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为解决单一食用油中营养组分缺陷问题，以大豆油、橄榄油、鱼油和亚麻籽油为基料油，测定其酸值、过氧化值、水分及挥发物含量和脂肪酸组成，然后按照中国营养学会关于脂肪酸推荐摄入量的要求，依据不同基料油的脂肪酸组成计算其配比并配制调和油，最后测定调和油的营养成分。结果表明：大豆油、橄榄油、亚麻籽油、鱼油的酸值、过氧化值、水分及挥发物含量均符合相关国家标准，4种油脂配制调和油的最适配比为45%、45%、8%、2%；调和油中主要微量营养成分及其含量为角鲨烯2.18 mg/kg、 β-胡萝卜素0.474 mg/kg、α-生育酚73.6 mg/kg、 β-生育酚0.6 mg/kg、γ-生育酚132.0 mg/kg、δ-生育酚20.4 mg/kg、总甾醇5 700 mg/kg。所得调和油符合中国营养学会关于脂肪酸推荐摄入量的要求，是一种营养平衡调和油。In order to address the problem of nutritional component deficiencies in single edible oil, soybean oil, olive oil, fish oil and flaxseed oil were used as base oils, and their acid value, peroxide value, moisture and volatile matter content, and fatty acid composition were determined. After that, according to the requirements of the Chinese Nutrition Society for recommended intake of fatty acids, the ratio of different base oils was calculated based on their fatty acid compositions, and the blend oil was prepared. Finally, the nutritional composition of the blend oil was determined. The results showed that the acid value, peroxide value, moisture and volatile matter content of soybean oil, olive oil, flaxseed oil and fish oil all met the relevant national standards, and the optimal ratio of the four oils for the preparation of blend oil was 45%, 45%, 8% and 2%. The main trace nutritional components and content in blend oil were as follows: squalene 2.18 mg/kg, β-carotene 0.474 mg/kg, α-tocopherol 73.6 mg/kg, β-tocopherol 0.6 mg/kg, γ-tocopherol 132.0 mg/kg, δ-tocopherol 20.4 mg/kg, and total sterol 5 700 mg/kg. The obtained blend oil meets the requirements of the Chinese Nutrition Society for recommended intake of fatty acids, and is a nutrient balanced blend oil.

目的在全外显子组水平对比头皮皮脂腺癌（SC）和头皮皮脂腺瘤（SA）的相关致病性基因突变的差异。方法对经过病理诊断的头皮SC和SA样本各1例，利用 Illumina HiSeq 2500平台进行全外显子组测序（WES）。筛选可疑的单核苷酸变异位点，进行突变的保守性和功能分析。利用SciClone软件来追踪亚克隆进化可以得到每例肿瘤样本的克隆性图谱信息。通过MutSigCV软件筛选得到高频显著基因，将体细胞变异与已知驱动基因进行比较，筛选出该肿瘤样本中的已知驱动基因。结果经过对比发现，与头皮SA相比，SC存在两个驱动基因ACVR1B和TFDP1的基因突变。结论头皮SC 驱动基因ACVR1B和TFDP1的基因突变如果能在更大的病例队列中得到证实，对其发生的可能机制以及治疗靶点有重要的意义。

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Objective: To study the relationship between serum lysyl oxidase like-2 protein (LOXL2) and pyruvate kinase M2 (PKM2) and long-term recurrence after radical resection in patients with cervical cancer. Methods: 302 patients with cervical cancer who underwent radical surgery in Qilu Hospital of Shandong University Dezhou Hospital from January 2017 to March 2018 were selected as observation subjects, the patients were followed up for 5 years, and 3 cases were lost to follow-up. The patients were divided into recurrence group (72 cases) and non-recurrence group (230 cases) according to whether the patients had long-term recurrence. The levels of serum LOXL2 and PKM2 were compared between recurrence group and non-recurrence group. The influencing factors of long-term recurrence after radical resection were analyzed by multivariate Logistic regression analysis, the predictive value of serum LOXL2 combined with PKM2 for long-term recurrence after radical resection were analyzed by receiver operating characteristic (ROC) curve. Results: There were 72 cases of recurrence in 302 patients 5 years after operation, and the recurrence rate was 23.84% (72/302). The serum levels of LOXL2 and PKM2 in recurrence group were higher than those in non-recurrence group (P<0.05). Multivariate Logistic regression analysis showed that, the surgical mode was laparoscopic surgery, infiltration depth≥ 1/2 muscular layer, lymph node metastasis, elevated LOXL2 and elevated PKM2 were risk factors for long-term recurrence after operation (P<0.05). ROC curve analysis showed that, serum LOXL2 combined with PKM2 had the highest predictive value for long-term recurrence in patients after radical resection, the area under curve (AUC) was 0.921, and the sensitivity was 95.24%. Conclusion: The levels of serum LOXL2 and PKM2 in patients with cervical cancer are increase, and they are risk factors for long-term recurrence after radical resection. Serum LOXL2 combine with PKM2 has a high predictive value for long-term recurrence in patients after surgery. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the effect and safety of beproprost sodium combined with acubactrosovalsartan sodium tablets. Methods: 106 patients with essential hypertension and early renal dysfunction diagnosed in our hospital from June 2022 to December 2023 were divided into control group and observation group, and 53 patients were selected in each group. Matched group: beproprost sodium, observation group: Shakubatrivalsartan sodium tablets + beproprost sodium. Compare the two groups of related indicators. Results: Compared with the matched group, the observation group had a high efficacy (P<0.05). After treatment, both groups decreased CCr, CysC, B2-MG, MAU levels, eGFR, 24 h diastolic / SBP, nocturnal diastolic / SBP, and the magnitude of change in the observed group was different compared with the control group (P<0.05). The incidence of adverse reactions in the observed group was not different from the matched group (P>0.05). Conclusion: The combination of beproprost sodium with sulbactrosovalsartan sodium tablets may improve the efficacy and safety. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)