117 results on '"Maddox, Thomas M."'
Search Results
2. The Cardiovascular Workforce Crisis: Navigating the Present, Planning for the Future.
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Maddox, Thomas M., Fry, Edward T.A., and Wilson, B. Hadley
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LABOR supply , *CRISES - Published
- 2024
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3. Innovation in Cardiovascular Care Delivery.
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Fry, Edward T.A., Maddox, Thomas M., and Bhatt, Ami B.
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- 2023
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4. ACC Health Policy Statement on Cardiovascular Disease Considerations for COVID-19 Vaccine Prioritization: A Report of the American College of Cardiology Solution Set Oversight Committee.
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Driggin, Elissa, Maddox, Thomas M., Ferdinand, Keith C., Kirkpatrick, James N., Ky, Bonnie, Morris, Alanna A., Mullen, J. Brendan, Parikh, Sahil A., Philbin, Daniel M., Vaduganathan, Muthiah, Philbin, Daniel M Jr, Gluckman, Ty J, Gulati, Chair Martha, Aggarwal, Niti R, Kumbhani, Dharam J, Bhave, Nicole M, Krittanawong, Chayakrit, Dehmer, Gregory J, Sala-Mercado, Javier A, and Gilbert, Olivia N
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COVID-19 vaccines , *CARDIOVASCULAR diseases , *LEGISLATIVE oversight , *HEALTH policy , *CARDIOLOGY - Abstract
[Display omitted] [ABSTRACT FROM AUTHOR]
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- 2021
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5. 2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee.
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Maddox, Thomas M., Januzzi, James L., Allen, Larry A., Breathett, Khadijah, Butler, Javed, Davis, Leslie L., Fonarow, Gregg C., Ibrahim, Nasrien E., Lindenfeld, JoAnn, Masoudi, Frederick A., Motiwala, Shweta R., Oliveros, Estefania, Patterson, J. Herbert, Walsh, Mary Norine, Wasserman, Alan, Yancy, Clyde W., Youmans, Quentin R., Writing Committee, and Januzzi, James L Jr
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HEART failure , *HYPERKALEMIA , *LEGISLATIVE oversight , *ARRHYTHMOGENIC right ventricular dysplasia , *COVID-19 , *HEART failure treatment , *CARDIOLOGY , *STROKE volume (Cardiac output) , *POLICY sciences , *DISEASE management - Published
- 2021
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6. Trends in U.S. Ambulatory Cardiovascular Care 2013 to 2017: JACC Review Topic of the Week.
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Maddox, Thomas M, Song, Yang, Allen, Joseph, Chan, Paul S, Khan, Adeela, Lee, Jane J, Mitchell, Joshua, Oetgen, William J, Ponirakis, Angelo, Segawa, Claire, Spertus, John A, Thorpe, Fran, Virani, Salim S, and Masoudi, Frederick A
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The National Cardiovascular Data Registry PINNACLE (Practice Innovation and Clinical Excellence) Registry is the largest outpatient cardiovascular practice registry in the world. It tracks real-world management and quality of 4 common cardiovascular conditions: heart failure, coronary artery disease, atrial fibrillation, and hypertension. In 2013, the PINNACLE Registry contained information on 2,898,505 patients, cared for by 4,859 providers in 431 practices. By 2017, the registry contained information on 6,040,996 patients, cared for by 8,853 providers in 724 practices. During this time period, care processes for PINNACLE patients generally improved. Among patients with heart failure, combined beta-blocker and renin-angiotensin antagonist medication rates increased from 60.7% to 72.8%. Among patients with coronary artery disease, statin medication rates increased from 66% to 80.1%. Among patients with atrial fibrillation, oral anticoagulation rates increased from 52.7% to 65.2%. In contrast, blood pressure control rates among patients with hypertension were largely stable. PINNACLE data also fueled a variety of quality measurement programs and 51 peer-reviewed publications. [ABSTRACT FROM AUTHOR]
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- 2020
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7. The Learning Healthcare System and Cardiovascular Care: A Scientific Statement From the American Heart Association.
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Maddox, Thomas M., Albert, Nancy M., Borden, William B., Curtis, Lesley H., Ferguson Jr., T. Bruce, Kao, David P., Marcus, Gregory M., Peterson, Eric D., Redberg, Rita, Rumsfeld, John S., Shah, Nilay D., Tcheng, James E., Ferguson, T Bruce Jr, and American Heart Association Council on Quality of Care and Outcomes Research; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; and Stroke Council
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CARDIOVASCULAR disease treatment , *MEDICAL informatics , *MEDICAL records , *HOSPITAL records , *HEART failure - Abstract
The learning healthcare system uses health information technology and the health data infrastructure to apply scientific evidence at the point of clinical care while simultaneously collecting insights from that care to promote innovation in optimal healthcare delivery and to fuel new scientific discovery. To achieve these goals, the learning healthcare system requires systematic redesign of the current healthcare system, focusing on 4 major domains: science and informatics, patient-clinician partnerships, incentives, and development of a continuous learning culture. This scientific statement provides an overview of how these learning healthcare system domains can be realized in cardiovascular disease care. Current cardiovascular disease care innovations in informatics, data uses, patient engagement, continuous learning culture, and incentives are profiled. In addition, recommendations for next steps for the development of a learning healthcare system in cardiovascular care are presented. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Solution Sets to Generate Actionable Knowledge for Cardiovascular Care.
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Maddox, Thomas M., Gluckman, Ty J., Doherty, John, and Kovacs, Richard J.
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SCIENTIFIC knowledge - Published
- 2019
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9. Aspirin Instead of Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Risk for Stroke.
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Hsu, Jonathan C., Maddox, Thomas M., Kennedy, Kevin, Katz, David F., Marzec, Lucas N., Lubitz, Steven A., Gehi, Anil K., Turakhia, Mintu P., and Marcus, Gregory M.
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PHYSIOLOGICAL effects of aspirin , *ANTICOAGULANTS , *ATRIAL fibrillation , *CARDIOLOGY , *ASPIRIN , *STROKE prevention , *COMPARATIVE studies , *RESEARCH methodology , *MEDICAL cooperation , *MEDICAL prescriptions , *ORAL drug administration , *RESEARCH , *RISK assessment , *STROKE , *WARFARIN , *EVALUATION research , *DISEASE complications ,STROKE risk factors ,THERAPEUTIC use of fibrinolytic agents - Abstract
Background: Oral anticoagulation (OAC), rather than aspirin, is recommended in patients with atrial fibrillation (AF) at moderate to high risk of stroke.Objectives: This study sought to examine patient and practice-level factors associated with prescription of aspirin alone compared with OAC in AF patients at intermediate to high stroke risk in real-world cardiology practices.Methods: The authors identified 2 cohorts of outpatients with AF and intermediate to high thromboembolic risk (CHADS2 score ≥2 and CHA2DS2-VASc ≥2) enrolled in the American College of Cardiology PINNACLE (Practice Innovation and Clinical Excellence) registry between 2008 and 2012. Using hierarchical modified Poisson regression models adjusted for patient and practice characteristics, the authors examined the prevalence and predictors of aspirin alone versus OAC prescription in AF patients at risk for stroke.Results: Of 210,380 identified patients with CHADS2 score ≥2 on antithrombotic therapy, 80,371 (38.2%) were treated with aspirin alone, and 130,009 (61.8%) were treated with warfarin or non-vitamin K antagonist OACs. In the cohort of 294,642 patients with CHA2DS2-VASc ≥2, 118,398 (40.2%) were treated with aspirin alone, and 176,244 (59.8%) were treated with warfarin or non-vitamin K antagonist OACs. After multivariable adjustment, hypertension, dyslipidemia, coronary artery disease, prior myocardial infarction, unstable and stable angina, recent coronary artery bypass graft, and peripheral arterial disease were associated with prescription of aspirin only, whereas male sex, higher body mass index, prior stroke/transient ischemic attack, prior systemic embolism, and congestive heart failure were associated with more frequent prescription of OAC.Conclusions: In a large, real-world cardiac outpatient population of AF patients with a moderate to high risk of stroke, more than 1 in 3 were treated with aspirin alone without OAC. Specific patient characteristics predicted prescription of aspirin therapy over OAC. [ABSTRACT FROM AUTHOR]- Published
- 2016
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10. Provider Type and Quality of Outpatient Cardiovascular Disease Care: Insights From the NCDR PINNACLE Registry.
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Virani, Salim S., Maddox, Thomas M., Chan, Paul S., Tang, Fengming, Akeroyd, Julia M., Risch, Samantha A., Oetgen, William J., Deswal, Anita, Bozkurt, Biykem, Ballantyne, Christie M., and Petersen, Laura A.
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CARDIOVASCULAR disease diagnosis , *CARDIOVASCULAR disease treatment , *OUTPATIENT medical care , *CARDIOLOGY , *HEALTH care teams , *MEDICAL quality control , *NURSE practitioners , *PHYSICIANS , *PHYSICIANS' assistants , *RESEARCH funding , *ACQUISITION of data ,PATIENT Protection & Affordable Care Act - Abstract
Background: The current number of physicians will not be sufficient to accommodate 30 to 40 million Americans expected to secure health coverage with Affordable Care Act implementation. One proposed solution is to use advanced practice providers (APPs) (nurse practitioners and physician assistants).Objectives: This study sought to determine whether there were clinically meaningful differences in the quality of care delivered by APPs versus physicians in a national sample of cardiology practices.Methods: Within the American College of Cardiology's PINNACLE Registry, we compared quality of coronary artery disease (CAD), heart failure, and atrial fibrillation care delivered by physicians and APPs for outpatient visits between January 1, 2012, and December 31, 2012. We performed hierarchical regression adjusting for provider sex; panel size; duration of participation in registry; and patient's age, sex, insurance, number of outpatient visits, history of hypertension, diabetes, myocardial infarction, and percutaneous coronary intervention or coronary artery bypass grafting in the preceding 12 months.Results: We included 883 providers (716 physicians and 167 APPs) in 41 practices who cared for 459,669 patients. Mean number of patients seen by APPs (260.7) was lower compared with that seen by physicians (581.2). Compliance with most CAD, heart failure, and atrial fibrillation measures was comparable, except for a higher rate of smoking cessation screening and intervention (adjusted rate ratio: 1.14; 95% confidence interval: 1.03 to 1.26) and cardiac rehabilitation referral (rate ratio: 1.40; 95% confidence interval: 1.16 to 1.70) among CAD patients receiving care from APPs. Compliance with all eligible CAD measures was low for both (12.1% and 12.2% for APPs and physicians, respectively) with no significant difference. Results were consistent when comparing practices with both physicians and APPs (n = 41) and physician-only practices (n = 49).Conclusions: Apart from minor differences, a collaborative care delivery model, using both physicians and APPs, may deliver an overall comparable quality of outpatient cardiovascular care compared with a physician-only model. [ABSTRACT FROM AUTHOR]- Published
- 2015
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11. Impact of the 2014 Expert Panel Recommendations for Management of High Blood Pressure on Contemporary Cardiovascular Practice: Insights From the NCDR PINNACLE Registry.
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Borden, William B., Maddox, Thomas M., Tang, Fengming, Rumsfeld, John S., Oetgen, William J., Mullen, J. Brendan, Spinler, Sarah A., Peterson, Eric D., and Masoudi, Frederick A.
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HYPERTENSION , *THERAPEUTICS , *CARDIOVASCULAR diseases risk factors , *TRANSIENT ischemic attack , *MEDICAL registries , *BLOOD pressure , *MEDICAL practice - Abstract
Background Since 2003, the Seventh Report of the Joint National Committee (JNC-7) has been the predominant guideline for blood pressure management. A 2014 expert panel recommended increasing the blood pressure targets for patients age 60 years and older, as well as those with diabetes or chronic kidney disease. Objectives The purpose of this study was to examine the effect of the 2014 expert panel blood pressure management recommendations on patients managed in U.S. ambulatory cardiovascular practices. Methods Using the National Cardiovascular Data Registry PINNACLE Registry, we assessed the proportion of patients who met the 2003 and 2014 panel recommendations, highlighting the populations of patients for whom the blood pressure goals changed. Results Of 1,185,253 patients in the study cohort, 706,859 (59.6%) achieved the 2003 JNC-7 goals. Using the 2014 recommendations, 880,378 (74.3%) patients were at goal. Among the 173,519 (14.6%) for whom goal achievement changed, 40,323 (23.2%) had a prior stroke or transient ischemic attack, and 112,174 (64.6%) had coronary artery disease. In addition, the average Framingham risk score in this group was 8.5 ± 3.2%, and the 10-year ASCVD risk score was 28.0 ± 19.5%. Conclusions Among U.S. ambulatory cardiology patients with hypertension, nearly 1 in 7 who did not meet JNC-7 recommendations would now meet the 2014 treatment goals. If the new recommendations are implemented in clinical practice, blood pressure target achievement and cardiovascular events will need careful monitoring, because many patients for whom the target blood pressure is now more permissive are at high cardiovascular risk. [ABSTRACT FROM AUTHOR]
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- 2014
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12. Implications of the 2013 ACC/AHA Cholesterol Guidelines for Adults in Contemporary Cardiovascular Practice: Insights From the NCDR PINNACLE Registry.
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Maddox, Thomas M., Borden, William B., Tang, Fengming, Virani, Salim S., Oetgen, William J., Mullen, J. Brendan, Chan, Paul S., Casale, Paul N., Douglas, Pamela S., Masoudi, Fredrick A., Farmer, Steven A., and Rumsfeld, John S.
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CARDIOVASCULAR disease treatment , *CARDIOVASCULAR disease prevention , *LOW density lipoproteins , *MEDICAL registries , *STATINS (Cardiovascular agents) - Abstract
Background In a significant update, the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines recommend fixed-dose statin therapy for those at risk and do not recommend nonstatin therapies or treatment to target low-density lipoprotein cholesterol (LDL-C) levels, limiting the need for repeated LDL-C testing. Objectives The goal of this study was to examine the impact of the 2013 ACC/AHA cholesterol guidelines on current U.S. cardiovascular practice. Methods Using the NCDR PINNACLE (National Cardiovascular Data Registry Practice Innovation and Clinical Excellence) registry data from 2008 to 2012, we assessed current practice patterns as a function of the 2013 cholesterol guidelines. Lipid-lowering therapies and LDL-C testing patterns by patient risk group (atherosclerotic cardiovascular disease [ASCVD], diabetes, LDL-C ≥190 mg/dl, or an estimated 10-year ASCVD risk ≥7.5%) were described. Results Among a cohort of 1,174,545 patients, 1,129,205 (96.1%) were statin-eligible (91.2% ASCVD, 6.6% diabetes, 0.3% off-treatment LDL-C ≥190 mg/dl, 1.9% estimated 10-year ASCVD risk ≥7.5%). There were 377,311 patients (32.4%) not receiving statin therapy and 259,143 (22.6%) receiving nonstatin therapies. During the study period, 20.8% of patients had 2 or more LDL-C assessments, and 7.0% had more than 4. Conclusions In U.S. cardiovascular practices, 32.4% of statin-eligible patients, as defined by the 2013 ACC/AHA cholesterol guidelines, were not currently receiving statins. In addition, 22.6% were receiving nonstatin lipid-lowering therapies and 20.8% had repeated LDL-C testing. Achieving concordance with the new cholesterol guidelines in patients treated in U.S. cardiovascular practices would result in significant increases in statin use, as well as significant reductions in nonstatin therapies and laboratory testing. [ABSTRACT FROM AUTHOR]
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- 2014
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13. A National Clinical Quality Program for Veterans Affairs Catheterization Laboratories (from the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program)
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Maddox, Thomas M, Plomondon, Mary E, Petrich, Megan, Tsai, Thomas T, Gethoffer, Hans, Noonan, Gregory, Gillespie, Brian, Box, Tamara, Fihn, Stephen D, Jesse, Robert L, and Rumsfeld, John S
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- 2014
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14. Right- and Left-Sided Heart Catheterization as a Quality Marker for Catheterization Laboratories (from the National Veterans Affairs Clinical Assessment Reporting and Tracking Program)
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Yeo, Khung Keong, Maddox, Thomas M, Carey, Evan, Low, Reginald I, and Shunk, Kendrick A
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- 2014
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15. Right- and Left-Sided Heart Catheterization as a Quality Marker for Catheterization Laboratories (from the National Veterans Affairs Clinical Assessment Reporting and Tracking Program).
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Khung Keong Yeo, Maddox, Thomas M., Carey, Evan, Low, Reginald I., and Shunk, Kendrick A.
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CARDIAC catheterization , *CORONARY disease , *CARDIAC imaging , *CARDIOVASCULAR diseases risk factors , *PATIENTS - Abstract
The rate of concurrent right-heart catheterization (RHC) in patients undergoing left-heart catheterization (LHC) for coronary artery disease (CAD) indications or bilateral heart catheterization (BHC) is recommended as a measure of hospital quality, with higher rates suggesting over utilization. Our aim was to describe the prevalence of BHC and abnormal RHC findings in patients undergoing BHC with a primary indication for LHC. A retrospective analysis was performed for patients undergoing cardiac catheterization for CAD indications using the Department of Veterans Affairs Clinical Assessment Reporting and Tracking Program. Patients undergoing catheterization from October 2007 to September 2011 in 76 Veterans Affairs hospitals were included. Among 95,656 patients undergoing catheterization for CAD, 6,611 (6.9%) underwent BHC and 88,929 (93.0%) LHC. Among the patients undergoing BHC, 61.3% had at least 1 of the following abnormal RHC values: mean pulmonary artery (PA) pressure >25 mm Hg, pulmonary capillary wedge pressure (PCWP) >15 mm Hg, or pulmonary vascular resistance (PVR) >3 Woods units. A total of 37.5% of patients had mean PA pressures of 26 to 40 mm Hg and 11.1% had mean PA pressures >40 mm Hg. A total of 34.4% of patients had mean PCWP of 16 to 25 mm Hg and 13.6% had mean PAWP >25 mm Hg. A total of 16.5% of patients had PVR between 3 and 6 WU and 2.9% had PVR >6 WU. A total of 4.3% of patients met formal criteria for pulmonary arterial hypertension (defined as the combination of PA mean >25 mm Hg, PCWP £15 mm Hg, and PVR >3). In conclusion, these findings suggest that most BHC were performed for appropriate clinical reasons. Future studies should further explore BHC rate as an effective quality indicator. [ABSTRACT FROM AUTHOR]
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- 2014
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16. A National Clinical Quality Program for Veterans Affairs Catheterization Laboratories (from the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program).
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Maddox, Thomas M., Plomondon, Mary E., Petrich, Megan, Tsai, Thomas T., Gethoffer, Hans, Noonan, Gregory, Gillespie, Brian, Box, Tamara, Fihn, Stephen D., Jesse, Robert L., and Rumsfeld, John S.
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VETERANS' health , *CARDIAC catheterization , *CARDIAC surgery , *HEART disease diagnosis , *MEDICAL care - Abstract
A "learning health care system", as outlined in a recent Institute of Medicine report, harnesses real-time clinical data to continuously measure and improve clinical care. However, most current efforts to understand and improve the quality of care rely on retrospective chart abstractions complied long after the provision of clinical care. To align more closely with the goals of a learning health care system, we present the novel design and initial results of the Veterans Affairs (VA) Clinical Assessment, Reporting, and Tracking (CART) program--a national clinical quality program for VA cardiac catheterization laboratories that harnesses real-time clinical data to support clinical care and quality-monitoring efforts. Integrated within the VA electronic health record, the CART program uses a specialized software platform to collect real-time patient and procedural data for all VA patients undergoing coronary procedures in VA catheterization laboratories. The program began in 2005 and currently contains data on 434,967 catheterization laboratory procedures, including 272,097 coronary angiograms and 86,481 percutaneous coronary interventions, performed by 801 clinicians on 246,967 patients. We present the initial data from the CART program and describe 3 quality-monitoring programs that use its unique characteristics--procedural and complications feedback to individual labs, coronary device surveillance, and major adverse event peer review. The VA CART program is a novel approach to electronic health record design that supports clinical care, quality, and safety in VA catheterization laboratories. Its approach holds promise in achieving the goals of a learning health care system. [ABSTRACT FROM AUTHOR]
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- 2014
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17. Nonobstructive Coronary Artery Disease and Risk of Myocardial Infarction.
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Maddox, Thomas M., Stanislawski, Maggie A., Grunwald, Gary K., Bradley, Steven M., Ho, P. Michael, Tsai, Thomas T., Patel, Manesh R., Sandhu, Amneet, Valle, Javier, Magid, David J., Leon, Benjamin, Bhatt, Deepak L., Fihn, Stephan D., and Rumsfeld, John S.
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CORONARY disease , *ADVERSE health care events , *MYOCARDIAL infarction , *ANGIOGRAPHY ,DISEASES in veterans - Abstract
IMPORTANCE Little is known about cardiac adverse events among patients with nonobstructive coronary artery disease (CAD). OBJECTIVE To compare myocardial infarction (Ml) and mortality rates between patients with nonobstructive CAD, obstructive CAD, and no apparent CAD in a national cohort. DESIGN. SETTING, AND PARTICIPANTS Retrospective cohort study of all US veterans undergoing elective coronary angiography for CAD between October 2007 and September 2012 in the Veterans Affairs health care system. Patients with prior CAD events were excluded. EXPOSURES Angiographic CAD extent, defined by degree (no apparent CAD: no stenosis >20%; nonobstructive CAD: ≥1 stenosis ≥ 20% but no stenosis ≥ 70%; obstructive CAD: any stenosis ≥ 70% or left main [LM] stenosis ≥ 50%) and distribution (1,2, or 3 vessel). MAIN OUTCOMES AND MEASURES The primary outcome was 1-year hospitalization for nonfatal Ml after the index angiography. Secondary outcomes included 1-year all-cause mortality and combined 1-year Ml and mortality. RESULTS Among 37 674 patients, 8384 patients (22.3%) had nonobstructive CAD and 20 899 patients (55.4%) had obstructive CAD. Within 1 year, 845 patients died and 385 were rehospitalized for Ml. Among patients with no apparent CAD, the 1-year Ml rate was 0.11% (n = 8,95% Cl, 0.10%-0.20%) and increased progressively by 1-vessel nonobstructive CAD, 0.24% (n = 10, 95% Cl, 0.10%-0.40%); 2-vessel nonobstructive CAD, 0.56% (n = 13, 95% Cl, 0.30%-1.00%); 3-vessel nonobstructive CAD, 0.59% (n = 6,95% Cl, 0.30%-1.30%); 1-vessel obstructive CAD, 1.18% (n = 101, 95% Cl, 1.00%-1.40%); 2-vessel obstructive CAD, 2.18% (n = 110, 95% Cl, 1.80%-2.60%); and 3-vessel or LM obstructive CAD, 2.47% (n = 137, 95% Cl, 2.10%-2.90%). After adjustment, 1-year Ml rates increased with increasing CAD extent. Relative to patients with no apparent CAD, patients with 1-vessel nonobstructive CAD had a hazard ratio (HR) for 1-year Ml of 2.0 (95% Cl, 0.8-5.1); 2-vessel nonobstructive HR, 4.6 (95% Cl, 2.0-10.5); 3-vessel nonobstructive HR, 4.5 (95% Cl, 1.6-12.5); 1-vessel obstructive HR, 9.0 (95% Cl, 4.2-19.0); 2-vessel obstructive HR, 16.5 (95% Cl, 8.1-33.7); and 3-vessel or LM obstructive HR, 19.5 (95% Cl, 9.9-38.2). One-year mortality rates were associated with increasing CAD extent, ranging from 1.38% among patients without apparent CAD to 4.30% with 3-vessel or LM obstructive CAD. After risk adjustment, there was no significant association between 1- or 2-vessel nonobstructive CAD and mortality, but there were significant associations with mortality for 3-vessel nonobstructive CAD (HR, 1.6; 95% Cl, 1.1-2.5), 1-vessel obstructive CAD (HR, 1.9; 95% Cl, 1.4-2.6), 2-vessel obstructive CAD (HR, 2.8; 95% Cl, 2.1-3.7), and 3-vessel or LM obstructive CAD (HR, 3.4; 95% Cl, 2.6-4.4). Similar associations were noted with the combined outcome. CONCLUSIONS AND RELEVANCE In this cohort of patients undergoing elective coronary angiography, nonobstructive CAD, compared with no apparent CAD, was associated with a significantly greater 1-year risk o f Ml and all-cause mortality. These findings suggest clinical importance of nonobstructive CAD and warrant further investigation of interventions to improve outcomes among these patients. [ABSTRACT FROM AUTHOR]
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- 2014
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18. Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic Surgery: Insights From the Veterans Affairs (VA) Clinical Assessment, Reporting, and Tracking (CART) Program.
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Maddox, Thomas M, Stanislawski, Maggie A, O'Donnell, Colin, Plomondon, Mary E, Bradley, Steven M, Ho, P Michael, Tsai, Thomas T, Shroff, Adhir R, Speiser, Bernadette, Jesse, Robert J, and Rumsfeld, John S
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BACKGROUND: The safety of percutaneous coronary intervention (PCI) at medical facilities without on-site cardiothoracic (CT) surgery has been established in clinical trials. However, the comparative effectiveness of this strategy in real-world practice, including impact on patient access and outcomes, is uncertain. The Veterans Affairs (VA) health care system has used this strategy, with strict quality oversight, since 2005, and can provide insight into this question. METHODS AND RESULTS: Among 24 387 patients receiving PCI at VA facilities between October 2007 and September 2010, 6616 (27.1%) patients underwent PCI at facilities (n=18) without on-site CT surgery. Patient drive time (as a proxy for access), procedural complications, 1-year mortality, myocardial infarction, and rates of subsequent revascularization procedures were compared by facility. Results were stratified by procedural indication (ST-segment-elevation myocardial infarction versus non-ST-segment-elevation myocardial infarction/unstable angina versus elective) and PCI volume. With the inclusion of PCI facilities without on-site CT surgery, median drive time for patients treated at those facilities decreased by 90.8 minutes (P<0.001). Procedural need for emergent coronary artery bypass graft and mortality rates were low and similar between facilities. Adjusted 1-year mortality and myocardial infarction rates were similar between facilities (hazard ratio in PCI facilities without relative to those with on-site CT surgery, 1.02; 95% confidence interval, 0.87-1.2), and not modified by either PCI indication or PCI volume. Subsequent revascularization rates were higher at sites without on-site CT surgery facilities (hazard ratio, 1.21; 95% confidence interval, 1.03-1.42). CONCLUSIONS: This study suggests that providing PCI facilities without on-site CT surgery in an integrated health care system with quality oversight improves patient access without compromising procedural or 1-year outcomes. [ABSTRACT FROM AUTHOR]
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- 2014
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19. Patient Access and 1-Year Outcomes of Percutaneous Coronary Intervention Facilities With and Without On-Site Cardiothoracic Surgery.
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Maddox, Thomas M., Stanislawski, Maggie A., O'Donnell, Colin, Plomondon, Mary E., Bradley, Steven M., Ho, P. Michael, Tsai, Thomas T., Shroff, Adhir R., Speiser, Bernadette, Jesse, Robert J., and Rumsfeld, John S.
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ANGIOPLASTY , *HEART valve surgery , *THORACIC surgery , *CARDIAC catheterization , *CATHETER ablation , *SURGICAL stents - Abstract
Background--The safety of percutaneous coronary intervention (PCI) at medical facilities without on-site cardiothoracic (CT) surgery has been established in clinical trials. However, the comparative effectiveness of this strategy in real-world practice, including impact on patient access and outcomes, is uncertain. The Veterans Affairs (VA) health care system has used this strategy, with strict quality oversight, since 2005, and can provide insight into this question. Methods and Results--Among 24387 patients receiving PCI at VA facilities between October 2007 and September 2010, 6616 (27.1%) patients underwent PCI at facilities (n=18) without on-site CT surgery. Patient drive time (as a proxy for access), procedural complications, 1-year mortality, myocardial infarction, and rates of subsequent revascularization procedures were compared by facility. Results were stratified by procedural indication (ST-segment-elevation myocardial infarction versus non-ST-segment-elevation myocardial infarction/unstable angina versus elective) and PCI volume. With the inclusion of PCI facilities without on-site CT surgery, median drive time for patients treated at those facilities decreased by 90.8 minutes (P<0.001). Procedural need for emergent coronary artery bypass graft and mortality rates were low and similar between facilities. Adjusted 1-year mortality and myocardial infarction rates were similar between facilities (hazard ratio in PCI facilities without relative to those with on-site CT surgery, 1.02; 95% confidence interval, 0.87-1.2), and not modified by either PCI indication or PCI volume. Subsequent revascularization rates were higher at sites without on-site CT surgery facilities (hazard ratio, 1.21; 95% confidence interval, 1.03-1.42). Conclusions--This study suggests that providing PCI facilities without on-site CT surgery in an integrated health care system with quality oversight improves patient access without compromising procedural or 1-year outcomes. [ABSTRACT FROM AUTHOR]
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- 2014
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20. Health Services Research in Improving the Delivery of Care for Patients with Cardiovascular Diseases: Moving From Observation to Innovation to Action.
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Maddox, Thomas M. and Ho, P Michael
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MEDICAL care research , *CARDIOVASCULAR disease treatment , *HEALTH services administration , *RESEARCH methodology , *RESEARCH management , *RESEARCH implementation , *MEDICAL care standards , *MEDICAL care - Abstract
The author discusses the role of health services research (HSR) in cardiovascular care. He mentions that HSR insights into the improvements for cardiovascular care delivery can lead to gains in healthcare value. He also emphasizes the need for innovation in how HSR ideas are designed and executed and the means for HSR investigators to speed the research timeline, such as generation of presentations aimed at operational leadership.
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- 2017
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21. Variations in Coronary Artery Disease Secondary Prevention Prescriptions Among Outpatient Cardiology Practices: Insights From the NCDR (National Cardiovascular Data Registry).
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Maddox, Thomas M., Chan, Paul S., Spertus, John A., Tang, Fengming, Jones, Phil, Ho, P. Michael, Bradley, Steven M., Tsai, Thomas T., Bhatt, Deepak L., and Peterson, Pamela N.
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CORONARY heart disease prevention , *ADRENERGIC beta blockers , *ACE inhibitors , *ANGIOTENSIN-receptor blockers , *MYOCARDIAL infarction , *DRUG utilization , *OUTPATIENT medical care , *MEDICAL practice - Abstract
Objectives: This study assessed practice variations in secondary prevention medication prescriptions among coronary artery disease (CAD) patients treated in outpatient practices participating in the National Cardiovascular Data Registry (NCDR) Practice Innovation and Clinical Excellence (PINNACLE) registry. Background: Among patients with CAD, secondary prevention with a combination of beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and statins reduces cardiac mortality and myocardial infarction (MI). Accordingly, every CAD patient should receive the combination of these medications for which they are eligible. However, little is known about current prescription patterns of these medications and the variation in use among outpatient cardiology clinics. Methods: Using data from NCDR PINNACLE registry, a national outpatient cardiology practice registry, we assessed medication prescription patterns among eligible CAD patients, between July 2008 and December 2010. Overall rates of prescription and variation by practice were calculated, adjusting for patient characteristics. Results: Among 156,145 CAD patients in 58 practices, 103,830 (66.5%) patients were prescribed the optimal combination of medications for which they were eligible. The median rate of optimal combined prescription by practice was 73.5% and varied from 28.8% to 100%. After adjustment for patient factors, the practice median rate ratio for prescription was 1.25 (95% confidence interval: 1.20 to 1.32), indicating a 25% likelihood that 2 random practices would differ in treating identical CAD patients. Conclusions: Among a national registry of CAD patients treated in outpatient cardiology practices, over one-third of patients failed to receive their optimal combination of secondary prevention medications. Significant variation was observed across practices, even after adjusting for patient characteristics, suggesting that quality improvement efforts may be needed to support more uniform practice. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
22. Normal Coronary Rates for Elective Angiography in the Veterans Affairs Healthcare System: Insights From the VA CART Program (Veterans Affairs Clinical Assessment Reporting and Tracking).
- Author
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Bradley, Steven M., Maddox, Thomas M., Stanislawski, Maggie A., O’Donnell, Colin I., Grunwald, Gary K., Tsai, Thomas T., Ho, P. Michael, Peterson, Eric D., and Rumsfeld, John S.
- Subjects
- *
CORONARY angiography , *VETERANS' health , *HEALTH programs , *REPORTING of diseases , *HOSPITAL care , *PUBLIC health - Abstract
Objectives: This study sought to determine if an integrated healthcare system is selective and consistent in the use of angiography, as reflected by normal coronary rates. Background: Rates of normal coronary arteries with elective coronary angiography vary considerably among U.S. community hospitals. This variation may in part reflect incentives in fee-for-service care. Methods: Using national data from the Veterans Affairs (VA) Clinical Assessment Reporting and Tracking (CART) program representing all 76 VA cardiac catheterization laboratories, we evaluated all patients who underwent elective coronary angiography from October 2007 to September 2010. Normal coronary angiography was defined as <20% stenosis in all vessels. To assess hospital-level variation in normal coronary rates, we categorized hospitals by quartiles as defined by their proportion of normal coronaries. Results: Overall, 4,829 of 22,538 patients (21.4%) had normal coronary angiography. Hospital proportions of normal coronaries varied markedly (median hospital proportion 20.5%; interquartile range: 15.1% to 25.3%; range: 5.5% to 48.5%). Categorized as hospital quartiles, the median proportion of normal coronaries in the lowest quartile was 10.8%, as compared with a median proportion of 19.1% in the second lowest quartile, 23.1% in the second highest quartile, and 30.3% in the highest quartile. Hospitals with lower rates of normal coronaries had higher rates of obstructive coronary disease (59.2% vs. 51.3% vs. 52.6% vs. 44.3%; p < 0.001) and subsequent revascularization (38.1% vs. 33.9% vs. 31.5% vs. 29.3%; p < 0.001). Conclusions: Approximately 1 in 5 patients undergoing elective coronary angiography in the VA had normal coronaries. This rate is lower than prior published studies in other systems. However, the observed hospital-level variation in normal coronary rates suggests opportunities to improve patient selection for diagnostic coronary angiography. [Copyright &y& Elsevier]
- Published
- 2014
- Full Text
- View/download PDF
23. Coronary Stents and Subsequent Surgery: Reported Provider Attitudes and Practice Patterns.
- Author
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GRAHAM, LAURA A., MADDOX, THOMAS M., ITANI, KAMAL M. F., and HAWN, MARY T.
- Subjects
- *
SURGICAL stents , *CARDIAC surgery , *ASPIRIN , *HEMORRHAGE , *OPERATIVE surgery - Abstract
Management of antiplatelet therapy in patients with cardiac stents who need subsequent surgery is complex. Current guidelines recommend delaying elective surgery or, if surgery is emergent, proceeding without aspirin cessation. This study assessed provider knowledge, attitudes, and practices for patients with cardiac stents needing subsequent surgery. A national survey was administered to Veterans Administration surgeons, anesthesiologists, and cardiologists. Questions examined guideline awareness and agreement, perceptions of bleeding risk and stent thrombosis, practice patterns for antiplatelet therapy management, and experience with perioperative stent thrombosis. Chi-square tests and generalized estimating equations were used to examine differences in reported practices. Among 295 respondents, guideline awareness (92%) and agreement (93%) were high but higher among cardiologists and anesthesiologists than surgeons. Guideline agreement and personal experience with stent thrombosis were also associated with reported practice patterns. In adjusted models for early surgeries, cardiologists and anesthesiologists were more likely to report continuation of dual therapy as compared with surgeons regardless of stent type (drug-eluting P = 0.03; bare metal P < 0.01). Despite successful guideline adoption, significant variations in practice patterns by provider type were found. Understanding reasons behind the variation and outcomes of various antiplatelet management strategies are important steps in optimizing care of patients with coronary stents undergoing noncardiac surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
24. Practice-Level Variation in Warfarin Use Among Outpatients With Atrial Fibrillation (from the NCDR PINNACLE Program)
- Author
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Chan, Paul S., Maddox, Thomas M., Tang, Fengming, Spinler, Sarah, and Spertus, John A.
- Subjects
- *
WARFARIN , *ATRIAL fibrillation treatment , *OUTPATIENT medical care , *ANTICOAGULANTS , *CONGESTIVE heart failure treatment , *HYPERTENSION ,THROMBOEMBOLISM treatment - Abstract
Warfarin is a complex but highly effective treatment for decreasing thromboembolic risk in atrial fibrillation (AF). We examined contemporary warfarin treatment rates in AF before the expected introduction of newer anticoagulants and extent of practice-level variation in warfarin use. Within the National Cardiovascular Data Registry Practice Innovation and Clinical Excellence program from July 2008 through December 2009, we identified 9,113 outpatients with AF from 20 sites who were at moderate to high risk for stroke (congestive heart failure, hypertension, age, diabetes, stroke score >1) and would be optimally treated with warfarin. Using hierarchical models, the extent of site-level variation was quantified with the median rate ratio, which can be interpreted as the likelihood that 2 random practices would differ in treating “identical” patients with warfarin. Overall rate of warfarin treatment was only 55.1% (5,018 of 9,913). Untreated patients and treated patients had mean congestive heart failure, hypertension, age, diabetes, stroke scores of 2.5 (p = 0.38) and similar rates of heart failure, hypertension, diabetes mellitus, and previous stroke, suggesting an almost “random” pattern of treatment. At the practice level, however, there was substantial variation in treatment ranging from 25% to 80% (interquartile range for practices 50 to 65), with a median rate ratio of 1.31 (1.22 to 1.55, p <0.001). In conclusion, within the Practice Innovation and Clinical Excellence registry, we found that warfarin treatment in AF was suboptimal, with large variations in treatment observed across practices. Our findings suggest important opportunities for practice-level improvement in stroke prevention for outpatients with AF and define a benchmark treatment rate before the introduction of newer anticoagulant agents. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
25. Contraindicated Medication Use in Dialysis Patients Undergoing Percutaneous Coronary Intervention.
- Author
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Tsai, Thomas T., Maddox, Thomas M., Roe, Matthew T., Dai, David, Alexander, Karen P., Ho, P. Michael, Messenger, John C., Nallamothu, Brahmajee K., Peterson, Eric D., and Rumsfeld, John S.
- Subjects
- *
HEMODIALYSIS patients , *EPTIFIBATIDE , *FIBRINOLYTIC agents , *HEMORRHAGE risk factors , *CLINICAL indications , *DIALYSIS (Chemistry) - Abstract
The article focuses on a study which examined the administration of contraindicated drugs enoxaparin and eptifibatide among dialysis patients who are undergoing percutaneous coronary intervention (PCI). The study included 22,778 dialysis patients who underwent PCI between January 1, 2004 and August 31, 2008 in the U.S. Study population was randomized to either receive enoxaparin, eptifibatide or both. Study authors found that patients who received contraindicated antithrombotics had higher risks of in-hospital bleeding and mortality.
- Published
- 2009
- Full Text
- View/download PDF
26. Risk of Adverse Outcomes Associated With Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Acute Coronary Syndrome.
- Author
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Ho, P. Michael, Maddox, Thomas M., Li Wang, Fihn, Stephan D., Jesse, Robert L., Peterson, Eric D., and Rumsfeld, John S.
- Subjects
- *
COHORT analysis , *ANTICOAGULANTS , *CARDIOVASCULAR diseases , *MORTALITY , *PROTON pump inhibitors - Abstract
The article presents a retrospective cohort study which assessed the outcomes of patients taking clopidogrel with or without a proton pump inhibitor (PPI) after hospitalization for acute coronary syndrome (ACS). 8205 patients with ACS taking clopidogrel after discharge from 127 Veterans Affairs hospitals between October 1, 2003 and January 31, 2006 were included in the study. The main outcome was all-cause mortality or rehospitalization for ACS. Researchers found that concomitant use of clopidogrel and PPI was associated with an increased risk of adverse outcomes compared with clopidogrel without PPI.
- Published
- 2009
- Full Text
- View/download PDF
27. The Potential of Learning Health Care Systems: The SWEDEHEART Example.
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Maddox, Thomas M. and Jr.Ferguson, T. Bruce
- Subjects
- *
MEDICAL care , *TYPE 1 diabetes , *CORONARY artery bypass , *MEDICAL registries , *HEALTH programs , *HEALTH outcome assessment , *PATIENTS - Published
- 2015
- Full Text
- View/download PDF
28. Angina at 1 Year After Myocardial Infarction: Prevalence and Associated Findings.
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Maddox, Thomas M., Reid, Kimberly J., Spertus, John A., Mittleman, Murray, Krumholz, Harlan M., Parashar, Susmita, Ho, P. Michael, and Rumsfeld, John S.
- Subjects
- *
HEART diseases , *ANGINA pectoris , *CORONARY disease , *MYOCARDIAL infarction , *BLOOD circulation disorders , *PREVENTION , *PATIENTS ,MYOCARDIAL infarction diagnosis - Abstract
The article presents a study on the elimination of angina one year after myocardial infarction. It aims to describe the instances of angina one year after myocardial infarction. The study examines 2498 patients from nineteen hospitals in the U. S. The patients were given the Seattle Angina Questionnaire one year after their treatment for angina. The patients were also studied for clinical history and demographics. The study found that 19.9 percent or three hundred eighty-nine out of 1,957 patients experienced angina one year after myocardial infarction. It concludes that factors including depression and smoking are associated with angina.
- Published
- 2008
- Full Text
- View/download PDF
29. Clinical Document Criteria Key to Collaboration and Ensuring Value in the Document Process.
- Author
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Kovacs, Richard J. and Maddox, Thomas M.
- Subjects
- *
VENTRICULAR arrhythmia , *MEDICAL care standards - Published
- 2019
- Full Text
- View/download PDF
30. Preoperative Cardiovascular Evaluation for Noncardiac Surgery.
- Author
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Maddox, Thomas M.
- Subjects
- *
CORONARY disease , *CARDIAC surgery , *CORONARY artery bypass , *HEART diseases , *SURGERY - Abstract
Cardiovascular complications following noncardiac surgery constitute an enormous burden of perioperative morbidity and mortality. Annually, more than one million operations are complicated by adverse cardiovascular events, such as perioperative myocardial infarction or death from cardiac causes. In order to combat this problem, cardiac evaluation prior to noncardiac surgery should ask two questions about the patient: What is the risk of cardiac complications during and after surgery? How can that risk be reduced or eliminated? Risk assessment evaluates patients' co-morbidides and exercise tolerance, as well as the type of surgery to be performed, to determine the overall risk of perioperative cardiac complications. Previous or current cardiac disease, diabetes and renal insufficiency all confer higher risks for perioperative cardiac complications. Poor exercise tolerance and high-risk surgical procedures (e.g., vascular, prolonged thoracic or abdominal operations) also predict worse perioperative outcomes. Noninvasive stress testing is widely used to help predict risk of perioperative complications, but the poor predictive power of these tests hampers their usefulness. After estimating the risk of cardiac complications, one should take measures to reduce it. Beta blockade has shown clear benefits in risk reduction. At this time, there are no data suggesting benefits of percutaneous coronary intervention or coronary artery bypass grafting in reducing noncardiac surgical risk. In addition, angioplasty with stenting and its attendant need for anticoagulation can expose patients to increased risk of perioperative bleeding. Thus, the use of coronary revascularization prior to noncardiac surgery should be reserved for those patients with an independent cardiac need for the procedure, such as unstable angina or stable angina refractory to medical therapy. In summary, patients with low clinical risk factors and good functional status, undergoing a low or intermediate r... [ABSTRACT FROM AUTHOR]
- Published
- 2005
31. Disparities in cardiac care: Rising to the challenge of healthy people 2010
- Author
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Lillie-Blanton, Marsha, Maddox, Thomas M., Rushing, Osula, and Mensah, George A.
- Subjects
- *
CARDIAC nursing , *MEDICAL anthropology , *THROMBOLYTIC therapy , *DRUG therapy - Abstract
Eliminating health disparities is one of two overarching goals of Healthy People 2010. Although the causes of health disparities are complex, they appear to be related, in part, to disparities in the quality of medical care. Two recent reviews of peer-reviewed research investigated the evidence on racial/ethnic differences in medical care. An Institute of Medicine summary of the literature concluded that in most studies, racial and ethnic disparities in health care remained even after adjustment for potentially confounding factors. A review focused specifically on cardiac care, conducted jointly by the Kaiser Family Foundation and the American College of Cardiology Foundation, reached a similar conclusion after examining the most rigorous studies investigating racial/ethnic differences in angiography, angioplasty, coronary artery bypass graft (CABG) surgery, and thrombolytic therapy. For example, African Americans were statistically less likely than whites to undergo CABG surgery in 21 of the 23 most rigorous studies that calculated odds ratios to compare CABG use. Although there is a convincing body of evidence that race continues to matter in the health system, a nationally representative survey of physicians revealed that the majority of physicians do not view a patient''s race/ethnicity as a factor in obtaining care, but do believe insurance coverage matters. Increasing physicians'' awareness of the evidence for the role that race/ethnicity plays in health care is important because they are in a good position to directly and indirectly affect changes in clinical practice or patient behavior that could reduce disparities in care. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF
32. Outcomes of in-hospital cardiac arrest among hospitals with and without telemedicine critical care.
- Author
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Ofoma, Uchenna R., Drewry, Anne M., Maddox, Thomas M., Boyle, Walter, Deych, Elena, Kollef, Marin, Girotra, Saket, Joynt Maddox, Karen E, and American Heart Association's Get With The Guidelines®- Resuscitation Investigators
- Subjects
- *
CARDIAC arrest , *CRITICAL care medicine , *INTENSIVE care units , *HOSPITAL wards , *HOSPITALS , *SURVIVAL rate - Abstract
Background: Survival rates following in-hospital cardiac arrest (IHCA) are lower during nights and weekends (off-hours), as compared to daytime on weekdays (on-hours). Telemedicine Critical Care (TCC) may provide clinical support to improve IHCA outcomes, particularly during off-hours.Objective: To evaluate the association between hospital availability of TCC and IHCA survival.Methods: We identified 44,585 adults at 280 U.S. hospitals in the Get With The Guidelines® - Resuscitation registry who suffered IHCA in an Intensive Care Unit (ICU) or hospital ward between July 2017 and December 2019. We used 2-level hierarchical multivariable logistic regression to investigate whether TCC availability was associated with better survival, overall, and during on-hours (Monday-Friday 7:00 a.m.-10:59p.m.) vs. off-hours (Monday-Friday 11:00p.m.-6:59 a.m., and Saturday-Sunday, all day, and US national holidays).Results: 14,373 (32.2%) participants suffered IHCA at hospitals with TCC, and 27,032 (60.6%) occurred in an ICU. There was no difference between TCC and non-TCC hospitals in acute resuscitation survival rate or survival to discharge rates for either IHCA occurring in the ICU (acute survival odds ratio [OR] 1.02, 95% CI 0.92-1.15; survival to discharge OR 0.94 [0.83-1.07]) or outside of the ICU (acute survival OR 1.03 [0.91-1.17]; survival to discharge OR 0.99 [0.86-1.12]. Timing of cardiac arrest did not modify the association between TCC availability and acute resuscitation survival (P =.37 for interaction) or survival to discharge (P =.39 for interaction).Conclusions: Hospital availability of TCC was not associated with improved outcomes for in-hospital cardiac arrest. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
33. Questions for Artificial Intelligence in Health Care.
- Author
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Maddox, Thomas M., Rumsfeld, John S., and Payne, Philip R. O.
- Subjects
- *
ARTIFICIAL intelligence in medicine , *MEDICAL innovations , *INFORMATION resources management , *ELECTRONIC health records , *MEDICAL informatics , *ARTIFICIAL intelligence , *DECISION support systems , *MEDICAL care , *PATIENTS , *ACQUISITION of data - Abstract
This Viewpoint discusses questions that should be addressed to successfully integrate artificial intelligence into clinical care. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
34. Impaired Chronotropic Response to Exercise Stress Testing in Patients With Diabetes Predicts Future Cardiovascular Events.
- Author
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Ho, P. Michael, Maddox, Thomas M., Ross, Colleen, Rumsfeld, John S., and Magid, David J.
- Subjects
- *
PEOPLE with diabetes , *CARDIOVASCULAR diseases , *ADVERSE health care events , *MYOCARDIAL infarction , *MORTALITY - Abstract
OBJECTIVES-- To assess the association between impaired chronotropic response (CR) and adverse events among patients with diabetes referred for exercise treadmill testing (ETT). RESEARCH DESIGN AND METHODS -- Impaired CR was defined as achievement of <80% of a patient's heart rate reserve. We used multivariable Cox proportional hazards regression to assess the independent association between impaired CR and adverse outcomes adjusting for demographics, comorbidities, and treadmill variables including the Duke Treadmill score. RESULTS -- Of 1,341 patients with diabetes, 35.7% (n = 479) demonstrated impaired CR during ETT. Patients with impaired CR were at increased risk of all-cause mortality, myocardial infarction, or coronary revascularization procedures. In multivariable analyses, impaired CR remained significantly associated with adverse outcomes (hazard ratio 1.53 [95% CI 1.10-2.141). CONCLUSIONS -- Among patients with diabetes, impaired CR is common during ETT and is associated with adverse outcomes. Impaired CR can be used as another noninvasive tool to risk-stratify patients with diabetes following ETT. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
35. Abstract 15410: Patient and Practice Characteristics Associated With Switching From Warfarin to Direct Oral Anticoagulants in Patients With Atrial Fibrillation - An Analysis From the NCDR PINNACLE Registry.
- Author
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Sciria, Christopher T, Maddox, Thomas M, Marzec, Lucas, O'Hare, Ali, Liu, Yuyin, Song, Yang, Doros, Gheorghe, Zheng, Yue, Lee, Jane, Cannon, Christopher, and Desai, Nihar R
- Subjects
- *
ATRIAL fibrillation , *WARFARIN , *RANDOM effects model , *CORONARY disease , *MOUNTAINS - Abstract
Introduction: Previous studies have examined patterns of DOACs in AF, but have exclusively focused on patients newly initiating therapy, and neglect the large reservoir of patients who were chronically receiving warfarin. We sought to examine predictors and patterns of care for patients switched from warfarin to DOACs. Methods: The study cohort included all patients in the NCDR PINNACLE registry with at least one prescription for warfarin for AF between May 1, 2008 and May 1, 2015. Patients were followed longitudinally and stratified based on their anticoagulation between October 1, 2010 and May 1, 2016 as follows: 1) continued warfarin, 2) switched to a DOAC, or 3) discontinued anticoagulation. To identify significant predictors of switching, a three level multivariable hierarchical regression was conducted, with patient baseline characteristics, comorbidities and medication use included as fixed effects, and practices and providers within the same practice modeled as random effects. Results: Of the 383,008 patients included, 62,620 (16.3%) switched to a DOAC while 263,609 (68.8%) continued on warfarin. Patients switching from warfarin to a DOAC were younger, white, have private insurance, and history of prior stroke; while those who were not switched tended to have diabetes, coronary artery disease, and heart failure (p<0.001 for all, Figure). The mean (SD) CHADS2-VASC for those switched was 3.5±1.7 and for those not switched 3.7±1.6; the mean (SD) HAS-BLED for those switched was 2.2±1.0 and for those not switched 2.2±0.9. There was substantial variation in switching patterns with a median odds ratio at the practice level of 2.42 (95% CI, 2.20-2.68) and for providers within the same practice 1.47 (95% CI, 1.44-1.50). Conclusions: There is substantial variation in patterns of switching from warfarin to DOACs with significant disparities based on sociodemographic characteristics without differences based on bleeding risk. [ABSTRACT FROM AUTHOR]
- Published
- 2018
36. Post-hospitalization remote monitoring for patients with heart failure or chronic obstructive pulmonary disease in an accountable care organization.
- Author
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Harris, Samantha, Paynter, Kayla, Guinn, Megan, Fox, Julie, Moore, Nathan, Maddox, Thomas M., and Lyons, Patrick G.
- Subjects
- *
ACCOUNTABLE care organizations , *CHRONIC obstructive pulmonary disease , *HEART failure patients , *PATIENT monitoring , *PATIENT readmissions - Abstract
Background: Post-hospitalization remote patient monitoring (RPM) has potential to improve health outcomes for high-risk patients with chronic medical conditions. The purpose of this study is to determine the extent to which RPM for patients with congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) is associated with reductions in post-hospitalization mortality, hospital readmission, and ED visits within an Accountable Care Organization (ACO). Methods: Nonrandomized prospective study of patients in an ACO offered enrollment in RPM upon hospital discharge between February 2021 and December 2021. RPM comprised of vital sign monitoring equipment (blood pressure monitor, scale, pulse oximeter), tablet device with symptom tracking software and educational material, and nurse-provided oversight and triage. Expected enrollment was for at least 30-days of monitoring, and outcomes were followed for 6 months following enrollment. The co-primary outcomes were (a) the composite of death, hospital admission, or emergency care visit within 180 days of eligibility, and (b) time to occurrence of this composite. Secondary outcomes were each component individually, the composite of death or hospital admission, and outpatient office visits. Adjusted analyses involved doubly robust estimation to address confounding by indication. Results: Of 361 patients offered remote monitoring (251 with CHF and 110 with COPD), 140 elected to enroll (106 with CHF and 34 with COPD). The median duration of RPM-enrollment was 54 days (IQR 34–85). Neither the 6-month frequency of the co-primary composite outcome (59% vs 66%, FDR p-value = 0.47) nor the time to this composite (median 29 vs 38 days, FDR p-value = 0.60) differed between the groups, but 6-month mortality was lower in the RPM group (6.4% vs 17%, FDR p-value = 0.02). After adjustment for confounders, RPM enrollment was associated with nonsignificantly decreased odds for the composite outcome (adjusted OR [aOR] 0.68, 99% CI 0.25–1.34, FDR p-value 0.30) and lower 6-month mortality (aOR 0.41, 99% CI 0.00–0.86, FDR p-value 0.20). Conclusions: RPM enrollment may be associated with improved health outcomes, including 6-month mortality, for selected patient populations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. The Capacity of Evidence to Inform Practice: The Rapid Registry Response (RRR) Initiative.
- Author
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Maddox, Thomas M., Masoudi, Frederick A., Oetgen, William J., and Rumsfeld, John S.
- Subjects
- *
ACUTE coronary syndrome , *MEDICAL registries , *STATINS (Cardiovascular agents) , *EZETIMIBE , *RANDOMIZED controlled trials , *HEALTH outcome assessment , *HETEROGENEITY , *PATIENTS - Published
- 2015
- Full Text
- View/download PDF
38. Reply: Getting Guidelines Correct: Their Evidence-Based Recommendations for Use of Nonstatins Added to Statins and the Need for Follow-Up Lipid Testing.
- Author
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Maddox, Thomas M., Oetgen, William J., and Rumsfeld, John S.
- Subjects
- *
EVIDENCE-based medicine , *STATINS (Cardiovascular agents) , *LOW density lipoproteins , *FOLLOW-up studies (Medicine) , *RANDOMIZED controlled trials , *MEDICAL care costs , *THERAPEUTICS - Published
- 2015
- Full Text
- View/download PDF
39. IMPLICATIONS OF THE IMPROVE-IT TRIAL FOR CONTEMPORARY CARDIOVASCULAR PRACTICE: AN NCDR® RESEARCH TO PRACTICE (R2P) PROJECT.
- Author
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Maddox, Thomas M., Tang, Fengming, Downs, John, Masoudi, Frederick, Virani, Salim, Daugherty, Stacie, and Rumsfeld, John
- Subjects
- *
RESEARCH - Published
- 2017
- Full Text
- View/download PDF
40. IMPLICATIONS OF THE IMPROVE-IT TRIAL FOR CONTEMPORARY CARDIOVASCULAR PRACTICE: AN NCDR® RESEARCH TO PRACTICE (R2P) PROJECT.
- Author
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Maddox, Thomas M., Tang, Fengming, Downs, John, Masoudi, Frederick, Virani, Salim, Daugherty, Stacie, and Rumsfeld, John
- Subjects
- *
CARDIOVASCULAR diseases , *ACUTE coronary syndrome , *ADRENERGIC beta blockers , *EZETIMIBE , *CLINICAL trials - Published
- 2017
- Full Text
- View/download PDF
41. Reply: Anticoagulation Treatment for Stroke Prevention in Atrial Fibrillation Is Increasing, But Further Improvements Needed.
- Author
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Hsu, Jonathan C., Maddox, Thomas M., and Marcus, Gregory M.
- Subjects
- *
ATRIAL fibrillation , *STROKE prevention , *STROKE treatment , *ANTICOAGULANTS , *MEDICAL consultation , *STROKE , *THROMBOLYTIC therapy - Published
- 2016
- Full Text
- View/download PDF
42. PCI without surgical backup--evidence-based, but wise?
- Author
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Maddox, Thomas M. and Rumsfeld, John S.
- Subjects
- *
CARDIAC surgery , *OPERATIVE surgery , *MEDICAL quality control , *ACUTE coronary syndrome , *PREVENTION , *SAFETY ,PREVENTION of surgical complications - Abstract
The results of MASS COMM support the safety of performing percutaneous coronary intervention at centres without on-site cardiothoracic surgery services. To translate these findings into clinical practice, robust quality oversight programmes, with direct measurement of procedural outcomes and complications, are needed. The VA CART programme provides a model for such a strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
43. Cardiovascular risks of stopping antiplatelet therapy before non-cardiac surgery for patients with coronary stents.
- Author
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Maddox, Thomas M.
- Subjects
- *
CARDIOVASCULAR diseases risk factors , *SURGICAL stents , *OPERATIVE surgery , *PLATELET aggregation inhibitors - Abstract
The article provides an overview of the study conducted by Albaladejo and colleagues for identifying cardiovascular (CV) risks associated with the discontinuation of antiplatelet therapy before non-cardiac surgery in patients suffering from coronary stents. Interruption of antiplateley therapy, anaemia and severe renal insufficiency are shown to be some of the main factors associated with CV events. Recommendations for avoiding CV risks in these patients are also presented.
- Published
- 2012
- Full Text
- View/download PDF
44. Cell therapy for cardiac disease: where do we go from here?
- Author
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Adler, Eric D. and Maddox, Thomas M.
- Subjects
- *
BONE marrow cells , *CLINICAL trials , *CELLS , *CELLULAR therapy , *THERAPEUTICS - Abstract
The article reflects on the need for future clinical trials on the potential therapeutic value of bone marrow cells (BMCs) to focus on the inclusion of clinically relevant endpoints. It notes that previous studies have demonstrated that only relatively substantial changes in ejection fraction (EF) strongly predict improvements in symptoms or mortality. It cites the most important step in the future of cell therapy.
- Published
- 2007
- Full Text
- View/download PDF
45. Response to Comment on Shore et al. Association Between Hyperglycemia at Admission During Hospitalization for Acute Myocardial Infarction and Subsequent Diabetes: Insights From the Veterans Administration Cardiac Care Follow-up Clinical Study. Diabetes Care 2014;37:409-418.
- Author
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Shore, Supriya and Maddox, Thomas M
- Published
- 2014
- Full Text
- View/download PDF
46. Association Between Hyperglycemia at Admission During Hospitalization for Acute Myocardial Infarction and Subsequent Diabetes: Insights From the Veterans Administration Cardiac Care Follow-up Clinical Study. Diabetes Care 2014;37:409-418.
- Author
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Shore, Supriya and Maddox, Thomas M.
- Subjects
- *
HYPERGLYCEMIA , *MYOCARDIAL infarction , *DIABETES - Abstract
A response by the authors to a review of their article "Association Between Hyperglycemia at Admission During Hospitalization for Acute Myocardial Infarction and Subsequent Diabetes: Insights From the Veterans Administration Cardiac Care Follow-Up Clinical Study" which appeared in a 2014 issue of the periodical "Diabetes Care" is presented.
- Published
- 2014
- Full Text
- View/download PDF
47. Gap between clinical guidelines and practice: The case of aldosterone-antagonists in patients with myocardial infarction.
- Author
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Shore, Supriya, Maddox, Thomas M., Tang, Fengming, Jones, Philip G., Lanfear, David E., and Ho, P. Michael
- Published
- 2014
- Full Text
- View/download PDF
48. Clinician Perspectives on Barriers and Enablers to Implementing an Inpatient Oncology Early Warning System: A Mixed-Methods Study.
- Author
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Lyons, Patrick G., Chen, Vanessa, Sekhar, Tejas C., McEvoy, Colleen A., Kollef, Marin H., Govindan, Ramaswamy, Westervelt, Peter, Vranas, Kelly C., Maddox, Thomas M., Geng, Elvin H., Payne, Philip R.O., and Politi, Mary C.
- Subjects
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MEDICAL personnel , *CORPORATE culture , *CLINICAL deterioration , *ONCOLOGY , *SEMI-structured interviews , *GENETIC translation - Abstract
PURPOSE: To elicit end-user and stakeholder perceptions regarding design and implementation of an inpatient clinical deterioration early warning system (EWS) for oncology patients to better fit routine clinical practices and enhance clinical impact. METHODS: In an explanatory-sequential mixed-methods study, we evaluated a stakeholder-informed oncology early warning system (OncEWS) using surveys and semistructured interviews. Stakeholders were physicians, advanced practice providers (APPs), and nurses. For qualitative data, we used grounded theory and thematic content analysis via the constant comparative method to identify determinants of OncEWS implementation. RESULTS: Survey respondents generally agreed that an oncology-focused EWS could add value beyond clinical judgment, with nurses endorsing this notion significantly more strongly than other clinicians (nurse: median 5 on a 6-point scale [6 = strongly agree], interquartile range 4-5; doctors/advanced practice providers: 4 [4-5]; P =.005). However, some respondents would not trust an EWS to identify risk accurately (n = 36 [42%] somewhat or very concerned), while others were concerned that institutional culture would not embrace such an EWS (n = 17 [28%]). Interviews highlighted important aspects of the EWS and the local context that might facilitate implementation, including (1) a model tailored to the subtleties of oncology patients, (2) transparent model information, and (3) nursing-centric workflows. Interviewees raised the importance of sepsis as a common and high-risk deterioration syndrome. CONCLUSION: Stakeholders prioritized maximizing the degree to which the OncEWS is understandable, informative, actionable, and workflow-complementary, and perceived these factors to be key for translation into clinical benefit. Mixed-methods research explicates design priorities for hospital-based oncology early warning systems. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
49. MI PATIENTS WITH NON-OBSTRUCTIVE CAD APPEAR TO HAVE SIMILAR OUTCOMES AS MI PATIENTS WITH OBSTRUCTIVE CAD: INSIGHTS FROM THE TRIUMPH STUDY
- Author
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Maddox, Thomas M., Reid, Kimberly J., Ho, P. Michael, Tsai, Thomas T., Spertus, John A., and Rumsfeld, John S.
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- 2011
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50. Big data analytics to improve cardiovascular care: promise and challenges.
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Rumsfeld, John S., Joynt, Karen E., and Maddox, Thomas M.
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BIG data , *CARDIOVASCULAR disease prevention , *MEDICAL equipment , *MEDICAL care , *PUBLIC health , *CARDIOVASCULAR disease treatment , *DATABASES , *MEDICAL quality control , *STATISTICS , *DATA analysis , *TREATMENT effectiveness , *STATISTICAL models - Abstract
The potential for big data analytics to improve cardiovascular quality of care and patient outcomes is tremendous. However, the application of big data in health care is at a nascent stage, and the evidence to date demonstrating that big data analytics will improve care and outcomes is scant. This Review provides an overview of the data sources and methods that comprise big data analytics, and describes eight areas of application of big data analytics to improve cardiovascular care, including predictive modelling for risk and resource use, population management, drug and medical device safety surveillance, disease and treatment heterogeneity, precision medicine and clinical decision support, quality of care and performance measurement, and public health and research applications. We also delineate the important challenges for big data applications in cardiovascular care, including the need for evidence of effectiveness and safety, the methodological issues such as data quality and validation, and the critical importance of clinical integration and proof of clinical utility. If big data analytics are shown to improve quality of care and patient outcomes, and can be successfully implemented in cardiovascular practice, big data will fulfil its potential as an important component of a learning health-care system. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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