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Objective To investigate the influencing factors of acute kidney injury (AKI) in patients with severe acute pancreatitis (SAP). Methods A retrospective study was conducted to collect the clinical data of 66 patients with SAP, and they were divided into AKI group and non-AKI group according to whether they had AKI, and the risk factors of AKI in SAP patients were analyzed by logistic regression and receiver operating characteristic (ROC) curve, respectively. Results The overall age, acute physiology and chronic health status assessment (APACHEII.) scores of patients with SAP and AKI were higher than those without comorbidity, but diabetes mellitus was more common in patients without comorbidity (P<0.05). The results of stepwise regression analysis showed that increased APACHEII. score, SIRI, platelet/lymphocyte ratio (PLR), systemic immune inflammatory index (SII) and serum calcium were independent risk factors for AKI in SAP patients (P<0.05).< THE RESULTS OF ROC CURVE SHOWED THAT, IN ADDITION TO SERUM CREATININE, APACHE II. SCORE, SIRI INDEX AND SERUM CALCIUM LEVEL HAD CERTAIN DIAGNOSTIC VALUE FOR AKI IN PATIENTS WITH SAP, AMONG WHICH THE AUC OF APACHEII SCORE WAS 0.880 (95%CI 0.787~0.974, CUT-OFF VALUE 11.50 points), the AUC of SIRI index was 0.662 (95%CI 0.521~0.804, cut-off value 10.89), and the AUC of serum calcium level was 0.754(95%CI 0.627~0.881, cut-off value 2.07 mmol/L), P < 0.05; When the above three indexes were combined with serum creatinine, the diagnostic efficacy of AKI in patients with SAP could be further improved, and the AUC of serum creatinine + serum calcium was the largest, reaching 0.969 (95%CI 0.929~1.000, P<0.05). SIRI index and serum calcium level have diagnostic value for AKI in patients with SAP, and the combination of serum creatinine can improve the diagnostic efficacy of AKI, providing a new means for clinical identification of AKI in patients with SAP. [ABSTRACT FROM AUTHOR]

In order to explore the structural characteristics of Chinese aviation and high-speed rail integrated transportation network, cities was treated as nodes and established three weighted networks: a high-speed rail sub-network, an aviation sub-network, and a comprehensive air-rail transportation network by connecting cities with flight or high-speed rail services, with flight numbers and highspeed rail numbers as weights. Firstly,mean correlation, triangle betweenness centrality, and weighted harmonic centrality were used to analyze key nodes in different networks. Secondly,clustering coefficients and average shortest path lengths were used to analyze the small-world properties of the three networks. Thridly,the Newman algorithm was used to study the community structure of the three networks. Lastly,weighted network efficiency was used as an indicator to compare the robustness of the three networks. The results show that Beijing, Shanghai, Guangzhou, and Shenzhen ranked high in all three weighted centrality measures and were the most critical nodes in all three networks. All three networks had small-world properties, but only the high-speed rail sub-network had a modularity value greater than 0. 3, indicating significant community structures, which were divided into ten communities. The comprehensive airrail transportation network had a better weighted network efficiency, approximately 0. 32, which was the highest among the three networks. It also had the strongest robustness and the smallest change in weighted efficiency when nodes failed. It is concluded that the comprehensive air-rail transportation network integrates the complementary advantages of the high-speed rail and aviation networks and has better structural characteristics than single transportation networks. [ABSTRACT FROM AUTHOR]

Based on recent development in foundation model, parallel intelligence, decentralized science (DeSci), and other artificial intelligence (AI) technologies, from AI for Science (AI4S) to Science for AI (S4AI), this study discusses parallel sciences and digital scientists, and their impact and significance in paradigm shift for research and development as well as Industry 5.0 and intelligent industry, which demonstrate that paradigm shift is emerging and accelerating, and we must be prepared. [ABSTRACT FROM AUTHOR]

Urban logistics unmanned aerial vehicle(UAV) path planning is a core content of UAV mission planning system. In order to realize the path planning problem of logistics UAVs safely and efficiently, firstly, the environment modeling was carried out by using grid method. Considering the performance limitations of UAVs, the path planning model of multi-constraint logistics UAVs was established by taking the shortest path length, the height variation of UAVs and the minimum grid risk as targets. Secondly, in view of the problems existing in the traditional particle swarm optimization algorithm, Singer mapping was introduced to improve the initial particle distribution, linear adjustment of acceleration coefficients and maximum velocity, new updating strategy of particle position, and dynamic adjustment of inertia weight, and the improved particle swarm optimization algorithm was applied to solve the model. Finally, an example is given for simulation analysis. When the grid size is 5 meters, the path nodes are 5 and the cost function weights are 0. 1, 0. 4 and 0. 5 respectively, compared with the other four algorithms, the total generation value of the proposed algorithm is the best, which is reduced by 44. 5%, 3. 5%, 42. 8% and 30%, respectively. The results show that the model and algorithm in this paper are feasible and effective for UAV path planning. [ABSTRACT FROM AUTHOR]

Public health emergencies，represented by large⁃scale infectious diseases，are modern risks that pose life⁃threatening crises for human beings and bring social and cultural changes. Quarantine and isolation are crucial measures in epidemic prevention considered as a modern risk. Due to the regional lockdown，atomized modern individuals in urban areas are confined to the same community space and have developed spiritual connections and group identities，thus forming a risk community due to the common risks they face. Within the risk community，interpersonal solidarity and conflicts coexist，creating tensions caused by risk awareness. Externally，the risk community has clear boundaries but is also exclusive. In the Chinese context of risk response，the tension between the prudent expansion of the logic of state control and the narrowing of individual logic of defense at the boundary shapes the characteristics of this new form of interpersonal relationship，the risk community. [ABSTRACT FROM AUTHOR]

Short term prediction of sector traffic is the premise of accurately implementing sector traffic optimization and management measures. Based on the decomposition integration prediction methodology, a vibrational mode decomposition least square support vector machine (VMD-LSSVM) prediction model is established. Firstly, the VMD method is applied to decompose the traffic into several sectors. Then, the LSSVM model is used to predict the modes . The modal prediction results are added and integrated to obtain the final prediction value. The calculation results show that the prediction accuracy of the VMD-LSSVM model is 0.97 in 1—6 h and 0.94 in 7—12 h. Compared with the first mock exam model of autoregressive integrated moving average model (ARIMA), back propagation (BP) and LSSVM, the prediction accuracy of the VMD-LSSVM model 1—6 h increased by 11.5%, 7.8%, 4.3%, respectively, and 2.1%, 6.6%, 5.4% compared with compete ensemble empirical mode decomposition with adaptive noise (CEEMDAN)-LSSVM, CEEMDAN-BP and VMD-BP, respectively. Compared with 30 min and 15 min statistical scales, the prediction accuracy is improved by 6.6% and 19.8%, respectively. For the eight experiments of time universality, the prediction accuracy is more than 0.94. For the experiments of 27 sectors, the prediction accuracy of 24 sectors is more than 0.9. The example results show that the VMD-LSSVM model has good prediction performance and good universality, and it is feasible and effective for short-term prediction of sector traffic. [ABSTRACT FROM AUTHOR]

Objective To investigate whether sarcopenia before concurrent chemoradiotherapy is prone to grade≥3 acute adverse reactions (AAR) and shorten survival in patients with advanced esophageal squamous cell carcinoma (ESCC). Methods Data of advanced patients with pathologically diagnosed ESCC and CCRT (FP regimen) from August 2018 to July 2022 were reviewed retrospectively. Skeletal muscle mass and body composition were measured using pre-treatment CT images, and patients were divided into sarcopenia and non-sarcopenia groups. Grade≥3 AAR was diagnosed based on CTCAE5.0 and acute radiation injury criteria of the US RTOG. Risk factors for developing grade≥3 AAR were analyzed, and survival rates were calculated by Kaplan-Meier method. Results Among 132 patients with ESCC (87 in the sarcopenia group and 45 in the non-sarcopenia group), 23(17.4%) experienced grade≥3 AAR. In multivariate regression analysis, independent risk factors for grade ≥3 AAR included the following: sarcopenia (OR: 6.034, 95%CI: 1.206-30.190, P=0.029), decreased SMD (OR: 0.693, 95%CI: 0.492-0.976, P=0.036), decreased SMI (OR: 0.841, 95%CI: 0.721-0.982, P=0.028), and increased FMI (OR: 2.433, 95%CI: 1.194-4.958; P=0.014). The OS rates were 16.01 months (95%CI: 14.89-17.13) in the sarcopenia group and 19.27 months (95%CI: 14.45-24.09) in the non-sarcopenia group (χ2 =5.326, P=0.021) as well as 14.86 months (95%CI: 11.30-18.42) for patients with grade≥3 AAR and 16.67 months (95%CI: 14.91-18.43) for patients with grade 0-2 AAR (χ2 =5.47, P=0.019). Among patients with grade≥3 AAR, the OS rates were 12.13 months (95%CI: 10.15-14.11) in the sarcopenia group and 18.69 months (95%CI: 12.85-21.88) in the non-sarcopenia group (χ2 =4.466, P=0.035). Conclusion Sarcopenia, decreased skeletal muscle density, and increased fat mass are important predictors of grade≥3 AAR. The OS of patients with sarcopenia and grade≥3 AAR may be reduced. [ABSTRACT FROM AUTHOR]

This study aims to explore the effects of microplastic input and straw addition on soil nitrogen leaching in farmland. Fluvo-aquic soil and yellow-brown soil were taken as the research objects. Eight treatments were set for each soil, including control (CK), low microplastics (PE1), medium microplastics (PE2), high microplastics (PE3), straw (S), straw + low microplastics (S+PE1), straw + medium microplastics (S+PE2), and straw + high microplastics (S+PE3). A systematic investigation was made to clarify the effects of microplastic input on soil nitrogen leaching with/without the straw. The results showed that there was no significant difference in the TN leaching loss among PE1, PE2 and PE3 treatments in the fluvo-aquic soil with microplastics only, compared with the CK. In yellow-brown soil, PE1 treatment significantly increased the TN leaching loss. There was no significant difference in the TN leaching loss between PE2 and PE3 treatments. The addition of straw in the fluvo-aquic soil significantly reduced the leaching amount of NO3- -N, NH4+ -N and TN, which decreased by 31.15%, 13.45% and 15.26%, respectively, compared with the CK. The addition of straw in the yellow-brown soil significantly increased the leaching amount of TN, which increased by 22.56%. Compared with no straw treatment, the cumulative leaching loss of NO3- -N, NH4+ -N and TN under different concentrations of microplastic input in fluvo-aquic soil showed a decreasing trend, whereas, the low amount of microplastic input in the yellow-brown soil reduced the TN leaching loss, and the high amount of microplastic input increased the TN leaching loss. Partial least squares path model (PLS-PM) analysis showed that the addition of straw in the fluvo-aquic soil mainly affected nitrogen leaching via the pH of the leaching solution and NO3--N leaching loss, and the amount of added microplastics had no significant effect on nitrogen leaching. In the yellow-brown soil, the nitrogen leaching was affected by the leaching loss of NO3- -N and NH4+-N in the leaching solution. The microplastics mainly affected the nitrogen leaching for the leaching loss of NH4+ -N in the leaching solution. The research results can provide a sound basis for the control of the risk of microplastic pollution in farmland soil and the reduction of soil nitrogen leaching. [ABSTRACT FROM AUTHOR]

目的 探讨 PBL 教学法结合3D 打印技术在泌尿外科实习教学中的应用效果. 方法 选取 2021年9月至2022年6月该院泌尿外科实习的临床医学专业本科生72名, 按随机数字表法将其分为研究组 和对照组, 每组36名. 对照组采用传统教学方式, 研究组采用 PBL教学法结合3D 打印技术, 比较2组理论与 技能考试成绩, 并采用问卷调查学生的教学满意度. 结果 研究组理论考试及技能考试成绩高于对照组, 差异 有统计学意义(P<0.05). 研究组教学总满意度优于对照组, 差异有统计学意义(P<0.05). 结论 在泌尿外 科实习教学中应用 PBL教学法结合3D打印技术, 可提高学生理论水平、操作技能及教学满意度. [ABSTRACT FROM AUTHOR]

The rise of artificial intelligence for science (AI4S) has made it particularly important and urgent to ensure the openness, fairness, impartiality, diversity, and sustainability of scientific systems. This is significant to the discourse power and leadership of countries in global innovation and industrial revolution, and also affects the security, stability, and sustainable development of a community with a shared future for mankind. To address these challenges, AI4S needs to adopt new scientific organizational and operational methods. Decentralized science (DeSci) has emerged to vitalize AI4S and provide strong support, effectively addressing issues such as information silos, biases, unfair distribution, and monopolies in existing research systems, and promoting multidisciplinary, interdisciplinary, and transdisciplinary cooperation in science. This study defines the basic concepts, characteristics, and framework of DeSci, analyzes its current research and application status, and explores the implications and significance of DeSci for the further development of the scientific systems. [ABSTRACT FROM AUTHOR]

Objective To analyze the risk factors of upper gastrointestinal cancer and precancerous lesions, to construct a prediction model for high⁃risk population of upper gastrointestinal cancer, and to identify high⁃risk groups of upper gastrointestinal cancer. Methods The population group at age 40-69 who participated in the "Rural Upper Gastrointestinal Cancer Early Diagnosis and Treatment Project " in Yangcheng County, Shanxi Province from June 2020 to December 2021 were selected, and randomly divided into a training set (n=1,997) and a validation set (n=852), according to the inclusion and exclusion criteria with a ratio of 7 to 3, used for training and validation of the model, respectively. The chi⁃square test was used for univariate analysis, the factors with P < 0.2 were screened for the optimal subset of variables, and the combination of variables with the lowest akaike information criterion (AIC) was selected to construct a logistic regression model and establish a scoring scale. The receiver operating characteristic curve (ROC) was drawn and the discrimination of the model was evaluated according to the area under the curve (AUC). The calibration of the model was evaluated by the Hosmer⁃Lemeshow (H⁃L) test and the calibration curve. The clinical decision curve analysis (DCA) was used to evaluate the clinica applicability. Results A logistic regression prediction model for the high⁃risk population of upper gastrointestinal cancer and precancerous lesions was established based on five risk factors, including age, sex, smoking, hot food intake and family history of cancer. The AUCs of the training set and the validation set of the model were 0.759 (95%CI: 0.689-0.830) and 0.743 (95%CI: 0.606-0.880), respectively. The calibration curve combined with H⁃L test proved that the model had good calibration (P>0.05). According to the logistic regression model, a scoring scale model was established with a score ranging from 0 to 27 points. The higher the score, the higher the risk of disease. The AUCs of the training set and the validation set were 0.760 (95%CI: 0.690-0.829) and 0.748 (95%CI: 0.612-0.884), respectively. The calibration curve combined with the Hosmer⁃Lemeshow (H⁃L) test proved that the model had good calibration (P>0.05).The DCA indicated that the model had good clinical applicability. Conclusions The prediction model and scoring scale model of the high⁃risk population of upper gastrointestinal cancer and precancerous lesions, based on the five risk factors including age, sex, smoking, hot food intake and family history of cancer, have good predictive value, which are helpful for the screening of the upper gastrointestinal cancer population. [ABSTRACT FROM AUTHOR]

In order to realize the high-energy-efficiency operation of the gas pump heat pipe composite air conditioner in areas with large dry/wet bulb temperature differences, an evaporative condensation (spray/spray) device is added on the condensation side of the system, so that the system can extend the utilization time of natural cooling sources in summer high temperature seasons, reduce unit energy consumption. In the enthalpy difference laboratory, the indoor return air temperature is set to three working conditions of 24, 30, 35℃, and the outdoor temperature is adjusted every 5℃ from-10℃ to 45℃ under each indoor working condition, and record the cooling capacity, power consumption and other data of 100% load and 75% load. The results show that the evaporative condensation technology can reduce the condensing temperature, broaden the operating temperature range of the gas pump heat pipe mode, and reduce the operating energy consumption; the evaporation temperature of the system increases with the increase of the indoor return air condition. Under the indoor conditions of 24, 30, 35℃, PUE≤ 1. 33, 1.28, 1.25 were achieved respectively. Under 75% load rate, the composite air conditioner prototype can achieve PUE ≤1. 3, 1. 27, 1. 24, which has good energy-saving benefits. [ABSTRACT FROM AUTHOR]

报道1例在新疆医科大学第-附属医院内分泌科住院诊治的肥胖2型糖尿病患者, 使用 二联口服降糖药物治疗后, 血糖控制不达标, 加用司美格鲁肽治疗的经过。患者为 38岁男性, 因“发 现血糖升高3年”入院, 无明显口干, 多饮, 多尿, 消瘦“三多一少”症状, 无自发酮症酸中毒倾向, 完善 相关检查, 结果显示其空腹血糖 (FPG) 8.43 mmol/L, 糖化血清白蛋白 3.05 mmol/L, 糖化血红蛋白 (HbA1c ) 8.9 %, 抗胰岛细胞抗体, 抗酪氨酸抗体, 抗胰岛素自身抗体, 抗谷氨酸脱羧酶抗体均为阴性, 体重指数 (BMI) 32.3 kg/m², 诊断为 2型糖尿病合并肥胖。予以二甲双胍+阿卡波糖联合降糖治疗, 血 糖控制欠佳, 加用司美格鲁肽治疗, 空腹和餐后血糖达标, 体重下降, 脂肪肝程度减轻, 血脂谱改善. [ABSTRACT FROM AUTHOR]

The degree of mental workload is closely related to the work efficiency and the allocation of human resources and the occurrence of accidents of man-machine operation. Therefore, it is of great significance to study the state of operators􀆳 mental workload. In order to solve the problem that the classification effect of the existing mental workload recognition methods is poor due to the small number of samples in the training set, a cross-subject mental workload classification method based on instance selection for visual and operational task was proposed. Firstly, referring to a small amount of historical data of the target subject, an adaptive source domain training set was obtained by instance selection of the training set data of the electroencephalogram (EEG) data of other subjects, thereby the number of samples and the domain difference between the training sets and test sets was reduced. Secondly, principal component analysis was used to reduce the feature dimension of the adaptive training set and target test set. Finally, the adaptive training set principal component was used to establish a support vector machine classification model to identify the mental workload state of the test set samples. The results show that this method can improve classification efficiency while improving classification accuracy, and achieve fast and accurate mental workload state recognition. [ABSTRACT FROM AUTHOR]

Objective To investigate effects of inhibiting phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) signaling pathway on autophagy, apoptosis, the expression of Parkinson's disease (PD) characteristic protein α-synuclein (α-syn) and tyrosine hydroxylase (TH) in SH-SY5Y cells treated with 1-methyl-4- phenylpyridine (MPP+ ). Methods SH-SY5Y cells were treated with MPP+, PI3K/Akt activator insulin-like growth factor-1 (IGF-1) and PI3K/Akt inhibitor LY294002. CCK-8 was performed to measure the cell viability. Flow cytometry was used to detect cell apoptosis rate. Acridine orange (AO) staining was used to detect autophagic vacuoles. Western blot assay was used to measure protein levels of α-syn, TH, p62, microtubule-associated protein 1 light chain 3B (LC3B), p-mTOR, mTOR, pPI3K, PI3K, p-Akt and Akt. Results MPP+ intervention significantly reduced the survival rate of SH-SY5Y cells in a dose-dependent manner (P＜0.05). The survival rate of SH-SY5Y cells decreased and the apoptosis rate increased after MPP+ and IGF-1 treatment (P＜0.05). The autophagic vacuoles in cells decreased, the ratio of LC3BⅡ/Ⅰ decreased, and the level of p62 protein increased (P＜0.05). The level of TH protein decreased and the level of α-syn protein increased (P＜ 0.05). The ratios of p-PI3K/PI3K, p-Akt/Akt and p-mTOR/mTOR were increased (P＜0.05). The effect of LY294002 on SH-SY5Y cells was opposite to that of MPP+ and IGF-1, and LY294002 was able to reverse the effect of MPP+ on SH-SY5Y cells to a certain extent (P＜0.05). Conclusion Inhibition of PI3K/Akt/mTOR signaling pathway has a protective effect on MPP+ -induced SH-SY5Y cytotoxicity, which provides a new theoretical basis for the treatment of PD. [ABSTRACT FROM AUTHOR]

糖尿病足是糖尿病的严重并发症之一，其导致的高截肢率、高死亡率严重威胁人群健 康. 糖尿病足发病机制复杂，创面反复迁延不愈，是公认的三大慢性创面之一. 间充质干细胞以其自 我更新和多向分化的生物学优势，在促进糖尿病足创面愈合中展现出良好的临床应用前景. 该文综 述了间充质干细胞在糖尿病足创面治疗中的作用及其机制. 此外，检索并列举国内外间充质干细胞 治疗糖尿病足的最新临床试验研究，从基础到临床，从临床前研究到临床研究，全面展示了间充质干 细胞在糖尿病足全程治疗中的研究进展及临床应用中存在的问题. [ABSTRACT FROM AUTHOR]

BACKGROUND: At present, the biological functions and molecular changes of bone marrow mesenchymal stem cells in the tumor microenvironment of acute myeloid leukemia are still unclear. OBJECTIVE: To explore the changes in the biological function of bone marrow mesenchymal stem cells in acute myeloid leukemia and the role of acute myeloid leukemia conditioned medium by bioinformatics and experiment. METHODS: Differential genes were screened from GEO data sets, and enrichment analysis was performed. The protein-protein interaction network was constructed and the Hub gene was obtained. Bone marrow mesenchymal stem cells from patients with acute myeloid leukemia and healthy donors were cultured. Bone marrow mesenchymal stem cells from healthy donors were treated with acute myeloid leukemia conditioned culture solution. Each group was subjected to the adipogenic differentiation, osteogenic differentiation, staining of β-galactosidase, detection of the cell cycle, and validation of Hub genes. RESULTS AND CONCLUSION: (1) Gene expression data of bone marrow mesenchymal stem cells from acute myeloid leukemia patients and healthy donors were obtained from GSE84881, and 184 up-regulated genes and 140 down-regulated genes were screened. (2) The biological functions of enrichment mainly include cell cycle, adipocyte differentiation, cell metabolism, and MYC pathway. According to the Degree algorithm, 10 up-regulated Hub genes and 10 downregulated Hub genes were selected. (3) The cell in vitro experiment found that: compared with the control group, the surface antigen of acute myeloid leukemia mesenchymal stem cells did not change, but it showed enhanced lipid differentiation ability, weakened osteogenic differentiation ability, increased β-galactosidase positive cell number, altered cell morphology, arrested cell cycle, increased LGALS3 expression, and decreased MYC expression. Mesenchymal stem cells from healthy donors showed similar changes after being cultured in acute myeloid leukemia conditioned medium. (4) The results show that biological function of mesenchymal stem cells is altered in the acute myeloid leukemia microenvironment, which provides new insights into the interaction between mesenchymal stem cells and tumor cells. [ABSTRACT FROM AUTHOR]

The fundamental original intention of promoting the urbanization construction with the county as an important carrier is to promote the local citizenization of agricultural and animal husbandry migrant workers, and the first step is to enhance the local citizenization willingness of agricultural and animal husbandry migrant workers. Applying the theory of planned behavior to analyze, it is found that the willingness of local citizenization of agricultural and animal husbandry migrant workers is between active integration and avoidance retreat, and its willingness to local citizenization is the result of consideration based on behavioral attitudes, subjective norms, perceived behavior control, policies and systems and other factors. From the perspective of resilience, this paper puts forward strategies to enhance the resilience of individuals, families and communities, as well as strengthen the connection of their advantageous resources and build resilient communities, so as to improve the frustration coping ability of agricultural and animal husbandry migrant workers, enable them to be resilient, and promote their local citizenization. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum clusterin (CLU) and granule membrane protein 140 (GMP140) and coronary artery lesions and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods: 129 patients with AMI who were admitted to our hospital from January 2020 to December 2021 were selected as the AMI group. According to the number of coronary artery lesions, they were divided into single vessel lesion group (n=34), double vessel lesion group (n=50), and multi vessel lesion group (n=45). The patients were followed up for 6 months and divided into MACE group and non-MACE group according to whether MACE occurred. Another 55 healthy volunteers in the same period were selected as the control group. The clinical data of patients with AMI were collected, and the serum CLU and GMP140 levels were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the influencing factors of MACE in patients with AMI, and the predictive value of serum CLU and GMP140 levels on MACE in patients with AMI was analyzed by the receiver operating characteristic (ROC) curve. Results: Serum CLU and GMP140 levels in the AMI group were higher than those in the control group (P<0.05). The serum CLU and GMP140 levels in the single vessel disease group, double vessel disease group and multi vessel disease group increased in turn (P<0.05). 6 months after follow-up, the incidence of MACE in 129 patients with AMI was 25.58% (33/129). Multivariate Logistic regression analysis showed that elevated left ventricular ejection fraction was independent protective factor, increased age, ST segment elevation myocardial infarction, KILLIP grade≥III, elevated low density lipoprotein cholesterol (LDL-C), elevated CLU and elevated GMP140 were independent risk factors for MACE in patients with AMI (P<0.05). ROC curve analysis showed that the area under curve of MACE predicted by serum CLU and GMP140 levels in patients with AMI was greater than that predicted by CLU and GMP140 alone (P<0.05). Conclusion: Elevated serum CLU and GMP 140 levels in patients with AMI are associated with coronary artery lesions and MACE, and which may be an auxiliary predictor of MACE in patients with AMI. [ABSTRACT FROM AUTHOR]

BACKGROUND: In recent years, the interaction between stem cells and tumor in tumor microenvironment has become a hot topic. While few studies have reported the experiments of human umbilical cord mesenchymal stem cells in conditioned culture medium of human multiple myeloma cells. OBJECTIVE: To investigate the effects of conditioned medium of human multiple myeloma cells on proliferation, migration and differentiation of human umbilical cord mesenchymal stem cells. METHODS: Human umbilical cord mesenchymal stem cells were extracted by tissue block adherent method. At the same time, the supernatant of human multiple myeloma RPMI8226 and U266 cells was cultured and extracted to prepare conditioned culture medium. The cells were grouped according to different media: the control group was only cultured with L-DMEM complete culture medium. In experimental group, human umbilical cord mesenchymal stem cells were cultured with 20% RPMI8226 cell conditioned medium or 20% U266 cell conditioned medium and 80% L-DMEM complete medium. After 24 hours of culture, the proliferation of cells was analyzed by CCK8 assay, EDU, and crystal violet staining. The migration of cells was evaluated by the scrape method. Osteogenic and adipogenic induction experiments were used to detect cell differentiation. Real-time PCR was used to detect the mRNA expressions of cyclin genes p16 and p21 in cells. RESULTS AND CONCLUSION: The proliferation of cells in the experimental group was more than that in the control group (P < 0.05); the migration rate was higher than that in the control group (P < 0.05); the staining area of mineralized nodules was smaller than that of the control group (P < 0.05); and the positive staining area of lipid droplets was larger than that of the control group (P < 0.05); the mRNA expression of cell cycle genes p16 and p21 in the experimental group was lower than that in the control group (P < 0.05). These findings exhibit that conditioned culture medium of human multiple myeloma cells can promote the proliferation, migration, and adipogenic differentiation of human umbilical cord mesenchymal stem cells, and inhibit osteogenic differentiation. This may be associated with the inhibition of p16 and p21 gene expression. [ABSTRACT FROM AUTHOR]

近期, 以 ChatGPT 为代表的大模型技术正开启人类社会智能化的新纪元。研究人工智能成功案例背后 的技术原理, 探索人工智能驱动的科学研究（AI for Science, AI4S）新范式, 对促进我国科技进步、增强国 家竞争力具有十分重要的意义。文章首先以数学、物理学、生物学、材料科学领域为例, 简述 AI4S 的研究 进展。其次, 面向近年来最为成功的人工智能范例, 分析 AlphaFold 和 ChatGPT 的基本原理和关键技术。最 后, 在以上分析的基础上, 从算法、模型、数据、知识、人的因素等角度, 总结大模型时代人工智能技术发 展新趋势, 探讨 AI4S 研究新范式。. [ABSTRACT FROM AUTHOR]

In order to accurately grasp the changing law of air traffic flow and the inherent characteristics of the air traffic system, it is necessary to analyze the time series of air traffic flow based on fractal characteristics of complex networks. The air traffic flow data was collected, a complex network model was constructed using the visual graph method, and the network topology was analyzed. It was verified that the degree distribution of the network obeyed a power-law distribution, and the slope of the fitted straight line was - 2. 086, which proves that the network is a scale-free network with a single fractal features. It is verified that the minimum number of boxes required to cover all nodes in the entire network has a power-law relationship with the diameter of the box. The slope of the fitted line is - 0. 212 1, and the correlation coefficient is - 0. 872 2, which again proves that the network has monofractal characteristics. By verifying that the image of the network generalized fractal dimension with respect to the parameters is nonlinear, the slopes of the fitting lines are - 1. 942, - 1. 936, and - 1. 78, respectively, and the correlation coefficients are all above 0. 8. The fitting effect is good, which proves that the network has multifractal characteristics. By calculating the similarity of the power exponents of the network before and after renormalization, it is proves that the network has self-similarity. The results show that it is feasible and effective to apply the theory of complex network to analyze the time series of air traffic flow, which lays a foundation for further in-depth application research. [ABSTRACT FROM AUTHOR]

A nonlinear mapping model of hydraulic pump flow based on prior data was proposed to solve the problems of nonlinear flow and nonlinear load disturbance of hydraulic pump in variable speed electro-hydraulic flow matching system of truck crane. Firstly, the mathematical model of the motor, quantitative pump and hydraulic cylinder was built. Then, the relationship between the pressure, speed and volumetric efficiency of the hydraulic pump was measured through experiments, the volumetric efficiency cloud diagram was fitted, and the pump flow nonlinear mapping model was constructed. Finally, taking the luffing mechanism as the analysis object, the AMESim software was used to build a system simulation model, comparative simulation analysis of hydraulic pump flow nonlinearity and nonlinear load disturbance before and after flow compensation was carried out. The research results show that under the compensation of the hydraulic pump flow nonlinear mapping model, the system can compensate the motor speed, so that the output flow of the hydraulic pump does not change with the change of load pressure, when the load has 25 kN, 50 kN and 75 kN step fluctuations, the maximum flow fluctuation amplitude is reduced by 52.1%, 47.9% and 43.5% respectively, which verifies the effectiveness of the proposed flow nonlinear model and improves the control accuracy and motion stability of the luffing telescopic mechanism. [ABSTRACT FROM AUTHOR]

目的 探讨听乐治疗在早产儿早期干预中的应用效果。方法 选取2019年11月至2020年 10月就诊于南通大学附属妇幼保健院高危儿门诊的108例早产儿, 随机分为对照组和干预组, 各54例。对照 组采用常规的体格检查、早期干预和定期随访, 干预组在对照组基础上采用听乐治疗, 比较2组干预前后婴儿 运动表现测试(TIMP)和Gesell发育量表(GDS)评分等指标。结果 干预前, 2组GDS评分、纠正年龄、TIMP 评分及百分位比较, 差异无统计学意义(P >0.05)。干预后, 干预组粗大运动、个人社交、适应性评分高于对照 组, 而TIMP评分及百分位低于对照组, 差异有统计学意义(P <0.05)。结论 听乐治疗能有效改善早产儿运 动功能, 提高早产儿个人社交和适应能力。 [ABSTRACT FROM AUTHOR]

报道1例在新疆医科大学第一附属医院内分泌科就诊的2型糖尿病（T2DM）合并动脉硬 化性心血管疾病（ASCVD）患者使用胰岛素强化治疗后，转换为德谷胰岛素+司美格鲁肽治疗的诊疗 过程并进行文献复习。患者为 38岁男性，因“发现血糖升高 10年”入院，既往明确诊断为 T2DM。患 者有糖尿病并发症，糖尿病性视网膜病变（非增殖期），合并高血压、颈内动脉粥样硬化、慢性肾功能不 全，有吸烟史、高血压家族史。予以司美格鲁肽+德谷胰岛素联合口服降糖药物治疗，血糖控制平稳， 患者满意度高。司美格鲁肽能降低T2DM伴有ASCVD患者心血管事件的发生。 [ABSTRACT FROM AUTHOR]

该文报道1例重度肥胖患者应用胰高糖素样肽‐1受体激动剂（GLP‐1RA）联合手术成功 减重的治疗过程。患者女性，30岁，应用GLP‐1RA减重：2021年2月2日至2022年2月19日应用度拉 糖肽1.5 mg、1次/周，体重由145 kg降至130.5 kg，体重指数（BMI）由58.08 kg/m²降至52.84 kg/m² 减重 14.5 kg、BMI 下降 5.24 kg/m² ）；2022 年 2 月 23 日至 2022 年 4 月 24 日使用司美格鲁肽，起始剂量 0.25 mg、1 次/周，3 周后改为 0.5 mg、1 次/周，再过 3 周调整为 1 mg、1 次/周。体重由 130.5 kg 降至 127.45 kg，BMI 由 52.84 kg/m² 降至 51.05 kg/m² 减重 3.05 kg、BMI 下降 1.79 kg/m² ）；患者于 2022 年 5 月 9日发生一次胰腺炎，胰腺炎确诊之后、治疗期间以及治愈之前患者停用司美格鲁肽。患者经内科保 守治疗，胰腺炎痊愈后于2022年5月20日行减重手术，手术方式为胃大部切除术，术后恢复良好。继 续 应 用 司 美 格 鲁 肽 ，术 后 1 个 月 ，体 重 由 127.45 kg 降 至 112.45 kg，BMI 由 51.05 kg/m² 降 至 45.04 kg/m² 减重 15 kg、BMI下降 6.01 kg/m² ）。GLP‐1RA 在减重中具有很多优势，重度肥胖的患者可 通过减重手术使其获益，而减重手术前联合使用 GLP‐1RA可有效减轻重度肥胖患者的体重，减少极 重度肥胖患者因减重手术可能带来的并发症，提高减重手术的成功率。 [ABSTRACT FROM AUTHOR]

The Shaanxi-Gansu-Ningxia Border Region was a relatively developed area in animal husbandry during the War of Resistance Against Japanese Aggression, but the development of animal husbandry in the border region was confronted with a series of challenges, such as livestock freezing to death due to cold, starving due to lack of fodder, dying from epidemic diseases, or dying due to poor management. Based on this, the border area government, through many measures, such as controlling and preventing the spread of epidemic diseases, banning the killing and export of female livestock, planting and promoting pasture, breeding and improving livestock breeds, advanced the increase of livestock stock in this area to some extent, pushed forward its development of animal husbandry, and made due contribution to the increase of fiscal revenue. [ABSTRACT FROM AUTHOR]

Recognition of mental workload is considered to be of great significance to improve the work efficiency of operators and reduce human accidents. However, because the electroencephalogram (EEG) signal is collected by a multi-channel EEG cap and distributed in various frequency bands, the high complexity of the subsequent recognition model is attributed to the high dimension features obtained by feature extraction. In this regard, principal component analysis (PCA) is usually used to perform dimensionality reduction processing on high-dimensional feature vectors, but it is difficult to determine the value of the dimensionality reduction dimension. An adaptive dimensional optimization method based on principal component analysis was proposed. The high-dimensional features in the experimental data set were reduced to each dimension within the optimized dimension range using principal component analysis, and the classification accuracy of each dimension was plotted as a dimension-classification accuracy curve. The optimal dimensionality reduction dimension of the experimental dataset was determined by identifying the “elbow” of the curve, and this dimension was applied to the same experimental data set and then the mental workload recognition was performed on it. The results show that the method can accurately identify the optimal dimensionality reduction dimension commonly used in the same experimental data set, and effectively improve the recognition efficiency. [ABSTRACT FROM AUTHOR]

As an irregular MPI (Message Passing Interface) collective communication, Gatherv provides great flexibility for the description of parallel communication behavior, but its irregularity brings high implementation difficulties. Existing methods have some problems, such as outstanding communication hotspots, high memory overhead, low memory access efficiency, etc., which are difficult to satisfy the performance requirements of today's large-scale parallel applications. A Gatherv optimization method for large scale concurrency is proposed. Starting from the optimization level, buffer management and other key issues, the binomial tree model commonly used in the implementation of regular collective communication is applied to the implementation of Gatherv. Besides, a message chain scheduling is proposed to further reduce the overhead and improve the optimization effect. Test data shows that the proposed method can effectively solve the performance problems of the existing methods, and achieve efficient scalability of Gatherv performance under the condition of large-scale concurrency. [ABSTRACT FROM AUTHOR]

BACKGROUND: In recent years, relationship between the bone marrow microenvironment and the growth, survival and drug resistance of multiple myeloma cells has become a research hotspot for researchers. Few studies have evaluated the effects of bone marrow mesenchymal stem cells conditioned culture medium on multiple myeloma cell lines. OBJECTIVE: To investigate the effect of bone marrow mesenchymal stem cell conditioned medium on the proliferation of multiple myeloma cell lines. METHODS: Ficoll density gradient centrifugation and adherent method were used to purify bone marrow mesenchymal stem cells from healthy donors. The supernatants of 3-5 generations of bone marrow mesenchymal stem cells were collected in the culture medium. Ultrafiltration centrifuge tube was used to prepare bone marrow mesenchymal stem cell conditioned medium and to prepare 1640 complete medium containing 10% human bone marrow mesenchymal stem cell conditioned medium so as to induce the culture of multiple myeloma cell lines RPMI8226 and U266 for 48 hours. Cell proliferation was detected by MTT assay and EdU fluorescence staining. Cell apoptosis was detected by flow cytometry and PI fluorescence staining. Real-time PCR and western-blot assay were used to detect mRNA and protein levels of multiple myeloma cell lines BCL-2 and BTK. RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cell conditioned medium could promote the proliferation of multiple myeloma cell lines (P < 0.05), reduce the apoptosis rate of cancer cells (P < 0.05) and was associated with high mRNA and protein expression of BCL-2 and BTK (P < 0.05). The results showed that the bone marrow mesenchymal stem cell conditioned medium promoted the proliferation multiple myeloma cell lines. [ABSTRACT FROM AUTHOR]

The evaluation of the pesticide spraying efficiency of different plant protection equipments could provide theoretical and technical support for pesticide reduction and pest control on rice. The method used in this study was referred to an agricultural industry standard the determination method of pesticide deposition rate (NY/T 2677—2015). Experiments were carried out in the late rice field of direct seeding in Quanan town, Nanxiong City, Guangdong Province. The pesticide utilization rates and droplet parameters of manual sprayer, electric sprayer, and plant protection unmanned aerial vehicle (UAV) were analyzed. The results were as follows. There were significant differences in pesticide deposition rates of different sprayers at the same rice growth period, which showed as UAV>electric sprayer>manual sprayer. The average pesticide deposition rates of manual sprayer, electric sprayer, and UAV were 18.33%, 24.58%, and 35.84% respectively at the seedling stage, 24.72%, 35.28%, and 45.15% respectively at the closure stage, and 32.39%, 40.29%, and 52.42% respectively at the rupturing stage. On the other hand, there were significant differences in pesticide deposition rates of different stages of rice with the same sprayer, which was the rupturing stage>the closure stage>the seedling stage. The results of deposition distributions showed that the deposition values of different rice layers of UAV treatments decreased from top to bottom, and the droplet deposition was mainly concentrated on the upper and middle rice layers by using manual and electric sprayers. In addition, the droplet size results showed that the size of droplet sprayed by UAV was significantly smaller than that of manual and electric sprayer, and also better with the uniformity. Droplet density results indicated that the dispersion of UAV droplets was better than manual and electric sprayers. Compared with the traditional sprayers, the UAV greatly improved the pesticide deposition rate and the atomization effect of pesticide solution. [ABSTRACT FROM AUTHOR]

Objective To observe the preventive effect of intraperitoneal injection of hydroxy safflower yellow A (HYSA) on cerebral ischemia-reperfusion injury in rats and to explore its mechanism. Methods Sixty SD rats were randomly divided into the sham operation group, model group, butylphthalide group, low-dose HYSA group, and high-dose HYSA group, with 12 rats in each group. The rats in the sham operation group and model group were intraperitoneally injected with 0. 9% NaCl solution, the rats in the butylphthalide group were intraperitoneally injected with butylphthalide soft capsule suspension, the rats in the low-dose HYSA group were intraperitoneally injected with 5. 0 mg/mL HYSA, and the rats in the high-dose HYSA group were intraperitoneally injected with 10. 0 mg/mL HYSA, once a day. After five consecutive days, the rats in the model group, butylphthalide group, low-dose HYSA group and high-dose HYSA group were treated with small correction method for cerebral ischemia-reperfusion, and the rats in the sham operation group were not treated. Rats in each group were awake for 4 h after treatment, and the neurological function of rats in each group was scored by Longa score method. After treatment, the morphological changes of rat brains were observed by HE staining; Bax, Bcl-2, Caspase-3 and c-fos mRNA were detected by RT-qPCR; and Bax, Bcl-2, Caspase-3 and c-fos proteins were detected by Western blotting. Results The neurological function score of the model group was significantly higher than that of the other groups (all P<0. 05), and those of the high-dose HYSA group and butylphthalide group were significantly lower than that of the low-dose HYSA group (all P<0. 05). In the model group, the intercellular space of brain tissues increased significantly, the nucleus decreased and deeply stained, and the cell morphology was irregular. The cell morphology of the low-dose HYSA group was better than that of the model group, but some nuclei were still concentrated and deeply stained. In the high-dose HYSA group and butylphthalide group, cell necrosis was significantly improved, cell morphology returned to normal, and cells were arranged neatly. The relative expression levels of Bax, Caspase-3, c-fos mRNA and protein in the model group were significantly higher than those in the other groups (all P<0. 05), and the relative expression levels of Bcl-2 mRNA and protein were significantly lower than those in the other groups (all P<0. 05). The relative expression levels of Bax, Caspase-3, and c-fos mRNA and protein in the high-dose HYSA group and butylphthalide group were significantly lower than those in the low-dose HYSA group (all P<0. 05), and the relative expression levels of Bcl- 2 mRNA and protein were significantly higher than those in the low-dose HYSA group (all P<0. 05). Conclusion Intraperitoneal injection of high-dose HYSA (10. 0 mg/mL) has a preventive effect on cerebral ischemia-reperfusion injury in rats, which is equivalent to that of butylphthalide; the mechanism of HYSA for preventing cerebral ischemia-reperfusion injury in rats may be related to regulating the expression levels of Bax, Bcl-2, Caspase-3 and c-fos in the brain tissues. [ABSTRACT FROM AUTHOR]

BACKGROUND: The back morphology of patients with lumbar disc herniation presents characteristic manifestations. At present, the judgment of lumbar type is mainly through observation and qualitative description. Professor Feng Tianyou summed up the four steps of “lumbar types” from the perspective of observation: the lumbar curve becomes flat, the lumbosacral upward movement, the rotary basin-buttock, and the rotary waist and chest. OBJECTIVE: To measure the three-dimensional angulation at the turning point of low back curve between type-III/IV and type-I/II patients and analyze the feasibility of judging lumbar type by three-dimensional angulation. METHODS: A total of 110 hospitalized patients with lumbar intervertebral disc herniation were enrolled sequentially, including 70 cases of type-I/II patients and 40 cases of type-III/IV patients. The topographic map of the patient’s back surface was collected through the human spine morphology evaluation system. The analysis software was used to measure the patient’s three-dimensional angulation. The stability of three-dimensional angulation was preliminarily determined. The difference and diagnostic critical value of three-dimensional angulation between type-III/IV and type-I/II patients were calculated, and the authenticity of 3D angle formation was evaluated. RESULTS AND CONCLUSION: (1) The index was stable, and there was no statistical significance in the comparison of the three times for three-dimensional angulation measurement data (P > 0.05). (2) There was significant difference in three-dimensional angulation between type-III/IV and type-I/II patients. Coronal angulation of type-III/IV was 11.04° on average, which was much larger than that of type-I/II (median 1.24°). Sagittal angulation of type-III/IV was 9.02° on average, which was much larger than that of type-I/II (mean 2.96°). Axial angulation of type-III/IV was 9.65° on average, which was much larger than that of type-I/II (mean 3.01°). (3) According to the ROC curve, the diagnostic critical value of three-dimensional angulation (coronal, sagittal, and axial) in III/IV-type patients were 5.43°, 4.77°, and 4.83°, respectively. The authenticity of the three-dimensional angulation results was reliable. The coronal, sagittal, and axial angulation results showed that the sensitivity was 86.66%, 93.33%, and 86.66%; the specificity was 95.23%, 85.72%, and 90.47%. The Youden index was 0.818, 0.790, and 0.771. The total compliance rate was 91.66%, 88.88%, and 88.88%. (4) In this study, three-dimensional topographic map technology of human back surface was used to analyze the feasibility of judging the lumbar type by three-dimensional angulation. It was found that the index had good stability, especially could reflect the characteristics of the rotary basin-buttock, and the rotary waist and chest. [ABSTRACT FROM AUTHOR]

The water-soluble polysaccharide of Raphanus sativus L. (RSP) was extracted by ultrasonic extraction method. The effects of ultrasonic power, extraction time and material liquid ratio on extraction yield of RSP were investigated. Based on single factor experiment, the extraction process conditions of RSP were optimized by response surface method. The optimal extraction conditions of RSP were: ultrasonic power 230 W, extraction time 29 min, ratio of material liquid 1:25 g/mL. Under the condition, the yield of RSP was 2.80%. Five polysaccharide fractions (RSP50, RSP60, RSP70, RSP80 and RSP90) were obtained by fractional precipitation of RSP with ethanol of graded concentrations (50%, 60%, 70%, 80% and 90%). The 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical, total reducing ability, hydroxyl radical, and superoxide scavenging ability of each component were determined to compare their antioxidant activities in vitro. The study indicates that the RSP extract presents outstanding antioxidant activities. [ABSTRACT FROM AUTHOR]

[Objective]: Select japonica rice varieties that are suited for rice and shrimp co-cropping in Northern Jiangsu. Promote healthy and sustainable development of the green rice industry in rice and shrimp co-cropping model in this area. [Methods]: From 2018 to 2020, a variety comparison experiment was conducted in the rice and shrimp co-cropping field in Suyu District, Suqian City in Jiangsu Province, using 16 japonica conventional rice varieties (lines) as experimental materials. During the whole growing season, deep-water management was carried out to compare the growth period, lodging resistance, yield, and quality of each variety (line) . [Results]: Nanjing 5718, Xudao No.9, and Sidao No.16 had compact plants, strong lodging resistance, and average rice quality. Huaidao No.20 and Sidao No.17 had strong tillering ability and fast grain filling, with yields of 9 985.39 and 9 805.43 kg/hm², respectively, which were significantly higher than most varieties. Sidao 301 had higher yield of 9 614.49 kg/hm², with large, gleaming and great quality rice grains but longer growth period. [Conclusion]: Nanjing 5718, Xudao No.9, and Sidao No.16 had high promotion value in rice and shrimp co-cropping in Northern Jiangsu, and could be used as suitable japonica rice varieties with good quality. Huaidao No.20 and Sidao No.17 could be promoted as high-yield varieties. Sidao 301 could be planted in advance and promoted as a superior quality rice variety. [ABSTRACT FROM AUTHOR]

The ecological conservation and high-quality development of the Yellow River Basin is one of the national strategies for regional development. Cooperative management is considered as the fundamental principle, method and approach to achieve this strategy because of its powerful and integrated function. Some scientific issues closely relating to the policy mid technology should be paid more attention for better implementation of cooperative management. The paper described the characters of cooperative management very briefly first, and then, put forward some scientific questions from 5 aspects of soil and water conservation and ecological restoration, water resources conservation and the development based on the water available, adjustment of flow and sediment of the Yellow River mid the integrated control of "suspended river", ecological production and compensation for ecological conservation mid high-quality development. It listed and discussed these issues here for the improvement of policy making and the compatibility between policy and demands and to improve the functions of technologies mid the objectivity of evaluation in the process of development of this challenging strategy. [ABSTRACT FROM AUTHOR]

Triazole fungicides are widely used fungicides in the world. The vast majority of triazole fungicides are chiral pesticides with one or two chiral centers and two or four enantiomers. Based on the research results of triazole fungicides in recent years, this article summarized the chromatographic methods such as high performance liquid chromatography, supercritical fluid chromatography, capillary electrophoresis, gas chromatography, and convergence chromatography for the chiral analysis of 11 triazole fungicides with two chiral centers including epoxiconazole, paclobutrazol, triadimenol, bitertanol, propiconazole, difenoconazole, metconazole, diclobutrazol, cyproconazole, bromuconazole, and etaconazole. The research progress in the separation and determination of triazoles with different chiral centers can provide references for the separation, analysis, and in-depth study of triazole compounds with multiple chiral centers. [ABSTRACT FROM AUTHOR]

Addressing the challenges in teaching the Nernst equation in inorganic chemistry, this experiment introduces the cutting-edge zinc-air battery as a teaching model. By altering the concentration of oxidizing and reducing materials, students explore the key factors of the Nernst equation, enhancing their understanding of electrochemical processes. Simultaneously, the experiment incorporates flexible electronics technology, using carrageenan as a safe and environmentally friendly solid electrolyte to guide students in learning and constructing solid zinc-air batteries. The batteries are tested for voltage performance at various bending angles to assess their flexibility. Moreover, to foster creativity, students design and build various forms of solid zinc-air batteries to power electronic devices. This experiment is closely aligned with fundamental electrochemical knowledge and state-of-the-art technology, allowing students to deepen their understanding of the Nernst equation while gaining practical experience in creating flexible electronic devices. This approach sparks students' interest in electrochemistry and proves cost-effective with promising results. [ABSTRACT FROM AUTHOR]

Objectives: To overcome the limitation of the existed video synopsis methods which are unable to express the global trajectory of video object in multi‐camera environment, this paper proposes a multi-video synopsis method in geographic scene considering the virtual viewpoint area of camera. Methods: First, on the basis of video spatialization, the virtual viewpoint area of the camera in geographic scene is calculated. Then, based on the data organization of multi‐video objects, cameras are divided into multiple sets to obtain the virtual viewpoint areas of multi‐camera. Finally, multi‐camera video synopsis is achieved in the virtual geographic scene. Results: The simulation results show that the same video object captured by multiple cameras can be comprehensively expressed with less time, comparing to the play time accumulated by single ‐ camera video synopsis. Conclusions: The proposed method can express the global trajectory of video objects in multi‐camera environment, and get a higher time compression ratio than the single‐camera video synopsis method. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of Dahuang (rhubarb)extract in improving the permeability of the blood-brain barrier(BBB)in rats with cerebral infarction and to explore its mechanism. Methods Totally 180 specific pathogen-free(SPF)male SD rats were randomly divided into the sham operation group, model group, and rhubarb group, with 60 rats in each group. Rats in the model group and the rhubarb group were used to prepare cerebral infarction models by the classic longa's thread tethering method. On the day of modeling, the rhubarb extract in the rhubarb group was given intragastrically, and the rats in the sham operation group and the model group were given intragastric administration of normal saline, twice a day for continuous observation. We randomly selected 10 rats in each group on the first, third, fifth, seventh, and tenth days of observation. The Longa scoring method was used to score the neurological function of each group of rats, the formamide soaking method was used to measure the amount of Evans blue(EB)exudation in the rat brain tissues, and the real-time PCR was used to detect the Occludin mRNA in the cerebral infarction area of rats in each group. Results On the 1, 3, 5, 7, and 10 days after modeling, the neurological function scores of rats in the sham operation group were all 0 point. The neurological function scores of rats in the model group were higher than those in the sham operation group, and the neurological function scores of rats in the sham operation group were lower than those in the model group(all P<0. 05). The amount of EB exudation in the cerebral tissues of rats in the sham operation group was less, and there was no change at different time points; the amount of EB exudation in the brain tissues of the model group was higher than that in the sham operation group, and the amount of EB exudation in the brain tissues of the rhubarb group was lower than that in the model group(all P<0. 05). The relative expression of Occludin mRNA in the cerebral infarction area of rats in the sham operation group did not change significantly at various time points. The relative expression of Occludin mRNA in the cerebral infarction area of rats in the model group was lower than that in the sham operation group（P<0. 05）， and the relative expression of Occludin mRNA in the cerebral infarction area of mice was higher in the rhubarb group than in the model group(all P<0. 05). Conclusion Rhubarb extract can improve the BBB permeability of rats with cerebral infarction by intragastric administration, and the mechanism may be related to its prevention on the degradation of Occludin mRNA in the cerebral infarction area. [ABSTRACT FROM AUTHOR]

妇科是理论和实践互相渗透且紧密联系的一门临床学科。由于卵巢癌这一章节知识点相对复 杂且抽象,在实习中属于重点及难点内容,传统的教学方法有很多弊端。该文尝试性提出了参照2021年美国 国立综合癌症网络(NCCN)指南设计的卵巢癌的临床带教的综合性教学法。基于病例的教学法(CBL),综合运 用标本及多媒体技术,开展基于问题的教学法(PBL)。这种综合的教学模式的临床运用,使得实习生能在妇产 科的临床实习中熟练掌握卵巢癌的各种知识。 [ABSTRACT FROM AUTHOR]

SM3 cryptographic hash algorithm is a commercial cryptographic algorithm independently researched and developed by our country, which has high independent security. Currently, there is a lack of relevant research on applying SM3 to autonomous network message verification. The core network traffic is large, the flow authentication key maintenance is large, and the required delay is low. The message authentication function needs the support of a high-performance engine. For the first time, the HMAC-SM3 real-time acceleration engine solution for large-flow network messages is given, and the fast storage matching technology of message- key pair based on the storage address and the ordered output architecture under the multi-message out-of-order hash are designed. The 64-round calculation of the SM3 algorithm is streamlined on FPGA, which can calculate 64 message-key pairs at the same time, and can reach a maximum clock frequency of 172. 41 MHz and an average throughput of 65.18 Gb/s. Under the same experimental conditions, it is 34. 86 times the throughput of the existing serial HMAC-SM3. [ABSTRACT FROM AUTHOR]

To investigate the effect of probiotics combined with triple therapy on ( ) - related gastritis in children and its influence on inflammatory factors. 93 cases of related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-α (TNF-α), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of probiotics combined with triple therapy on (HP) - related gastritis in children and its influence on inflammatory factors. 93 cases of related gastritis in our hospital from January 2017 to June 2018 were selected, and they were divided into study group (n=47) and control group (n=46) according to the method of random number table. The control group was treated with triple therapy. The study group was treated with probiotics on the basis of the control group, the clinical effect, total score of clinical symptoms, inflammatory factors, HP eradication rate, incidence and recurrence of adverse reactions were compared. After 1 month treatment, the total clinical effective rate of the study group was 87.23% (41/47), which was higher than 69.57% (32/46) of the control group (P<0.05). The total score of clinical symptoms after 2 weeks and 1 month treatment and the levels of serum tumor necrosis factor-琢(TNF-琢), hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6) after 1 month treatment of the two groups decreased (P<0.05), and those of the study group were lower than those of the control group (P<0.05). The eradication rate of HP of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions and recurrence rate between the two groups (P>0.05). The curative effect of probiotics combined with triple therapy in the treatment of HP related gastritis in children is definite, which can improve the clinical symptoms and reduce the level of inflammatory factors with good drug safety in children. [ABSTRACT FROM AUTHOR]

Objective: Traditional disaster models focus on single disaster, deployed in various types of isolated business systems. For lack of considering complex chain relationships between different disasters, it's difficult to meet the requirements of disaster assistance analysis with the disaster cluster in multi-disaster coupling scenarios. Given the above problems, we propose a disaster model service chain orchestration method using disaster chain rules. In order to elaborate the proposed method, we take the earthquake as a primary disaster to compose a composite disaster scenario as an example, and prove the proposed method from three aspects: The construction of the logical disaster model service chain, the optimization and dynamic adjustment of the physical model service chain, and the web publishing of the disaster model service chain. Methods: The disaster chain theory is adopted to orchestrate the disaster model service chain. Firstly, the logic disaster model service chain is constructed based on the analysis requirements of disaster scenario and disaster chain rules. Secondly, the optimized quality of service(QoS) index evaluation system is adopted to select the optimal combined service link from the disaster model cluster to realize the simulation analysis function for complex disaster scenarios. In order to ensure the stability of the chain, a dynamic adjustment mechanism is proposed to solve the failure of model node in the chain. Finally, to support the interoperable processing of distributed heterogeneous disaster model cluster, a standardized web service chain publishing method is proposed. Results: Compared with the traditional isolated single disaster model, our method considers the complex chain relationship between different disasters based on the disaster chain theory and have the ability to provide multi‑disaster composite disaster simulation analysis function with higher flexibility, better scalability and stronger stability. Conclusions: The disaster chain rules provide a theoretical guarantee for the service chain orchestration method with strong flexibility and high intelligence. Besides, the main chain and the auxiliary chain are adopted to settle the problem of logic conflict caused by the circular structure of the disaster chain. Meanwhile, based on the QoS index evaluation system, the disaster model service chain optimization method and dynamic adjustment method are proposed to ensure efficient and stable response of distributed heterogeneous disaster model. In general, the proposed method can help realize the multi-hazard composite disaster situation analysis function and provide flexible, intelligent, and stable disaster analysis information to integrated emergency management. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of miR-141-3p on proliferation and migration of gastric cancer cells and nuclear factor-κB (NF-κB) signaling pathway. Methods Human gastric cancer cell line BGC-823 was cultured, and miR-141-3p mimetic (miR-141-3p mimics) was transfected into BGC-823 cells by lipofection. The miR-141-3p overexpressed BGC was constructed. Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detect the transfection effect. The proliferation of BGC-823 cells was determined by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Transwell assay was used to detect the effect of miR-141-3p on BGC-823 cell migration. The expressions of NF-κB p65, p-IKK-α and p-IKB-α protein in NF-κB signaling pathway were detected by western blot. Results Compared with the control group and the negative control group, the expression level of miR-141-3p in BGC-823 cells of the miR-141-3p group was (2.39±0.27), which was higher than (1.00±0.09) of the control group and (1.01±0.10) of the negative control group (P<0.05). The number of migrating cells in the miR-141-3p group was (47.64±5.65), which was lower than (106.22±12.14) in the control group and (110.40±12.26) in the negative control group (P<0.05). The expression levels of NF-κB p65, p-IKK-α and p-IKB-α protein in BGC-823 cells were down-regulated (P<0.05). Conclusion MiR-141-3p can inhibit the proliferation and migration of human gastric cancer BGC-823 cells, which may be related to the inhibition of NF-κB signaling pathway activation. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical effect of posterior debridement， titanium mesh supporting bone graft and internal fixation in the treatment of thoracolumbar tuberculosis complicated with kyphosis. Methods A total of 38 patients with thoracolumbar tuberculosis complicated with kyphosis were retrospectively analyzed. They were hospitalized in the FirstAffiliated Hospital of Kunming Medical University from June 2016 to June 2019. There were 20 males and 18 females with an average age of （37.9 ±5.6） years. During hospitalization， posterior debridement， titanium mesh supporting bone graft and internal fixation were performed. All patients were followed up for 6-30 months， with an average of （18 ±6.8） months. The operation time， intraoperative blood loss and intraoperative complications were analyzed. VAS score， JOA score， Frankel grade of spinal cord function， Cobb angle， erythrocyte sedimentation rate and bone graft fusion were compared among 1 month before and after operation and the last follow-up. Results The operation time was 150-330 min，with a mean of （287±42.5） min；blood loss was 200-500 mL，with a mean of （393±63.4） mL；no nerve or spinal cord injury occurred during operations. Postoperative abscesswas absorbed， tuberculosis symptoms disappeared without recurrence， an dno incision infection or nonunion occurred. VAS score was （1.30 ±0.57） in the last follow-up， which was significantly lower than that before operation （ ＜0.05） . The JOA score at the last follow-up was （24.80 ±1.67）， which was significantly higher than that before operation （9.35 ±4.44） . According to the Frankel classification of spinal cord function， there were 4 cases of grade E， 18 cases of grade D， 11 cases of grade C， 5 case of grade B and 0 case of grade A. After operation， 17 cases of grade D recovered to grade E， 10 cases of grade C to grade D， and 4 case of grade B to grade C. The average ESR was （36.65 ±13.86） mm/h at admission. The ESR was normal at 4 to 9 months after operation. All the intervertebral bone grafts were fused and the internal fixation was stable from 5 to 12 months after operation. The average time of bone graft fusion was （8.01 ±1.52） months. The Cobb angle at the last follow-up was （8.05±5.20） degrees， which was significantly lower than that of the control group before operation （32.40±19.31） degrees （ ＜0.05） . Conclusion Posterior debridement，titanium mesh supporting bone graft and internal fixation is effective and safe in the treatment of thoracolumbar tuberculosis with kyphosis. [ABSTRACT FROM AUTHOR]

[Objective】The objective of the paper is to evaluate fruit quality of pitaya cultivated in rocky desertification control area, to pro¬vide the theoretical basis for building the evaluation index systemof pitaya quality and to provide the theoretical guidance for development of pitaya industry in rocky desertification control area.【Method 】12 important quality indexes of fruit shape index, average single fruit weight, edible rate, soluble solids, soluble solids, soluble sugar, titratable acid, solid-acid ratio, sugar-acid ratio, protein, Vc and dietary fiber in red pitaya cultivated in plateau valley of typical karst rocky desertification in Guizhou were determined and analyzed by principal component analysis and clustering analysis.【Result】The accumulative contribution rate of three extracted principal components was up to 93. 508 '. The load value of fruit flavor indexes in three principal components was higher and the fruit flavor indexes focused on seven indexes of dietary fiber, soluble sugar, solid-acid ratio, protein, soluble solids, titratable acid and sugar-acid ratio. 15 pitayas groups were divided into three types based on clustering analysis and the quality score of 15 pitayas groups was N > K > F > H > L > G > I > C > B > E > A > M > 0 > D > J according to quality comprehensive evaluation. The fruit quality of pitaya with mediumfruit shape was the best overall, followed by lar¬ger fruit shape and small fruit shape.【Conclusion 】The flavor and taste of pitaya are the important factorr to evaluate fruit quality of pitaya in rocky desertification control aea. The fruit quality of three pitaya sizes is mediumfruit shape > larger fruit shape > small fruit shape. The built evaluation index system of pitaya quality has a certain guiding significance for development of pitaya industry in rocky desertification control area. [ABSTRACT FROM AUTHOR]

Aiming at the problems of high cutting force, fast tool wear and high cutting temperature of 316 stainless steel, improving the ma­chining performance, reducing the cutting force, optimizing cutting parameters and reducing the frictional resistance between the tool and the chip were studied in the research. The frictional test of the tool was researched under the orthogonal cutting parameters by the turning test method. The YW1 carbide tool was used to test the 316 stainless steel bar under dry cutting conditions, and the influence of cutting parame­ters on the friction characteristics between tool and chip was analyzed. Third Wave AdvantEdge finite element software was used to analyze the cutting process. The experiment resules indicate that the influence of three factors of cutting parameters on the friction coefficient, μ, be­tween tool and chip in the dry cutting environment is from large to small in order of feed, cutting speed, back feed. The optimum combination of cutting speed Vc(120 m/min) , feed rate f (0. 2 mnVr) , back feed ap(1 mm) is selected based on the minimum friction coefficient be­tween the tool and the chip. [ABSTRACT FROM AUTHOR]