Hospital of Xinjiang Medical University from August 2016 to February 2019 were collected. The incidence rate of PONV in the postoperative recovery period was calculated. Multivariate logistic regression was used to analyze the risk factors of PONV after acoustic neuroma surgery. Results Of 106 patients with acoustic neuroma, 84 (79.3%) had PONV after surgery, and the average period of PONV was 2.77 days, among which 40 patients(37.7%) had mild symptoms, 27 patients(25.5%) had moderate symptoms, 17(16.0%) patients had severe symptoms, and 47(44.3%) had PONV for the first time within 12 hours after surgery. Univariate analysis showed that gender, tumor size, operation time, the status of internal acoustic meatus, postoperative pain, smoking history relative factors of PONV after acoustic neuroma surgery(P＜0.05). The results of multivariate logistic regression analysis showed that female, tumor size, drilling status of internal acoustic meatus were independent risk factors of PONV after acoustic neuroma resection via retrosigmoid approach(P＜0.05). Conclusions Female, tumor grading as T3-T4 grade, drilling the posterior wall of the internal acoustic meatus are independent risk factors of PONV of after acoustic neuroma resection via retrosigmoid approach. According to risk factors, comprehensive measures should be taken to reduce the incidence of PONV during the perioperative period. [ABSTRACT FROM AUTHOR]

One of the most important things in developing aircraft structure maintenance program is to determine the inspection task and intervals for structure accidental damage. Given the lack of using datum，the method of using rough set and case based reasoning（CBR）is introduced to civil aircraft MSG-3 analysis. According to the requirement of civil aircraft MSG-3（Maintenance steering group）analysis，the research into the method of civil aircraft MSG-3 analysis using CBR is conducted and key techniques，including the case base development，case representation，case retrieval，maintenance task and interval determination，are investigated. Meanwhile，to avoid human’s subjectivity influence，rough set is used to allocate the weight of the MSG - 3 analysis factors. Finally，we use the significant structure item of aircraft as an example to verify the method. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and safety of percutaneous nephrolithotomy with balloon dilatation and open surgery for benign ureteral stricture. Methods Computers were searched for PubMed, Cochrane Library, Embase, CNKI, Wanfang, and Wei to popularize the Chinese biomedical literature library. A randomized controlled trial(RCT)was performed to collect and screen percutaneous nephrolithotomy for balloon dilatation and conventional open surgery for benign ureteral stricture. The duration of surgery, intraoperative blood loss, postoperative hospital stay, and total were evaluated for the two surgical procedures. Differences in efficiency and other aspects. The search time is for the construction of the library until May 28, 2018. Meta-analysis was performed using RevMan 5.3 software after screening, data extraction and quality evaluation of the literature. Results Seven studies were included in the inclusion criteria. A total of 427 patients, including 207 in the balloon-expanded group and 220 in the open surgery group. The meta-analysis showed that there was no significant difference in the total effective rate between the two groups(P>0.05). There were significant differences in the operation time, intraoperative blood loss and postoperative hospital stay between the two groups(P<0.05). Conclusion Compared with traditional open surgery, sacral percutaneous nephrolithotomy with balloon dilatation can achieve higher surgical safety under the same therapeutic effect. [ABSTRACT FROM AUTHOR]

After the September 11, 2001 event, a series of regulations was issued by USA Nuclear Regulatory Commission, Nuclear Energy Institute, Department of Energy as well as National Nuclear Safety Administration of China. It is specified that the newly built nuclear power plant ( NPP) should be designed to resist the accidental impact and terrorist attack by large commercial aircraft. In the present paper, from the three aspects, e. g. , integral responses of NPP under aircraft fuselage impact, local responses of NPP under aircraft engine impact, structural vibrations of nuclear island buildings, the state of the art in the theoretical model, prototype and reduced scale modelling test, numerical simulations for the damage and failure of nuclear island infrastructures under large commercial aircraft impact were reviewed comprehensively. Furthermore, our recent work in the above areas were briefly introduced, inducing the fine finite element models of four typical aircrafts ( F4 fighter, Airbus A320, A380, MA600) , four NPP infrastructures ( prestressed RC NPP containment, RC NPP containment and auxiliary buildings, steel concrete NPP containment and auxiliary buildings，RC large-scale cooling tower)，as well as the reproductions of the whole collision processes based on numerical simulations. Besides, the reduced scale engine impact test on normal RC and ultra-high performance concrete target plates, the corresponding numerical simulations, as well as the calculation approach for the terminal ballistic parameters of engine were introduced. Finally, the shortages in the existing work such as calculation of impact force, intergral response, local damage, vibration effect and multi-hazard impact, and the future research recommendations were pointed out. [ABSTRACT FROM AUTHOR]

Sulforaphane (1 -isothiocyanate -4 -methanesulfonylbutane, SFN), also known as raphanin, is a bioactive substance extracted from broccoli plants, and is one of the strong antioxidant found so far. Once oxidative stress stimulus occurs, sulforaphane can induce the expression of various antioxidants and detoxifying enzymes by activating the Nrf2/ARE pathway to exert an antioxidant effect. The sulforaphane can also directly react with other cellular targets to exert biological effects such as inducing apoptosis and regulating inflammatory mediators. Sulforaphane has been used as an antioxidant in various disease research, such as digestive disease, respiratory diseases, cardiovascular diseases and tumors. However, there are few studies on its function in the female reproductive system. This article reviews the basic structure, biological effects and research progress of sulforaphane in female reproductive system. [ABSTRACT FROM AUTHOR]

Carriage positioning is the prerequisite process for the automatic control of the drilling of the drill rig. The original method is only feasible in the ideal working face has no stone stacked. The carriage of drill rig is tilted laterally when there are stones stacked. The push beam can be rotated laterally around the laser beam. The angular variable cannot be locked, and there is an infinite solution to the pose of the carriage, resulting in a large positioning error or even unusable. In order to solve this problem, a new method of using the booms in dual sides to participate in positioning is proposed. It is theoretically proved the feasibility, and the problem of finding the unique solution of the carriage pose is solved to solve the vertex position of the triangle when the length are fixed; the transformation relationship of the carriage-laser coordinate system is determined based on the D-H method and the coordinate system translation; the set condition is introduced to find the actual origin position of the carriage coordinate system, and the angular values of the dual sides of the drill rig are calculated by MATLAB programming. Solve the pose matrix of the carriage coordinate system in the working face coordinate system to realize the carriage positioning. The field test results show that the new method fully adapts to the height change of the stone condition, and can quickly determine the actual position and pose of the carriage; the vertical positioning error of the carriage is within 5%. Drilling positioning accuracy is within 12 cm when the error compensation method is not used. By comparing the influence of two methods on the drilling positioning effect, it is found that the original method has the phenomenon that the positioning error is transmitted to the non-positioning side boom. When measured data of total station are accurate, the average positioning error of blast-holes in the non-positioning side is 94% higher than that in the positioning side. There is no such problem with the positioning of the new method. The positioning accuracy of the blast-holes in dual sides is consistent with that in the positioning side of the original method, which is advantageous for error compensation. The new method has been successfully verified in the roadway and is universal. It can be utilized to the positioning of the same type of drill rig. [ABSTRACT FROM AUTHOR]

The Poly(ethylene glycol) diacrylate(PEGDA)/ Sodium alginate(SA) composite hydrogel was synthesized by Stereolithographic (SLA) 3D Printing and Ionic Gelation. The swelling behavior、mechanical properties and Dynamic thermomechanical analysis of composites at different mass fraction of PEGDA and SA were investigated. The swelling test results show that the decrease of PEGDA content and the increase of SA content can effectively increase the equilibrium water content and absorbing rate. The compression performance test results show that the SA network can provide a “soft chain”, which is benefit for increasing the maximum compressive strain of hydrogel. The maximum compressive strain of composite hydrogel reach to 29.5% at the 50/2.5 proportion of PEGDA/SA, which is 39% higher than the hydrogel at the 50/0 proportion. DSCM results show that the Poisson's ratio of the hydrogel is 0.35-0.5; DMA results indicate that composite hydrogel has the same material structure between -20°C -100°C,the Glass Transition Temperature doesn't change with change of SA content. [ABSTRACT FROM AUTHOR]

Since reinforcement learning is time-consuming algorithm, this paper presented an online pheromone stringency guiding heuristically accelerated Q-leaming algorithm to speed up the convergence rate. Based on the heuristically accelerated reinforcement learning, heuristic function added a pheromone stringency which could he updated online according to the rewards of the training, then combined with the value function to determine the policy. This paper proved the convergence of the algorithm. Meanwhile, simulation results show that pheromone stringency guiding heuristically accelerated Q-leaming algorithm has better performance in the rate of success, steps to reach target location and rewards obtained in the learning. 'Hie algorithm can find the optimal policy faster and avoid getting into local convergence, thus effectively speeding up the convergence rate. [ABSTRACT FROM AUTHOR]

The penstocks of CCS Hydropower Station in Ecuador are characterized by deep buried depth and high waterhead. The conventional lining design leads to much reinforcement. The permeable lining is adopted in the CCS penstock. The coupling analysis of the seepage field and the finite element structure of the concrete lining was carried out and the permeable lining reinforcement was calculated. The result shows that the lining concrete can meet the stress requirements under the condition of completion and maintenance. For operating condition, the reinforcement needed by the permeable lining is quite small. For water hammer condition, the reinforcement needed by the permeable lining is quite large compared with the operating condition. The permeable lining is suitable in practice, and it can greatly reduce the amount of reinforcement compared with the conventional lining. [ABSTRACT FROM AUTHOR]

The suction tube of THSD is affected by waves, currents, and uneven ground during construction, causing displacement in both horizontal and vertical directions. The operator cannot directly observe the underwater state of the suction tube, it is necessary to sense the suction tube posture in real -time through horizontal and vertical sensors installed on the suction tube, and manually adjust the suction tube winch to achieve safe underwater construction operations of the suction tube. The adjustment process relies entirely on manual experience, and the adjustment effect varies from person to person. Aiming at the disadvantages of manual operation, a set of safety control technology for underwater construction of suction tube has been proposed, achieving automatic and unmanned control of the underwater construction process of suction tube. The technical achievements have been applied on four 3 000 m 3 TSHDs, and the effect is significant. It can adapt to various construction conditions and achieve large-scale promotion and application. [ABSTRACT FROM AUTHOR]

住院医师规范化培训紧随当下时代的步伐,对临床年轻医生提出新的要求.临床医师不仅要具备较强的临床工作能力,同样要重视科学研究能力的培养.该文从消化内科的角度探讨多年来培养住院医师科研思维和科研能力的体会与做法,强调应重视临床和科研思维结合,培养科研兴趣和创新能力,加强科研技能的训练,以培养出高素质、创新型医学人才. [ABSTRACT FROM AUTHOR]

To solve the problems of low recognition accuracy and slow convergence speed for driving behavior in driving assistant technology, a new driving behavior recognition method was proposed based on improved LRCN model. The self driving behavior data sets were adopted as input samples and were processed by Pyramid down sampling and Gauss mixture model feature extraction preprocessing algorithm, and the standard video image sequence was obtained. The image sequence was introduced into the model based on convolutional neural network and gating unit recursive network, and the optimization was conducted to get the final result of convergence. The model was calculated on the GPU with Keras framework, and environment adaptability, preprocessing algorithm and model comparison experiments were carried out respectively. The results show that the pretreatment algorithm can guarantee the convergence of the proposed model and can improve the robustness of the model recognition in different scenes and different test objects. The average recognition accuracy in the self building data set reaches 94.3% and is 4.7% higher than that of the traditional LRCN model. The model also has faster convergent speed and stronger generalization ability. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression and clinical significance of CD68 and vascular endothelial growth factor ( VEGF) in breast cancer tissues. Methods Immunohistochemistry was used to detect the expression of CD68 and VEGF in 230 cases of breast cancer tissues and the corresponding adjacent tissues. The relationship of the expression of two proteins with the clinicopathological parameters and the recurrence of breast cancer was analyzed. Meanwhile, the correlation between the two proteins was also analyzed. Results The positive rates of CD68 and VEGF in the breast cancer tissues were significantly higher than those in the adjacent tissues ( both P <0. 01 ). The positive rate of CD68 protein in the breast cancer was closely related to the clinical stage, lymph node metastasis, and ER status of breast cancer patients ( P < 0. 05). The positive rate of VEGF protein in the breast cancer was closely related to the ER status of breast cancer patients (P <0. 05 ). The positive rates of CD68 and VEGF proteins in the recurrent patients were significantly higher than those in the non recurrent patients ( both P <0. 05 ). The expression of CD68 protein was positively correlated with the expression of VEGF (rs =0.397, P<0.01). Conclusion The expression of CD68 protein and VEGF protein increase in the breast cancer tissues, and they may be involved in the occurrence, development, and recurrence of breast cancer. [ABSTRACT FROM AUTHOR]

Based on the data collected from the plots investigation along with the implementation Levins, Hurblert and niche overlap formulas, this paper investigated the niche breadth values and niche overlap values of the main herbaceous species were measured in the type locality of Petrocodon lui and soil fertility values in the native environments. The results were as follows:(1)Pet. lui had a higher important value in their habitats. It was ranked the second in the Levins and Hurblert niche breadth index. But the Pianka niche overlap showed that when a competitive relationship occurred, Pet. lui was always at a competitive disadvantage. The above showed that it had a high degree of utilization of resources in the native environment, but the competitive ability was weak.(2)There were significant differences in the environmental resources of different spaces in the karst cave environment. This leaded to the complexity of the niche overlap value and the interspecific relationship. Hence the need for research based on the difference between the biological characteristics of the species and the needs of the environment.(3)There were certain relations between differently ecological factors and resource availability in the type locality of Pet. lui. Because of the very weak competitiveness of Pet. lui with its accompanying plant species, this mechanism provides some protection to alleviate the pressure on struggling. Therefore, we should make it a priority to protect the natural habitat in our later work. [ABSTRACT FROM AUTHOR]

ABCG2 and SLC2A9 encode the uric acid transporters ABCG2 and GLUT9. ABCG2 single nucleotide polymorphism (SNP) can reduce the expression and transport function of ABCG2 protein, and then cause intestinal uric acid excretion dysfunction, resulting in the increase of blood uric acid. The regulation of blood uric acid by SLC2A9 is complicated. Loss of function of SLC2A9 may lead to decreased renal tubule uric acid reabsorption, impaired intestinal uric acid excretion and impaired hepatic uric acid uptake. ABCG2 promotes gout attacks by causing hyperuricemia(HUA) and increasing inflammatory responses. On the contray, loss of function of SLC2A9 can instead reduce oxidation and inflammatory responses. In addition, ABCG2 has a close relationship with early-onset gout and its SNP is a risk factor for early onset gout. [ABSTRACT FROM AUTHOR]

BACKGROUND: Increasing evidences support that the physical properties, especially stiffness, can regulate the directional differentiation of stem cells. OBJECTIVE: To review the effects of extracellular matrix on stem cell behaviors, and the research progress concerning the influence of physical properties of biomaterials on stem cell differentiation. METHODS: The first author retrieved CNKI and Web of Science databases using the keywords of “extracellular matrix, bioscaffolds materials, chemical property, physical property, substrate rigidity, stem cell differentiation” in Chinese and English, respectively. Finally, a total of 31 literatures were included for analysis. RESULTS AND CONCLUSION: The physicochemical properties expose effects on the cell proliferation, migration and differentiation, and especially the regulatory effect of stiffness on the cell differentiation has a revelation for tissue engineering and regenerative medicine. Searching for more biochemical and physical factors interacting with the stiffness of extracellular matrix will enable us to control cell behaviors accurately and to prepare an ideal scaffold closely similar to in vivo environment. [ABSTRACT FROM AUTHOR]

Objective · To investigate the difference in myocardial strain of left ventricle between obstructive hypertrophy cardiomyopathy (HCM) and nonobstructive HCM. Methods · Cardiac magnetic resonance imaging (MRI) exam was performed on 48 sequential enrolled patients with HCM (18 with obstructive HCM, and 30 with nonobstructive HCM), whose left ventricular ejection fractions (LVEF) were over 50%. Twenty-five healthy volunteers were examined as normal controls. Global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS), LVEF, left ventricular end diastolic volume (LVEDV), left ventricular mass (LVM), left ventricular end diastolic volume index (LVEDVI), and left ventricular mass index (LVMI) were collected and compared. Radial strain, circumferential strain and peak radial displacement were also measured in medial segment of left ventricle according to American Heart Association (AHA) 17-segment model. Results · ① LVEF of the patients with obstructive HCM was bigger than those of nonobstructive HCM patients and control group (P<0.05). LVM and LVMI of the HCM groups were bigger than those of control group (P<0.01). ② Left ventricle GLS, GRS, and GCS significantly decreased in the patients with nonobstructive HCM compared to those with obstructive HCM (P<0.05). The three parameters of two HCM groups were significantly lower than those of healthy volunteers (P<0.05). ③ Compared with obstructive HCM patients, he segmental parameters of left ventricule, the medial segment circumferential strain and radial strain of nonobstructive HCM patients significantly decreased (P<0.05), and the two parameters of both HCM groups were lower than those in healthy volunteers. Compared with obstructive HCM patients and healthy volunteers, peak radial displacement of left ventricule medial segment in nonobstructive HCM witnessed a significant decrease, while no significant difference was observed between obstructive HCM patients and healthy volunteers. Conclusion · In the LVEF preserved HCM patients, the myocardial strain of left ventricle in nonobstructive HCM patients decrease significantly than that in obstructive HCM patients, which may result in the different clinical outcomes in two types of HCM patients. It is suggested that the myocardial strain is more sensitive than ejection fraction in the evaluation of myocardial performance of HCM patients. [ABSTRACT FROM AUTHOR]

In order to realize a rapid and accurate identification for types of macronutrient water soluble fertilizers, a rapid identification device was developed by using a characteristic frequency method on the basis of a sensor designed according to the dielectric properties of water soluble fertilizer. The device was mainly composed of a ±5V voltage regulator circuit, a single chip microcomputer control circuit, an excitation signal generation circuit, a sensor, a true RMS(root mean square) conversion circuit and an LCD (liquid crystal display) display module. With 6 kinds of common macronutrient water soluble fertilizers on the market as research objects, and selecting the mass ratio of 1:30, 1:1000, and 1:3000, the frequency response characteristics of 18 groups of macronutrient water soluble fertilizer samples were studied in a series of excitation signals, whose frequency range was from 1 to 10 MHz, which was divided into 1-100 and 100-1000 kHz and 1-10 MHz. It was found that the characteristics frequencies of excitation signals for the 6 kinds of water soluble fertilizers, i.e. nitrogen, phosphorus, potassium, nitrogen and phosphorus, nitrogen and potassium, phosphorus and potassium, were 30, 40, 50, 600, 700 and 800 kHz, and 3, 4 and 5 MHz. According to the response pattern of each kind of water soluble fertilizer at its characteristic frequency, the identification strategy of 6 kinds of macronutrient water soluble fertilizers was obtained. Whether the sensor electrode's long-term work in the fertilizer was stable or not, would directly affect the device's identification effect. In order to test the stability of sensor electrode, the samples of 3 concentrations i.e. 1:10, 1:100 and 1:1000 were prepared. Respectively, the sensor electrode was immersed in the sample and its output voltage was monitored continuously for a month. The results showed that the maximum error of the sensor electrodes in the 3 kinds of samples was 0.28%, 0.19% and 0.10% respectively for one month, which indicated that the sensor electrode would not affect the accuracy of the device in the solution measured for a long time. To meet the practical application requirements, a verification testing of identification performance for the device was carried out by preparing 234 samples of water soluble fertilizers with different types and concentrations. The test results showed that the identification accuracy of the device was 98.3%, the average time of a complete identification was 14.3 s, and the longest time of a complete identification was no more than 19.5 s. Since the difference of the sensor response signal values at each characteristic frequency in the same frequency band was relatively insufficient, in order to further reduce the influence of the measurement error caused by the response signal measurement error, the identification criterion of the redundancy judgment was adopted, that was, a complete identification process includes 3 times of judgments, take the same identification results of 2 or more than 2 times as the final identification result. It indicated that the device has good rapidity and accuracy, which could meet the requirements of practical application. The research provides a reference for realizing on-line detection of the fertilizer solution components. [ABSTRACT FROM AUTHOR]