18 results on '"Giulia Montrasio"'
Search Results
2. Ring-like LGE in Advanced Friedreich's Ataxia Cardiomyopathy
- Author
-
Giulia Montrasio, MD, Marina Zaromytidou, MD, PhD, MSc, Paula Velazquez, MD, Joana Silva Ferreira, MD, Paola Giunti, and Konstantinos Savvatis, MD, PhD
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
- Full Text
- View/download PDF
Catalog
3. Infiltrative Disease Presenting with an Inflamed Heart
- Author
-
Paula Poveda Velazquez, Giulia Montrasio, MD, Marina Zaromytidou, MD, PhD, MSc, Massimiliano Lorenzini, PhD, Saidi Mohiddin, and Neha Sekhri
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
- Full Text
- View/download PDF
4. Sex differences of vascular brain lesions in patients with atrial fibrillation
- Author
-
Christian Müller, Leo H Bonati, Pascal Meyre, Steffen Blum, Stefanie Aeschbacher, David Conen, Stefan Osswald, Urs Fischer, Manuel R Blum, Simon Jung, Jens Wuerfel, Christian Sticherling, Michael Kuhne, Philipp Krisai, Matthias Schwenkglenks, Luise Adam, Elisavet Moutzouri, Martin Feller, Nathalie Schwab, Claudio Schneider, Drahomir Aujesky, Nicolas Rodondi, Karl-Olof Lovblad, Michael Amann, Richard Kobza, Marie Méan, Andreas Müller, Giorgio Moschovitis, Fabienne Witassek, Silke Küest, Sonja Meier, Jürg-Hans Beer, Damiana Rakovic, Michael Coslovsky, Tiziano Moccetti, Ramun Schmid, Augusto Gallino, Carole Elodie Aubert, Georg Ehret, Angelo Auricchio, Giulio Conte, Daniel Hayoz, Benjamin Berte, Nathalie Lauriers, Peter Ammann, François Regoli, Dipen Shah, Laurent Roten, Marco Düring, Pascal Benkert, Simone Evers-Dörpfeld, Elisa Hennings, Ceylan Eken, Selinda Ceylan, Anne Springer, Heinrich Mattle, Tim Sinnecker, Leo Bonati, Anna Altermatt, Manuel Blum, Sacha Niederberger, Chloé Auberson, Simone Evers-Doerpfeld, Marc Girod, Elena Herber, Vasco Iten, Mirko Lischer, Christine Meyer-Zürn, Andreas U Monsch, Thomas Szucs, Gian Völlmin, Juerg Fuhrer, Axel Loewe, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Simone Fontana, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Adriana Anesini, Cristina Camporini, Maria Luce Caputo, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Luisa Vicari, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Patrick Perret, Philippe Tavel, Cheryl Teres, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Jane Frangi-Kultalahti, Marcello Di Valentino, Jens Würfel, Petra Huber, Esther Ruberte, Vanessa Zuber, Gilles Dutilh, Milica Markovic, Pia Neuschwander, and Patrick Simon more...
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective To examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF).Methods In this cross-sectional analysis, we included 1743 patients with AF (27% women) from the multicentre Swiss Atrial Fibrillation study (SWISS-AF) with available baseline brain MRI. We compared presence and total volume of large non-cortical or cortical infarcts (LNCCIs), small non-cortical infarcts, microbleeds (MB) and white matter hyperintensities (WMH, Fazekas score ≥2 for moderate or severe degree) between men and women with multivariable logistic regression. We generated voxel-based probability maps to assess the anatomical distribution of lesions.Results We found no strong evidence for an association of female sex with the prevalence of all ischaemic infarcts (LNCCI and SNCI combined; adjusted OR 0.86, 95% CI 0.67 to 1.09, p=0.22), MB (adjusted OR 0.91, 95% CI 0.68 to 1.21, p=0.52) and moderate or severe WMH (adjusted OR 1.15, 95% CI 0.90 to 1.48, p=0.27). However, total WMH volume was 17% larger among women than men (multivariable adjusted multiplicative effect 1.17, 95% CI 1.01 to 1.35; p=0.04). Lesion probability maps showed a right hemispheric preponderance of ischaemic infarcts in both men and women, while WMH were distributed symmetrically.Conclusion Women had higher white matter disease burden than men, while volume and prevalence of other lesions did not differ. Our findings highlight the importance of controlling risk factors for cerebral small vessel disease in patients with AF, especially among women. more...
- Published
- 2022
- Full Text
- View/download PDF
5. Multimodality Imaging in Sarcomeric Hypertrophic Cardiomyopathy: Get It Right…on Time
- Author
-
Alessandro Galluzzo, Francesca Fiorelli, Valentina A. Rossi, Luca Monzo, Giulia Montrasio, Massimiliano Camilli, Geza Halasz, Giuseppe Uccello, Rocco Mollace, and Matteo Beltrami
- Subjects
hypertrophic cardiomyopathy ,phenocopies ,left ventricular systolic dysfunction ,left ventricular diastolic dysfunction ,outcome ,imaging ,Science - Abstract
Hypertrophic cardiomyopathy (HCM) follows highly variable paradigms and disease-specific patterns of progression towards heart failure, arrhythmias and sudden cardiac death. Therefore, a generalized standard approach, shared with other cardiomyopathies, can be misleading in this setting. A multimodality imaging approach facilitates differential diagnosis of phenocopies and improves clinical and therapeutic management of the disease. However, only a profound knowledge of the progression patterns, including clinical features and imaging data, enables an appropriate use of all these resources in clinical practice. Combinations of various imaging tools and novel techniques of artificial intelligence have a potentially relevant role in diagnosis, clinical management and definition of prognosis. Nonetheless, several barriers persist such as unclear appropriate timing of imaging or universal standardization of measures and normal reference limits. This review provides an overview of the current knowledge on multimodality imaging and potentialities of novel tools, including artificial intelligence, in the management of patients with sarcomeric HCM, highlighting the importance of specific “red alerts” to understand the phenotype–genotype linkage. more...
- Published
- 2023
- Full Text
- View/download PDF
6. PO-04-015 BIVENTRICULAR ARRHYTHMOGENIC CARDIOMYOPATHY ASSOCIATED WITH A NOVEL HETEROZYGOUS PLAKOPHILIN-2 EARLY TRUNCATING VARIANT
- Author
-
Tolga C¸imen, Verena C. Wilzeck, Giulia Montrasio, Nicole R. Bonetti, Argelia Medeiros-Domingo, Christian Grebmer, Christian M. Matter, Felix C. Tanner, Robert Manka, Corinna B. Brunckhorst, Firat Duru, and Ardan Saguner more...
- Subjects
Physiology (medical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
- Full Text
- View/download PDF
7. Prevalence and risk of inappropriate dosing of direct oral anticoagulants in two Swiss atrial fibrillation registries
- Author
-
Giulia Montrasio, Martin F. Reiner, Andrea Wiencierz, Stefanie Aeschbacher, Christine Baumgartner, Nicolas Rodondi, Michael Kühne, Giorgio Moschovitis, Helga Preiss, Michael Coslovsky, Maria L. De Perna, Leo H. Bonati, David Conen, Stefan Osswald, Juerg H. Beer, Pascal Koepfli, University of Zurich, and Montrasio, Giulia more...
- Subjects
Pharmacology ,Physiology ,Administration, Oral ,Anticoagulants ,Hemorrhage ,610 Medicine & health ,1314 Physiology ,Brain Ischemia ,Stroke ,3004 Pharmacology ,Fibrinolytic Agents ,1313 Molecular Medicine ,Atrial Fibrillation ,Prevalence ,10209 Clinic for Cardiology ,Molecular Medicine ,Humans ,Female ,Prospective Studies ,Registries ,360 Social problems & social services ,Switzerland - Abstract
BACKGROUND Direct oral anticoagulants (DOACs) have a favourable risk-benefit profile compared to vitamin K-antagonists (VKAs) in atrial fibrillation (AF). Dosing is based on age, weight and renal function, without need of routine monitoring. METHODS AND RESULTS In two prospective, multicentre AF cohorts (Swiss-AF, BEAT-AF) patients were stratified as receiving VKAs or adequately-, under- or overdosed DOACs, according to label. Primary outcome was a composite of major adverse clinical events (MACE), defined as cardiovascular death, myocardial infarction (MI), ischaemic stroke and systemic embolism. Secondary outcomes included major bleeding. Adjustment for confounding was performed. Median follow-up was 4 years. Of 3236 patients, 1875 (58%) were on VKAs and 1361 (42%) were on DOACs, of which 1137 (83%) were adequately-, 134 (10%) over- and 90 (7%) under-dosed. Compared to adequately dosed individuals, overdosed patients were more likely to be older and female. Underdosing correlated with concomitant aspirin therapy and coronary artery disease. Both groups had higher CHA2DS2-VASc scores. Patients on overdosed DOACs had higher incidence of MACE (HR 1.75; CI 1.10-2.79; adjusted-HR: 1.22) and major bleeding (HR 1.99; CI 1.14-3.48; adjusted-HR: 1.51). Underdosing was not associated with a higher incidence of MACE (HR 0.94; CI 0.46-1.92; adjusted-HR 0.61) or major bleeding (HR 1.07; CI 0.46-2.46; adjusted-HR 0.82). After adjustment, all CIs crossed 1.0. CONCLUSION Inappropriate DOAC-dosing was more prevalent in multimorbid patients, but did not correlate with higher risks of adverse events after adjusting for confounders. DOAC prescription should follow label. more...
- Published
- 2022
- Full Text
- View/download PDF
8. Fulminant Cardiotoxicity in a Patient With Cardiac Lymphoma Treated With CAR-T Cells
- Author
-
Christian Koch, Giulia Montrasio, Benedikt Florian Scherr, Roman Schimmer, Christian M. Matter, Karl Philipp Bühler, Markus G. Manz, Antonia M.S. Müller, University of Zurich, and Müller, Antonia M S
- Subjects
Oncology ,10209 Clinic for Cardiology ,610 Medicine & health ,2730 Oncology ,Cardiology and Cardiovascular Medicine ,2705 Cardiology and Cardiovascular Medicine - Published
- 2022
- Full Text
- View/download PDF
9. Biventricular Arrhythmogenic Cardiomyopathy Associated with a Novel Heterozygous
- Author
-
Tolga, Çimen, Verena C, Wilzeck, Giulia, Montrasio, Nicole R, Bonetti, Argelia, Medeiros-Domingo, Christian, Grebmer, Christian M, Matter, Felix C, Tanner, Robert, Manka, Corinna B, Brunckhorst, Firat, Duru, and Ardan M, Saguner more...
- Abstract
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a hereditary condition that can cause sudden cardiac death in young, frequently athletic individuals under the age of 35 due to malignant arrhythmias. Competitive and endurance exercise may hasten the onset and progression of ARVC, leading to right ventricular dysfunction and potentially fatal ventricular arrhythmias earlier in life. In this article, we present a novel, pathogenic, early truncating heterozygous variant in the more...
- Published
- 2022
10. Oral Flucloxacillin for Treating Osteomyelitis: A Narrative Review of Clinical Practice
- Author
-
Andréea Anamaria Moldovan, Ilker Uçkay, Giulia Montrasio, Benjamin A. Lipsky, Philipp Kriechling, İmke Janssen, Helga Preiss, and Tanja Huber
- Subjects
0301 basic medicine ,medicine.medical_specialty ,literature review ,medicine.drug_class ,030106 microbiology ,Antibiotics ,Review ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Orthopedic surgery ,Oral route ,Medicine ,oral flucloxacillin ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Adverse effect ,Intensive care medicine ,clinical remission ,business.industry ,Osteomyelitis ,osteomyelitis ,medicine.disease ,Clinical Practice ,stomatognathic diseases ,lcsh:RD701-811 ,Infectious Diseases ,Antibiotic Agents ,clinical treatment ,Surgery ,Narrative review ,Flucloxacillin ,business ,medicine.drug - Abstract
Flucloxacillin (FLU) administered by the oral route is widely used for treating various infections, but there are no published retrospective or prospective trials of its efficacy, or its advantages or disadvantages compared to parenteral treatment or other antibiotics for treating osteomyelitis. Based on published in vitro data and expert opinions, other non-β-lactam oral antibiotics that have better bone penetration are generally preferred over oral FLU. We reviewed the literature for studies of oral FLU as therapy of osteomyelitis (OM), stratified by acute versus chronic and pediatric versus adult cases. In striking contrast to the prevailing opinions and the few descriptive data available, we found that treatment of OM with oral FLU does not appear to be associated with more clinical failures compared to other oral antibiotic agents. Because of its narrow antibiotic spectrum, infrequent severe adverse effects, and low cost, oral FLU is widely used in clinical practice. We therefore call for investigators to conduct prospective trials investigating the effectiveness and potential advantages of oral FLU for treating OM. more...
- Published
- 2020
11. The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation
- Author
-
Mark G Filipovic, Giulia Montrasio, Stefan Osswald, Michael Coslovsky, Giorgio Moschovitis, Pascal Meyre, Andrea Wiencierz, Oliver Baretella, Nicolas Rodondi, David Conen, Giovanni G. Camici, Stefanie Aeschbacher, Philipp Baumgartner, Martin F Reiner, Leo H. Bonati, Michael Kühne, Thomas F. Lüscher, Nicole R. Bonetti, Jürg H. Beer, University of Zurich, and Beer, Jürg H more...
- Subjects
Male ,eicosapentaenoic acid ,030204 cardiovascular system & hematology ,Gastroenterology ,11459 Center for Molecular Cardiology ,Brain ischemia ,chemistry.chemical_compound ,0302 clinical medicine ,atrial fibrillation ,Stroke ,Aged, 80 and over ,Nutrition and Dietetics ,omega-3 fatty acids ,Brain ,Atrial fibrillation ,Middle Aged ,Magnetic Resonance Imaging ,Eicosapentaenoic acid ,stroke ,3. Good health ,Docosahexaenoic acid ,cardiovascular system ,2916 Nutrition and Dietetics ,lipids (amino acids, peptides, and proteins) ,Female ,Docosapentaenoic acid ,lcsh:Nutrition. Foods and food supply ,Brain Infarction ,medicine.medical_specialty ,610 Medicine & health ,lcsh:TX341-641 ,Article ,03 medical and health sciences ,360 Social problems & social services ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Omega 3 fatty acid ,1106 Food Science ,Aged ,business.industry ,Odds ratio ,medicine.disease ,brain ischemia ,10040 Clinic for Neurology ,Cross-Sectional Studies ,chemistry ,570 Life sciences ,biology ,business ,030217 neurology & neurosurgery ,Food Science - Abstract
The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and alpha-linolenic acid (ALA) were determined by gas chromatography in 1657 AF patients from the Swiss Atrial Fibrillation study. All patients underwent brain MRI to detect ischemic brain infarcts, classified as large noncortical or cortical infarcts (LNCCIs), markers of small vessel disease, classified as small noncortical infarcts (SNCIs), number of microbleeds, and white matter lesion (WML) volumes. Individual and total n-3 FAs (EPA + DHA + DPA + ALA) were correlated with LNCCIs and SNCIs using logistic regression, with numbers of microbleeds using a hurdle model, and WML volumes using linear regression. LNCCIs were detected in 372 patients (22.5%). EPA correlated inversely with the prevalence of LNCCIs (odds ratio [OR] 0.51 per increase of 1 percentage point EPA, 95% confidence interval [CI] 0.29–0.90). DPA correlated with a higher LNCCI prevalence (OR 2.48, 95%CI 1.49–4.13). No associations with LNCCIs were found for DHA, ALA, and total n-3 FAs. Neither individual nor total n-3 FAs correlated with markers of small vessel disease. In conclusion, EPA correlates inversely with the prevalence of ischemic brain infarcts, but not with markers of small vessel disease in patients with AF. more...
- Published
- 2021
- Full Text
- View/download PDF
12. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation
- Author
-
Steffen Blum, Stefanie Aeschbacher, Pascal Meyre, Michael Kühne, Nicolas Rodondi, Jürg H. Beer, Peter Ammann, Giorgio Moschovitis, Leo H. Bonati, Manuel R. Blum, Peter Kastner, Fiona Baguley, Christian Sticherling, Stefan Osswald, David Conen, Chloé Auberson, Leo Bonati, Selinda Ceylan, Simone Doerpfeld, Ceylan Eken, Marc Girod, Peter Hämmerle, Philipp Krisai, Christine Meyer-Zürn, Andreas U. Monsch, Christian Müller, Anne Springer, Thomas Szucs, Gian Voellmin, Leon Zwimpfer, Drahomir Aujesky, Urs Fischer, Juerg Fuhrer, Laurent Roten, Simon Jung, Heinrich Mattle, Luise Adam, Carole Elodie Aubert, Martin Feller, Axel Loewe, Elisavet Moutzouri, Claudio Schneider, Tanja Flückiger, Cindy Groen, Lukas Ehrsam, Sven Hellrigl, Alexandra Nuoffer, Damiana Rakovic, Nathalie Schwab, Rylana Wenger, Christopher Beynon, Roger Dillier, Michèle Deubelbeiss, Franz Eberli, Christine Franzini, Isabel Juchli, Claudia Liedtke, Jacqueline Nadler, Thayze Obst, Jasmin Roth, Fiona Schlomowitsch, Xiaoye Schneider, Katrin Studerus, Noreen Tynan, Dominik Weishaupt, Andreas Müller, Simone Fontana, Silke Kuest, Karin Scheuch, Denise Hischier, Nicole Bonetti, Alexandra Grau, Jonas Villinger, Eva Laube, Philipp Baumgartner, Mark Filipovic, Marcel Frick, Giulia Montrasio, Stefanie Leuenberger, Franziska Rutz, Jürg-Hans Beer, Angelo Auricchio, Adriana Anesini, Cristina Camporini, Giulio Conte, Maria Luce Caputo, Francois Regoli, Tiziano Moccetti, Roman Brenner, David Altmann, Michaela Gemperle, Mathieu Firmann, Sandrine Foucras, Martine Rime, Daniel Hayoz, Benjamin Berte, Virgina Justi, Frauke Kellner-Weldon, Brigitta Mehmann, Sonja Meier, Myriam Roth, Andrea Ruckli-Kaeppeli, Ian Russi, Kai Schmidt, Mabelle Young, Melanie Zbinden, Richard Kobza, Jane Frangi-Kultalahti, Anica Pin, Luisa Vicari, Georg Ehret, Hervé Gallet, Elise Guillermet, Francois Lazeyras, Karl-Olof Lovblad, Patrick Perret, Philippe Tavel, Cheryl Teres, Dipen Shah, Nathalie Lauriers, Marie Méan, Sandrine Salzmann, Jürg Schläpfer, Andrea Grêt, Jan Novak, Sandra Vitelli, Frank-Peter Stephan, Augusto Gallino, Marcello Di Valentino, Fabienne Witassek, Matthias Schwenkglenks, Jens Würfel, Anna Altermatt, Michael Amann, Petra Huber, Esther Ruberte, Tim Sinnecker, Vanessa Zuber, Michael Coslovsky, Pascal Benkert, Gilles Dutilh, Milica Markovic, Patrick Simon, Ramun Schmid, Clinical sciences, Auberson, Chloé, Bonati, Leo, Ceylan, Selinda, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Meyer-Zürn, Christine, Monsch, Andreas U., Müller, Christian, Springer, Anne, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Ehret, Georg Benedikt, Gallet, Hervé, Guillermet, Elise, Lazeyras, François, Lövblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres Castillo, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, and Schmid, Ramun more...
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Epidemiology ,Heart failure ,030204 cardiovascular system & hematology ,ddc:616.0757 ,03 medical and health sciences ,0302 clinical medicine ,Insulin-Like Growth Factor Binding Proteins/blood ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,Clinical endpoint ,Natriuretic peptide ,medicine ,Heart Failure/blood ,Humans ,030212 general & internal medicine ,cardiovascular diseases ,Hospitalization/statistics & numerical data ,Aged ,Retrospective Studies ,ddc:616 ,Heart Failure ,Proportional hazards model ,business.industry ,Insulin-like growth factor-binding protein 7 ,Hazard ratio ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Prognosis ,Confidence interval ,Hospitalization ,Insulin-Like Growth Factor Binding Proteins ,Atrial Fibrillation/blood ,Cardiology ,Disease Progression ,Female ,business ,Cardiology and Cardiovascular Medicine ,Biomarkers/blood ,Biomarkers ,Cohort study ,Follow-Up Studies - Abstract
BACKGROUND: The occurrence of congestive heart failure (CHF) hospitalization among patients with atrial fibrillation (AF) is a poor prognostic marker. OBJECTIVE: The purpose of this study was to assess whether insulin-like growth factor-binding protein 7 (IGFBP-7), a marker of myocardial damage, identifies AF patients at high risk for this complication. METHODS: We analyzed 2 prospective multicenter observational cohort studies that included 3691 AF patients. Levels of IGFBP-7 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured from frozen plasma samples at baseline. The primary endpoint was hospitalization for CHF. Multivariable adjusted Cox regression analyses were constructed. RESULTS: Mean patient age was 69 ± 12 years, 1028 (28%) were female, and 879 (24%) had a history of CHF. The incidence per 1000 patient-years across increasing IGFBP-7 quartiles was 7, 10, 32, and 85. The corresponding multivariable adjusted hazard ratios (aHRs) (95% confidence interval [CI]) were 1.0, 1.05 (0.63-1.77), 2.38 (1.50-3.79), and 4.37 (2.72-7.04) (P for trend more...
- Published
- 2020
13. Current trends in dual antiplatelet therapy: a 2017 update
- Author
-
Luigi Biasco, Giulia Montrasio, Marco Moccetti, Giovanni Pedrazzini, and University of Zurich
- Subjects
animal structures ,business.industry ,Electronic engineering ,Medicine ,610 Medicine & health ,DUAL (cognitive architecture) ,Current (fluid) ,Cardiology and Cardiovascular Medicine ,business ,11171 Cardiocentro Ticino - Published
- 2017
- Full Text
- View/download PDF
14. Evaluation of a protocol for same-day discharge after radial lounge monitoring in a southern Swiss referral percutaneous coronary intervention centre
- Author
-
Giovanni Pedrazzini, Marco Araco, Daniele Del Monte, Martina Boscolo Berto, Tiziano Moccetti, Fulvio Bomio, Giulia Montrasio, Daniel Sürder, Elena Pasotti, Francesco Petracca, Marco Moccetti, Alessandro Del Bufalo, Luigi Biasco, University of Zurich, and Biasco, Luigi more...
- Subjects
Coronary angiography ,Male ,medicine.medical_specialty ,Time Factors ,Referral ,medicine.medical_treatment ,610 Medicine & health ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,11171 Cardiocentro Ticino ,2705 Cardiology and Cardiovascular Medicine ,03 medical and health sciences ,Patient safety ,0302 clinical medicine ,Patient satisfaction ,Percutaneous Coronary Intervention ,medicine ,Humans ,030212 general & internal medicine ,Same day discharge ,Aged ,Retrospective Studies ,business.industry ,Percutaneous coronary intervention ,Retrospective cohort study ,General Medicine ,Middle Aged ,Patient Discharge ,Surgery ,Patient Satisfaction ,Conventional PCI ,Emergency medicine ,Female ,Patient Safety ,Cardiology and Cardiovascular Medicine ,business ,Switzerland - Abstract
The aim of the study was to retrospectively evaluate safety and patient satisfaction of same-day discharge after elective radial coronary angiography/percutaneous coronary intervention (PCI) after the implementation of a radial lounge facility.All patients admitted to our radial lounge with a planned same-day discharge after an uncomplicated coronary angiography/PCI, having a co-living caregiver, were day enrolled in the study. Rates of same-day discharge, unplanned overnight stay, and in-hospital and first complications [death, myocardial infarction (MI), unplanned coronary angiography, access site hematoma, bleedings requiring hospitalization] were analysed; satisfaction was also evaluated through a questionnaire.From February 2015 to January 2016, 312 patients with a mean age of 66.6 ± 10.8 years were admitted to the radial lounge (coronary angiography, n = 232; PCIs, n = 80). Of them, 245 (78.5%) were discharged the same day. Mean radial lounge monitoring was 6:35 h (interquartile range 5:30-7:30 h). No episodes of death/MI/unplanned coronary angiography were observed both in same-day discharged and postponed patients. Reasons to postpone discharge were: PCI deemed to need prolonged monitoring in 31, patient's preference in 14, femoral shift in 13, surgery in four, chest pain in four, and bleeding in one. At day 1, 11 access site hematoma and one hospitalization for access site bleeding were reported. Patients reported complete satisfaction in 97% of cases. Unplanned overnight stay was common among PCIs patients (RR 6.2, 95% CI 3.9-9.9, P 0.001).A low rate of minor complications was observed in elective radial coronary angiography and PCIs showing the feasibility and safety of the development of an institutional protocol for same-day discharge after the implementation of a radial lounge facility. more...
- Published
- 2017
15. TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population
- Author
-
Raffaella Cinquetti, D Simmen, Paola Campomenosi, Giulia Montrasio, Giorgio Binelli, Sarah Grossi, Paolo Castelnuovo, and Stefania Gallo
- Subjects
0301 basic medicine ,Male ,Disease ,Pathogenesis ,Gastroenterology ,Receptors, G-Protein-Coupled ,0302 clinical medicine ,Genotype ,Nasal polyps ,Genetics(clinical) ,Prospective Studies ,030223 otorhinolaryngology ,Sinusitis ,Genetics (clinical) ,Rhinitis ,Bitter taste receptor T2R38 ,respiratory system ,Middle Aged ,Chronic rhinosinusitis ,Genotyping ,TAS2R38 gene ,TAS2R38 ,Italy ,Female ,Research Article ,Adult ,Natural Orifice Endoscopic Surgery ,medicine.medical_specialty ,animal structures ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,White People ,03 medical and health sciences ,Nasal Polyps ,Internal medicine ,medicine ,Genetics ,otorhinolaryngologic diseases ,Humans ,Genetic Predisposition to Disease ,Allele ,Aged ,Case-control study ,medicine.disease ,030104 developmental biology ,Case-Control Studies ,Immunology ,Gene-Environment Interaction - Abstract
Background Chronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms within the TAS2R38 gene have been implicated as possible contributors to the complex gene-environment interactions in CRS. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype, CRS and related comorbidities. Methods Fifty-three CRS patients and 39 healthy individuals were genotyped at the TAS2R38 locus. CRS patients were treated by endoscopic sinus surgery and medical therapies and subdivided in CRS with nasal polyps (CRSwNPs) and CRS without nasal polyps (CRSsNPs). The effect of genotype on CRS and CRS-related comorbidities was assessed. Results The distribution of the different genotypes at the TAS2R38 locus was not significantly different between CRS patients, either with or without nasal polyps, and controls. Besides, no association was found between the different genotypes at the TAS2R38 locus and CRS-related comorbidities. Conclusions No association was found between TAS2R38 alleles or genotypes and CRS, thus questioning its role in the pathogenesis of CRS. Electronic supplementary material The online version of this article (doi:10.1186/s12881-016-0321-3) contains supplementary material, which is available to authorized users. more...
- Published
- 2016
16. Analysis of mucociliar clearance: a new diagnostic method and a therapeutical proposal
- Author
-
Alberto Macchi, Giulia Montrasio, and Stefania Gallo
- Subjects
Pulmonary and Respiratory Medicine ,Nasal cavity ,Pathology ,medicine.medical_specialty ,business.industry ,Mucociliary clearance ,Immunology ,Mucous membrane of nose ,Inflammation ,Paranasal sinuses ,medicine.anatomical_structure ,Immune system ,Poster Presentation ,medicine ,Immunology and Allergy ,medicine.symptom ,business ,Nose ,Respiratory tract - Abstract
Mucociliary clearance is a key defence mechanism in human upper and lower airways and its impairment predisposes to chronic infections of the nose, paranasal sinuses and respiratory tract. Nasal mucociliary clearance is a first-line physiological function of nasal cavity, that helps protecting the lower respiratory tract from undesirable organic and inorganic matter, including microorganisms. On one hand, multiple investigations have demonstrated a marked decrease in nasal mucociliary clearance in patients with rhinitis or chronic rhinosinusitis. Ciliary motility analysis allows us to have an index of our defense mechanisms functionality and of our ability to react to microorganisms. The ciliary motility can be evaluated with a light microscope using phase contrast. Sampling should be performed through a brushing at the level of the middle third of the inferior turbinate and the sample must be analyzed immediately after collection. Through the analysis of the sample, it is possible to evaluate the presence of ciliated cells with a functional edge, to calculate the length of the ciliary motilia, to assess the direction of movement and to evaluate the coordination of the lashes. The time needed for this examination is short, it only takes 5 to 10 minutes, and it appears to be not invasive, repeatable and not painful. The ciliary function may also be influenced by the use of certain medications, such as anti-histamines, whereas it may be stimulated and improved by the use of topical hyaluronic acid. HA may be an important regulator of the inflammatory process. During nasal inflammation, high-molecular weight HA breaks down under the influence of free radicals and enzymes. Low-molecular weight fragments deliver signals regarding tissue damage and mobilize immune cells, while the high molecular weight form suppresses immune cells function and prevents excessive exacerbation of inflammation. Based on the known background of the effects of HA in the regulation of vasomotor tone, mucous gland secretion and in the modulation of the inflammatory process, it is suggested that HA may improve ciliary motility, nasal mucosa cellularity and inflammatory status. more...
- Published
- 2015
- Full Text
- View/download PDF
17. TAS2R38 taste receptor gene and chronic rhinosinusitis: a bitter ending
- Author
-
Giorgio Binelli, Giulia Montrasio, Stefania Gallo, D Simmen, Paolo Castelnuovo, Paola Campomenosi, Raffaella Cinquetti, and Sarah Grossi
- Subjects
Pulmonary and Respiratory Medicine ,Innate immune system ,business.industry ,Immunology ,Single-nucleotide polymorphism ,Disease ,Bioinformatics ,Pathogenesis ,TAS2R38 ,Taste receptor ,Poster Presentation ,Genotype ,otorhinolaryngologic diseases ,Immunology and Allergy ,Medicine ,Allele ,business - Abstract
Background Chronic rhinosinusitis (CRS) is a frequent disease with a high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms (SNPs) within the TAS2R38 gene were pointed at as possible contributors to the complex gene-environment interactions in CRS. This hypothesis was supported by in vitro evidence of the protective effect exerted by the functional bitter taste receptor T2R38 on sinonasal mucosa, due to its role in innate immunity. The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype and CRS comorbidities and to assess whether the presence of a particular allele can be considered a prognostic marker. more...
- Published
- 2015
- Full Text
- View/download PDF
18. Nasal citology: a new diagnostic approach in rhinology
- Author
-
Alberto Macchi, Paola Terranova, Giulia Montrasio, Matteo Gelardi, and Eleonora Sica
- Subjects
Pulmonary and Respiratory Medicine ,Rhinology ,medicine.medical_specialty ,Pathology ,Allergy ,business.industry ,Immunology ,Inflammation ,respiratory system ,medicine.disease ,Mast cell ,Infectious Rhinitis ,medicine.anatomical_structure ,Eosinophilic ,Poster Presentation ,medicine ,Immunology and Allergy ,Eosinophilia ,medicine.symptom ,business ,Asthma - Abstract
Nasal cytology is a diagnostic method in the field rinology used to detect changes into the endonasal epithelium exposed to physical and/or chemical irritation, acute or chronic inflammation due to different angents (viral, bacterial, fungal or parasitic). Nasal cytology was born in 1889 thanks to H. Gollash who found many eosinophilic cells into the nasal secretions of a patient affected by asthma, and thought of them as important elements in the pathogenesis of this disease. The main evolution of nasal cytology occurred in 1927, thanks to the report done by C. Eyermann, who noted the presence of eosinophilic cells into the nasal secretions of allergic patients. Since then great importance is given to the recognition of specific cell types into the pathogenesis of different nasal diseases. Nasal cytology is nowadays more frequently used in the study of allergic, vasomotor, inflammatory and infectious rhinitis. It is a simple, non-invasive and repeatable examination which is useful in the follow-up and monitoring of the real effectiveness of medical and surgical treatments. Patients affected by allergic rhinitis (AR) develop an endonasal immediate response, so-called “early phase”, followed by a “late phase” response to the allergenic agent. From the microscopic point of view, both these responses are always characterized by an infiltration of the mucosa by immunoflogistic cells (eosinophils, mast cells, neutrophils and lymphocytes) that, following the release of several chemical mediators, are the main cause of the symptoms that characterize the IgE-mediated disease. In AR the main cells type released during the immunological response will change depending on whether the patient is examined during or outside the pollinic season. In the first condition, the patient will present all the clinical signs and his nasal cytology examination will be characterized by neutrophils, lymphocytes, eosinophils and mast cells largely degranulated. Nasal cytology allows us to differentiate between various forms of rhinitis which are resumed as: non-allergic rhinitis with neutrophil (Narne); non-allergic rhinitis with eosinophilia (NARES); non-allergic rhinitis with mast cells (NARMA); non-allergic eosino. more...
- Published
- 2015
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.