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由于基于40μm保偏光纤的商用光纤器件制作技术和保偏熔接技术尚不成熟,一般的保偏光纤参数测量方法很难直接应用。文章提出在1根40μm保偏光纤上完成超辐射发光二极管（SLD）耦合对接和光纤偏振器在线制作,构建出一套简单的偏光干涉装置,利用调制光谱可同时实现拍长和双折射温度系数的测量。文章分别从理论和实验上对测量方法进行了阐述和验证。所提方法同样适用于其他直径的保偏光纤参数测量。

文章首先介绍了掺铒光纤放大器（EDFA）的结构和工作原理,然后运用能级理论和激光原理,深入全面地分析了影响EDFA增益和噪声的主要因素,得出了EDFA增益和噪声与泵浦功率、泵浦方式、输入信号光功率和掺铒光纤长度等关系的一些重要结论,并且通过实验进一步验证了这些结论;提出了提高EDFA增益,减小噪声系数的方法;最后根据文中得出的结论,设计了一种高增益低噪声的C波段EDFA光路,该光路已经应用于工程实践中。

为降低OOFDM（光正交频分复用）系统中的高PAPR（峰均功率比）,文章提出了一种基于非对称限幅法的抑制算法,其核心思想是通过门限电平去除信号负项并对信号峰值进行限幅,产生满足OOFDM系统要求的正、实基带信号,同时联合滤波技术避免较大PAPR的出现。仿真结果表明,该方法既能有效地改善PAPR特性,又能保证系统获得可靠的误码率性能。

Objective To investigate the potential significance of FOXP3 expression in BRCA1/2-mutant breast cancer. Methods A total of 48 BRCA mutation carriers (16 with BRCA1 and 32 with BRCA2) and 78 age-matched non-carriers were included in this study. Immunohistochemistry was used to detect the expression of FOXP3 in breast cancer tissues. The FOXP3 RNA expression in 39 BRCA1, 36 BRCA2, and 948 non-carrier breast cancer patients from TCGA-BRCA and the correlation with homologous recombination deficiency scores were evaluated to validate the immunohistochemistry results. Results The FOXP3 positive rate was 43.8% (7/16) in BRCA1 mutation carriers, 59.4% (19/32) in BRCA2 mutation carriers, and 9.0% (7/78) in non-carriers. The FOXP3 positive rates in patients with BRCA1/2 mutant breast cancer were significantly higher than those in non-carriers (P=0.002; P<0.001). TCGA-BRCA results showed that the FOXP3 RNA level in BRCA1/2 mutant breast cancer was significantly higher than that in non-carriers (P=0.02, P=0.004). The FOXP3 RNA level was positively correlated with the homologous recombination deficiency score (Spearman R=0.30, P<2.2e-16). Conclusion Patients with BRCA1/2 mutant breast cancers have higher FOXP3 expression than non-carriers, and may be more sensitive to immunotherapy. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To discuss the effect of Xuebijing on brain tissue damage and immune imbalance of helper T lymphocyte 17 (Th17)/regulatory T lymphocyte (Treg) in cerebrospinal fluid (CSF) of the N-methyl-D-aspartate (NMDA) receptor encephalitis model mice, and to clarify its therapeutic effect. Methods: Sixty healthy male C57BL/6J mice were randomly divided into control group, model group, low dose of Xuebijing group, and high dose of Xuebijing group, and there were 15 mice in each group. Except for control group, the mice in the other three groups were injected with the antigen combined with immunostimulation to establish the NMDA receptor encephalitis models. The mice in low and high doses of Xuebijing groups were injected intraperitoneally with 5 and 10 mL·kg-1 of Xuebijing injection, respectively. HE staining was used to observe the pathomorphology of brain tissue of the mice in various groups; TUNEL assay was used to detect the apoptotic rates of the neurons in hippocampus CA1 region of brain tissue of the mice in various groups; enzyme-linked immunosorbent assay (ELISA) method was used to detect the levels of interleukin (IL)-6, IL-10, IL-17, and transforming growth factor β (TGF-β) in serum of the mice in various groups; flow cytometry was used to detect the percentages of Th17 and Treg cells in CSF of the mice in various groups; Western blotting method was used to detect the expression levels of retinoic acid-related orphan receptor γt (RORγt), forkhead box protein 3 (Foxp3), IL-10, and IL-17 proteins in brain tissue of the mice in various groups; immunohistochemistry method was used to detect the rates of IL-17 and Foxp3 positive cells in brain tissue of the mice in various groups. Results: The HE staining results showed that the hippocampus CA1 region of brain tissue of the mice in control group had a clear structure without obvious lesions; compared with control group, the mice in model group showed partial pyramidal cell shrinkage, elongation of apical dendrites, loss of a few neurons, and sparse tissue in the hippocampus CA1 region of brain tissue; compared with model group, the mice in low and high doses of Xuebijing groups showed that the damage of the cells in the hippocampus CA1 region of brain tissue was decreased, and the morphological recovery, more orderly arrangement, and more significant improvement could be seen in hippocampus CA1 region of the mice in high dose of Xuebijing group. The TUNEL assay results showed that compared with control group, the apoptotic rate of the neurons in hippocampus CA1 region of brain tissue of the mice in model group was significantly increased (P<0. 05); compared with model group, the apoptotic rate of the neurons in hippocampus CA1 region of brain tissue of the mice in low and high doses of Xuebijing groups were significantly decreased (P<0. 05); compared with low dose of Xuebijing group, the apoptotic rate of the neurons in hippocampus CA1 region of brain tissue of the mice in high dose of Xuebijing group was significantly decreased (P<0. 05). The ELISA results showed that compared with control group, the levels of IL-6 and IL-17 in serum of the mice in model group were significantly increased (P<0. 05), while the levels of IL-10 and TGF-β were significantly decreased (P< 0. 05); compared with model group, the levels of IL-6 and IL-17 in serum of the mice in low and high doses of Xuebijing groups were significantly decreased (P<0. 05), while the levels of IL-10 and TGF- β were significantly increased (P<0. 05); compared with low dose of Xuebijing group, the levels of IL-6 and IL-17 in serum of the mice in high dose of Xuebijing group were significantly decreased (P<0. 05), while the levels of IL-10 and TGF-β were significantly increased (P<0. 05). The flow cytometry results showed that compared with control group, the percentage of CD4+IL-17A+ Th17 cells in CSF of the mice in model group was significantly increased (P<0. 05), while the percentage of CD25+Foxp3+ Treg cells was significantly decreased (P<0. 05); compared with model group, the percentages of CD4+IL-17A+ Th17 cells in CSF of the mice in low and high doses of Xuebijing groups were significantly decreased (P< 0. 05), while the percentage of CD25+Foxp3+ Treg cells was significantly increased (P<0. 05); compared with low dose of Xuebijing group, the percentage of CD4+IL-17A+ Th17 cells in CSF of the mice in high dose of Xuebijing group was significantly decreased (P<0. 05), while the percentage of CD25+Foxp3+ Treg cells was significantly increased (P<0. 05). The Western blotting results showed that compared with control group, the expression levels of RORγt and IL-17 proteins in brain tissue of the mice in model group were significantly increased (P<0. 05), while the expression levels of Foxp3 and IL-10 proteins were significantly decreased (P<0. 05); compared with model group, the expression levels of RORγt and IL-17 proteins in brain tissue of the mice in low and high doses of Xuebijing groups were significantly decreased (P< 0. 05), while the expression levels of Foxp3 and IL-10 proteins were significantly increased (P<0. 05); compared with low dose of Xuebijing group, the expression levels of RORγt and IL-17 proteins in brain tissue of the mice in high dose of Xuebijing group were significantly decreased (P<0. 05), while the expression levels of Foxp3 and IL-10 proteins were significantly increased (P<0. 05). The immunohistochemistry results showed that compared with control group, the rate of IL-17 positive cells in brain tissue of the mice in model group was significantly increased (P<0. 05), while the rate of Foxp3 positive cells was significantly decreased (P<0. 05); compared with model group, the rates of IL-17 positive cells in brain tissue of the mice in low and high doses of Xuebijing groups were significantly decreased (P<0. 05), while the rates of Foxp3 positive cells were significantly increased (P<0. 05); compared with low dose of Xuebijing group, the rate of IL-17 positive cells in brain tissue of the mice in high dose of Xuebijing group was significantly decreased (P<0. 05), while the rate of Foxp3 positive cells was significantly increased (P<0. 05). Conclusion: Xuebijing can effectively ameliorate the brain tissue injury, regulate the cytokine levels, and intervene in immune imbalance of Th17/Treg in the mice with anti-NMDA receptor encephalitis. [ABSTRACT FROM AUTHOR]

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Organic liquid hydrogen storage is a promising hydrogen storage method.Studying the catalytic mechanism of hydrogen storage-release at the atomic level is an important way to find efficient and low-cost catalysts.The reaction mechanism of stepwise dehydrogenation of methylcyclohexane (MCH) to toluene under the catalysis of transition metal dimer ion Ni Ti+was studied by density functional theory (DFT) method,and the energy changes of reactants,intermediates and products were investigated.The wave function analysis method was used to observe the change of atomic charge during the reaction,and the properties such as the density of states (DOS) of the initial compound were analyzed.The results show that the reaction between Ni Ti+and methylcyclohexane is an exothermic reaction on the mixed potential energy surface.The three dehydrogenation molecular mechanisms are similar.The overall exothermic heat of the reaction is-12.19 kcal·mol-1.The intermediates methylcyclohexene and methylcyclohexadiene were obtained,which were consistent with the experimental results.The rate-determining step of the whole reaction is IM10→TS10 during the third dehydrogenation reaction. [ABSTRACT FROM AUTHOR]

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Occupational Health & Emergency Rescue is the property of Occupational Health & Emergency Rescue Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Considering that the problems of low efficiency and credibility in traditional honey traceability, this study constructed a solution that combines blockchain technology and InterPlanetary File System technology to establish a highly reliable honey traceability system after analyzing the honey traceability standards. Firstly, this study introduced a hierarchical storage strategy to enhance the efficiency of on-chain information and traceability; Subsequently, this approach employs a multi-chain architecture to isolate data. It utilizes a proxy re-encryption scheme based on external random oracles, whereby ciphertext re-encryption is executed through smart contracts. Simultaneously, message authentication codes are integrated to effectively address challenges such as low information credibility, forgery, and potential privacy data leaks. Lastly, this paper proposed a pre-commit mechanism to prevent inconsistencies in data caused by sudden loads, that is, the scheme of "high-traffic package pre-commit, low-traffic supplementary on-chain".To assess the feasibility of the proposed solution, simulations and tests were conducted using Apache Bench tools. The results demonstrate that the scheme effectively achieves the chaining of basic data, controllable supervision, and credible traceability. Furthermore, it fulfills the multi-level requirements of enterprises, regulatory authorities, and users. [ABSTRACT FROM AUTHOR]

Psoriasis, a systemic immune-inflammatory disease, is often associated with metabolic syndromes such as obesity. As the most classical pro-inflammatory adipokine, leptin has received persistent attention in psoriasis. Currently, it is generally believed that leptin promotes the development of psoriasis. This article delves into the intricate relationship between leptin and the development of psoriasis, along withs associated metabolic complications. Additionally, the potential mechanisms by which leptin operates in the pathological processes of psoriasis, such as immune inflammatory activation, epidermal keratinocyte proliferation, differentiation and secretion of proinflammatory factors, and proliferation and dilatation of dermal papillary capillaries, are explored . [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

随着社会经济的快速发展, 水利工程建设逐渐向科学化、现代化迈进, 水利工程施工安全管理仍是水利 工程的重中之重. 由于水利工程具有“规模大、施工场地分散、自然环境恶劣”等特点, 导致水利工程安全事故时有 发生. 文章分析了水利工程建设中安全管理工作的重要性, 对当前水利工程施工安全管理中存在的问题进行分析, 提 出解决问题的相应对策及建议, 为水利工程的安全施工和水利事业的可持续发展提供参考依据. [ABSTRACT FROM AUTHOR]

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Objective To explore the self-rated health status and influencing factors of the elderly in rural areas of China, and to provide decision-making reference for relevant departments to formulate healthy aging strategies for the elderly in rural areas. Methods Using the data of China family panel studies (CFPS) in 2020, descriptive analysis, univariate analysis, and multivariate logistic regression were used to analyze the self-rated health status and its influencing factors of the elderly in rural areas of China. Results In total 72.6% of the 2 717 elderly in rural areas of China rated themselves as healthy. The age group of 60 to 74 years old (OR=0.694, 95%CI: 0.501-0.961), lower income (OR=0.503, 95%CI: 0.372-0.681), no smoking or no current smoking (OR=0.682, 95%CI: 0.538-0.865), and no alcohol or less alcohol now (OR=0.672, 95%CI: 0.491- 0.920) were associated with poor self-rated health status. Normal BMI index (OR=1.868, 95% CI: 1.298-2.687), по hospitalization within one year (OR=2.537, 95%CI: 2.015-3.194), no physical discomfort within two weeks (OR=4.205, 95% CI: 3.422-5.167), and no chronic diseases (OR=2.530, 95% CI: 2.051-3.121) were associated with better health status. Conclusion The self-rated health status of the elderly in rural areas of China is good, but it is still necessary to strengthen the economic support, improve the construction of medical and health service system, improve the family support and social support system, and actively carry out specialized health education for the elderly in rural areas to promote their health management and quality of life. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Nanjing University of Information Science & Technology (Natural Science Edition) / Nanjing Xinxi Gongcheng Daxue Xuebao (ziran kexue ban) is the property of Editorial Office of Journal of Nanjing University of Information Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Machine Tool & Hydraulics is the property of Guangzhou Mechanical Engineering Research Institute (GMERI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Agricultural Big Data is the property of Journal of Agricultural Big Data Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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AIM: To observe the differences in the regulatory effects of acupuncture and moxibustion on colonic metabolites and gut microbiota in healthy SD rats. METHODS: A total of 33 healthy SD rats were randomly divided into 3 groups: blank group, acupuncture group, and moxibustion group, with 11 rats in each group. The rats in blank group was placed in a supine position on the treatment table without interventions for 7 consecutive days. In acupuncture group, stainless steel acupuncture needles were used to puncture bilateral Shangjuxu and Tianshu points, which was retained for 15 min, and the intervention was performed for 7 consecutive days. In moxibustion group, mild moxibustion was applied by placing moxa sticks on both sides of Shangjuxu and Tianshu points, approximately 3~5 cm above the skin. The skin temperature was maintained at(45±5)°C for 15 min during each session, and the intervention continued for 7 days. After collecting colon tissues and fecal samples from the rats in each group, proton nuclear magnetic resonance ('H-NMR)technology was utilized to detect the metabolites in colon tissues, and the differential metabolites were screened and identified. Additionally, the abundance and diversity characteristics of intestinal flora, including differential flora, were examined by 16S ribosomal DNA (rDNA) sequencing. RESULTS: The results of metabolomics detection revealed that the levels of histidine, valine and butyric acid in the colons of rats in acupuncture group were significantly higher than those in blank group (P<0. 05). Additionally, the levels of choline and inositol in the colons of rats in moxibustion group showed significant increases 01 or PVO. 05). Furthermore, there was a significant increase in the levels of formic acid and acetic acid in the colons of rats in moxibustion group compared with acupuncture group (P<0. 05). The analysis of the diversity of intestinal flora showed that the Chaol index and abundance-based coverage estimator(ACE)of the intestinal flora in acupuncture group and moxibustion group were significantly increased compared with blank group (PV0. 05). At the phylum and genus levels, the abundance levels of some beneficial bacteria increased, while the abundance levels of some conditional pathogenic bacteria decreased. CONCLUSION: Acupuncture and moxibustion have different effects on the regulation of colonic metabolites and gut microbiota in healthy SD rats. Acupuncture is better at regulating gastrointestinal diseases caused by an imbalance of acid metabolism, while moxibustion is more suitable for metabolic diseases caused by abnormal lipid metabolism. Acupuncture and moxibustion have a beneficial regulatory effect on the intestinal microenvironment. Specifically, acupuncture has the potential to improve gastrointestinal diseases by influencing the structure and abundance of gut microbiota. [ABSTRACT FROM AUTHOR]

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BACKGROUND: The nervous system is highly protected by the blood-brain barrier and the blood-cerebrospinal fluid barrier and the development and administration of neurorestorative drugs are still challenging. Therefore, the clinical therapeutic effects of most drugs are limited. Direct administration to the nervous system through the cerebrospinal fluid route is also an important clinical treatment strategy, but there is currently no unified clinical application standard. OBJECTIVE: To explain the current status of cerebrospinal fluid administration and the indications, specific methods and precautions in clinical practice, thereby popularizing the application and improving the clinical efficacy. METHODS: The Expert Committee of Neurorestoratology of Beijing Medical Doctor Association and the Professional Branch of Neurorestoratology of Guangdong Medical Doctor Association organized and compiled this expert consensus by organizing relevant expert seminars from various disciplines across the country. RESULTS AND CONCLUSION: Direct administration to the nervous system through the cerebrospinal fluid route for neurorestorative therapy has a wide range of clinical indications and application prospects. However, attention should be paid to the safety and efficiency of cerebrospinal fluid administration, the combination of compound formulations, the maximum tolerated dose and full informed consent during the application process. [ABSTRACT FROM AUTHOR]

Copyright of Machine Tool & Hydraulics is the property of Guangzhou Mechanical Engineering Research Institute (GMERI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Machine Tool & Hydraulics is the property of Guangzhou Mechanical Engineering Research Institute (GMERI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To investigate the inhibitory effects of polyphyllin Ⅱ on the proliferation, migration, and in‐ vasion of lung cancer cells and their possible mechanism. Methods Lung cancer A549 cells in the logarithmic growth phase were divided into the high concentration group, medium concentration group, low concentration group, and control group. Polyphyllin Ⅱ of 3, 2, 1 µmol/L and the same amount of dimethyl sulfoxide solution were added for 24 h, respec‐ tively. Cell proliferation capacity （represented by cell proliferation activity) was detected by CCK-8. Cell migration ability （expressed as cell mobility) was measured by cell wound healing. Cell invasion ability （represented by the number of cells invaded) was detected by Transwell invasion assay. The expression levels of apoptosis-related proteins ［Cleave-Caspase3, Bax, Bcl-2, matrix metalloproteinase （MMP-2)］ were detected by Western blotting. Real-time fluorescence quantita‐ tive PCR was used to detect the expression of miR-16-5p. A549 cells in logarithmic growth phase were divided into the miR-16-5p inhibitor group, miR-16-5p NC group, and negative control group. Cells in the miR-16-5p inhibitor group and miR-16-5p NC group were transfected with miR-16-5p inhibitor and miR-16-5p inhibitor NC labeled with green fluores‐ cence and then were added with 2 µmol/L polyphyllin Ⅱ solution, respectively. Cells in the negative control group did not receive cell transfection and were only added with the same amount of dimethyl sulfoxide solution. At 24 h after interven‐ tion, the expression of miR-16-5p, apoptosis-related proteins and cell biological behavior were detected by the above meth‐ ods. Results The cell proliferation viability, cell migration rates and the numbers of invasive cells in the high, medium and low concentration groups and the control group sequentially increased, and significant differences were found between groups （all P<0. 05). Compared with the control group, the expression levels of Cleave-Caspase-3, Bax and miR-16-5p in‐ creased in the high, medium and low concentration groups, and the expression levels of Bcl-2 and MMP-2 protein de‐ creased, with the most significant changes in the high concentration group （all P<0. 05). The relative miR-16-5p expres‐ sion levels in the miR-16-5p inhibitor group, miR-16-5p NC group and negative control group were 0. 07 ± 0. 05, 1. 57 ± 0. 07 and 1. 00 ± 0. 03, respectively； the relative miR-16-5p expression was lower in the miR-16-5p inhibitor group than in the miR-16-5p NC group and negative control group （all P<0. 05). Cell proliferation viability, cell migration rates, the numbers of invading cells and the expression levels of Bcl-2 and MMP-2 protein were lower in the miR-16-5p NC group than in the miR-16-5p inhibitor group and negative control group； Cleave-Caspase-3 and Bax protein expression levels were higher than those of the miR-16-5p inhibitor group and negative control group （all P<0. 05)； there were no statistical‐ ly significant differences in the above indicators between the miR-16-5p inhibitor group and the negative control group （all P>0. 05). Conclusion Polyphyllin Ⅱ inhibited the proliferation, migration and invasion of lung cancer cells, and the mechanism may be related to the regulation of miR-16-5p expression. [ABSTRACT FROM AUTHOR]