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3 results on '"Fatih Sokmen"'

1. Renal Tubular Acidosis in Patients with Systemic Lupus Erythematosus

Author

Necmi Eren, Ozkan Gungor, Feyza Nur Sarisik, Fatih Sokmen, Didem Tutuncu, Gozde Yildirim Cetin, Ayten Yazici, Sibel Gökçay Bek, Eda Altun, Orcun Altunoren, and Ayse Cefle

Subjects
glomerular filtration rate, proteinuria, renal tubular acidosis, systemic lupus erythematosus, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Objective: Renal tubular acidosis (RTA) is a clinical manifestation that occurs with insufficiency in restoring bicarbonate or disruption in hydrogen ion elimination as a result of a disruption in tubulus functions, causing normal anion gap-opening metabolic acidosis. In the present study, we aimed to investigate the prevalence of RTA in the largest systemic lupus erythematosus (SLE) patient population to date. Materials and Methods: SLE patients, who were followed up in 2 different healthcare centers, were included. Patients with metabolic acidosis (pH

Published
2020
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2. Renal Tubular Acidosis in Patients with Systemic Lupus Erythematosus

Author

Didem Tutuncu, Eda Altun, Sibel Gokcay Bek, Feyza Nur Sarisik, Ayse Cefle, Necmi Eren, Fatih Sokmen, Ayten Yazici, Ozkan Gungor, Gozde Yildirim Cetin, and Orcun Altunoren

Subjects
Adult, Male, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, viruses, Anion gap, Renal function, lcsh:RC870-923, Gastroenterology, Renal tubular acidosis, chemistry.chemical_compound, systemic lupus erythematosus, Internal medicine, lcsh:Dermatology, medicine, Humans, Lupus Erythematosus, Systemic, Acid-Base Equilibrium, glomerular filtration rate, Creatinine, Proteinuria, business.industry, Metabolic acidosis, Acidosis, Renal Tubular, General Medicine, Venous blood, Middle Aged, biochemical phenomena, metabolism, and nutrition, lcsh:RL1-803, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, chemistry, lcsh:RC666-701, Nephrology, Urine anion gap, Female, proteinuria, renal tubular acidosis, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Objective: Renal tubular acidosis (RTA) is a clinical manifestation that occurs with insufficiency in restoring bicarbonate or disruption in hydrogen ion elimination as a result of a disruption in tubulus functions, causing normal anion gap-opening metabolic acidosis. In the present study, we aimed to investigate the prevalence of RTA in the largest systemic lupus erythematosus (SLE) patient population to date. Materials and Methods: SLE patients, who were followed up in 2 different healthcare centers, were included. Patients with metabolic acidosis (pH 3 Results: A total of 108 patients were included in the present study. The mean age of the patients was 41.5 ± 1.2 and 87% were female. The SLE diagnosis duration was 75 ± 5 months. The mean creatinine value ​​was 0.6 ± 0.1 mg/dL and the mean eGFR was 111 ± 2 mL/min. According to the blood gas analysis, 18 patients (16.7% of the total) had RTA. Sixteen of these patients had type 1 RTA and 2 had type 2 RTA; type 4 RTA was not determined in any of the patients. Conclusion: RTA should be considered in SLE patients even if they have normal eGFR values. This is the largest study to examine the prevalence of RTA in SLE patients in the literature.

Published
2020
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3. Does neutrophyl to lymphocyte ratio really predict chronic kidney disease progression?

Author

Songul Isiktas, Orcun Altunoren, Ozkan Gungor, Muhammed Ciftcioglu, Feyza Nur Sarisik, Ertugrul Erken, Didem Tutuncu Sezal, Merve Uyan, Mahmut Egemen Senel, Fatma Betul Guzel, Gül İnci Törün, Gulsum Akkus, Murat Fatih Sokmen, and Hatıce Ayyildiz Sevim

Subjects
Male, Nephrology, medicine.medical_specialty, Turkey, Neutrophils, Urology, medicine.medical_treatment, Lymphocyte, 030232 urology & nephrology, Renal function, 030204 cardiovascular system & hematology, urologic and male genital diseases, Gastroenterology, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Diabetes mellitus, Internal medicine, medicine, Humans, Lymphocytes, Renal replacement therapy, Renal Insufficiency, Chronic, Stage (cooking), Aged, Inflammation, Proteinuria, business.industry, fungi, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Renal Replacement Therapy, medicine.anatomical_structure, Disease Progression, Female, medicine.symptom, business, Follow-Up Studies, Glomerular Filtration Rate, Kidney disease
Abstract

Chronic kidney disease (CKD) is an inflammatory process. In addition to increased morbidity and mortality, inflammation also contributes to the progression of CKD. Neutrophil/lymphocyte ratio (NLR) is a marker of inflammation. Some recent data suggest that NLR may predict the progression of CKD. In this study, 5-year data of 740 patients with stage 2–4 CKD were reviewed retrospectively. Demographic data, NLR, CRP, albumin, the amount of proteinuria were recorded. At the beginning and the end of follow-up the glomerular filtration rate (GFR) and the annual GFR decline rate were calculated. Patients were divided to high and low NLR group according to median value of their baseline NLR. Reaching stage 5 CKD or initiation of renal replacement therapy was determined as end-point for follow-up. The mean age was 62.8 ± 0.57 years, eGFR 40 ml/min/1.73 m2, median NLR was 2.76. NLR increased as the CKD-stage increased. Mean follow-up time was 51.2 ± 30 months and 21.4% of patients reached the end-point. NLR was significantly increased at follow-up (from 3.22 to 5.68, p

Published
2018
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