Objective To analyze the status of clinical trials registration in disorders of consciousness (DOC) in recent 5 years and to provide reference and evidence support for clinical research of DOC. Methods The clinical trial data of DOC in recent five years through the ClinicalTrials. gov and Chinese Clinical Trial Registry (ChiCTR) registration platform were collected and analyzed. The methods of bibliometrics and contrast were adopted to analyze the status of clinical trials in consciousness disorder in recent five years in DOC from registr-ation quantities, type, contents, sponsors and other aspects. Results There were 131 records of clinical trial registrations of DOC in the world. 57 were done in China, which rated number one in the world, followed by France, the United States and Belgium, with 20 items, 13 items and 11 items respectively. There were 52 randomized controlled trials of DOC all over the world, 26 were in China, and there were 2 multi-regional clinical trial of DOC, Participating countries include Germany, Belgium, the United States, Ireland and the United Kingdom. The research contents of clinical trials on global DOC in recent five years mainly focus on the diagnosis, prognosis and treatment, while mainly on the prognosis and treatment in China. There were 59 sponsors all over the world, 33 were in China. The top 10 sponsors were mainly research centres, university and medical institutions, such as Liege University of Belgium, Hangzhou Normal University, the First Affiliated Hospital of Zhejiang University, the General Hospital of Massachusetts (MGH) and Hospices Civils de Lyon, etc. Conclusions From the above analysis, it is found that in terms of research methods, DOC clinical trials mainly focus on behavior, including Coma Recovery Scale Revised (CRS-R) and Nociception Coma Scale Revised (NCS-R), electrophysiology, functional imaging, neuromodulation technology and drug therapy, the research content is mainly to improve the diagnostic accuracy, detect consciousness, recover consciousness and evaluate prognosis. Some new directions such as olfaction, music therapy, animal assist therapy, genetics, biological circadian rhythms, metabolic spectrum and intestinal microbiota are also emerging. Domestic research closely follows the international development and provides clues for our research. At the same time, It needs to strengthen the multi-center cooperation among the international and regional organizations. [ABSTRACT FROM AUTHOR]