1. Matrix metalloproteinases in aortic dissection.
- Author
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Zhou S, Ma B, and Luo M
- Subjects
- Humans, Animals, Matrix Metalloproteinase Inhibitors therapeutic use, Matrix Metalloproteinase Inhibitors pharmacology, Signal Transduction, Aorta enzymology, Aorta pathology, Aorta metabolism, Aortic Dissection enzymology, Aortic Dissection pathology, Aortic Dissection metabolism, Matrix Metalloproteinases metabolism, Aortic Aneurysm enzymology, Aortic Aneurysm metabolism, Aortic Aneurysm pathology, Extracellular Matrix metabolism, Extracellular Matrix enzymology, Extracellular Matrix pathology
- Abstract
Aortic dissection, characterized by a high immediate mortality, is primarily caused by excessive bleeding within the walls of the aorta or a severe tear within the intimal layer of the aorta. Inflammation, as well as oxidative stress and the degradation of extracellular matrix (ECM), are significant factors in the development and occurrence of aortic dissection. Matrix metalloproteinases (MMPs) are pivotal enzymes responsible for degrading the ECM. Inflammatory factors and oxidants can interact with MMPs, indicating the potential significance of MMPs in aortic dissection. A substantial body of evidence indicates that numerous MMPs are significantly upregulated in aortic dissection, playing a critical role in ECM degradation and the pathogenesis of aortic dissection. Furthermore, targeting these enzymes has demonstrated potential in facilitating ECM restoration and reducing the incidence of aortic dissection. This review initially provides a brief overview of MMP biology before delving into their expression patterns, regulatory mechanisms, and therapeutic applications in aortic dissection. A profound comprehension of the catabolic pathways associated with aortic dissection is imperative for the future development of potential preventive or therapeutic bio-interventions for aortic dissection., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
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