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5-Hydroxymethylfurfural (5-HMF) is a renewable platform chemical used as a source for obtaining diverse fine chemicals. In this letter, we report the synthesis of 5-HMF-based oxazole compounds. While 5-HMF could be easily converted into the oxazole derivative through the Van Leusen reaction, the direct arylation step needed to access the final compounds was problematic at first. After optimization, a palladium-catalyzed procedure has been developed and used for the synthesis of a series of 33 derivatives. This article reports an extension of the late-stage CH arylation reaction as an application to the oxazole platform derived from biosourced 5-HMF. The challenges in the preparation of the derivatives containing some electron-withdrawing substituents were overcome by the use of a palladium-free method.

Percutaneous penetration of chemicals from clothing can result in both acute and chronic toxicities. Although personal protective equipment composed of nonwoven material can provide thorough protection, it is often uncomfortable under normal occupational conditions. Certain everyday textiles are often utilized as protective clothing due to their cost, comfort, and convenience. Although common textiles may cover most skin, certain regions remain exposed by such outfits. The body areas covered by the fabric are at risk for fabric permeation and percutaneous penetration of chemical, either immediately or over time, dependent on the fabric composition and the characteristics of the chemical used. in vitro and in vivo publications studied percutaneous penetration of chemicals from contaminated fabric and show that everyday textiles are superior to bare skin. The increased protection offered can be attributed to properties of the fabric such as weave, thickness, fabric finish, absorbency, and the overall barrier provided. Although common textiles do offer some protection, they remain inferior to nonwoven personal protective equipment. Much remains unknown regarding percutaneous penetration and protection offered by everyday textiles.

Highlights • 2′,2′′′-Dithiobisbenzanilide (DTBBA) is a chemical used as a peptizing agent for rubber. • Humane exposure to DTBBA is possible via oral and dermal routes. • DTBBA is well-absorbed in rodents following oral and dermal administration. • Absorbed DTBBA was extensively metabolized and excreted mainly via urine. • N-(2-mercaptophenyl)benzamide accounted for more than 50% of radioactivity in urine., 2′,2′′′-Dithiobisbenzanilide (DTBBA) is a high-production-volume chemical used as a peptizing agent for rubber. The disposition and metabolism of [14C]DTBBA were determined in male and female rats and mice following oral (4, 40, or 400 mg/kg) and intravenous (IV) (4 mg/kg) administration and dermal application (0.4 or 4 mg/kg). [14C]DTBBA was well absorbed following oral administration (> 60%) and dermal application (∼40–50%) in rats and mice. Following oral administration, the majority of radioactivity was excreted in urine (29 − 70%) and feces (16 − 45%). Unlike rats, mice excreted ∼1-5% of the dose as exhaled CO2. The residual radioactivity in tissues was

This study was aimed to measure the decolorization of tattoo dyes by different chemicals and polyphenol oxidases from several plant sources. The tattoo inks removal market has burgeoned over the years, due to increased spread of tattooed persons about the world. Laser and surgery are presently the gold standards for removing of the tattoo. However, both of them have blemishes. Consequently, lots of persons were preferring easier, faster and cheaper procedures for tattoo remove. In this study polyphenol oxidases enzyme from many plant sources and different chemicals were used for decolorization of tattoo dyes in vitro. The polyphenol oxidase enzyme was used for removing of tattoo dyes (brown and blue) in order to demonstrate their potential in the treatment and decolorization of the tattoo, which is hazardous when removing by laser. The results show that 89 and 82 % of the brown and blue tattoo dyes respectively, were removed after 24 hours by enzyme extracted from Malva parviflora leaves, whereas the decolorization efficiency of polyphenol oxidase from other plant sources given less than 16% of the same dyes. The results for tattoo dyes decolorization by different chemicals revealed that Bimethylbenzylamine was the best chemical used with decolorization ratio 36 and 38 % for brown and blue tattoo dye, respectively.

Objective: There is general concern regarding environmental chemical exposure and the impact it may have on human health. This is particularly important for vulnerable populations such as infants and children during critical periods of development. Bisphenol A (BPA) is an endocrine disrupting chemical used worldwide over the last 30 years in many consumer products. Evidence points to widespread human exposure to BPA. The aim of this study was to evaluate the exposure of Turkish preschool children to BPA. Methods: This study was conducted as a preliminary investigation of BPA in urine, collected from 3-6 year old children living in Ankara. After spot urine samples were taken from preschool children, free BPA, β-D-glucuronide and total BPA were determined using high-performance liquid chromatography tandem mass spectrometry and adjusted by creatinine concentration. Results: Preschool children from Ankara (n=125; males n=70, females n=55; mean age: 4.50±1.26) were recruited. BPA was detected in 76.8% of children from Ankara city, with urinary concentrations ranging from < limit of quantification to 18.36 μg/g creatinine. Total BPA levels were not statistically different between boys (1.26 μg/g creatinine) and girls (2.24 μg/g creatinine) (p>0.05). Conclusion: This study is an important contribution to the limited information about childhood exposure to BPA. The estimated daily BPA intake in this study is substantially lower than the European Food Safety Authority derived tolerable daily intake of 4 μg/kg BW/day.

Numerous cases of acute renal failure in dogs and cats from 2004-2007 were associated with the ingestion of dog and cat pet food products and the suspected contaminant was identified as melamine and its derivatives such as cyanuric acid and melamine cyanurate. Melamine is a chemical used primarily for the manufacture of plastics, coatings, commercial filters, adhesives and compounds in the plate-making industry and kitchen appliance.But then these compounds have been abused to increase the content of nitrogen compounds in human food products and animal feed products, respectively. Increasing the content of nitrogen compounds from melamine aims to increase the value of false protein food and feed. Melamine basically has a wide security limit so it is relatively non-toxic if consumed by humans and animals. However, many studies and case reports show that melamine can cause damage to the kidneys especially if present together with cyanuric acid in the body.This paper aims to provide a simple overview and discussion in cases of damage to the urinary tract in dogs and cats that are likely caused by toxicity of melamine and its derivatives are likely to have occurred in Indonesia.

Hexavalent chromium (Cr(VI)) is a highly mutagenic and carcinogenic chemical used in many industrial processes. Occupational exposure to chromium, occurring mostly by inhalation, constitutes a major lung cancer risk affecting chromium workers. Environmental exposure, on the other hand, mainly by ingestion of contaminated drinking water, is a widespread gastrointestinal cancer risk, affecting millions of people throughout the world. One of the major mechanisms through which Cr(VI) causes carcinogenic transformation is thought to be the disruption of transcriptional regulation. Indeed, Cr(VI)-directed DNA damage and crosslinking occurs preferentially at sites where active DNA replication and transcription processes take place. Accordingly, numerous studies have shown that Cr(VI) causes gene expression changes in a wide range of cell signaling pathways, resulting from Cr(VI)-induced direct macromolecular damage, alteration in transcription factor function, and disruption of epigenetic signatures. This brief review highlights past and current information on the impact of Cr(VI) on the various mechanisms of transcriptional regulation. Impact statement This mini-review highlights current evidence on the mechanisms through which hexavalent chromium (Cr(VI)) disrupts transcriptional regulation, an emerging area of interest and one of the central processes by which chromium induces carcinogenesis. Several studies have shown that Cr(VI) causes widespread DNA damage and disrupts epigenetic signatures, suggesting that chromatin may be a direct Cr(VI) target. The findings discussed here suggest that Cr(VI) disrupts transcriptional regulation by causing genomic architecture changes.

Nitrosamine is a carcinogenic chemical used as a preservative in red meat whose identification is an ordeal. This paper presents a computer vision-based non-destructive method for identifying quality disparities between preservative treated and untreated (control) red meat. To access the discrepancy in the quality of red meat, both traditional machine learning and deep learning-based methods have been used. Support vector machine (SVM) classifier and artificial neural network (ANN) models have been used to detect the presence of nitrosamine in test samples. The paper also made use of different pre-trained deep convolutional neural networks (DCNN) with transfer learning approach such as ResNet-34, ResNet-50, ResNet-101, VGG-16, VGG-19, AlexNet and MobileNetv2 to examine the presence of nitrosamine in the food samples. While the ANN classifier performed better in comparison to the SVM classifier, the highest testing accuracy and F1-score were obtained using the deep learning model, ResNet-101 with 95.45% and 96.54%, respectively. The experimental results demonstrate an improved performance in comparison to the existing methods; indicating the feasibility of the proposed work for food quality control in real-time applications.

Salicylic acid is a common chemical used in the pharmaceutical industry. Much attention has been paid in recent years to the elimination of this contaminant from the water by electrochemical oxidation. However, there is still a debate about its intermediate products during the degradation process. The goal of this work was to provide further insight into the degradation of salicylic acid by the Density Functional Theory calculations. The detailed mechanism shall be investigated along with the most suitable intermediate products during the process. The results provide an explanation for the experimental observation of 2,3-dihydroxybenzoic acid and 2,5-dihydroxybenzoic acid over other derivatives.

Resumen El experimento se desarrolló en casa malla y se evaluó el efecto y las dosis de cuatro productos biológicos y uno químico utilizados en el control de larvas de jobotos (Phyllophaga sp.). El experimento se desarrolló en Guadalupe de Cartago. Fue una investigación cuantitativa con un diseño de experimento de bloques completos al azar, con el uso de dos dosis de cinco tratamientos, con tres repeticiones cada uno y cada repetición con diez unidades experimentales. Los productos biológicos utilizados fueron Mycotrol® 11 EW (Beauveria bassiana, cepa GHA), Botani Gard® 50 WP (Beauveria bassiana, cepa GHA), Agro Gold® (nueve cepas de Bacillus spp.), B-Green® (entomonemátodo, Heterorhabditis bacteriophora) y un producto químico comercial recomendado para control de jobotos. Se determinó que Mycotrol® 11EW (T1) en dosis de 2,25 centímetros cúbicos por litro de agua fue el producto que proporcionó los mejores resultados. De los otros dos productos que tuvieron efecto sobre el combate de esta plaga, el Agro Gold® (T3) y el B- Green® (T4), se determinó que la dosis utilizada en ambos casos no fue significativa, ya que se obtuvo valores de p iguales a 0,113 y 0,807, respectivamente. Lo que sí tuvo significancia fue realizar dos aplicaciones con frecuencia semanal con estos dos productos. Con los productos restantes, Botani Gard® 50 WP (T2) (Beauveria bassiana, cepa GHA) y T5 (producto químico comercial), no hubo resultados de significancia estadística, ya que el valor de p para T2 con el factor dosis fue de 0,573 y con el factor aplicación fue 0,094; para T5 el valor de p con el factor dosis fue 0,260 y con el factor aplicación fue 0,277. Abstract The experiment was developed at home mesh in order to evaluate the effect and dose of four biological products and one chemical used in the control of larvae of jobotos (Phyllophaga sp.). The experiment was carried out in Guadalupe, Cartago, located at the following geographic coordinates: latitude 9,861 884 and longitude -83,939 692, at 1400 m.a.s.l. The type of research was quantitative, with a design of the complete block experiment at random, and use of two doses of five treatments and three repetitions of each treatment, and each repetition with ten experimental units. The biological products used were Mycotrol® 11 EW (Beauveria bassiana, strain GHA), Botani Gard® 50 WP (Beauveria bassiana, strain GHA), Agro Gold® (nine strains of Bacillus spp.), B-Green® (entomonematode, Heterorhabditis bacteriophora), and a commercial chemical recommended for control of jobotos. For the biological control of Phyllophaga sp., it was determined that Mycotrol® 11EW, in a dose of 2,25 cc / liter of water, was the product that provided the best results. For the other two products that had an effect on the combat of Phyllophaga sp., Agro Gold® and B-Green®, it was determined that the dose used in both cases was not significant; this was confirmed by the p values of 0,113 and 0,807, respectively. What did have significance was to make two applications one week apart from each other with these two products. For the remaining products, T2 and T5, there was no statistical significance in their result. This was confirmed by the p value for T2 and T5, respectively,. For T2 it was 0,573 for the dose factor and 0,094 for the application factor. For T5 the value of p for the dose factor was 0,260 and for the application factor, 0,277.

Purpose The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of these complex molecules have relied on drug-specific studies and, in some instances, data from non-proteinaceous drug products. The commonalities, trends, and gaps in excipient technologies used to support the development of therapeutic proteins largely remain unexplored due to the drug-specific nature of many formulations. Methods Using a comprehensive and relational database approach, we aimed to provide a scientific survey of all approved or licensed biotechnology-derived drug products with the goal of providing evidence-based information on common attributes and trending features in protein product excipients. We examined 665 formulations, and 395 unique formulations based on having unique excipients within them, that supported 211 therapeutic proteins as of June 2020. Results We report the prevalence of each excipient class and excipient chemical used in eight different drug types including monoclonal antibodies, antibody conjugates, cytokines and growth factors, enzymes, polypeptide hormones, pulmonary surfactants, recombinant fusion proteins, and toxins. We also report the prevalence by excipient type among all therapeutic proteins, in the context of each drug’s recommended pH range, concentration ranges for excipients, and route of administration. Conclusions The results of our analyses indicate certain excipients common to monoclonal antibodies, cytokines, and polypeptide hormones. We also report on excipients unique to protein drug products, such as amino acids, solubilizers, and lyoprotectants. Overall, our report summarizes the current landscape of excipients used in marketed biotechnology-derived therapeutic biologic products.

The paper presents the application potential of untreated/treated woven/non-woven coir geotextile in the unpaved roads. The chemical used for the treatment of the coir geotextiles were p-aminopheno...

The increasing concern about the emerging contaminants, especially the endocrine disrupting chemicals, which include pesticides and the pharmaceuticals and personal care products, has stirred up the rate of monitoring their presence in the environment. Triclosan is one such chemical used as an antibacterial and antimicrobial in many personal care products. This chemical is present in very low amounts in the personal care products, but its appearance in the environment becomes a matter of concern due to its detrimental effects on the environment. Therefore, this paper focuses on determination of Triclosan concentration in the personal care products used by the residents of Patna municipal area. It also focuses on finding out the ultimate load of Triclosan discharged and its corresponding concentration in the wastewaters of Patna.

Morpholine is a common chemical used as emulsifier in the preparation of wax coatings for some fruit to help them remain fresh and protect against insects and fungal contamination. It has been reported that morpholine has acute toxic effects on rodents. In the present study, morpholine concentrations were analysed in fruits (citrus fruits, apples, strawberries and grapes) and juices (apple juice and orange juice) in order to determine dietary exposure among the Chinese population. A total of 732 fruit and juice samples were collected during 2015-2016, which covered major foods in China. Fruit and juice consumption data were taken from China National Nutrient and Health Survey (2002) and include data from 16,407 fruit or juice consumers. It was found that mean dietary exposure to morpholine residues from fruits and/or juices for general Chinese consumers and children 2-6 years old were 0.42 and 1.24 µg/kg bw/day, respectively. The 97.5% intake in general Chinese consumers and children 2-6 years old were 2.25 and 6.90 µg/kg bw/day, respectively. The primary food sources of the morpholine dietary intake of general Chinese consumers were citrus fruits (57.4%) and apples (40.8%). These findings suggested that dietary exposure to morpholine in the Chinese population was lower than the acceptable daily intake of morpholine, and there are no health concerns.

Sensitive real-time detection of vapors produced by the precursors, reagents and solvents used in the illegal drugs manufacture represents a priority nowadays. Acetic anhydride (AA) is the key chemical used as acetylation agent in producing the illegal drugs heroin and methaqualone. This study was directed towards quick detection and quantification of AA in air, using two fast and very sensitive analytical techniques: photoionization detection (PID) and ion mobility spectrometry (IMS). Results obtained indicated that both PID and IMS can sense AA at ultra-trace levels in air, but while PID produces a non-selective response, IMS offers richer information. Ion mobility spectrometric response in the positive ion mode presented one product ion, at reduced ion mobility K0 of 1.89 cm2 V&minus, 1 s&minus, 1 (almost overlapped with positive reactant ion peak), while in the negative ion mode two well separated product ions, with K0 of 1.90 and 1.71 cm2 V&minus, 1, were noticed. Our study showed that by using a portable, commercial IMS system (model Mini IMS, I.U.T. GmbH Berlin) AA can be easily measured at concentrations of 0.05 ppmv (0.2 mg m&minus, 3) in negative ion mode. Best selectivity and sensitivity of the IMS response were therefore achieved in the negative operation mode.

Rapidly increasing pyrethroid insecticide resistance and changes in vector biting and resting behavior pose serious challenges in malaria control. Mosquito repellents, especially spatial repellents, have received much attention from industry. Many of these repellents contain the same or similar chemicals as those used in insecticides. Does resistance to insecticides affect the efficacy of spatial repellents? We attempted to simulate interactions between mosquitoes and repellents using a machine learning method, the self-propelled particle (SPP) model, which we modified to include attractiveness/repellency effects. We simulated a random walk scenario and scenarios with insecticide susceptible/resistant mosquitoes against repellent alone and against repellent plus attractant (to mimic a human host). We assumed attractant odors and repellent chemicals diffused randomly and omnidirectionally, and that mosquitoes were confined in a cubic cage. We modified the velocity and direction components of SPP using attraction/repulsion rates and concentrations. Simulation results indicated that without attractant/repellent, mosquitoes would fly anywhere in the cage at random. With attractant, mosquitoes might or might not fly toward the source (i.e., the human), depending on the simulation time (and thus the attractant concentration distribution). Eventually, however, all mosquitoes were attracted to the source of the odor. With repellent, results depended on the amount of chemical used and the level of mosquito insecticide resistance. All insecticide-susceptible mosquitoes eventually moved to the corner of the cage farthest from the repellent release point. Surprisingly, a high proportion of highly resistant mosquitoes might reach the attractant release point (the human) earlier in the simulation when repellent was present compare to no repellent was present. At fixed concentration, a high proportion of mosquitoes could be able to reach the host when the relative repellency efficacy (compare to attractant efficacy) was 1. This result implies that repellent may not be sufficient against highly physiologically insecticide resistant mosquitoes, since very high concentrations of repellent are neither practically feasible nor cost-effective.

Before long a days, constant undertakings made on solid found that changing substance sytheses in solid show various highlights. Generally different conditions, such solid that could be made obviously by relative degrees of the oxide pieces were not seen as adequate. Tests have been taken to add new materials to the solid known as included substances, at the hour of beating or by changing significant unrefined materials during the making of cement.

Triclosan (TCS), a chemical used for its antibacterial properties, is an ingredient in many detergents, soaps, deodorants, cosmetics, antimicrobial creams, toothpastes, and an additive in various plastics and textiles. The behavioral changes at different TCS concentrations (0.001–0.002–0.005–0.01–0.02–0.05–0.1–0.2–0.5 mg/L) were determined for the each test organisms in the study. The synthetic freshwater has temperature 20 ± 2°C, dissolved oxygen 7.0 ± 2 mg/L, pH 7.0–8.0. All experiments were replicated three times, in 14 h light, 10 h dark incubations, 10 fishes were put to each aquarium. In hourly and daily observations, times of dead and number for Poecilia reticulata, Danio rerio were recorded. Behavioral changes of Poecilia reticulata and Danio rerio were observed, such as fast-moving, uncontrolled swimming, trying to escape out of the water, vertical action to the water surface, loss of balance, respiratory difficulties, chills, and inversion. © 2018 Taylor & Francis Group, LLC.

The present study was conducted in Gulbarga district of Karnataka during the year 2012-13. Based on highest number of vermicomposting pits, four taluks namely Gulbarga, Jewargi, Aland and Afazalpur were purposively selected and from each taluk, two villages were selected and from each village, fifteen farmers were selected randomly. Thus, the total sample size constitutes 120 respondents for the study. The ex-post facto research design was used for the study. The data were collected using pre-tested structured interview schedule personally. The collected data were analyzed using appropriate statistical tools. The results of the study revealed that, about 70 per cent of the farmers were between medium to high knowledge category about vermicomposting and majority of them were having knowledge in recommended pit size, pre decomposition of raw material before filling pits and management of ants and termites. More than 70 per cent of the farmers belonged to high adopter category. More than 80 per cent of farmers adopted the recommended practices like the chemical used for pest management, size of the pit and dosage of chemical used for management of ants and termites. The independent variables like land holding, extension participation, mass media utilization of the farmers had shown the positive and significant relationship with their knowledge level and land holding, annual income and scientific orientation exhibited positive and significant relationship with their adoption level.

Hydrazine is highly toxic to humans and animals when inhaled or in contact with the skin. It is also a very important chemical used as propellant, metal corrosion inhibitor, pharmaceutical and intermediate. The simple detection of hydrazine in solution and biosystems becomes very important as a consequence of the foregoing applications. Herein, we report a two-photon fluorescent probing method using a NIR fluorescent chemodosimeter, displaying turn-on fluorescence and color change after cleaving an O -acetyl moiety by hydrazine, which exhibits good selectivity and sensitively in solution and living cells.

The specialty amine catalyst 2,2′-dimorpholinodiethyl ether (DMDEE) is a high-production volume chemical used in the production of flexible foam, high-resilient molded foam, and in coatings and adhesives. The disposition and metabolism of [14C]DMDEE (20 or 200 mg/kg) were determined in male ane female rats and mice after oral and intravenous administration and dermal application.In male and female rats, following a single oral administration, [14C]DMDEE was well-absorbed and excreted rapidly and extensively via urine (75–93%) and some in feces (∼4–8%). The total radioactivity in tissues at 24 h and 72 h (males only) following oral administration was 8–10% and ∼4%, respectively, suggesting considerable tissue distribution. A moderate amount of the total tissue radioactivity in kidney and liver were unextractable suggesting covalent binding of [14C]DMDEE-derived products in tissue macromolecules.Absorption following a single dermal application in rats was significant (∼64%) with a similar disposition pattern to oral.The oral and dermal disposition of [14C]DMDEE in male and female mice was similar to rats.Urinary products of DMDEE identified were oxidative metabolism of the morpholine ring.Coadministration of DMDEE with nitrite in rats didn’t produce the rodent carcinogen, N-nitrosomorpholine. The specialty amine catalyst 2,2′-dimorpholinodiethyl ether (DMDEE) is a high-production volume chemical used in the production of flexible foam, high-resilient molded foam, and in coatings and adhesives. The disposition and metabolism of [14C]DMDEE (20 or 200 mg/kg) were determined in male ane female rats and mice after oral and intravenous administration and dermal application. In male and female rats, following a single oral administration, [14C]DMDEE was well-absorbed and excreted rapidly and extensively via urine (75–93%) and some in feces (∼4–8%). The total radioactivity in tissues at 24 h and 72 h (males only) following oral administration was 8–10% and ∼4%, respectively, suggesting considerable tissue distribution. A moderate amount of the total tissue radioactivity in kidney and liver were unextractable suggesting covalent binding of [14C]DMDEE-derived products in tissue macromolecules. Absorption following a single dermal application in rats was significant (∼64%) with a similar disposition pattern to oral. The oral and dermal disposition of [14C]DMDEE in male and female mice was similar to rats. Urinary products of DMDEE identified were oxidative metabolism of the morpholine ring. Coadministration of DMDEE with nitrite in rats didn’t produce the rodent carcinogen, N-nitrosomorpholine.

Carbon black is an important industrial chemical used as raw material for many other industries like rubber, polymer, paints, etc. This is produced at very high temperature by cracking heavy feedstocks in specially designed reactors. This chapter has discussed the different designs of reactors with process details. The different zones of the reactors are shown, and the refractories used in different zones for the reactors are discussed in detail.

There is perhaps no endocrine disrupting chemical more controversial than bisphenol A (BPA). Comprising a high-volume production chemical used in a variety of applications, BPA has been linked to a litany of adverse health-related outcomes, including effects on brain sexual differentiation and behaviour. Risk assessors preferentially rely on classical guideline-compliant toxicity studies over studies published by academic scientists, and have generally downplayed concerns about the potential risks that BPA poses to human health. It has been argued, however, that, because traditional toxicity studies rarely contain neural endpoints, and only a paucity of endocrine-sensitive endpoints, they are incapable of fully evaluating harm. To address current controversies on the safety of BPA, the United States National Institute of Environmental Health Sciences, the National Toxicology Program (NTP), and the US Food and Drug Administration established the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA). CLARITY-BPA performed a classical regulatory-style toxicology study (Core study) in conjunction with multiple behavioural, molecular and cellular studies conducted by academic laboratories (grantee studies) using a collaboratively devised experimental framework and the same animals and tissues. This review summarises the results from the grantee studies that focused on brain and behaviour. Evidence of altered neuroendocrine development, including age- and sex-specific expression of oestrogen receptor (ER)α and ERβ, and the abrogation of brain and behavioural sexual dimorphisms, supports the conclusion that developmental BPA exposure, even at doses below what regulatory agencies regard as "safe" for humans, contribute to brain and behavioural change. The consistency and the reproducibility of the effects across CLARITY-BPA and prior studies using the same animal strain and almost identical experimental conditions are compelling. Combined analysis of all of the data from the CLARITY-BPA project is underway at the NTP and a final report expected in late 2019.

Bisphenol-A (BPA) is a synthetic chemical used in the manufacturing of polycarbonates and epoxy resins. This paper is a review of studies reporting the occurrences and concentrations of BPA in the environment and associated impact on human health. Studies have found that at high temperature conditions such as open burning of dumped waste in developing nations can relocate BPA from plastic waste into the environment. BPA is a proven endocrine disruptor capable of mimicking or blocking the receptors and altering hormone concentrations and its metabolism. Even though it is consumed in a low dose, it can stimulate cellular responses and affect body functions. Biomonitoring studies show that human and animal exposure to BPA is rapid and continuous. In-depth studies are needed to understand the fate of these compounds particularly in the developing nations and the associated adverse health impacts of BPA due to prolonged exposure.

In the US, the toxicity characteristic leaching procedure (TCLP) determines if a waste is toxicity characteristic (TC) hazardous based on leached concentrations of specific chemicals. The TC limits were originally derived from drinking water standards (DWS) adjusted by a dilution attenuation factor of 100. The TC limits have not been updated along with DWS revisions. This research examines potential implications of updating the TC limits to account for new DWS thresholds and elements, as well as tap-water risk thresholds; this allows a further expanded evaluation of elements that might be regulated as drinking water standards in the future. Fossil fuel combustion residues, batteries, electronic wastes, municipal solid waste incineration (MSWI) ashes, and treated wood were examined with TCLP and the leached metal concentrations were compared to revised TC thresholds. The two wastes most affected by updated TC limits would be batteries and MSWI ashes. Thallium and antimony, which were not included on the original TC list, exceeded the TC thresholds for batteries and MSWI ash, respectively. Copper, a chemical used in current preserved wood formulations, did not cause currently marketed treated wood to be hazardous waste, but arsenic did for older wood products.

Hydroquinon is a chemical used as a skin lightener. However, its effectiveness began to be questioned after the emergence of a study showing that hydroquinone can trigger cancer. This study aims to analyze the hydroquinone content of several doctor-made creams and branded facial lightening creams circulating in Denpasar. This research is an experimental research. The sample used consisted of five samples of doctor-made creams coded D1-D5, while branded lightening creams were coded P1-P10. Based on the results of the analysis, the wavelength of 293 nm is the wavelength that provides maximum absorption with the equation y = 0.023x + 0.005 with a value of R2 = 0.996. 0.023. The results of the analysis showed that all samples of the doctor's cream contained hydroquinone with an average of 11.9322 ppm or 1.1932% and did not exceed the BPOM regulations, namely 5% for cream preparations prescribed by doctors. And all samples of branded facial lightening creams in Denpasar City contain hydroquinone with an average hydroquinone level of 3,987 ppm or 0.3987% and do not exceed the BPOM regulations, which is 2% for whitening cream preparations that are sold freely without a doctor's prescription.

Background: Latex protective barriers such as gloves and rubber dam material have been used widely in restorative procedures for crown and bridge. However, the chemical used during latex glove fabrication is thought to inhibit the polymerization of elastomeric impression materials used for impression making which has a detrimental effect on the dimensional accuracy and surface definition of resultant casts used for restorative procedures. The objectives of the study were to examine the surface of different elastomeric impressions on contact with various gloves. Materials and Methods: This clinical study included a total of eighty specimens of two types of the putty elastomeric impression material were hand manipulated by wearing three different gloves materials and is placed on a marked area of a clean and alcohol-treated glass slab at room temperature. The specimens examined for any signs of polymerization inhibition. The specimen will be rated as being “inhibited” if any residue remains on the glass slab and absence of the above will result as “no inhibition.” Results: The results showed no interference with the polymerization inhibition of the selected elastomers followed by the nitrile glove. The latex gloves showed inhibited set of the elastomeric impression material but set after sometime confirming time-dependent inhibition of the impression material. Conclusion: This study shows that the use of latex and sometime nitrile gloves during crown and bridge procedures should be contraindicated and the use of vinyl gloves should be stressed when working with elastomeric impression materials.

We demonstrate the application of a high-throughput modeling framework to estimate exposure to chemicals used in personal care products (PCPs). As a basis for estimating exposure, we use the product intake fraction (PiF), defined as the mass of chemical taken by an individual or population per mass of a given chemical used in a product. We calculated use- and disposal- stage PiFs for 518 chemicals for five PCP archetypes. Across all product archetypes the use- and disposal- stage PiFs ranged from 10−5 to 1 and 0 to 10−3, respectively. There is a distinction between the use-stage PiF for leave-on and wash-off products which had median PiFs of 0.5 and 0.02 across the 518 chemicals, respectively. The PiF is a function of product characteristics and physico-chemical properties and is maximized when skin permeability is high and volatility is low such that there is no competition between skin and air losses from the applied product. PCP chemical contents (i.e. concentrations) were available for 325 chemicals and were combined with PCP usage characteristics and PiF yielding intakes summed across a demonstrative set of products ranging from 10−8–30 mg/kg/d, with a median of 0.1 mg/kg/d. The highest intakes were associated with body lotion. Bioactive doses derived from high-throughput in vitro toxicity data were combined with the estimated PiFs to demonstrate an approach to estimate bioactive equivalent chemical content and to screen chemicals for risk.

Melamine is a synthetic chemical used in the manufacture of resins, pigments, and superplasticizers. Human beings can be exposed to melamine through various sources such as migration from related products into foods, pesticide contamination, and illegal addition to foods. Toxicity studies suggest that prolonged consumption of melamine could lead to the formation of kidney stones or even death. Therefore, reliable and accurate detection methods are essential to prevent human exposure to melamine. Sample preparation is of critical importance, since it could directly affect the performance of analytical methods. Some methods for the detection of melamine include instrumental analysis, immunoassays, and sensor methods. In this paper, we have summarized the state-of-the-art methods used for food sample preparation as well as the various detection techniques available for melamine. Combinations of multiple techniques and new materials used in the detection of melamine have also been reviewed. Finally, future perspectives on the applications of microfluidic devices have also been provided.

Asthma, one of the leading chronic diseases, has a high prevalence among young adults or adolescents. Students with the asthmatic attack have been reported to miss several days in school which often leads to an increasing rate of absenteeism in school, hospital visitation, morbidity, and mortality. Asthma attacks have also been revealed to have some psychological effect on those having them. There are many things that do trigger asthma attacks and one of them is formaldehyde that is the chief embalming chemical used in many medical schools. One major problem is how to handle a situation when the choice of one's career is being surrounded by triggers that can lead to an asthma attack. This paper discusses some of the measures to be taken to avoid any form of an asthma attack in the course of study, especially in the human anatomy dissecting hall.

The US Environmental Protection Agency has agreed to evaluate the risks of octamethylcyclotetrasiloxane (D4), a cyclic organosilicon chemical used in numerous commercial and consumer products. Earl...

A chemical used for dry cleaning, degreasing of industrial equipment, and production of fluorinated refrigerants poses unreasonable health risks to workers and consumers, the US Environmental Prote...

Ripening of fruit is a natural process. Ethylene is responsible for ripening process which is produced naturally in fruit. But dealers and sellers often use chemicals like CaC2 (Calcium carbide) to quicken this process so their product will enter the market early and they can maximize profit. Fruits are kept in storage with chemicals. This chemical mixes with moisture and produces ethylene which causes ripening of the fruit. Since the ethylene is high in quantity and it contacts with the surface area of the fruit it causes uniform ripening of the fruit unlike when the fruit is ripened naturally it causes uneven ripening of the fruit since natural ethylene present in the fruits is un-uniformly distributed. Consuming such fruit is harmful to human health. It can cause headache, stomach irritation, throat irritation, digestion problem and since the chemical used is carcinogenic it can also cause cancer and it also degrades the taste and quality of the fruit. Finding out the artificially ripened fruit with the human eye is difficult. So, the proposed system gets an image of fruit under the test and compare it with the features of naturally ripened fruit and artificially ripened fruit and give the output with the probability. This method makes usage of smartphone which runs the android application and the convolutional neural network to detect the artificially ripened fruit.

Bisphenol A is a commercially important chemical used to make polycarbonate plastic, epoxy resins, and other specialty products. Despite an extensive body of in vitro, animal and human observational studies on the effects of exposure to bisphenol A, no authoritative bodies in the U.S. have adopted or recommended occupational exposure limits for bisphenol A. In 2017, the National Institute for Occupational Safety and Health published a Draft process for assigning health-protective occupational exposure bands, i.e., an airborne concentration range, to chemicals lacking an occupational exposure limit. Occupational exposure banding is a systematic process that uses both quantitative and qualitative toxicity information on selected health effect endpoints to assign an occupational exposure band for a chemical. The Draft process proposes three methodological tiers of increasing complexity for assigning an occupational exposure band. We applied Tier 1 (based on the Globally Harmonized System of Classification and Labelling) and Tier 2 (based on authoritative sources/reviews) to assign an occupational exposure band to bisphenol A. Under both Tier 1 and 2, the occupational exposure band for bisphenol A was “E” (3), an assignment based on eye damage. “E” is the lowest exposure concentration range, reserved for chemicals with high potential toxicity. If eye damage was excluded in assigning an air concentration exposure range, then bisphenol A would band as “D” (>0.01 to 0.1 mg/m3) under Tier 1 (based on reproductive toxicity and respiratory/skin sensitization) and under Tier 2 (based on specific target organ toxicity-repeated exposure). In summary, Tiers 1 and 2 gave the same occupational exposure band for bisphenol A when eye damage was included (“E”) or excluded (“D”) as an endpoint.

Octamethylcyclotetrasiloxane (D4), a cyclic organosilicon chemical used as an intermediate to make numerous commercial and consumer products, does not pose risks to human health or the environment,...

An antiseptic is a chemical used in medicine to prevent wound infection and, subsequently, sepsis. They are used in wound care as a therapeutic as well as a preventive measure. Unlike antimicrobial therapeutics (antibiotics), antiseptics are applied to the surface of nonliving objects to destroy microorganisms that are living on the objects.

Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in over 2000 consumer products such as toothpastes, cosmetics, and toys. Due to its widespread use, it causes ubiquitous contamination in the environment and is frequently detected in the human body, raising concerns about its impact on environmental pollution and human health. Our recent study showed that short-time exposure to low-dose TCS causes colonic inflammation, increases severity of colitis, and exacerbates colitis-associated colon tumorigenesis in mice, through gut microbiota- and Toll-like receptor 4 (TLR4)-dependent mechanisms. In addition, we demonstrate that beyond TCS, other antimicrobial chemicals used in consumer products also exaggerate colitis and colon cancer in mice. Together, these results highlight the importance to further evaluate these consumer antimicrobials on gut health, to develop potential further regulatory policies.

Cyclohexanone is a chemical used in various industries and many workers are exposed to it. Therefore, in this study, we determined the toxicity of cyclohexanone in inhalation-exposed F344 rats and B6C3F1 mice, so as to apply the findings in hazard and risk assessments.Ten male and 10 female rats and mice per test group were exposed to cyclohexanone vapors at 0, 100, 250, and 625 ppm concentrations for 6 h per day, 5 d per week, and for 13 weeks. All rats and mice were killed after the exposure period. Clinical signs, body weight, feed intake, and ophthalmoscopy findings were recorded during the exposure period, and hematology, blood biochemistry, organ weights, gross findings, and histopathology were evaluated thereafter.The following findings were noted in cyclohexanone-exposed F344 rats: increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, increased liver weight, and bile duct hyperplasia in the males exposed to 250 and 625 ppm cyclohexanone, increased ALT levels and bile duct hyperplasia in the females exposed to 625 ppm cyclohexanone, and increased blood urea nitrogen (BUN) and tubular basophilia in the renal cortex in the males exposed to 625 ppm cyclohexanone. On the other hand, B6C3F1 mice exposed to cyclohexanone showed no obvious exposure-related effects.Based on the findings, the no-observed-adverse-effect level (NOAEL) was determined to be 100 ppm in F344 rats and625 ppm in B6C3F1 mice. Therefore, 2 ppm was revealed as the derived no-effect level (DNEL) for cyclohexanone.

Due to its endocrine disrupting nature Bisphenol-A (BPA), a chemical used in the plastic industry was placed under a ban which provided an incentive for its replacement by bisphenol and non-bisphenol based plasticizers. The use of bisphenol replacements in industry is increasing day by day. Therefore, it becomes prudent to put them under scrutiny. We studied the direct interaction of 45 BPA replacements and BPA with 12 nuclear receptors using an endocrine disruptome docking program (Kolsek et al., 2014b). Infact, the mechanism which could involve a direct interaction of ligands with nuclear receptors was taken into consideration. We found that the replacements, which were analogues of BPA, easily interacted with nuclear receptors due to the presence of phenyl moiety and their hydrophobic nature probably crucial for their endocrine disrupting potential. We therefore, strongly recommend reconsideration of BPA analogues in industries.

Bisphenol A (BPA) is a chemical used in the production of numerous consumer products resulting in potential daily human exposure to this chemical. The FDA previously evaluated the body of BPA toxicology data and determined that BPA is safe at current exposure levels. Although consistent with the assessment of some other regulatory agencies around the world, this determination of BPA safety continues to be debated in scientific and popular publications, resulting in conflicting messages to the public. Thus, the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS), and U.S. Food and Drug Administration (FDA) developed a consortium-based research program to link more effectively a variety of hypothesis-based research investigations and guideline-compliant safety testing with BPA. This collaboration is known as the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA). This paper provides a detailed description of the conduct of the study and a midterm update on progress of the CLARITY-BPA research program.

As part of an initiative to evaluate commercial chemicals for their effects on human and environmental health, Canada recently evaluated decamethylcyclopentasiloxane (D5; CAS no. 541-02-06), a high-volume production chemical used in many personal care products. The evaluation illustrated the challenges encountered in environmental risk assessments and the need for the development of better tools to increase the weight of evidence in environmental risk assessments. The present study presents a new risk analysis method that applies thermodynamic principles of fugacity and activity to express the results of field monitoring and laboratory bioaccumulation and toxicity studies in a comprehensive risk analysis that can support risk assessments. Fugacity and activity ratios of D5 derived from bioaccumulation measures indicate that D5 does not biomagnify in food webs, likely because of biotransformation. The fugacity and activity analysis further demonstrates that reported no-observed-effect concentrations of D5 normally cannot occur in the environment. Observed fugacities and activities in the environment are, without exception, far below those corresponding with no observed effects, in many cases by several orders of magnitude. This analysis supports the conclusion of the Canadian Board of Review and the Minister of the Environment that D5 does not pose a danger to the environment. The present study further illustrates some of the limitations of a persistence-bioaccumulation-toxicity-type criteria-based risk assessment approach and discusses the merits of the fugacity and activity approach to increase the weight of evidence and consistency in environmental risk assessments of commercial chemicals.

Multi-functional scouring agent (M.F.S.A.) successfully can replace caustic soda, soda ash, scouring agent and H2O2 –bleach stabilizer. It has strong properties of washing, dispersing, emulsifying and chelating, particularly applicable to bleach bath. In this experiment three processes like desizing, scouring and bleaching were done by single stage. Grey fabrics (woven) were treated by using various concentrations of M.F.S.A. and H2O2 at different temperature variation. The maximum value of whiteness of treated fabric were found at 80°C by using the concentration of M.F.S.A. and H2O2 (3.0 g/L and 3.0 g/L respectively). Also minimize required number of chemical used for bleaching process; here only two chemicals used for whole process. No additional chemicals used for water treatment and washing of treated fabric. After process only cold wash were done. Finally by using less concentration of both M.F.S.A. and H2O2 have got comparatively better result for whiteness and tensile strength.

Collagen sponges and membranes which are used as medical device and in tissue engineering (TE) were sterilised by using supercritical carbon dioxide (CO 2 sc ) which was doted with hydrogen peroxide (300 mg/L). Sterilisation was achieved by pressure change treatment (20.5–10 MPa). Neither physical nor structural and biological parameters of the materials were negatively affected. In contrast, sterilisation by gamma-irradiation led to increased solubility and decreased physical stability. As H 2 O 2 is a common chemical used in collagen processing in industrial scale this could become a sterilisation technique for medical devices and TE materials on collagen basis.

Many chemicals used as medical treatments can cause chemical burns as an untoward side effect. One of such chemicals is potassium permanganate. It is a caustic chemical used as a disinfectant. The most common sites of burn by potassium permanganate are exposed sites like the face and hands. Chemical burns in the perianal and anal region are rare in clinical practice and even sparser in the pediatric age group. In this article, we report a case of perianal and anal chemical burn in an 18-month-old, male child, caused by potassium permanganate crystal applied wrongly for the treatment of pinworm infestation. As a chemical burn in this region can have serious complications, it is necessary to be vigilant when using such chemicals in these cases. Early and timely management in such cases leads to good outcomes. This is the first of such cases of chemical burn caused by potassium permanganate in the anal and perianal region.

Background/Aim: Triclosan, an antimicrobial chemical used in some consumer products, is ubiquitous among pregnant women. Gestational exposure may reduce the levels of thyroid hormones important for...

White ledger usually includes white office paper, computer paper, and copy machine paper. Because these grades need high optical properties, fluorescent whitening agents (FWAs) are widely used in the papermaking process. FWAs are the most powerful and effective chemical used to obtain high CIE whiteness and ISO brightness in papers. The rising demand for white or ultra-white papers has increased the use of FWAs. However, FWAs used in white ledger can restrict its use, even though white ledger is widely used as a raw material in paperboard mills. Therefore, it is necessary to develop methods to control FWAs from white ledger to increase its use in paperboard mills. In this study, the behaviors of disulpho fluorescent whitening agent (D-FWA), tetrasulpo fluorescent whitening agent (T-FWA), and hexasulpho fluorescent whitening agent (H-FWA) during the recycling process were identified as a first step to remove FWAs from white ledger. We prepared four types of pa-pers (dyed with D-FWA, T-FWA, and H-FWA), disintegrated these papers, and made handsheets. This recycling process was carried out three times in a laboratory. After each round of recycling, the hand-sheets' CIE whiteness and fluorescence index were measured, and the distribution of FWAs in the Z-di

Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of the present study was to determine whether increased BPA exposure from consumption of canned beverage actually affects blood pressure and heart rate variability. We conducted a randomized crossover trial with noninstitutionalized adults, who were aged ≥60 years and recruited from a local community center. A total of 60 participants visited the study site 3 times, and they were provided the same beverage in 2 glass bottles, 2 cans, or 1 can and 1 glass bottle at a time. The sequence of the beverage was randomized. We then measured urinary BPA concentration, blood pressure, and heart rate variability 2 hours after the consumption of each beverage. The paired t test and mixed model were used to compare the differences. The urinary BPA concentration increased after consuming canned beverages by >1600% compared with that after consuming glass bottled beverages. Systolic blood pressure adjusted for daily variance increased by ≈4.5 mm Hg after consuming 2 canned beverages compared with that after consuming 2 glass bottled beverages, and the difference was statistically significant. The parameters of the heart rate variability did not show statistically significant differences.The present study demonstrated that consuming canned beverage and consequent increase of BPA exposure increase blood pressure acutely.

Nanoparticle TiO2 is a common chemical used in daily life. As increasing usage of TiO2, it is becoming a potentially dangerous contaminant to the environment. However, the impact of TiO2 is not well understood. In this paper, switchgrass was employed to investigate the impacts of nanoparticle TiO2 on plant growth and development as well as the potential impact on the expression of microRNAs (miRNAs). TiO2 significantly affected switchgrass seed generation as well as plant growth and development in a dose-dependent manner. Particularly, TiO2 significantly inhibited root development. miRNA expressions were also significantly altered. Nanoparticle TiO2 may regulate plant development through controlling the expression of certain miRNAs. Among the 16 tested miRNAs, the expression of some miRNAs, such as miR390 and miR399 was increased with increasing TiO2 concentrations; the expression of some miRNAs, such as miR169 was decreased with increasing TiO2 concentrations; the other miRNAs show different expression patterns.

To investigate the association between urinary triclosan concentrations and antral follicle count (AFC), a well-accepted marker of ovarian reserve, among women from a fertility center.Prospective cohort study.Hospital fertility center.A total of 109 women.Urinary triclosan concentrations quantified by online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry.AFC through transvaginal ultrasonography on the third day of an unstimulated menstrual cycle or on the third day of a progesterone withdrawal bleed.The geometric mean of the specific gravity-adjusted urinary triclosan concentrations for the 225 samples provided by the 109 women was 13.0 μg/L (95% confidence interval [CI], 8.9, 19.1). Women had median (with interquartile range) AFC of 13 (8, 18). The specific gravity-adjusted urinary triclosan concentrations were inversely associated with AFC (-4%; 95% CI, -7%, -1%). Women with triclosan concentrations above the median had lower AFC compared with those whose triclosan concentrations were equal to or below the median, with an adjusted difference of -3.2 (95% CI, -3.9, -1.6) among those with a body mass index25 kg/mSpecific gravity-adjusted urinary triclosan concentrations were inversely associated with AFC in women seeking care at a fertility center. This association was modified by age and body mass index, with the younger and leaner women showing larger decreases in AFC.