109 results on '"Kwang Young Lee"'
Search Results
2. Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning
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A Young Cho, Ju Hwan Oh, Sung Sik Oh, Kwang Young Lee, and In O Sun
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acute kidney injury ,glyphosate ,hypotension ,poisoning ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Background In this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning. Methods This study was performed between 2008 and 2021 and included 184 patients categorized into the AKI (n = 82) and non-AKI (n = 102) groups. The incidence, clinical characteristics, and severity of AKI were compared between the groups based on the Risk of renal dysfunction, Injury to the kidney, Failure or Loss of kidney function, and End-stage kidney disease (RIFLE) classification. Results The incidence of AKI was 44.5%, of which 25.0%, 6.5%, and 13.0% of patients were classified into the Risk, Injury, and Failure categories, respectively. Patients in the AKI group were older (63.3 ± 16.2 years vs. 57.4 ± 17.5 years, p = 0.02) than those in the non-AKI group. The length of hospitalization was longer (10.7 ± 12.1 days vs. 6.5 ± 8.1 days, p = 0.004) and hypotensive episodes occurred more frequently in the AKI group (45.1% vs. 8.8%, p < 0.001). Electrocardiographic (ECG) abnormalities on admission were more frequently observed in the AKI group than in the non-AKI group (80.5% vs. 47.1%, p < 0.001). Patients in the AKI group had poorer renal function (estimated glomerular filtration rate at the time of admission, 62.2 ± 22.9 mL/min/1.73 m2 vs. 88.9 ± 26.1 mL/min/1.73 m2, p < 0.001) on admission. The mortality rate was higher in the AKI group than in the non-AKI group (18.3% vs. 1.0%, p < 0.001). Multiple logistic regression analysis showed that hypotension and ECG abnormalities upon admission were significant predictors of AKI in patients with GSH poisoning. Conclusion The presence of hypotension on admission may be a useful predictor of AKI in patients with GSH intoxication.
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- 2023
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3. The clinical significance of circulating microRNA-21 in patients with IgA nephropathy
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A Young Cho, Ju Hwan Oh, Kwang Young Lee, and In O Sun
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glomerulonephritis ,immunoglobulin a ,micrornas ,Medicine (General) ,R5-920 - Abstract
Background Urinary microRNA-21 (miR-21) has been reported to correlate with the histologic lesions of IgA nephropathy (IgAN). We investigated whether urinary or circulating miR-21 could serve as a biomarker for detecting the renal progression of IgAN. Methods Forty patients with biopsy-proven IgAN were enrolled in this study. Serum and urinary sediment miRs were extracted, and the expression of miR-21 was quantified by real-time quantitative polymerase chain reaction. Renal progression was defined as end-stage renal disease, a sustained doubling of serum creatinine, or a 50% decrease in estimated glomerular filtration rate (eGFR) from baseline. Results Six patients experienced renal progression during the follow-up period. The baseline eGFR was lower in the progression group (49±11 mL/min/1.73 m2 vs. 90±23 mL/min/1.73 m2, p
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- 2022
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4. Vesicoureteral reflux-associated hydronephrosis in a dialysis patient treated with percutaneous nephrostomy
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Ju Hwan Oh, Min Woo Kim, Jung Hwa Kim, A Young Cho, In O Sun, and Kwang Young Lee
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dialysis ,percutaneous nephrostomy ,vesico-ureteral reflux ,Medicine - Abstract
Patients with vesicoureteral reflux (VUR), the retrograde flow of urine from the bladder to the kidney, are known to experience renal scarring; this results in the worsening of renal function. Reflux nephropathy is a cause of chronic kidney disease, and VUR has also been observed in dialysis patients. VUR is a major underlying precursor condition of urinary tract infection (UTI) and is sometimes accompanied by hydronephrosis. However, there are no guidelines for the management of UTI due to VUR-associated hydronephrosis in patients with end-stage kidney disease. Herein, we report a case of UTI caused by VUR-associated hydronephrosis in a dialysis patient treated with percutaneous nephrostomy.
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- 2022
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5. Clinical Usefulness of Contrast-Enhanced Computed Tomography in Patients with Non-Obstructive Acute Pyleonephritis
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In O Sun, Ji Hye Lim, Ju Hwan Oh, A Young Cho, Beum Jin Kim, Kwang Young Lee, and Mi Sook Lee
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acute kidney injury ,computed tomography ,pyelonephritis ,Medicine (General) ,R5-920 - Abstract
Objectives The aim of this study is to investigate the clinical utility of contrast-enhanced computed tomography (CE-CT) in patient with non-obstrcutive acute pyelonephritis (APN). Methods From 2007 to 2013, 537 APN patients who underwent a CE-CT scan within 24 hours after hospital admission were enrolled. We divided these patients into greater (50% or greater involvment, n = 143) and lesser (less than 50% involvement, n = 394) groups based on renal parenchymal involvement in CE-CT examination. We compared clinical characteristics between two groups and analyzed the clinical value of CE-CT scan as a reliable marker for predicting clinical severity and disease course in patient with non-obstructive APN. Results The mean estimated glomerular filtration rate was 70.6 ± 25.5 mL/min/1.73m2. Compared with patients in lesser group, the patients in greater group had lower serum albumin levels (3.5 ± 0.5 vs 3.8 ± 0.6, P < 0.01) and longer hosptal stay (10.1 ± 4.7 vs 8.8 ± 4.5, P < 0.05). In addition, acute kidney injury (AKI) (23.1% vs 11.4%, P < 0.005) and bacteremia (36.4% vs 26.8%, P = 0.02) were frequently developed in greater group, respectively. The overall incidence of AKI was 14.8% based on RIFLE criteria. In a multivariate logistic regression analysis for predciting AKI, age, presence of diabetes mellitus and the presence of renal parenchymal involvement of greater than 50% in CE-CT were significant predictors of AKI. Conclusions The CE-CT scan could be useful to predict the clinical severity and course in non-obstructive APN patients with preserved renal function.
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- 2020
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6. Clinical significance of abnormal chest radiographic findings for acute kidney injury in patients with scrub typhus
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Hyun Ju Yang, Sung-Min Kim, Jin Sol Choi, Ju Hwan Oh, A Young Cho, Mi Sook Lee, Kwang Young Lee, and In O Sun
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acute kidney injury ,chronic kidney disease ,radiography ,scrub typhus ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Background : : Abnormal chest radiographs are frequently encountered in patients with scrub typhus. This study aimed to investigate whether chest radiography on admission is significant as a predictive factor for acute kidney injury (AKI) in patients with scrub typhus. Methods : : From 2010 to 2016, 467 patients were diagnosed with scrub typhus in our hospital. We divided the patients into two groups: normal chest radiograph (NCR) and abnormal chest radiograph (AbNCR), based on chest radiography findings. The incidence, clinical characteristics, and severity of AKI were compared between AKI and non-AKI groups according to the RIFLE classification. Results : : Of the 467 patients, 96 (20.6%) constituted the AbNCR group. Compared with NCR patients, AbNCR patients were older (71 ± 11 vs. 62 ± 13 years, P < 0.001) and had higher total leukocyte counts (9.43 × 103/mL vs. 6.98 × 103/mL, P < 0.001). The AbNCR group had significantly longer duration of hospital stay (8.9 ± 5.5 vs. 6.3 ± 2.8 days, P < 0.001) and higher incidence of AKI (46.9% vs. 15.1%, P < 0.001). The common abnormal chest radiographic findings were pulmonary abnormalities, such as pulmonary congestion and pleural effusion. The overall AKI incidence was 21.6%, of which 12.4%, 7.9%, and 1.3% cases were classified as risk, injury, and failure, respectively. In a multivariable logistic regression analysis for association with AKI, old age, presence of chronic kidney disease or hypertension, leukocytosis, hypoalbuminemia, and chest radiographic abnormalities on admission were significant predictors of AKI. Conclusion : : Chest radiographic abnormalities on admission were independently associated with AKI in patients with scrub typhus.
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- 2020
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7. A severe case of tenofovir-associated acute kidney injury requiring hemodialysis in a patient with chronic hepatitis B
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A Young Cho, Ju Hwan Oh, Hee-Chan Moon, Gum Mo Jung, Young Suk Lee, Yeong Jin Choi, In O Sun, and Kwang Young Lee
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Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Published
- 2020
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8. Transplantation of a kidney from a donor with vancomycin-resistant Enterococci
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Ji Hye Lim, Chan Jung Kim, Ju Hwan Oh, A Young Cho, Mi Ok Chang, Young Suk Kim, Kwang Young Lee, and In O Sun
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kidney transplantation ,vancomycin ,enterococcus ,Medical technology ,R855-855.5 - Abstract
The colonization of vancomycin-resistant Enterococci before and after solid organ transplantation is associated with an increased risk of its infection. The prevalence of these bacterial colonies in renal transplant recipients are as high as that in intensive care unit patients. However, it is unclear whether donors with vancomycin-resistant Enterococci colonization can be considered in renal transplantation. Herein, we report a case wherein a kidney was transplanted from a deceased donor with vancomycin-resistant Enterococci colonies in urine and rectal swab. After transplant, the recipient had no vancomycin-resistant Enterococci infection and maintained relatively good renal function.
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- 2020
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9. Clinical significance of hypoalbuminemia in patients with scrub typhus complicated by acute kidney injury.
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Ju Hwan Oh, Ji Hye Lim, A Young Cho, Kwang Young Lee, and In O Sun
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Medicine ,Science - Abstract
BackgroundThis study aimed to investigate the clinical significance of hypoalbuminemia (HA) in patients with scrub typhus complicated by acute kidney injury (AKI).MethodsFrom 2009 to 2018, 611 patients were diagnosed with scrub typhus. We divided the patients into two groups [normoalbuminemia (NA) vs. HA] based on the serum albumin level of 3.0 g/dL and compared the incidence, clinical characteristics, and severity of AKI based on the RIFLE classification between the two groups.ResultsOf the total 611 patients, 78 (12.8%) were categorized into the HA group. Compared to patients in the NA group, patients in the HA group were older (73 ± 9 vs. 62 ± 14 years, PConclusionSerum albumin level is helpful to predict the development and severity of scrub typhus-associated AKI.
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- 2021
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10. Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy
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A. Young Cho, Hyun Ju Yoon, Kwang Young Lee, and In O. Sun
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Acute kidney injury ,continuous renal replacement therapy ,sepsis ,platelet ,urine output ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective: The aim of this study was to investigate the clinical characteristics of sepsis-induced acute kidney injury (AKI) in patients undergoing continuous renal replacement therapy (CRRT). Methods: From 2011 to 2015, we enrolled 340 patients who were treated with CRRT for sepsis at the Presbyterian Medical Center. In all patients, CRRT was performed using the PRISMA platform. We divided these patients into two groups (survivors and non-survivors) according to the 28-day all-cause mortality. We compared clinical characteristics and analyzed the predictors of mortality. Results: The 28-day all-cause mortality was 62%. Survivors were younger than non-survivors and had higher platelet counts (178 ± 101 × 103/mL vs. 134 ± 84 × 103/mL, p 0.05 mL/kg/h (66% vs. 86%, p = .001) in the first day. In a multivariate logistic regression analysis, age, platelet count, RDW score, APACHE II score, serum creatinine level, and a urine output of
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- 2018
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11. Comparison of clinical characteristics of patients with acute kidney injury after intravenous versus inhaled colistin therapy
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A Young Cho, Hyun Ju Yoon, Jung Cheol Lee, Jin Young Kwak, Kwang Young Lee, and In O Sun
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Acute kidney injury ,Colistin ,Inhaler ,Intravenous ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Background: The aim of this study was to investigate the incidence and clinical characteristics of intravenous (IV) or inhaled (IH) colistin-associated acute kidney injury (AKI) using the Risk, Injury, Failure, Loss, End-stage Renal Disease criteria. Methods: From 2010 to 2014, 160 patients were treated with IV or IH colistin. Of these, we included 126 patients who received colistin for > 72 hours for the treatment of pneumonia and compared the incidence and clinical characteristics of patients in the IV (n = 107) and IH (n = 19) groups. Results: The patients included 104 men and 22 women, with a mean age of 69 years (range, 24–91 years). The mortality rate was 45%, and AKI occurred in 75 (60%) patients. At the end of therapy, the bacteriologic cure rate was 66%. There were no differences in the clinical characteristics between the IV and IH groups except for age. In comparison with patients in the IV group, the patients in the IH group were older (74 ± 8 vs. 68 ± 12 years, P = 0.026). The incidence of AKI was not different between the 2 groups (62 vs. 47%, P = not significant), and there was no difference in the severity of AKI according to the Risk, Injury, Failure, Loss, End-stage Renal Disease criteria. Of the 83 patients with AKI, 6 and 1 patients underwent renal replacement therapy, respectively. Conclusion: The incidence of AKI in patients with colistin therapy is 60% in our center. It seems that IH colistin therapy could not be better in safety than IV colistin therapy.
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- 2016
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12. Predicting the probability of survival in acute paraquat poisoning
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In O Sun, Sung Hye Shin, Hyun Ju Yoon, and Kwang Young Lee
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Creatinine ,Logistic models ,Paraquat ,Prognosis ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Background: Paraquat (PQ) concentration–time data have been used to predict prognosis for 3 decades. The aim of this study was to find a more accurate method to predict the probability of survival. Methods: This study included 788 patients with PQ poisoning who were diagnosed using plasma PQ concentration between January 2005 and August 2012. We divided these patients into 2 groups (survivors vs. nonsurvivors), compared their clinical characteristics, and analyzed the predictors of survival. Results: The mean age of the included patients was 57 years (range, 14–95 years). When we compared clinical characteristics between survivors (n = 149, 19%) and nonsurvivors (n = 639, 81%), survivors were younger (47 ± 14 years vs. 59 ± 16 years) and had lower plasma PQ concentrations (1.44 ± 8.77 μg/mL vs. 80.33 ± 123.15 μg/mL) than nonsurvivors. On admission, serum creatinine was lower in survivors than in nonsurvivors (0.95 ± 0.91 mg/dL vs. 1.88 ± 1.27 mg/dL). In multivariate logistic regression analysis, age and logarithmically converted serum creatinine [ln(Cr)], [ln(time)], and [ln(PQ)] were assessed as prognostic factors to predict survival in PQ poisoning. The predicted probability of survival using significant prognostic factors was exp (logit)/[1 + exp(logit)], where logit = –1.347 + [0.212 × sex (male = 1, female = 0)] + (0.032 × age) + [1.551 × ln(Cr)] + [0.391 × ln(hours since ingestion)] + [1.076 × ln(plasma PQ μg/mL)]. With this equation, the sensitivity and specificity were 86.5% and 98.7%, respectively. Conclusion: Age, ln(Cr), ln(time), and ln(PQ) were important prognostic factors in PQ poisoning, and our equation can be helpful to predict the survival in acute PQ poisoning patients.
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- 2016
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13. Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis
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In O. Sun, Byung Ha Chung, Hyun Ju Yoon, Jeong Ho Kim, Bum Soon Choi, Cheol Whee Park, Yong Soo Kim, Chul Woo Yang, and Kwang Young Lee
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Erythrocyte indices ,Peritoneal dialysis ,Red blood cell distribution width ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Background: In this study, we assessed whether red blood cell distribution width (RDW) was associated with all-cause mortality in patients on peritoneal dialysis (PD) and evaluated its prognostic value. Methods: This study included 136 patients who had RDW levels at PD initiation from January 2007 to January 2014 at the Presbyterian Medical Center and Seoul St. Mary's Hospital. We divided these patients into 2 groups (survivors vs. nonsurvivors), compared their clinical characteristics, and analyzed the predictors of survival. Results: The study included 79 men and 57 women, with a mean age of 54 years (range, 15–85 years). The mean follow-up duration was 32 months (range, 1–80 months). Of 136 patients, 14 died during the follow-up period. When clinical characteristics of survivors (n = 122) and nonsurvivors (n = 14) were compared, no differences were identified, with the exception of serum albumin, total iron-binding capacity (TIBC), left ventricular ejection fraction, total leukocyte count, and RDW value. Survivors had higher serum albumin (3.4 ± 0.5 vs. 3.0 ± 0.5 g/dL, P
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- 2016
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14. Acute interstitial nephritis induced by Solanum nigrum
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Sung Sik Oh, Myung Woo Choi, Mi Rim Choi, Jong Hwa Lee, Hyun Ju Yang, Yeong Jin Choi, A Young Cho, Kwang Young Lee, and In O Sun
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Acute interstitial nephritis ,Corticosteroid ,Solanum ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury and pathologically characterized by inflammatory infiltrate in the renal interstitium. Solanum nigrum (S. nigrum) is a medicinal plant member of the Solanaceae family. Although S. nigrum has been traditionally used to treat various ailments such as pain, inflammation, and fever, it has also been reported to have a toxic effect, resulting in anticholinergic symptoms. However, there have been no reports of AIN caused by S. nigrum. Here, we report the first case of biopsy-confirmed AIN after ingestion of S. nigrum. The patient was successfully treated using corticosteroid therapy.
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- 2016
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15. Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.
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In O Sun, Sung Hye Shin, A Young Cho, Hyun Ju Yoon, Mi Yok Chang, and Kwang Young Lee
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Medicine ,Science - Abstract
The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus.From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI.Of the 138 patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure, respectively, according to RIFLE criteria. Compared with patients in the non-AKI group, patients in the AKI group were older and showed higher total leukocyte counts and hypoalbuminemia or one or more comorbidities such as hypertension (72% vs 33%, p
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- 2017
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16. A case of peritoneal dialysis-associated peritonitis by Rothia mucilaginosa
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Byeong Gwan Kim, A Young Cho, Sang Sun Kim, Seong Hee Lee, Hong Shik Shin, Hyun Ju Yoon, Jeong Gwan Kim, In O Sun, and Kwang Young Lee
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Continuous ambulatory peritoneal dialysis ,Peritonitis ,Rothia mucilaginosa ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Rothia muciliaginosa (R. mucilaginosa) is a facultative, Gram-positive coccus that is considered to be part of the normal flora of the mouth and respiratory tract. There are sporadic reports of the organism causing endocarditis in patients with heart valve abnormalities, as well as meningitis, septicemia, and pneumonia associated with intravenous drug abuse. However, it is an unusual pathogen in cases of peritoneal dialysis (PD)-associated peritonitis. Although R. mucilaginosa is generally susceptible to penicillin, ampicillin, cefotaxime, imipenem, rifampicin, and glycopeptides, there are no guidelines for the treatment of PD-associated peritonitis. Herein, we report a case of PD-associated peritonitis due to R. mucilaginosa that was resolved with intraperitoneal antibiotic treatment.
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- 2015
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17. Idiopathic retroperitoneal fibrosis associated with Hashimoto's thyroiditis in a patient with a single functioning kidney
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Byung Sun Kim, Woong Ki Lee, Hye Mi Choi, Choong Sil Seong, Hyeuk Soo Lee, Jeong Gwan Kim, Min Woo Kim, Kwang Young Lee, and In O Sun
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Corticosteroid ,Hashimoto's thyroiditis ,Intraureteral stent ,Retroperitoneal fibrosis ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Retroperitoneal fibrosis (RPF) is a rare disease characterized by the presence of fibroinflammatory tissue around the abdominal aorta and ureteral entrapment in most cases. Idiopathic RPF is frequently reported in association with autoimmune diseases; however, there have been few reports of idiopathic RPF associated with Hashimoto's thyroiditis. Here, we report a case of idiopathic RPF with Hashimoto's thyroiditis in a patient with a single functioning kidney, which was successfully treated by corticosteroid therapy and transient intraureteral stent insertion with a double-J catheter.
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- 2013
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18. A case of peritoneal dialysis-associated peritonitis caused by Sphingomonas paucimobilis
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Jae Un Lee, Joong Keun Kim, So Hee Yun, Moon Sik Park, Na Eun Lee, In O Sun, and Kwang Young Lee
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Peritoneal dialysis ,Peritonitis ,Sphingomonas paucimobilis ,Internal medicine ,RC31-1245 ,Specialties of internal medicine ,RC581-951 - Abstract
Sphingomonas paucimobilis is an aerobic Gram-negative bacillus found in soil and water. Knowledge regarding the role of this infectious agent is limited because it is rarely isolated from human material. Furthermore, it is an unusual pathogen in cases of peritoneal dialysis (PD)-associated peritonitis. The clinical courses and outcomes of peritonitis caused by S. paucimobilis are variable. Whereas some patients were cured with appropriate antibiotic therapy, others required catheter removal. Cases of PD-associated peritonitis caused by S. paucimobilis have been reported worldwide, and there was a case report of coinfection with S. paucimobilis and Chryseobacterium indologenes in Korea. However, there has been no case caused by S. paucimobilis as a single pathogen. We report a case of PD-associated peritonitis due to S. paucimobilis in which the patient recovered after catheter removal.
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- 2013
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19. Interactivity attributes: a new way of thinking and describing interactivity.
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Youn-Kyung Lim, Sang-Su Lee, and Kwang-young Lee
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- 2009
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20. A Rare Case of Spinal Epidural Abscess Following Urinary Tract Infection Caused by Escherichia coli in a Patient with Pre-existing Stress Fractures of the Lumbar Spine
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Wooram Shin, Ju Hwan Oh, A Young Cho, In Sup Song, Young Suk Kim, Kwang Young Lee, and In O Sun
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Family Practice - Abstract
Spinal epidural abscess (SEA) caused by Escherichia coli is an uncommon condition. It usually occurs secondary to urinary tract infection (UTI), following hematogenous propagation. Disruption of spinal anatomic barriers increases susceptibility to SEA. Although rarely, such disruption can take the form of lumbar spine stress fractures, which can result from even innocuous activity. Here, we describe a case of SEA secondary to UTI in a patient with pre-existing stress fractures of the lumbar spine, following use of an automated massage chair. Successful treatment of SEA consisted of surgical debridement and a six-month course of antibiotic therapy.
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- 2022
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21. Urinary Exosomal microRNA-21 as a Marker for Scrub Typhus-Associated Acute Kidney Injury
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Ji Hye Lim, In O Sun, Chi Young Yun, A Young Cho, Ju Hwan Oh, and Kwang Young Lee
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Male ,China ,Pathology ,medicine.medical_specialty ,Urinary system ,Urine ,Scrub typhus ,Exosomes ,Exosome ,microRNA ,medicine ,Humans ,Genetics (clinical) ,Aged ,Aged, 80 and over ,urogenital system ,business.industry ,Acute kidney injury ,General Medicine ,Acute Kidney Injury ,Middle Aged ,medicine.disease ,MicroRNAs ,Scrub Typhus ,Biomarker (medicine) ,Female ,business ,Biomarkers - Abstract
Background: Urinary microRNA (miRNA)-21 is a biomarker for acute kidney injury (AKI). We conducted this study to determine if a urinary exosomal analysis for this biomarker could serve as a novel d...
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- 2021
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22. Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits Potent In Vitro and In Vivo Anti-Inflammatory Effects Through NF-κB, AP-1, and JAK/STAT Inactivation
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Seo-Yeon Kim, Ahmed H.E. Hassan, Kyung-Sook Chung, Su-Yeon Kim, Hee-Soo Han, Hwi-Ho Lee, Seang-Hwan Jung, Kwang-Young Lee, Ji-Sun Shin, Eungyeong Jang, Seolmin Yoon, Yong Sup Lee, and Kyung-Tae Lee
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Pharmacology ,Pharmacology (medical) - Abstract
TMS-HDMF-5z is a hybrid of the natural products mosloflavone and resveratrol. It was discovered to show potent inhibitory effects against lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophages. However, its mechanism of action is unknown. Hence this study aimed to demonstrate and explore in vitro and in vivo anti-inflammatory effects of TMS-HDMF-5z and its mechanism of action employing RAW 264.7 macrophages and carrageenan-induced hind paw edema. This work revealed that TMS-HDMF-5z suppressed the LPS-induced inducible nitric-oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein, mRNA, and promoter binding levels and tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6, and interferon-β (IFN-β) at the mRNA expression in RAW 264.7 macrophages. The results showed that TMS-HDMF-5z reduced the transcription and DNA binding activities of nuclear factor-κB (NF-κB) through inhibiting nuclear translocation of p65 and phosphorylation of κB inhibitor α (IκBα), IκB kinase (IKK), and TGF-β activated kinase 1 (TAK1). Additionally, TMS-HDMF-5z attenuated the LPS-induced transcriptional and DNA binding activities of activator protein-1 (AP-1) by suppressing nuclear translocation of phosphorylated c-Fos, c-Jun, and activating transcription factor 2 (ATF2). TMS-HDMF-5z also reduced the LPS-induced phosphorylation of Janus kinase 1/2 (JAK1/2), signal transducers and activators of transcription 1/3 (STAT1/3), p38 mitogen-activated protein kinase (MAPK), and MAPK-activated protein kinase 2 (MK2). In rats, TMS-HDMF-5z alleviated carrageenan-induced hind paw edema through the suppressing iNOS and COX-2 via NF-κB, AP-1, and STAT1/3 inactivation. Collectively, the TMS-HDMF-5z-mediated inhibition of NF-κB, AP-1, and STAT1/3 offer an opportunity for the development of a potential treatment for inflammatory diseases.
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- 2022
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23. Clinical significance of abnormal chest radiographic findings for acute kidney injury in patients with scrub typhus
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Kwang Young Lee, A Young Cho, Jin Sol Choi, Sung Min Kim, Ju Hwan Oh, In O Sun, Mi Sook Lee, and Hyun Ju Yang
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lcsh:Internal medicine ,medicine.medical_specialty ,lcsh:Specialties of internal medicine ,Pleural effusion ,030232 urology & nephrology ,Scrub typhus ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,lcsh:RC581-951 ,Chronic kidney disease ,Internal medicine ,medicine ,Hypoalbuminemia ,Leukocytosis ,lcsh:RC31-1245 ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Acute kidney injury ,General Medicine ,medicine.disease ,Radiography ,Original Article ,medicine.symptom ,Chest radiograph ,business ,Kidney disease - Abstract
Background : : Abnormal chest radiographs are frequently encountered in patients with scrub typhus. This study aimed to investigate whether chest radiography on admission is significant as a predictive factor for acute kidney injury (AKI) in patients with scrub typhus. Methods : : From 2010 to 2016, 467 patients were diagnosed with scrub typhus in our hospital. We divided the patients into two groups: normal chest radiograph (NCR) and abnormal chest radiograph (AbNCR), based on chest radiography findings. The incidence, clinical characteristics, and severity of AKI were compared between AKI and non-AKI groups according to the RIFLE classification. Results : : Of the 467 patients, 96 (20.6%) constituted the AbNCR group. Compared with NCR patients, AbNCR patients were older (71 ± 11 vs. 62 ± 13 years, P < 0.001) and had higher total leukocyte counts (9.43 × 103/mL vs. 6.98 × 103/mL, P < 0.001). The AbNCR group had significantly longer duration of hospital stay (8.9 ± 5.5 vs. 6.3 ± 2.8 days, P < 0.001) and higher incidence of AKI (46.9% vs. 15.1%, P < 0.001). The common abnormal chest radiographic findings were pulmonary abnormalities, such as pulmonary congestion and pleural effusion. The overall AKI incidence was 21.6%, of which 12.4%, 7.9%, and 1.3% cases were classified as risk, injury, and failure, respectively. In a multivariable logistic regression analysis for association with AKI, old age, presence of chronic kidney disease or hypertension, leukocytosis, hypoalbuminemia, and chest radiographic abnormalities on admission were significant predictors of AKI. Conclusion : : Chest radiographic abnormalities on admission were independently associated with AKI in patients with scrub typhus.
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- 2020
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24. Strain-Specific Identification and In Vivo Immunomodulatory Activity of Heat-Killed Latilactobacillus sakei K040706
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Kyung-Sook Chung, Jae Woong Choi, Ji-Sun Shin, Seo-Yeon Kim, Hee-Soo Han, Su-Yeon Kim, Kwang-Young Lee, Joo-Yeon Kang, Chang-Won Cho, Hee-Do Hong, Young Kyoung Rhee, and Kyung-Tae Lee
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heat-killed Latilactobacillus sakei ,immune improvement ,cyclophosphamide ,microbiota ,splenocyte ,Health (social science) ,Chemical technology ,TP1-1185 ,Plant Science ,Health Professions (miscellaneous) ,Microbiology ,Food Science - Abstract
We previously reported that the immunostimulatory activity of heat-killed Latilactobacillus sakei K040706 in macrophages and cyclophosphamide (CTX)-treated mice. However, identification of heat-killed L. sakei K040706 (heat-killed LS06) using a validated method is not yet reported. Further, the underlying molecular mechanisms for its immunostimulatory effects in CTX-induced immunosuppressed mice remain unknown. In this study, we developed strain-specific genetic markers to detect heat-killed L. sakei LS06. The lower detection limit of the validated primer set was 2.1 × 105 colony forming units (CFU)/mL for the heat-killed LS06 assay. Moreover, oral administration of heat-killed LS06 (108 or 109 CFU/day, p.o.) effectively improved the body loss, thymus index, natural killer cell activity, granzyme B production, and T and B cell proliferation in CTX-treated mice. In addition, heat-killed LS06 enhanced CTX-reduced immune-related cytokine (interferon-γ, interleukin (IL)-2, and IL-12) production and mRNA expression. Heat-killed LS06 also recovered CTX-altered microbiota composition, including the phylum levels of Bacteroidetes, Firmicutes, and Proteobacteria and the family levels of Muribaculaceae, Prevotellaceae, Tannerellaceae, Christensenellaceae, Gracilibacteraceae, and Hungateiclostridiaceae. In conclusion, since heat-killed L. sakei K040706 ameliorated CTX-induced immunosuppression and modulated gut microbiota composition, they have the potential to be used in functional foods for immune regulation.
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- 2021
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25. A severe case of tenofovir-associated acute kidney injury requiring hemodialysis in a patient with chronic hepatitis B
- Author
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Ju Hwan Oh, Yeong Jin Choi, Kwang Young Lee, Gum Mo Jung, Hee-Chan Moon, A Young Cho, Young Suk Lee, and In O Sun
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medicine.medical_specialty ,lcsh:Internal medicine ,Tenofovir ,lcsh:Specialties of internal medicine ,business.industry ,medicine.medical_treatment ,MEDLINE ,Acute kidney injury ,General Medicine ,medicine.disease ,Chronic hepatitis ,lcsh:RC581-951 ,Internal medicine ,Correspondence ,medicine ,Hemodialysis ,business ,lcsh:RC31-1245 ,medicine.drug - Published
- 2020
26. Transplantation of a kidney from a donor with vancomycin-resistantEnterococci
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Kwang Young Lee, Young Suk Kim, Mi Ok Chang, Chan Jung Kim, In O Sun, Ju Hwan Oh, Ji Hye Lim, and A Young Cho
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Kidney ,medicine.medical_specialty ,biology ,business.industry ,Renal function ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,biology.organism_classification ,Intensive care unit ,Gastroenterology ,law.invention ,Transplantation ,surgical procedures, operative ,medicine.anatomical_structure ,Enterococcus ,law ,Internal medicine ,medicine ,Vancomycin ,Colonization ,business ,Kidney transplantation ,medicine.drug - Abstract
The colonization of vancomycin-resistant Enterococci before and after solid organ trans plantation is associated with an increased risk of its infection. The prevalence of these bacterial colonies in renal transplant recipients are as high as that in intensive care unit patients. However, it is unclear whether donors with vancomycin-resistant Enterococci colonization can be considered in renal transplantation. Herein, we report a case wherein a kidney was transplanted from a deceased donor with vancomycin-resistant Entero cocci colonies in urine and rectal swab. After transplant, the recipient had no vancomy cin-resistant Enterococci infection and maintained relatively good renal function.
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- 2020
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27. Effect of a protected blend of organic acids and medium-chain fatty acids on growth performance, nutrient digestibility, blood profiles, meat quality, faecal microflora, and faecal gas emission in finishing pigs
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H. N. Tran, I. H. Kim, Kwang Young Lee, and Dinh Hai Nguyen
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0301 basic medicine ,03 medical and health sciences ,Nutrient digestibility ,030109 nutrition & dietetics ,Food Animals ,Chemistry ,0402 animal and dairy science ,Animal Science and Zoology ,04 agricultural and veterinary sciences ,Food science ,Body weight ,040201 dairy & animal science ,Finishing pig - Abstract
A total of 105 finishing pigs [(Yorkshire × Landrace) × Duroc] with an initial body weight of 51.0 ± 3.33 kg were used in a 10 wk trial to evaluate the effect of a protected blend of organic acids ...
- Published
- 2019
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28. Metallic contact induced van der Waals gap in a MoS2 FET
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Kwang Young Lee, Won Jong Yoo, Chang Sik Kim, Sudarat Issarapanacheewin, and Inyong Moon
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Materials science ,Analytical chemistry ,02 engineering and technology ,Substrate (electronics) ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Metal ,symbols.namesake ,visual_art ,Electrode ,Scanning transmission electron microscopy ,visual_art.visual_art_medium ,symbols ,Electrical performance ,General Materials Science ,van der Waals force ,0210 nano-technology ,Spectroscopy - Abstract
Electrical metal contacts formed with 2D materials strongly affect device performance. Here, we used scanning transmission electron microscopy (STEM) and energy-dispersive spectroscopy (EDS) to characterize the interfacial structure formed and physical damage induced between MoS2 and the most commonly used metals, Ti, Cr, Au, and Pd. We further correlated the electrical performance with physical defects observed at the 2D interfacial structure. The contact resistances were higher in the order of Ti, Au, Pd, and Cr contacts, but all 4-point probe mobilities measured with metals in contact with identical quadrilayer MoS2 were ∼65 cm2 V−1 s−1, confirming the reliability of the devices. According to the STEM and EDS analyses, the Ti contact gave rise to a van der Waals gap between the clean quadrilayer MoS2 and the Ti contact. By contrast, Cr migrated into MoS2 while Mo and S counter-migrated into the SiO2 substrate. Au and Pd formed glassy layers that resulted in the migration of Mo and S into the Au and Pd electrodes. These interfacial structures between MoS2 and contact metals strongly correlated with the electrical performance of 2D MoS2 FETs, providing practical guidelines to form van der Waals contacts.
- Published
- 2019
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29. P0614URINARY EXOSOMAL MICRORNA-21 AS A MARKER OF SCRUB TYPHUS-ASSOCIATED ACUTE KIDNEY INJURY
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A Young Cho, In O Sun, and Kwang Young Lee
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Transplantation ,Pathology ,medicine.medical_specialty ,business.industry ,Urinary system ,NGAL Protein ,Acute kidney injury ,Scrub typhus ,bacterial infections and mycoses ,urologic and male genital diseases ,medicine.disease ,Comorbidity ,female genital diseases and pregnancy complications ,Nephrology ,Diabetes mellitus ,microRNA ,Area under curve ,medicine ,business - Abstract
Background and Aims Urinary microRNA (miRNA)-21 is reported to be a biomarker for detection of acute kidney injury (AKI). Analysis of urinary exsome may serve as a novel diagnostic approach in kidney disease. The aim of this study is to investigate the clinical significance of urinary exosomal miRNA-21 for AKI in patients with scrub typhus. Method In a cross-sectional study, we collected 138 urine samples at the time of admission from 145 patients with scrub typhus. For 25 patients with scrub typhus-associated AKI and 25 age, sex-matched scrub typhus patient without AKI, we measured miRNA-21 in urinary exosomal fraction and compared diagnostic value in predictiong AKI. Results Compared with patients in the non-AKI group, patients in the AKI group were more likely to have one or more comorbidity such as diabetes (50% vs. 5%, P Conclusion Urinary exosomal miRNA-21 could be a surrogate markers for the diagnosis of scrub typhus–associated AKI.
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- 2020
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30. P0607CLINICAL SIGNIFICANCE OF HYPOALBUMINEMIA FOR ACUTE KIDNEY INJURY IN PATIENTS WITH SCRUB TYPHUS
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In O Sun and Kwang Young Lee
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Transplantation ,medicine.medical_specialty ,biology ,business.industry ,medicine.medical_treatment ,Serum albumin ,Acute kidney injury ,Serum Albumin Measurement ,Renal function ,Scrub typhus ,medicine.disease ,Gastroenterology ,Nephrology ,Internal medicine ,medicine ,biology.protein ,Hypoalbuminemia ,Leukocytosis ,Renal replacement therapy ,medicine.symptom ,business - Abstract
Background and Aims The aim of this study is to investigate the clinical significance of hypoalbuminemia (HA) for acute kidney injury (AKI) in patients with scrub typhus. Method From 2010 to 2017, 449 patients were diagnosed with scrub typhus. We divided the patients into two groups [normoalbuminemia (NA) vs. hypoalbuminemia (HA)] based on the serum albumin level of 3.5 g/dL, and compared the incidence, clinical characteristics, and severity of AKI based on RIFLE classification between two groups. Results Of the total 449 patients, 52 (11.6%) were categrized as HA group. Compared with patients in NA group, patients in HA group were older (74 ± 8 vs. 63 ± 13, P Conclusion Hypoabluminemia was closely associated with scrub typhus associated with AKI.
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- 2020
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31. Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study
- Author
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Eunjung Song, Da Bin Myung, Kyung-Tae Lee, Kwang Young Lee, Bo Hyung Kim, Kwang Hoon Lee, Yu Kyong Shin, Hye Shin Ahn, Sun Hee Lee, Jeong-Hun Lee, and Hee Soo Han
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0301 basic medicine ,Male ,Placebo-controlled study ,Administration, Oral ,Human skin ,Organism Hydration Status ,Hydrangea ,Gastroenterology ,Cutis Laxa ,skin elasticity ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Skin wrinkle ,Skin ,Nutrition and Dietetics ,biology ,integumentary system ,Hydrangea serrata ,skin wrinkle ,Middle Aged ,Skin texture ,Female ,lcsh:Nutrition. Foods and food supply ,Adult ,medicine.medical_specialty ,lcsh:TX341-641 ,Placebo ,Article ,03 medical and health sciences ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Elasticity (economics) ,skin hydration ,skin texture ,business.industry ,Plant Extracts ,clinical study ,biology.organism_classification ,Elasticity ,Skin Aging ,Plant Leaves ,030104 developmental biology ,Dietary Supplements ,skin roughness ,business ,Food Science ,Skin elasticity ,Phytotherapy - Abstract
Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1&ndash, R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.
- Published
- 2020
32. Use of protected zinc oxide in lower doses in weaned pigs in substitution for the conventional high dose zinc oxide
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In Ho Kim, Young Min Kim, Kwang Young Lee, and Santi Devi Upadhaya
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,Animal science ,Chemistry ,0402 animal and dairy science ,Weaning ,chemistry.chemical_element ,Animal Science and Zoology ,04 agricultural and veterinary sciences ,Zinc ,Body weight ,040201 dairy & animal science - Abstract
This study tested the hypothesis that protected zinc oxide (ZnO) in lower doses can substitute the high dose conventional ZnO in weaned pigs for improved growth performance and alleviation of digestive disorders. A total of 150 crossbred weaning pigs (28 days old) with an average body weight (BW) of 6.48 ± 1.58 kg were blocked and stratified based on sex and randomly allotted to 1 of 6 dietary treatments [5 pigs per pen (2 barrows and 3 gilts); 5 pens per treatment] for a 6-wk trial in two phases. Treatments consisted of basal diet (NC); Basal diet without Zn in mineral premix with either 2500 ppm unprotected ZnO (PC) or 250, 500, 750 and 1000 ppm protected ZnO (PZ1, PZ2, PZ3 and PZ4 respectively). As a result of this experiment, the growth performance in pigs fed protected ZnO diets was comparable with PC diet during phase 1 and 2, except for G/F ratio in phase 1. There were cubic effects (P In conclusion, a lower dose of protected ZnO could replace the higher dose of conventional ZnO because it has comparable or better effects than conventional ZnO in a higher dose.
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- 2018
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33. Peritoneal Dialysis-associated Peritonitis Caused by Chryseobacterium indologenes
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Kwang Young Lee, Jong Hwa Lee, Sung Sik Oh, Myung Woo Choi, In O Sun, Mi Rim Choi, and Hyun Ju Yang
- Subjects
0301 basic medicine ,medicine.medical_specialty ,business.industry ,Chryseobacterium indologenes ,medicine.medical_treatment ,030106 microbiology ,Peritonitis ,medicine.disease ,Gastroenterology ,Peritoneal dialysis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,business ,030217 neurology & neurosurgery - Published
- 2018
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34. Efficacy and Safety of CKD-11101 (Proposed Biosimilar of Darbepoetin-Alfa) Compared with Darbepoetin-Alfa in Patients on Hemodialysis: A Randomized, Double-Blinded, Parallel-Group Phase III Study
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Soo Wan Kim, Yaerim Kim, Dae Joong Kim, Yong-Lim Kim, Chang Hwa Lee, Sung Kwang Park, Kyubok Jin, Duk Hee Kang, Won Yong Cho, Kwon Wook Joo, Jin Kuk Kim, Kwang Young Lee, Joong Kyung Kim, Jun Young Do, Sug Kyun Shin, Jong Soo Lee, Wookyung Chung, Won Suk An, Kang Wook Lee, Su Kil Park, Dong Jin Oh, Gun Woo Kang, Sung Hyun Son, Jung Pyo Lee, and Jin Seok Jeon
- Subjects
Adult ,Male ,medicine.medical_specialty ,Randomization ,Darbepoetin alfa ,Drug-Related Side Effects and Adverse Reactions ,medicine.medical_treatment ,law.invention ,03 medical and health sciences ,Hemoglobins ,0302 clinical medicine ,Pharmacotherapy ,Randomized controlled trial ,Double-Blind Method ,law ,Renal Dialysis ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Renal Insufficiency, Chronic ,Adverse effect ,Biosimilar Pharmaceuticals ,030203 arthritis & rheumatology ,Pharmacology ,business.industry ,General Medicine ,Middle Aged ,Clinical trial ,Epoetin Alfa ,Erythropoietin ,030220 oncology & carcinogenesis ,Female ,Hemodialysis ,business ,Biotechnology ,medicine.drug - Abstract
Darbepoetin-alfa is an erythropoiesis-stimulating agent (ESA) with a long elimination half-life that achieves better hemoglobin (Hb) stability than short-acting ESAs. We aimed to evaluate the efficacy and safety of intravenous CKD-11101 (a biosimilar of darbepoetin-alfa) compared with those of darbepoetin-alfa in hemodialysis patients. The study was performed in 24 centers in Korea between June 2015 and June 2017. The study subjects were randomized in a double-blind manner. The follow-up duration was 24 weeks, which consisted of 20 weeks of maintenance and 4 weeks of evaluation period. All patients underwent a stabilization period to achieve a target baseline Hb of 10–12 g/dL before randomization. Following randomization, patients received darbepoetin-alfa or CKD-11101 weekly or biweekly. A total of 403 patients were randomized into two groups, and a total of 325 patients (80.6%) completed the investigation. The differences between the two groups in terms of change in the average Hb level from baseline to evaluation were not significant. The average administered dose of ESA was similar between the groups. There was no difference in the proportion of patients who maintained the target Hb during the evaluation period [60.4% vs. 66.2% in the CKD-11101 and darbepoetin-alfa groups, respectively (p = 0.3038)]. In addition, the safety analysis, consisting of adverse events and adverse drug reactions, showed comparable results between the two groups. The changes in the level of Hb, dose of erythropoietin, and achievement rate of the target Hb during the study period were comparable between the groups. CKD-11101 has an equivalent efficacy and safety compared with darbepoetin-alfa in patients undergoing hemodialysis.
- Published
- 2019
35. Metallic contact induced van der Waals gap in a MoS
- Author
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Changsik, Kim, Kwang Young, Lee, Inyong, Moon, Sudarat, Issarapanacheewin, and Won Jong, Yoo
- Abstract
Electrical metal contacts formed with 2D materials strongly affect device performance. Here, we used scanning transmission electron microscopy (STEM) and energy-dispersive spectroscopy (EDS) to characterize the interfacial structure formed and physical damage induced between MoS2 and the most commonly used metals, Ti, Cr, Au, and Pd. We further correlated the electrical performance with physical defects observed at the 2D interfacial structure. The contact resistances were higher in the order of Ti, Au, Pd, and Cr contacts, but all 4-point probe mobilities measured with metals in contact with identical quadrilayer MoS2 were ∼65 cm2 V-1 s-1, confirming the reliability of the devices. According to the STEM and EDS analyses, the Ti contact gave rise to a van der Waals gap between the clean quadrilayer MoS2 and the Ti contact. By contrast, Cr migrated into MoS2 while Mo and S counter-migrated into the SiO2 substrate. Au and Pd formed glassy layers that resulted in the migration of Mo and S into the Au and Pd electrodes. These interfacial structures between MoS2 and contact metals strongly correlated with the electrical performance of 2D MoS2 FETs, providing practical guidelines to form van der Waals contacts.
- Published
- 2019
36. SP243CLINICAL USEFULLNESS OF CONTRAST-ENHANCED COMPUTED TOMOGRAPHY IN PATIENTS WITH NONOBSTRUCTIVE ACUTE PYLEONEPHRITIS-ASSOCIATED ACUTE KIDNEY INJURY
- Author
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Mi-Suk Lee, A Young Cho, In O Sun, and Kwang Young Lee
- Subjects
Transplantation ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,media_common.quotation_subject ,Acute kidney injury ,Computed tomography ,medicine.disease ,Nephrology ,medicine ,Contrast (vision) ,In patient ,Radiology ,business ,media_common - Published
- 2019
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37. Elucidation of an intrinsic parameter for evaluating the electrical quality of graphene flakes
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Kwang Young Lee, Jong-Seong Bae, Ha-Jin Lee, Haeseong Lee, Ji Sun Kim, Mahfuza Mubarak, and Kyungho Park
- Subjects
0301 basic medicine ,Materials science ,Oxide ,lcsh:Medicine ,Conductivity ,Article ,law.invention ,03 medical and health sciences ,symbols.namesake ,chemistry.chemical_compound ,0302 clinical medicine ,X-ray photoelectron spectroscopy ,Electrical resistivity and conductivity ,law ,Composite material ,lcsh:Science ,Multidisciplinary ,Graphene ,lcsh:R ,Test method ,030104 developmental biology ,chemistry ,symbols ,lcsh:Q ,Raman spectroscopy ,030217 neurology & neurosurgery ,Order of magnitude - Abstract
A test method for evaluating the quality of graphene flakes, such as reduced graphene oxide (rGO) and graphene nanopowder (GNP), was developed in this study. The pelletizer was selected for a sampling tool, which enables us to formulate the flake sample as a measurable sample. Various parameters were measured from the pelletized sample in order to elucidate the best parameter for representing the quality of the graphene flakes in terms of their electrical properties. Based on the analysis of 4-probe measurement data on the pelletized sample, the best intrinsic parameter is volume resistivity (or volume conductivity) rather than resistivity (or conductivity). Additionally, the possible modification of a sample before and after the pressurization was investigated by electron microscopy and Raman spectroscopy. No significant modification was observed. The volume conductivity in the two types of the graphene was different from their individual conductivities by one order of magnitude. Based on the results of X-ray photoelectron spectroscopy and Raman spectroscopy measurements, the volume conductivity of the graphene flake samples was governed by the oxygen content in the sample. Our achievements will promote the effective use of powder-type graphene products for further applications.
- Published
- 2019
38. Comparison of clinical characteristics of patients with acute kidney injury after intravenous versus inhaled colistin therapy
- Author
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Jin Young Kwak, Hyun Ju Yoon, A Young Cho, Jung Cheol Lee, Kwang Young Lee, and In O Sun
- Subjects
0301 basic medicine ,medicine.medical_specialty ,lcsh:Internal medicine ,End of therapy ,lcsh:Specialties of internal medicine ,Urology ,medicine.medical_treatment ,030106 microbiology ,Disease ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,lcsh:RC581-951 ,Internal medicine ,medicine ,In patient ,030212 general & internal medicine ,Renal replacement therapy ,lcsh:RC31-1245 ,business.industry ,Colistin ,Mortality rate ,Incidence (epidemiology) ,Acute kidney injury ,Inhaler ,medicine.disease ,Surgery ,Nephrology ,Original Article ,business ,Intravenous ,medicine.drug - Abstract
Background The aim of this study was to investigate the incidence and clinical characteristics of intravenous (IV) or inhaled (IH) colistin-associated acute kidney injury (AKI) using the Risk, Injury, Failure, Loss, End-stage Renal Disease criteria. Methods From 2010 to 2014, 160 patients were treated with IV or IH colistin. Of these, we included 126 patients who received colistin for > 72 hours for the treatment of pneumonia and compared the incidence and clinical characteristics of patients in the IV (n = 107) and IH (n = 19) groups. Results The patients included 104 men and 22 women, with a mean age of 69 years (range, 24–91 years). The mortality rate was 45%, and AKI occurred in 75 (60%) patients. At the end of therapy, the bacteriologic cure rate was 66%. There were no differences in the clinical characteristics between the IV and IH groups except for age. In comparison with patients in the IV group, the patients in the IH group were older (74 ± 8 vs. 68 ± 12 years, P = 0.026). The incidence of AKI was not different between the 2 groups (62 vs. 47%, P = not significant), and there was no difference in the severity of AKI according to the Risk, Injury, Failure, Loss, End-stage Renal Disease criteria. Of the 83 patients with AKI, 6 and 1 patients underwent renal replacement therapy, respectively. Conclusion The incidence of AKI in patients with colistin therapy is 60% in our center. It seems that IH colistin therapy could not be better in safety than IV colistin therapy.
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- 2016
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39. Xunzi’s Theory of Mind from the Viewpoint of Metapraxis
- Author
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Kwang-Young Lee
- Subjects
Philosophy ,Theory of mind ,Epistemology - Published
- 2016
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40. Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study
- Author
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Byoung Geun Han, Hye Eun Yoon, Tae Won Lee, Yong-Soo Kim, Ki Ryang Na, Jong Tae Cho, Hyung Wook Kim, Jin Kuk Kim, Jong Hoon Chung, Kitae Bang, Young Rim Song, Seong Suk Kim, Yang Wook Kim, Young Joo Kwon, Ho Cheol Song, Jong Hyeok Jeong, Kyoung Hyoub Moon, Byung Soo Kim, Kwang Young Lee, Young Ok Kim, Sung Ro Yun, Yoon Kyung Chang, Chang Hwa Lee, Seok Joon Shin, and Eun Ah Hwang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pediatrics ,medicine.medical_treatment ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Gastroenterology ,Peritoneal dialysis ,03 medical and health sciences ,0302 clinical medicine ,Vascular Stiffness ,Quality of life ,Bioimpedance spectroscopy ,Internal medicine ,bioimpedance ,Medicine ,Humans ,quality of life ,fluid overload ,Hydration status ,Aged ,Heart Failure ,Dehydration ,business.industry ,overhydration ,General Medicine ,Middle Aged ,medicine.disease ,humanities ,Quartile ,peritoneal dialysis ,Heart failure ,Dielectric Spectroscopy ,Quality of Life ,Observational study ,Female ,Kidney Diseases ,business ,Kidney disease ,Research Paper - Abstract
Backgound: This study evaluated whether the hydration status affected health-related quality of life (HRQOL) during 12 months in peritoneal dialysis (PD) patients. Methods: The hydration status and the HRQOL were examined at baseline and after 12 months using a bioimpedance spectroscopy and Kidney Disease Quality of Life-Short Form, respectively in PD patients. Four hundred eighty-one patients were included and divided according to the baseline overhydration (OH) value; normohydration group (NH group, -2L≤ OH ≤+2L, n=266) and overhydration group (OH group, OH >+2L, n=215). Baseline HRQOL scores were compared between the two groups. The subjects were re-stratified into quartiles according to the OH difference (OH value at baseline - OH value at 12 months
- Published
- 2016
41. Synthesis and Characterisation of Porous Titania-Silica Composite Aerogel for NOx and Acetaldehyde Removal
- Author
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Geon Joong Kim, Mohammad Shahid, Se Min Park, Ibrahim El Saliby, Ho Kyong Shon, Kwang Young Lee, Jong Beom Kim, and Jong-Ho Kim
- Subjects
Morphology (linguistics) ,Materials science ,Composite number ,Biomedical Engineering ,Acetaldehyde ,Bioengineering ,Aerogel ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Polymer chemistry ,Photocatalysis ,General Materials Science ,Nitrogen oxide ,0210 nano-technology ,Porosity ,Ambient pressure - Abstract
In this study, the synthesis of porous titania-silica (TiO2-SiO2) composite aerogel at ambient pressure by using non-hazardous chemicals as a source of silica was investigated. TiO2-SiO2 composite aerogels were characterised and their photocatalytic performances were investigated for the removal efficiency of acetaldehyde and NO(x) under UV light. Results showed that porous composite aerogel with aggregated morphology, high surface area and an increased mesoporosity were formed. TiO2-SiO2(1.8) composite, with high Ti/Si ratio, showed the best results in terms of photocatalytic removal of acetaldehyde and nitrogen oxide.
- Published
- 2016
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42. Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis
- Author
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Cheol Whee Park, Jeong Ho Kim, Kwang Young Lee, Chul Woo Yang, Byung Ha Chung, Yong-Soo Kim, Hyun Ju Yoon, In O Sun, and Bum Soon Choi
- Subjects
medicine.medical_specialty ,lcsh:Internal medicine ,lcsh:Specialties of internal medicine ,Urology ,medicine.medical_treatment ,Peritoneal dialysis ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Gastroenterology ,Erythrocyte indices ,Red blood cell distributionwidth ,03 medical and health sciences ,0302 clinical medicine ,Red blood cell distribution width ,lcsh:RC581-951 ,Internal medicine ,medicine ,In patient ,Clinical significance ,lcsh:RC31-1245 ,business.industry ,Surgery ,Nephrology ,Original Article ,business - Abstract
Background: In this study, we assessed whether red blood cell distribution width (RDW) was associated with all-cause mortality in patients on peritoneal dialysis (PD) and evaluated its prognostic value. Methods: This study included 136 patients who had RDW levels at PD initiation from January 2007 to January 2014 at the Presbyterian Medical Center and Seoul St. Mary's Hospital. We divided these patients into 2 groups (survivors vs. non-survivors), compared their clinical characteristics, and analyzed the predictors of survival. Results: The study included 79 men and 57 women, with a mean age of 54 years (range, 15-85 years). The mean follow-up duration was 32 months (range, 1-80 months). Of 136 patients, 14 died during the follow-up period. When clinical characteristics of survivors (n = 122) and nonsurvivors (n = 14) were compared, no differences were identified, with the exception of serum albumin, total iron-binding capacity (TIBC), left ventricular ejection fraction, total leukocyte count, and RDW value. Survivors had higher serum albumin (3.4 +/- 0.5 vs. 3.0 +/- 0.5 g/dL, P < 0.001) and left ventricular ejection fraction (56.8 +/- 9.8 vs. 48.7 +/- 12.8, P = 0.040) and lower TIBC (213.4 +/- 40.9 vs. 252.8 +/- 65.6, P = 0.010), total leukocyte counts (6.9 +/- 10(3)/mu L vs. 8.6 x 10(3)/mu L, P = 0.009), and serum RDW values (13.9 +/- 1.7 vs. 16.0 +/- 1.8, P < 0.001). Patients with high RDW levels (>= 14.8) showed significantly higher all-cause mortality than patients with low RDW levels (< 14.8, P < 0.001). In multivariate-adjusted Cox analysis, RDW and TIBC at the start of PD were independent risk predictors for all-cause mortality. Conclusion: RDW could be an additive predictor for all-cause mortality in patients on PD. Copyright (C) 2016. The Korean Society of Nephrology. Published by Elsevier.
- Published
- 2016
43. High‐Electric‐Field‐Induced Phase Transition and Electrical Breakdown of MoTe 2
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Chang Sik Kim, Chang-Ho Ra, Won Jong Yoo, Sudarat Issarapanacheewin, Inyong Moon, Kwang Young Lee, Sung Won Lee, and Zheng Yang
- Subjects
Phase transition ,Materials science ,Condensed matter physics ,Electric field ,Electrical breakdown ,Dissipation ,Electronic, Optical and Magnetic Materials - Published
- 2020
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44. Dietary supplementation with protected calcium effects production and egg quality of Hy-line brown laying hens
- Author
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H. Shi, Kwang Young Lee, and I. H. Kim
- Subjects
Meal ,Animal science ,Chemistry ,Phosphorus ,chemistry.chemical_element ,Animal Science and Zoology ,Context (language use) ,Eggshell formation ,Eggshell ,Calcium ,Food Science ,Morning ,Bioavailability - Abstract
Context Currently, the commonly used dietary calcium sources are not sufficiently bioavailable to be used for eggshell formation or bone health in laying hens. Protected calcium, a blend of calcium and medium-chain fatty acids with matrix coating, may exert an effective absorption and metabolism ability for calcium consumption in the laying hen. Aims The present study was conducted to evaluate the effects of protected-calcium supplementation on egg production, egg quality, and serum calcium and phosphorus concentrations in laying hens. Methods In total, 144 Hy-line brown laying hens (25 weeks old) were randomly allotted to three treatments (8 replicates with 6 hens, 1 hen per cage) in a 10-week trial. Treatments consisted of corn–wheat–soybean meal-based basal diet with limestone (coarse limestone:fine limestone = 50:50) as a calcium source (CON) or basal diet supplemented with 0.5% (P1) or 1% (P2) protected calcium in substitution for an equal quantity of coarse limestone. Data were statistically analysed using linear and quadratic contrast with the GLM procedure of SAS. Probability values of
- Published
- 2020
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45. A Fermi-Level-Pinning-Free 1D Electrical Contact at the Intrinsic 2D MoS
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Zheng, Yang, Changsik, Kim, Kwang Young, Lee, Myeongjin, Lee, Samudrala, Appalakondaiah, Chang-Ho, Ra, Kenji, Watanabe, Takashi, Taniguchi, Kyeongjae, Cho, Euyheon, Hwang, James, Hone, and Won Jong, Yoo
- Abstract
Currently 2D crystals are being studied intensively for use in future nanoelectronics, as conventional semiconductor devices face challenges in high power consumption and short channel effects when scaled to the quantum limit. Toward this end, achieving barrier-free contact to 2D semiconductors has emerged as a major roadblock. In conventional contacts to bulk metals, the 2D semiconductor Fermi levels become pinned inside the bandgap, deviating from the ideal Schottky-Mott rule and resulting in significant suppression of carrier transport in the device. Here, MoS
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- 2018
46. Clinical characteristics of sepsis-induced acute kidney injury in patients undergoing continuous renal replacement therapy
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Kwang Young Lee, In O Sun, Hyun Ju Yoon, and A Young Cho
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Male ,medicine.medical_treatment ,continuous renal replacement therapy ,030232 urology & nephrology ,Comorbidity ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Critical Care and Intensive Care Medicine ,lcsh:RC870-923 ,sepsis ,chemistry.chemical_compound ,0302 clinical medicine ,Medicine ,Platelet ,Survivors ,APACHE ,Aged, 80 and over ,platelet ,Incidence ,Acute kidney injury ,Age Factors ,General Medicine ,Acute Kidney Injury ,Middle Aged ,Prognosis ,Intensive Care Units ,Treatment Outcome ,Nephrology ,Creatinine ,urine output ,Female ,Glomerular Filtration Rate ,medicine.medical_specialty ,Critical Illness ,Urology ,Sepsis ,03 medical and health sciences ,Renal Dialysis ,Humans ,In patient ,Renal replacement therapy ,Urine output ,Aged ,Proportional Hazards Models ,Retrospective Studies ,urogenital system ,business.industry ,Platelet Count ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,chemistry ,Clinical Study ,business - Abstract
Objective: The aim of this study was to investigate the clinical characteristics of sepsis-induced acute kidney injury (AKI) in patients undergoing continuous renal replacement therapy (CRRT). Methods: From 2011 to 2015, we enrolled 340 patients who were treated with CRRT for sepsis at the Presbyterian Medical Center. In all patients, CRRT was performed using the PRISMA platform. We divided these patients into two groups (survivors and non-survivors) according to the 28-day all-cause mortality. We compared clinical characteristics and analyzed the predictors of mortality. Results: The 28-day all-cause mortality was 62%. Survivors were younger than non-survivors and had higher platelet counts (178 ± 101 × 103/mL vs. 134 ± 84 × 103/mL, p 0.05 mL/kg/h (66% vs. 86%, p = .001) in the first day. In a multivariate logistic regression analysis, age, platelet count, RDW score, APACHE II score, serum creatinine level, and a urine output of
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- 2018
47. A Rare Case of Urinary Tract Infection Caused by Enterococcus hirae in an Elderly Man with Benign Prostate Hyperplasia
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Ju Hwan Oh, Kwang Young Lee, Young Suk Kim, In O Sun, and A Young Cho
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medicine.medical_specialty ,biology ,business.industry ,Urinary system ,General Engineering ,Hyperplasia ,medicine.disease ,biology.organism_classification ,Gastroenterology ,Enterococcus hirae ,Internal medicine ,Rare case ,medicine ,business ,Benign prostate ,Letter to the Editor - Published
- 2019
48. Prognostic Factors in Cholinesterase Inhibitor Poisoning
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Kwang Young Lee, In O Sun, and Hyun Ju Yoon
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Renal function ,Poison control ,Kidney ,Severity of Illness Index ,Young Adult ,Clinical Research ,Internal medicine ,Severity of illness ,Cholinesterases ,Humans ,Medicine ,Young adult ,Pancreas ,APACHE ,Aged ,Retrospective Studies ,Cholinesterase ,Aged, 80 and over ,biology ,business.industry ,Poisoning ,Retrospective cohort study ,Pneumonia ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,Hospitalization ,Bicarbonates ,Treatment Outcome ,medicine.anatomical_structure ,biology.protein ,Regression Analysis ,Female ,Cholinesterase Inhibitors ,business - Abstract
Background Organophosphates and carbamates are insecticides that are associated with high human mortality. The purpose of this study is to investigate the prognostic factors affecting survival in patients with cholinesterase inhibitor (CI) poisoning. Material/Methods This study included 92 patients with CI poisoning in the period from January 2005 to August 2013. We divided these patients into 2 groups (survivors vs. non-survivors), compared their clinical characteristics, and analyzed the predictors of survival. Results The mean age of the included patients was 56 years (range, 16–88). The patients included 57 (62%) men and 35 (38%) women. When we compared clinical characteristics between the survivor group (n=81, 88%) and non-survivor group (n=11, 12%), there were no differences in renal function, pancreatic enzymes, or serum cholinesterase level, except for serum bicarbonate level and APACHE II score. The serum bicarbonate level was lower in non-survivors than in survivors (12.45±2.84 vs. 18.36±4.73, P
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- 2015
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49. Acute interstitial nephritis induced by Solanum nigrum
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Yeong Jin Choi, Myung Woo Choi, A Young Cho, Mi Rim Choi, Jong Hwa Lee, In O Sun, Hyun Ju Yang, Kwang Young Lee, and Sung Sik Oh
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lcsh:Internal medicine ,medicine.medical_specialty ,lcsh:Specialties of internal medicine ,medicine.drug_class ,Urology ,030232 urology & nephrology ,Inflammation ,Solanum nigrum ,Solanum ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,lcsh:RC581-951 ,Internal medicine ,medicine ,Anticholinergic ,Corticosteroid ,Ingestion ,lcsh:RC31-1245 ,Acute interstitial nephritis ,biology ,business.industry ,Acute kidney injury ,food and beverages ,medicine.disease ,biology.organism_classification ,030205 complementary & alternative medicine ,Corticosteroid therapy ,Nephrology ,Immunology ,medicine.symptom ,business - Abstract
Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury and pathologically characterized by inflammatory infiltrate in the renal interstitium. Solanum nigrum (S. nigrum) is a medicinal plant member of the Solanaceae family. Although S. nigrum has been traditionally used to treat various ailments such as pain, inflammation, and fever, it has also been reported to have a toxic effect, resulting in anticholinergic symptoms. However, there have been no reports of AIN caused by S. nigrum. Here, we report the first case of biopsy-confirmed AIN after ingestion of S. nigrum. The patient was successfully treated using corticosteroid therapy.
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- 2016
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50. Severe Crescentic BK Nephropathy: A Case Report
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Byung Ha Chung, Chul Woo Yang, Min Kyung Yeo, In O Sun, Hyun Ju Yoon, Yeong Jin Choi, and Kwang Young Lee
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Transplantation ,medicine.medical_specialty ,business.industry ,General surgery ,Immunology ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,eye diseases ,humanities ,03 medical and health sciences ,0302 clinical medicine ,Bk nephropathy ,Medicine ,business - Abstract
Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Department of Pathology, Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Hyun Ju Yoon, M.D., In O Sun, M.D., Min Kyung Yeo, M.D., Byung Ha Chung, M.D., Yeong Jin Choi, M.D., Chul Woo Yang, M.D. and Kwang Young Lee, M.D.
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- 2016
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