Search

目的观察糖尿病合并脓毒症小鼠肠损伤特点，并初步探讨M1巨噬细胞在糖尿病合并脓毒症肠损伤中的作用。方法BKS-DB（Lepr ko/ko）和BKS-DB（Lepr wt/wt）雄性小鼠随机分为非糖尿病鼠假手术组（NDMS组）、非糖尿病鼠脓毒症模型组（NDMCLP组）、糖尿病鼠假手术组（DMS组）、糖尿病鼠脓毒症模型组（DMCLP组）4组，每组6只；细胞实验分为对照组（Sham组）、高糖组（HG组）、脂多糖组（LPS组）、高糖+脂多糖组（HG+LPS组）4组。采用盲肠结扎穿孔术（CLP）构建糖尿病合并脓毒症小鼠模型，观察小鼠肠组织病理损伤情况、肠组织 Occludin 和ZO-1蛋白表达量变化、巨噬细胞极化特征及炎症因子基因表达情况；采用高糖与LPS共刺激巨噬细胞，流式细胞学技术检测体外巨噬细胞极化变化，qPCR技术检测炎症因子基因表达量。结果CLP后12 h，DMCLP组小鼠肠组织病理损伤Chiu's评分显著升高，肠组织Occludin、ZO-1蛋白表达量降低（P＜0.05）；DMCLP组小鼠肠组织巨噬细胞数量明显增加，M1标志物iNOS、CRR7 mRNA表达显著升高，炎症因子TNF-α、IL-1β和IL-6 mRNA表达明显上升（P＜0.05）。体外细胞实验中，HG+LPS组M1巨噬细胞标志物CD86及炎症因子TNF-α、IL-1β和IL-6 mRNA表达显著升高（P＜0.05）。结论糖尿病合并脓毒症小鼠肠损伤较非糖尿病脓毒症小鼠更为严重，可能与高糖时巨噬细胞更易在LPS的作用下向M1极化有关，促进炎症因子表达有关。

Copyright of Journal of Educational Studies (1673-1298) is the property of Journal of Educational Studies Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China University of Petroleum is the property of China University of Petroleum and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Natural Disasters is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Single cell sequencing is a powerful new sequencing technology, which can analyze the genome, transcriptome and epigenome in a single cell. Based on single-cell sequencing, the different molecular and clinicopathological characteristics of tumor heterogeneity can be explored in colorectal cancer, which provide important insights into the early diagnosis, therapy and prognosis of colorectal cancer. This paper reviewed the progress of single-cell sequencing technology in colorectal cancer, so as to provide references for the identification of prognostic markers of colorectal cancer, the search for new therapeutic targets and and personalized therapy. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Oil Drilling & Production Technology / Shiyou Zuancai Gongyi is the property of Shiyou Zuancai Gongyi Bianjibu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Fuzhou University is the property of Journal of Fuzhou University, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Oil Drilling & Production Technology / Shiyou Zuancai Gongyi is the property of Shiyou Zuancai Gongyi Bianjibu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Resources & Environment / Nongye Ziyuan yu Huanjing Xuebao is the property of Journal of Agricultural Resources & Environment Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Fuzhou University is the property of Journal of Fuzhou University, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Currently, immunotherapy is considered as the fourth major modality of cancer treatment except surgery, chemotherapy and radiotherapy. The new therapeutic approach based on immune checkpoint inhibitors is a landmark innovation. Strategies considering checkpoint inhibitors have shown good anti-tumor effect by targeting cytotoxic T-lymphocyte-associated protein 4 ( CTLA-4) and programmed cell death protein 1 (PD-1) or programmed cell death ligand 1 (PD-L1). Moreover, DNA mismatch repair-deficient tumors appear to be potential candidates for these therapies. This review summarizes the discussion and oral presentations in the annual meeting of American Society of Clinical Oncology ( ASCO) and ASCO-gastrointestinal cancer (Gl) in 2016 and provides an update on immunotherapy in gastrointestinal cancers. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlated factors of fungal rhinosinusitis and to analyze its clinical features. Methods: A group of 150 patients with fungal rhinosinusitis treated by surgery and another group of 150 patients with chronic rhinosinusitis in our hospital were selected and their clinical data were analyzed and compared retrospectively. The multiple factor Logistic regression analysis and square test were used to analyze the clinical data of all the patients. The correlated factors and the clinical features of fungal rhinosinusitis were investigated. Gomori methenamine silver staining which was special for fungi was used to classify the pathological types of 150 patients with fungal rhinosinusitis. Results: Age（x1）, the course of the disease（x2）, haem-nasal discharge（x3）, headache（x4）, unilateral/bilateral sinus lesion（x5） and calcified plaque in CT scan（x6） were set as the concomitant variables respectively, and then we established the Logistic regression predictive equation for fungal rhinosinusitis, which was y=-8.714+1.201 x1+0.497 x2+4.576 x3+1.188x4+2.697x5+4.118 x6, P=exp（y）/[1+exp（y）]. The P value meant the probability of suffering fungal rhinosinusitis. Compared with chronic rhinosinusitis, the clinical features of fungal rhinosinusitis were female, over 40 years old, the course of disease <3 years, headache, haem-nasal discharge, unilateral sinus lesion and calcified plaque in CT scan（P<0.05）. Among the 150 patients with fungal rhinosinusitis, 46 cases were chronic invasive and 104 were non-invasive. Conclusions: The clinical features of fungal rhinosinusitis can be predicted by using the suitable logistic predictable equation and they are significant for the diagnosis of fungal rhinosinusitis. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Zhejiang University. Humanities & Social Sciences / Zhejiang Daxue Xuebao is the property of Zhejiang University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的研究腹腔镜手术治疗溃疡性胃穿孔的有效性及优势。方法纳入2014年2月至2018年2月本院收治的溃疡性胃穿孔患者86例,其中腹腔镜下胃穿孔修补术40例(腹腔镜组),开腹胃穿孔修补术46例(开腹组)。比较患者手术时间、术中出血量、术后引流量、肛门通气时间、术后6h疼痛视觉模拟评分、住院时间、住院费用及并发症发生情况。结果两组患者手术时间、住院费用比较差异无统计学意义(P>0.05),腹腔镜组术中出血量、术后引流量、肛门通气时间、术后6h疼痛视觉模拟评分、住院时间均低于开腹组(P<0.05)。腹腔镜组术后并发症发生例数小于开腹组(P<0.05)。结论腹腔镜手术治疗溃疡性胃穿孔较开腹手术具有创伤小、恢复快、并发症少等优势,值得推广应用。 [ABSTRACT FROM AUTHOR]

Objective: To study the correlation of children allergic conjunctivitis with allergic rhinitis and the clinical effect of nasal-eye joint prevention and cure. Methods: We retrospectively analyzed the clinic data of 300 cases of children with allergic conjunctivitis and 310 cases of children with allergic rhinitis. We firstly analyzed the correlation of allergic conjunctivitis with allergic rhinitis. All the patients were randomly divided into control group and observation group. The control group adopted the method of routine eye treatment, and the observation group got the Bright Nose nasal spray combined with artificial tears treatment. Compare the clinical curative effect and adverse reactions between the two groups. Results: (1) Of 300 cases allergic conjunctivitis, 50 cases (16.67%) complicated with allergic rhinitis. Of 310 cases of allergic rhinitis, 59 patients (19.03%) complicated with allergic conjunctivitis (P>0.05). (2) The 109 cases complicated with two diseases at the same time all had scraping smear detection of conjunctiva and nasal mucosa, and Eosinophils were detected in 60 cases (55.05%) of conjunctival smears blade and 67 cases (61.47%) of nasal mucosa smears blade (P > 0.05). (3) The total effective rate was in control group, significantly lower than the observation group (P<0.05). The symptom scores in the two groups before and after treatment, BUT and corneal fluorescein staining scores were statistically significant different (P<0.05, P<0.01) but after treatment the differences of the above index were statistically significant between the two groups (P<0.05). Conclusion: Allergic conjunctivitis in children with allergic rhinitis has certain relevance. The Bright Nose nasal spay combined artificial tears eye treatment had distinct clinical curative effect on allergic conjunctivitis children with allergic rhinitis. [ABSTRACT FROM AUTHOR]

目的探讨临时心脏起搏器在缓慢性心律失常患者外科手术围手术期植入的意义、可行性和安全性。 方法选取2010 年1 月至2017 年1 月当阳市人民医院接受临时心脏起搏器植入再手术的85 例缓慢性心律失常患者 作为观察组，选取同期未植入临时心脏起搏器直接手术的35 例缓慢性心律失常患者作为对照组，观察两组患者术中、 术后的临床效果及并发症发生情况。结果观察组85 例患者均顺利完成麻醉、手术，全组无心脏穿孔、血胸、血肿、电 极移位等临时心脏起搏器相关并发症发生。两组患者术中、术后在血压下降、心律失常、血氧饱和度下降、病死率方面比 较，差异均有统计学意义P<0.05）。结论合并缓慢性心律失常的外科手术患者术前植入临时心脏起搏器能切实提高 麻醉、手术安全性，降低并发症发生率，值得临床推广。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)