1. Study of erythrocyte sedimentation in human blood through the photoacoustic signals analysis
- Author
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Argelia Pérez-Pacheco, Roberto G. Ramírez-Chavarría, Marco Polo Colín-García, Flor del Carmen Cortés-Ortegón, Rosa María Quispe-Siccha, Adolfo Martínez‑Tovar, Irma Olarte‑Carrillo, Luis Polo-Parada, and Gerardo Gutiérrez-Juárez
- Subjects
Whole human blood ,Aggregation ,Erythrocyte sedimentation ,Anemia ,Speed of sound ,Pulsed photoacoustic ,Physics ,QC1-999 ,Acoustics. Sound ,QC221-246 ,Optics. Light ,QC350-467 - Abstract
Introduction: In this study, we utilized the pulsed photoacoustic (PA) technique to analyze globular sedimentation in whole human blood, with a focus on distinguishing between healthy individuals and those with hemolytic anemia. Methods: Blood samples were collected from both healthy individuals (women and men) and those with hemolytic anemia, and temporal and spectral parameters of PA signals were employed for analysis. Results: Significant differences (p < 0.05) were observed in PA metrics between the two groups. The proposed spectral analysis allowed significant differentiation within a 25-minute measurement window. Anemic blood samples exhibited higher erythrocyte sedimentation rate (ESR) values, indicating increased erythrocyte aggregation. Discussion: This study underscores the potential of PA signal analysis in ESR assessment as an efficient method for distinguishing between healthy and anemic blood, surpassing traditional approaches. It represents a promising contribution to the development of precise and sensitive techniques for analyzing human blood samples in clinical settings.
- Published
- 2024
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