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Graphical abstract Novel Di-and tetranuclear copper(II) complexes have been synthesized and structurally characterized. The interaction with DNA of two complexes in non-intercalation binding mode was confirmed by spectroscopic studies and molecular docking. The two compounds show cytotoxicity against HeLa cells and AGZY-83a cell lines via an apoptotic cell death mechanism. Highlights • Di-and tetranuclear copper(II) complexes have been synthesized. • The metal complexes bind to FS-DNA in non-intercalation binding mode. • Both complexes show in vitro cytotoxicity via an apoptotic cell death mechanism. Abstract New di-and tetranuclear copper(II) complexes of formula [Cu (phen) (mqpa)]·2H 2 O·CH 3 CH 2 OH (1) and [Cu 2 (phen) 2 (ppa) 2 (H 2 O) 2 ]·4H 2 O·CH 3 CH 2 OH (2) (phen = 1,10- phenanthroline, H 2 mqpa = 4-(2-methyl-quinolin-1-ium-8-yloxy) phthalic acid, H 2 ppa = 3-(pyridiium-3-yloxy) phthalic acid) have been synthesized and characterized by elemental analysis, infrared spectrum, and single X-ray diffraction. In complex 1 , two [Cu(phen)] units are bridged by two mqpa ligands via carboxyl bridges, forming a binuclear compound with Cu…Cu distance of 3.329 Å. Through strong π…π and CH…π weak interaction, complex 1 molecules are assembled into 2D supramolecular structures. Compound 2 features a metallamacrocyclic assembly in which four [Cu(phen)(H 2 O)] species are linked together by four ppa bridge ligands in head to tail fashion with Cu…Cu distance of 8.713 and 8.528 Å. The adjacent tetranuclear complex 2 molecules stacked together through strong π…π. The Cu(II) ions in two compounds are all in square pyramidal geometry. The interaction of two complexes with FS-DNA was studied by electronic absorption titration and ethidium bromide displacement experiments, the result displayed both complexes interact with DNA in non-intercalation mode, molecular docking simulation displayed that complex 1 interacts with DNA with a partial intercalation mode and complex 2 favor binding to major groove. Both complexes exhibit cytotoxicity against HeLa cells and AGZY-83a cells, and complex 2 has similar anticancer activity toward HeLa cells with cisplatin. The results of apoptosis assays by flow cytometry shows complex 2 promotes more apoptosis in HeLa cell lines than complex 1. [ABSTRACT FROM AUTHOR]

A series of novel cytotoxic compounds, [Mn(cpt)2], [Zn(tpt)(H2O)2]⋅DMA⋅2(H2O) and [Cu(tpt)]⋅DMA (cpt = 4′‐(4‐carboxyphenyl)‐2,2′:6′,2″‐terpyridine, tpt = 4‐(2,4,6‐tricarboxylphenyl)‐2,2′:6′,2″‐terpyridine, DMA = (CH3)2NH), were isolated and characterized. The structures of these complexes were characterized using single‐crystal X‐ray diffraction. The mode and extent of binding between fish sperm DNA and the complexes were investigated using fluorescence spectroscopy and molecular docking. These results indicate the ability of the complexes to bind to DNA with different binding affinities. The binding of the Zn(II) complex with DNA is stronger than that of the corresponding Cu(II) analogue, which is expected due to the z* effect and geometry. The ability of these complexes to cleave pBR322 plasmid DNA was demonstrated using gel electrophoresis assay, showing that the complexes have effective DNA cleavage activity. In addition, the cytotoxic effects of these complexes were examined on HeLa cells (human cervix epithelia carcinoma cells) in vitro. The three complexes exhibit different cytotoxic effects and decent cancer cell inhibitory rate. This means that the structures and type of metal have a great influence on the activity of these novel complexes. [ABSTRACT FROM AUTHOR]

The novel metal coordination polymer [Mn(L)2(H2O)2]n, was synthesized and characterized. Fluorescence and UV absorption spectroscopy indicates that the ligand and Mn(II) comploud can bind to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the ligand and Mn(II) complex to cleave the HL-60 plasmid DNA. Apoptotic study shows the complexes exhibited significant cancer cell (JEKO-1 and KB) inhibitory rate. The results indicate that the complexe and the ligand bound to DNA with different binding affinity, in the order the Mn(II) complex > the ligand. Oxygen and nitrogen atoms which chelated with Mn(II) forming hydrogen bonds with N6 atom of adenine and O4 atom of thymine to affect the stability of DNA from Molecular docking study. [ABSTRACT FROM AUTHOR]

Two isomeric dinuclear Cerium(II) complexes 1 and 2, formulated as Ce 2 (phen) 2 (NO 3 ) 2 (L) 4 [L = phenylacetic acid, phen = 1,10-phenanthroline] was synthesized under solvothermal conditions at different pH values. The two complexes were characterized by elemental analysis, IR and single crystal X-ray diffraction. Complexes 1 and 2 were studied the binding with DNA and against cytotoxic activity. Fluorescence analysis indicated that the two complexes can bind to DNA. The changes with different gradient concentration of DNA added into the complexes in absorption spectra show a strongπ-stacking interaction between the complexes and DNA base pairs. The Cerium(II) complexes showed good cytotoxic activity against cancer cell lines, being 2 the most potent complex. Apoptotic studies of the two novel dinuclear complexes showed significant inhibitory rate on cancer cell growth line KB. [ABSTRACT FROM AUTHOR]

Two new zinc complexes, namely Zn(L)ClCHNO(1) and {Zn(L)CHNO}▪N(CH)▪ClO(2) (L = 3,5-di(1H-imidazol-1-yl)pyridine L = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spectra, elemental analysis, and a single crystal X-ray diffraction. Fluorescence spectroscopy indicated that two complexes presented strong DNA binding affinity constants to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic study showed the complex exhibited significant cancer cell(KB) inhibitory rate. [ABSTRACT FROM AUTHOR]

A series of complexes [Pd(L1)(Phen)]·2H2O (1), [Pd(L2)(Phen)]·H2O (2), [Pd(L3)(Phen)]·H2O (3), [Pd(L4)(Phen)]·2H2O (4) and [Pd(L5)(Phen)]·2H2O (5) were prepared. The complexes were characterized by IR, 1H NMR, elemental analysis, and single-crystal X-ray diffractometry. The binding of the complexes was investigated by fluorescence spectrum and UV spectrum, showing the ability of interaction with DNA of intercalative mode. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR322 DNA. Moreover, the five complexes bind to DNA with different binding affinities, in ascending order: complex 1 < 2<3 < 4 < 5. Evaluation of cytotoxic activity of the complexes against five different cancer cell lines proved that the complexes exhibited cytotoxic specificity and significant cancer cell inhibitory rate. [ABSTRACT FROM AUTHOR]

A mononuclear complex, La(Phen)2L2(NO3) (Phen?=?1,10-phenanthroline, L?=?2-ethylphenylacetic acid), was synthesized by the reaction of La(NO3)3·H2O, Phen and L at room temperature. The central ion shows 10-coordination with two Phen and two L molecules. Elemental analysis, IR spectra, and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure. Solid fluorescence shows the luminescent properties of the complex. DNA-binding properties of the complex were examined by fluorescence spectra. The capability of cleavage of pBR322 DNA by the complex was investigated by agarose gel electrophoresis, showing cleaving efficiency. La atom allows the formation of a 10-coordinate distorted-triangle tetrakaidecahedron geometry in the complex. [ABSTRACT FROM AUTHOR]

A mixed ligand-nickel complex of formula [Ni(DBMA)(en)(H2O)3]·3H2O, where DBMA = 2,2-dibenzyl malonic acid, en = ethylenediamine, has been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The unit cell parameters for the complex area = 16.0214(16) Å,b = 10.0801(10) Å,c = 15.4024(15) Å,β = 108.488(2)°,V = 2359.074(40) Å3,Z = 4, space groupP2(1)/c. The crystal system of the complex is monoclinic. Thermal stability of the water cluster by thermogravimetric analysis has been studied. Gel electrophoresis assay demonstrated the ability of the complex to cleave pBR322 plasmid DNA. The binding of the complex with HeLa cell DNA (HC-DNA) has been investigated by fluorescence spectra. Value of IC50calculated for the complex shows that the complex exhibits good cytotoxicity against HeLa and KB cell lines. [ABSTRACT FROM AUTHOR]

To explore anti-tumor activities of manganese complexes, two complexes have been synthesized and characterized. Complex1is bridged by 1,10-phenanthroline and 2,4-biphenyl dicarboxylate. The two complexes have strong fluorescent emission and interact with DNA in an intercalative mode. The complexes also exhibit significant cytotoxic specificity and cancer cell inhibition. [ABSTRACT FROM AUTHOR]

Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)2(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells. [ABSTRACT FROM AUTHOR]

Abstract: The complex [Cu4(phen)4(H2O)2]·(pyri)·3H2O(where phen = 1,10-phenanthroline and pyri = 3,5-pyridine dicarboxylic acid)has been synthesized and characterized. IR spectra, elemental analysis and X-ray single-crystal diffraction were carried out to determine the composition and crystal structure of the complex. The binding of the complex with HC-DNA (HeLa cells DNA, which was extracted by ourselves) was investigated by fluorescence spectrum. Gel electrophoresis assay demonstrates the ability of the complex to cleave the extracted HC-DNA. Additionally, the complex exhibited a significant cytotoxic specificity and cancer cell inhibitory rate. The apoptotic tests indicate that the complex have an apoptotic effect on HeLa cells. [Copyright &y& Elsevier]

Abstract: Two novel dinuclear complexes [Co2(L)2(phen)2·2H2O]n (1), [Co2(L)2(bipy)2]n (2) (where phen=1,10-phenanthroline, bipy=2,2′-bipyridine, and L=biphenyl-2,4′-dicarboxylic acid) have been synthesized and characterized using IR, 1H NMR, element analysis and single-crystal X-ray diffractometry. The binding of the complexes with HC-DNA (HeLa cells DNA, which was extracted by ourselves) was investigated by fluorescence spectrum. The experimental results show that the two complexes have the ability to bind with extracted HC-DNA. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the extracted HC-DNA. The complexes exhibit a higher cytotoxicity against tumor cells as against normal cells in vitro. Further more, the apoptotic tests indicate that the complexes have an apoptotic effect on HeLa cells. [Copyright &y& Elsevier]

Abstract: In an attempt to establish fundamental structure–activity relationships (SAR) of Pt/Pd-based anti-tumour compounds, we have recently designed monodentate pyridyl amide ligand containing central amide units which possess external metal co-ordinating pyridyl group and internal amide functionality. It was prepared in one step from commercially available compounds in moderate to good yield. Surprisingly, treatment of K2[MCl4] [M=Pt(II), Pd(II)] with ligand N-(4-chlorophenyl)-3-pyridinecarboxamide (L) in the same reaction condition affords two different hydrogen-bonded polymers: cis-[PtL2Cl2]·CH3OH·DMF (1) and trans-[PdL2Cl2]·2DMF (2). Fluorescence analysis indicates that the two complexes can bind to fish sperm DNA (FS-DNA) and gel electrophoresis assay demonstrates the ability of the complexes to cleave the pBR322 plasmid DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, cytotoxicity values are higher in the case of cis-Pt(II) complex than trans-Pd(II) complex in four different cancer cell lines. [ABSTRACT FROM AUTHOR]

Abstract: Four novel Zn(II) complexes [Zn(L1)(bipy)(H2O)2]·4H2O(1), [Zn(L1)(phen)(H2O)2]·4H2O(2), [Zn(L2)(bipy)(H2O)2]·4H2O(3) and [Zn(L2)(phen)(H2O)2]·4H2O (4), where bipy=2,2′-bipyridine, phen=1,10-phenanthroline, L1 =2,2′-bipyridine 5,5′-dicarboxylic acid, L2 =2,2′-bipyridine-4,4′-dicarboxylic acid, have been synthesized and characterized using IR, 1H NMR, element analysis and single-crystal X-ray diffractometry. The unit cell parameters for the title complex (1), a =7.9621(10)Å, b =12.6853(17)Å, c =13.3714(17)Å, α =68.549(2)°, β=79.065(2)°, γ =88.723(2)°, V =1232.5(3)Å3, Z =15, space group,P-1(2).complex (4) a =9.5710(5)Å, b =14.1140(7)Å, c =19.0045(9)Å, α =90°, β =99.9920(10)°, γ =90°, V =2528.3(2)Å3, Z =32, space group, P121/n 1(14). The binding of the complexes with fish sperm DNA (FS-DNA) was investigated by electronic absorption spectra and fluorescence spectroscopy, showing that the complexes have the ability of interaction with DNA of intercalative mode. The intrinsic binding constant K of the complexes with FS-DNA is 0.37×105 M−1 (1) 0.73×105 M−1 (2), 0.98×105 M−1 (3), and 1.05×105 M−1 (4). The results indicate that the four complexes bound to DNA with different binding affinity, in the order complex 4 > 3 > 2 > 1. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the pBR322 plasmid DNA. The cytotoxic activity of the complexes was tested against four different cancer cell lines. The four complexes exhibited cytotoxic specificity and significant cancer cell inhibitory rate. [Copyright &y& Elsevier]

Abstract: A novel tetranuclear palladium(II) complex [Pd4(phen)4 (μ-pydc)4]·10H2O (phen = 1,10-phenanthroline, pydc = pyridine-3,4-dicarboxylate) has been synthesized and characterized. In the tetranuclear complex, two pairs of dipalladated [Pd(phen)] moieties are bridged together by four pydc, presenting a hairpin molecular shape. The binding of the title complex with fish sperm DNA (FS-DNA) has been investigated by UV spectrum and fluorescence spectrum. All the results indicate that the complex bind to DNA in an intercalative mode and considerating the molecular shape and size, the dipalladated phenanthroline moieties bisintercalate to the base pairs of DNA. Agarose gel electrophoresis assay demonstrates the ability of the complex to cleave the pBR322 plasmid DNA. Cytotoxic activity studies show the complex exhibited good cytotoxic activity against four different cancer cell lines. [Copyright &y& Elsevier]

Abstract: Two novel complexes, namely, [Pd(pdc)2]·(dmp)·6H2O (1) and [Pd(pdc)2K(H2O)5·3H2O]n (2) [H2pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesized and characterized as pH-dependent products. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Values of IC50 calculated for complexes 1 and 2 show that the two complexes exhibit good cytotoxic activity against different cell lines tested in general, especially more effective against HL-60 and A2780cisR cell lines. [Copyright &y& Elsevier]

Abstract: The complexes [Pt(dmphen)CO3]·H2O (1), [Pd(dmphen)CO3]·H2O (2) (dmphen is 2,9-dimethyl-1,10-phenanthroline) have been synthesized and characterized. The binding of the complexes with FS-DNA was investigated by UV spectrum and fluorescence spectrum, showing that the complexes have the ability of interaction with DNA of intercalative mode. The intrinsic binding constant K of the complexes with FS-DNA is 1.8×105 M−1 (1) and 1.6×104 M−1 (2), respectively. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Evaluation of cytotoxic activity of the complexes against four different cancer cell lines proved that the complexes exhibited cytotoxic specificity and significant cancer cell inhibitory rate. [Copyright &y& Elsevier]

The mononuclear palladium(II) (1) and platinum(II) (2) complexes containing phenylglycine have been synthesized and characterized by elemental analysis, IR spectra, and 1H NMR spectra. The structure of 1 was determined by X-ray diffractometry. The interaction between the complexes and fish sperm DNA (FS-DNA), adenosine-5'-triphosphate (ATP), and adenine (Ade) were investigated by UV absorption spectra, the interaction mode of the complex binding to DNA was studied by fluorescence spectra and viscometry. The results indicate that the two complexes have different binding affinities to DNA, complex 2 > complex 1. Gel electrophoresis assay demonstrates that the two complexes have the ability to cleave pBR322 plasmid DNA. Cytotoxicity experiments were carried out toward four different cancer cell lines, and 1 shows lower inhibitory efficiency than 2, consistent with the binding affinities towards DNA. [ABSTRACT FROM AUTHOR]

Abstract: The novel Pd(II) complex, [Pd2(μ-bzta)4]·1.5DMSO (where bzta=benzothiazole-2-thiolate) has been synthesized and structurally characterized by element analysis, IR and single-crystal X-ray diffractometry. In the binuclear complex, two palladium(II) are bridged by four deprotonated benzothiazole-2-thialate in a head to tail disposition and the distance of the two Pd(II) is 2.747Å. Three-dimensional structure of the complex was constructed though S⋯S (3.339Å) weak interaction and π⋯π stack. The binding of the title complex with fish sperm DNA (FS-DNA) has been investigated by absorption and fluorescence spectra. The results indicate that the complex bind to FS-DNA in an intercalative mode and the intrinsic binding constant K of the title complex with FS-DNA is about 1.2×104 M−1. Gel electrophoresis assay demonstrates the ability of the complex to cleave the pUC19 plasmid DNA. [Copyright &y& Elsevier]

Abstract: The complex [Cd2(phen)4(p-phth)(H2O)2](p-phth)·10H2O (1) has been synthesized by the reaction Cd(NO3)2 with phen and p-phth (where phen=1,10-phenanthroline, p-phth= p-phthalic acid) in a solution of ethanol and distilled water. The crystal structure was characterized by X-ray single-crystal diffraction and infrared spectrum. In 1, a novel 2D supramolecular structure was formed, containing water octamer and tetramer. [Copyright &y& Elsevier]

The complexes [Pb 4 L 4 Cl] n (1) (HL = 4′-(4-(4‑carbonylphenyl)phenyl)-2,2′:6′2″ -terpyridine) and [PbL′(NO 3)·NO 3 ] n (2) (H 2 L′ = 4′-(4-(3,5-dicarbonylphenyl)phenyl) -2,2′:6′2″-terpyridine) were synthesized and characterized by single-crystal X-ray diffraction, elemental analysis, IR sprectra and PXRD. Complex 1 is a 2D coordination polymer with one-dimensional open channels in the size of 18.35 × 18.35 Å2, while complex 2 has a coordination chain with an open channel. Both 1 and 2 can further stretched to a 3D supramolecular structure through π–π stacking interaction. The results of solid-state fluorescence spectrum at room temperature showed that complexes 1 and 2 exhibited blue light fluorescent property. They can be used as potential fluorescent materials that emit blue light. Unlabelled Image • Two lead complexes based on similar carboxylphenyl terpyridine were synthesized. • Two porous complexes exhibited 2D layer or 1D chain structure with open channel. • The work used lead of p main group metal as new-type discrete luminescence center. • The complexes have potential application as fluorescent materials with blue light. [ABSTRACT FROM AUTHOR]

Abstract: Two new complexes, [Cu(L)2(CH3COO)2(H2O)]·6H2O (1) and [Cu2(L)2(CH3COO)4]·2C2H5OH (2) (where L N-(4-chlorophenyl)-3-pyridinecarboxamide), have been synthesized by altering the solvent of reaction system. For 1, the mononuclear complex is extended into a 3D supramolecular architecture through intricate non-covalent interactions. Unexpectedly, two scarcely reported cyclic water tetramers with C2h and D2h symmetries simultaneously exist in a 1D water chain. Whereas the dinuclear complex 2 represents a 2D framework by double hydrogen bonds with solvent ethanol molecules and π–π stacking interactions. In addition, the luminescent properties of them are also discussed. [Copyright &y& Elsevier]

Two new complexes, Zn(L) 2 (H 2 O) 2 ( 1 ) and Mn(L) 2 (H 2 O) 2 ( 2 ) [L = 2-Methyl-1H-4,5-imidazoledicarboxylic acid] were synthesized and characterized by elemental analysis, infrared spectroscopy, and single crystal X-ray diffraction. Intramolecular weak interactions, such as hydrogen-bond and intermolecular interactions were presented in the complexes. The activities of the complexes binding with DNA, and cytotoxic activities were studied. The binding of complexes with fish sperm DNA (FS-DNA) was investigated by fluorescence spectra. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR322 plasmid DNA. The cytotoxic activities of the complexes were tested against the KB cell line. Cytotoxic activity studies showed the two complexes exhibited significant cancer cell inhibitory rate. The most active compound was complex 1 with IC 50 and CC 50 value of 36.5, 429, with the selectivity index (SI = 11.75) among the tested compounds. [ABSTRACT FROM AUTHOR]

Hydrothermal reaction of rare earth oxides with 1H-benzimidazole-5,6-dicarboxylic acid (H 3 bidc) and MnSO 4 ·H 2 O afforded a series of new three-dimensional (3D) coordination polymers, namely, [Ln 2 Mn(Hbidc) 2 (SO 4 ) 2 ·8H 2 O] n (Ln = Sm ( 1 ), Eu ( 2 ), Tb ( 3 ), Dy ( 4 ) and Ho ( 5 )) and [Gd 2 Mn(Hbidc) 2 (SO 4 ) 2 ·7H 2 O] n ( 6 ). Their structures have been determined by single-crystal X-ray diffraction analyses and further characterized by elemental analyses, FT-IR, powder X-ray diffraction and thermogravimetric analyses (TGA). The single-crystal X-ray diffraction analysis reveals that coordination polymers 1 – 6 have similar 3D frameworks fabricated through Hbidc 2 − and SO 4 2 − bridging dinuclear lanthanide secondary building units. Moreover, the photoluminescence of complexes 1 – 4 and magnetism of complexes 4 and 6 have been investigated, 4 exhibits remarkably slow magnetic relaxation behavior with the energy barrier Δ E / k B = 83.3 K. [ABSTRACT FROM AUTHOR]

Four novel complexes based on the ligand piperazine (Pip) in a chair conformation have been synthesized, namely [Pd(5,5′-dcbpy)Pip] ·4H2O ( 1), [Pt(5,5′-dcbpy)Pip] ·3H2O ( 2), [Pd(4,4′-dcbpy)Pip] ·4H2O ( 3), and [Pt(4,4′-dcbpy)Pip] ·2H2O ( 4; 4,4′-dcbpy = 2,2′-bipyridyl-4,4′-dicarboxylate, 5,5′-dcbpy = 2,2′-bipyridyl-5,5′-dicarboxylate). The four complexes were characterized by elemental analysis, FTIR spectroscopy, 1H and 13C NMR spectroscopy, and single-crystal X-ray diffraction analysis. In addition, gel electrophoresis was performed on the four complexes and further insight into these complexes was gained by quantum chemistry calculations. The interaction of these complexes with fish sperm DNA (FS-DNA) was studied by UV/Vis and fluorescence spectroscopy, which revealed that they have the ability to bind to FS-DNA. The IC50 values of the four complexes range from 8.3 to 32.5 μ M. Finally, we studied the cytotoxic activities of complexes 1- 4 against two different cancer cell lines. [ABSTRACT FROM AUTHOR]

A coordination polymer, [Cd(L)2(H2O)2]n(HL = 2-methyl-1H-4,5-imidazoledicarboxylic acid), was prepared from reactions of Cd(NO3)2with L at room temperature. It was characterized by IR spectra and elemental analysis. The complex was structurally characterized by X-ray single-crystal diffraction revealing that the complex crystallizes in monoclinic withP2(1)/cspace group,a = 12.203(10) Å,b = 9.332(8) Å,c = 7.554(7) Å,β = 100.894(2) Å,V = 844.7(13) Å3,Z = 2. Fluorescence and UV absorption spectroscopy indicated that the complex can bind to fish sperm DNA. Gel electrophoresis assay demonstrated the ability to cleave the HL-60 plasmid DNA. Apoptotic study showed that the complex exhibited significant cancer cell (JEKO and KB) inhibitory rate. Complex binding to DNA in an intercalative mode [ABSTRACT FROM PUBLISHER]

Abstract: Three heterometallic coordination polymers [Gd2Cu(Hbidc)2(SO4)2(H2O)7]n (1), [Eu2Cu(Hbidc)2(SO4)2(H2O)7]n (2), and [Dy2Cu(Hbidc)2(SO4)2(H2O)7]n (3) (H3bidc=1H-benzimidazole-5,6-dicarboxylic acid) have been synthesized under hydrothermal conditions. They are characterized by elemental analysis (EA), infrared (IR) spectroscopy, thermogravimetric analysis (TGA), single crystal X-ray diffraction, and power X-ray diffraction (XRD). The results reveal that all complexes present almost identical three-dimensional (3D) PtS topology framework structures. The photoluminescent properties of 2 and 3 are investigated. [Copyright &y& Elsevier]

A series of lanthanide-organic framework coordination polymers, {[La2(TDC)2(NO3)(H2O)4](OH)·5H2O}n(1) and [Ln(TDC)(NO3)(H2O)]n(TDC = thiophene- 2, 5- dicarboxylic acid; Ln = Nd(2), Sm(3), Eu(4), Gd(5), Tb(6), Dy(7), Ho(8), Er(9), Yb(10)) have been synthesized by solvothermal reaction and characterized by elemental analysis, FT-IR, TG analysis, single-crystal X-ray diffraction and power X-ray diffraction. The single-crystal X-ray diffraction analysis results show that 1displays a 3-D porous framework with (3,7)-connected {410.611}{43} topology. The compounds 2–10crystallized in the same P21/cspace group and exhibits a (3,6)-connected {4.62}2{42.610.83} topology, Right-handed and left-handed helical chains coexist in the 2-D layer structure. The luminescence properties of 2–10and the magnetic properties of 5,7,8,9were investigated. [ABSTRACT FROM AUTHOR]

Abstract: Two heterometallic coordination polymers, {KBa(ptc)(H2O)2}n(1) and {KCaEr(ptc)2(H2O)}n(2) (H3ptc=pyridine-2,4,6-tricarboxylic acid) have been synthesized under hydrothermal conditions and characterized by elemental analysis, IR and single crystal X-ray diffraction. 1 and 2 exhibit two novel three-dimensional (3D) frameworks, and the luminescence properties of 1, 2 were investigated. [Copyright &y& Elsevier]

Four complexes, [Ag4(bipy)2(Himdc)2(H2O)2]n (1), [Ag(H2imdc)]n (2), [K(H3imdc)(H2imdc)(H2O)2]n (3), and [Cu(Himc)2] (4) (H3imdc = 1H-imidazole-4,5-dicarboxylic acid, H2imc = 1H-imidazole-2-carboxylic acid, and bipy = 4,4'-bipyridine), were hydrothermally synthesized and characterized by single-crystal X-ray diffraction analysis and elemental analysis. The obtained complexes exhibit different coordination structures; 1 contains a 2-D supramolecular layer based on two chains arraying uniformly in an ABAB manner. Compound 2 displays sawtooth-shaped 1-D chains extending to 2-D layers via hydrogen bond interactions. Compound 3 possesses a 3-D framework structure based on a 1-D chain via hydrogen bonding interactions. Compound 4 has a 3-D framework structure bearing a pcu-type topology. In addition, the photoluminescence for 1 has been investigated. [ABSTRACT FROM AUTHOR]

Objective The Pd(II) complex with pyridine?2,6?dicarboxylic acid (L) has been obtained. Methods The complex was synthesized in good yields and characterized by elemental analysis and IR spectra. We analyze the ability of the complex to cleave the pBR 322 plasmid DNA, cytotoxicity and apoptotic. Results Gel electrophoresis assay demonstrates the ability of the complex to cleave the pBR 322 plasmid DNA.The complex show cytotoxic specificity and have an apoptotic effect on HeLa cells. Conclusion The complex exhibit an efficient DNA-cleavage activity, cytotoxic studies show that the title complex exhibit cytotoxic activity against different cell lines, especially more effective against KB cell lines in general test. Additionally, the apoptotic tests indicated that the complex had an apoptotic effect on HeLa cells. [ABSTRACT FROM AUTHOR]

Objective The complex Pd(dmphen)Cl2 has been synthesized( where dmphen = 2,9-dimethyl 1,10-phenanthroline),and its mode of interaction with calf thymus DNA(CT-DNA) has been discussed by spectrum method. Methods The complex Pd(dmphen)Cl2 has been synthesized under normal conditions. The binding of the complex with CT-DNA was investigated by electronic absorption spectroscopy and fluorescence spectroscopy, and its mode of interaction with CT-DNA has been discussed on the consideration of non-covalent intercalative way.Results The target complex has been successfully synthesized and characterized using element analysis and IR spectrum. The non-covalent bond involving the complex and CT-DNA results in hypochromism and red shift with the addition of CT-DNA in electronic absorption spectroscopy of the title complex. And the quenching of DNA-EtBr fluorescence by the addition of complex causes a reduction in the emission intensity, indicating the competition between the complex between EtBr in binding to DNA. Conclusion The complex exhibits certain cytotoxic activity against tumor cells and is of potential medicinal value. [ABSTRACT FROM AUTHOR]

Abstract: Three novel coordination polymers [(Eu2(Hbidc)2(ox)2·(H2O)3] (1), [Tb2(Hbidc)2(ox)(H2O)2]·4H2O (2), [Er2(Hbidc)2(ox)] (3) have been synthesized with hydrothermal reaction (H3bidc=Benzimidazole-5,6-dicarboxylic acid, H2ox=Oxalic acid) and characterized by elemental analysis, IR and X-ray single crystal diffraction. 1, 2 and 3 have the same crystal system of triclinic, but they exhibit different kinds of metal-organic framework structures. The luminescent properties of 1 and 2 were studied at room temperature. [Copyright &y& Elsevier]

Abstract: Heterometallic coordination polymers of the form {[SmMn2(imdc)2(OAc)(H2O)]·2H2O} n (1) (H3imdc=4,5-imidazoledicarboxylic acid, HOAc=acetic acid) were hydrothermally synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The results reveal that 1 has a three-dimensional framework containing Sm2Mn4 clusters. The luminescence and magnetic properties of 1 were also investigated. [Copyright &y& Elsevier]

Abstract: A novel 4d–4f heterometallic coordination polymer [EuAg(imdc)2] n (1) (imdc=imidazoledicarboxylate) has been hydrothermally synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. X-ray single-crystal structural analysis reveals that 1 is a three-dimensional framework. Furthermore, 1 also displayed photoluminescent properties in the red range at room temperature. [Copyright &y& Elsevier]

[Cd2(phen)2(DPZDA)2(H2O)2] · 8H2O (1) and [Zn(phen)(DPZDA)(H2O)] · 2H2O (2) have been synthesized by reaction of Cd(NO3)2/Zn(NO3)2 with phen and DPZDA (where phen = 1,10-phenanthroline, H2DPZDA = 3,5-dimethyl-2,6-pyrazinedicarboxylic acid) in aqueous ethanol solution. Elemental analysis, IR spectra, thermal analyses and X-ray single crystal diffraction were carried out to determine the composition and crystal structure of 1 and 2. In 1, a 2D supramolecular network containing a novel metal-water decamer were formed by hydrogen bonds. In 2, a 2D supramolecular structure was constructed from hydrogen bonds and π·· · π interactions. Moreover, 1 and 2 displayed photoluminescent properties in the blue range at room temperature. [ABSTRACT FROM AUTHOR]

The title compound, [Zn(C11H11O4)(C12H8N2)]·8H2O, was synthesized by the reaction of 1,10-phenanthroline (phen) and 2-phenethyl­malonic acid (H2pmal) with Zn(NO3)2. Two mol­ecules of phen and one H2pmal are chelated to the ZnII ion in a bidentate manner in a distorted octa­hedral geometry. The structure is stabilized by extensive C—H⋯O intra- and inter­molecular inter­actions, forming a three-dimensional network. In addition, π–π and C—H⋯π inter­actions are also present in the crystal structure. [ABSTRACT FROM AUTHOR]

Two new complexes, [Ho(L)2NO3]n (1) and [Co(L′)2Cl4]n (2) (HL = 3,5‐bis(triazol‐1‐yl)benzoic acid, HL′ = 2,4‐bis(triazol‐1‐yl)benzoic acid), have been synthesized and characterized. Interactions with DNA through absorption titration experiments, fluorescence spectra, viscosity measurements and a molecular docking study were examined. The results suggested that complexes 1 and 2 interact with DNA in a partial intercalation mode. DNA binding affinity was determined using kb values, which indicated that the binding activity of the complexes to DNA was complex 2 (kb = 1.93 × 104) > complex 1 (kb = 1.06 × 104). Gel electrophoresis assay demonstrated that the complexes have the ability to cleave pBR322 DNA. Apoptotic assay indicated that the complexes can induce programmed death of Hela cells (human cervix carcinoma cells). A cytotoxicity study indicated that complex 2 shows a greater inhibitory rate of Hela cells than complex 1 and the cytotoxicity of both 1 and 2 showed time dependence. Especially, the efficacy of complex 2 was shown to be higher than that of cisplatin at 72 h. We have synthesized and characterized complexes 1‐2, the spectroscopy methods showed that complexes 1 and 2 interaction with DNA in a partial intercalation mode and this result was further verified by docking study. The flow cytometry and morphological analysis showed that the two complexes exhibited apoptosis activity. [ABSTRACT FROM AUTHOR]