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331 results on '"Lujan Barroso, Leila"'

1. Circadian clock gene variants and their link with chronotype, chrononutrition, sleeping patterns and obesity in the European prospective investigation into cancer and nutrition (EPIC) study

Author

Molina-Montes, Esther, Rodríguez-Barranco, Miguel, Ching-López, Ana, Artacho, Reyes, Huerta, José María, Amiano, Pilar, Lasheras, Cristina, Moreno-Iribas, Conchi, Jimenez-Zabala, Ana, Chirlaque, María-Dolores, Barricarte, Aurelio, Luján-Barroso, Leila, Agudo, Antonio, Jakszyn, Paula, Quirós, José Ramón, and Sánchez, María José

Published
2022
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4. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Clasen, Joanna L, Heath, Alicia K, Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C, Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B, Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C, Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J, and Muller, David C

Published
2021
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5. Associations between dietary amino acid intakes and blood concentration levels

Author

Iguacel, Isabel, Schmidt, Julie A., Perez-Cornago, Aurora, Van Puyvelde, Heleen, Travis, Ruth, Stepien, Magdalena, Scalbert, Augustin, Casagrande, Corinne, Weiderpass, Elisabete, Riboli, Elio, Schulze, Matthias B., Skeie, Guri, Bodén, Stina, Boeing, Heiner, Cross, Amanda J., Harlid, Sophia, Jensen, Torill Enget, Huerta, José M., Katzke, Verena, Kühn, Tilman, Lujan-Barroso, Leila, Masala, Giovanna, Rodriguez-Barranco, Miguel, Rostgaard-Hansen, Agnetha Linn, van der Schouw, Yvonne T., Vermeulen, Roel, Tagliabue, Giovanna, Tjønneland, Anne, Trevisan, Morena, Ferrari, Pietro, Gunter, Marc J., and Huybrechts, Inge

Published
2021
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6. Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Lujan-Barroso, Leila, Achaintre, David, Franceschi, Silvia, Kyrø, Cecilie, Overvad, Kim, Tjønneland, Anne, Truong, Therese, Lecuyer, Lucie, Boutron-Ruault, Marie-Christine, Katzke, Verena, Johnson, Theron S, Schulze, Matthias B, Trichopoulou, Antonia, Peppa, Eleni, La Vechia, Carlo, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Skeie, Guri, Quirós, J Ramón, Rodriguez-Barranco, Miguel, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Almquist, Martin, Hennings, Joakim, Vermeulen, Roel, Wareham, Nicholas J, Tong, Tammy YN, Aune, Dagfinn, Byrnes, Graham, Weiderpass, Elisabete, Scalbert, Augustin, Rinaldi, Sabina, and Agudo, Antonio

Published
2021
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7. Should workers be physically active after work? Associations of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels—An individual participant data meta-analysis

Author

Cillekens, Bart, Coenen, Pieter, Huysmans, Maaike A., Holtermann, Andreas, Troiano, Richard P., Mork, Paul Jarle, Krokstad, Steinar, Clays, Els, De Bacquer, Dirk, Aadahl, Mette, Kårhus, Line Lund, Sjøl, Anette, Bo Andersen, Lars, Kauhanen, Jussi, Voutilainen, Ari, Pulsford, Richard, Stamatakis, Emmanuel, Goldbourt, Uri, Peters, Annette, Thorand, Barbara, Rosengren, Annika, Björck, Lena, Sprow, Kyle, Franzon, Kristin, Rodriguez-Barranco, Miguel, Luján-Barroso, Leila, Alfredsson, Lars, Bahls, Martin, Ittermann, Till, Wanner, Miriam, Bopp, Matthias, Marott, Jacob Louis, Schnohr, Peter, Nordestgaarda, Børge G., Dalene, Knut Eirik, Ekelund, Ulf, Clausen, Johan, Jensen, Magnus T., Petersen, Christina Bjørk, Krause, Niklas, Twisk, Jos, van Mechelen, Willem, and van der Beek, Allard J.

Published
2025
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8. Associations of occupational and leisure-time physical activity with all-cause mortality : an individual participant data meta-analysis

Author

Coenen, Pieter, Huysmans, Maaike A., Holtermann, Andreas, Troiano, Richard P., Mork, Paul Jarle, Krokstad, Steinar, Clays, Els, Cillekens, Bart, De Bacquer, Dirk, Aadahl, Mette, Karhus, Line Lund, Sjol, Anette, Andersen, Lars Bo, Kauhanen, Jussi, Voutilainen, Ari, Pulsford, Richard M., Stamatakis, Emmanuel, Goldbourt, Uri, Peters, Annette, Thorand, Barbara, Rosengren, Annika, Bjoerck, Lena, Sprow, Kyle, Franzon, Kristin, Rodriguez-Barranco, Miguel, Lujan-Barroso, Leila, Knutsson, Anders, Alfredsson, Lars, Bahls, Martin, Ittermann, Till, Kluttig, Alexander, Hassan, Lamiaa, Wanner, Miriam, Bopp, Matthias, Marott, Jacob Louis, Schnohr, Peter, Nordestgaard, Borge Gronne, Dalene, Knut Eirik, Ekelund, Ulf, Clausen, Johan, Jensen, Magnus Thorsten, Petersen, Christina Bjork, Krause, Niklas, Twisk, Jos, Mechelen, Willem van, van der Beek, Allard J., Coenen, Pieter, Huysmans, Maaike A., Holtermann, Andreas, Troiano, Richard P., Mork, Paul Jarle, Krokstad, Steinar, Clays, Els, Cillekens, Bart, De Bacquer, Dirk, Aadahl, Mette, Karhus, Line Lund, Sjol, Anette, Andersen, Lars Bo, Kauhanen, Jussi, Voutilainen, Ari, Pulsford, Richard M., Stamatakis, Emmanuel, Goldbourt, Uri, Peters, Annette, Thorand, Barbara, Rosengren, Annika, Bjoerck, Lena, Sprow, Kyle, Franzon, Kristin, Rodriguez-Barranco, Miguel, Lujan-Barroso, Leila, Knutsson, Anders, Alfredsson, Lars, Bahls, Martin, Ittermann, Till, Kluttig, Alexander, Hassan, Lamiaa, Wanner, Miriam, Bopp, Matthias, Marott, Jacob Louis, Schnohr, Peter, Nordestgaard, Borge Gronne, Dalene, Knut Eirik, Ekelund, Ulf, Clausen, Johan, Jensen, Magnus Thorsten, Petersen, Christina Bjork, Krause, Niklas, Twisk, Jos, Mechelen, Willem van, and van der Beek, Allard J.

Abstract

Objective Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed independent associations of occupational and leisure-time physical activity (OPA and LTPA) with all-cause mortality.Design Two-stage individual participant data meta-analysis.Data source Published and unpublished cohort study data.Eligibility criteria Working participants aged 18-65 years.Methods After data harmonisation, we assessed associations of OPA and LTPA with all-cause mortality. In stage 1, we analysed data from each study separately using Cox survival regression, and in stage 2, we pooled individual study findings with random-effects modelling.Results In 22 studies with up to 590 497 participants from 11 countries, during a mean follow-up of 23.1 (SD: 6.8) years, 99 743 (16%) participants died. Adjusted for LTPA, body mass index, age, smoking and education level, summary (ie, stage 2) hazard ration (HRs) and 95% confidence interval (95% CI) for low, moderate and high OPA among men (n=2 96 134) were 1.01 (0.99 to 1.03), 1.05 (1.01 to 1.10) and 1.12 (1.03 to 1.23), respectively. For women (n=2 94 364), HRs (95% CI) were 0.98 (0.92 to 1.04), 0.96 (0.92 to 1.00) and 0.97 (0.86 to 1.10), respectively. In contrast, higher levels of LTPA were inversely associated with mortality for both genders. For example, for women HR for low, moderate and high compared with sedentary LTPA were 0.85 (0.81 to 0.89), 0.78 (0.74 to 0.81) and 0.75 (0.65 to 0.88), respectively. Effects were attenuated when adjusting for income (although data on income were available from only 9 and 6 studies, for men and women, respectively).Conclusion Our findings indicate that OPA may not result in the same beneficial health effects as LTPA.

Published
2024
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9. Nitrosyl-heme and Heme Iron Intake from Processed Meats and Risk of Colorectal Cancer in the EPIC-Spain Cohort

Author

Rizzolo-Brime, Lucía, primary, Lujan-Barroso, Leila, additional, Farran-Codina, Andreu, additional, Bou, Ricard, additional, Lasheras, Cristina, additional, Amiano, Pilar, additional, Aizpurua, Amaia, additional, Sánchez, Maria-Jose, additional, Molina-Montes, Esther, additional, Guevara, Marcela, additional, Moreno-Iribas, Conchi, additional, Gasque, Alba, additional, Chirlaque-López, María Dolores, additional, Colorado-Yohar, Sandra M., additional, Huerta, José María, additional, Zamora-Ros, Raul, additional, Agudo, Antonio, additional, and Jakszyn, Paula, additional

Published
2024
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12. Development and validation of circulating CA125 prediction models in postmenopausal women

Author

Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A., Fortner, Renée T., Vitonis, Allison F., Yamamoto, Hidemi, Fichorova, Raina N., Titus, Linda J., Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Gram, Inger T., Quirós, J. Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J., Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W., Tworoger, Shelley S., and Terry, Kathryn L.

Published
2019
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13. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition

Author

Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-de-Mesquita, H Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni-Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H, Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J Ramón, Luján-Barroso, Leila, Sánchez, María-José, Chilarque, Maria-Dolores, Ardanas, Eva, Dorronsoro, Miren, Nilsson, Lena Maria, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E, Khaw, Kay-Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J, Riboli, Elio, Boeing, Heiner, and Trichopoulos, Dimitrios

Published
2015
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14. Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Author

Obón-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Cadeau, Claire, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Fortner, Renée T., Boeing, Heiner, Ramón Quirós, J., Molina-Montes, Esther, Chamosa, Saioa, Castaño, José María Huerta, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick, Key, Tim, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, De Magistris, Maria Santucci, Bueno-de-Mesquita, H. B., Peeters, Petra H., Wennberg, Maria, Bergdahl, Ingvar A., Vesper, Hubert, Riboli, Elio, and Duell, Eric J.

Published
2017
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15. Breakfast Size and Prevalence of Metabolic Syndrome in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish Cohort

Author

Lujan-Barroso, Leila, primary, Iglesias, Lucia, additional, Zamora-Ros, Raúl, additional, Lasheras, Cristina, additional, Sánchez, María-José, additional, Cabrera-Castro, Natalia, additional, Delfrad, Josu, additional, Amiano, Pilar, additional, Molina-Montes, Esther, additional, Colorado-Yohar, Sandra, additional, Moreno-Iribas, Conchi, additional, Dorronsoro, Ane, additional, Rodríguez-Barranco, Miguel, additional, Chirlaque, María Dolores, additional, Aizpurua, Amaia, additional, Agudo, Antonio, additional, Quirós, José Ramón, additional, and Jakszyn, Paula, additional

Published
2023
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16. Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Lujan-Barroso, Leila, González, Carlos Alberto, Slimani, Nadia, Obón-Santacana, Mireia, Ferrari, Pietro, Freisling, Heinz, Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Racine, Antoine, Katzke, Verena, Kühn, Tilman, Tjønneland, Anne, Olsen, Anja, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Amiano, Pilar, Navarro, Carmen, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Trichopoulou, Antonia, Bamia, Christina, Benetou, Vassiliki, Saieva, Calogero, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra H., Ericson, Ulrika, Wirfält, Elisabet, Sund, Malin, Johansson, Mattias, Weiderpass, Elisabete, Skeie, Guri, Riboli, Elio, Boeing, Heiner, and Duell, Eric J.

Published
2014

17. Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Hosnijeh, Fatemeh Saberi, Christopher, Yvette, Peeters, Petra, Romieu, Isabelle, Xun, Wei, Riboli, Elio, Raaschou-Nielsen, Ole, Tjønneland, Anne, Becker, Nikolaus, Nieters, Alexandra, Trichopoulou, Antonia, Bamia, Christina, Orfanos, Philip, Oddone, Enrico, Luján-Barroso, Leila, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Molina-Montes, Esther, Wareham, Nick, Vineis, Paolo, and Vermeulen, Roel

Published
2013
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18. Hepcidin levels and gastric cancer risk in the EPIC-EurGast study

Author

Jakszyn, Paula, Fonseca-Nunes, Ana, Lujan-Barroso, Leila, Aranda, Núria, Tous, Mónica, Arija, Victoria, Cross, Amanda, Bueno-de-Mesquita, B(as) H., Weiderpass, Elisabete, Kühn, Tilman, Kaaks, Rudolf, Sjöberg, Klas, Ohlsson, Bodil, Tumino, Rosario, Palli, Domenico, Ricceri, Fulvio, Fasanelli, Francesca, Krogh, Vittorio, Mattiello, Amalia, Jenab, Mazda, Gunter, Marc, Perez-Cornago, Aurora, Khaw, Kay-Tee, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Trichopoulou, Antonia, Peppa, Eleni, Vasilopoulou, Effie, Boeing, Heiner, Sánchez-Cantalejo, Emilio, Huerta, José María, Dorronsoro, Miren, Barricarte, Aurelio, Quirós, José Maria, Peeters, Petra H., and Agudo, Antonio

Published
2017
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19. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study

Author

Duell, Eric J., Lujan-Barroso, Leila, Sala, Núria, McElyea, Samantha Deitz, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Weiderpass, Elisabete, Busund, Lill-Tove, Moi, Line, Muller, David, Vineis, Paolo, Aune, Dagfinn, Matullo, Giuseppe, Naccarati, Alessio, Panico, Salvatore, Tagliabue, Giovanna, Tumino, Rosario, Palli, Domenico, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Bueno-de-Mesquita, B(as) H., Peeters, Petra H., Trichopoulou, Antonia, Lagiou, Pagona, Kotanidou, Anastasia, Travis, Ruth C., Wareham, Nick, Khaw, Kay-Tee, Quiros, Jose Ramon, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, María-Dolores, Ardanaz, Eva, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Brennan, Paul, Gunter, Marc, Scelo, Ghislaine, Cote, Greg, Sherman, Stuart, and Korc, Murray

Published
2017
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21. Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Zamora-Ros, Raul, Agudo, Antonio, Luján-Barroso, Leila, Romieu, Isabelle, Ferrari, Pietro, Knaze, Viktoria, Bueno-de-Mesquita, H Bas, Leenders, Max, Travis, Ruth C, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Slimani, Nadia, Scalbert, Augustin, Fedirko, Veronika, Hjartåker, Anette, Engeset, Dagrun, Skeie, Guri, Boeing, Heiner, Förster, Jana, Li, Kuanrong, Teucher, Birgit, Agnoli, Claudia, Tumino, Rosario, Mattiello, Amalia, Saieva, Calogero, Johansson, Ingegerd, Stenling, Roger, Redondo, Maria Luisa, Wallström, Peter, Ericson, Ulrika, Khaw, Kay-Tee, Mulligan, Angela A, Trichopoulou, Antonia, Dilis, Vardis, Katsoulis, Michael, Peeters, Petra HM, Igali, Lazslo, Tjønneland, Anne, Halkjær, Jytte, Touillaud, Marina, Perquier, Florence, Fagherazzi, Guy, Amiano, Pilar, Ardanaz, Eva, Bredsdorff, Lea, Overvad, Kim, Ricceri, Fulvio, Riboli, Elio, and González, Carlos A

Published
2012
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22. Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition

Author

Dahm, Christina C, Gorst-Rasmussen, Anders, Crowe, Francesca L, Roswall, Nina, Tjønneland, Anne, Drogan, Dagmar, Boeing, Heiner, Teucher, Birgit, Kaaks, Rudolf, Adarakis, George, Zylis, Dimosthenes, Trichopoulou, Antonia, Fedirko, Veronika, Chajes, Veronique, Jenab, Mazda, Palli, Domenico, Pala, Valeria, Tumino, Rosario, Ricceri, Fulvio, van Kranen, Henk, Bueno-de-Mesquita, H Bas, Quirós, Jose R, Sánchez, María-José, Luján-Barroso, Leila, Larrañaga, Nerea, Chirlaque, María-Dolores, Ardanaz, Eva, Johansson, Mattias, Stattin, Pär, Khaw, Kay-Tee, Wareham, Nick, Wark, Petra A, Norat, Teresa, Riboli, Elio, Key, Tim J, and Overvad, Kim

Published
2012
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23. A dietary pattern derived to predict estrogen levels and endometrial cancer risk

Author

Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Institut Català d'Oncologia, Crous Bou, Marta, Lujan Barroso, Leila, Pérez Casany, Marta, Madrero Pardo, Alba, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Institut Català d'Oncologia, Crous Bou, Marta, Lujan Barroso, Leila, Pérez Casany, Marta, and Madrero Pardo, Alba

Abstract

Aquest treball es basa en dues hipòtesis: Algunes dietes poden augmentar els nivells d'estrògens en sang, i alguns patrons dietètics relacionats amb els estrògens poden augmentar el risc de càncer d'endometri. Per a comprovar aquestes hipòtesis, hem creat un patró dietètic correlacionat amb els nivells d'estrògens mitjançant el mètode del Reduced rank regression (RRR). A posteriori, hem estudiat l'associació entre aquest patró i el risc de càncer d'endometri utilitzant Cox models. Hem vist que una dieta rica en llegums, làctics i cervesa, i baixa en cereals i llegums, està associada a menors nivells de estrògens. També hem observat una lleu associació entre el nostre patró i els risc de càncer d'endometri.

Published
2022

24. Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author

Duell, Eric J, Travier, Noémie, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, J Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E, Key, Timothy J, Bueno-de-Mesquita, H Bas, Ros, Martine M, Numans, Mattijs E, Peeters, Petra HM, Trichopoulou, Antonia, Naska, Androniki, Dilis, Vardis, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Schütze, Madlen, Regner, Sara, Lindkvist, Björn, Johansson, Ingegerd, Hallmans, Göran, Overvad, Kim, Egeberg, Rikke, Tjønneland, Anne, Lund, Eiliv, Weiderpass, Elisabete, Braaten, Tonje, Romieu, Isabelle, Ferrari, Pietro, Jenab, Mazda, Stenling, Roger, Aune, Dagfinn, Norat, Teresa, Riboli, Elio, and González, Carlos A

Published
2011
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25. Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in nonsmoking postmenopausal women from the EPIC cohort

Author

Obón-Santacana, Mireia, Freisling, Heinz, Peeters, Petra H., Lujan-Barroso, Leila, Ferrari, Pietro, Boutron-Ruault, Marie-Christine, Mesrine, Sylvie, Baglietto, Laura, Turzanski-Fortner, Renee, Katzke, Verena A., Boeing, Heiner, Quirós, Ramón J., Molina-Portillo, Elena, Larrañaga, Nerea, Chirlaque, María-Dolores, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Merritt, Melissa A., Gunter, Marc J., Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Fiano, Valentina, Galassom, Rocco, Bueno-de-Mesquita, H. B(as), Onland-Moret, Charlotte N., Idahl, Annika, Lundin, Eva, Weiderpass, Elisabete, Vesper, Hubert, Riboli, Elio, and Duell, Eric J.

Published
2016
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26. Challenges in estimating the validity of dietary acrylamide measurements

Author

Ferrari, Pietro, Freisling, Heinz, Duell, Eric J., Kaaks, Rudolf, Lujan-Barroso, Leila, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Nailler, Laura, Polidoro, Silvia, Mattiello, Amalia, Palli, Domenico, Tumino, Rosario, Grioni, Sara, Knüppel, Sven, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Orfanos, Philippos, Katsoulis, Michail, Trichopoulou, Antonia, Quirós, Jose Ramón, Ardanaz, Eva, Huerta, José María, Etxezarreta, Pilar Amiano, Sánchez, María José, Crowe, Francesca, Khaw, Kay-Tee, Wareham, Nicholas J., Ocke, Marga, Bueno-de-Mesquita, Bas, Peeters, Petra H. M., Ericson, Ulrika, Wirfält, Elisabet, Hallmans, Göran, Johansson, Ingegerd, Engeset, Dagrun, Nicolas, Geneviève, Gallo, Valentina, Norat, Teresa, Riboli, Elio, and Slimani, Nadia

Published
2013
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27. Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population

Author

Duell, Eric J., Bonet, Catalina, Muñoz, Xavier, Lujan-Barroso, Leila, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Racine, Antoine, Severi, Gianluca, Canzian, Federico, Rizzato, Cosmeri, Boeing, Heiner, Overvad, Kim, Tjnneland, Anne, Argüelles, Marcial, Sánchez-Cantalejo, Emilio, Chamosa, Saioa, Huerta, José María, Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick, Travis, Rutch C., Trichopoulou, Antonia, Trichopoulos, Dimitrios, Yiannakouris, Nikos, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Bueno-de-Mesquita, B(as) H, Siersema, Peter D., Peeters, Petra H.M., Ohlsson, Bodil, Lindkvist, Björn, Johansson, Ingegerd, Ye, Weimin, Johansson, Matthias, Fenger, Claus, Riboli, Elio, Sala, Núria, and González, Carlos A.

Published
2015
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28. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer : a pooled analysis of data from two prospective cohort studies

Author

Jayasekara, Harindra, MacInnis, Robert J., Lujan-Barroso, Leila, Mayen-Chacon, Ana-Lucia, Cross, Amanda J., Wallner, Bengt, Palli, Domenico, Ricceri, Fulvio, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Kühn, Tilman, Kaaks, Rudolf, Tsilidis, Kostas, Sánchez, Maria-Jose, Amiano, Pilar, Ardanaz, Eva, Chirlaque López, María Dolores, Merino, Susana, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Severi, Gianluca, Sternby, Hanna, Sonestedt, Emily, Bueno-de-Mesquita, Bas, Boeing, Heiner, Travis, Ruth, Sandanger, Torkjel M., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Tjønneland, Anne, Yang, Yi, Hodge, Allison M., Mitchell, Hazel, Haydon, Andrew, Room, Robin, Hopper, John L., Weiderpass, Elisabete, Gunter, Marc J., Riboli, Elio, Giles, Graham G., Milne, Roger L., Agudo, Antonio, English, Dallas R., Ferrari, Pietro, Jayasekara, Harindra, MacInnis, Robert J., Lujan-Barroso, Leila, Mayen-Chacon, Ana-Lucia, Cross, Amanda J., Wallner, Bengt, Palli, Domenico, Ricceri, Fulvio, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Kühn, Tilman, Kaaks, Rudolf, Tsilidis, Kostas, Sánchez, Maria-Jose, Amiano, Pilar, Ardanaz, Eva, Chirlaque López, María Dolores, Merino, Susana, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Severi, Gianluca, Sternby, Hanna, Sonestedt, Emily, Bueno-de-Mesquita, Bas, Boeing, Heiner, Travis, Ruth, Sandanger, Torkjel M., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Tjønneland, Anne, Yang, Yi, Hodge, Allison M., Mitchell, Hazel, Haydon, Andrew, Room, Robin, Hopper, John L., Weiderpass, Elisabete, Gunter, Marc J., Riboli, Elio, Giles, Graham G., Milne, Roger L., Agudo, Antonio, English, Dallas R., and Ferrari, Pietro

Abstract

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.

Published
2021
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29. Soft drink and juice consumption and renal cell carcinoma incidence and mortality in the european prospective investigation into cancer and nutrition

Author

Heath, Alicia K., Clasen, Joanna L., Jayanth, Nick P., Jenab, Mazda, Tjønneland, Anne, Petersen, Kristina Elin Nielsen, Overvad, Kim, Srour, Bernard, Katzke, Verena, Bergmann, Manuela M., Schulze, Matthias B., Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Catalano, Alberto, Pasanisi, Fabrizio, Brustad, Magritt, Standahl Olsen, Karina, Skeie, Guri, Lujan-Barroso, Leila, Rodríguez-Barranco, Miguel, Amiano, Pilar, Santiuste, Carmen, Barricarte Gurrea, Aurelio, Axelson, Hakan, Ramne, Stina, Ljungberg, Börje, Watts, Eleanor L., Huybrechts, Inge, Weiderpass, Elisabete, Riboli, Elio, Muller, David C., Heath, Alicia K., Clasen, Joanna L., Jayanth, Nick P., Jenab, Mazda, Tjønneland, Anne, Petersen, Kristina Elin Nielsen, Overvad, Kim, Srour, Bernard, Katzke, Verena, Bergmann, Manuela M., Schulze, Matthias B., Masala, Giovanna, Krogh, Vittorio, Tumino, Rosario, Catalano, Alberto, Pasanisi, Fabrizio, Brustad, Magritt, Standahl Olsen, Karina, Skeie, Guri, Lujan-Barroso, Leila, Rodríguez-Barranco, Miguel, Amiano, Pilar, Santiuste, Carmen, Barricarte Gurrea, Aurelio, Axelson, Hakan, Ramne, Stina, Ljungberg, Börje, Watts, Eleanor L., Huybrechts, Inge, Weiderpass, Elisabete, Riboli, Elio, and Muller, David C.

Abstract

Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults, and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases, including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 389,220 EPIC participants with median age of 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially sweetened soft drinks. Results: A total of 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment ¼ 1.03; 95% CI, 0.97-1.09), total soft drinks (HR ¼ 1.01; 95% CI, 0.98-1.05), sugar-sweetened soft drinks (HR ¼ 0.99; 95% CI, 0.94-1.05), or artificially sweetened soft drinks (HR ¼ 1.02; 95% CI, 0.96-1.08). In these fully adjusted models, none of the beverages was associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively). Conclusions: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity. Impact: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.

Published
2021
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30. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer:A pooled analysis of data from two prospective cohort studies

Author

Jayasekara, Harindra, MacInnis, Robert J., Lujan-Barroso, Leila, Mayen-Chacon, Ana-Lucia, Cross, Amanda J., Wallner, Bengt, Palli, Domenico, Ricceri, Fulvio, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Kuehn, Tilman, Kaaks, Rudolf, Tsilidis, Kostas, Sanchez, Maria-Jose, Amiano, Pilar, Ardanaz, Eva, Chirlaque Lopez, Maria Dolores, Merino, Susana, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Severi, Gianluca, Sternby, Hanna, Sonestedt, Emily, Bueno-de-Mesquita, Bas, Boeing, Heiner, Travis, Ruth, Sandanger, Torkjel M., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Tjonneland, Anne, Yang, Yi, Hodge, Allison M., Mitchell, Hazel, Haydon, Andrew, Room, Robin, Hopper, John L., Weiderpass, Elisabete, Gunter, Marc J., Riboli, Elio, Giles, Graham G., Milne, Roger L., Agudo, Antonio, English, Dallas R., Ferrari, Pietro, Jayasekara, Harindra, MacInnis, Robert J., Lujan-Barroso, Leila, Mayen-Chacon, Ana-Lucia, Cross, Amanda J., Wallner, Bengt, Palli, Domenico, Ricceri, Fulvio, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Kuehn, Tilman, Kaaks, Rudolf, Tsilidis, Kostas, Sanchez, Maria-Jose, Amiano, Pilar, Ardanaz, Eva, Chirlaque Lopez, Maria Dolores, Merino, Susana, Rothwell, Joseph A., Boutron-Ruault, Marie-Christine, Severi, Gianluca, Sternby, Hanna, Sonestedt, Emily, Bueno-de-Mesquita, Bas, Boeing, Heiner, Travis, Ruth, Sandanger, Torkjel M., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Tjonneland, Anne, Yang, Yi, Hodge, Allison M., Mitchell, Hazel, Haydon, Andrew, Room, Robin, Hopper, John L., Weiderpass, Elisabete, Gunter, Marc J., Riboli, Elio, Giles, Graham G., Milne, Roger L., Agudo, Antonio, English, Dallas R., and Ferrari, Pietro

Abstract

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for >= 60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (P-homogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.

Published
2021

31. Associations between dietary amino acid intakes and blood concentration levels

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Planetary Health & Exposoom, Cancer, Iguacel, Isabel, Schmidt, Julie A., Perez-Cornago, Aurora, Van Puyvelde, Heleen, Travis, Ruth, Stepien, Magdalena, Scalbert, Augustin, Casagrande, Corinne, Weiderpass, Elisabete, Riboli, Elio, Schulze, Matthias B., Skeie, Guri, Bodén, Stina, Boeing, Heiner, Cross, Amanda J., Harlid, Sophia, Jensen, Torill Enget, Huerta, José M., Katzke, Verena, Kühn, Tilman, Lujan-Barroso, Leila, Masala, Giovanna, Rodriguez-Barranco, Miguel, Rostgaard-Hansen, Agnetha Linn, van der Schouw, Yvonne T., Vermeulen, Roel, Tagliabue, Giovanna, Tjønneland, Anne, Trevisan, Morena, Ferrari, Pietro, Gunter, Marc J., Huybrechts, Inge, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Planetary Health & Exposoom, Cancer, Iguacel, Isabel, Schmidt, Julie A., Perez-Cornago, Aurora, Van Puyvelde, Heleen, Travis, Ruth, Stepien, Magdalena, Scalbert, Augustin, Casagrande, Corinne, Weiderpass, Elisabete, Riboli, Elio, Schulze, Matthias B., Skeie, Guri, Bodén, Stina, Boeing, Heiner, Cross, Amanda J., Harlid, Sophia, Jensen, Torill Enget, Huerta, José M., Katzke, Verena, Kühn, Tilman, Lujan-Barroso, Leila, Masala, Giovanna, Rodriguez-Barranco, Miguel, Rostgaard-Hansen, Agnetha Linn, van der Schouw, Yvonne T., Vermeulen, Roel, Tagliabue, Giovanna, Tjønneland, Anne, Trevisan, Morena, Ferrari, Pietro, Gunter, Marc J., and Huybrechts, Inge

Published
2021

32. Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author

Duell, Eric J., Travier, Noémie, Lujan-Barroso, Leila, Dossus, Laure, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Tumino, Rosario, Masala, Giovanna, Krogh, Vittorio, Panico, Salvatore, Ricceri, Fulvio, Redondo, Maria Luisa, Dorronsoro, Miren, Molina-Montes, Esther, Huerta, José M., Barricarte, Aurelio, Khaw, Kay-Tee, Wareham, Nick J., Allen, Naomi E., Travis, Ruth, Siersema, Peter D., Peeters, Petra H.M., Trichopoulou, Antonia, Fragogeorgi, Eirini, Oikonomou, Eleni, Boeing, Heiner, Schuetze, Madlen, Canzian, Federico, Lukanova, Annekatrin, Tjnneland, Anne, Roswall, Nina, Overvad, Kim, Weiderpass, Elisabete, Gram, Inger Torhild, Lund, Eiliv, Lindkvist, Björn, Johansen, Dorthe, Ye, Weimin, Sund, Malin, Fedirko, Veronika, Jenab, Mazda, Michaud, Dominique S., Riboli, Elio, and Bueno-de-Mesquita, Bas H.

Published
2013
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33. Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up

Author

Gonzalez, Carlos A., Lujan-Barroso, Leila, Bueno-de-Mesquita, H. B(as)., Jenab, Mazda, Duell, Eric J., Agudo, Antonio, Tjnneland, Anne, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Françoise, Touillaud, Marina, Teucher, Birgit, Kaaks, Rudolf, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Roukos, Dimitrios, Karapetyan, Tina, Palli, Domenico, Tagliabue, Giovanna, Mattiello, Amalia, Tumino, Rosario, Ricceri, Fulvio, Siersema, Peter D., Numans, Mattijs E., Peeters, Petra P.H., Parr, Christine L., Skeie, Guri, Lund, Eiliv, Quirós, J. Ramón, Sánchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Ehrnström, Roy, Regner, Sara, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Crowe, Francesca L., Blaker, Hendrik, Romieu, Isabelle, and Riboli, Elio

Published
2012
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34. Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study

Author

Jakszyn, Paula, Agudo, Antonio, Lujan-Barroso, Leila, Bueno-de-Mesquita, H Bas, Jenab, Mazda, Navarro, Carmen, Palli, Domenico, Boeing, Heiner, Manjer, Jonas, Numans, Mattijs E, Igali, Laszlo, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Grioni, Sara, Panico, cSalvatore, Tumino, Rosario, Sacerdote, Carlotta, Quirós, Ramon J., Molina-Montes, Esther, Ma Huerta Castaño, Jose, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Key, Timothy J, Jeurnink, Suzanne M., Peeters, Petra HM, Bamia, Christina, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova, Annekatrin, Bergmann, Manuela M., Lindkvist, Björn, Stenling, Roger, Johansson, Ingegerd, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Skeie, Guri, Ragnhild Broderstad, Ann, Lund, Eiliv, Michaud, Dominique S., Mouw, Traci, Riboli, Elio, and González, Carlos A

Published
2012
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35. Educational level and risk of colorectal cancer in EPIC with specific reference to tumor location

Author

Leufkens, Anke M., Van Duijnhoven, Fränzel J.B., Boshuizen, Hendriek C., Siersema, Peter D., Kunst, Anton E., Mouw, Traci, Tjnneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Polidoro, Silvia, Palli, Domenico, Kaaks, Rudolf, Teucher, Birgit, Pischon, Tobias, Trichopoulou, Antonia, Orfanos, Philippos, Goufa, Ioulia, Peeters, Petra H.M., Skeie, Guri, Braaten, Tonje, Rodríguez, Laudina, Lujan-Barroso, Leila, Sánchez-Pérez, Maria-José, Navarro, Carmen, Barricarte, Aurelio, Zackrisson, Sophia, Almquist, Martin, Hallmans, Goran, Palmqvist, Richard, Tsilidis, Konstantinos K., Khaw, Kay-Tee, Wareham, Nick, Gallo, Valentina, Jenab, Mazda, Riboli, Elio, and Bueno-de-Mesquita, Bas H.

Published
2012
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36. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

Author

Jayasekara, Harindra, primary, MacInnis, Robert J., additional, Lujan‐Barroso, Leila, additional, Mayen‐Chacon, Ana‐Lucia, additional, Cross, Amanda J., additional, Wallner, Bengt, additional, Palli, Domenico, additional, Ricceri, Fulvio, additional, Pala, Valeria, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Tsilidis, Kostas, additional, Sánchez, Maria‐Jose, additional, Amiano, Pilar, additional, Ardanaz, Eva, additional, Chirlaque López, María Dolores, additional, Merino, Susana, additional, Rothwell, Joseph A., additional, Boutron‐Ruault, Marie‐Christine, additional, Severi, Gianluca, additional, Sternby, Hanna, additional, Sonestedt, Emily, additional, Bueno‐de‐Mesquita, Bas, additional, Boeing, Heiner, additional, Travis, Ruth, additional, Sandanger, Torkjel M., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Tjønneland, Anne, additional, Yang, Yi, additional, Hodge, Allison M., additional, Mitchell, Hazel, additional, Haydon, Andrew, additional, Room, Robin, additional, Hopper, John L., additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, Riboli, Elio, additional, Giles, Graham G., additional, Milne, Roger L., additional, Agudo, Antonio, additional, English, Dallas R., additional, and Ferrari, Pietro, additional

Published
2021
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37. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort

Author

Lujan-Barroso, Leila, primary, Botteri, Edoardo, additional, Caini, Saverio, additional, Ljungberg, Börje, additional, Roswall, Nina, additional, Tjønneland, Anne, additional, Bueno-de-Mesquita, Bas, additional, Gram, Inger T., additional, Tumino, Rosario, additional, Kiemeney, Lambertus A., additional, Liedberg, Fredrik, additional, Stocks, Tanja, additional, Gunter, Marc J., additional, Murphy, Neil, additional, Cervenka, Iris, additional, Fournier, Agnès, additional, Kvaskoff, Marina, additional, Häggström, Christel, additional, Overvad, Kim, additional, Lund, Eiliv, additional, Waaseth, Marit, additional, Fortner, Renée Turzanski, additional, Kühn, Tilman, additional, Menéndez, Virginia, additional, Sánchez, Maria-Jose, additional, Santiuste, Carmen, additional, Perez-Cornago, Aurora, additional, Zamora-Ros, Raul, additional, Cross, Amanda J., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Sciannameo, Veronica, additional, Mattiello, Amalia, additional, Panico, Salvatore, additional, van Gils, Carla H., additional, Onland-Moret, N. Charlotte, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Khaw, Kay-Tee, additional, Boeing, Heiner, additional, Weiderpass, Elisabete, additional, and Duell, Eric J., additional

Published
2020
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38. Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

Author

Duell, Eric J., Travier, Noémie, Lujan-Barroso, Leila, Boutron-Ruault, M. C., Clavel-Chapelon, F., Palli, Domenico, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Rodriguez, Laudina, Sanchez-Cantalejo, Emilio, Navarro, Carmen, Barricarte, Aurelio, Dorronsoro, Miren, Khaw, Kay-Tee, Wareham, Nicholas, Allen, Naomi E., Tsilidis, Konstantinos K., Bueno-de-Mesquita, H. Bas, Jeurnink, Suzanne M., Numans, M. E., Peeters, Petra H. M., Lagiou, Pagona, Valanou, Elisabeth, Trichopoulou, Antonia, Kaaks, Rudolf, Lukanova-McGregor, Annekatrin, Bergman, Manuela M., Boeing, Heiner, Manjer, Jonas, Lindkvist, Björn, Stenling, Roger, Hallmans, Göran, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Bakken, Kjersti, Lund, Eiliv, Jenab, Mazda, McCormack, Valerie, Rinaldi, Sabina, Michaud, Dominique, Mouw, Traci, Nesi, Gabriella, Carneiro, Fatima, Riboli, Elio, and González, Carlos A.

Published
2010
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39. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk : A Prospective Study in the EPIC Cohort

Author

Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjonneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, Duell, Eric J., Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjonneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, and Duell, Eric J.

Abstract

Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. Methods: Weused an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR= 5vs1 = 0.48; 0.25-0.90; Ptrend in parous women = 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR = 1.27; 1.03-1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non-muscleinvasive urothelial carcinoma risk was observed. Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.

Published
2020
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40. Exogenous hormone use and cutaneous melanoma risk in women : The European Prospective Investigation into Cancer and Nutrition

Author

Cervenka, Iris, Al Rahmoun, Marie, Mahamat-Saleh, Yahya, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Caini, Saverio, Palli, Domenico, Ghiasvand, Reza, Veierod, Marit B., Botteri, Edoardo, Tjonneland, Anne, Olsen, Anja, Fortner, Renee T., Kaaks, Rudolf, Schulze, Matthias B., Panico, Salvatore, Trichopoulou, Antonia, Dessinioti, Clio, Niforou, Katerina, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Sandanger, Torkjel M., Colorado-Yohar, Sandra, Sanchez, Maria J., Gil Majuelo, Leire, Lujan-Barroso, Leila, Ardanaz, Eva, Merino, Susana, Isaksson, Karolin, Butt, Salma, Ljuslinder, Ingrid, Jansson, Malin, Travis, Ruth C., Khaw, Kay-Tee, Weiderpass, Elisabete, Dossus, Laure, Rinaldi, Sabina, Kvaskoff, Marina, Cervenka, Iris, Al Rahmoun, Marie, Mahamat-Saleh, Yahya, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Caini, Saverio, Palli, Domenico, Ghiasvand, Reza, Veierod, Marit B., Botteri, Edoardo, Tjonneland, Anne, Olsen, Anja, Fortner, Renee T., Kaaks, Rudolf, Schulze, Matthias B., Panico, Salvatore, Trichopoulou, Antonia, Dessinioti, Clio, Niforou, Katerina, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Sandanger, Torkjel M., Colorado-Yohar, Sandra, Sanchez, Maria J., Gil Majuelo, Leire, Lujan-Barroso, Leila, Ardanaz, Eva, Merino, Susana, Isaksson, Karolin, Butt, Salma, Ljuslinder, Ingrid, Jansson, Malin, Travis, Ruth C., Khaw, Kay-Tee, Weiderpass, Elisabete, Dossus, Laure, Rinaldi, Sabina, and Kvaskoff, Marina

Abstract

Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from country‐specific self‐administered questionnaires. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Over 1992–2015, 1,696 melanoma cases were identified among 334,483 women, whereof 770 cases among 134,758 postmenopausal women. There was a positive, borderline‐significant association between OC use and melanoma risk (HR = 1.12, 95% CI = 1.00–1.26), with no detected heterogeneity across countries (phomogeneity = 0.42). This risk increased linearly with duration of use (ptrend = 0.01). Among postmenopausal women, ever use of MHT was associated with a nonsignificant increase in melanoma risk overall (HR = 1.14, 95% CI = 0.97–1.43), which was heterogeneous across countries (phomogeneity = 0.05). Our findings do not support a strong and direct association between exogenous hormone use and melanoma risk. In order to better understand these relations, further research should be performed using prospectively collected data including detailed information on types of hormone, and on sun exposure, which may act as an important confounder or effect modifier on these relations.

Published
2020
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41. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author

Obon-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Naudin, Sabine, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Rebours, Vinciane, Kuehn, Tilman, Katzke, Verena, Boeing, Heiner, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Lasheras, Cristina, Rodriguez-Barranco, Miguel, Amiano, Pilar, Santiuste, Carmen, Ardanaz, Eva, Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Trichopoulou, Antonia, Thriskos, Paschalis, Peppa, Eleni, Masala, Giovanna, Grioni, Sara, Tumino, Rosario, Panico, Salvatore, Bueno-de-Mesquita, Bas, Sciannameo, Veronica, Vermeulen, Roel, Sonestedt, Emily, Sund, Malin, Weiderpass, Elisabete, Skeie, Guri, Gonzalez, Carlos A., Riboli, Elio, Duell, Eric J., Obon-Santacana, Mireia, Lujan-Barroso, Leila, Freisling, Heinz, Naudin, Sabine, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Rebours, Vinciane, Kuehn, Tilman, Katzke, Verena, Boeing, Heiner, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Lasheras, Cristina, Rodriguez-Barranco, Miguel, Amiano, Pilar, Santiuste, Carmen, Ardanaz, Eva, Khaw, Kay-Thee, Wareham, Nicholas J., Schmidt, Julie A., Aune, Dagfinn, Trichopoulou, Antonia, Thriskos, Paschalis, Peppa, Eleni, Masala, Giovanna, Grioni, Sara, Tumino, Rosario, Panico, Salvatore, Bueno-de-Mesquita, Bas, Sciannameo, Veronica, Vermeulen, Roel, Sonestedt, Emily, Sund, Malin, Weiderpass, Elisabete, Skeie, Guri, Gonzalez, Carlos A., Riboli, Elio, and Duell, Eric J.

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Published
2020
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42. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: AProspective Study in the EPIC Cohort

Author

Lujan-Barroso, Leila, Botteri, Edoardo, Caini, S., Ljungberg, B., Roswall, N., Tjonneland, A., Kiemeney, L.A., Weiderpass, E., Duell, Eric J., Lujan-Barroso, Leila, Botteri, Edoardo, Caini, S., Ljungberg, B., Roswall, N., Tjonneland, A., Kiemeney, L.A., Weiderpass, E., and Duell, Eric J.

Abstract

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Published
2020

43. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk:A Prospective Study in the EPIC Cohort

Author

Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjønneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Haeggstroem, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, Duell, Eric J., Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjønneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Haeggstroem, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, and Duell, Eric J.

Abstract

Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk.Methods: Weused an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models.Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR= 5vs1 = 0.48; 0.25-0.90; Ptrend in parous women = 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR = 1.27; 1.03-1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non-muscleinvasive urothelial carcinoma risk was observed.Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk.Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.

Published
2020

44. Exogenous hormone use and cutaneous melanoma risk in women:The European Prospective Investigation into Cancer and Nutrition

Author

Cervenka, Iris, Al Rahmoun, Marie, Mahamat-Saleh, Yahya, Fournier, Agnès, Boutron-Ruault, Marie Christine, Severi, Gianluca, Caini, Saverio, Palli, Domenico, Ghiasvand, Reza, Veierod, Marit B., Botteri, Edoardo, Tjønneland, Anne, Olsen, Anja, Fortner, Renée T., Kaaks, Rudolf, Schulze, Matthias B., Panico, Salvatore, Trichopoulou, Antonia, Dessinioti, Clio, Niforou, Katerina, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Sandanger, Torkjel M., Colorado-Yohar, Sandra, Sánchez, Maria J., Gil Majuelo, Leire, Lujan-Barroso, Leila, Ardanaz, Eva, Merino, Susana, Isaksson, Karolin, Butt, Salma, Ljuslinder, Ingrid, Jansson, Malin, Travis, Ruth C., Khaw, Kay Tee, Weiderpass, Elisabete, Dossus, Laure, Rinaldi, Sabina, Kvaskoff, Marina, Cervenka, Iris, Al Rahmoun, Marie, Mahamat-Saleh, Yahya, Fournier, Agnès, Boutron-Ruault, Marie Christine, Severi, Gianluca, Caini, Saverio, Palli, Domenico, Ghiasvand, Reza, Veierod, Marit B., Botteri, Edoardo, Tjønneland, Anne, Olsen, Anja, Fortner, Renée T., Kaaks, Rudolf, Schulze, Matthias B., Panico, Salvatore, Trichopoulou, Antonia, Dessinioti, Clio, Niforou, Katerina, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Sandanger, Torkjel M., Colorado-Yohar, Sandra, Sánchez, Maria J., Gil Majuelo, Leire, Lujan-Barroso, Leila, Ardanaz, Eva, Merino, Susana, Isaksson, Karolin, Butt, Salma, Ljuslinder, Ingrid, Jansson, Malin, Travis, Ruth C., Khaw, Kay Tee, Weiderpass, Elisabete, Dossus, Laure, Rinaldi, Sabina, and Kvaskoff, Marina

Abstract

Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from country-specific self-administered questionnaires. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Over 1992–2015, 1,696 melanoma cases were identified among 334,483 women, whereof 770 cases among 134,758 postmenopausal women. There was a positive, borderline-significant association between OC use and melanoma risk (HR = 1.12, 95% CI = 1.00–1.26), with no detected heterogeneity across countries (phomogeneity = 0.42). This risk increased linearly with duration of use (ptrend = 0.01). Among postmenopausal women, ever use of MHT was associated with a nonsignificant increase in melanoma risk overall (HR = 1.14, 95% CI = 0.97–1.43), which was heterogeneous across countries (phomogeneity = 0.05). Our findings do not support a strong and direct association between exogenous hormone use and melanoma risk. In order to better understand these relations, further research should be performed using prospectively collected data including detailed information on types of hormone, and on sun exposure, which may act as an important confounder or effect modifier on these relations.

Published
2020

45. Exogenous hormone use and cutaneous melanoma risk in women: The European Prospective Investigation into Cancer and Nutrition

Author

Cervenka, Iris, primary, Al Rahmoun, Marie, additional, Mahamat‐Saleh, Yahya, additional, Fournier, Agnès, additional, Boutron‐Ruault, Marie‐Christine, additional, Severi, Gianluca, additional, Caini, Saverio, additional, Palli, Domenico, additional, Ghiasvand, Reza, additional, Veierod, Marit B., additional, Botteri, Edoardo, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Fortner, Renée T., additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Panico, Salvatore, additional, Trichopoulou, Antonia, additional, Dessinioti, Clio, additional, Niforou, Katerina, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno‐de‐Mesquita, Bas, additional, Sandanger, Torkjel M., additional, Colorado‐Yohar, Sandra, additional, Sánchez, Maria J., additional, Gil Majuelo, Leire, additional, Lujan‐Barroso, Leila, additional, Ardanaz, Eva, additional, Merino, Susana, additional, Isaksson, Karolin, additional, Butt, Salma, additional, Ljuslinder, Ingrid, additional, Jansson, Malin, additional, Travis, Ruth C., additional, Khaw, Kay‐Tee, additional, Weiderpass, Elisabete, additional, Dossus, Laure, additional, Rinaldi, Sabina, additional, and Kvaskoff, Marina, additional

Published
2019
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46. Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Yang, Jiaxi, additional, Johnson, Theron, additional, Chang-Claude, Jenny, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Fournier, Agnès, additional, Mancini, Francesca Romana, additional, Kvaskoff, Marina, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Valanou, Elissavet, additional, Agnoli, Claudia, additional, Sacerdote, Carlotta, additional, Masala, Giovanna, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Van Gils, Carla H., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Weiderpass, Elisabete, additional, Lujan-Barroso, Leila, additional, Petrova, Dafina, additional, Santiuste, Carmen, additional, Quirós, J. Ramón, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Travis, Ruth C., additional, Gunter, Marc, additional, Dossus, Laure, additional, Christakoudi, Sofia, additional, Kaaks, Rudolf, additional, and Fortner, Renée Turzanski, additional

Published
2019
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47. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status

Author

Fedirko, Veronika, primary, Jenab, Mazda, additional, Méplan, Catherine, additional, Jones, Jeb S., additional, Zhu, Wanzhe, additional, Schomburg, Lutz, additional, Siddiq, Afshan, additional, Hybsier, Sandra, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Omichessan, Hanane, additional, Perduca, Vittorio, additional, Boutron-Ruault, Marie-Christine, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Aleksandrova, Krasimira, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Kotanidou, Anastasia, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Naccarati, Alessio, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel C.H., additional, Weiderpass, Elisabete, additional, Skeie, Guri, additional, Nøst, Therese Haugdahl, additional, Lujan-Barroso, Leila, additional, Quirós, J. Ramón, additional, Huerta, José María, additional, Rodríguez-Barranco, Miguel, additional, Barricarte, Aurelio, additional, Gylling, Björn, additional, Harlid, Sophia, additional, Bradbury, Kathryn E., additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Gunter, Marc, additional, Murphy, Neil, additional, Freisling, Heinz, additional, Tsilidis, Kostas, additional, Aune, Dagfinn, additional, Riboli, Elio, additional, Hesketh, John E., additional, and Hughes, David J., additional

Published
2019
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48. Predicting Circulating CA125 Levels among Healthy Premenopausal Women

Author

Sasamoto, Naoko, primary, Babic, Ana, additional, Rosner, Bernard A., additional, Fortner, Renée T., additional, Vitonis, Allison F., additional, Yamamoto, Hidemi, additional, Fichorova, Raina N., additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Overvad, Kim, additional, Kvaskoff, Marina, additional, Fournier, Agnès, additional, Romana Mancini, Francesca, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Peppa, Eleni, additional, Karakatsani, Anna, additional, Palli, Domenico, additional, Pala, Valeria, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Grasso, Chiara C., additional, Onland-Moret, N. Charlotte, additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Lujan-Barroso, Leila, additional, Rodríguez-Barranco, Miguel, additional, Colorado-Yohar, Sandra, additional, Barricarte, Aurelio, additional, Dorronsoro, Miren, additional, Idahl, Annika, additional, Lundin, Eva, additional, Sartor, Hanna, additional, Khaw, Kay-Tee, additional, Key, Timothy J., additional, Muller, David, additional, Riboli, Elio, additional, Gunter, Marc J., additional, Dossus, Laure, additional, Kaaks, Rudolf, additional, Cramer, Daniel W., additional, Tworoger, Shelley S., additional, and Terry, Kathryn L., additional

Published
2019
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49. Predicting Circulating CA125 Levels among Healthy Premenopausal Women

Author

Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A., Fortner, Renee T., Vitonis, Allison F., Yamamoto, Hidemi, Fichorova, Raina N., Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Kvaskoff, Marina, Fournier, Agnes, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Pala, Valeria, Mattiello, Amalia, Tumino, Rosario, Grasso, Chiara C., Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Ramon Quiros, J., Lujan-Barroso, Leila, Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Barricarte, Aurelio, Dorronsoro, Miren, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J., Muller, David, Riboli, Elio, Gunter, Marc J., Dossus, Laure, Kaaks, Rudolf, Cramer, Daniel W., Tworoger, Shelley S., Terry, Kathryn L., Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A., Fortner, Renee T., Vitonis, Allison F., Yamamoto, Hidemi, Fichorova, Raina N., Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Kvaskoff, Marina, Fournier, Agnes, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Pala, Valeria, Mattiello, Amalia, Tumino, Rosario, Grasso, Chiara C., Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Ramon Quiros, J., Lujan-Barroso, Leila, Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Barricarte, Aurelio, Dorronsoro, Miren, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J., Muller, David, Riboli, Elio, Gunter, Marc J., Dossus, Laure, Kaaks, Rudolf, Cramer, Daniel W., Tworoger, Shelley S., and Terry, Kathryn L.

Abstract

Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (>= 35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC). Results: The final linear CA125 prediction model included age, race, tubal ligation, endometriosis, menstrual phase at blood draw, and fibroids, which explained 7% of the total variance of CA125. The correlation between observed and predicted CA125 levels based on the abridged model (including age, race, and menstrual phase at blood draw) had similar correlation coefficients in NEC (r = 0.22) and in EPIC (r = 0.22). The dichotomous CA125 prediction model included age, tubal ligation, endometriosis, prior personal cancer diagnosis, family history of ovarian cancer, number of miscarriages, menstrual phase at blood draw, and smoking status with AUC of 0.83. The abridged dichotomous model (including age, number of miscarriages, menstrual phase at blood draw, and smoking status) showed similar AUCs in NEC (0.73) and in EPIC (0.78). Conclusions: We identified a combination of factors associated with CA125 levels in premenopausal women. Impact: Our model could be valuable in identifying healthy women likely to have elevated CA125 and consequently improve its specificity for ovarian cancer screening.

Published
2019
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50. Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status

Author

Fedirko, Veronika, Jenab, Mazda, Meplan, Catherine, Jones, Jeb S., Zhu, Wanzhe, Schomburg, Lutz, Siddiq, Afshan, Hybsier, Sandra, Overvad, Kim, Tjonneland, Anne, Omichessan, Hanane, Perduca, Vittorio, Boutron-Ruault, Marie-Christine, Kuehn, Tilman, Katzke, Verena, Aleksandrova, Krasimira, Trichopoulou, Antonia, Karakatsani, Anna, Kotanidou, Anastasia, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Agnoli, Claudia, Naccarati, Alessio, Bueno-de-Mesquita, Bas, Vermeulen, Roel C. H., Weiderpass, Elisabete, Skeie, Guri, Nost, Therese Haugdahl, Lujan-Barroso, Leila, Ramon Quiros, J., Maria Huerta, Jose, Rodriguez-Barranco, Miguel, Barricarte, Aurelio, Gylling, Björn, Harlid, Sophia, Bradbury, Kathryn E., Wareham, Nick, Khaw, Kay-Tee, Gunter, Marc, Murphy, Neil, Freisling, Heinz, Tsilidis, Kostas, Aune, Dagfinn, Riboli, Elio, Hesketh, John E., Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Meplan, Catherine, Jones, Jeb S., Zhu, Wanzhe, Schomburg, Lutz, Siddiq, Afshan, Hybsier, Sandra, Overvad, Kim, Tjonneland, Anne, Omichessan, Hanane, Perduca, Vittorio, Boutron-Ruault, Marie-Christine, Kuehn, Tilman, Katzke, Verena, Aleksandrova, Krasimira, Trichopoulou, Antonia, Karakatsani, Anna, Kotanidou, Anastasia, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Agnoli, Claudia, Naccarati, Alessio, Bueno-de-Mesquita, Bas, Vermeulen, Roel C. H., Weiderpass, Elisabete, Skeie, Guri, Nost, Therese Haugdahl, Lujan-Barroso, Leila, Ramon Quiros, J., Maria Huerta, Jose, Rodriguez-Barranco, Miguel, Barricarte, Aurelio, Gylling, Björn, Harlid, Sophia, Bradbury, Kathryn E., Wareham, Nick, Khaw, Kay-Tee, Gunter, Marc, Murphy, Neil, Freisling, Heinz, Tsilidis, Kostas, Aune, Dagfinn, Riboli, Elio, Hesketh, John E., and Hughes, David J.

Abstract

Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. Illumina Goldengateassays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only TXNRD1 rs11111979 retained borderline statistical significance after adjustment for correlated tests (PACT = 0.10; PACT significance threshold was P < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (FRZB, SMAD3, SMAD7) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.

Published
2019
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