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BACKGROUND: Anterior subtotal corpectomy, decompression and fusion is a conventional method to treat cervical degenerative diseases. A titanium cage is an important implant to maintain the stability of the cervical spine after subtotal corpectomy. In recent years, many patients have complications such as titanium cage sinking, which are highly controversial. OBJECTIVE: To investigate the internal biomechanical relationship between the tilt angle of the titanium cage and postoperative titanium cage subsidence after anterior subtotal cervical corpectomy, decompression and fusion. METHODS: A three-dimensional finite element model of the C4-C6 segment was established by CT images of a normal human cervical spine, in which the anterior subtotal resection, decompression and fusion of the C5 vertebral body were simulated, and titanium cages with different tilt angles (-6° to -1° negative angle, that is, the front edge of titanium cage is shorter than the rear edge of titanium cage; 1° to 6° positive angle, that is, the front edge of titanium cage is longer than the rear edge of titanium cage) were placed. After setting the boundary conditions, preloads of 50, 100 and 150 N were applied respectively on the C4 vertebral body. The stress value of each contact point between the titanium cage and C4 lower-end plate and C6 lower-end plate (seven stress contact points on the contact surface of titanium mesh) was recorded and statistical analysis was conducted. RESULTS AND CONCLUSION: (1) The tilt angles of the titanium cage of the positive angle group and negative angle group under 50, 100 and 150 N stress respectively were found by Mann Whitn test, with P < 0.05, which was statistically significant. The dispersion coefficients of the positive angle group were smaller than those of the negative angle group under 50, 100 and 150 N stress conditions. (2) Under 50, 100 and 150 N stress conditions, the Wilcoxon sign rank test in the positive angle group of titanium cage tilt angle found that when the angle was set to 1° to 5°, the difference was not statistically significant (P > 0.05). However, when the tilt angle of the titanium cage was set to 6°, the difference was statistically significant (P < 0.05). (3) Under 50, 100 and 150 N stress conditions, the Wilcoxon sign rank test in the negative angle group of titanium cage tilt angle found that when the tilt angle was set to -1° to-6°, the difference was not statistically significant (P > 0.05). (4) It is concluded that in the sagittal position, the titanium cage with a positive tilt angle is more stable than with a negative tilt angle, which is more suitable for clinical use. The tilt angle of the titanium cage is relatively stable in the range of 1° to 5°. When the tilt angle is 6°, the stability starts to decline, which is easy to cause complications of titanium cage sinking after surgery. It is more suitable to select the titanium cage with a tilt angle of 1° to 5° according to the clinical situation during surgery to improve the efficacy. [ABSTRACT FROM AUTHOR]

In order to explore the highly effective antibacterial active components and their compatibility of dandelion and Caulis Lonicerae japonicae, ethanol extraction and D101 macroporous resin column chromatography and antibacterial activity tracking were used to optimize their active components, and then their contents of total flavonoids, organic acids and polyphenols were analyzed and their compatibility activities were studied. The results showed that their antibacterial active components were extracted by 70% ethanol and separated by D101 macroporous resin column chromatography, and then eluted by 70% or 50% ethanol. They not only had strong broadspectrum antimicrobial activity against 9 tested pathogenic bacteria of livestock and poultry (Dandelion′s MIC and MBC values were about 1.95 mg/mL and 15.63 mg/mL, and Caulis Lonicerae japonicae′s MIC and MBC values were 1.95 mg/mL and 31.25 mg/mL), but also dandelion′ s antibacterial active components had higher contents of total flavonoids and polyphenols, and Caulis Lonicerae japonicae had higher contents of polyphenols. Compatibility studies showed that when the higher antibacterial active components of dandelion were used with a small amount of water elution parts of Caulis Lonicerae japonicae (16∶1-4∶1) or its antibacterial active components (16∶1-1∶1), there was a certain additive effect on some tested bacteria. The results indicated that the separation process of the highly effective antibacterial active components of dandelion and Caulis Lonicerae japonicae was simple and efficient, and they had strong broad-spectrum antibacterial activity, and appropriate compatibility could achieve better antibacterial effect. [ABSTRACT FROM AUTHOR]

Objective To explore the pathogenic and clinical characteristics of 7 cases of double bacterial hepatic abscess. Methods The clinical data of 7 cases of double bacterial hepatic abscess treated in this hospital from January 2015 to December 2021 were analyzed retrospectively. The bacterial spectrum, clinical manifestations and complications were analyzed, and the clinical characteristics of double mixed bacterial hepatic abscess were summarized. Results In 7 cases of double mixed bacterial hepatic abscess, the age was 22.078.0 years old, the mean age was (58.9±17.7) years old, the mean hospital stay time was (15.6±10.9) d. Six cases (85.7%) were complicated with underlying disease and previous surgical history. Fever (71.4%) and abdominal pain (57.1%) were the main symptoms. Pneumonia and pleural effusion were the main complications. The mean diameter of hepatic abscess was (6.1±3.2) cm, and all patients were cured by percutaneous puncture and drainage of hepatic abscess combined with antibiotics for anti-infection treatment. All patients had varied degree of liver function injury. The main pathogenic bacteria were Klebsiella pneumoniae and Escherichia coli. The proportions of cephalosporin and quinolone antibiotic resistance all were 57.1% (4/7), and carbopenem antibiotic resistance proportion was 28.6% (2/7). Conclusion Double mixed hepatic abscess usually occurs in the elderly patients with complicating underlying disease and previous surgical history. Klebsiella pneumoniae and Escherichia coli are main pathogenic bacteria, moreover which are easy to have drug resistance. [ABSTRACT FROM AUTHOR]

China plays an increasingly important role in the international distant water fishery, and the distant sea squid fishing is an important part of China's distant water fishery. Studying the international competitiveness of China's distant sea squid fishing is conducive to the sustainable development of China's distant sea fishery. Taking China's ocean squid fishing as an example, this paper uses the trade data between China and major countries in the world from 2000 to 2020, adopts the Herfindahl-Hirschman index and the CMS model, and analyzes the trade structure and related main influencing factors of our country's ocean squid fishing products. The results show that in recent years, the United States, Japan and South Korea are the main import and export countries of China's squid products, and China's trade in frozen squid products with the United States, Japan and South Korea is in a surplus state. According to the calculation results of the model, the trade of China's distant-water squid fishing is divided into three stages: 2000-2008, 2009-2018, and 2019-2020. On the whole, the export market of our country's ocean squid fishing products is stable and can adapt to the adjustment and changes of the product structure in the international market, but there are also problems in the unbalanced import market, strong dependence on external market demand and showing a downward trend, and insufficient product competitiveness. Therefore, this paper puts forward suggestions for improving the development of our country's distant-water squid fishing from three aspects: optimizing the market structure, establishing an information platform, and revitalizing resource endowments, so as to improve the international competitiveness of China's distant-water fishery. [ABSTRACT FROM AUTHOR]

Objective To describe children's unhealthy eating behavior, to explore the influence of individual and family factors on children's unhealthy eating behavior, and to provide suggestions for children's health education and promotion. Methods By using the method of random cluster sampling, a questionnaire survey was conducted among 2 452 fifth-grade students and their parents from 16 medium-sized primary schools in 4 administrative regions of Beijing. Results The percentage of consumption frequency of sugary beverages, sweets, and fried puffed foods 4 days per week was 13.1%, 19.3%, and 11.0%, respectively. The results of multiple linear regression showed that the stronger ability of perceptual behavior control in personal factors (B=-0.17, P<0.01), stronger subjective supervision in family factors (B=-0.15, P<0.01), less food reserve (B=-0.14, P<0.01), and better parents' dietary behavior (B=0.14, P<0.01) were associated with better eating behavior. Conclusion Children's unhealthy eating behavior is affected by many family factors. Health education for parents and control and intervention of children's unhealthy eating behavior should be strengthened. [ABSTRACT FROM AUTHOR]

In order to study the seismic damage performance of circular steel tubular steel recycled concrete composite columns, 11 composite columns were tested under low cycle repeated loading, and the effects of recycled aggregate replacement rate, axial compression ratio, diameter thickness ratio, section steel ratio and section steel form on the seismic damage performance of composite columns were also analyzed. The combined coefficient on the effects of recycled aggregate replacement rates and axial compression ratio was determined by numerical inversion method, the effects of deformation and energy were comprehensively considered, the Park-Ang damage model was revised, and the recycled concrete of circular steel tube section steel was established. The seismic damage model of the composite column and its validity are verified. Based on the experimental study, the composite column was divided into five personality levels: normal use, temporary use, use after repair, life safety, and collapse prevention. The damage indicators were quantified by combining the behavior levels, and the corresponding quantitative index, damage degree and damage index area of composite columns under different seismic performance levels are established to provide reference for seismic performance design. [ABSTRACT FROM AUTHOR]

Taking the comprehensive sample ol lead-zinc oxide ore in Lanping mining area as the research object, identify the structure ol the ore, elemental composition, mineral composition and content, the embedding characteristics ol the target mineral, the symbiotic relationship between the target mineral and other minerals, and the occurrence state of the target elements (lead and zinc) by means of chemical analysis, phase analysis, X-ray diffraction analysis and polarized microscope analysis. The results ol process mineralogy show that useful minerals are lead-zinc minerals, including Pb 1. 26% and Zn 8. 40%・ Lead in ore is mainly lound in cerusite and galena;Zinc is mainly lound in szaskaite, heterogeneous ore and sphalerite; Gangue minerals are calcite, quartz, dolmicite and pyrite(marcasite), There are many kinds ol lead and zinc minerals and the symbiotic relationship with other minerals is more complex. The disadvantages ol easy mudzing crushing will seriously affect the lead and zinc grade and recovery index. In view ol this, it is advisable to adopt segmented flotation, lead selection first and then zinc selection. The research results can provide scientilic basis for the Ilotation process transformation ol Lanping lead and zinc oxide mine and the rational development and utilization ol lead and zinc oxide resources. [ABSTRACT FROM AUTHOR]

As a new form of tailings disposal and utilization, cemented tailings discharge technology is mainly applied in arid and rainless places, and the backfill body is exposed to a high-temperature environment for a long time. Based on this characteristic, this paper carried out research on the multi-scale temperature-strength coupling characteristics of cemented tailings backfill bodies. The results show that in the early stage of the hydration reaction, high-temperature curing can promote the hydration reaction of cementitious materials, thus improving the strength of the backfill body, but it will have a negative impact on the strength of the backfill body in the later stage; high-temperature curing has different effects on the amount of hydration products in the early and late stages of backfill body, but it does not affect the type of hydration products. The increase of hydration products will make the structure of the backfill body denser and the connection between particles become more solid, which is manifested as a more compact structure in SEM images on the micro level while on the macro level an increase in strength and a decrease in porosity. [ABSTRACT FROM AUTHOR]

目的 总结复发性胸腺瘤患者信迪利单抗治疗过程中出现心肌损伤的原因, 探讨有效处理方法. 方法 对1例复发性胸腺瘤信迪利单抗治疗过程中出现心肌损伤的患者临床资料作回顾性分析. 结果 患者2年前因胸 腺瘤接受手术切除（R2切除) +术后放射治疗, 2年后出现复发伴肺转移, 4周期CAP方案（环磷酰胺890 mg + 盐酸 表柔比星130 mg + 顺铂80 mg）化疗后疾病进展. 与患者家属沟通后, 予以信迪利单抗200 mg静脉注射（每三周一 次）联合CAP化疗. 联合治疗1周期后, 出现心肌酶谱升高, 完全性右束支传导阻滞, 眼睑下垂等心肌损伤症状, 考 虑为免疫性心肌炎. 使用甲强龙500 mg冲击治疗及其他对症支持治疗后, 症状无明显好转, 加用抗心律失常药物 (胺碘酮, 艾司洛尔), 吗替麦考酚酯及免疫球蛋白, 但患者病情恶化于次日凌晨2时突发呼吸心脏骤停, 抢救无效死 亡. 结论 复发性胸腺瘤患者应用信迪利单抗治疗过程中可能发生心肌损伤, 发生原因可能与胸腺为免疫器官及 免疫治疗联合化疗的不良反应有关. 对于使用免疫治疗联合化疗的胸腺瘤患者应高度警惕, 需动态监测心肌损伤 指标, 早期识别, 分级治疗. [ABSTRACT FROM AUTHOR]

目的 探讨荧光导航显像技术在肝外胆道系统教学中的应用效果。方法 选择石河子医科大 学2021年在该院肝胆外科实习的40名临床医学专业学生作为研究对象, 将其分为观察组及对照组, 每组20 名。对照组实习医师观看普通腹腔镜下胆囊切除术 (LC) 录像, 观察组实习医师观看荧光导航 LC手术录像, 并 保证后者所观看教学录像中有肝外胆道的荧光-白光实时对比影像。经过理论及临床教学后, 比较2组学生教 学效果和教学满意度之间的差异。结果 2组实习医师在年龄、性别、入科前理论考试成绩等方面比较, 差异无 统计学意义 (P>0.05); 在胆囊三角解剖结构识别评分方面, 观察组学生平均得分为 (93.0±1.4) 分, 对照组为 (81.2±1.2) 分, 差异有统计学意义 (P<0.05)。问卷调查结果显示, 观察组学生在教学满意度、学习兴趣、帮助 理解理论知识、解剖要点记忆深度及临床思维能力等方面评分均高于对照组, 差异有统计学意义(P<0.05)。 结论 荧光导航显像技术在肝外胆道系统教学的应用, 能够明显提高教学效果, 帮助学生理解胆道疾病的相关 理论内容, 培养学生临床思维能力。 [ABSTRACT FROM AUTHOR]

Objective To investigate the regulatory effect of JAK2/STAT3 signaling pathway inhibitor AG490 on the functional phenotype of M2-like macrophages and its effects on proliferation, apoptosis, migration, and invasion of gastric cancer cells. Methods Human mononuclear cell line THP-1 was induced to differentiate into M0 macrophages by PMA in vitro. The M1-like phenotype was induced by LPS and IFN-γ, and M2-like phenotype was induced by IL-4 and IL-13, respectively, and identified by immunofluorescence labeling CD68, CD86 and CD206. The mRNA expressions of CD163, Arg1, CCL22, PPARγ, IL-10, IL-20 and TNF-α were determined by RT-qPCR. The expressions of key proteins in JAK2/STAT3 signaling pathway were detected by Western blotting. M2-like macrophages were treated with JAK2/STAT3 inhibitor(AG490)to observe the expression level of marker genes for M2 like phenotype. Macrophages were co-cultured with gastric cancer cells, and the effects of the macrophages on proliferation, migration, invasion, and apoptosis of gastric cancer cells were detected by CCK-8 method, healing assay, transwell intracellular Matrigel invasion assay, and flow cytometry. The xenograft tumor model of MKN45 gastric cancer in nude mice was prepared, and the tumor size and quality were observed for 20 days after the model was established. Results THP-1 cells were induced into M1-like macrophages and M2-like macrophages. M1-like marker(CD86)and M2-like marker(CD206)were identified by flow cytometry. The P38MAPK, JAK2, p-STAT3/STAT3 protein levels of M2-like macrophages treated with AG490 were significantly reduced. The mRNA expression levels of Arg1, CCL22, PPARγ and IL-10 were significantly reduced in the group of M2-like macrophages treated with AG490. Co-culture of M2-like macrophages with gastric cancer cells could promote gastric cancer cell viability, increase migration and invasion ability, and inhibit apoptosis. When the group of M2-like macrophages treated with AG490 was co-cultured with gastric cancer cells, the proliferation activity of MKN-45 cells and MGC823 was significantly lower than that in M2 group(1.047±0.062 vs. 1.426±0.076, 1.149±0.006 vs. 1.301±0.015). Compared to M2 group, the migration(100.0%±5.73% vs. 72%±3.85%)and invasion ability(100.0%±7.40% vs. 60%±6.54%)of MGC823 gastric cancer cells in AG490 treatment group were significantly reduced. The apoptosis rate of MGC823 cells in the AG490 treated group was significantly higher than that in M2 group(27.51%±0.70% vs. 20.82%±0.92%). In the nude mouse xenograft tumor model, the volume and weight of the transplanted tumor collected at day 20 were significantly lower in AG490 treated group than in M2 group(736.04±182.34 vs. 1 080.5±250.57)mm³, (0.64±0.11 vs. 0.87±0.17)g. Conclusion AG490 downregulates the activation level of JAK2/STAT3 signaling pathway in M2-like macrophages, inhibits M2-type polarization, partially reverses the cancer-promoting function of M2-like macrophages, inhibits proliferation, migration and invasion of gastric cancer cells, and induces apoptosis. The JAK2/STAT3 signaling pathway can be further studied as a potential therapeutic target for gastric cancer. [ABSTRACT FROM AUTHOR]

Objective: To analyze the application value of serum inflammatory cytokines combined with T lymphocyte subsets in acute respiratory distress syndrome. Methods: 70 ARDS patients admitted to our hospital from July 2021 to December 2022 were selected as research subjects and divided into mild, moderate and severe groups. Serum inflammatory factors and T lymphocyte subsets of all selected patients were detected, and the relationship between serum inflammatory factors and T lymphocyte subsets and oxygenation index (OI) and Number of B line of lung ultrasonography in patients with acute respiratory distress syndrome was analyzed. The prognosis of patients with acute respiratory distress syndrome after 28 days was observed and divided into death group and survival group. The predictive efficacy of serum inflammatory factors combined with T lymphocyte subsets on death of patients with acute respiratory distress syndrome was analyzed by ROC. Results: The expression levels of interleukin-6 (IL-6), interferonγ (IFNγ) and Th17 cells in peripheral blood in the observation group were higher than those in the control group, and the Th17/Treg ratio was higher than that in the control group (P<0.05). There was no significant difference in the proportion of Treg cells in peripheral blood between the two groups (P>0.05). There were significant differences in serum IL-6, IFNγ expression levels, Th17 cell proportion in peripheral blood and Th17/Treg ratio in mild, moderate and severe groups,and pairwise comparison showed significant differences (P<0.05). According to Pearson correlation analysis, the serum IL-6 and IFNγ expression levels, Th17 cell ratio and Th17/Treg ratio in peripheral blood of patients with acute respiratory distress syndrome were negatively correlated with OI (P<0.05), but positively correlated with Number of B line (P<0.05). The expression levels of IL-6, IFNγ in serum and Th17 cells in peripheral blood in death group were higher than those in survival group, and the Th17/Treg ratio was higher than that in survival group (P<0.05). According to ROC curve analysis, the AUC of IL-6, IFNγ combined with Th17/Treg ratio to predict death in patients with ARDS was 0.935.Conclusion: Serum inflammatory cytokines and T lymphocyte subsets are related to the severity of acute respiratory distress syndrome, and IL-6, IFNγ combined with Th17/Treg ratio can predict poor prognosis,which is worthy of clinical attention. [ABSTRACT FROM AUTHOR]

The L-shaped cantilever beam structure has many unique advantages such as large flexibility, strong designability, full utilization of space and various deformation modes during vibration, and is widely regarded and studied. A differential quadrature method was proposed to solve the natural frequencies and modes of rectangular-section homogeneous slender L-shaped cantilever beams with additional end masses. In the double coordinate systems, the dynamic equations for the L-shaped cantilever beam based on the Euler-Bernoulli beam theory were established. With selected roots of the Chebyshev polynomial as the node coordinates, the Lagrange interpolation basis function was employed, the weight coefficients of each order were solved, and the boundary conditions were considered, to obtain the natural frequencies and modes of all orders of the structure through resolution of the generalized matrix eigenvalue problem. The theoretical solution of the natural frequencies was verified in comparison with the previous theoretical results and the finite element results. Finally, the effects of the end mass, the length ratio, the width and the thickness of the inner and outer beams on the natural vibration characteristics of all orders were discussed. This method can be further applied to the study of related structural vibrations. [ABSTRACT FROM AUTHOR]

Stroke is one of the leading causes of death and disability worldwide, but its mechanism remains unclear. Forkhead box protein O3a （FoxO3a） is an important transcription factor protein involved in a variety of cellular processes. Recent studies have shown that the transcriptional modification of FoxO3a regulates oxidative stress, autophagy, apoptosis, inflammatory reaction and energy metabolism of cells and is involved in the initiation and progression of stroke. Clarifying the signal transduction and action mechanism of FoxO3a in stroke can bring further enlightenment for the identification of targeted drugs. In this paper, we will review the research progress of FoxO3a in the effects and targeted intervention on ischemic stroke. [ABSTRACT FROM AUTHOR]

Accurate and rapid counting has been one of the most important steps on sea foods in modern aquaculture. Taking the sea foods in a real bottom-sowing aquaculture environment as the research object, this study aims to guarantee the costsaving, highly efficient and easy counting on the multi-category sea foods using video multi-target tracking. The underwater videos of sea foods were taken as the data source. Firstly, the YOLOv7 algorithm with excellent performance was used to realize the target detector of sea treasure, providing the input for the multi-target tracking. Specifically, the image data was captured under real underwater using the "2017 Underwater Robot Picking Contest, URPC2017", and then used to train the YOLOv7 model. 17,655 images contained the holothurians, echinus, and scallops. The images were randomly divided into the training set of 14055 images in the ratio of 8:1:1, the verification set of 1800 images, and the test set of 1800 images. The training setting of the YOLOv7 detector was set as the image adaptive size of 640*640, the initial learning rate of 0.01, the momentum of 0.9, the weight decay of 0.0005, the batch size of 16, the number of training rounds of 300. One test was performed every 10 rounds of training round. The operating system was selected the Ubuntu18.04 for Haizhenpin detector training, the deep learning framework was PyTorch, the experimental processor was AMD Ryzen Threadripper 1920X 12 cores, and the graphics card was NVIDIA GeForce RTX2080. Secondly, the characteristics of high similarity were combined with the unclear appearance of the same type of sea foods in the real breeding environment. The multi-target tracking of the BYTE algorithm was used for the reference. A multi-category trajectory generation and a counting strategy were then designed for the sea treasure tracking using the trajectory ID number. Finally, an optimal combination of the indicators was also evaluated on the performance of the improved model. The test results show that the average counting precision, mean absolute error (MAE), root mean square error (RMSE), and frame rate were 91.62%, 5.75, 6.38, and 32 frames/s, respectively. All indicators were better than those of the current YOLOv5+DeepSORT, YOLOv7+DeepSORT, YOLOv5+BYTE, and YOLOv7+BYTE. Especially, the average counting accuracy and frame rate index ratio of YOLOv5+DeepSORT were improved by 29.51, and 28 percentage points than before. The MAE and RMSE of the improved model were reduced by 19.50 and 12.08, respectively. The quantity of underwater sea foods was effectively measured in the modern fishery. The finding can provide the technical reference for the production measurement and the scientific decision-making on the intelligent management of aquaculture. In addition, the underwater dataset was used to train the detection model under the same environment, in order to reduce the false detections caused by different conditions. Nevertheless, the underwater environment changes greatly, due to various influencing factors, such as lighting. Statistical counting was then performed to collect the video of marine treasures under the same environment every time during training. Therefore, the current model can be expected to improve on the different underwater environments in the future. [ABSTRACT FROM AUTHOR]

Objective To study the changes in the intestinal flora of patients with severe pneumonia (SP) and to analyze their correlation with the body's immune function. Methods Sixteen cases of severe pneumonia were selected as the observation group, and 10 cases with healthy physical examination were selected as the control group. The fresh feces of the two groups were collected, and the intestinal microbiota abundance (Ace index, Chao index) and diversity (Simpson index, Shannon index) in the feces were analyzed by 16S rDNA gene sequencing technology, and the intestinal micro‐ biota abundances of the two groups at the phylum level and genus level were compared. The immunoglobulins (IgA, IgG, IgM), lymphocyte subsets (CD3+, CD4+, CD8+ T lymphocyte count and CD4+ /CD8+ ), white blood cell count (WBC), and neutrophil count (NEUT) were compared between the two groups. Results The Ace index, Chao index, Shannon index, CD3+, CD4+, CD8+ T lymphocyte counts, IgA and IgG were lower in the observation group than in the control group, and the Simpson index, WBC, NEUT and IgM were higher (all P<0. 05). The relative abundances of Firmicutes, Proteobacteria, Bifidobacterium, Escherichia coli, Ruminococcus species, Trichobacterium and Clostridium in the observation group were lower than those in the control group, and the relative abundances of Bacteroides, Actinomycetes, Enterococcus, Streptococcus and Klebsiella were higher than those in the control group (all P<0. 05). The relative abundance of Klebsiella in the intestinal flora of the observation group was positively correlated with CD3+ and CD8+ T lymphocyte counts, the relative abundances of Ruminococcus and Trichospirillum species were positively correlated with CD8+ T lymphocyte count, the relative abundance of Clostridium was positively correlated with IgM level, the relative abundance of Streptococcus was negatively correlated with IgM level, Escherichia coli and Klebsiella were negatively correlated with IgG levels, and Enterococcus species were negatively correlated with WBC (all P<0. 05). Conclusions The abundance and diversity of intestinal flora in patients with SP decrease significantly. The abundance of beneficial bacteria decreases and the abundance of conditional pathogenic bacteria increases. The changes in intestinal flora may indirectly participate in the development and progression of SP by affecting immune function. [ABSTRACT FROM AUTHOR]

The experiment was to investigate the effect of different dietary energy levels on protein translation initiation factor gene expression in muscle tissue of Wujin pigs. Fifty-four healthy Wujin pigs with an average body weight of 15 kg were randomly divided into three groups with three replicates in each group and six pigs in each replicate. Pigs in each group were fed diets with different energy levels (11.84, 12.97 and 14.18 MJ/kg), and the experiment was divided into three stages: 15~30, 31~60 and 61~100 kg. The refueling transition period of each stage was 7 d, and the animals were slaughtered in batches at 30, 60, 100 kg, respectively. The results showed that high energy level diet could reduce lean meat percentage and muscle crude protein content, increase intramuscular fat content of pigs, decrease protein translation initiation factor gene expression. At slaughter body weight of 30 kg, the expression levels of eIF-2B and eIF-4E in low energy group were significantly higher than those in high energy group (P<0.05), and the expression level of eIF-4B gene was significantly higher than that in medium energy group (P<0.05). When slaughter weight was 60 kg, the expression levels of eIF-2B, eIF-4B and eIF-4E in high and medium energy groups were significantly lower than those in low energy group (P<0.05). At slaughter weight of 100 kg, the relative expression level of eIF-4A in high energy group was significantly lower than that in low energy group and medium energy group (P<0.05), and the relative expression level of eIF-4E in low energy group was significantly higher than that in medium energy group and high energy group (P<0.05). The relative expression level of eIF-4E in medium energy group was significantly higher than that in high energy group (P<0.05). The study indicates that protein deposition in longissimus dorsi muscle of Wujin pigs increases with the decrease of dietary energy level, while intramuscular fat content is opposite. Different dietary energy levels can significantly affect protein synthesis in muscle tissue of Wujin pigs through regulating the expression of protein synthesis translation initiation factor genes. [ABSTRACT FROM AUTHOR]

BACKGROUND: Percutaneous endoscopic interbody foraminal interbody fusion is an advanced minimally invasive method for the treatment of lumbar degenerative diseases. The traditional interbody fusion cage is not fully suitable for minimally invasive surgery. The choice of fusion cage for endoscopic lumbar fusion is still controversial. OBJECTIVE: To explore the clinical effect of percutaneous spinal endoscopic implantation of height adjustable titanium fusion cage for interbody fusion in the treatment of lumbar degenerative diseases. METHODS: A retrospective study investigated 55 patients who underwent percutaneous endoscopic lumbar fusion in the Department of Orthopedics of First Affiliated Hospital of Guangxi University of Chinese Medicine from December 2018 to June 2019. According to the different types of fusion cages implanted, they were divided into two groups. The stretch group (n=23) was implanted with a retractable height adjustable titanium fusion cage, and the general group (n=32) was used with an ordinary lumbar fusion cage. Postoperative complications were recorded in the two groups. The JOA score, Visual Analogue Scale score, and Oswestry Disability Index in the two groups were compared before and after treatment. This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi University of Chinese Medicine. RESULTS AND CONCLUSION: (1) All 55 patients were followed-up for more than 12 months. All patients obtained bony fusion without complications, such as internal fixation loosening, fracture, fusion cage displacement, or settlement. (2) Compared with those before treatment, Visual Analogue Scale scores of low back pain and leg pain, JOA score, and Oswestry Disability Index were significantly improved in the two groups at 2 weeks, 3, 6, and 12 months after operation (P < 0.05). JOA score at 12 months and Oswestry Disability Index at 6 and 12 months were significantly better in the stretch group than those in the general group (P < 0.05). (3) Compared with those before treatment, the height of the intervertebral space, the height of the intervertebral foramen of the fusion segment, the lordosis angle of the operative segment, and the lumbar lordosis angle of the two groups were significantly improved after treatment (P < 0.05). The height of the intervertebral space, the height of the intervertebral foramen of the fusion segment, the lordosis angle of the operative segment, and the lumbar lordosis angle were better in the stretch group than those of the general group at 5 days and 12 months after treatment (P < 0.05). (4) It is concluded that percutaneous endoscopic lumbar fusion is a reliable minimally invasive method for the treatment of lumbar degenerative diseases. Its combination with highly adjustable titanium fusion cage can improve its clinical efficacy. [ABSTRACT FROM AUTHOR]

Objective To investigate the short-term mortality of transcatheter arterial chemoembolization(TACE) in patients with primary liver cancer, and explore the possible causes of death and countermeasures. Methods All patients who underwent TACE at the Department of Interventional Radiology, First Affiliated Hospital of Soochow University from January 2015 to December 2020 were studied, but those with metastatic liver cancer or receiving combined treatment were excluded. The clinical and imaging data of all patients were collected before and 30 days after TACE, and the clinical characteristics of the patients with short-term postoperative death were analyzed. Death within 30 days after TACE was defined as short-term death. Results A total of 1466 TACE in 741 patients with primary liver cancer were included. Ten patients(10/741, 1.35%) died within 30 days after TACE, with a mortality rate of 0.68% for all TACE. The mortality rate of d-TACE and c-TACE was 1.62%(3/185) and 0.55 %(7/1281), respectively. The mortality rates of patients at China Liver Cancer Staging Ⅰ, Ⅱ, and Ⅲ stages were 0.45%(2/448), 0.33%(2/599), and 1.43%(6/419), respectively. The mean diameter of the largest lesion in death cases was 10.1±0.8 cm. The possible causes of death were liver failure(4 cases), rupture bleeding(3 cases), myelotoxicity(1 case), pulmonary embolism(1 case), and heart failure(1 case). Conclusion The mortality rate after TACE in patients with primary liver cancer is low, with occasional short-term postoperative deaths. The death cases are characterized by a large tumor volume, and the most common causes of short-term death are liver failure and rupture bleeding. [ABSTRACT FROM AUTHOR]

Zn-Bi-Mn-Cr-Si (ZBMCS) varistors were prepared by traditional solid thermal sintering method. The effect of sintering temperature on phase composition, microstructure and electrical properties of ZBMCS varistors were studied. With the continuous increase of sintering temperature, the average grain size of the sample increases gradually, and the pressure-sensitive field strength decreases gradually. The energy dispersion spectrum (EDS) analysis of samples shows that the increase of sintering temperature significantly reduces the content of Bi, and Mn, Cr and Si participate in the formation of Zn2 Si()i and other second phases. When the sintering temperature is 99() °C, the comprehensive properties of the samples reach the best. The maximum nonlinear coefficient is 43.36 and the minimum leakage current density is 1.89/.tA/cmJ. The breakdown field strength is 435.10 V/mm, and the maximum loss tangent tan§ under the action of 10'-1 ()b Hz external electric field is only ().()7. [ABSTRACT FROM AUTHOR]

Air cargo is an important strategic resource of country and plays an indispensable role in domestic and international trade. Scientific forecasting of air cargo demand is an important basis for airlines to make infrastructure planning and overall investment decisions. Aiming at the uncertainty of air cargo volume data, this paper introduced Bootstrap method for uncertainty estimation and proposed an interval prediction method based on decomposition integration from the practical needs. Specifically, this paper decomposed the historical data by Seasonal and Trend Decomposition using Loess (STL) method firstly, then forecasted the trend and seasonal components by Support Vector Regression (SVR) and Seasonal Autoregressive Integrated Moving Average (SARIMA), respectively. Thirdly, this paper extracted and resampled the white noise component by Bootstrap method. Finally, the prediction results were integrated and reconstructed with the processed white noise to quantify uncertainty using quantile construction intervals. The experimental results of cargo data from two hub airports in China show that the constructed interval can effectively quantify the uncertainty in combination with the predicted results, which provides a novel research idea for probabilistic interval prediction. [ABSTRACT FROM AUTHOR]

Objective To explore the pathogenic mechanism and management of moyamoya disease (MMD) concurrent with intracranial dural arteriovenous fistula (DAVF). Method The clinical data of 1 patient with MMD accompanied by intracranial DAVF was analyzed retrospectively. Results The patient was a young woman with ventricular hemorrhage as the primary symptom. DSA diagnosed MMD complicated with left transverse sigmoid DAVF. Six months after the right extracranial and extracranial vascular anastomosis, the reexamination showed that the bridging vessels were unobstructed and the fistula disappeared. Combined with literature review, MMD complicated with DAVF could be divided into two types: concurrent or secondary. The clinical manifestations were mostly cerebral ischemia or cerebral hemorrhage related to MMD. Intracranial and extracranial vascular anastomosis was often used, while most DAVFs were treated conservatively. Conclusions MMD with DAVF is rare and the etiology is unknown, which may be related to the increase of angiogenic factors. The treatment strategy depends on the clinical manifestation and classification of DAVFs. [ABSTRACT FROM AUTHOR]

Aiming at the problem that the randomness and uncertainty of the load of Battery Swap Station(BSS)of electric vehicles lead to the increase of the peak-valley difference of the load in the micro grid .a two-layer optimal scheduling method based on real-time electricity price was proposed for the coordination between BSS and the microgrid. The uncertainty model of electrical changing demand is established in BSS. Based on the time-of-use electricity price of the main network and the conventional load of the microgrid, a method for determining the real-time electricity price in the microgrid is proposed, and a coordinated double-layer optimal scheduling model of BSS and microgrid is established. The Cplex solver was called by Yalmip to solve the upper and lower models, respectively, to obtain the optimal output of the controllable micro-source inside the microgrid and the optimal charge-discharge plan of BSS. Finally, an example is given for a microgrid. and the results show that the proposed optimization method can improve the benefits of both parties and realizes the peak-shaving and valley-filling of the total load in the network. [ABSTRACT FROM AUTHOR]

In order to explore the practicability of the Unburned ceramsites derived from water treatment residuals ( UCWTR ) for remediating multiple heavy metals-contaminated wastewater, a series of static adsorption experiments were carried out here to analyze the competitive adsorption performance of Pb and Cd on the surface of UCWTR and the main factor affecting its adsorption behavior for heavy metals. Results showed that the regular co-lumnar structured UCWTR particles of abundant cracks possessed large specific surface area and rich adsorption sites, which were conducive to improve the adsorption capacity for heavy metals. Meanwhile, the functional groups within UCWTR, such as-OH, Al-OH, Fe-O and C-S-H, also were beneficial to adsorbing Pb and Cd. During the competitive adsorption process of Pb and Cd, the maximum adsorption capacities of UCWTR for Pb and Cd were 0.36 mmol • g-1 and 0.25 mmol • g-1, respectively, and the adsorption kinetics were fitted better with the pseudo-second-order model (R²cd =0.963,R²pb=0.987). The presence of Cd significantly promoted the adsorption of Pb on UCWTR, and more Cd boosted the promotive effect increasingly in a certain range of concentration of Cd. On the contrary, the high concentration Pb obviously inhibited the adsorption of Cd. Competitive adsorption isotherms of Pb and Cd were fitted better by Langmuir and Freundlich models, respectively. The higher pH value led to higher adsorption capacity of UCWTR for Pb and Cd, while the increased adsorbent dosage decreased that. The dominative existence speciation of adsorbed Pb and Cd was acid-extracted state. Compared with single adsorption by UCWTR, the competitive adsorption declined the proportion of the acid-extracted state, increased reduced and residue states, and enhanced the stability of Pb and Cd. [ABSTRACT FROM AUTHOR]

Objective To analyze the influencing factors in detection of sperm mitochondrial membrane potential（MMP） by flow cytometry. Methods After reproducibility analysis of sperm MMP using flow cytometry, semen samples that met the requirements of MMP detection were randomly collected, The effects of sample standing time, temperature, sample preservation solution, freezing and other factors on the results of MMP were analyzed. Results The semen samples with high,medium and low MMP levels were repeatedly tested by flow cytometry for 10 times, and the CV of the results was all less than 7%. With the extension of the sample storage time at room temperature, the level of sperm MMP was gradually decreased.Compared with the result of the placed sample for 30 min（43.31±13.96）, the level of sperm MMP was significantly decreased in the placed sample for 2 hours（35.44±17.23）. The decrease of MMP of semen samples stored at 2-8 ℃ was less than that of samples stored at room temperature, but there was no significant difference（P>0.05）. The level of sperm MMP in the samples with self-made sample protective solution store at 2-8 ℃ was significantly higher than that of the samples without protective agent（P<0.05）, and the decline rate of MMP level was significantly slower（P<0.05）. The temperature of semen stored at 2-8 ℃was less than that of samples stored at room temperature, but there was no statistical difference. Semen samples with cryoprotectant at 1:1 were frozen at-20 ℃, which caused a significant damage of sperm MMP（P<0.01）. Conclusion For sperm MMP detection using FCM, the sample standing time has a great influence on the test result. It is recommended to finish the test within half an hour after semen liquefaction. In order to improve the quality control and working efficiency of the laboratory, the samples is suggested to be refrigerated in the sample preservation solution and the testing can be completed within 2 hours. Frozen semen samples can not be used as internal quality control for sperm MMP detection. [ABSTRACT FROM AUTHOR]

In order to improve the utilization rate of materials, a rebar cutting optimum model used integer programming and gradient boosting decision tree was established considering the influence of processing equipment on one-dimensional rebar products. On that basis, a product sorting optimum model used greedy algorithm was established combined with the intelligent sorting device independently developed by research group, it could promote rebar cutting optimum application in production and improve production efficiency. A case study shows that the presented cutting optimum method has more advantages than the traditional optimal methods in convergence performance, searching effectiveness and solution stability, and the utilization rate of materials has been effectively improved. The sorting optimization reduces the work intensity of field personnel, and greatly improve sorting efficiency. The presented method can guarantee the cost, quality, and efficiency of process, and provides a new way for one-dimensional rebar production in construction. [ABSTRACT FROM AUTHOR]

Coin mixing mechanism is one of the privacy protection technologies of the blockchain, which faces some issues such as low efficiency, insufficient security and DoS attacks. Therefore, this paper proposed a blockchain coin mixing mechanism based on intermediator, called IMShuffle. Firstly, it divided the participants in the coin mixing transaction into different groups at random. Each group member took the initiative to broadcast and sent its own output address to its intermediator, these intermediators sent the received output address to the last node of the group. Then it used the idea of multi-layer encryption to complete the transfer of the output address of the last node between the groups. The last node of the last group received the output addresses of all participants to complete the coin mixing transaction. Experimental analysis shows that the IMShuffle has a mixing time of only 11 s when the participants reach 70. Compared with the running time of the CoinShuffle and TTShuffle mixing mechanism, it greatly improves the efficiency of the mixing transaction and shortens the time of mixing transaction. It protects the privacy of participants in the transaction process and reduces the risk of DoS attacks. [ABSTRACT FROM AUTHOR]

目的 了解山东省农村地区慢性病患者首诊机构选择现状, 探讨家庭医生签约服务对慢性病患者基层首诊 的影响。方法 采用多阶段分层随机抽样法, 于2018 年在山东省抽取3 个地级市作为研究地区, 对农村地区的居 民进行问卷调查。共纳入420 名过去2 周有就诊经历的慢性病患者。以安德森卫生服务利用行为模型为框架, 对 慢性病患者选择首诊机构的影响因素进行分析。结果 在420 名过去2 周有就诊经历的慢性病患者中, 选择基层 医疗卫生机构首诊的占78.57%, 选择医院首诊的占21.43%。logistic 回归分析显示, 签约家庭医生服务（比值比 为1.894, 95% 置信区间为1.035~3.465）、到常去的县医院时间为30~ ＜ 60 min（比值比为2.099, 95% 置信区间为 1.022~4.309）、自评健康状况好（比值比为2.538, 95% 置信区间为1.254~5.140）、患有除高血压/糖尿病外的其他 慢性病（比值比为2.226, 95% 置信区间为1.293~3.831）的患者更倾向于选择基层医疗卫生机构首诊。结论 山东 省农村慢性病患者基层首诊的比例较高, 家庭医生签约服务对促进农村慢性病患者选择基层医疗卫生机构首诊 有积极作用. [ABSTRACT FROM AUTHOR]

目的 了解山东省农村慢性病患者的家庭医生服务签约现状及其影响因素, 为进一步推进农村地区慢性病 患者签约家庭医生服务提供参考。方法 采用多阶段分层随机抽样方法对山东省农村地区居民进行问卷调查, 选 取慢性病患者为样本, 调查其一般情况和签约情况。采用t 检验、χ2 检验、logistic 回归等方法探索农村地区慢性病 患者家庭医生服务签约的影响因素。结果 1 210 例慢性病患者的家庭医生服务签约率为29.34%。不同性别、多重 慢性病患病情况、欧洲五维健康量表健康指数、饮酒情况、过去2 周体育活动参与情况、家庭年收入和文化程度 的患者, 其家庭医生服务签约率差异分别有统计学意义。年龄、多重慢性病患病情况、家庭年收入、文化程度、饮 酒情况和过去2 周体育活动参与情况可能是影响居民签约家庭医生服务的因素。结论 山东省农村地区慢性病患 者家庭医生服务签约率不高。今后应开展形式多样的家庭医生服务政策宣传, 提高慢性病患者的签约积极性;应 重点关注社会经济地位较低、健康状况较差的高龄慢性病患者, 创新开展有针对性的、个性化的签约服务, 让家 庭医生政策惠及全民. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The up-to-now researches on the effect of transcranial direct current stimulation (tDCS) on exercise performance are in the initial phase, and the existing conclusions are inconsistent. This meta-analysis attempted to quantitatively evaluate the effect of tDCS on muscle strength and endurance performance of healthy adults, providing new evidence for new neuroelectrophysiological techniques as well as improving the muscle function. METHODS: To collect randomized controlled trial (RCT) studies regarding the effects of tDCS on muscle strength and endurance performance in healthy adults, the following databases were searched from inception to October 2019: Web of Science, PubMed, Sport Discus, and CNKI. According to the Cochrane Systematic Review Manual, Review Manager 5.3 software was used to evaluate the methodological quality of the literature included and to analyze the combined effect amount. RESULTS: A total of 15 RCTs involving 201 healthy subjects were included. The meta-analysis indicated that compared with the experimental group, tDCS intervention had insufficient evidence in improving muscle strength: I²=47%, 95% confidence interval [-0.79, 0.23], P=0.27 > 0.05, standard mean difference=-0.28. Compared with the control group, the function of tDCS stimulation to improve the performance of endurance was more evident, and the combined effect amount tended to a medium effect: I²=57%, 95% confidence interval [0.10, 0.76], P=0.01 < 0.05, and standard mean difference=0.43. CONCLUSION: tDCS intervention has no statistical significance in improving strength, but it is effective in improving endurance performance in general. More rigorous and extensive experimental researches are warranted to explore the tDCS neurophysiological mechanism. [ABSTRACT FROM AUTHOR]

Objective To evaluate the clinical efficacy of adult kidney transplantation from unilateral pediatric donor kidney. Methods Clinical data of pediatric donors (n=10) and adult recipients (n=19) undergoing kidney transplantation were retrospectively analyzed. The changes of renal function, liver function and the maximal diameters of the kidney allografts were compared at 1, 7, 14, 28, 60 d after operation. The short-term survival and incidence of postoperative complications of the recipients were analyzed. Results Ten donors included 6 males and 4 females, aged (7±3) years old, with a body mass index (BMI) of (16.3±3.8) kg/m2 . All donors were donation after brain death followed by cardiac death. Among 19 recipients, 12 were males and 7 were females, aged (34±12) years old, with a BMI of (20.3±1.3) kg/m2 . An oblique incision was created in the lower right abdomen of the recipients. The arteries and veins of donor kidney were anastomosed with the external iliac arteries and veins of the recipients. The ureter of donor kidney was anastomosed with the bladder of the recipients. After anastomosis, the kidney was placed and fixed in the right iliac fossa. The serum creatinine and blood urea nitrogen levels of the recipients were decreased at 1 week after kidney transplantation, and restored to normal range at postoperative 2 weeks. All parameters related to liver function were normal after operation. At postoperative 1 month, the maximal diameters of the kidney allografts were (9.5±0.3) cm on average, which basically reached those of normal adults. The 1-year survival rate of 19 recipients was 95%. One recipient died from pulmonary infection after ineffective treatment. Two recipients developed rejection, and 1 recipient experienced urinary system infection, who were healed after corresponding treatment. Conclusions Adult kidney transplantation from unilateral pediatric donor kidney is safe, feasible and effective, which can be utilized to enlarge the source of donor kidneys. [ABSTRACT FROM AUTHOR]

Polyaniline (PANI) structure will collapse after continuous charging and discharging, leading to the problem of poor cyclic stability. In this paper, aniline is polymerized in situ on the surface of biomass carbon (MnOC) material by in situ polymerization technology, and PANI particles are controlled to grow orderly on the surface of MnOC. The prepared PANI/MnOC composite electrode material has the characteristics of both double-layer capacitance and Faraday pseudocapacitance. The analysis and test results show that the PANI/ MnOC composite electrode material consists of a porous network of micropores, mesoporous and macropores, which is conducive to charge storage and transmission. Ry measu ring its electrochemical performance, it is found that compared with pure PANI, the specific capacitance of PANI/MnOC composite elect rode material is 385.0 F/g when the current density is 1.0 A/g, which is higher than the specific capacitance of pure PANI. When the current density is 2.0 A/g and the current density is 5000 cycles continuously, the capacitance retention rate of composite electrode material reaches 82.2%. [ABSTRACT FROM AUTHOR]

Objective: To explore and study the characteristics of microendoscopic discectomy (MED) in the treatment of lumbar disc herniation and the prone complications. Methods: A total of 72 patients with intervertebral disc herniation, who were diagnosed and treated in Xijing 986 Hospital, Fourth Military Medical University from January 2017 to February 2020, were selected and were randomly divided into MED group(n=36) and control group(n=36). The MED group was given MED surgery treatment; the control group was given open surgery. The postoperative complications were recorded in the two groups. Results: The excellent and good rate (97.2 %) of 6 months after operation in the MED group was significantly higher than that (77.8 %) in the control group (P<0.05). The Japanese orthopaedic association (JOA) scores 1 month and 6 months after surgery of the two groups were higher than before operation, and the MED group was higher than the control group (P<0.05). The visual analogue scale (VAS) scores 1 month and 6 months after surgery of the two groups were lower than before operation, and the MED group was lower than the control group (P<0.05). The incidence (5.6 %) of complications such as residual nucleus pulposus tissue, nerve root injury, dural rupture, and cerebrospinal fluid leakage in the MED group 6 months after surgery was significantly lower than that(33.3 %) of the control group(P<0.05). Conclusions: In the treatment of patients with lumbar disc herniation, MED can improve the patients' lumbar spine function, promote pain relief, increase the overall excellent rate of treatment, and reduce postoperative complications. [ABSTRACT FROM AUTHOR]

BACKGROUND: Taking into account the stability of spinal fixation, the preferred approach for lateral lumbar interbody fusion is commonly the utilization of posterior bilateral pedicle screws, typically performed in two stages. An alternative method involving the posterior approach of unilateral fixation using lateral vertebral nail rods in the lateral decubitus position has shown potential for enhanced mechanical stability. This technique also offers additional advantages such as reduced operation time, lowered risks, and decreased costs, making it a promising area for further investigation. OBJECTIVE: To compare the biomechanical effect of lateral lumbar interbody fusion with four different types of posterior instruments. METHODS: A validated L3-5 finite element model was modified to simulate four different types of lateral lumbar interbody fusion: Model A: posterior bilateral pedicle screw fixation; Model B: posterior unilateral pedicle screw fixation; Model C: lateral bilateral screw fixation; Model D: lateral unilateral screw fixation. The stability in the range of physiological motion, and the stress difference of screw fixation and interbody fusion apparatus were compared among the models. RESULTS AND CONCLUSION: (1) When compared with the intact model, all reconstructive models displayed decreased motion range at L4-5. Model A had a more obvious range of motion decline. (2) In the flexion, lateral flexion and axial rotation, the differences between the peak stress of the lateral screw fixation and the peak stress of the posterior screw fixation were more than 67.74 MPa, 80.10 MPa and 43.95 MPa, respectively. (3) In terms of internal fixed stress distribution in different reconstructed models, the stress distribution of Model A and Model B screws was mainly concentrated in the body of the pedicle screw, while the peak stress of Model C and Model D screws was mainly concentrated in the tail of the screw. (4) It is suggested that Model A could obtain the best stability and reduce the risk of cage sinking and displacement. Model B could also provide better stability, and could be a choice for lateral fusion on the premise of ensuring stability and fixation. (5) Besides, Model C could achieve the same effect as Model D when the lateral road screw was selected. However, patients with lumbar instability should be cautious to choose unilateral lateral internal fixation, and excessive extension should be avoided to reduce the possibility of screw loosening and fixation fatigue. [ABSTRACT FROM AUTHOR]

Based on the analysis of the natural CuZn-SOD enzyme, a double enzyme complex 1,[Cu4(Hino）4(OH）2SO4(H2O）4]n, was synthesized by mixing the Hino ligand with the transition metal Cu(II). It was systematically characterized by SC-XRD,PXRD and FTIR.NBT photoreduction assay (NBT) showed that the IC50 value of complex 1 was 0.43μmol/L,indicating that complex 1 had excellent antioxidant properties. In vitro simulation of catecholase, the kcat value of complex 1 was 3.166×10~3 h-1,which can be used as a medium strength enzyme catalyst. [ABSTRACT FROM AUTHOR]

Objective: To explore the prognostic values of multi-b-value Diffusion Weighted Imaging (DWI) based on Magnetic Resonance Imaging (MRI) for the prognosis of severe chest trauma. Methods: From February 2018 to June 2020, 76 cases of patients with severe chest trauma (38 cases of open injury and 38 cases of closed injury) were selected for diagnosis and treatment. All patients were given conventional MRI scans and multi-b value DWI scans, Recorded the imaging quality and characteristics, and judged the predictive values. Results: All patients were examined within 3 days after thoracic trauma. The excellent and good rates of MRI images of patients with open injury and closed injury were 100.0 %, which met the diagnostic requirements. The multi-b value DWI D* value and f value of patients with open injury were significantly higher than those with closed injury, while the D value was significantly lower than that of patients with closed injury, and compared the difference were statistically significant (P<0.05). In the 76 patients, pathologically judged as the posterior thoracic ligament complex in 38 cases of grade 1 injury, 30 cases of grade 2 injury, and 8 cases of grade 3 injury; MRI diagnosed 39 cases of grade 1 injury, 31 cases of grade 2 injury, and 6 cases of grade 3 injury, and the accuracy of MRI diagnosis were 93.4 %. Conclusion: Based on MRI multi-b value DWI can clearly show the tissue damage of severe thoracic trauma, it can also truly reflect the characteristics of tissue microenvironment changes, and can effectively predict the damage of the posterior ligament complex. [ABSTRACT FROM AUTHOR]

HPLC fingerprints of different processing for Dipsacus asperoides were established, which provided a method for evaluating the quality of the products of Dipsacus asperoides. [Method] The HPLC Fingerprints of Dipsacus aspero ifles from fifteen batches were determined by high perlormance liquid chromatography. Cluster analysis ( CA) and principal component analysis ( PCA) were employed to analyze peak areas of 23 common peaks. [ Result] The HPLC fingerprint method was established, and 23 common peaks were selected with the similarity ranging from 0. 853 to 0. 990. The cluster analysis could classify these 15 batches of Dipsacus asperoides into 2 groups. [ Conclusion ] The method is accurate and reliable, and the processing method has great influence on the type and content of the active components in the continuation. [ABSTRACT FROM AUTHOR]

Aiming at the existing multi-modal learning which based on attention mechanism,this paper studied the self-association between the context of the text and the spatial positional relationship of the object area of the image.Based on the analysis of existing attention networks,this paper proposed to use SA and SRA to map the text information to the image object,and finally obtained the fusion feature output.Compared with other attention mechanisms,SA and SRA can better match text information to the image object area.The model is trained and verified on the VQAv2 dataset and achieves an accuracy of 64.01% on the VQAv2 dataset. [ABSTRACT FROM AUTHOR]

探讨自我导向学习与护理硕士专业学位研究生临床能力培养的关系,为护理硕士专业学位研究生临床培 养方案提供参考依据。方法 采用自我导向学习量表和临床能力自评量表,调查护理硕士专业学位研究生自我导向学习能力及临床能力,并分析其相关性。结果 自我导向学习能力总分为(228.78±16.62)分,临床能力总分为(247.26±25.73)分;自我导向学习能力中学习行为与临床科研能力、人际关系与组织管理能力呈正相关(r=0.25、0.28,P <0.05)。结论 护理硕士专业学位研究生的自我导向学习能力处于良好水平,临床沟通能力处于中偏上水平,自我导向学习对临床能力有积极影响,尤其是良好的人际关系对组织沟通管理能力有正性影响,有效的学习策略对临床科研能力的培养有帮助。 [ABSTRACT FROM AUTHOR]

探讨自我导向学习与护理硕士专业学位研究生临床能力培养的关系,为护理硕士专业学位研究生临床培 养方案提供参考依据。方法 采用自我导向学习量表和临床能力自评量表,调查护理硕士专业学位研究生自我导向学习能力及临床能力,并分析其相关性。结果 自我导向学习能力总分为(228.78±16.62)分,临床能力总分为(247.26±25.73)分;自我导向学习能力中学习行为与临床科研能力、人际关系与组织管理能力呈正相关(r=0.25、0.28,P <0.05)。结论 护理硕士专业学位研究生的自我导向学习能力处于良好水平,临床沟通能力处于中偏上水平,自我导向学习对临床能力有积极影响,尤其是良好的人际关系对组织沟通管理能力有正性影响,有效的学习策略对临床科研能力的培养有帮助。 [ABSTRACT FROM AUTHOR]

Objective: To study the efficacy of laparoscopic minimally invasive technology combined with spectrum irradiation in the treatment of appendicitis in children and its influence on the serum soluble intercellular adhesion molecule-1 (slCAM-1) and calcitonin (PCT) levels. Methods: 87 children with appendicitis who received therapy from February 2016 to February 2018 in our hospital were selected as research objects. According to random number table, those patients were divided into the observation group (n=42) and the control group (n=45). The control group was treated with traditional surgery, while the observation group treated with laparoscopic minimally invasive technique combined with spectral irradiation. The operation indexes (operation time, intraoperative bleeding volume, hospitalization time), intestinal function recovery (recovery time of bowel sounds, anal exhaust time, first defecation time), changes of serumslCAM-1, PCT level and incidence of adverse reactions were compared before and after treatment between the two groups. Results: After treatment, the operation time, intraoperative bleeding volume and hospitalization time in the observation group were significantly lower than those in the control group［(47.82± 8.33)min vs (56.97± 10.46)min, (46.97± 9.75)mL vs (90.72± 13.86)mL, (7.02± 2.41)d vs (11.84± 3.58)d］(P＜0.05). The recovery time of bowel sounds, anal exhaust time and first defecation time in the control group were significantly lower than those in the control group［(19.38± 4.32)h vs (25.82± 6.18)h, (16.98± 4.59)h vs (36.83± 7.29)h，(32.02± 5.82)h vs (40.17± 7.60)h］(P＜0.05). The levels of serum slCAM-1 and PCT were significantly lower than those in the control group［(180.27± 23.75) ng/L vs (197.06± 27.30), (0.92± 0.20)ng/L vs (3.87± 1.03)ng/L］(P＜0.05). The total incidence of adverse reactions was significantly lower than that in the control group［7.14%(3/42) vs 22.22%(10/45)］(P＜0.05). Conclusion: Laparoscopic minimally invasive technology combined with spectrum irradiation has a significant effect in the treatment of appendicitis in children. It can improve microcirculation, promote the recovery of intestinal function, reduce the level of serum slCAM-1 and PCT, and reduce complications, which is conducive to postoperative recovery. [ABSTRACT FROM AUTHOR]

Objective To compare the safety and outcome between total laparoscopic and laparoscopy-assisted synchronous resection for colorectal cancer patients with liver metastases. Methods The data of patients who underwent total laparoscopic or laparoscopy-assisted simultaneous resection of primary colorectal cancer and liver metastases in our hospital between December 2008 and December 2016 were collected and analyzed. The total laparoscopic surgery patients were matched 1∶2 to the laparoscopy-assisted surgery patients based on the propensity score. 22 patients were classified in the total laparoscopic group and 44 patients were classified in the laparoscopy-assisted group. The intraoperative conditions and postoperative outcomes of the two groups were compared. Results There was no difference in the preoperative baseline data between the two groups (P>0.05). The median operative time were 317.50 and 267.50 minutes in the total laparoscopic group and the laparoscopy-assisted group, respectively, and the median intraoperative blood loss were 100 and 200 ml, both with no statistically significant differences (P>0.05). There were 1 case of intraoperative blood transfusion in the total laparoscopic group and 5 cases in the laparoscopy-assisted group, with no statistically significant difference (P=0.650). The median postoperative hospital stay in the two groups were 11.0 and 10.0 days, the median postoperative defecation time were 4.0 and 4.0 days and postoperative complication rates were 13.6% and 20.5%, and none of these differences were statistically significant (P>0.05). However, no Clavien-DindoⅡ level and above complications occurred in total laparoscopic group. The median disease-free survival (DFS) were 15.0 and 15.7 months in the total laparoscopic group and the laparoscopy-assisted group, the overall survival (OS) were 25.9 and 37.6 months, respectively, with no statistically significant differences (P>0.05). Conclusion Laparoscopy-assisted approaches are similar, so the appropriate approach should be chosen according to the clinical condition and surgeon′s experience. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of cyclinD1 and matrix metalloproteinase-9 (MMP-9) in helicobacter pylori (HP) infected gastric carcinoma and its clinical significance. Methods: 80 patients with gastric cancer who were treated in Lanzhou University First Hospital from December 2016 to June 2018 were selected and their pathological tissues were collected. C-14 breath test and modified Giemsa staining were used to detect the status of HP infection. Immunohistochemistry was used to detect the expression of cyclinD1 and MMP-9 in gastric cancer tissues. The relationship between HP infection and cyclinD1, MMP-9 expression and clinicopathological features of patients with gastric cancer was analyzed. The correlation between HP infection and cyclinD1, MMP-9 expression in patients with gastric cancer was analyzed. Results: In 80 patients with gastric cancer, 56 cases were positive for HP infection (70.00%) and 24 cases were negative (30.00%). The positive rate of HP infection in gastric cancer patients with lymph node metastasis and depth of invasion with T3+T4 was higher than that in gastric cancer patients without lymph node metastasis and depth of invasion with T1+T2 (P<0.05). In 80 patients with gastric cancer, 45 cases were positive for cyclinD1 expression (56.25%), 35 cases were negative expression (43.75%), 65 cases were positive for MMP-9 expression (81.25%), 15 cases were negative expression (18.75%). The positive expression rates of cyclinD1 and MMP-9 in gastric cance patients with TNM stage for III+IV stage, low differentiation, lymph node metastasis and depth of invasion with T3+T4 were significantly higher than that of TNMstage for I+II stage, moderately high differentiation, no lymph node metastasis and depth of invasion with T1+T2 (P<0.05). The positive rate of cyclinD1 and MMP-9 in HP positive group was significantly higher than that in HP negative group (P<0.05). Pearson correlation analysis showed that HP infection was positively correlated with cyclinD1 and MMP-9 expression in patients with gastric cancer (P<0.05). Conclusion: HP infection in patients with gastric cancer is related to lymph node metastasis and depth of invasion. The expression of cyclinD1 and MMP-9 is related to TNMclinical stage, differentiation, lymph node metastasis and depth of invasion.Moreover, HP infection is positively correlated with cyclinD1 and MMP-9 expression in gastric cancer patients. [ABSTRACT FROM AUTHOR]

[Objective] The present paper aimed to investigate the impact of different beneficial bacteria on the micro-ecological environment of tobacco rhizosphere soil in long-term continuous cropping of flue-cured tobacco, aiming to provide insights for enhancing continuous cropping soil quality and mitigating obstacles associated with consecutive planting. [Method] The physical and chemical properties, enzyme activities, as well as structure and function of the microbial community in flue-cured tobacco rhizosphere soil were analyzed using pot experiment and high-throughput sequencing technology. The analysis was conducted after long-term continuous cropping of flue-cured tobacco with beneficial bacteria agents including Trichoderma harzianum agent T-22 (T1 treatment), Bacillus subtilis agent (T2 treatment), and a combination of T. harzanum agent T-22 and B. subtilis agent (T3 treatment). [Result] Compared with not applying beneficial bacteria (CK), the application of beneficial bacteria agents could enhance the availability of nutrients and enzyme activities in the rhizosphere soil of long-term continuous cropping flue-cured tobacco. Among the 10 environmental factors examined, available phosphorus (AP) content exhibited the highest contribution (4.97%) to bacterial community distribution in flue-cured tobacco rhizosphere soil. Additionally, Alkali-hydrolyzed nitrogen (AN) content demonstrated the highest contribution (6.91%) to fungal community distribution, while sucrase (SC) activity ranked the second with a contribution of 6.75%; Application of beneficial bacteria agents could increase the diversity index of microbial community structure and the number of unique OTU in long-term continuous cropping tobacco rhizosphere soil; Application of beneficial bacteria agents could increase the abundance, diversity index of microbial community and number of bacteria endemic OTUs in rhizosphere soil of long-term continuous cropping flue-cured tobacco, and change the abundance of indicator species in rhizosphere soil of long-term continuous cropping fluecured tobacco, among them, Pseudomonas and Mortierella were identified as the indicator species for Tl treatment, with Sphingomonas (12. 2%) and Mortierella (25.0%) exhibiting high abundance. The abundance of the main metabolic pathways in the rhizosphere soil of longterm continuous cropping tobacco was decreased by single application of bacteria, but not by single application of fungi. The abundance of bacteria metabolic pathway in rhizosphere soil of flue-cured tobacco could be increased by applying beneficial bacteria agent alone, while beneficial fungal agent along had the opposite effect. The abundance of fungal metabolic pathway in rhizosphere soil of flue-cured tobacco could be increased by applying beneficial fungal agent, beneficial bacteria agent and mixed agents. [Conclusion] The application of beneficial bacteria agents has positive impact on the micro-ecological environment of rhizosphere soil in long-term continuous flue-cured tobacco cultivation. Among them, T. harzianum T-22 demonstrates superior efficacy and can be effectively utilized for the prevention and control of obstacles associated with continuous cropping of flue-cured tobacco. [ABSTRACT FROM AUTHOR]

目的 探讨分化型甲状腺癌（DTC）患者全切术后、首次131I治疗前血清刺激性甲状腺球蛋白（ps-Tg）水平 对单纯肺转移的预测价值。方法 选择行首次131I治疗的DTC全切术后患者303例，于131I治疗1周后，行131I全身显 像（131I-WBS）及SPECT/CT融合显像，观察DTC肺转移情况，分为局限性肺转移、弥漫性肺转移和无转移。比较不同 转移情况患者131I治疗前的血清ps-Tg水平，采用受试者工作特征（ROC）曲线及最佳诊断界值点（DCP）评价ps-Tg对 DTC 全切术后单纯肺转移的预测价值。结果 无转移患者血清 ps-Tg 高于局限性肺转移和弥漫性肺转移患者（P 均<0. 01），局限性肺转移与弥漫性肺转移患者血清ps-Tg比较差异无统计学意义（P>0. 05）。局限性肺转移、弥漫性 肺转移患者血清 ps-Tg预测肺转移的 ROC曲线下面积分别为 0. 830、0. 847，最佳界值点分别为 28. 79、31. 18 μg/L， 其对应的灵敏度分别为75. 8%、95. 7%，特异度分别为87. 9%、89. 1%，准确度分别为86. 4%、89. 6%。结论 DTC患 者全切术后、首次131I治疗前的血清ps-Tg水平对单纯肺转移具有重要的预测价值。 [ABSTRACT FROM AUTHOR]

BACKGROUND: Development of bone tissue engineering provides a new method to solve bone defect repair. Scaffold material and structure construction are issues of concern. OBJECTIVE: To fabricate a silk fibroin and hydroxyapatite scaffold with biomimetic interconnected macropores structure using the paraffin-sphere leaching technology and to evaluate its possibility of cytocompatibility. METHODS: The scaffold with biomimetic interconnected macropores structure was made by the paraffin-sphere leaching technology. The structure of scaffold was observed by the stereomicroscope and scanning electron microscope. The pore size and elasticity modulus were calculated. Passage 3 rabbit adipose-derived mesenchymal stem cells were seeded into the scaffold. The cell viability was detected by live/dead staining at 48 hours after culture. The cell adhesion was observed by hematoxylin-eosin staining at 1 week of culture. The scaffold-cell composite was observed under scanning electron microscope at 3 days of culture. The cell proliferation was detected by the cell counting-kit 8 assay at 1, 3, 5 and 7 days of culture. Those cells cultured alone were considered as control group. RESULTS AND CONCLUSION: (1) Stereomicroscope showed the ivory silk fibroin/hydroxyapatite scaffold. Scanning electron microscope revealed pore structures in cross-section and longitudinal-section with good connectivity. The scaffold pore size was (362.23±26.52) μm and the elasticity modulus was (54.93±5.44) kPa. (2) Scanning electron microscope showed that adipose-derived mesenchymal stem cells adhered and stretched well in the pore wall and connected pore, secreted abundant extracellular matrix, and filled in the pores of silk fibroin/hydroxyapatite scaffold. (3) Hematoxylin-eosin staining results found that adipose-derived mesenchymal stem cells evenly adhered onto the inner wall of silk fibroin/hydroxyapatite scaffold, and proliferated well. (4) Live/dead staining revealed a good viability of adipose-derived mesenchymal stem cells. (5) Cell counting-kit 8 assay results showed the good proliferation of adipose-derived mesenchymal stem cells on the scaffold. (6) To conclude, the silk fibroin/hydroxyapatite scaffold possesses good pore size and cytocompatibility. [ABSTRACT FROM AUTHOR]

[Objective] The quality of Lepidium meyenii Walp. in different areas of Yunnan province was evaluated according to the contents of the effective substances ( polysaccharide, total alkaloid and macamides) of L. Meyenii. A multi-index evaluation system was established. [Method]The contents of polysaccharide, total alkaloid and macamides were determined by anlhrone-sulfuric acid colorimetry, acidic dye colorimetry and high performance liquid chromatography, respectively. [Result]The results showed that the effective substances contents of L. Meyenii from different areas in Yunnan province were significantly different. The contents of polysaccharide, total alkaloids and total macamides were the highest in the Deqin area, which were 8.6 %, 3. 18 mg/g and 2.46 mg/g, respectively, and the quality of L. meyenii in Deqin and Weixi areas was significantly belter than that in other areas. [Conclusion ]The significant difference existing in the contents of the effective substances (polysaccharide, total alkaloid and macamides) of L. Meyenii. was related to the altitude and temperature of producing areas. [ABSTRACT FROM AUTHOR]

Parameter optimization of support vector machines has always been an important research direction. The quality of the parameters determines the classification accuracy and generalization ability of the support vector machine(SVM)to a great extent. Given that using the artificial fish swarm algorithm for optimizing the parameters of the SVM tends to hover near the optimal solution in the late stage, we put forward an improved artificial fish swarm algorithm. It uses velocity parameters instead of the artificial fish step and obtains optimal target and the optimal parameters of the SVM. Simulation results show that the proposed method has the advantages of fast convergence speed, high numerical accuracy and low dependence on initial values, as well as better performance and higher classification accuracy in SVM parameter optimization. It is an effective parameter optimization method. [ABSTRACT FROM AUTHOR]

Lab quality management is very important for the development of an enterprise, and the statistics method can improve effectively the lab quality control. Therefore, this paper firstly overviewed five statistical methods, including Z-ratio fraction, En value, Mest, F-test and control chart. Next, the characteristics and application in the lab quality control of these methods were analyzed. Lastly, based on actually experimental examples, the application of En value method in calibration equipment of combustible gas alarm , F-test method and Mest method in intermediate checks of balance, control chart method in lab monitoring analysis equipment were also introduced respectively in this paper. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically evaluate the economics of Aidi injection in treatment of liver cancer. METHODS: According to the inclusion and exclusion criteria, Medline, Wanfang database, Chinese scientific journal full-text database, China Biomedical Literature Database, CNKI, VIP database and Chinese journal full-text database were retrieved to screen the randomized controlled trial (BCT) of Aidi injection in treatment of liver cancer(patients in the control group were treated with conventional arterial chemoembolization, and the observation group received Aidi injection on the basis of transcatheter arterial chemoembolization). After extracting data and assessing the quality of the literature, meta-analysis(Meta analysis) of the remission rale and total effective rale of Aidi injection in treatment of liver cancer was conducted. Cost-effectiveness analysis was performed by using the multi-effects theory. BESULTS: Totally 20 literature were involved, including 1 420 patients. According to Meta analysis, the remission rate(OR = 1.83, 95% Cl = 1.46-2.29, P<0.00001) and total effective rate(OR =2.91,95% C7 = 2.21-3.78, P <0.000 01) of observation group were significantly higher than those of control group, with statistically significant difference. The results of the bias assessment showed that the bias of inclusion in the study was smal1.The cost-effectiveness analysis based on the multi-effects theory showed that, the treatment regimen of Aidi injection 60 ml x21 d, in intravenous infusion and with 28 d for one treatment cycle was more economica1.CONCLUSIONS: The effects of Aidi injection in treatment of liver cancer is significant and it is more economical. [ABSTRACT FROM AUTHOR]