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1. Sleep apnoea phenotypes in women: A cluster analysis from the ESADA cohort

Author

Steiropoulos, P., Verbraecken, J., Petiet, E., Trakada, G., Fietze, I., Penzel, T., Ludka, O., Bouloukaki, I., Schiza, S., McNicholas, W.T., Ryan, S., Riha, R.L., Kvamme, J.A., Grote, L., Hedner, J., Zou, D., Hertegonne, K., Pevernagie, D., Bailly, S., Pépin, J.L., Tamisier, R., Hein, H., Basoglu, O.K., Tasbakan, M.S., Buskova, J., Joppa, P., Staats, R., Testelmans, D., Kalkanis, A., Gouveris, H., Ludwig, K., Lombardi, C., Parati, G., Bonsignore, M.R., Francesco, Fanfulla, Drummond, M., van Zeller, M., Randerath, W., Treml, M., Dogas, Z., Pecotic, R., Pataka, A., Mihaicuta, S., Anttalainen, U., Saaresranta, T., Sliwinski, P., Pepin, J.L., Riha, R., and Fanfulla, F.

Published
2024
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3. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author

Steiropoulos, P., Verbraecken, J., Petiet, E., Trakada, G., Montserrat, J.M., Fietze, I., Penzel, T., Ondrej, L., Rodenstein, D., Masa, J.F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W.T., Ryan, S., Riha, R.L., Kvamme, J.A., Hein, H., Schulz, R., Grote, L., Hedner, J., Zou, D., Pépin, J.L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O.K., Tasbakan, M.S., Varoneckas, G., Joppa, P., Tkacova, R., Staats, R., Barbé, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Bonsignore, M.R., Marrone, O., Petitjean, M., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Sliwinski, P., Bielicki, P., Gunduz, Canan, Basoglu, Ozen K., Kvamme, John Arthur, Verbraecken, Johan, Anttalainen, Ulla, Marrone, Oreste, Steiropoulos, Paschalis, Roisman, Gabriel, Joppa, Pavol, Hein, Holger, Trakada, Georgia, Hedner, Jan, and Grote, Ludger

Published
2020
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4. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author

Steiropoulos, P., Verbraecken, J., Petiet, E., Trakada, Georgia, Montserrat, J.M., Fietze, I., Penzel, T., Ludka, Ondrej, Rodenstein, Daniel, Masa, J.F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W.T., Ryan, S., Riha, R.L., Kvamme, J.A., Schulz, R., Grote, L., Hedner, J., Zou, Ding, Pépin, J.L., Levy, P., Bailly, Sebastian, Lavie, Lena, Lavie, Peretz, Hein, H., Basoglu, O.K., Tasbakan, M.S., Varoneckas, G., Joppa, P., Tkacova, Ra, Staats, R., Barbé, F., Lombardi, C., Parati, G., Drummond, Marta, van Zeller, Mafalda, Bonsignore, M.R., Marrone, O., Escourrou, P., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Sliwinski, P., Plywaczewski, R., Bielicki, P., Zielinski, Jan, Dieltjens, Marijke, Verbraecken, Johan A., Hedner, Jan, Vanderveken, Olivier M., Steiropoulos, Paschalis, Kvamme, John A., Saaresranta, Tarja, Tkacova, Ruzena, Marrone, Oreste, Dogas, Zoran, Schiza, Sofia, and Grote, Ludger

Published
2019
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5. Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea - The ESADA cohort

Author

Zou, Ding, primary, Grote, Ludger, additional, Basoglu, Ozen K., additional, Verbraecken, Johan, additional, Schiza, Sophia, additional, Sliwinski, Pawel, additional, Steiropoulos, Paschalis, additional, Lombardi, Carolina, additional, Hein, Holger, additional, Pépin, Jean-Louis, additional, Parati, Gianfranco, additional, McNicholas, Walter T., additional, Hedner, Jan, additional, Steiropoulos, P., additional, Verbraecken, J., additional, Petiet, E., additional, Trakada, Georgia, additional, Fietze, I., additional, Penzel, T., additional, Ludka, Ondrej, additional, Bouloukaki, I., additional, Schiza, S., additional, McNicholas, W.T., additional, Ryan, S., additional, Riha, R.L., additional, Kvamme, J.A., additional, Grote, L., additional, Hedner, J., additional, Zou, D., additional, Pevernagie, Dirk, additional, Bailly, S., additional, Pépin, J.L., additional, Tamisier, R., additional, Hein, H., additional, Basoglu, O.K., additional, Tasbakan, M.S., additional, Buskova, J., additional, Joppa, P., additional, Staats, R., additional, Testelmans, Dries, additional, Gouveris, Haralampos, additional, Ludwig, K., additional, Lombardi, C., additional, Parati, G., additional, Bonsignore, M.R., additional, Fanfulla, Francesco, additional, Drummond, M., additional, van Zeller, M., additional, Randerath, W., additional, Treml, Marcel, additional, Dogas, Z., additional, Pecotic, R., additional, Pataka, A., additional, Mihaicuta, S., additional, Anttalainen, U., additional, Saaresranta, T., additional, and Sliwinski, P., additional

Published
2023
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8. Hypertension treatment in patients with sleep apnea from the European Sleep Apnea Database (ESADA) cohort – towards precision medicine.

Author

Svedmyr, Sven, Hedner, Jan, Bonsignore, Maria Rosaria, Lombardi, Carolina, Parati, Gianfranco, Ludka, Ondrej, Zou, Ding, Grote, Ludger, Anttalainen, U., Bailly, S., Basoglu, O. K., Bonsignore, M. R., Bouloukaki, I., Buskova, J., Dogas, Z., Drummond, M., Fanfulla, Francesco, Fietze, I., Gouveris, Haralampos, and Grote, L.

Subjects
SLEEP apnea syndromes, SYSTOLIC blood pressure, ANTIHYPERTENSIVE agents, DIASTOLIC blood pressure, HYPERTENSION, BLOOD pressure
Abstract

Summary: We recruited 5,970 hypertensive patients with obstructive sleep apnea (OSA) on current antihypertensive treatment from the European Sleep Apnea Database (ESADA) cohort. The group was subdivided into those receiving monotherapy (n = 3,594) and those receiving dual combined therapy (n = 2,376). We studied how major OSA confounders like age, gender, and body mass index as well as the degree of sleep apnea modified office systolic and diastolic blood pressure. Beta‐blockers alone or in combination with a diuretic were compared with other antihypertensive drug classes. Monotherapy with beta‐blocker was associated with lower systolic blood pressure, particularly in non‐obese middle‐aged males with hypertension. Conversely, the combination of a beta‐blocker and a diuretic was associated with lower systolic and diastolic blood pressure in hypertensive patients with moderate–severe OSA. Systolic blood pressure was better controlled in female patients using this combined treatment. Our cross‐sectional data suggest that specific clinical characteristics and type of antihypertensive medication influence the degree of blood pressure control in hypertensive OSA patients. Controlled trials are warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Impact of sleep apnea on cardioembolic risk in patients with atrial fibrillation data from the ESADA cohort

Author

Pengo, M, Faini, A, Grote, L, Ludka, O, Joppa, P, Pataka, A, Dogas, Z, Mihaicuta, S, Hein, H, Anttalainen, U, Ryan, S, Lombardi, C, Parati, G, Pengo M., Faini A., Grote L., Ludka O., Joppa P., Pataka A., Dogas Z., Mihaicuta S., Hein H., Anttalainen U., Ryan S., Lombardi C., Parati G., Pengo, M, Faini, A, Grote, L, Ludka, O, Joppa, P, Pataka, A, Dogas, Z, Mihaicuta, S, Hein, H, Anttalainen, U, Ryan, S, Lombardi, C, Parati, G, Pengo M., Faini A., Grote L., Ludka O., Joppa P., Pataka A., Dogas Z., Mihaicuta S., Hein H., Anttalainen U., Ryan S., Lombardi C., and Parati G.

Abstract

BACKGROUND AND PURPOSE: An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF. METHODS: We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Spo2 and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA2DS2-VASc score. RESULTS: From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA2DS2-VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Spo2 81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively, P<0.05). CONCLUSIONS: These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.

Published
2021

10. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author

Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Riha R. L., Kotoulas S. -. C., Pataka A., Kvamme J. A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B. D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Parati G., Penzel T., Pepin J. L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S. E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., Zielinski J., Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Riha R. L., Kotoulas S. -. C., Pataka A., Kvamme J. A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B. D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Parati G., Penzel T., Pepin J. L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S. E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., and Zielinski J.

Abstract

Background: The impact of removing the upper airway lymphoid tissue and in particular, tonsillectomy, in adults with OSA has not been demonstrated in large populations. Aims: To compare the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between patients with OSA who had undergone previous tonsillectomy and those who had not. Methods: The 19,711 participants in this study came from the European sleep apnea database (ESADA) which comprises data from unselected adult patients aged 18–80 years with a history of symptoms suggestive of OSA referred to sleep centers throughout Europe. Results: There were no differences between the two groups in terms of sex ratio and age (146 patients with previous tonsillectomy vs. 19565 patients without). Patients who had undergone tonsillectomy had a lower body mass index (29.3 ± 5.2 kg/m2 vs 32.2 ± 6.6 kg/m2, p < 0.001), lower subjective sleep latency (17.1 ± 17.8 min vs 25.5 ± 30.4 min, p = 0.001), lower ODI (15.7 ± 18.3 events/hour vs 30.7 ± 26.1 events/hour, p < 0.001), and SpO2<90% time during sleep (21.8 ± 47.5 min vs 52.6 ± 80.8 min, p < 0.001). OSA patients with tonsillectomy had a lower prevalence of Type II diabetes mellitus (p = 0.001), hypertension (p < 0.001) and a higher prevalence of hyperlipidemia (p < 0.001) and were less likely to be commenced on CPAP (p < 0.001). Conclusion: In a large population of almost 20,000 OSA patients from across Europe, patients who had undergone tonsillectomy presented with less severe OSA at time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.

Published
2021

11. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author

Anttalainen, Ulla, Grote, L., Fietze, I., Riha, R. L., Ryan, S., Staats, R., Hedner, J., Saaresranta, T., Anttalainen, U., Barbe, F., Bonsignore, M. R., Basoglu, O., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I, Esquinas, C., Hayes, L., Joppa, P., Kurki, S., Kvamme, J. A., Tamisier, R., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pepin, J. L., Pretl, M., Roisman, G., Schiza, S. E., Schulz, R., Sliwinski, P., Steiropoulos, P., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vrints, H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R.L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M.R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J.A., Tamisier R., Lombardi C., Marrone O., McNicholas W.T., Montserrat J.M., Parati G., Pataka A., Penzel T., Pepin J.L., Pretl M., Roisman G., Schiza S.E., Schulz R., Sliwinski P., Tasbakan M.S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Ege Üniversitesi, and ESADA Study Collaborators

Subjects
Adult, Male, medicine.medical_specialty, Insomnia, Neurology, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Nocturnal, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Sleep Initiation and Maintenance Disorders, Internal medicine, mental disorders, Prevalence, Humans, Medicine, Hypoxia, Sleep Apnea, Obstructive, business.industry, Sleep Breathing Physiology and Disorders • Original Article, Sleep apnea, Middle Aged, Cardiovascular disease, Phenotype, Hypoxia (medical), medicine.disease, Circadian Rhythm, nervous system diseases, Europe, 030228 respiratory system, Otorhinolaryngology, Cardiovascular Diseases, Cohort, Female, Human medicine, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

WOS: 000482433800011, PubMed ID: 30467691, Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m(2)), and ODI (15 vs. 32/h). Conclusion High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms., European Union COST action B26; European Respiratory Society (ERS); ResMed Inc.; Philips Respironics Inc., The ESADA network has received support from the European Union COST action B26. The European Respiratory Society (ERS) supports the ESADA for the second period as a Clinical Research Collaboration (CRC) (2015-2017 and 2018-2020). Unrestricted seeding grants from ResMed Inc. and Philips Respironics Inc. for establishment of the organization and the database are gratefully acknowledged.

Published
2018
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13. Sleep apnoea management in Europe during the COVID-19 pandemic – Data from the European Sleep Apnoea Database (ESADA)

Author

Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, Testelmans, D, Grote L., McNicholas W. T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O. K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S. E., Bonsignore M. R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B. D., Ryan S., Kvamme J. A., Bailly S., Pepin J. -L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., Testelmans D., Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, Testelmans, D, Grote L., McNicholas W. T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O. K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S. E., Bonsignore M. R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B. D., Ryan S., Kvamme J. A., Bailly S., Pepin J. -L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., and Testelmans D.

Published
2020

14. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author

Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., Bielicki P., Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., and Bielicki P.

Abstract

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies.

Published
2020

15. Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Author

Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J. -L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O. K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J. A., Levy P., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Pataka A., Penzel T., Petiet E., Pepin J. L., Plywaczewski R., Pretl M., Riha R. L., Ryan S., Saaresranta T., Schulz R., Tasbakan M. S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Verbraecken J., Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J. -L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O. K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J. A., Levy P., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Pataka A., Penzel T., Petiet E., Pepin J. L., Plywaczewski R., Pretl M., Riha R. L., Ryan S., Saaresranta T., Schulz R., Tasbakan M. S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., and Verbraecken J.

Abstract

Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.

Published
2020

16. Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Author

Lombardi C, Parati G, Soranna D, Zambon A, Sliwinski P, Roisman G, Pepin JL, Schiza S, Riha R, Joppa P, Fietze I, Hedner J, Grote L, European Sleep Apnoea Database (ESADA) Collaborators (ESADA Collaborators: Anttalainen U, Barbé F, Bonsignore MR, Basoglu OK, Bielicki P, Dogas Z, Dorkova Z, Escourrou P, Hein H, Kvamme JA, Levy P, Marrone O, Masa JF, McNicholas WT, Montserrat JM, Pataka A, Penzel T, Petiet E, Pépin JL, Plywaczewski R, Pretl M, Riha RL, Ryan S, Saaresranta T, Schulz R, Tasbakan MS, Tkacova R, Staats R, Steiropoulos P, Varoneckas G, Verbraecken J), Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J.-L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M.R., Basoglu O.K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J.A., Levy P., Marrone O., Masa J.F., McNicholas W.T., Montserrat J.M., Pataka A., Penzel T., Petiet E., Pepin J.L., Plywaczewski R., Pretl M., Riha R.L., Ryan S., Saaresranta T., Schulz R., Tasbakan M.S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Verbraecken J., Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), University of Crete [Heraklion] (UOC), Royal Infirmary of Edinburgh, Univerzitnej nemocnice L. Pasteura Košice [Košice, Slovakia]. (UNLPK), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Gothenburg (GU), Sahlgrenska Academy at University of Gothenburg [Göteborg], European Sleep Apnoea Database (ESADA) Collaborators: Anttalainen U, Barbé F, Bonsignore Mr, Basoglu Ok, Bielicki P, Dogas Z, Dorkova Z, Escourrou P, Fietze I, Grote L, Hedner J, Hein H, Joppa P, Kvamme Ja, Levy P, Lombardi C, Marrone O, Masa Jf, McNicholas Wt, Montserrat Jm, Parati G, Pataka A, Penzel T, Petiet E, Pépin Jl, Plywaczewski R, Pretl M, Riha Rl, Roisman G, Ryan S, Saaresranta T, Schiza S, Schulz R, Sliwinski P, Pepin Jl, Tasbakan Ms, Tkacova R, Staats R, Steiropoulos P, Varoneckas G, Verbraecken J, SALAS, Danielle, Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, and Verbraecken, J

Subjects
Male, Pulmonary and Respiratory Medicine, Multivariate statistics, medicine.medical_specialty, obstructive sleep apnoea, Systole, Movement, [SDV]Life Sciences [q-bio], Blood Pressure, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Cohort Studies, 03 medical and health sciences, Sleep Apnea Syndromes, 0302 clinical medicine, Diastole, cardiovascular disease, Diabetes mellitus, Internal medicine, medicine, Humans, 030212 general & internal medicine, sleep disorder, Sleep disorder, Univariate analysis, business.industry, Confounding, Extremities, clinical epidemiology, Middle Aged, medicine.disease, Sleep in non-human animals, Europe, [SDV] Life Sciences [q-bio], Cross-Sectional Studies, Blood pressure, Databases as Topic, 030228 respiratory system, Cohort, Female, Sleep, business
Abstract

International audience; Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort.Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2 ) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency).Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP.Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.

Published
2020
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17. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author

Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gunduz, C, Hender, J, and Lepin, J

Subjects
Male, obesity, Databases, Factual, cholesterol, dyslipidemia, hypoxia, obesity, sleep apnoea, Gastroenterology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Hypolipidemic Agents, Oxygen saturation (medicine), Sleep Apnea, Obstructive, medicine.diagnostic_test, Sleep apnea, Middle Aged, Europe, Quartile, Cardiovascular Diseases, Cohort, Female, lipids (amino acids, peptides, and proteins), Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, medicine, Humans, Triglycerides, Dyslipidemias, hypoxia, Cholesterol, business.industry, Cholesterol, HDL, dyslipidemia, cholesterol, Cholesterol, LDL, ta3121, medicine.disease, Obesity, nervous system diseases, respiratory tract diseases, Cross-Sectional Studies, 030228 respiratory system, chemistry, Lipid profile, business, sleep apnoea, 030217 neurology & neurosurgery, Dyslipidemia
Abstract

Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.

Published
2018
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18. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author

Anttalainen, U., Barbé, F., Bonsignore, M.R., Basoglu, O., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Grote, L., Kent, B.D., Lena, Lavie, Lavie, P., Levy, P., Lombardi, C., Marrone, O., Masa, J.F., McNicholas, W.T., Montserrat, J.M., Parati, G., Penzel, T., Pépin, J.L., Plywaczewski, R., Pretl, M., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S.E., Schulz, R., Sliwinski, P., Staats, R., Steiropoulos, P., Tasbakan, M.S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., Zielinski, J., Riha, Renata L., Kotoulas, Serafeim – Chrysovalantis, Pataka, Athanasia, Kvamme, John Arthur, Joppa, Pavol, and Hedner, Jan

Published
2021
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19. Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA)

Author

Grote L, McNicholas WT, Hedner J, ESADA collaborators (Anttalainen U, Saaresranta T, Basoglu OK, Gunduz C, Tasbakan S, Bouloukaki I, Schiza SE, Bonsignore MR, Marrone O, Petitjean M, Roisman G, Fietze I, Laharnar N, Penzel T, Zou D, Kent BD, Ryan S, Kvamme JA, Bailly S, Pepin J-L, Tamisier R, Lombardi C, Parati G, Pataka A, Plywaczewski R, Sliwinski P, Pretl M, Riha R, Staats R, Steiropoulos P, Joppa P, Verbraecken J, Petiet E, Trakada G, Ludka O, Buskova J, Hein H, Drummond M, van Zeller M, Dogas Z, Galic T, Gouveris H, Mihaicuta S, Randerath W, Herkenrath S, Fanfulla F, Testelmans D, Ege Üniversitesi, Grote L., McNicholas W.T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O.K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S.E., Bonsignore M.R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B.D., Ryan S., Kvamme J.A., Bailly S., Pepin J.-L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., Testelmans D., Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, and Testelmans, D

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Databases, Factual, Polysomnography, medicine.medical_treatment, Pneumonia, Viral, Personnel Staffing and Scheduling, Disease, Covid, sleep laboratory, Betacoronavirus, 03 medical and health sciences, Sleep Apnea Syndrome, Sleep Apnea Syndromes, 0302 clinical medicine, Surveys and Questionnaires, mental disorders, Research Letter, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Continuous positive airway pressure, Pandemics, Sleep Medicine Specialty, Continuous Positive Airway Pressure, medicine.diagnostic_test, Coronavirus Infection, SARS-CoV-2, business.industry, Sleep apnea, COVID-19, Atrial fibrillation, medicine.disease, Comorbidity, Obesity, Telemedicine, Europe, 030228 respiratory system, Heart failure, Coronavirus Infections, business, Delivery of Health Care, management
Abstract

Sleep disordered breathing (SDB) is highly prevalent with a male to female predominance of two to one, and is more common in middle-aged and elderly subjects [1]. Affected patients often present with comorbidities such as obesity, cardiovascular disease (systemic hypertension, heart failure, atrial fibrillation), and diabetes mellitus Type II [2]. The strong overlap between the profile for SDB patients and the identified risk factors for adverse outcomes of COVID-19 infection that include age, male gender, and cardio-metabolic comorbidity [3] suggest that SDB patients may benefit from effective therapy if confronted with COVID-19 infection [4].

Published
2020
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20. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author

Gunduz, C., Basoglu, O. Kacmaz, Hedner, J., Bonsignore, M. R., Hein, H., Staats, R., Bouloukaki, I, Roisman, G., Pataka, A., Sliwinski, P., Ludka, O., Pepin, J. L., Grote, L., Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I, Penzel, T., Ondrej, L., Rodenstein, D., Masa, J. F., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Zou, D., Pepina, J. L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Tkacova, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Marrone, O., Petitjean, M., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Bielicki, P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Tıp Fakültesi, Gunduz C., Basoglu O.K., Hedner J., Bonsignore M.R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J.L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J.M., Fietze I., Penzel T., Rodenstein D., Masa J.F., Schiza S., Kent B., McNicholas W.T., Ryan S., Riha R.L., Kvamme J.A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M.S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., SALAS, Danielle, Biruni University [Istanbul] (BU), Ege university, University of Gothenburg (GU), Sahlgrenska University Hospital [Gothenburg], Università degli studi di Palermo - University of Palermo, CNR-IBIM : National Research Council-Institute of Biomedicine and Molecular Immunology, St. Adolf-Stift Hospital [Reinbek, Germany] (SASH), Hospital de Santa Maria [Lisboa], University of Crete [Heraklion] (UOC), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), General Hospital of Thessaloniki George Papanikolaou, Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), University Hospital Brno, St. Anne’s University Hospital [Brno], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), European Sleep Apnoea Database collaborators: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, D Rodenstein, J F Masa, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, D Zou, J L Pépin, P Levy, S Bailly, L Lavie, P Lavie, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, F Barbé, C Lombardi, G Parati, M Drummond, M van Zeller, O Marrone, M Petitjean, M Pretl, A Vitols, Z Dogas, T Galic, U Anttalainen, T Saaresranta, R Plywaczewski, P Bielicki, and European Sleep Apnoea Database Col

Subjects
Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Polysomnography, Hyperlipidemias, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 030204 cardiovascular system & hematology, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Prevalence, Internal Medicine, Humans, Medicine, cholesterol, hyperlipidaemia, hypoxia, obesity, sleep apnoea, Obesity, Sleep Apnea, Obstructive, Database, business.industry, Confounding, Sleep apnea, Odds ratio, Middle Aged, medicine.disease, respiratory tract diseases, [SDV] Life Sciences [q-bio], Europe, Cross-Sectional Studies, 030104 developmental biology, Quartile, Cardiovascular Diseases, Cohort, Female, Human medicine, business, Body mass index, computer
Abstract

Gunduz C, Basoglu OK, Hedner J, et al; onbehalf of the European Sleep Apnoea Databasecollaborators (Biruni University; Ege University;Gothenburg University; Sahlgrenska UniversityHospital; University of Palermo; CNR Institute ofBiomedicine and Molecular Immunology; St. AdolfStift; Hospital de Santa Maria; University of Crete;Antoine-Beclere Hospital; G. PapanikolaouHospital; Institute of Tuberculosis and LungDiseases; University Hospital Brno; St. Ann’sUniversity Hospital; Universite ́ Grenoble Alpes)Hyperlipidaemia prevalence and cholesterolcontrol in obstructive sleep apnoea: Data from theEuropean sleep apnea database (ESADA).J InternMed2019;286: 676–688.Background and objective.Obstructive sleep apnoea(OSA) and hyperlipidaemia are independent riskfactors for cardiovascular disease. This studyinvestigates the association between OSA andprevalence of hyperlipidaemia in patients of theEuropean Sleep Apnea Database (ESADA) cohort.Methods.The cross-sectional analysis included11 892 patients (age 51.9 12.5 years, 70% male,body mass index (BMI) 31.3 6.6 kg/m2, meanoxygen desaturation index (ODI) 23.7 25.5events/h) investigated for OSA. The independentodds ratio (OR) for hyperlipidaemia in relation tomeasures of OSA (ODI, apnoea-hypopnoea index,mean and lowest oxygen saturation) was deter-mined by means of general linear model analysiswith adjustment for important confounders suchas age, BMI, comorbidities and study site.Results.Hyperlipidaemia prevalence increased from15.1% in subjects without OSA to 26.1% in thosewith severe OSA,P

Published
2019
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21. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author

Gunduz, C. Basoglu, O.K. Kvamme, J.A. Verbraecken, J. Anttalainen, U. Marrone, O. Steiropoulos, P. Roisman, G. Joppa, P. Hein, H. Trakada, G. Hedner, J. Grote, L. Steiropoulos, P. Verbraecken, J. Petiet, E. Montserrat, J.M. Fietze, I. Penzel, T. Ludka, O. Rodenstein, D. Masa, J.F. Bouloukaki, I. Schiza, S. Kent, B. McNicholas, W.T. Ryan, S. Riha, R.L. Kvamme, J.A. Hein, H. Schulz, R. Grote, L. Hedner, J. Zou, D. Pépin, J.L. Levy, P. Bailly, S. Lavie, L. Lavie, P. Basoglu, O.K. Tasbakan, M.S. Varoneckas, G. Joppa, P. Tkacova, R. Staats, R. Barbé, F. Lombardi, C. Parati, G. Drummond, M. van Zeller, M. Bonsignore, M.R. Petitjean, M. Roisman, G. Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. Anttalainen, U. Saaresranta, T. Plywaczewski, R. Sliwinski, P. Bielicki, P. the European Sleep Apnea Database collaborators

Abstract

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies. © 2020 Elsevier B.V.

Published
2020

22. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author

Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, Dieltjens M., Verbraecken J. A., Hedner J., Vanderveken O. M., Steiropoulos P., Kvamme J. A., Saaresranta T., Tkacova R., Marrone O., Dogas Z., Schiza S., Grote L., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Hein H., Basoglu O. K., Tasbakan M. S., Varoneckas G., Joppa P., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Escourrou P., Roisman G., Pretl M., Vitols A., Galic T., Pataka A., Anttalainen U., Sliwinski P., Plywaczewski R., Bielicki P., Zielinski J., Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, Dieltjens M., Verbraecken J. A., Hedner J., Vanderveken O. M., Steiropoulos P., Kvamme J. A., Saaresranta T., Tkacova R., Marrone O., Dogas Z., Schiza S., Grote L., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Hein H., Basoglu O. K., Tasbakan M. S., Varoneckas G., Joppa P., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Escourrou P., Roisman G., Pretl M., Vitols A., Galic T., Pataka A., Anttalainen U., Sliwinski P., Plywaczewski R., Bielicki P., and Zielinski J.

Abstract

Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a subpopulation, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged ≤65 years, CGI scoring was generally better than in the elderly despite a similar degree of OSA (eg, ‘normal, not ill’ 24.2% vs 15.3%, p < 0.01, respectively). Independent predictors of CGI rating included age, BMI, AHI, ESS, cardio-metabolic comorbidities, and diagnosis based on polygraphy. CGI-improvement rating (Beta = −0.406, p < 0.01) was superior to sleep apnea severity or ESS-score (Beta = 0.052 and −0.021, p = 0.154 and 0.538 respectively) at baseline for prediction of good CPAP compliance at follow-up. Conclusions: CGI rating is confounded by gender, age class and the type of sleep diagnostic method. As OSA phenotypes differ, CGI may contribute as a clinical tool to reflect the significance of clinical disease.

Published
2019

23. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author

Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., and Bielicki P.

Abstract

Background and objective: Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 11 892 patients (age 51.9 ± 12.5 years, 70% male, body mass index (BMI) 31.3 ± 6.6 kg/m2, mean oxygen desaturation index (ODI) 23.7 ± 25.5 events/h) investigated for OSA. The independent odds ratio (OR) for hyperlipidaemia in relation to measures of OSA (ODI, apnoea-hypopnoea index, mean and lowest oxygen saturation) was determined by means of general linear model analysis with adjustment for important confounders such as age, BMI, comorbidities and study site. Results: Hyperlipidaemia prevalence increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Corresponding numbers in patients with diabetes were 8.5% and 41.5%, P < 0.001. Compared with ODI quartile I, patients in ODI quartiles II-IV had an adjusted OR (95% CI) of 1.33 (1.15–1.55), 1.37 (1.17–1.61) and 1.33 (1.12–1.58) (P < 0.001), respectively, for hyperlipidaemia. Obesity was defined as a significant risk factor for hyperlipidaemia. Subgroups of OSA patients with cardio-metabolic comorbidities demonstrated higher prevalence of HL. In addition, differences in hyperlipidaemia prevalence were reported in European geographical regions with the highest prevalence in Central Europe. Conclusion: Obstructive sleep apnoea, in particular intermittent hypoxia, was independently associated with the prevalence of hyperlipidaemia diagnosis.

Published
2019

24. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author

Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R. L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J. A., Tamisier R., Lombardi C., Marrone O., McNicholas W. T., Montserrat J. M., Parati G., Pataka A., Penzel T., Pepin J. L., Pretl M., Roisman G., Schiza S. E., Schulz R., Sliwinski P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R. L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J. A., Tamisier R., Lombardi C., Marrone O., McNicholas W. T., Montserrat J. M., Parati G., Pataka A., Penzel T., Pepin J. L., Pretl M., Roisman G., Schiza S. E., Schulz R., Sliwinski P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., and Vrints H.

Abstract

Purpose: The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods: Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results: The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m2), and ODI (15 vs. 32/h). Conclusion: High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms.

Published
2019

25. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author

Riha, Renata L., primary, Kotoulas, Serafeim – Chrysovalantis, additional, Pataka, Athanasia, additional, Kvamme, John Arthur, additional, Joppa, Pavol, additional, Hedner, Jan, additional, Anttalainen, U., additional, Barbé, F., additional, Bonsignore, M.R., additional, Basoglu, O., additional, Bielicki, P., additional, Bouloukaki, I., additional, Dogas, Z., additional, Dorkova, Z., additional, Escourrou, P., additional, Fietze, I., additional, Esquinas, C., additional, Grote, L., additional, Kent, B.D., additional, Lena, Lavie, additional, Lavie, P., additional, Levy, P., additional, Lombardi, C., additional, Marrone, O., additional, Masa, J.F., additional, McNicholas, W.T., additional, Montserrat, J.M., additional, Parati, G., additional, Penzel, T., additional, Pépin, J.L., additional, Plywaczewski, R., additional, Pretl, M., additional, Rodenstein, D., additional, Roisman, G., additional, Ryan, S., additional, Saaresranta, T., additional, Schiza, S.E., additional, Schulz, R., additional, Sliwinski, P., additional, Staats, R., additional, Steiropoulos, P., additional, Tasbakan, M.S., additional, Tkacova, R., additional, Varoneckas, G., additional, Verbraecken, J., additional, Vitols, A., additional, Vrints, H., additional, and Zielinski, J., additional

Published
2021
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26. Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study

Author

Marrone, O, Battaglia, S, Steiropoulos, P, Basoglu, O, Kvamme, J, Ryan, S, Pepin, J, Verbraecken, J, Grote, L, Hedner, J, Bonsignore, M, Anttalainen, U, Saaresranta, T, Barbé, F, Tasbakan, S, Bielicki, P, Kumor, M, Dumitrascu, R, Schulz, R, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Mcnicholas, W, Lévy, P, Pépin, J, Tamisier, R, Lavie, L, Lavie, P, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Rodenstein, D, Tkacova, R, Varoneckas, G, Vrints, H, Vitols, A., LOMBARDI, CAROLINA, PARATI, GIANFRANCO, ESADA Study Grp, Marrone, O., Battaglia, S., Steiropoulos, P., Basoglu, O., Kvamme, J., Ryan, S., Pepin, J., Verbraecken, J., Grote, L., Hedner, J., Bonsignore, M., Marrone, O, Battaglia, S, Steiropoulos, P, Basoglu, O, Kvamme, J, Ryan, S, Pepin, J, Verbraecken, J, Grote, L, Hedner, J, Bonsignore, M, Anttalainen, U, Saaresranta, T, Barbé, F, Tasbakan, S, Bielicki, P, Kumor, M, Dumitrascu, R, Schulz, R, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Mcnicholas, W, Lévy, P, Pépin, J, Tamisier, R, Lavie, L, Lavie, P, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Rodenstein, D, Tkacova, R, Varoneckas, G, Vrints, H, and Vitols, A

Subjects
Male, Comorbidity, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Risk Factors, Prevalence, obstructive sleep apnea, Aged, 80 and over, Sex Characteristics, Sleep Apnea, Obstructive, Medicine (all), Sleep apnea, General Medicine, Middle Aged, Europe, Hypertension, Cardiology, nephropathy, epidemiology, Female, Glomerular Filtration Rate, Cohort study, Adult, medicine.medical_specialty, Adolescent, Polysomnography, Cognitive Neuroscience, Renal function, Settore MED/10 - Malattie Dell'Apparato Respiratorio, ta3111, Nephropathy, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Obesity, Renal Insufficiency, Chronic, Aged, Heart Failure, hypoxia, business.industry, medicine.disease, Oxygen, Obstructive sleep apnea, Cross-Sectional Studies, 030228 respiratory system, Heart failure, Physical therapy, Human medicine, business, Body mass index, 030217 neurology & neurosurgery, Kidney disease
Abstract

The cross-sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate = 30) was found in 34% of subjects. The lowest nocturnal oxygen saturation was 81 +/- 10.2%. Chronic kidney disease prevalence in the whole sample was 8.7% or 6.1%, according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease-Epidemiology Collaboration equations, respectively. Subjects with lower estimated glomerular filtration rate were older, more obese, more often female, had worse obstructive sleep apnea and more co-morbidities (P < 0.001, each). With both equations, independent predictors of estimated glomerular filtration rate < 60 were: chronic heart failure; female gender; systemic hypertension; older age; higher body mass index; and worse lowest nocturnal oxygen saturation. It was concluded that in obstructive sleep apnea, chronic kidney disease is largely predicted by co-morbidities and anthropometric characteristics. In addition, severe nocturnal hypoxaemia, even for only a small part of the night, may play an important role as a risk factor for kidney dysfunction.

Published
2016
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27. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author

Gunduz, Canan, primary, Basoglu, Ozen K., additional, Kvamme, John Arthur, additional, Verbraecken, Johan, additional, Anttalainen, Ulla, additional, Marrone, Oreste, additional, Steiropoulos, Paschalis, additional, Roisman, Gabriel, additional, Joppa, Pavol, additional, Hein, Holger, additional, Trakada, Georgia, additional, Hedner, Jan, additional, Grote, Ludger, additional, Steiropoulos, P., additional, Verbraecken, J., additional, Petiet, E., additional, Trakada, G., additional, Montserrat, J.M., additional, Fietze, I., additional, Penzel, T., additional, Ondrej, L., additional, Rodenstein, D., additional, Masa, J.F., additional, Bouloukaki, I., additional, Schiza, S., additional, Kent, B., additional, McNicholas, W.T., additional, Ryan, S., additional, Riha, R.L., additional, Kvamme, J.A., additional, Hein, H., additional, Schulz, R., additional, Grote, L., additional, Hedner, J., additional, Zou, D., additional, Pépin, J.L., additional, Levy, P., additional, Bailly, S., additional, Lavie, L., additional, Lavie, P., additional, Basoglu, O.K., additional, Tasbakan, M.S., additional, Varoneckas, G., additional, Joppa, P., additional, Tkacova, R., additional, Staats, R., additional, Barbé, F., additional, Lombardi, C., additional, Parati, G., additional, Drummond, M., additional, van Zeller, M., additional, Bonsignore, M.R., additional, Marrone, O., additional, Petitjean, M., additional, Roisman, G., additional, Pretl, M., additional, Vitols, A., additional, Dogas, Z., additional, Galic, T., additional, Pataka, A., additional, Anttalainen, U., additional, Saaresranta, T., additional, Plywaczewski, R., additional, Sliwinski, P., additional, and Bielicki, P., additional

Published
2020
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28. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author

Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., and Vitols, A.

Abstract

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1,415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non-obese (body mass index <30 kg/m2) patients, positive airway pressure treatment was associated with an increased body mass index and waist circumference (0.4 [0.3–0.5] kg/m2 and 0.8 [0.4–1.2] cm, respectively, all p < 0.05), and weight gain was significantly associated with higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positive airway pressure treatment (−0.3 [−0.5 to −0.1] kg/m2, p < 0.05) mainly in patients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positive airway pressure therapy was not found to systematically change body mass index in the European Sleep Apnea Database cohort, but the response was heterogeneous. Our findings suggest that weight gain may be restricted to an obstructive sleep apnea phenotype without established obesity. Lifestyle intervention needs to be considered in both lean and obese patients with obstructive slee

Published
2018

29. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author

Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., and Vitols, A.

Abstract

Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.

Published
2018

30. Sleep apnoea management in Europe during the COVID-19 pandemic – Data from the European Sleep Apnoea Database (ESADA)

Author

Grote, L. McNicholas, W.T. Hedner, J. Anttalainen, U. Saaresranta, T. Basoglu, O.K. Gunduz, C. Tasbakan, S. Bouloukaki, I. Schiza, S.E. Bonsignore, M.R. Marrone, O. Petitjean, M. Roisman, G. Fietze, I. Laharnar, N. Penzel, T. Hedner, J. Zou, D. Grote, L. Kent, B.D. McNicholas, W.T. Ryan, S. Kvamme, J.A. Bailly, S. Pépin, J.-L. Tamisier, R. Lombardi, C. Parati, G. Pataka, A. Plywaczewski, R. Sliwinski, P. Pretl, M. Riha, R. Staats, R. Steiropoulos, P. Joppa, P. Verbraecken, J. Petiet, E. Trakada, G. Ludka, O. Bušková, J. Hein, H. Drummond, M. van Zeller, M. Dogas, Z. Galic, T. Gouveris, H. Mihaicuta, S. Randerath, W. Herkenrath, S. Fanfulla, F. Testelmans, D. ESADA collaborators

Published
2020

31. Impact of sleep apnea on the overall cardioembolic risk in patients with atrial fibrillation: a cross-sectional analysis of the ESADA cohort

Author

Pengo, M. F., Faini, A., Grote, L., Ludka, O., Joppa, P., Pataka, A., Đogaš, Zoran, Mihaicuta, S., Hein, H., Anttalainen, U., Ryan, S., Lombardi, C., and Parati, G.

Subjects
sleep apnea, atrial fibrillation, cardioembolic risk
Abstract

Objectives/Introduction: Atrial fibrillation (AF) is the most common supra-ventricular arrhythmia worldwide and is one of the causes of ischemic stroke. Obstructive sleep apnea (OSA) and AF often coexist and share several predisposing factors. In patients with AF, assessment of thromboembolic risk, and subsequent use of appropriate therapy is crucial for stroke prevention. The aim of the present study is to understand if the presence of OSA carries a significant additional cardioembolic risk to patients with AF. Methods: The ESADA Study prospectively collects data from unselected adult patients aged 18–80 years with suspected OSA referred European sleep centres. In the present study, patients with OSA and AF were included and the CHA2DS2-VASc score was calculated according to current guidelines. Based on ESC guidelines on AF, patients were stratified into 3 risk categories: low, moderate and high risk of cardio-embolic events. Results: Cross-sectional data of 14646 patients were included in the analysis. From the total sample, a cohort of 363 patients with AF was analysed. The distribution of CHADVASC score is shown in figure 1. ODI, but not AHI, was significantly increased in category 1 and ≥2 when compared to low cardioembolic risk (Chi-squared p-value

Published
2020

32. Effects of sleep apnea and kidney dysfunction on objective sleep quality in nondialyzed patients with chronic kidney disease: An ESADA study

Author

Marrone, O. Cibella, F. Roisman, G. Sliwinski, P. Joppa, P. Basoglu, O.K. Bouloukaki, I. Schiza, S. Pataka, A. Staats, R. Verbraecken, J. Hedner, J. Grote, L. Bonsignore, M.R. Anttalainen, U. Saaresranta, T. Bailly, S. Pépin, J.-L. Tamisier, R. Basoglu, O.K. Tasbakan, S. Bonsignore, M.R. Cibella, F. Bouloukaki, I. Schiza, S. Dogas, Z. Drummond, M. von Zeller, M. Escourrou, P. Roisman, G. Fietze, I. Penzel, T. Grote, L. Hedner, J. Zou, D. Gouveris, H. Joppa, P. Tkacova, R. Hein, H. Kent, B.D. McNicholas, W.T. Ryan, S. Kvamme, J.A. Lombardi, C. Parati, G. Ludka, O. Mihaicuta, S. Pataka, A. Plywaczewski, R. Sliwinski, P. Pretl, M. Riha, R. Staats, R. Steiropoulos, P. Trakada, G. Verbraecken, J. ESADA study group

Subjects
urologic and male genital diseases, female genital diseases and pregnancy complications
Abstract

Study Objectives: Patients with chronic kidney disease (CKD) often report poor sleep quality, but they commonly exhibit OSA. The aim of this study was to evaluate the influence of OSA severity and of estimated glomerular filtration rate impairment on objective sleep quality in nondialyzed patients with CKD, defined as an estimated glomerular filtration rate

Published
2020

33. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author

Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L, ESADA Study Group., ESADA Study Grp, Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, and Vitols, A

Subjects
Data Analysis, Male, Time Factors, Excessive daytime sleepiness, Weight Gain, excessive daytime sleepine, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Positive airway pressure, Medicine, Longitudinal Studies, Prospective Studies, obstructive sleep apnea, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Epworth Sleepiness Scale, Sleep apnea, General Medicine, Middle Aged, weight, central obesity, positive airway pressure, ESADA cohort, Europe, Obesity, Abdominal, Cardiology, Female, Waist Circumference, medicine.symptom, Adult, medicine.medical_specialty, Cognitive Neuroscience, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, Humans, Aged, business.industry, Body Weight, body weight, central obesity, excessive daytime sleepiness, obstructive sleep apnea, positive airway pressure, ta3121, medicine.disease, Obesity, respiratory tract diseases, Obstructive sleep apnea, 030228 respiratory system, Human medicine, business, Body mass index, Weight gain, 030217 neurology & neurosurgery
Abstract

The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non- obese (body mass index

Published
2018

35. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

Author

Pataka, Athanasia, Bonsignore, Maria R., Ryan, Silke, Riha, Renata L., Pepin, Jean-Louis, Schiza, Sofia, Basoglu, Ozen K., Sliwinski, Pawel, Ludka, Ondrej, Steiropoulos, Paschalis, Anttalainen, Ulla, McNicholas, Walter T., Hedner, Jan, Grote, Ludger, Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I., Penzel, T., Ludka, O., Rodenstein, D., Masa, J. F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Grote, L., Hedner, J., Pepin, J-L., Levy, P., Lavie, L., Lavie, P., Hein, H., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Safarik, P. J., Tkacova, R., Staats, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Bonsignore, M. R., Marrone, O., Escourrou, P., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Sliwinski, P., Plywaczewski, R., Bielicki, P., ESADA Study Grp, Pataka A., Bonsignore M.R., Ryan S., Riha R.L., Pepin J.-L., Schiza S., Basoglu O.K., Sliwinski P., Ludka O., Steiropoulos P., Anttalainen U., McNicholas W.T., Hedner J., Grote L., Aristotle University of Thessaloniki, Università degli studi di Palermo - University of Palermo, University College Dublin [Dublin] (UCD), Royal Infirmary of Edinburgh, Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), University of Crete [Heraklion] (UOC), Ege university, National Institute of Tuberculosis and Lung Diseases, St. Anne’s University Hospital [Brno], Democritus University of Thrace (DUTH), University of Turku, Sahlgrenska University Hospital [Gothenburg], University of Gothenburg (GU), ESADA study group: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, O Ludka, D Rodenstein, J F Masa, I Bouloukaki, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, L Grote, J Hedner, J L Pepin, P Levy, L Lavie, P Lavie, H Hein, O K Basoglu, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, R Staats, F Barbe, C Lombardi, G Parati, M Drummond, M van Zeller, M R Bonsignore, O Marrone, P Escourrou, G Roisman, M Pretl, A Vitols, Z Dogas, T Galic, A Pataka, U Anttalainen, T Saaresranta, P Sliwinski, R Plywaczewski, P Bielicki, and SALAS, Danielle

Subjects
Male, obesity, Letter, Databases, Factual, Download, [SDV]Life Sciences [q-bio], cigarette smoking, Polysomnography, cancer risk, disease burden, apnea hypopnea index, sleep disordered breathing, study design, 0302 clinical medicine, polysomnography, Risk Factors, Nothing, cancer diagnosis, Neoplasms, middle aged, gender, Prevalence, 030212 general & internal medicine, Sleep study, obstructive sleep apnea, Sleep Apnea, Obstructive, education.field_of_study, anthropometry, quantitative analysis, medicine.diagnostic_test, adult, risk assessment, clinical trial, cohort analysis, prostate cancer, pulse oximetry, [SDV] Life Sciences [q-bio], Europe, not available, comorbidity, aged, female, waist hip ratio, colon cancer, priority journal, risk factor, factual database, disease severity, cerebrovascular accident, Pulmonary and Respiratory Medicine, medicine.medical_specialty, alcohol consumption, intermittent hypoxia, Population, MEDLINE, lymphoma, Settore MED/10 - Malattie Dell'Apparato Respiratorio, malignant neoplasm, cancer growth, 03 medical and health sciences, melanoma, medicine, cancer, cross-sectional study, Humans, controlled study, human, education, Cancer prevalence, hypoxia, business.industry, statistical model, Conflict of interest, prediction, major clinical study, body mass, oxygen saturation, lung cancer, multicenter study, Cross-Sectional Studies, Logistic Models, age, 030228 respiratory system, disease severity assessment, Family medicine, oxygen desaturation index, head and neck cancer, Human medicine, business, neoplasm
Abstract

[No abstract available], ResMed Foundation; Philips; European Respiratory Society, ERS; Fondation Air Liquide, Conflict of interest: A. Pataka has nothing to disclose. M.R. Bonsignore has nothing to disclose. S. Ryan has nothing to disclose. R.L. Riha has nothing to disclose. J-L. Pepin reports grants and research funds from Air Liquide Foundation, Agiradom, AstraZeneca, Fisher and Paykel, Mutualia, Philips, Resmed and Vitalaire, personal fees from Agiradom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed and Sefam. S. Schiza has nothing to disclose. O.K. Basoglu has nothing to disclose. P. Sliwinski has nothing to disclose. O. Ludka has nothing to disclose. P. Steiropoulos has nothing to disclose. U. Anttalainen has nothing to disclose. W.T. McNicholas has nothing to disclose. J. Hedner reports grants from ResMed Foundation, Philips Respironics and the European Respiratory Society, for start-up and conduct of the study. L. Grote reports grants from Resmed Foundation and Respironics Foundation, during the conduct of the study; personal fees for lecturing from Resmed, Philips and Itamar, grants from Resmed, other (equipment) from Itamar, outside the submitted work; in addition, L. Grote has a patent for sleep apnoea treatment pending., Support statement: The ESADA network has received support from the European Union COST action B26 and is currently a Clinical Research Collaboration funded by the European Respiratory Society. Additionally, the ESADA study group has received unrestricted seeding grants from the ResMed and the Philips Respironics Foundation for the establishment of the database in 2007 and 2011. The ESADA has an ongoing collaboration with Bayer AG. Non-financial support was provided by the European Sleep Research Society and the European Respiratory Society for communication, meetings and data presentations for the ESADA collaborators.

Published
2019
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36. Clinical phenotypes and comorbidity in European sleep apnoea patients

Author

Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., Zielinski J., Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, ESADA Study Group, Ege Üniversitesi, ESADA Study Grp, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Saaresranta, T., Hedner, J., Bonsignore, M., Riha, R., Mcnicholas, W., Penzel, T., Anttalainen, U., Kvamme, J., Pretl, M., Sliwinski, P., Verbraecken, J., Grote, L., Barbé, F., Basoglu, B., Bielicki, P., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kumor, M., Kurki, S., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Marrone, O., Masa, J., Montserrat, J., Parati, G., Pataka, A., Pépin, J., Plywaczewski, R., Rodenstein, D., Roisman, G., Ryan, S., Schulz, R., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Vrints, H., and Zielinski, J.

Subjects
Male, Pulmonology, Physiology, Apnea, medicine.medical_treatment, lcsh:Medicine, Comorbidity, Polysomnography, Cardiovascular Medicine, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), THERAPY, Body Mass Index, 0302 clinical medicine, Risk Factors, Positive airway pressure, Medicine and Health Sciences, Insomnia, Medicine, Prospective Studies, Continuous positive airway pressure, lcsh:Science, Prospective cohort study, Clinical Neurophysiology, Aged, 80 and over, Hypersomnia, Multidisciplinary, medicine.diagnostic_test, Sleep apnea, Middle Aged, DEPRESSION, PREVALENCE, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Phenotype, Neurology, Physiological Parameters, Cardiovascular Diseases, CARDIOVASCULAR-DISEASE, Female, InformationSystems_MISCELLANEOUS, medicine.symptom, Engineering sciences. Technology, Hypopnea, INSOMNIA SYMPTOMS, Research Article, Adult, medicine.medical_specialty, Sleep Apnea, Adolescent, POSITIVE AIRWAY PRESSURE, Settore MED/10 - Malattie Dell'Apparato Respiratorio, White People, Young Adult, 03 medical and health sciences, Sleep Apnea Syndromes, DAYTIME, stomatognathic system, Comorbiditat, Diagnostic Medicine, Internal medicine, mental disorders, Humans, COMMON, Aged, HYPOPNEA, HYPERTENSION, business.industry, lcsh:R, Body Weight, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Biology and Life Sciences, ta3121, medicine.disease, Dyssomnias, respiratory tract diseases, nervous system diseases, ComputingMethodologies_PATTERNRECOGNITION, 030228 respiratory system, Physical therapy, lcsh:Q, Sleep Disorders, Physiological Processes, Sleep, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

PubMed ID: 27701416, Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established. Methods A prospective follow-up cohort of adult patients with OSA (apnoea-hypopnoea index (AHI) of ?5/h) from 17 European countries and Israel (n = 6,555) was divided into four clinical presentation phenotypes based on daytime symptoms labelled as excessive daytime sleepiness ("EDS") and nocturnal sleep problems other than OSA (labelled as "insomnia"): 1) EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/noninsomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results The EDS phenotype comprised 20.7%, the non-EDS/non-insomnia type 25.8%, the EDS/ insomnia type 23.7%, and the insomnia phenotype 29.8% of the entire cohort. Thus, clinical presentation phenotypes with insomnia symptoms were dominant with 53.5%, but only 5.6% had physician diagnosed insomnia. Cardiovascular comorbidity was less prevalent in the EDS and most common in the insomnia phenotype (48.9% vs. 56.8%, p

Published
2016
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37. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author

Dieltjens, M. Verbraecken, J.A. Hedner, J. Vanderveken, O.M. Steiropoulos, P. Kvamme, J.A. Saaresranta, T. Tkacova, R. Marrone, O. Dogas, Z. Schiza, S. Grote, L. Steiropoulos, P. Verbraecken, J. Petiet, E. Trakada, G. Montserrat, J.M. Fietze, I. Penzel, T. Ludka, O. Rodenstein, D. Masa, J.F. Bouloukaki, I. Schiza, S. Kent, B. McNicholas, W.T. Ryan, S. Riha, R.L. Kvamme, J.A. Schulz, R. Grote, L. Hedner, J. Zou, D. Pépin, J.L. Levy, P. Bailly, S. Lavie, L. Lavie, P. Hein, H. Basoglu, O.K. Tasbakan, M.S. Varoneckas, G. Joppa, P. Tkacova, R. Staats, R. Barbé, F. Lombardi, C. Parati, G. Drummond, M. van Zeller, M. Bonsignore, M.R. Marrone, O. Escourrou, P. Roisman, G. Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. Anttalainen, U. Saaresranta, T. Sliwinski, P. Plywaczewski, R. Bielicki, P. Zielinski, J. ESADA collaborators

Subjects
health services administration, mental disorders, humanities
Abstract

Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a subpopulation, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged ≤65 years, CGI scoring was generally better than in the elderly despite a similar degree of OSA (eg, ‘normal, not ill’ 24.2% vs 15.3%, p < 0.01, respectively). Independent predictors of CGI rating included age, BMI, AHI, ESS, cardio-metabolic comorbidities, and diagnosis based on polygraphy. CGI-improvement rating (Beta = −0.406, p < 0.01) was superior to sleep apnea severity or ESS-score (Beta = 0.052 and −0.021, p = 0.154 and 0.538 respectively) at baseline for prediction of good CPAP compliance at follow-up. Conclusions: CGI rating is confounded by gender, age class and the type of sleep diagnostic method. As OSA phenotypes differ, CGI may contribute as a clinical tool to reflect the significance of clinical disease. © 2018 Elsevier B.V.

Published
2019

38. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

Author

Pataka, Athanasia Bonsignore, Maria R. Ryan, Silke Riha, Renata L. Pepin, Jean-Louis Schiza, Sofia Basoglu, Ozen K. and Sliwinski, Pawel Ludka, Ondrej Steiropoulos, Paschalis and Anttalainen, Ulla McNicholas, Walter T. Hedner, Jan Grote, Ludger Steiropoulos, P. Verbraecken, J. Petiet, E. and Trakada, G. Montserrat, J. M. Fietze, I. Penzel, T. and Ludka, O. Rodenstein, D. Masa, J. F. Bouloukaki, I. and Schiza, S. Kent, B. McNicholas, W. T. Ryan, S. Riha, R. L. Kvamme, J. A. Schulz, R. Grote, L. Hedner, J. and Pepin, J-L. Levy, P. Lavie, L. Lavie, P. Hein, H. and Basoglu, O. K. Tasbakan, M. S. Varoneckas, G. Joppa, P. and Safarik, P. J. Tkacova, R. Staats, R. Barbe, F. and Lombardi, C. Parati, G. Drummond, M. van Zeller, M. and Bonsignore, M. R. Marrone, O. Escourrou, P. Roisman, G. and Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. and Anttalainen, U. Saaresranta, T. Sliwinski, P. Plywaczewski, R. Bielicki, P. ESADA Study Grp

Published
2019

39. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author

Dieltjens, Marijke, primary, Verbraecken, Johan A., additional, Hedner, Jan, additional, Vanderveken, Olivier M., additional, Steiropoulos, Paschalis, additional, Kvamme, John A., additional, Saaresranta, Tarja, additional, Tkacova, Ruzena, additional, Marrone, Oreste, additional, Dogas, Zoran, additional, Schiza, Sofia, additional, Grote, Ludger, additional, Steiropoulos, P., additional, Verbraecken, J., additional, Petiet, E., additional, Trakada, Georgia, additional, Montserrat, J.M., additional, Fietze, I., additional, Penzel, T., additional, Ludka, Ondrej, additional, Rodenstein, Daniel, additional, Masa, J.F., additional, Bouloukaki, I., additional, Schiza, S., additional, Kent, B., additional, McNicholas, W.T., additional, Ryan, S., additional, Riha, R.L., additional, Kvamme, J.A., additional, Schulz, R., additional, Grote, L., additional, Hedner, J., additional, Zou, Ding, additional, Pépin, J.L., additional, Levy, P., additional, Bailly, Sebastian, additional, Lavie, Lena, additional, Lavie, Peretz, additional, Hein, H., additional, Basoglu, O.K., additional, Tasbakan, M.S., additional, Varoneckas, G., additional, Joppa, P., additional, Tkacova, Ra, additional, Staats, R., additional, Barbé, F., additional, Lombardi, C., additional, Parati, G., additional, Drummond, Marta, additional, van Zeller, Mafalda, additional, Bonsignore, M.R., additional, Marrone, O., additional, Escourrou, P., additional, Roisman, G., additional, Pretl, M., additional, Vitols, A., additional, Dogas, Z., additional, Galic, T., additional, Pataka, A., additional, Anttalainen, U., additional, Saaresranta, T., additional, Sliwinski, P., additional, Plywaczewski, R., additional, Bielicki, P., additional, and Zielinski, Jan, additional

Published
2019
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40. Clinical phenotypes and comorbidity in European sleep apnoea patients

Author

Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., Zielinski J., Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., and Zielinski J.

Abstract

Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established. Methods A prospective follow-up cohort of adult patients with OSA (apnoea-hypopnoea index (AHI) of ≥5/h) from 17 European countries and Israel (n = 6,555) was divided into four clinical presentation phenotypes based on daytime symptoms labelled as excessive daytime sleepiness ("EDS") and nocturnal sleep problems other than OSA (labelled as "insomnia"): 1) EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/noninsomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results The EDS phenotype comprised 20.7%, the non-EDS/non-insomnia type 25.8%, the EDS/ insomnia type 23.7%, and the insomnia phenotype 29.8% of the entire cohort. Thus, clinical presentation phenotypes with insomnia symptoms were dominant with 53.5%, but only 5.6% had physician diagnosed insomnia. Cardiovascular comorbidity was less prevalent in the EDS and most common in the insomnia phenotype (48.9% vs. 56.8%, p<0.001) despite more severe OSA in the EDS group (AHI 35.0±25.5/h vs. 27.9±22.5/h, p<0.001, respectively). Psychiatric comorbidity was associated with insomnia like OSA phenotypes independent of age, gender and body mass index (HR 1.5 (1.188-1.905), p<0.001). The EDS phenotype tended to associate with higher CPAP usage (22.7 min/d, p = 0.069) when controlled for age, gender, BMI and sleep apnoea severity. Conclusions Phenotypes with insomnia symptoms comprised more than half of OSA patients and were more frequently linked with comorbidity than those with EDS, despite less severe OSA. CPAP usage was slightly higher in phenotypes with EDS.

Published
2016

41. Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort

Author

Bonsignore, M, Pepin, J, Anttalainen, U, Schiza, S, Basoglu, O, Pataka, A, Steiropoulos, P, Dogas, Z, Grote, L, Hedner, J, Mcnicholas, W, Marrone, O, Barbé, F, Bielicki, P, Bouloukaki, I, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kent, B, Kumor, M, Kurki, S, Kvamme, J, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Masa, J, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schulz, R, Sliwinski, P, Staats, R, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Bonsignore, Maria R., Pepin, Jean-Louis, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschalis, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B. D., Kumor, M., Kurki, S., Kvamme, J. A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J. F., Montserrat, J. M., Parati, G., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., Zielinski, J., Bonsignore, M, Pepin, J, Anttalainen, U, Schiza, S, Basoglu, O, Pataka, A, Steiropoulos, P, Dogas, Z, Grote, L, Hedner, J, Mcnicholas, W, Marrone, O, Barbé, F, Bielicki, P, Bouloukaki, I, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kent, B, Kumor, M, Kurki, S, Kvamme, J, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Masa, J, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schulz, R, Sliwinski, P, Staats, R, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Bonsignore, Maria R., Pepin, Jean-Louis, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschalis, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B. D., Kumor, M., Kurki, S., Kvamme, J. A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J. F., Montserrat, J. M., Parati, G., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., and Zielinski, J.

Abstract

Obstructive sleep apnea (OSA) and asthma are often associated and several studies suggest a bidirectional relationship between asthma and OSA. This study analyzed the characteristics of patients with suspected OSA from the European Sleep Apnea Database according to presence/absence of physician-diagnosed asthma. Cross-sectional data in 16,236 patients (29.1% female) referred for suspected OSA were analyzed according to occurrence of physician-diagnosed asthma for anthropometrics, OSA severity and sleepiness. Sleep structure was assessed in patients studied by polysomnography (i.e. 48% of the sample). The prevalence of physician-diagnosed asthma in the entire cohort was 4.8% (7.9% in women, 3.7% in men, p < 0.0001), and decreased from subjects without OSA to patients with mild–moderate and severe OSA (p = 0.02). Obesity was highly prevalent in asthmatic women, whereas BMI distribution was similar in men with and without physician-diagnosed asthma. Distribution of OSA severity was similar in patients with and without physician-diagnosed asthma, and unaffected by treatment for asthma or gastroesophageal reflux. Asthma was associated with poor sleep quality and sleepiness. Physician-diagnosed asthma was less common in a sleep clinic population than expected from the results of studies in the general population. Obesity appears as the major factor raising suspicion of OSA in asthmatic women, whereas complaints of poor sleep quality were the likely reason for referral in asthmatic men.

Published
2018

42. Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA

Author

Marrone, O, Cibella, F, Pépin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Mcnicholas, W, Hedner, J, Bonsignore, M, Anttalainen, U, Barbè, F, Tasbakan, S, Bielicki, P, Kumor, M, Bouloukaki, I, Schiza, S, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Ryan, S, Lévy, P, Tamisier, R, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Tkacova, R, Varoneckas, G, Pépin, JL, Kvamme, JA, Basoglu, OK, McNicholas, WT, Bonsignore, MR, Kent, BD, Masa, JF, Montserrat, JM, Marrone, O, Cibella, F, Pépin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Mcnicholas, W, Hedner, J, Bonsignore, M, Anttalainen, U, Barbè, F, Tasbakan, S, Bielicki, P, Kumor, M, Bouloukaki, I, Schiza, S, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Ryan, S, Lévy, P, Tamisier, R, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Tkacova, R, Varoneckas, G, Pépin, JL, Kvamme, JA, Basoglu, OK, McNicholas, WT, Bonsignore, MR, Kent, BD, Masa, JF, and Montserrat, JM

Abstract

Background: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. Methods: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 144), patients receiving fixed CPAP (fCPAP) (n = 1,178), and patients on autoadjusting CPAP (APAP) (n = 485). Results: In the whole sample, eGFR decreased over time. The rate of eGFR decline was significantly higher in the subgroup with eGFR above median (91.42 mL/min/1.73 m 2 ) at baseline (P <.0001 for effect of baseline eGFR). This decline was attenuated or absent (P <.0001 for effect of treatment) in the subgroup of patients with OSA treated by using fCPAP. A follow-up duration exceeding the median (541 days) was associated with eGFR decline in the untreated and APAP groups but not in the fCPAP group (P <.0001 by two-way ANOVA for interaction between treatment and follow-up length). In multiple regression analysis, eGFR decline was accentuated by advanced age, female sex, cardiac failure, higher baseline eGFR, and longer follow-up duration, whereas there was a protective effect of fCPAP. Conclusions: fCPAP but not APAP may prevent eGFR decline in OSA.

Published
2018

43. Diabetes mellitus prevalence and control in sleep-disordered breathing: The European Sleep Apnea Cohort (ESADA) study

Author

Kent, B, Grote, L, Ryan, S, Pépin, J, Bonsignore, M, Tkacova, R, Saaresranta, T, Verbraecken, J, Lévy, P, Hedner, J, McNicholas, W, Anttalainen, U, Barbe, F, Basoglu, O, Bielicki, P, Escourrou, P, Esquinas, C, Fietze, I, Hayes, L, Kumor, M, Kvamme, J, Lavie, L, Lavie, P, Marrone, O, Masa, J, Montserrat, J, Pataka, A, Penzel, T, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H., LOMBARDI, CAROLINA, PARATI, GIANFRANCO, Kent, B, Grote, L, Ryan, S, Pépin, J, Bonsignore, M, Tkacova, R, Saaresranta, T, Verbraecken, J, Lévy, P, Hedner, J, Mcnicholas, W, Anttalainen, U, Barbe, F, Basoglu, O, Bielicki, P, Escourrou, P, Esquinas, C, Fietze, I, Hayes, L, Kumor, M, Kvamme, J, Lavie, L, Lavie, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Kent, BD, Ryan, S, Pepin, JL, Bonsignore, MR, McNicholas, WT, and European Sleep Apnea Database collaborators

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Adolescent, Polysomnography, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Critical Care and Intensive Care Medicine, Severity of Illness Index, Regression Analysi, Cohort Studies, intermittent hypoxia, insulin resistance, HbA1C, Young Adult, Sleep Apnea Syndromes, Sleep Apnea Syndrome, Risk Factors, Prevalence, Humans, Prospective Studies, Israel, Aged, Glycated Hemoglobin, Aged, 80 and over, Cross-Sectional Studie, Hemoglobin A, Glycosylated, Risk Factor, Middle Aged, Europe, Prospective Studie, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Regression Analysis, Female, Cohort Studie, Cardiology and Cardiovascular Medicine, Human
Abstract

BACKGROUND: OSA is associated with an increased risk of cardiovascular morbidity. A driver of this is metabolic dysfunction and in particular type 2 diabetes mellitus (T2DM). Prior studies identifying a link between OSA and T2DM have excluded subjects with undiagnosed T2DM, and there is a lack of population-level data on the interaction between OSA and glycemic control among patients with diabetes. We assessed the relationship between OSA severity and T2DM prevalence and control in a large multinational population.METHODS: We performed a cross-sectional analysis of 6,616 participants in the European Sleep Apnea Cohort (ESADA) study, using multivariate regression analysis to assess T2DM prevalence according to OSA severity, as measured by the oxyhemoglobin desaturation index. Patients with diabetes were identified by previous history and medication prescription, and by screening for undiagnosed diabetes with glycosylated hemoglobin (HbA1c) measurement. The relationship of OSA severity with glycemic control was assessed in diabetic subjects.RESULTS: T2DM prevalence increased with OSA severity, from 6.6% in subjects without OSA to 28.9% in those with severe OSA. Despite adjustment for obesity and other confounding factors, in comparison with subjects free of OSA, patients with mild, moderate, or severe disease had an OR (95% CI) of 1.33 (1.04-1.72), 1.73 (1.33-2.25), and 1.87 (1.45-2.42) ( P < .001), respectively, for prevalent T2DM. Diabetic subjects with more severe OSA had worse glycemic control, with adjusted mean HbA1c levels 0.72% higher in patients with severe OSA than in those without sleep-disordered breathing (analysis of covariance, P < .001).CONCLUSIONS: Increasing OSA severity is associated with increased likelihood of concomitant T2DM and worse diabetic control in patients with T2DM.

Published
2014

44. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author

Carolina Lombardi, J. Verbraecken, Gabriel Roisman, Martin Pretl, Ludger Grote, Zoran Dogas, Pierre Escourrou, Patrick Levy, Pawel Sliwinski, Walter T. McNicholas, Tarja Saaresranta, Renata L. Riha, Daniel Rodenstein, Peretz Lavie, Cristina Esquinas, Jan Hedner, Athanasia Pataka, H. Vrints, A. Vitols, G. Parati, Giedrius Varoneckas, Serafeim Chrysovalantis Kotoulas, Ingo Fietze, R Pływaczewski, Oreste Marrone, Silke Ryan, Rainer Schulz, Ozen K. Basoglu, Jan Zieliński, Richard Staats, Ružena Tkáčová, Paschalis Steiropoulos, J.M. Montserrat, Piotr Bielicki, J.L. Pépin, Thomas Penzel, Lavie Lena, Juan F. Masa, Zuzana Dorkova, Pavol Joppa, Marisa Bonsignore, Mehmet Sezai Taşbakan, Ulla Anttalainen, John A. Kvamme, I Bouloukaki, Ferran Barbé, Brian D. Kent, Sofia Schiza, Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, SALAS, Danielle, University of Edinburgh, General Hospital of Thessaloniki George Papanikolaou, Førde Central Hospital [Førde, Norway] (FCH), Pavol Jozef Šafárik University, ESADA collaborators: U Anttalainen, F Barbé, M R Bonsignore, O Basoglu , P Bielicki, I Bouloukaki, Z Dogas, Z Dorkova, P Escourrou, I Fietze, C Esquinas, L Grote, B D Kent, Lavie Lena, P Lavie, P Levy, C Lombardi, O Marrone, J F Masa, W T McNicholas, J M Montserrat, G Parati, T Penzel, J L Pépin, R Plywaczewski, M Pretl, D Rodenstein, G Roisman, S Ryan, T Saaresranta, S E Schiza, R Schulz, P Sliwinski, R Staats, P Steiropoulos, M S Tasbakan, R Tkacova, G Varoneckas, J Verbraecken, A Vitols, H Vrints, J Zielinski, Riha R.L., Kotoulas S.-.C., Pataka A., Kvamme J.A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M.R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B.D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J.F., McNicholas W.T., Montserrat J.M., Parati G., Penzel T., Pepin J.L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S.E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M.S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., and Zielinski J.

Subjects
Adult, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], ESADA, Lymphoid tissue overgrowth, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Sleep apnoea, 0302 clinical medicine, medicine, Humans, Mass index, Respiratory system, Tonsillectomy, Sleep Apnea, Obstructive, Adult patients, business.industry, Sleep apnea, General Medicine, medicine.disease, Sleep in non-human animals, respiratory tract diseases, [SDV] Life Sciences [q-bio], Europe, 030228 respiratory system, Diabetes Mellitus, Type 2, Lower prevalence, Airway, business, Sleep, 030217 neurology & neurosurgery
Abstract

Background: The impact of removing the upper airway lymphoid tissue and in particular, tonsillectomy, in adults with OSA has not been demonstrated in large populations. Aims: To compare the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between patients with OSA who had undergone previous tonsillectomy and those who had not. Methods: The 19,711 participants in this study came from the European sleep apnea database (ESADA) which comprises data from unselected adult patients aged 18–80 years with a history of symptoms suggestive of OSA referred to sleep centers throughout Europe. Results: There were no differences between the two groups in terms of sex ratio and age (146 patients with previous tonsillectomy vs. 19565 patients without). Patients who had undergone tonsillectomy had a lower body mass index (29.3 ± 5.2 kg/m2 vs 32.2 ± 6.6 kg/m2, p < 0.001), lower subjective sleep latency (17.1 ± 17.8 min vs 25.5 ± 30.4 min, p = 0.001), lower ODI (15.7 ± 18.3 events/hour vs 30.7 ± 26.1 events/hour, p < 0.001), and SpO2, European Respiratory Society, ERS, The ESADA network has previously received support from the European Union COST action B26 and the European Respiratory Society. We gratefully acknowledge unrestricted seeding grants from ResMed Inc and Philips Respironics Inc. for establishment of the organisation and the database. Excellent technical assistance in terms of centre monitoring and database maintenance was provided by Ann-Christin Lundquist, RN and Jeanette Norum, RN.

Published
2021
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45. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea : data from the European Sleep Apnea Database (ESADA)

Author

Patrick Levy, Tarja Saaresranta, Renata L. Riha, G. Roisman, Mehmet Sezai Taşbakan, Ulla Anttalainen, Holger Hein, Sébastien Bailly, H. Hein, J.A. Kvamme, F. Barbé, Ding Zou, Silke Ryan, Johan Verbraecken, Pavol Joppa, Paschalis Steiropoulos, Jan Hedner, M. Petitjean, L. Ondrej, P. Steiropoulos, Martin Pretl, Walter T. McNicholas, Canan Gunduz, Piotr Bielicki, Thomas Penzel, E. Petiet, Ludger Grote, G. Varoneckas, P. Sliwinski, J. Verbraecken, O.K. Basoglu, A. Vitols, R. Staats, T. Galic, Izolde Bouloukaki, Athanasia Pataka, M. Drummond, Daniel Rodenstein, Gabriel Roisman, R. Plywaczewski, O. Marrone, Gianfranco Parati, Peretz Lavie, M. van Zeller, Lena Lavie, Carolina Lombardi, Zoran Dogas, J.M. Montserrat, Oreste Marrone, Sofia Schiza, J.F. Masa, R. Tkacova, Georgia Trakada, Marisa Bonsignore, Ozen K. Basoglu, P. Joppa, Rainer Schulz, John A. Kvamme, J.L. Pépin, G. Trakada, Brian D. Kent, Ingo Fietze, U. Anttalainen, European Sleep Apnea Database, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Gunduz C., Basoglu O.K., Kvamme J.A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J.M., Fietze I., Penzel T., Ondrej L., Rodenstein D., Masa J.F., Bouloukaki I., Schiza S., Kent B., McNicholas W.T., Ryan S., Riha R.L., Schulz R., Zou D., Pepin J.L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M.S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M.R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., Bielicki P., Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, and Ege Üniversitesi

Subjects
cardiovascular risk, Adult, Male, medicine.medical_specialty, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Positive airway pressure, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Cardiovascular risk, Cholesterol, Hypoxia, Sleep apnea, Humans, positive airway pressure, Prospective Studies, Risk factor, Prospective cohort study, Hypoxia, Aged, Sleep Apnea, Obstructive, Framingham Risk Score, Continuous Positive Airway Pressure, business.industry, hypoxia, Sleep apnea, cholesterol, General Medicine, Middle Aged, medicine.disease, sleep apnea, Cardiovascular risk, Obstructive sleep apnea, Cholesterol, 030228 respiratory system, Patient Compliance, Female, Human medicine, business, Body mass index, 030217 neurology & neurosurgery, Dyslipidemia
Abstract

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies. © 2020 Elsevier B.V., ResMed Foundation European Respiratory Society, ERS European Respiratory Society, ERS European Respiratory Society, ERS, The ESADA network has received support from the European Union COST action B26 and the European Respiratory Society (ERS) funded Clinical Research Collaboration (CRC). Unrestricted seeding grants from the ResMed Foundation and the Philips Respironics Foundation for establishment of the database in 2007 and 2011 are gratefully acknowledged. The ESADA network has a scientific collaboration with Bayer AG., Nonfinancial support was provided by the European Sleep Research Society (ESRS) and the European Respiratory Society (ERS) in terms of logistics for communication, meetings and data presentations for the ESADA collaborators., Dr. Verbraecken reports grants and personal fees from ResMed, Bioprojet, Jazz Pharmaceutics; personal fees from Philips, Sanofi, Agfa-Gevaert, grants from AirLiquide; personal fees from Springer, Westfalen Medical, SomnoMed, Vivisol, Total Care, Medidis, Fisher & Paykel, Wave Medical, OSG, Mediq Tefa, NightBalance, Heinen & Löwenstein, AstraZen, Accuramed, Bekaert Deslee Academy and UCB Pharma, outside the submitted work. Dr. Hedner reports grants from ResMed, Philips Respironics, and the European Respiratory Society all related to maintenance of database on behalf of the ESADA group during the conduct of the study. Dr. Grote reports grants from Bayer, Resmed, Respironics/Philips, and from the European Respiratory Society during the conduct of the study; non-financial support and other from Itamar Medical, Resmed, Philips, and Astra Zeneca, outside the submitted work. In addition, Dr. Grote has a patent on sleep apnea therapy licensed. The remaining co-authors have no conflict of interest to declare.

Published
2020
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46. Impact of Sleep Apnea on Cardioembolic Risk in Patients With Atrial Fibrillation: Data From the ESADA Cohort

Author

Martino F. Pengo, Ondrej Ludka, Pavol Joppa, Athanasia Pataka, Ulla Anttalainen, Stefan Mihaicuta, Gianfranco Parati, Carolina Lombardi, Zoran Dogas, Andrea Faini, Silke Ryan, Holger Hein, Ludger Grote, Pengo, M, Faini, A, Grote, L, Ludka, O, Joppa, P, Pataka, A, Dogas, Z, Mihaicuta, S, Hein, H, Anttalainen, U, Ryan, S, Lombardi, C, and Parati, G

Subjects
Male, medicine.medical_specialty, Databases, Factual, Heart Diseases, Embolism, 030204 cardiovascular system & hematology, Risk Assessment, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Humans, Risk factor, Hypoxia, Stroke, Aged, Advanced and Specialized Nursing, Aged, 80 and over, Sleep Apnea, Obstructive, business.industry, Sleep apnea, Atrial fibrillation, Hypoxia (medical), Middle Aged, medicine.disease, atrial fibrillation, embolism, hypoxia, risk factor, sleep apnea, Obstructive sleep apnea, Oxygen, 030228 respiratory system, Cohort, Cardiology, Female, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Background and Purpose: An accurate determination of the cardioembolic risk in patients with atrial fibrillation (AF) is crucial to prevent consequences like stroke. Obstructive sleep apnea (OSA) is a known risk factor for both AF and stroke. We aim to explore a possible association between OSA and an increased cardioembolic risk in patients with AF. Methods: We assessed data from the ESADA (European Sleep Apnea Database) cohort where patients with known AF and OSA were included. Parameters of OSA severity and related hypoxia like lowest Sp o 2 and 4% oxygen desaturation index were analyzed. Patients were stratified according to their cardioembolic risk estimated with the CHA 2 DS 2 -VASc score. Results: From the initial cohort of 14 646 patients, a final set of 363 patients were included in the analysis. Indices of hypoxia during sleep were associated with increased CHA 2 DS 2 -VASc score (4% oxygen desaturation index 17.9 versus 29.6 versus 30.5 events/hour and the lowest Sp o 2 81.2 versus 77.8 versus 77.5% for low, moderate, and high cardioembolic risk, respectively, P Conclusions: These results support the potential role of OSA-related hypoxia in the risk for cardioembolic complications such as stroke in patients with AF.

Published
2020

47. Use of the Clinical Global Impression scale in sleep apnea patients - Results from the ESADA database

Author

Marijke Dieltjens, Johan A. Verbraecken, Jan Hedner, Olivier M. Vanderveken, Paschalis Steiropoulos, John A. Kvamme, Tarja Saaresranta, Ruzena Tkacova, Oreste Marrone, Zoran Dogas, Sofia Schiza, Ludger Grote, P. Steiropoulos, J. Verbraecken, E. Petiet, Georgia Trakada, J.M. Montserrat, I. Fietze, T. Penzel, Ondrej Ludka, Daniel Rodenstein, J.F. Masa, I. Bouloukaki, S. Schiza, B. Kent, W.T. McNicholas, S. Ryan, R.L. Riha, J.A. Kvamme, R. Schulz, L. Grote, J. Hedner, Ding Zou, J.L. Pépin, P. Levy, Sebastian Bailly, Lena Lavie, Peretz Lavie, H. Hein, O.K. Basoglu, M.S. Tasbakan, G. Varoneckas, P. Joppa, Ra Tkacova, R. Staats, F. Barbé, C. Lombardi, G. Parati, Marta Drummond, Mafalda van Zeller, M.R. Bonsignore, O. Marrone, P. Escourrou, G. Roisman, M. Pretl, A. Vitols, Z. Dogas, T. Galic, A. Pataka, U. Anttalainen, T. Saaresranta, P. Sliwinski, R. Plywaczewski, P. Bielicki, Jan Zielinski, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, and ESADA Collaborators

Subjects
Adult, Male, Databases, Factual, Polysomnography, Disease, Comorbidity, computer.software_genre, Severity of Illness Index, Comorbidities, 03 medical and health sciences, 0302 clinical medicine, Age, health services administration, mental disorders, Diagnosis, medicine, Humans, Prospective Studies, Disease severity, Aged, Sleep Apnea, Obstructive, Database, medicine.diagnostic_test, business.industry, Epworth Sleepiness Scale, Sleep apnea, Apnea, Gender, General Medicine, Anthropometry, Middle Aged, medicine.disease, ta3124, humanities, respiratory tract diseases, Obstructive sleep apnea, 030228 respiratory system, Clinical Global Impression, Female, Human medicine, Comorbiditie, medicine.symptom, business, computer, 030217 neurology & neurosurgery, Diagnosi
Abstract

Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a sub-population, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged

Published
2019

48. Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort

Author

Bonsignore, Maria R., Pepin, Jean-Louis, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschalis, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B. D., Kumor, M., Kurki, S., Kvamme, J. A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J. F., Montserrat, J. M., Parati, G., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., Zielinski, J., Bonsignore, M, Pepin, J, Anttalainen, U, Schiza, S, Basoglu, O, Pataka, A, Steiropoulos, P, Dogas, Z, Grote, L, Hedner, J, Mcnicholas, W, Marrone, O, Barbé, F, Bielicki, P, Bouloukaki, I, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kent, B, Kumor, M, Kurki, S, Kvamme, J, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Masa, J, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schulz, R, Sliwinski, P, Staats, R, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Bonsignore, Maria R., Pepin, Jean-Loui, Anttalainen, Ulla, Schiza, Sophia E., Basoglu, Ozen K., Pataka, Athanasia, Steiropoulos, Paschali, Dogas, Zoran, Grote, Ludger, Hedner, Jan, McNicholas, Walter T., Marrone, Oreste, Barbé, F., Bielicki, P., Bouloukaki, I., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kent, B.D., Kumor, M., Kurki, S., Kvamme, J.A., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Masa, J.F., Montserrat, J.M., Parati, G., Penzel, T., Pépin, J.L., Plywaczewski, R., Pretl, M., Riha, R.L., Rodenstein, D., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Staats, R., Tasbakan, M.S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vitols, A., Vrints, H., and Zielinski, J.

Subjects
Adult, Male, obesity, medicine.medical_specialty, Cognitive Neuroscience, Polysomnography, Population, Settore MED/10 - Malattie Dell'Apparato Respiratorio, ta3111, Cohort Studies, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, obstructive sleep apnea, asthma, ESADA cohort, Internal medicine, Epidemiology, gender, Medicine, Humans, Prospective Studies, education, Physician's Role, Asthma, Aged, education.field_of_study, Sleep Apnea, Obstructive, medicine.diagnostic_test, business.industry, ta1184, sleep-disordered breathing, Sleep apnea, General Medicine, Middle Aged, medicine.disease, Obesity, respiratory tract diseases, Obstructive sleep apnea, Europe, Cross-Sectional Studies, 030228 respiratory system, Cohort, epidemiology, Female, Self Report, business, 030217 neurology & neurosurgery
Abstract

Obstructive sleep apnea (OSA) and asthma are often associated and several studies suggest a bidirectional relationship between asthma and OSA. This study analyzed the characteristics of patients with suspected OSA from the European Sleep Apnea Database according to presence/absence of physician-diagnosed asthma. Cross-sectional data in 16,236 patients (29.1% female) referred for suspected OSA were analyzed according to occurrence of physician-diagnosed asthma for anthropometrics, OSA severity and sleepiness. Sleep structure was assessed in patients studied by polysomnography (i.e. 48% of the sample). The prevalence of physician-diagnosed asthma in the entire cohort was 4.8% (7.9% in women, 3.7% in men, p&nbsp

Published
2018

49. Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA

Author

Oreste Marrone, Fabio Cibella, Jean-Louis Pépin, Ludger Grote, Johan Verbraecken, Tarja Saaresranta, John A. Kvamme, Ozen K. Basoglu, Carolina Lombardi, Walter T. McNicholas, Jan Hedner, Maria R. Bonsignore, Ulla Anttalainen, Ferran Barbè, Sezai Tasbakan, Piotr Bielicki, Marta Kumor, Izolde Bouloukaki, Sophia Schiza, Pierre Escourrou, Gabriel Roisman, Ingo Fietze, Thomas Penzel, Brian D. Kent, Silke Ryan, Patrick Lévy, Renaud Tamisier, Gianfranco Parati, Juan Fernando Masa, Josep M. Montserrat, Athanasia Pataka, Robert Plywaczewski, Pawel Sliwinski, Martin Pretl, Renata Riha, Richard Staats, Paschalis Steiropoulos, Ruzena Tkacova, Giedvar Varoneckas, Marrone, Oreste, Cibella, Fabio, Pépin, Jean-Loui, Grote, Ludger, Verbraecken, Johan, Saaresranta, Tarja, Kvamme, John A., Basoglu, Ozen K., Lombardi, Carolina, McNicholas, Walter T., Hedner, Jan, Bonsignore, Maria R., Anttalainen, Ulla, Barbè, Ferran, Tasbakan, Sezai, Bielicki, Piotr, Kumor, Marta, Bouloukaki, Izolde, Schiza, Sophia, Escourrou, Pierre, Roisman, Gabriel, Fietze, Ingo, Penzel, Thoma, Kent, Brian D., Ryan, Silke, Lévy, Patrick, Tamisier, Renaud, Parati, Gianfranco, Masa, Juan Fernando, Montserrat, Josep M., Pataka, Athanasia, Plywaczewski, Robert, Sliwinski, Pawel, Pretl, Martin, Riha, Renata, Staats, Richard, Steiropoulos, Paschali, Tkacova, Ruzena, Varoneckas, Giedvar, Marrone, O, Cibella, F, Pépin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Mcnicholas, W, Hedner, J, Bonsignore, M, Anttalainen, U, Barbè, F, Tasbakan, S, Bielicki, P, Kumor, M, Bouloukaki, I, Schiza, S, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Ryan, S, Lévy, P, Tamisier, R, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Tkacova, R, Varoneckas, G, and ESADA Network

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Urology, Renal function, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Egfr decline, Critical Care and Intensive Care Medicine, OSA, 03 medical and health sciences, 0302 clinical medicine, Positive airway pressure, medicine, automatic CPAP, In patient, Kidney, glomerular filtration rate, therapy, business.industry, Sleep apnea, fixed CPAP, ta3121, medicine.disease, respiratory tract diseases, Large sample, medicine.anatomical_structure, 030228 respiratory system, Cohort, Human medicine, business, Cardiology and Cardiovascular Medicine, 030217 neurology & neurosurgery
Abstract

BACKGROUND: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. METHODS: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 144), patients receiving fixed CPAP (fCPAP) (n = 1,178), and patients on autoadjusting CPAP (APAP) (n = 485). RESULTS: In the whole sample, eGFR decreased over time. The rate of eGFR decline was significantly higher in the subgroup with eGFR above median (91.42 mL/min/1.73 m(2)) at baseline (P < .0001 for effect of baseline eGFR). This decline was attenuated or absent (P < .0001 for effect of treatment) in the subgroup of patients with OSA treated by using fCPAP. A follow-up duration exceeding the median (541 days) was associated with eGFR decline in the untreated and APAP groups but not in the fCPAP group (P < .0001 by two-way ANOVA for interaction between treatment and follow-up length). In multiple regression analysis, eGFR decline was accentuated by advanced age, female sex, cardiac failure, higher baseline eGFR, and longer follow-up duration, whereas there was a protective effect of fCPAP. CONCLUSIONS: fCPAP but not APAP may prevent eGFR decline in OSA.

Published
2018

50. Factors predictive of extensive use of CPAP treatment in obstructive sleep apnoea.

Author

Doghman F, Ballo H, Anttalainen U, and Saaresranta T

Subjects
Humans, Male, Middle Aged, Female, Aged, Retrospective Studies, Age Factors, Body Mass Index, Sleep Apnea, Obstructive therapy, Continuous Positive Airway Pressure
Abstract

Aim: In patients with obstructive sleep apnoea (OSA), the benefits of continuous positive airway pressure (CPAP) therapy are increased for every additional hour of daily CPAP usage. However, the data of predictors of extensive usage is scarce, if any. Therefore, we evaluated potential predictors affecting extensive treatment usage., Methods: In this retrospective study, we compiled an institutional cohort of consecutive patients diagnosed with who started CPAP therapy 1999-2022 and were included in a wireless telemonitoring system in May 2022 (N = 14,394). Patients using CPAP device ≥ 9 h/d were stratified into a younger (< 65 years; N = 124) and an older group (≥ 65 years; N = 131)., Results: We found 255 patients (male 61%) eligible for our study, with a median age of 65 (interquartile range, IQR 55-73) years, and mean body mass index (BMI) of 36 ± 6.9 kg/m 2 . Median CPAP use was 10 h/d (IQR 10-11). BMI and depressive symptoms (DEPS) in the younger group were higher than in the older group (37.9 ± 7 vs. 34.6 ± 6.4 kg/m 2 , p < 0.001 and 11 (IQR 5-20) vs. 7 (IQR 5-14), p = 0.01, respectively). During follow-up, the BMI of the younger group increased (39.9 ± 12.5 kg/m 2 vs. 37.9 ± 7 kg/m 2 , p = 0.009). DEPS values decreased in the younger group and became comparable between the groups. In multivariate models, the baseline BMI independently predicted extensive CPAP use among the younger age group, and the mask leak among the older group., Conclusion: BMI at baseline in the younger and mask leak in the older group could be independent predictive factors for extensive use of CPAP., Competing Interests: Declarations Ethical approval As this retrospective study included anonymized register data, no ethics committee approval was required. Conflict of interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript., (© 2024. The Author(s).)

Published
2024
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