8,838 results on '"Jun Luo"'
Search Results
2. Genome-wide association study provided insights into the polled phenotype and polled intersex syndrome (PIS) in goats
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Fuhong Zhang, Qingqing Liu, Ping Gong, Yaling Wang, Chenbo Shi, Lu Zhu, Jianqing Zhao, Weiwei Yao, and Jun Luo
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Goat ,Whole-genome sequencing ,GWAS ,Horn ,SNP ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background Breeding polled goats is a welfare-friendly approach for horn removal in comparison to invasive methods. To gain a comprehensive understanding of the genetic basis underlying polledness in goats, we conducted whole-genome sequencing of 106 Xinong Saanen dairy goats, including 33 horned individuals, 70 polled individuals, and 3 polled intersexuality syndrome (PIS) individuals. Methods The present study employed a genome-wide association study (GWAS) and linkage disequilibrium (LD) analysis to precisely map the genetic locus underlying the polled phenotype in goats. Results The analysis conducted in our study revealed a total of 320 genome-wide significant single nucleotide polymorphisms (SNPs) associated with the horned/polled phenotype in goats. These SNPs exhibited two distinct peaks on chromosome 1, spanning from 128,817,052 to 133,005,441 bp and from 150,336,143 to 150,808,639 bp. The present study identified three genome-wide significant SNPs, namely Chr1:129789816, Chr1:129791507, and Chr1:129791577, as potential markers of PIS-affected goats. The results of our LD analysis suggested a potential association between MRPS22 and infertile intersex individuals, as well as a potential association between ERG and the polled trait in goats. Conclusion We have successfully identified three marker SNPs closely linked to PIS, as well as several candidate genes associated with the polled trait in goats. These results may contribute to the development of SNP chips for early prediction of PIS in goats, thereby facilitating breeding programs aimed at producing fertile herds with polled traits.
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- 2024
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3. Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathway
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Qu Yang, Qi Chen, Sihui Li, and Jun Luo
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Diabetic cardiomyopathy ,Mesenchymal stem cell therapy ,Pyroptosis ,Inflammation ,microRNA ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Diabetic cardiomyopathy (DCM) stands as the primary cause of heart failure and mortality among patients with diabetes. Nevertheless, conventional treatment approaches are limited in their ability to effectively prevent myocardial tissue damage itself. Mesenchymal stem cell (MSC) therapy exhibits immense potential for treating DCM; however, the precise mechanisms involved in regulating inflammatory responses and pyroptosis processes, an emerging form of cellular death, within myocardial cells remain elusive. Hence, it is imperative to further elucidate the precise underlying mechanisms to facilitate the clinical implementation of MSC therapy. Methods In vivo, we established a DCM mouse model by administering streptozotocin and fed the mice a high-glucose and high-fat diet, followed by MSC therapy. Cardiac function and myocardial injury were evaluated through echocardiography and histological analysis. Furthermore, the levels of inflammation and pyroptosis were assessed using ELISA, Western blotting, and qRT-PCR. In vitro experiments involved inducing H9C2 myocardial cell damage with high glucose treatment, followed by coculture with MSCs to investigate their role in modulating inflammation and pyroptosis mechanisms. Results MSCs can maintain cardiac function and alleviate myocardial injury in mice with DCM. Moreover, they effectively suppress the activation of NLRP3 and reduce the release of inflammatory factors (such as IL-1β and ROS), thereby further downregulating the expression of pyroptosis-related proteins including NLRP3, Caspase-1, and GSDMD. Additionally, we experimentally validated that MSCs exert their therapeutic effects by promoting the expression of miR-223-3p in cardiac myocytes; however, this effect can be reversed by an miR-223-3p inhibitor. Conclusion MSCs effectively mitigate the release of inflammatory factors and cell lysis caused by pyroptosis through the regulation of the miR-223-3p/NLRP3 pathway, thereby safeguarding cardiomyocytes against damage in DCM. This mechanism establishes a novel theoretical foundation for the clinical treatment of cardiac conditions utilizing MSCs.
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- 2024
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4. Adaptive Memetic Algorithm with Dual-Level Local Search for Cooperative Route Planning of Multi-Robot Surveillance Systems
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Hao Cheng, Jin Yi, Wei Xia, Huayan Pu, and Jun Luo
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multi-robot system ,surveillance ,memetic algorithm ,Electronic computers. Computer science ,QA75.5-76.95 ,Systems engineering ,TA168 - Abstract
The heightened autonomy and robust adaptability inherent in a multi-robot system have proven pivotal in disaster search and rescue, agricultural irrigation, and environmental monitoring. This study addresses the coordination of multiple robots for the surveillance of various key target positions within an area. This involves the allocation of target positions among robots and the concurrent planning of routes for each robot. To tackle these challenges, we formulate a unified optimization model addressing both target allocation and route planning. Subsequently, we introduce an adaptive memetic algorithm featuring dual-level local search strategies. This algorithm operates independently among and within robots to effectively solve the optimization problem associated with surveillance. The proposed method’s efficacy is substantiated through comparative numerical experiments and simulated experiments involving diverse scales of robot teams and different target positions.
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- 2024
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5. BaCe0.8Fe0.1Ni0.1O3−δ-impregnated Ni–GDC by phase-inversion as an anode of solid oxide fuel cells with on-cell dry methane reforming
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Yanya Liu, Jun Luo, Cheng Li, Bo Liu, Dong Yan, Jian Li, and Lichao Jia
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solid oxide fuel cells (sofcs) ,phase-inversion ,aerogel ,dry reforming of methane (drm) ,carbon resistance ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
BaCe0.8Fe0.1Ni0.1O3−δ (BCFN) in a perovskite structure is impregnated consecutively by BCFN solution and BCFN suspension into a phase-inversion prepared NiO–Gd0.1Ce0.9O2−δ (GDC) scaffold as an anode for solid oxide fuel cells (SOFCs) with on-cell dry reforming of methane (DRM). The whole pore surface of the scaffold is covered by small BCFN particles formed by BCFN solution impregnation; the large pores near the scaffold surface are filled by BCFN aerogels with a high specific surface area produced by BCFN suspension impregnation, which act as a catalytic layer for on-cell DRM. After reduction, the anode consists of a Ni–GDC scaffold and BCFN particles with exsolved FeNi3 nanoparticles. This BCFN-impregnated Ni–GDC anode has higher electrical conductivity, electrochemical activity, and resistance to carbon deposition, with which the cell shows maximum power densities between 1.44 and 0.92 W·cm−2 when using H2 and between 1.09 and 0.50 W·cm−2 when using CO2–CH4 at temperatures ranging from 750 to 600 °C. A stable performance at 400 mA·cm−2 and 700 °C is achieved using 45% CO2–45% CH4–10% N2 for more than 400 h without carbon deposition, benefiting from the impregnated BCFN aerogel with a high specific surface area and water adsorbability.
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- 2024
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6. Comparative efficacy of zero-profile implant and conventional cage-plate implant in the treatment of single-level degenerative cervical spondylosis: a systematic review and meta-analysis
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Peng Zhang, Hongyu Zheng, Jun Luo, and Jie Xu
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Anterior cervical decompression and fusion ,Zero-profile ,Cage plate ,Single level ,Meta-analysis ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background In recent years, the zero-profile implant (Zero-p) has emerged as a promising internal fixation technique. Although studies have indicated its potential superiority over conventional cage-plate implant (Cage-plate) in the treatment of degenerative cervical spondylosis, there remains a lack of definitive comparative reports regarding its indications, safety, and efficacy. Methods A computerized search was conducted on English and Chinese databases, including PubMed, Web of Science, Cochrane Library, EMBASE, CNKI, Wanfang and VIP. Additionally, a manual search was meticulously carried out on Chinese medical journals, spanning from the inception of the respective databases until August 2023. The meta-analysis utilized a case–control study approach and was executed through the utilization of RevMan 5.3 software. Stringent quality evaluation and data extraction procedures were implemented to guarantee the reliability and validity of the findings. Results Nine high-quality studies with 808 patients were included. Meta-analysis showed that the operation time (MD = − 13.28; 95% CI (− 17.53, − 9.04), P
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- 2024
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7. Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
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Zhi-Jian Zhu, Man Teng, Yu Liu, Fu-Jia Chen, Yongxiu Yao, En-Zhong Li, and Jun Luo
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Immunologic diseases. Allergy ,RC581-607 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry. The onset of MD lymphomas and other clinical diseases can be efficiently prevented by vaccination; these vaccines are heralded as the first demonstration of a successful vaccination strategy against a cancer. However, the persistent evolution of epidemic MDV strains towards greater virulence has recently resulted in frequent outbreaks of MD in vaccinated chicken flocks worldwide. Herein, we provide an overall review focusing on the discovery and identification of the strategies by which MDV evades host immunity and attacks the immune system. We have also highlighted the decrease in the immune efficacy of current MD vaccines. The prospects, strategies and new techniques for the development of efficient MD vaccines, together with the possibilities of antiviral therapy in MD, are also discussed.
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- 2024
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8. Transcriptomic profiling and gene network analysis revealed regulatory mechanisms of bract development in Bougainvillea glabra
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Xiangdong Liu, Yaonan Peng, Qinghui Zeng, Yuwan Ma, Jin Liu, Yaqi Huang, Xiaoying Yu, Jun Luo, Yanlin Li, Meng Li, and Fuxiang Cao
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Bract development ,Bougainvillea glabra ,MADS-box ,Squamosa promoter binding protein (SBP) ,Plant hormone signal transduction ,Chlorophyll metabolic pathways ,Botany ,QK1-989 - Abstract
Abstract Background Bracts are important for ornamental plants, and their developmental regulation process is complex; however, relatively little research has been conducted on bracts. In this study, physiological, biochemical and morphological changes in Bougainvillea glabra leaves, leaf buds and bracts during seven developmental periods were systematically investigated. Moreover, transcriptomic data of B. glabra bracts were obtained using PacBio and Illumina sequencing technologies, and key genes regulating their development were screened. Results Scanning electron microscopy revealed that the bracts develop via a process involving regression of hairs and a color change from green to white. Transcriptome sequencing revealed 79,130,973 bp of transcript sequences and 45,788 transcripts. Differential gene expression analysis revealed 50 expression patterns across seven developmental periods, with significant variability in transcription factors such as BgAP1, BgFULL, BgCMB1, BgSPL16, BgSPL8, BgDEFA, BgEIL1, and BgBH305. KEGG and GO analyses of growth and development showed the involvement of chlorophyll metabolism and hormone-related metabolic pathways. The chlorophyll metabolism genes included BgPORA, BgSGR, BgPPH, BgPAO and BgRCCR. The growth hormone and abscisic acid signaling pathways involved 44 and 23 homologous genes, and coexpression network analyses revealed that the screened genes BgAPRR5 and BgEXLA1 are involved in the regulation of bract development. Conclusions These findings improve the understanding of the molecular mechanism of plant bract development and provide important guidance for the molecular regulation and genetic improvement of the growth and development of ornamental plants, mainly ornamental bracts.
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- 2024
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9. Modelling and analysis of the intersecting axis permanent magnet eddy‐current coupler
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Jun Luo, Yuanxin Liu, Huayan Pu, Shujin Yuan, Lei Hou, Chunlin Zhang, Jin Yi, Yi Qin, and Xiaoxu Huang
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eddy currents ,electromagnetic coupling ,magnetic forces ,permanent magnet machines ,variable speed drives ,Applications of electric power ,TK4001-4102 - Abstract
Abstract The permanent magnet eddy‐current coupler (PMEC) is a kind of non‐contact, stepless speed regulation device and has been widely used in transmissions. However, the current PMECs are coaxial and cannot achieve transmission and speed regulation in intersecting axes. An intersecting‐axis permanent magnet (PM) eddy current coupler (IPMEC), which consists of a disk‐type PM rotor and a barrel‐type conductive sheet (CS) rotor arranged with intersecting axes, is proposed. It generates eddy currents through the speed difference between the two rotors and uses the non‐contact electromagnetic force between the eddy currents and permanent magnets to transmit torque. During operation, the speed can be adjusted by altering the coupling area or air gap. A theoretical model of the IPMEC based on the equivalent magnetic circuit method is presented and verified by finite element simulation using ANSYS. Then, the effects of the pole number of the PMs, the radius of the CS rotor and the PM rotor on the performance were analysed, and the design method of the IPMEC was proposed. This study can be used to expand the application range of PMECs.
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- 2024
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10. The cross-sectional correlation between the oxidative balance score and cardiometabolic risk factors and its potential correlation with longitudinal mortality in patients with cardiometabolic risk factors
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Qiancheng Lai, Liu Ye, Jun Luo, Cheng Zhang, Qingchen Wu, and Yue Shao
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Cardiometabolic risk factors ,Mortality ,NHANES ,Oxidative balance score ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background This study analyzes the correlation between oxidative balance score (OBS), cardiometabolic risk factors (CMRFs), and mortality in individuals with CMRFs. Methods Data were chosen from the National Health and Nutrition Examination Survey. The survey-weighted multivariable logistic regression models were implemented to explore the relationship between OBS and the risk of CMRFs. Then, Cox proportional hazard models were employed to estimate the impact of OBS on mortality in individuals with CMRFs. Results Following multivariate adjustment, the subjects in the highest quartile exhibited a 46% reduction in the risk of CMRFs, a 33% reduction in the risk of diabetes, a 31% reduction in the risk of hypertension, and a 36% reduction in the risk of hyperlipidemia, compared with those in the lowest quartile. Furthermore, each 1-unit increase in OBS was remarkably negatively correlated with the prevalence of CMRFs, diabetes, hypertension, and hyperlipidemia. The correlation between OBS and CMFRs was found to be mediated by serum γ-glutamyltransferase (GGT) and white blood cells (WBC), and the mediation effect of GGT levels and WBC, accounting for 6.90% and 11.51%, respectively. Lastly, the multivariate Cox regression model revealed that elevated OBS, irrespective of whether it was treated as a categorical or continuous variable, exhibited a significant association with decreased mortality from all causes, cardiovascular disease, and cancer. Conclusions An increased OBS might reflect a lower risk of CMRFs and a favorable prognosis for individuals with CMRFs. Moreover, WBC and GGT may play a potential mediating role between OBS and CMRFs.
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- 2024
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11. A novel anti-loosening bolt looseness diagnosis of bolt connections using a vision-based technique
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Jun Luo, Kaili Li, ChengQian Xie, Zhitao Yan, Feng Li, Xiaogang Jia, and Yuanlai Wang
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Bolt connections ,Anti-loosening bolts ,Looseness detection ,Vision-based technique ,Hexagonal border reconstruction ,Medicine ,Science - Abstract
Abstract Bolt looseness detection is a common problem in engineering. Most vision-based detection techniques focus on diagnosing ordinary bolt looseness, i.e., the methods used for diagnosis are based only on the sidelines of nuts. These methods cannot be used for anti-loosening bolt looseness diagnosis because of the simultaneous rotation of screws and nuts. Therefore, a novel anti-loosening bolt looseness diagnosis method based on a vision-based technique is proposed in this paper. First, a regular hexagonal cap was installed on the screw, which can be used as a reference for the nut. Then, to automatically distinguish the hexagonal borders of the screw cap and nut, a new hexagonal border reconstruction algorithm is proposed. Furthermore, the relative rotation angles of the screw cap and nut hexagons can be determined using the sidelines of the reconstructed hexagonal borders of the screw cap and nut. Finally, a novel anti-loosening bolt looseness diagnosis method is established by using the relative rotation angle of the regular hexagonal borders of the screw cap and nut under initial status and loose status. A prototype flange node of the transmission tower was used for experimental verification. The results show that the proposed method can effectively detect the loosening angle of anti-loosening bolts.
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- 2024
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12. Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS
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Pei Yu, Yubao Han, Lulu Meng, Yanyuan Tian, Zhiwei Jin, Jun Luo, Chao Han, Wenjun Xu, Lingyi Kong, and Chao Zhang
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Lung–bone transmission ,miR-194/215 cluster ,Exosome ,Lung metastasis ,Epithelial–mesenchymal transition ,Vasculogenic mimicry ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Osteosarcoma, a prevalent primary malignant bone tumor, often presents with lung metastases, severely impacting patient survival rates. Extracellular vesicles, particularly exosomes, play a pivotal role in the formation and progression of osteosarcoma-related pulmonary lesions. However, the communication between primary osteosarcoma and exosome-mediated pulmonary lesions remains obscure, with the potential impact of pulmonary metastatic foci on osteosarcoma progression largely unknown. This study unveils an innovative mechanism by which exosomes originating from osteosarcoma pulmonary metastatic sites transport the miR-194/215 cluster to the primary tumor site. This transportation enhances lung metastatic capability by downregulating myristoylated alanine-rich C-kinase substrate (MARCKS) expression. Addressing this phenomenon, in this study we employ cationic bovine serum albumin (CBSA) to form nanoparticles (CBSA-anta-194/215) via electrostatic interaction with antagomir-miR-194/215. These nanoparticles are loaded into nucleic acid-depleted exosomal membrane vesicles (anta-194/215@Exo) targeting osteosarcoma lung metastatic sites. Intervention with bioengineered exosome mimetics (anta-194/215@Exo) not only impedes osteosarcoma progression but also significantly prolongs the lifespan of tumor-bearing mice. These findings suggest that pulmonary metastatic foci-derived exosomes initiate primary osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS, making the miR-194/215 cluster a promising therapeutic target for inhibiting the progression of patients with osteosarcoma lung metastases.
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- 2024
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13. Comparison of the Medium‐term Outcomes of Anterior Lumbar Discectomy and Fusion with Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Retrospective Cohort Study
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Chao Song, Zhibo Deng, Hanhao Dai, Wu Zheng, Guoyu Yu, Yijing Wu, Jun Luo, and Jie Xu
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Anterior lumbar discectomy and fusion ,LDDs ,Microscope ,Minimally invasive transforaminal lumbar interbody fusion ,Orthopedic surgery ,RD701-811 - Abstract
Objective Lumbar degenerative diseases (LDDs) with huge herniation in the left lateral recess or central canal present challenges for oblique lateral lumbar interbody fusion (OLIF) or endoscope‐assisted OLIF procedures. Currently, minimally invasive transforaminal lumbar interbody fusion (MIS‐TLIF) is the primary approach for this issue. This study aims to provide a standardized technical description of the anterior lumbar discectomy and fusion (ALDF) and evaluate the medium‐term clinical effectiveness of both ALDF and MIS‐TLIF techniques. Methods A retrospective review was performed on LDDs who underwent ALDF and MIS‐TLIF surgery from January 2018 to January 2020. The evaluation encompassed various clinical outcomes, such as the visual analogue scale (VAS) scores for back pain and leg pain (VAS‐back, VAS‐leg), the Oswestry disability index (ODI), the 36‐item short‐form health survey mental component summary (SF‐36 MCS), and the physical component summary (SF‐36 PCS). Additionally, radiological parameters, including disc height (DH), segmental disk angle (SDA), lumbar lordosis (LL), and cross‐sectional area (CSA), were assessed. Data including radiculopathy, estimated blood loss, operation time, time of getting out of bed, fusion rate, and complications were recorded. Student's independent samples t test and Pearson's chi‐square test were used to compare the differences between groups. Results In total, 47 patients were treated by ALDF and 48 patients were treated by MIS‐TLIF. The ALDF group exhibited statistically significant lower estimated blood loss and earlier time of getting out of bed compared to the MIS‐TLIF group (p 0.05). Conclusion The ALDF could be considered as a viable surgical alternative for the treatment of LDDs that necessitate ventral neural direct decompression. ALDF exhibited favorable medium‐term outcomes in patients with LDDs, displaying advantages in facilitating expedited recovery, enhancing radiographic outcomes, and elevating the remission rate of low back pain. Although ALDF presents slightly higher complication rates compared to MIS‐TLIF, it does not adversely affect clinical outcomes.
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- 2024
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14. The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
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Pei Yu, Yubao Han, Lulu Meng, Zengying Tang, Zhiwei Jin, Zhenzhen Zhang, Yunjiang Zhou, Jun Luo, Jianguang Luo, Chao Han, Chao Zhang, and Lingyi Kong
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the common site of metastasis. The pulmonary microenvironment plays a pivotal role in the colonization of disseminated tumor cells. Herein, this study highlights the crucial role of exosomal LAP-TGF-β1, the principal form of exosomal TGF-β1, in reshaping the pulmonary vascular niche, thereby facilitating TNBC lung metastasis. Although various strategies have been developed to block TGF-β signaling and have advanced clinically, their significant side effects have limited their therapeutic application. This study demonstrates that in lung metastatic sites, LAP-TGF-β1 within exosomes can remarkably reconfigure the pulmonary vascular niche at lower doses, bolstering the extravasation and colonization of TNBC cells in the lungs. Mechanistically, under the aegis of the acetyltransferase TIP60, a non-canonical KFERQ-like sequence in LAP-TGF-β1 undergoes acetylation at the K304 site, promoting its interaction with HSP90A and subsequent transport into exosomes. Concurrent inhibition of both HSP90A and TIP60 significantly diminishes the exosomal burden of LAP-TGF-β1, presenting a promising therapeutic avenue for TNBC lung metastasis. This study not only offers fresh insights into the molecular underpinnings of TNBC lung metastasis but also lays a foundation for innovative therapeutic strategies.
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- 2024
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15. Coexistence of pulmonary arterial hypertension and straight back syndrome in a patient with a novel BMPR2 variant affecting cytoplasmic tail domain
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Mi Tang, Jun Luo, Qingqing Liu, and Jie Song
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Pulmonary arterial hypertension ,Straight back syndrome ,BMPR2 ,Genetic variation ,Cytoplasmic tail ,Medicine - Abstract
Abstract Background Pathologic variants in the bone morphogenetic protein receptor-2 (BMPR2) gene cause a pulmonary arterial hypertension phenotype in an autosomal-dominant pattern with incomplete penetrance. Straight back syndrome is one of the causes of pseudo-heart diseases. To date, no cases of idiopathic or heritable pulmonary arterial hypertension with straight back syndrome have been reported. Case presentation A 30-year-old female was diagnosed with pulmonary arterial hypertension by right heart catheterization. Computed tomography revealed a decreased anteroposterior thoracic space with heart compression, indicating a straight back syndrome. Genetic analysis by whole exome sequencing identified a novel c.2423_2424delGT (p.G808Gfs*4) germline frameshift variant within BMPR2 affecting the cytoplasmic tail domain. Conclusions This is the first report of different straight back characteristics in heritable pulmonary arterial hypertension with a novel germline BMPR2 variant. This finding may provide a new perspective on the variable penetrance of the pulmonary arterial hypertension phenotype.
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- 2024
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16. Endoscopic Arthroplasty via Mini‐open Direct Anterior Approach Improves Postoperative Complications and Acetabular Components of Total Hip Arthroplasty in Obese Patients
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Hanhao Dai, Zhibo Deng, Linhai Yang, Chao Song, Guoyu Yu, Jun Luo, and Jie Xu
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Complications ,Direct anterior approach (DAA) ,Endoscopy ,Obesity ,Total hip arthroplasty (THA) ,Orthopedic surgery ,RD701-811 - Abstract
To overcome the high‐risk complications and poor alignment of acetabular components in obese patients associated with direct anterior approach (DAA) for total hip arthroplasty (THA), we innovated an endoscopic arthroplasty via mini‐open direct anterior approach technique (Endo‐DAA). The purpose of this study was to compare the clinical and radiographic outcomes in obese patients subjected to THA between Endo‐DAA, Bikini DAA, and conventional DAA. In this retrospective controlled study, a total of 360 consecutive primary THA on obese patients (body mass index greater than 28 kg/m2) via Endo‐DAA, Bikini DAA, and conventional DAA performed from October 2017 to October 2022 by different surgeons and in a single center were included. Assessments including perioperative parameters, clinical outcomes, complications, and radiologic measurements were retrieved from patients before the surgery, perioperative period and the latest follow‐up. A total of 360 consecutive THA (Endo‐DAA = 108, Bikini DAA = 116, Conventional DAA = 136) with complete follow‐up data were analyzed. Compared to Bikini DAA or conventional DAA, Endo‐DAA significantly shortened the length of incision (5.46 ± 0.53), the duration of operation (64.47 ± 12.38), and postoperative hospital stay (2.15 ± 0.89). Endo‐DAA significantly reduces wound related complications compared with conventional DAA. Besides, Endo‐DAA achieved a significantly better alignment of acetabular components compared to Bikini DAA or conventional DAA. Furthermore, Endo‐DAA improved postoperative pain at the activity at 24 h postoperatively and early functional scores. The Endo‐DAA THA technique provides better short‐term clinical and radiographic results in obese patients with a low rate of postoperative complications compared to Bikini DAA or conventional DAA.
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- 2024
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17. Comparison of different machine learning classification models for predicting deep vein thrombosis in lower extremity fractures
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Conghui Wei, Jialiang Wang, Pengfei Yu, Ang Li, Ziying Xiong, Zhen Yuan, Lingling Yu, and Jun Luo
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Deep vein thrombosis ,Lower extremity fractures ,Machine learning ,Prediction model ,Medicine ,Science - Abstract
Abstract Deep vein thrombosis (DVT) is a common complication in patients with lower extremity fractures. Once it occurs, it will seriously affect the quality of life and postoperative recovery of patients. Therefore, early prediction and prevention of DVT can effectively improve the prognosis of patients. This study constructed different machine learning models to explore their effectiveness in predicting DVT. Five prediction models were applied to the study, including Extreme Gradient Boosting (XGBoost) model, Logistic Regression (LR) model, RandomForest (RF) model, Multilayer Perceptron (MLP) model, and Support Vector Machine (SVM) model. Afterwards, the performance of the obtained prediction models was evaluated by area under the curve (AUC), accuracy, sensitivity, specificity, F1 score, and Kappa. The prediction performances of the models based on machine learning are as follows: XGBoost model (AUC = 0.979, accuracy = 0.931), LR model (AUC = 0.821, accuracy = 0.758), RF model (AUC = 0.970, accuracy = 0.921), MLP model (AUC = 0.830, accuracy = 0.756), SVM model (AUC = 0.713, accuracy = 0.661). On our data set, the XGBoost model has the best performance. However, the model still needs external verification research before clinical application.
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- 2024
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18. Dynamic chloride ion adsorption on single iridium atom boosts seawater oxidation catalysis
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Xinxuan Duan, Qihao Sha, Pengsong Li, Tianshui Li, Guotao Yang, Wei Liu, Ende Yu, Daojin Zhou, Jinjie Fang, Wenxing Chen, Yizhen Chen, Lirong Zheng, Jiangwen Liao, Zeyu Wang, Yaping Li, Hongbin Yang, Guoxin Zhang, Zhongbin Zhuang, Sung-Fu Hung, Changfei Jing, Jun Luo, Lu Bai, Juncai Dong, Hai Xiao, Wen Liu, Yun Kuang, Bin Liu, and Xiaoming Sun
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Science - Abstract
Abstract Seawater electrolysis offers a renewable, scalable, and economic means for green hydrogen production. However, anode corrosion by Cl- pose great challenges for its commercialization. Herein, different from conventional catalysts designed to repel Cl- adsorption, we develop an atomic Ir catalyst on cobalt iron layered double hydroxide (Ir/CoFe-LDH) to tailor Cl- adsorption and modulate the electronic structure of the Ir active center, thereby establishing a unique Ir-OH/Cl coordination for alkaline seawater electrolysis. Operando characterizations and theoretical calculations unveil the pivotal role of this coordination state to lower OER activation energy by a factor of 1.93. The Ir/CoFe-LDH exhibits a remarkable oxygen evolution reaction activity (202 mV overpotential and TOF = 7.46 O2 s−1) in 6 M NaOH+2.8 M NaCl, superior over Cl--free 6 M NaOH electrolyte (236 mV overpotential and TOF = 1.05 O2 s−1), with 100% catalytic selectivity and stability at high current densities (400-800 mA cm−2) for more than 1,000 h.
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- 2024
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19. Successful treatment for an adult with bilateral posterior teeth crossbite by miniscrew‐assisted rapid palatal expansion: A case report
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Yuan Fan, Yuanyuan Li, Manlin Fan, Yanfang Lin, Jiarong Xu, Zhihua Li, and Jun Luo
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adults ,diagnosis ,miniscrew ,rapid palatal expansion ,Medicine ,Medicine (General) ,R5-920 - Abstract
Key Clinical Message Successful treatment by miniscrew‐assisted rapid expansion and clinical aligner therapy for an adult diagnosed with maxillary transverse deficiency (MTD) by clinical examinations and Yonsei transverse analysis. Abstract Adult orthodontic diagnosis and treatment with maxillary transverse deficiency (MTD) is challenging. Miniscrew‐assisted rapid palatal expansion (MARPE) is a fast and low‐risk method to expand the width of maxillary basal bone. This case report describes a 23‐year‐old female with mandible deviation and bilateral posterior teeth crossbite. She was diagnosed as MTD by the clinical examinations and Yonsei transverse analysis, and treated by the MARPE and clinical aligner therapy. After 26 months' treatment, cone‐beam computed tomography (CBCT) images showed that the width of maxillary basal bone increased by 3.8 mm, that of zygomatic arch and nasal bone increased by 1.0 and 1.9 mm, respectively, and the bilateral posterior teeth crossbite was corrected. Furthermore, the dental midline of lower arch was consistent with that of upper arch and face, the molars arrived Angle Class II and canines was Class I relationships, the profile was maintained, the facial asymmetry was improved. The results of seventeen‐month follow‐up showed that the effect of orthodontic treatment is very stable. This case report demonstrates that MARPE is the effective approach for patients with MTD and facial asymmetry, which provide the alternative for the treatment of similar cases.
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- 2024
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20. Biomimetic Hydrogel‐Mediated Mechano‐Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery
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Yunze Dong, Jun Luo, Mingliang Pei, Shuai Liu, Yuchen Gao, Hongmin Zhou, Yimingniyizi Nueraihemaiti, Xiangcheng Zhan, Tiancheng Xie, Xudong Yao, Xin Guan, and Yunfei Xu
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clear cell renal cell carcinoma ,immunometabolic therapy ,indoleamine 2,3‐dioxygenase 1 ,tumor physical microenvironment ,tumor recurrence ,Science - Abstract
Abstract The unique physical tumor microenvironment (TME) and aberrant immune metabolic status are two obstacles that must be overcome in cancer immunotherapy to improve clinical outcomes. Here, an in situ mechano‐immunometabolic therapy involving the injection of a biomimetic hydrogel is presented with sequential release of the anti‐fibrotic agent pirfenidone, which softens the stiff extracellular matrix, and small interfering RNA IDO1, which disrupts kynurenine‐mediated immunosuppressive metabolic pathways, together with the multi‐kinase inhibitor sorafenib, which induces immunogenic cell death. This combination synergistically augmented tumor immunogenicity and induced anti‐tumor immunity. In mouse models of clear cell renal cell carcinoma, a single‐dose peritumoral injection of a biomimetic hydrogel facilitated the perioperative TME toward a more immunostimulatory landscape, which prevented tumor relapse post‐surgery and prolonged mouse survival. Additionally, the systemic anti‐tumor surveillance effect induced by local treatment decreased lung metastasis by inhibiting epithelial‐mesenchymal transition conversion. The versatile localized mechano‐immunometabolic therapy can serve as a universal strategy for conferring efficient tumoricidal immunity in “cold” tumor postoperative interventions.
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- 2024
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21. Lymphocyte to C-reactive protein ratio is associated with in-hospital cardiac death in elderly patients with non-ST-segment elevation myocardial infarction
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Jun Luo, Han Shao, Yu Song, and Yali Chao
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lymphocyte to C-reactive protein ratio ,inflammation response ,non-ST-segment elevation myocardial infarction ,in-hospital cardiac death ,elderly patients ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundAlthough percutaneous coronary intervention (PCI) is recommended by guidelines, data from the real world suggest that elderly non-ST-segment elevation myocardial infarction (NSTEMI) patients have a low rate of PCI and a high death rate. Lymphocyte to C-reactive protein ratio (LCR), a novel inflammatory marker, has been shown to be associated with prognosis in a variety of diseases. However, the relationship between LCR and in-hospital cardiac death in elderly NSTEMI patients is unclear. The aim of this study was to investigate the effect of LCR on in-hospital cardiac death in elderly NSTEMI patients without PCI therapy.MethodsThis was a single-center retrospective observational study, consecutively enrolled elderly (≥75 years) patients diagnosed with NSTEMI and without PCI from February 2019 to February 2024. LCR was defined as lymphocyte count to C-reactive protein ratio. The endpoint of observation was in-hospital cardiac death. The predictive efficacy of the old and new models was evaluated by the net reclassification index (NRI) and the integrated discriminant improvement index (IDI).ResultsA total of 506 patients were enrolled in this study, and in-hospital cardiac death occurred in 54 patients (10.7%). Univariate logistic regression analysis showed that left ventricular ejection fraction, LCR, Killip ≥2, and N-terminal B-type natriuretic peptide proteins (NT-proBNP) were associated with the occurrence of in-hospital cardiac death. After adjusting for potential confounders, the results showed that NT-proBNP (OR = 1.695, 95% CI: 1.238–2.322) and LCR (OR = 0.262, 95% CI: 0.072–0.959) were independent risk factors for in-hospital cardiac death. After the addition of LCR to NT-proBNP, the predictive ability of the new model for in-hospital cardiac death was significantly improved (NRI = 0.278, P = 0.030; IDI = 0.017, P
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- 2024
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22. Multi‐Channel Wireless Communication Based on Amplitude‐Phase Reconfigurable Space‐Coding Beamforming Metasurface
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Qi Xiong, Zuojun Zhang, Xiaoliang Ma, Cheng Huang, Mingbo Pu, Jun Luo, Yinghui Guo, Yanxun Wang, WenLin Bai, Jia Ye, Lianshan Yan, and Xiangang Luo
- Subjects
amplitude‐phase reconfigurable metasurface ,beamforming ,multi‐channel wireless communication ,space coding ,Electric apparatus and materials. Electric circuits. Electric networks ,TK452-454.4 ,Physics ,QC1-999 - Abstract
Abstract Reconfigurable metasurfaces have exhibited significant potential in wireless communication owing to their capacity to transmit information without relying on traditional complex radio frequency (RF) chain transmitters. Nonetheless, the majority of metasurface‐based wireless communication systems modulate signals only in the time domain. Here, an amplitude‐phase reconfigurable metasurface is proposed to establish a wireless communication system that can simultaneously transmit different messages to users by encoding digital signals within the spatial domain. By changing the bias voltages of varactors integrated in the meta‐atom, the reconfigurable metasurface can achieve independent 3‐bit phase and 1‐bit amplitude coding. Through a beamforming methodology, the proposed metasurface generates diverse scattering beams with suppressed sidelobe levels, which not only enables multiple channels through space coding but also reduces signal leakage in undesired directions. Numerical simulations and experiments are carried out to verify the beamforming scheme, and a dual‐channel wireless communication system is established. The results show that two distinct images can be simultaneously retrieved by two separate users, which demonstrates the dual‐channel transmission capability of the wireless communication system. The proposed strategy opens up an avenue for implementing multi‐channel wireless communication systems, which indicates its great potential in multiple‐user collaborative wireless communication and radar systems.
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- 2024
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23. Photoacoustic Imaging‐Guided Self‐Adaptive Hyperthermia Supramolecular Cascade Nano‐Reactor for Diabetic Periodontal Bone Regeneration
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Miao Zhang, Xu Peng, Hong Xu, Xiaoning Sun, Yizhu Liu, Qian Li, Yuan Ding, Shaopei Ding, Jun Luo, Jing Xie, and Jianshu Li
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diabetes mellitus ,hyperthermia ,periodontal bone regeneration ,photoacoustic imaging ,supramolecular cascade nano‐reactor ,Science - Abstract
Abstract Commencing with the breakdown of the diabetic osteoimmune microenvironment, multiple pathogenic factors, including hyperglycemia, inflammation, hypoxia, and deleterious cytokines, are conjointly involved in the progression of diabetic periodontal bone regeneration. Based on the challenge of periodontal bone regeneration treatment and the absence of real‐time feedback of blood oxygen fluctuation in diabetes mellitus, a novel self‐adaptive hyperthermia supramolecular cascade nano‐reactor ACFDG is constructed via one‐step supramolecular self‐assembly strategy to address multiple factors in diabetic periodontal bone regeneration. Hyperthermia supramolecular ACFDG possesses high photothermal conversion efficiency (32.1%), and it can effectively inhibit the vicious cycle of ROS‐inflammatory cascade through catalytic cascade reactions, up‐regulate the expression of heat shock proteins (HSPs) under near‐infrared (NIR) irradiation, which promotes periodontal bone regeneration. Remarkably, ACFDG can provide real‐time non‐invasive diagnosis of blood oxygen changes during periodontal bone regeneration through photoacoustic (PA) imaging, thus can timely monitor periodontal hypoxia status. In conclusion, this multifunctional supramolecular nano‐reactor combined with PA imaging for real‐time efficacy monitoring provides important insights into the biological mechanisms of diabetic periodontal bone regeneration and potential clinical theranostics.
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- 2024
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24. Whole-genome resequencing of native and imported dairy goat identifies genes associated with productivity and immunity
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Jianqing Zhao, Yuanpan Mu, Ping Gong, Baolong Liu, Fuhong Zhang, Lu Zhu, Chenbo Shi, Xuefeng Lv, and Jun Luo
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dairy goat ,whole-genome sequence ,genetic diversity ,selective signal ,production traits ,Veterinary medicine ,SF600-1100 - Abstract
Understanding the differences in genetic variation between local Chinese dairy goat breeds and imported breeds can help germplasm innovation and molecular breeding. However, the research is limited in this area. In this study, whole-genome resequencing data from 134 individuals of both local and imported dairy goat breeds were analyzed, and their differences in genomic genetic variation, genetic diversity, and population structure were subsequently identified. We also screened candidate genes associated with important traits of dairy goats such as milk production (STK3, GHR, PRELID3B), reproduction (ATP5E), growth and development (CTSZ, GHR), and immune function (CTSZ, NELFCD). Furthermore, we examined allele frequency distributions for the genes of interest and found significant differences between the two populations. This study provides valuable resources for the study of genetic diversity in dairy goats and lays the foundation for the selective breeding of dairy goats in the future.
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- 2024
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25. Autophagy, apoptosis, and inflammation response of Sebastiscus marmoratus to different concentrations of hydroxychloroquine
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Yifan Liu, Jun Luo, Chuanchen Ren, Long Chen, Yifeng Zhao, Xiaolong Yin, and Bingjian Liu
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hydroxychloroquine (HCQ) ,autophagy ,apoptosis ,inflammation ,sebastiscus marmoratus ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Hydroxychloroquine (HCQ) is an important public health therapeutic agent widely used in the prevention and treatment of malaria and autoimmune diseases, with some antiviral effects, as well as a common autophagy inhibitor. Its autophagy-inhibiting effect attracts great research interest in mammals but is still little studied in fish. We even have no idea about the effects of HCQ on different tissues of fish and what concentrations should be used for safety studies. This study investigated the effect of different concentration of HCQ treatments on the survival, tissue structure, and expressions of genes related to autophagy, apoptosis, and inflammation in the gill, spleen, testis, and ovary of Sebastiscus marmoratus. The results showed that the higher HCQ concentration (77.40 and 154.80 mg/mL) led to mass mortality within an hour. The half-lethal concentration (LC50, 24 h) of HCQ for S. marmoratus was approximately 48.95 mg/mL. When exposed to 30.96 mg/mL HCQ for 24 hours, autophagy was blocked as revealed by electron microscopy from gill, spleen and testis of fish. The expressions of autophagy-related genes (LC3/Cx43), apoptosis-related genes (Cas3/p53), and inflammation-related genes (TNF-α/IL8) exhibited tissue-specific and dose-dependent responses. The gonads showed preferential expression of all these genes and were found to be sensitive and regular after HCQ treatment. For example, at a concentration of 30.96 mg/mL, the testis demonstrated a regularity that suggests it is an ideal candidate tissue for studying the role of HCQ or autophagy. This study systematically revealed the response of S. marmoratus to different concentrations of HCQ and provided optional assay concentrations for key tissues, serving as an important reference for the future studies on HCQ and autophagy in S. marmoratus. Furthermore, the potential crosstalk between autophagy, apoptosis, and inflammatory pathways initially identified in this study could be helpful for the future research on autophagy regulation in marine fish.
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- 2024
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26. Protect the oceans from Japan's radioisotope dumping
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Chengjun Li, Huan Zhong, Lingyu Meng, Mengjie Wu, Wenjing Ning, Su Shiung Lam, Jun Luo, and Christian Sonne
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Environmental sciences ,GE1-350 ,Environmental technology. Sanitary engineering ,TD1-1066 - Published
- 2024
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27. Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma
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Yu Xiao, Wan Jin, Kaiyu Qian, Lingao Ju, Gang Wang, Kai Wu, Rui Cao, Luyuan Chang, Zilin Xu, Jun Luo, Liuying Shan, Fang Yu, Xintong Chen, Dongmei Liu, Hong Cao, Yejinpeng Wang, Xinyue Cao, Wei Zhou, Diansheng Cui, Ye Tian, Chundong Ji, Yongwen Luo, Xin Hong, Fangjin Chen, Minsheng Peng, Yi Zhang, and Xinghuan Wang
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adaptive immunity ,bladder cancer ,intratumor heterogeneity ,single cell ,TM4SF1‐positive cancer subpopulation ,Science - Abstract
Abstract Intratumor heterogeneity (ITH) of bladder cancer (BLCA) contributes to therapy resistance and immune evasion affecting clinical prognosis. The molecular and cellular mechanisms contributing to BLCA ITH generation remain elusive. It is found that a TM4SF1‐positive cancer subpopulation (TPCS) can generate ITH in BLCA, evidenced by integrative single cell atlas analysis. Extensive profiling of the epigenome and transcriptome of all stages of BLCA revealed their evolutionary trajectories. Distinct ancestor cells gave rise to low‐grade noninvasive and high‐grade invasive BLCA. Epigenome reprograming led to transcriptional heterogeneity in BLCA. During early oncogenesis, epithelial‐to‐mesenchymal transition generated TPCS. TPCS has stem‐cell‐like properties and exhibited transcriptional plasticity, priming the development of transcriptionally heterogeneous descendent cell lineages. Moreover, TPCS prevalence in tumor is associated with advanced stage cancer and poor prognosis. The results of this study suggested that bladder cancer interacts with its environment by acquiring a stem cell‐like epigenomic landscape, which might generate ITH without additional genetic diversification.
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- 2024
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28. Integration fabrication of polyimide composite films for aerospace applications
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Yifan Zhang, Shengqi Dai, Zeyu Yin, Weiqing Yan, Qian Li, Heng Yuan, Xu Zhang, Lin Chen, Jun Luo, Xiao Ouyang, Bin Liao, Wei Hao, and Jia Zhu
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atomic oxygen ,dynamics ,electrostatic discharge ,irradiation ,molecular polyimide ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract Polyimides externally deployed in spacecraft or satellites extensively have various aerospace hazards, including atomic oxygen (AO) erosion, irradiation degradation, and electrostatic charge/discharge (ESC/ESD). To cope with these challenges, we fabricate a ZnO/CuNi‐polyimide composite film with augmented permanence. Using spectroscopy and microscopy techniques, we have shown that the combination of chelation and cross‐linking in the interfacial architecture leads to enhanced interfacial compatibility and mechanical robustness. Besides, due to the positive AO diffusion barrier ability of the wurtzite ZnO, our composite film shows remarkable AO resistance and a very small Ey value of 6.88 × 10−26 cm3/atom, which is merely 2.29% of that of pristine polyimide. Moreover, the well‐defined nanocrystalline state with minimal lattice swelling (0.3%–0.7%) of the Fe+‐irradiated ZnO/CuNi‐polyimide at a damaging dose of 353.4 dpa demonstrates its excellent irradiation resistance. Finally, the ZnO/CuNi‐polyimide also shows sufficient electrostatic dissipation capacity to cope with the ESC/ESD events. Our fabrication approach for composite films based on multi‐technology integration shows potential for aerospace applications and deployment.
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- 2024
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29. XCR1: A promising prognostic marker that pinpoints targeted and immune-based therapy in hepatocellular carcinoma
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Wei Wu, Zhen Bao, Kai Zhu, Danjun Song, Weijian Yang, Jun Luo, Jiaping Zheng, Guoliang Shao, and Junfeng Huang
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XCR1 ,Prognosis ,Hepatocellular carcinoma ,Early-stage ,Sorafenib ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Objectives: The lymphotactin receptor X–C motif chemokine receptor 1 (XCR1) is an essential member of the chemokine receptor family and is related to tumor development and progression. Nevertheless, further investigation is required to explore its expression patterns, prognostic values, and functions related to target or immune therapies in patients with hepatocellular carcinoma (HCC). Materials and methods: The differential expression patterns of XCR1 and its prognostic influences were performed through The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Subsequently, immunohistochemistry (IHC) staining and univariate and multivariate Cox regressions were performed to validate the prognostic values in different subgroups. Furthermore, the potential roles of XCR1 in predicting target and immune therapeutic responses were also investigated. Results: Increased expression level of XCR1 was associated with favorable overall survival (OS) and recurrence-free survival (RFS). Subgroup analysis revealed that a high expression level of XCR1 or positive immune cell proportion score (iCPS) were associated with favorable OS in the HCC patients with favorable tumor characteristics. In addition, the enhanced XCR1 expression was associated with the tumor environment scores, immune cell infiltration levels, and the expression levels of immune checkpoint genes. Further analysis revealed that improved expression of XCR1 was linked to better OS and RFS in HCC patients who received sorafenib. Conclusion: This study identified that XCR1 is a valuable prognostic biomarker in the HCC population, especially in those with favorable tumor characteristics. The combination of iCPS status and BCLC status has a synergistic effect on stratifying patients' OS and RFS. Further analyses showed that XCR1 has the potential ability to predict treatment responses to sorafenib and immune-based therapies.
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- 2024
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30. Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trialResearch in context
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Lina Zheng, Ximing Nie, Mengxing Wang, Xin Liu, Wanying Duan, Zhe Zhang, Jingyi Liu, Yufei Wei, Miao Wen, Zhonghua Yang, Thomas W. Leung, Gaoting Ma, Xiaochuan Huo, Yuesong Pan, Thanh N. Nguyen, Xinyi Leng, Zhongrong Miao, Liping Liu, Yongjun Wang, Yilong Wang, David S. Liebeskind, Zeguang Ren, Vitor Mendes Pereira, Xunming Ji, Qiang Dong, Anding Xu, Xinfeng Liu, Qingwu Yang, Jing Jing (Chair), Yingkui Zhang, Wei Wu, Dapeng Sun, Zhongqi Qi, Shuo Li, Zhenqiang Liu, Zequan Yu, Jingyu Zhang, Fangguang Chen, Kangyue Li, Kai Zhang, Mingkai Hu, Jianmin Liu (Chair), Chen Yao, Kangning Chen, Kun Fang (Chair), Bo Song, Yi Dong, Guangxiong Yuan, Hongxing Han, Wenhuo Chen, Ming Wei, Jiangang Zhang, Zhiming Zhou, Xiaoxi Yao, Guoqing Wang, Weigen Song, Xueli Cai, Guangxian Nan, Di Li, Yizhou Wang, Wentong Ling, Chuwei Cai, Changming Wen, En Wang, Liyong Zhang, Changchun Jiang, Yajie Liu, Geng Liao, Xiaohui Chen, Tianxiao Li, Shudong Liu, Jinglun Li, Yaxuan Sun, Na Xu, Zong’en Gao, Dongsheng Ju, Cunfeng Song, Jinggang Xuan, Feng Zhou, Qing Shi, Jun Luo, Yan Liu, Zaiyu Guo, Tong Li, Hongbo Zheng, Linzhi Dai, Junfeng Zhao, Liqiang Gui, Xiaokun Geng, Yufeng Tang, Congguo Yin, Hua Yang, Ruiyang An, Yuying Sun, Yanan Wu, Chunlai Yu, Shuangcheng Zheng, Aoming Jin, Xianglong Xiang, Hongyi Yan, Yuanling He, Chunyang Li, Weixia Kong, Yuhuan Chen, Chenhao Guo, Fengjie Ji, Pengshan Ji, Lei Liu, Xinghua Lu, Guangkuo Luo, Nanjing Wang, Yu Zhang, Bo Liu, Jian Yang, Jingjing Deng, Juan Wang, Wanru Wang, Hang Yu, Le Cui, Wenwen Liu, Ziyong Wang, Xia Zhao, Zhou Zhou, and Alvin Yi-Chou Wang
- Subjects
Endovascular therapy ,Acute ischaemic stroke ,Large vessel occlusion ,Large infarct core ,Post hoc analysis ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT. Methods: This post-hoc analysis of the ANGEL-ASPECT trial, a randomised controlled trial of 456 adult patients with acute anterior-circulation LVO and large infarction, defined by ASPECTS 3–5 or infarct core volume 70–100 mL, enrolled from 46 centres across China, between October 2, 2020 and May 18, 2022. Patients were randomly assigned (1:1) to receiving EVT and medical management or medical management alone. One patient withdrew consent, 455 patients were included in this post-hoc analysis and categorised into 4 subgroups by lower or higher NIHSS (< or ≥16) and smaller or larger infarct core (< or ≥70 mL). Those with lower NIHSS & smaller core, and higher NIHSS & larger core were considered clinical-radiological matched subgroups; otherwise clinical-radiological mismatched subgroups. Primary outcome was 90-day modified Rankin Scale (mRS). ANGEL-ASPECT is registered with ClinicalTrials.gov, NCT04551664. Findings: Overall, 139 (30.5%) patients had lower NIHSS & smaller core, 106 (23.3%) higher NIHSS & larger core, 130 (28.6%) higher NIHSS & smaller core, and 80 (17.6%) lower NIHSS & larger core. There was significant ordinal shift in the 90-day mRS toward a better outcome with EVT in clinical-radiological matched subgroups: lower NIHSS & smaller core (generalised OR, 1.76; 95% CI, 1.18–2.62; p = 0.01) and higher NIHSS & larger core (1.64; 1.06–2.54; 0.01); but not in the two clinical-radiological mismatched subgroups. Interpretation: Our findings suggested that in patients with anterior-circulation LVO and large infarction, EVT was associated with improved 90-day functional outcomes in those with matched clinical and radiological severities, but not in those with mismatched clinical and radiological severities. Simultaneous consideration of stroke severity and infarct core volume may inform patient selection for EVT. Funding: Unrestricted grants from industry [Covidien Healthcare International Trading (Shanghai), Johnson & Johnson MedTech, Genesis MedTech (Shanghai), and Shanghai HeartCare Medical Technology].
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- 2024
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31. Coloration differences in three Camellia reticulata Lindl. cultivars: ‘Tongzimian’, ‘Shizitou’ and ‘Damanao’
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Yan Qu, Zhi Ou, Qing Qing Yong, Xiang Yao, and Jun Luo
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C. reticulata ‘Damanao’ ,Mixed-color ,CHS ,ANR ,Meristem ,Botany ,QK1-989 - Abstract
Abstract Camellia reticulata Lindl., also known as Yunnan Camellia, is an important ornamental plant in China, especially for its large and stunning flowers. A comprehensive understanding of their coloration mechanisms can aid breeders in developing new cultivars and improving their ornamental value; however, it is still unclear in Yunnan Camellia, especially in mixed-color flowers. In this study, we conducted metabolic and transcriptomic comparison analyses to investigate the coloration differences in three Yunnan Camellia cultivars: C. reticulata ‘Shizitou’ (SZT), C. reticulata ‘Damanao’ (MN), and C. reticulata ‘Tongzimian’ (TZM). Our results revealed that the initial flowering stage may play a critical role in the color change of MN. Metabolome analysis demonstrated that cyanidin was the primary anthocyanin in SZT and MN’s red region, while its content was low in TZM and MN’s white region. According to the transcriptome analysis, the anthocyanins biosynthesis pathway was reconstructed in Yunnan Camellia, and the low expression of CHS was detected in TZM and MN’s white region, while ANR maintained a high expression level, which may lead to the low content of cyanidin in them. Transcription factors MYBs, bHLH, and bZIP may play a key role in regulating anthocyanin-structural genes. The co-expression analysis showed that the meristem tissue may play a crucial role in the formation of the mixed white-red color in MN. Our study enriched the genetic basis of flower coloration differences in Yunnan Camellia which will be a valuable genomic resource to understanding the biology of coloration formation and for breeding the Camellia cultivars.
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- 2024
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32. Timing of general anesthesia for pediatric patients recovering from COVID-19: a prospective cohort study
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Dinghuan Zhao, Wei Liu, Zhao Zhang, Yuting Li, Jun Luo, Weiqiang Zheng, and Ruiqiang Sun
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Child ,COVID-19 ,Anesthesia ,General ,Laryngeal masks ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Objective To explore the timing of general anesthesia for pediatric patients who have recovered from novel coronavirus infection and summarize anesthesia-related complications. Methods We summarized the perioperative management of children under 14 years of age who underwent general anesthesia in our hospital according to national epidemic prevention and control requirements. We compared the incidence of postoperative pulmonary complications within 2 weeks (Group A), 3–4 weeks (Group B), and 5–6 weeks (Group C) after COVID-19 recovery. Results There were differences among the three groups in terms of decreased blood oxygen saturation (
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- 2024
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33. Applications of Deep Learning Models on the Medical Images of Osteonecrosis of the Femoral Head (ONFH): A Comprehensive Review
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Jiao Wang, Yi Zheng, Jun Luo, Timothy Tin-Yan Lee, Pengfei Li, Ying-Qi Zhang, James Chung-Wai Cheung, Duo Wai-Chi Wong, and Ming Ni
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Artificial intelligence ,machine learning ,osteonecrosis ,avascular necrosis ,femoral head collapse hip arthroplasty ,literature review ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Deep learning models have demonstrated promising results in the early and accurate diagnosis of osteonecrosis of the femoral head (ONFH), enabling early detection and informed surgical decision-making. The objective of this review is to summarize the applications of deep learning models on the medical images of ONFH. English papers were searched from CINAHL via EBSCOhost, Embase, IEEE Xplore® Digital Library, PubMed, Scopus, and Web of Science. Sixteen studies (n =16) were eligible for data synthesis. Among these, five studies (n =5) focusing on radiographs, ten studies (n =10) focusing on magnetic resonance imaging, and one study (n =1) focusing on computed tomographic images. The applications of these studies included identifying ONFH from normal or other hip pathologies, classifying severity, segmenting, and detecting femoral head and necrotic regions, predicting signs and symptoms of ONFH, and predicting potential ONFH after fracture fixation. Generally, the models demonstrated good to excellent classification performance and excellent discriminatory power; and generally comparable to that of experienced physicians and superior to that of less experienced physicians. However, the external validity of these studies demonstrated only moderate, as evidenced by the performance on the external testing set and might be attributed to the relatively small data size used during model training. we observed a shift from CNN-based models to U-Net-based models (i.e., with encoder-decoder architecture). In addition to streamlining the segmentation, detection, and classification procedures, future studies will explore multimodal attention, self-supervised learning, explainable models, and data augmentation through generative models.
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- 2024
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34. Dynamic coordination engineering of 2D PhenPtCl2 nanosheets for superior hydrogen evolution
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Gonglei Shao, Changfei Jing, Zhinan Ma, Yuanyuan Li, Weiqi Dang, Dong Guo, Manman Wu, Song Liu, Xu Zhang, Kun He, Yifei Yuan, Jun Luo, Sheng Dai, Jie Xu, and Zhen Zhou
- Subjects
Science - Abstract
Abstract Exploring the dynamic structural evolution of electrocatalysts during reactions represents a fundamental objective in the realm of electrocatalytic mechanism research. In pursuit of this objective, we synthesized PhenPtCl2 nanosheets, revealing a N2-Pt-Cl2 coordination structure through various characterization techniques. Remarkably, the electrocatalytic performance of these PhenPtCl2 nanosheets for hydrogen evolution reaction (HER) surpasses that of the commercial Pt/C catalyst across the entire pH range. Furthermore, our discovery of the dynamic coordination changes occurring in the N2-Pt-Cl2 active sites during the electrocatalytic process, as clarified through in situ Raman and X-ray photoelectron spectroscopy, is particularly noteworthy. These changes transition from Phen-Pt-Cl2 to Phen-Pt-Cl and ultimately to Phen-Pt. The Phen-Pt intermediate plays a pivotal role in the electrocatalytic HER, dynamically coordinating with Cl- ions in the electrolyte. Additionally, the unsaturated, two-coordinated Pt within Phen-Pt provides additional space and electrons to enhance both H+ adsorption and H2 evolution. This research illuminates the intricate dynamic coordination evolution and structural adaptability of PhenPtCl2 nanosheets, firmly establishing them as a promising candidate for efficient and tunable electrocatalysts.
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- 2024
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35. Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity
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Linzi Li, Xueying Lei, Lin Chen, Ya Ma, Jun Luo, Xuebo Liu, Xinglian Xu, Guanghong Zhou, and Xianchao Feng
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Quercetin compounds ,Acrylamide ,Protection mechanism ,Oxidative stress ,Antioxidant activity ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Quercetin compounds have antioxidant, anti-inflammatory and anticancer pharmacological functions. Long-term exposure to acrylamide (AA) can cause liver injury and endanger human health. However, whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear. Here, we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro. In vivo studies found that quercetin-like compounds protect against AA-induced liver injury by reducing oxidative stress levels, activating the Akt/mTOR signaling pathway to attenuate autophagy, and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis. In vitro studies found that quercetin compounds protected HepG2 cells from AA by attenuating the activation of AA-induced autophagy, lowering reactive oxygen species (ROS) levels by exerting antioxidant effects and thus attenuating oxidative stress, increasing mitochondrial membrane potential (MMP), and improving apoptosis-related proteins, thus attenuating AA-induced apoptosis. Furthermore, the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity, with quercetin showing the best protective capacity due to its strongest antioxidant activity. In conclusion, quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress, autophagy and apoptosis, and their protective capacity correlates with antioxidant activity.
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- 2024
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36. Mitochondrial genomes of Bombyliidae (Diptera): Phylogenetic analysis recovers monophyletic Bombyliidae sister to Asilidae
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Gang YAO, Yuxin AN, Jun LUO, Zhen ZHANG, Ding YANG, and Yuyu WANG
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bee flies ,mitochondrial dna ,phylogeny ,asiloidea ,Zoology ,QL1-991 - Abstract
Bombyliidae (bee flies) is a large family in the order Diptera. Their larvae are predators or parasitoids of several insect orders, such as Coleoptera, Lepidoptera, Hymenoptera and Diptera, some species of the genus Systoechus are predators of grasshopper eggs. The adults visit flowers for nectar and mating, which makes them important pollinators. Their classification and systematic position are still strongly debated. There were only two complete mitochondrial (mt) genomes of Bombyliidae. Mt genomes of Villa fasciata, Bombylius candidus, Heteralonia anemosyris, Ligyra guangdongana, Systropus excisus and Exhyalanthrax afer were sequenced in order to determine the diversity of mt genomes in this family. A comparative mt genomic analysis of these newly sequenced species revealed that the sizes of the mt genome ranged from 15,036 bp to 17,992 bp. All tRNAs had cloverleaf secondary structures, but the dihydrouridine (DHU) arm of tRNASer (AGN) is absent. The phylogenetic analyses based on both Bayesian Inference (BI) and Maximum Likelihood (ML) supported Bombyliidae being the sister group of Asilidae. Within Bombyliidae, the analysis recovered subfamilies Toxophorinae, Anthracinae and Bombyliinae, and Anthracinae is the sister group of Bombyliinae.
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- 2023
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37. Effect of intravenous low-dose norepinephrine on blood loss in non-tourniquet total knee arthroplasty under general anesthesia: a randomized, double-blind, controlled, single-center trial
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Shijie Chen, Fenqi Luo, Yuan Lin, Guoyu Yu, Jun Luo, and Jie Xu
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Total knee replacement ,Low-dose epinephrine ,Intravenous pump infusion ,Intraoperative blood loss ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Objective This prospective trial aimed to evaluate the effects of low-dose intravenous norepinephrine (NE) on intraoperative blood loss and bleeding from osteotomy sites during non-tourniquet total knee arthroplasty (TKA) under general anesthesia. Methods A total of 120 patients who underwent TKA between December 2020 and May 2022 were enrolled and randomly assigned to the intravenous low-dose NE Group (NE Group) or the control group (C Group). During surgery, NE Group received 0.05–0.1 μg/(kg min) of NE intravenously to raise and maintain the patient's mean arterial pressure (MAP). C Group received the same dose of saline as placebo. Intraoperative blood loss, bleeding score at osteotomy sites, Δlactate levels (Lac), postoperative complications, and transfusion rate during hospitalization were compared between groups. Results Intraoperative and osteotomy blood loss was significantly lower in the NE Group than in the C Group (P 0.05). There was no significant difference in complications between the groups 3 days after surgery (P > 0.05). In addition, there was no significant difference in blood transfusion rates between the two groups during hospitalization (P > 0.05). Conclusion In non-tourniquet TKA under general anesthesia, low-dose intravenous NE safely and effectively reduced intraoperative blood loss and provided a satisfactory osteotomy site while maintaining a higher MAP.
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- 2023
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38. Closed‐Loop Wearable Device Network of Intrinsically‐Controlled, Bilateral Coordinated Functional Electrical Stimulation for Stroke
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Shuxing Xu, Chengyu Li, Conghui Wei, Xinfang Kang, Sheng Shu, Guanlin Liu, Zijie Xu, Mengdi Han, Jun Luo, and Wei Tang
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closed‐loop network ,functional electrical stimulation ,stroke ,wearable devices ,Science - Abstract
Abstract Innovative functional electrical stimulation has demonstrated effectiveness in enhancing daily walking and rehabilitating stroke patients with foot drop. However, its lack of precision in stimulating timing, individual adaptivity, and bilateral symmetry, resulted in diminished clinical efficacy. Therefore, a closed‐loop wearable device network of intrinsically controlled functional electrical stimulation (CI‐FES) system is proposed, which utilizes the personal surface myoelectricity, derived from the intrinsic neuro signal, as the switch to activate/deactivate the stimulation on the affected side. Simultaneously, it decodes the myoelectricity signal of the patient's healthy side to adjust the stimulation intensity, forming an intrinsically controlled loop with the inertial measurement units. With CI‐FES assistance, patients’ walking ability significantly improved, evidenced by the shift in ankle joint angle mean and variance from 105.53° and 28.84 to 102.81° and 17.71, and the oxyhemoglobin concentration tested by the functional near‐infrared spectroscopy. In long‐term CI‐FES‐assisted clinical testing, the discriminability in machine learning classification between patients and healthy individuals gradually decreased from 100% to 92.5%, suggesting a remarkable recovery tendency, further substantiated by performance on the functional movement scales. The developed CI‐FES system is crucial for contralateral‐hemiplegic stroke recovery, paving the way for future closed‐loop stimulation systems in stroke rehabilitation is anticipated.
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- 2024
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39. Application of a clamshell isothermal nucleic acid amplification analyzer in the detection of lower respiratory tract bacteria
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Guanbin Zhang, Xiaoying Lin, Wenkun Mu, Jun Luo, Yiyuan Xu, Chicheng Song, and Jiang Li
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Isothermal amplification technology ,Point-of-care testing instrument ,Respiratory pathogen detection ,Respiratory tract infection ,Medicine (General) ,R5-920 ,Chemistry ,QD1-999 - Abstract
Objectives: The clamshell isothermal nucleic acid amplification analyzer RTisochip-S, a next-generation instrument featuring improved structural design, enhanced functional integration, reduced cost, and increased portability, was assessed for its suitability in clinical respiratory pathogens detection. Methods: The certificated detection kit for lower respiratory tract bacteria (LRTB-kit) was applied to evaluate the performance of RTisochip-S via sensitivity, specificity, and repeatability analysis. The clinical specimens, including 51 sputum specimens and 10 bronchoalveolar lavage fluid specimens, were simultaneously detected on both RTisochip-S and a certificated reference instrument (RTisochip-A) to assess the consistency. Results: The results indicated that RTisochip-S fulfills the sensitivity, specificity, and repeatability requirements of the LRTB-Kit, and the results of clinical specimens on the two instruments were consistent. Conclusions: RTisochip-S is satisfying the clinical detection of respiratory pathogens while enhancing portability and compactness, making it more well-suited for point-of-care testing (POCT) applications.
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- 2024
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40. Progress in research on the exploration and evaluation of deep geothermal resources in the Fujian-Guangdong-Hainan region, China
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Herong Zheng and Jun Luo
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Deep geothermal resources ,Geology of geothermal energy ,Strategic selection ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
Deep geothermal resources in the Fujian-Guangdong-Hainan region, China, offer significant potential for sustainable energy. The diverse igneous rock formations along the southeast coast present intricate geological challenges that impede exploration and evaluation efforts. In this study, we address critical concerns related to the Fujian-Guangdong-Hainan region's deep geothermal resources, encompassing heat source composition, formation conditions, strategic favorable areas, and exploration directions. Our methods involve the analysis of regional geothermal reservoirs and cap rocks. Major findings include: the primary heat sources in the Fujian-Guangdong-Hainan region consist of the radioactive heat generation from granites in the crust, heat conduction in the mantle, and, in specific areas like Yangjiang and Shantou, melts within the middle and lower crust; the deep, high-temperature geothermal resources in the region predominantly reside in basins' depressed areas. These areas are characterized by the confluence of triple heat sources: heat from the Earth's crust, mantle, and other supplementary sources; our analysis led to the identification of three strategic areas favorable for deep geothermal resources in the Fujian-Guangdong-Hainan region. These are the Beibu Gulf Basin's continental area, the Yuezhong Depression, and the Fuzhou-Zhangzhou area.
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- 2024
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41. Male aggressive behaviors as an indicator in primate tourism management assessment
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Bin Yang, James R. Anderson, Meng-Ya Han, Xin-Yu Meng, Jun Luo, Kang-Sheng Jia, Yong-Feng Chen, Wen-Yong Tian, Bing-Bo Qiao, Chao Zhang, Han-Qing Jing, Pei-Yuan Zhou, and Bao-Guo Li
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Sichuan snub-nosed monkeys ,Ecotourism ,Aggressive behaviors ,Tourism risk assessment ,Ecology ,QH540-549.5 - Abstract
Primate tourism brings many benefits, but also some problems. How to better evaluate primate tourism is of significance for formulating tourism management strategies. In this study, we compared the aggressive behavior of three Sichuan snub-nosed monkey groups that encounter ecotourists and found that male aggressive behavior is a useful indicator for assessing ecotourism of these and, by inference, other groups. In high-risk tourism groups multiple monkeys direct aggression towards tourists, whereas low-risk tourism groups are characterized by low rates of such aggression. We found that tourists touching or attempting to touch the monkeys can trigger aggressive behaviors in all groups, while carrying food and eating have different effects across groups. In well-managed groups, tourist-directed aggressive behaviors are milder than in less well-managed groups. We propose that male monkey aggressive behavior elicited by tourists’ behavior is a useful indicator in assessing primate tourism, and can help guide further improvements in tourism management.
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- 2024
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42. Atomic-level polarization in electric fields of defects for electrocatalysis
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Jie Xu, Xiong-Xiong Xue, Gonglei Shao, Changfei Jing, Sheng Dai, Kun He, Peipei Jia, Shun Wang, Yifei Yuan, Jun Luo, and Jun Lu
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Science - Abstract
Abstract The thriving field of atomic defect engineering towards advanced electrocatalysis relies on the critical role of electric field polarization at the atomic scale. While this is proposed theoretically, the spatial configuration, orientation, and correlation with specific catalytic properties of materials are yet to be understood. Here, by targeting monolayer MoS2 rich in atomic defects, we pioneer the direct visualization of electric field polarization of such atomic defects by combining advanced electron microscopy with differential phase contrast technology. It is revealed that the asymmetric charge distribution caused by the polarization facilitates the adsorption of H*, which originally activates the atomic defect sites for catalytic hydrogen evolution reaction (HER). Then, it has been experimentally proven that atomic-level polarization in electric fields can enhance catalytic HER activity. This work bridges the long-existing gap between the atomic defects and advanced electrocatalysis by directly revealing the angstrom-scale electric field polarization and correlating it with the as-tuned catalytic properties of materials; the methodology proposed here could also inspire future studies focusing on catalytic mechanism understanding and structure-property-performance relationship.
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- 2023
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43. Advances on Axial Coordination Design of Single-Atom Catalysts for Energy Electrocatalysis: A Review
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Linjie Zhang, Na Jin, Yibing Yang, Xiao-Yong Miao, Hua Wang, Jun Luo, and Lili Han
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Single-atom catalyst ,Axial coordination ,Synthetic strategy ,Electrocatalytic application ,Technology - Abstract
Highlights The burgeoning research topic of axially coordinated single-atom catalysts (SACs) is briefly outlined in this review. A comprehensive summary of the recent advances on synthetic strategies and electrocatalytic applications of axially coordinated SACs is provided. The challenges and outlooks for future axially coordinated SACs study have been emphasized.
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- 2023
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44. Outcome and characteristics of nonsecretory multiple myeloma compared with secretory multiple myeloma: a retrospective multicenter study from China
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Hailu Sun, Aijun Liu, Lihong Liu, Wei Wang, Zhen Cai, Hua Yan, Lijuan Chen, Guangxun Gao, Fang Wang, Aijun Liao, Bing Chen, Jia Feng, Juan Li, Dong-Ping Huang, Da Gao, Qi-Ke Zhang, Jun Luo, Rong Fu, Juan Du, and Jin Lu
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Multiple myeloma ,Non secretory ,Clinical feature ,FLC ,Prognosis feature ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Nonsecretory multiple myeloma (NSMM) is a rare type of multiple myeloma (MM). Few studies have described the clinical features and outcomes of NSMM in novel agents. Additionally, the prognostic characteristics have remained controversial in recent years. Purpose To investigate the clinical and prognostic features of NSMM and explore the prognostic value of involved free light chain (FLC) levels in NSMM patients in the Chinese population. Methods We retrospectively enrolled 176 newly diagnosed NSMM cases between January 2005 and December 2021 from 19 clinical centers in China. The control group was selected using a 1:4 propensity score matching technique of newly diagnosed secretory MM, with age, sex and diagnosis time as the matching variables. Results The median age of NSMM patients was 60 years, and 22.6% of patients were classified as ISS stage 3. The ORR of the NSMM patients was 87.4%, and the CR was 65.8%. Compared to the matched secretory MM patients, more NSMM patients achieved CR after first-line treatment (65.8% vs. 36%, p = 0.000). The ORR of first-line treatment was not significantly different between NSMM and secretory MM (89.45% vs. 84.7%, p = 0.196). The first-line PFS was 27.5 m and 23 m (p = 0.063), and the median OS was 81 m and 70 months (p = 0.401). However, for CR-achieved NSMM and CR-not-achieved NSMM patients, the median PFS was 37 m vs. 16 m (p = 0.021), while the median OS showed no difference (107 m vs. 87 m, p = 0.290). In multivariate analysis, the significant factors for PFS were age ≥ 65 and ISS-3. ISS-3 was the only independent prognostic factor of OS. The iFLC ≥ 50 mg/L group had a high ORR of 97.3%, and the median PFS and OS were 48 m and NR, respectively. Compared to the matched secretory MM, the iFLC ≥ 50 mg/L group also showed more CR and longer OS (NR vs. 70 m, p = 0.006) and PFS (48 m vs. 23 m, p = 0.003). Conclusions Our results revealed that Chinese NSMM patients are younger and have a higher CR but not superior survival. The subgroup of NSMM patients with iFLC ≥ 50 mg/L had better outcomes than secretory MM.
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- 2023
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45. Clinical efficacy of ultrasound-guided stellate ganglion block combined with extracorporeal shock wave therapy on limb spasticity in patients with ischemic stroke
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Zhen Yuan, Jun Luo, Qing-feng Cheng, and Qiao Zhang
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Stellate ganglion block (SGB) ,Extracorporeal shock wave therapy (ESWT) ,Myospasm ,Ischemic stroke ,Clinical efficacy ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Introduction To observe the clinical efficacy of ultrasound-guided stellate ganglion block (SGB) + extracorporeal shock wave therapy (ESWT) for limb spasticity in patients with ischemic stroke. Methods A total of 60 patients with post-stroke limb spasticity in our hospital were selected and randomly divided into four groups (n = 15). In the control group, patients received routine rehabilitation training. Based on routine rehabilitation training, SGB group patients underwent ultrasound-guided SGB, ESWT group patients received ESWT, and SGB + ESWT group patients received ultrasound-guided SGB combined with ESWT. The total treatment course was one month. The Modified Barthel Index (MBI) score, Fugl-Meyer Assessment and upper limb rehabilitation training system were applied to evaluate the activities of daily living, upper limb motor function and upper limb performance before and after treatment. Finally, the improvement after treatment was compared among different groups. Results After treatment, compared with the control group, the MBI score and the upper limb score based on Fugl-Meyer Assessment in the SGB, ESWT, and SGB + ESWT groups were significantly increased (P 0.05). In terms of upper limb performance ability, patients in the SGB, ESWT and SGB + ESWT groups had better fitting degree, participation and exertion of exercise than those in the control group, and the SGB + ESWT group patients had the same movement trajectory as robots. Conclusion Ultrasound-guided SGB and ESWT can reduce the muscle tension of patients, alleviate spasticity, promote the motor function of the upper limb, and improve the working performance of patients. However, the effect of SGB combined with ESWT is better.
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- 2023
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46. miR-380-3p promotes β-casein expression by targeting αS1-casein in goat mammary epithelial cells
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Ning Song, Jun Luo, Lian Huang, Xiaoying Chen, Huimin Niu, and Lu Zhu
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α-casein ,goat mammary epithelial cells ,milk allergy ,mir-380-3p ,Zoology ,QL1-991 - Abstract
Objective αS1-Casein is more closely associated with milk allergic reaction than other milk protein components. microRNA (miRNA) is a class of small non-coding RNAs that modulate multiple biological progresses by the target gene. However, the post-transcriptional regulation of αS1-casein expression by miRNA in ruminants remains unclear. This study aims to explore the regulatory roles of miR-380-3p on αS1-casein synthesis in goat mammary epithelial cells (GMEC). Methods αS1-Casein gene and miR-380-3p expression was measured in dairy goat mammary gland by quantitative real-time polymerase chain reaction (qRT-PCR). miR-380-3p overexpression and knockdown were performed by miR-380-3p mimic or inhibitor in GMEC. The effect of miR-380-3p on αS1-casein synthesis was detected by qRT-PCR, western blot, luciferase and chromatin immunoprecipitation assays in GMEC. Results Compared with middle-lactation period, αS1-casein gene expression is increased, while miR-380-3p expression is decreased during peak-lactation of dairy goats. miR-380-3p reduces αS1-casein abundance by targeting the 3′-untranslated region (3′UTR) of αS1-casein mRNA in GMEC. miR-380-3p enhances β-casein expression and signal transducer and activator of transcription 5a (STAT5a) activity. Moreover, miR-380-3p promotes β-casein abundance through target gene αS1-casein, and activates β-casein transcription by enhancing the binding of STAT5 to β-casein gene promoter region. Conclusion miR-380-3p decreases αS1-casein expression and increases β-casein expression by targeting αS1-casein in GMEC, which supplies a novel strategy for reducing milk allergic potential and building up milk quality in ruminants.
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- 2023
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47. Improved clinical outcomes in advanced hepatocellular carcinoma treated with transarterial chemoembolization plus atezolizumab and bevacizumab: a bicentric retrospective study
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Fei Cao, Changsheng Shi, Guofu Zhang, Jun Luo, Jiaping Zheng, and Weiyuan Hao
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Hepatocellular carcinoma ,Atezolizumab ,Bevacizumab ,Overall survival ,Progression-free survival ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose The aim of the present study was to assess the efficacy and safety of transarterial chemoembolization (TACE) combined with atezolizumab and bevacizumab (hereafter, TACE-Atez/Bev) in the treatment of advanced hepatocellular carcinoma (HCC) patients. Materials and methods Clinical information was collected from consecutive patients with advanced HCC who received treatment with TACE-Atez/Bev or Atez/Bev from April 2021 and October 2022. Treatment response, overall survival (OS), and progression-free survival (PFS) were the primary outcomes of this study. Adverse events (AEs) were the secondary outcomes. Propensity score matching (PSM) analysis was applied to reduce bias between two groups. Results This study included 62 patients in the TACE-Atez/Bev group and 77 patients in the Atez/Bev group. The objective response rate (ORR) of the TACE-Atez/Bev group and the Atez/Bev group were 38.7% and 16.9% (P=0.004). However, there was no statistical difference in disease control rate between the two groups (69.4% vs 63.6%, P=0.479). Before PSM, the median OS was 14 months in the TACE-Atez/Bev group and 10 months in the Atez/Bev group (P=0.014). The median PFS in the TACE-Atez/Bev and Atez/Bev groups was 10 months and 6 months, respectively (P=0.001). After PSM, the median OS in the two groups was 14 months and 9 months, respectively (P=0.01). The median PFS was 7 months and 6 months, respectively (P=0.036). Multivariable analysis showed that treatment method was independent prognostic factors affecting OS. Conclusions Compared with Atez/Bev treatment, TACE-Atez/Bev showed better OS, PFS, and ORR for Chinese patients with advanced HCC, with an acceptable safety profile.
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- 2023
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48. Interrupted-Sampling Repeater Jamming Countermeasure Based on Intrapulse Frequency–Coded Joint Frequency Modulation Slope Agile Waveform
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Xiaoge Wang, Binbin Li, Hui Chen, Weijian Liu, Yongzhe Zhu, Jun Luo, and Liuliu Ni
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interrupted-sampling repeater jamming ,frequency modulation slope agility ,frequency-coded ,fractional Fourier transform ,compressed sensing ,electronic counter-countermeasures ,Science - Abstract
Interrupted-sampling repeater jamming (ISRJ) is widely used in the field of electronic countermeasures, and can severely affect radar detection. Therefore, the problem of ISRJ suppression is a compelling task. In this paper, we propose an ISRJ suppression method based on an intrapulse frequency-coded joint frequency modulation (FM) slope agile waveform. The intrapulse frequency-coded joint FM slope agile waveform is first designed. The delay inserted between subpulses makes the waveform easy to implement in engineering, and the ambiguity function diagram of the waveform approximates the ideal thumbtack type. Next, the echo slices are classified in the fractional domain utilizing the discontinuity of ISRJ and the focusing property of fractional Fourier transform for chirp signals. Then, the target and interference in the interfered echo slices are reconstructed by compressed sensing, and a time-domain filter is constructed based on interference-free echo slices. Finally, the echo signal after interference suppression is further filtered in the time domain to degrade range sidelobes. Simulation results show that the proposed method can effectively suppress three typical types of ISRJ. Moreover, the probability of target detection after interference suppression exceeds 90% when the jamming-to-signal ratio equals 50 dB.
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- 2024
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49. Early Crop Identification Study Based on Sentinel-1/2 Images with Feature Optimization Strategy
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Jiansong Luo, Min Xie, Qiang Wu, Jun Luo, Qi Gao, Xuezhi Shao, and Yongping Zhang
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Sentinel-1/2 ,google earth engine ,crop mapping ,Hetao Irrigation District ,random forest model ,model transfer ,Agriculture (General) ,S1-972 - Abstract
The timely and accurate mapping of crop types is crucial for agricultural insurance, futures, and assessments of food security risks. However, crop mapping is currently focused on the post-harvest period, and less attention has been paid to early crop mapping. In this study, the feasibility of using Sentinel-1 (S1) and Sentinel-2 (S2) data for the earliest identifiable time (EIT) for major crops (sunflower, maize, spring wheat, and melon) was explored in the Hetao Irrigation District (HID) of China, based on the Google Earth Engine (GEE) platform. An early crop identification strategy based on the Random Forest (RF) model for HID was proposed, and the performance of the model transfer was evaluated. First, the median synthesis, linear shift interpolation, and the Savitzky–Golay (SG) filter methods were used to reconstruct the time series of S1 and S2. Subsequently, the sensitivity of different input features, time intervals, and data integration to different early crop identifications was evaluated based on the RF model. Finally, the model with optimal parameters was evaluated in terms of its transfer capacity and used for the early mapping of crops in the HID area. The results showed that the features extracted from S2 images synthesized at 10-day intervals performed well in obtaining crop EITs. Sunflower, maize, spring wheat, and melon could be identified 90, 90, 70, and 40 days earlier than the harvest date. The identification accuracy, measured by the F1-score, could reach 0.97, 0.95, 0.98, and 0.90, respectively. The performance of the model transfer is good, with the F1-score decreasing from 0 to 0.04 and no change in EIT for different crops. It was also found that the EIT of crops obtained using S1 data alone was 50–90 days later than that obtained using S2 data alone. Additionally, when S1 and S2 were used jointly, S1 data contributed little to early crop identification. This study highlights the potential of early crop mapping using satellite data, which provides a feasible solution for the early identification of crops in the HID area and valuable information for food security assurance in the region.
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- 2024
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50. Lattice Matching and Microstructure of the Aromatic Amide Fatty Acid Salts Nucleating Agent on the Crystallization Behavior of Recycled Polyethylene Terephthalate
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Tianjiao Zhao, Fuhua Lin, Yapeng Dong, Meizhen Wang, Dingyi Ning, Xinyu Hao, Jialiang Hao, Yanli Zhang, Dan Zhou, Yuying Zhao, Jun Luo, Jingqiong Lu, and Bo Wang
- Subjects
recycled polyethylene terephthalate ,lattice matching ,microstructure ,crystallization behavior ,mechanical properties ,thermal properties ,Organic chemistry ,QD241-441 - Abstract
To solve the decrease in the crystallization, mechanical and thermal properties of recycled polyethylene terephthalate (rPET) during mechanical recycling, the aromatic amide fatty acid salt nucleating agents Na-4-ClBeAmBe, Na-4-ClBeAmGl and Na-4-ClAcAmBe were synthesized and the rPET/nucleating agent blend was prepared by melting blending. The molecular structure, the thermal stability, the microstructure and the crystal structure of the nucleating agent were characterized in detail. The differential scanning calorimetry (DSC) result indicated that the addition of the nucleating agent improved the crystallization temperature and accelerated the crystallization rate of the rPET. The nucleation efficiencies (NE) of the Na-4-ClBeAmBe, Na-4-ClBeAmGl and Na-4-ClAcAmBe were increased by 87.2%, 87.3% and 41.7% compared with rPET which indicated that Na-4-ClBeAmBe and Na-4-ClBeAmGl, with their long-strip microstructures, were more conducive to promoting the nucleation of rPET. The equilibrium melting points (Tm0) of rPET/Na-4-ClBeAmBe, rPET/Na-4-ClBeAmGl and rPET/Na-4-ClAcAmBe were increased by 11.7 °C, 18.6 °C and 1.9 °C compared with rPET, which illustrated that the lower mismatch rate between rPET and Na-4-ClBeAmGl (0.8% in b-axis) caused Na-4-ClBeAmGl to be the most capable in inducing the epitaxial crystallization and orient growth along the b-axis direction of the rPET. The small angle X-ray diffraction (SAXS) result proved this conclusion. Meanwhile, the addition of Na-4-ClBeAmGl caused the clearest increase in the rPET of its flexural strength and heat-distortion temperature (HDT) at 20.4% and 46.7%.
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- 2024
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