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Las enfermedades genéticas cada vez se vuelven más comunes en la sociedad y aunque algunas presentan una incidencia más alta que otras, es necesario que el Sistema de Salud cuente con el equipo multidisciplinario para poder intervenir en cada caso de forma específica y así brindar una atención idónea, considerando la calidad de vida de los pacientes. El Síndrome de Treacher Collins, es un trastorno congénito que se caracteriza por la presencia de deformidades cráneo faciales, actualmente en el Ministerio de Salud Pública del Ecuador la enfermedad está reconocida como una discapacidad múltiple en virtud de los déficits que los pacientes pueden presentar a lo largo de su vida, sin embargo, no cuenta con una ponderación adecuada debido a la inexistencia de datos epidemiológicos registrados en el país. En el siguiente artículo se describe el caso de una persona con Síndrome de Treacher Collins, además se exponen las necesidades de los pacientes que padecen de anomalías genéticas y su accesibilidad a los centros médicos. Las personas que presentan trastornos genéticos muchas veces son víctimas de discriminación y malos tratos dentro del sistema de salud pública, limitando la asequibilidad médica que se les pueda brindar, llegando a desgastar al sujeto que padece de la enfermedad, abandonando muchas veces el sistema de salud pública, con las consecuencias que esto acarrea.

In Spanish, tener que and haber que + infinitive are modal periphrases that convey deontic meanings. The present investigation analyzes these periphrases as variants used in diverse communicative settings by different kinds of participants, acting as either speakers/writers or addressees. Tener que + infinitive tends to appear in those contexts where a more striking implication or unavoidable recommendation is needed. Haber que + infinitive is used more in a wide range of genres promoting a desubjectivizing-deontic meaning. As for the sex/gender of the participants, men more frequently use tener que + infinitive, whereas women tend to employ haber que + infinitive. The latter feature was also found to be significant when the sex/gender of the addressee is unknown; also, tener que + infinitive resulted more frequently in texts to be read or listened by women. The sociolinguistic distribution of the meanings conveyed by each periphrasis helps to delineate communicative styles based on the objectivity-subjectivity dimension.

Circulating Tumor Cells (CTCs) are considered a prognostic marker in pancreatic cancer. In this study we present a new approach for counting CTCs and CTC clusters in patients with pancreatic cancer using the IsofluxTM System with the Hough transform algorithm (Hough-IsofluxTM). The Hough-IsofluxTM approach is based on the counting of an array of pixels with a nucleus and cytokeratin expression excluding the CD45 signal. Total CTCs including free and CTC clusters were evaluated in healthy donor samples mixed with pancreatic cancer cells (PCCs) and in samples from patients with pancreatic ductal adenocarcinoma (PDAC). The IsofluxTM System with manual counting was used in a blinded manner by three technicians who used Manual-IsofluxTM as a reference. The accuracy of the Hough-IsofluxTM approach for detecting PCC based on counted events was 91.00% [84.50, 93.50] with a PCC recovery rate of 80.75 ± 16.41%. A high correlation between the Hough-IsofluxTM and Manual-IsofluxTM was observed for both free CTCs and for clusters in experimental PCC (R2 = 0.993 and R2 = 0.902 respectively). However, the correlation rate was better for free CTCs than for clusters in PDAC patient samples (R2 = 0.974 and R2 = 0.790 respectively). In conclusion, the Hough-IsofluxTM approach showed high accuracy for the detection of circulating pancreatic cancer cells. A better correlation rate was observed between Hough-IsofluxTM approach and with the Manual-IsofluxTM for isolated CTCs than for clusters in PDAC patient samples.

El discurso publicitario tiene como función primordial la persuasión para promover el consumo. Son muchas las formas lingüísticas que conducen a cumplir tal objetivo, entre las cuales destaca el uso de la segunda persona del singular ('tú'), puesto que es la persona que más claramente indexa al interlocutor o audiencia. En este trabajo se analizará el uso de la segunda persona del singular 'tú' con función objetivadora en el discurso publicitario, esto es, cuando la referencia no solo incluye al interlocutor o audiencia, sino, también, a la primera persona, que en el caso del discurso publicitario se entiende como participante primario o secundario. El significado objetivador de la segunda persona es gradual y en esa distinción los constructores de espacios mentales, tales como cuando, si y otros elementos temporales, resultan determinantes. La ausencia de constructores promueve el significado objetivador, mientras que su presencia contribuye a la creación del valor que denominamos objetivador +. Estos significados se analizarán en diversos tipos de anuncios y ámbitos comunicativos. Los resultados indican que el significado objetivador de la segunda persona del singular ('tú') se construye con mayor frecuencia mediante la ausencia de constructores de espacios mentales en todos los tipos de texto y ámbito. En cambio, la presencia de constructores de espacios mentales es mayor en ciertos textos y ámbitos, con lo cual el contenido se presenta de forma general o universal.

INTRODUCTION: In the current era of personalized medicine, liquid biopsy has acquired a relevant importance in patient management of advanced stage non-small cell lung cancer (NSCLC). As a matter of fact, liquid biopsy may supplant the problem of inadequate tissue for molecular testing. The term 'liquid biopsy' refers to a number of different biological fluids, but is most clearly associated with plasma-related platforms. It must be taken into account that pre-analytical processing and the selection of the appropriate technology according to the clinical context may condition the results obtained. In addition, novel clinical applications beyond the evaluation of the molecular status of predictive biomarkers are currently under investigation. AREAS COVERED: This review summarizes the available evidence on pre-analytical issues and different clinical applications of liquid biopsies in NSCLC patients. EXPERT OPINION: Liquid biopsy should be considered not only as a valid alternative but as complementary to tissue-based molecular approaches. Careful attention should be paid to the optimization and standardization of all phases of liquid biopsy samples management in order to determine a significant improvement in either sensitivity or specificity, while significant reducing the number of 'false negative' or 'false positive' molecular results.

Professional drivers are a group susceptible to sleep problems or incorrect rest patterns resulting from work stress that causes alterations in biological stress markers, such as cortisol, or in cardiovascular parameters that show a state of physiological hyper-activation. The current research objective was to adapt and validate the Groningen Sleep Scale (Meijman et al., 1990) in a Spanish population. We analysed its internal structure, reliability and evidence of validity. The participants in this study were 372 drivers (93.4% men, 6.6% women), with a mean age of 40.9 (SD = 10.54), obtained through non-probabilistic sampling. The SPSS 23.0 and AMOS (5.0) programs were used. With the confirmatory factor analysis (CFA) of the AMOS program (5.0), the indicators NFI = 0.902; TLI = 0.844; CFI = 0.913; RMSEA = 0.129 were obtained and showed an acceptable adjustment of the unifactorial model with 8 items. Adequate reliability (0.90) and appropriate evidence of validity with TDS-38, MBI-GS, Irritation, MP-9, DII, and Trans-18. We can conclude that the Groningen Sleep Scale (GSQS-8) is a reliable and valid instrument, suitable in the Spanish language for evaluating the sleep quality of professional drivers.

Las perifrasis modales haber que y tener que + infinitivo poseen un significado modal inherentemente deontico. La primera, debido a la imposibilidad de admitir un sujeto gramatical y de aparecer conjugada obligatoriamente en tercera persona, se ha clasificado como una de las construcciones impersonales del espanol. En cambio, la segunda permite no solamente la conjugacion en las distintas personas gramaticales, sino tambien en diversos tiempos verbales. Esto da lugar a valores diferenciados de la deonticidad; mientras que la construccion haber que + infinitivo (conjugada con mayor frecuencia en presente de indicativo) presenta la obligacion como instruccion, recomendacion o consejo, la perifrasis tener que + infinitivo orienta la obligacion hacia lo inevitable, forzoso o normativo. En este trabajo se realizara una comparacion del uso de estas dos perifrasis como recursos que contribuyen a la creacion de estilos comunicativos basados en la (de)subjetivacion, los cuales se distribuyen de forma desigual entre distintos participantes y variadas situaciones comunicativas.

Objectives. Stress maintained over time leads to a state of exhaustion known as burnout syndrome. This syndrome constitutes an occupational health problem, leading to high absenteeism. It can also mean that workers come to the workplace feeling unwell, which increases occupational collisions and injuries at work. In this study, we developed a predictive model of burnout in professional drivers using the following indicators: age, hours worked, seniority, educational level, fatigue, personality, attitudes toward driving, safety behaviors in the vehicle, and work characteristics and content. Method. A total of 523 professional drivers from different transport sectors, obtained through non-probability sampling, participated in the study. We used SPSS version 25.0 to analyze the data. Results. We determined the predictive capacity of certain variables that affect drivers and cause burnout. Exhaustion can be predicted with fatigue (48.8%), professional efficiency with emotional stability (39.8%) and cynicism with lack of motivation (28%) as the best predictors. Conclusions. The results contribute to a better knowledge of those factors that cause burnout in professional drivers. It is important to design individual interventions to reduce burnout, which would help reduce sick leave and possible collisions, in addition to providing greater well-being for drivers.

The study objective is to create a scale specifically for measuring driver fatigue and to analyze the scale's psychometric properties. The participants were 518 Spanish drivers. We carried out an exploratory factor analysis (EFA) and the first subsample obtained a single-item solution (eight items). We then performed a confirmatory factor analysis (CFA) with a second subsample. The results were root mean square error of approximation (rmsea) = 0.05, comparative fit index (CFI) = 0.94 and Tucker-Lewis index (TLI) = 0.92, which corroborates the previous results and maintains the same number of elements. The resulting dimension shows good reliability. The scale scores were then related to several external correlates and other scales, and showed good convergence and criteria validity. The results indicate that the scale for assessing work fatigue specifically in professional drivers - driver fatigue (DF-8) - is a reliable and valid instrument.

In Spanish, the second-person singular tu may convey two meanings: the first one indexes a singular interlocutor or addressee (deictic) and the other one is non-deictic, meaning that both speaker and listener(s) become referents of the second person. Speakers move from they personal sphere and what they are saying is presented as being of general interest, involving not only the speakers, but also the audience, therefore, it tends towards objectivity. Such usage has been labelled as objectivizing. This meaning is a matter of gradualness; it may be more personal or closer to the speaker (objectivizing) or it may be presented as a fact universally shared (objectivizing +). The absence of any temporal marker gives rise to the just objectivizing meaning, while their presence will imply a step forward and mark the reference as objectivizing +. Both variants are unevenly distributed across diverse kind of texts and participants. The objectivizing variant is used to present more personal or subjective content and it is used in all kinds of texts and by all kinds of participants. The objectivizing + variant serves to promote a kind of universal shared state of things, very useful in certain communicative areas like advertising and social media.

We describe a versatile, portable, and simple platform that includes a microfluidic electrochemical immunosensor for prostate-specific antigen (PSA) detection. It is based on the covalent immobilization of the anti-PSA monoclonal antibody on magnetic microbeads retained in the central channel of a microfluidic device. Image flow cytometry and scanning electron microscopy were used to characterize the magnetic microbeads. A direct sandwich immunoassay (with horseradish peroxidase-conjugated PSA antibody) served to quantify the cancer biomarker in serum samples. The enzymatic product was detected at -100 mV by amperometry on sputtered thin-film electrodes. Electrochemical reaction produced a current proportional to the PSA level, with a linear range from 10 pg mL(-1) to 1500 pg mL(-1). The sensitivity was demonstrated by a detection limit of 2 pg mL(-1) and the reproducibility by a coefficient of variation of 6.16%. The clinical performance of this platform was tested in serum samples from patients with prostate cancer (PCa), observing high specificity and full correlation with gold standard determinations. In conclusion, this analytical platform is a promising tool for measuring PSA levels in patients with PCa, offering a high sensitivity and reduced variability. The small platform size and low cost of this quantitative methodology support its suitability for the fast and sensitive analysis of PSA and other circulating biomarkers in patients. Further research is warranted to verify these findings and explore its potential application at all healthcare levels., Universidad Nacional de San Luis PROICO 22/Q241, ANPCyT PICT 2018-04443 PICT-2015-2246 PICT-2015-1575 PICT-2014-1184 PICT-2014-0375 PICT-2018-04443, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) PIP 11220150100004CO, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government (Granada, Spain), ISCIII Health Research Institute P17/00989, La Caixa Foundation, Health and Family Secretariat of the Andalusian Regional Government, Spanish Government, H2020-MSCA-IF-2019-895664

Background: A worker’s work habits can affect their health, both physically and psychologically. Negative results have been associated with work demands (stress, anxiety and depression). Objective: In the present research we carried out a predictive study of work addiction by applying three questionnaires on depression and anxiety. Methods: In this study, the participants were 332 workers, obtained through non-probabilistic sampling. The FACTOR (version 7.2) and SPSS 23.0 programs were used. Results: The results of the correlation analysis show both positive and negative associations with the variables studied. We conclude that work addiction variables can predict anxiety and depression because we found that two variables predict 18.3% of depression and 20.3% of anxiety, which are feelings generated by work and excessive work. Conclusion: It can be concluded that feelings generated by work and excessive work predict anxiety and depression, thus the present research helps to broaden knowledge on work addiction, promoting a healthy lifestyle and prevent absenteeism.

Background: Professional drivers drive for many hours without rest. This factor, in addition to the characteristics of the job, the vehicle, the environment and the driver, causes driver fatigue. F...

Objetivo: Identificar la prevalencia y factores asociados al traumatismo craneoencefálico en adultos entre 20 a 50 años que acuden al Servicio de Emergencia del Hospital Vicente Corral Moscoso, periodo Enero - Junio 2018. Metodología: Estudio retrospectivo, cuantitativo y descriptivo de corte transversal, el universo está constituido por 135 pacientes atendidos en el Hospital Vicente Corral Moscoso en el área de emergencia con trauma craneoencefálico, de los cuales se analizaron 100 historias clínicas de pacientes que cumplieron los criterios de inclusión. El instrumento para recolectar datos fue un formulario previamente validado de 9 ítems: las 5 primeras determinaron las variables sociodemográficas, y en los 4 consiguientes se determinaron la gravedad de trauma, mecanismo de trauma, y condiciones del paciente, y para el análisis de los mismos se utilizó el programa Statisyical Product and Service Solutions para Windows. Resultados: El 90% correspondiendo al trauma leve. El grupo etario más afectado fue de 20-30 años, predominando el sexo masculino en un 71%, el nivel de instrucción de los pacientes analizados fue secundario 42%, estado civil soltero(a) 44%, con mayor predominio en pacientes de condición socioeconómica media 77%, la causa principal del traumatismo craneoencefálico fue los accidentes de tránsito 34%, y fallecieron el 1% de la población estudiada. Conclusión: La frecuencia de traumatismo craneoencefálico es un problema de salud elevado en el contexto epidemiológico en el Hospital Vicente Corral Moscoso de la ciudad de Cuenca, por eso es necesario capacitar a toda la población sobre cuidados al momento de realizar actividades y la utilización de medidas de protección respectivas según la actividad que realicen.

Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step. Until now, strategies for the identification of high-risk subjects have been based on low-sensitivity and low-specificity assays. However, new liquid biopsy assays, “the Rosetta Stone of the new biomedicine era,” with the ability to identify circulating biomarkers with unprecedented sensitivity, promise to revolutionize cancer management. This review focuses on novel liquid biopsy approaches and the applications to cancer interception. Cancer interception involves the identification of biomarkers associated with developing cancer, and includes genetic and epigenetic alterations, as well as circulating tumor cells and circulating epithelial cells in individuals at risk, and the implementation of therapeutic strategies to prevent the beginning of cancer and to stop its development. Large prospective studies are needed to confirm the potential role of liquid biopsy for early detection of precancer lesions and tumors.

En español existen distintos recursos para expresar la impersonalidad o la desubjetivación del discurso, bien sea a través de la no formulación del sujeto, bien sea a través de la ocultación o indeterminación del agente de la acción o evento. En este trabajo se analiza el uso de dos formas desubjetivadoras: el clítico 'se' y la perífrasis 'haber que' + infinitivo. Los resultados muestran que, en función de la prominencia cognitiva, con estas variantes se crean distintos significados que dan lugar a estilos comunicativos diferenciados en distintos textos y géneros de variada naturaleza.

Resumen Contexto A pesar de ser una demostrada fuente de biomarcadores, la biopsia liquida aun no ha conseguido dar el paso a la practica clinica habitual en pacientes con cancer de prostata. Pocos biomarcadores se someten a una adecuada validacion, prospectiva e independiente, de su valor predictivo o pronostico y ello resulta en una falta de resultados con capacidad de traslacion real a la clinica de los diferentes test disponibles. Objetivo Realizar una sintesis, clinicamente pragmatica, de la evidencia cientifica actual sobre la biopsia liquida sanguinea en cancer de prostata. Adquisicion de la evidencia Revision no sistematica de la literatura, acotando la busqueda a trabajos sobre biopsia liquida de origen sanguineo en cancer de prostata. Se seleccionaron preferentemente aquellos trabajos en los cuales se estudian end-points clinicos aplicados al cancer de prostata. Sintesis de la evidencia Las formas de biopsia liquida mas avanzadas en terminos clinicos son las celulas tumorales circulantes (CTC) y el ADN tumoral circulante (ADNtc). Tanto CTC como ADNtc han demostrado su valor pronostico en enfermedad metastasica. La determinacion de ARV7 constituye el primer biomarcador predictivo de la enfermedad. Su traslacion a la practica clinica habitual pasa por la estandarizacion metodologica y la adecuada validacion clinica de las distintas formas de deteccion disponibles. La deteccion de CTC en estadios iniciales de la enfermedad depende aun de la optimizacion de los metodos de deteccion y del desarrollo de la caracterizacion biologica de estas celulas. La informacion biologica aportada por CTC y ADNtc es distinta; por ello, el estudio de su adecuada conjuncion es objeto de la investigacion mas actual. Conclusiones La ausencia de protocolos y estandares metodologicos es el factor limitante para llegar a conclusiones de impacto clinico. Por ello, el consenso y la unificacion de criterios constituyen el verdadero desafio a corto plazo para la biopsia liquida.

Context Despite being a validated source of biomarkers, liquid biopsy has not yet succeeded in becoming part of the standard clinical practice in prostate cancer patients. Few biomarkers undergo adequate validation, prospective and independent, of their predictive and/or prognostic value, which results in a lack of the different available tests in the clinical practice. Objective To carry out a pragmatic synthesis of current scientific evidence on liquid biopsy for prostate cancer patients. Evidence acquisition Non-systematic literature review, narrowing the search to papers on liquid biopsy from blood samples in prostate cancer patients. We mainly selected works evaluating clinical endpoints in prostate cancer. Evidence synthesis The most clinically advanced forms of liquid biopsy are circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Both CTCs and ctDNA have demonstrated their prognostic value in metastatic disease. ARV7 determination is the first predictive biomarker of the disease. Its implementation into routine clinical practice requires methodological standardization and adequate clinical validation of the different available ways to detect it. The detection of CTCs in the early stages of the disease still depends on the optimization of the diagnostic methods and on the development of the biological characterization of these cells. The biological information provided by CTCs and ctDNA is different; therefore, the study of its adequate combination is the object of cutting-edge research. Conclusions The absence of protocols and methodological standards is the limiting factor when aiming to reach conclusions that could have a potential impact on clinical practice. Therefore, the real short-term challenge for liquid biopsy is the establishment of consensus and common criteria. Resumen Contexto A pesar de ser una demostrada fuente de biomarcadores, la biopsia liquida aun no ha conseguido dar el paso a la practica clinica habitual en pacientes con cancer de prostata. Pocos biomarcadores se someten a una adecuada validacion de su valor predictivo y/o pronostico, prospectiva e independiente,; y ello resulta en una falta de traslacion real a la clinica de los diferentes test disponibles. Objetivo Realizar una sintesis, clinicamente pragmatica, de la evidencia cientifica actual sobre la biopsia liquida sanguinea en cancer de prostata. Adquisicion de la evidencia revision no sistematica de la literatura acotando la busqueda a trabajos sobre biopsia liquida de origen sanguineo en cancer de prostata. Se seleccionan preferentemente aquellos trabajos en los cuales se estudian end-points clinicos aplicados al cancer de prostata. Sintesis de la evidencia Las formas de biopsia liquida mas avanzadas en terminos clinicos son las celulas tumorales circulantes (CTCs) y el ADN tumoral circulante (ctDNA). Tanto CTCs como ctDNA han demostrado su valor pronostico en enfermedad metastasica. La determinacion de ARV7 constituye el primer biomarcador predictivo de la enfermedad. Su traslacion a la practica clinica habitual pasa por la estandarizacion metodologica y la adecuada validacion clinica de las distintas formas de deteccion disponibles. La deteccion de CTCs en estadios iniciales de la enfermedad depende aun de la optimizacion de los metodos de deteccion y del desarrollo de la caracterizacion biologica de estas celulas. La informacion biologica aportada por CTCs y ctDNA es distinta; por ello, el estudio de su adecuada conjuncion es objeto de la investigacion mas actual. Conclusiones La ausencia de protocolos y estandares metodologicos es el factor limitante para llegar a conclusiones de impacto clinico. Por ello, el consenso y la unificacion de criterios constituyen el verdadero desafio a corto plazo para la biopsia liquida.

In this work, we present a microfluidic amperometric immunosensor for cancer biomarker claudin7 (CLD7) determination in circulating extracellular vesicles (EVs) as well as its validation in colorectal cancer (CC) patients. The device is based on synthetized nanosized MIL-125-NH

Patients with Osteogenesis Imperfecta are, due to their pathology, candidates to require more than one surgical intervention and therefore, to be anesthetized. A bibliographic review is carried out regarding a clinical case, in search of the pathophysiological alterations associated with this entity that are most frequently found in this population, and their potential anesthetic implications

Organizational culture is a central concept in research due to its importance in organizational functioning and suffering of employees. To better manage suffering, it is necessary to better understand the intrinsic characteristics of each type of culture and also its relationships with the environment. In this study, we used the multiple regression analysis to analyze the capacity of eight environment variables, five business strategies, and eight organizational competencies to predict the presence of Clan, Market, and Hierarchy cultures (Cameron and Quinn, 1999) in a subsample of Spanish managers (n1 = 362) and a subsample of Peruvian managers (n2 = 1,317). Contrary to what most of the literature suggests, we found almost no relationship between the environmental variables and the culture types. Strategy and competencies, in contrast, do have a significant predictive capacity, showing 9 links with the Clan culture, 7 with the Hierarchy culture, and 10 with the Market culture. In conclusion, this study has found the important characteristics of the types of organizational culture that could be useful to better manage the suffering of employees.

Objectives. In health and safety at work, two main groups of causes of occupational accidents have been identified: unsafe conditions or technical factors; and the causes related to safe behavior or the human factor. The objective of this study is to analyze the predictive variables (emotional intelligence, personality, impulsivity and safety of the work environment) for three factors of the CONS-32 scale (criterion variables: use of protections, personal risk behavior and personal physical workload) in the construction sector. Methods. Using a sample of 256 Spanish workers from this sector, we analyzed the significant correlations between the three criterion variables and a set of variables extracted from various instruments, as well as the regression models that explain most of the variance. Results. The results show that the main predictive variables that explain the three factors are those related to responsibility as a personality trait, impulsivity and safety of the work environment. Conclusions. Based on the empirical evidence found, the most explanatory factor in all cases is safety climate in the work environment.

Objectives. Several studies have shown that one of the most common causes of collision is driver fatigue since fatigue causes drowsiness while driving and this decreases the driver's ability to maneuver the vehicle and increases the probability of their nodding off and falling asleep at the wheel. This may be due to a variety of personal reasons and specific factors connected to working conditions. In the present work we therefore intend to develop a predictive model for fatigue in professional drivers using the following indicators: age, gender, personality, burnout, characteristics and job content. Method. The participants were 516 professional drivers from different transport sectors, obtained through non-probabilistic sampling. SPSS version 25.0 was used for data analysis. Results. The predictive capacity of a number of variables that affect drivers by causing fatigue is determined. Fatigue can be predicted through certain variables, with the best predictor being exhaustion (48.8%). Conclusions. This research contributes to a greater knowledge of the factors that produce fatigue in professional drivers. It highlights the importance of designing interventions to reduce the incidence of fatigue, resulting in greater well-being for the driver and a lower incidence of collisions.

[Simple Summary] Effective biomarkers are needed to enable personalized medicine for pancreatic cancer patients. This study analyzes the prognostic value, in early pancreatic cancer, of circulating tumor cells and clusters from the central venous catheter and portal blood. Circulating tumor cells were isolated using an immunomagnetic selection and were detected by microscopy using immunocytochemistry staining. In conclusion, the circulating tumor cell number in portal blood identifies a death risk in patients with early pancreatic cancer., [Abstract] Background. Effective biomarkers are needed to enable personalized medicine for pancreatic cancer patients. This study analyzes the prognostic value, in early pancreatic cancer, of single circulating tumor cell (CTC) and CTC clusters from the central venous catheter (CVC) and portal blood (PV). Methods. In total, 7 mL of PV and CVC blood from 35 patients with early pancreatic cancer were analyzed. CTC were isolated using a positive immunomagnetic selection. The detection and identification of CTC were performed by immunocytochemistry (ICC) and were analyzed by Epi-fluorescence and confocal microscopy. Results. CTC and the clusters were detected both in PV and CVC. In both samples, the CTC number per cluster was higher in patients with grade three or poorly differentiated tumors (G3) than in patients with well (G1) or moderately (G2) differentiated. Patients with fewer than 185 CTC in PV exhibited a longer OS than patients with more than 185 CTC (24.5 vs. 10.0 months; p = 0.018). Similarly, patients with fewer than 15 clusters in PV showed a longer OS than patients with more than 15 clusters (19 vs. 10 months; p = 0.004). These significant correlations were not observed in CVC analyses. Conclusions. CTC presence in PV could be an important prognostic factor to predict poor prognosis in early pancreatic cancer. In addition, the number of clustered-CTC correlate to a tumor negative differentiation degree and, therefore, could be used as a diagnostic biomarker for pancreatic cancer., This research was funded by Carlos III Health Institute (Health Research Fund) grant number PI16/01465 and PI19/01821 (Co-financed by the European Regional Development Fund “A way to make Europe”).

El objetivo de este estudio fue realizar un estudio correlacional-predictivo de las variables antecedentes de la Pasión por el trabajo. Método: Los participantes han sido 513 trabajadores (48,1 % hom- bres, 51,9 % mujeres), obtenidos mediante un muestreo no probabilístico. Se han utilizado los programas FACTOR (versión 7.2) y SPSS 20.0. Resultados: se determina la capacidad predictiva de variables como Persona- lidad, Engagement, Autoeficacia, ICO, Satisfacción por la vida y Estilo de vida sobre la Pasión por el trabajo. Conclusiones: La Pasión por el Traba- jo se puede predecir de la siguiente manera: La Pasión Armoniosa de for- ma directa con las variables Dedicación, Crecimiento, Actividad física, Sa- tisfacción con la vida y Responsabilidad excesiva, y de manera inversa con el Vigor. Mientras que la Pasión Obsesiva a través de las variables Absor- ción y Responsabilidad excesiva y de manera negativa la Satisfacción con la vida, la Apertura a la experiencia y la Amabilidad. The aim of this study was to conduct a correlational- predictive study of the antecedent variables of Passion towards Work. Method: The participants were 513 workers (48.1% male, 51.9% female), obtained through non-probability sampling. We used the FACTOR pro- grams (7.2 version) and SPSS 20.0. Results: We found that variables such as Personality, Engagement, Self-efficacy, obsessive-compulsive component COI, Life satisfaction and Lifestyle were predictive of Passion towards Work. Conclusions: Passion towards Work can be predicted as follows: The variables Dedication, Growth, Physical activity, Satisfaction with life and Excessive responsibility were direct predictors of Harmonious Passion whereas Vigor was an inverse predictor. Similarly, the variables Absorption and Excessive responsibility were predictors of Obsessive Passion, where- as Satisfaction with life, Openness to experience and Kindness were nega- tive predictors.

Estudios recientes has sugerido que hay relación entre algunas variables de personalidad y la adicción al trabajo. En el presente trabajo nos hemos planteado el objetivo de realizar un estudio Predictivo de las varia- bles antecedentes del Work Craving a través de las variables Impulsividad, Personalidad, Perfeccionismo, Autoestima y Autoeficacia.: Los participan- tes han sido 332 trabajadores, obtenidos mediante un muestreo no proba- bilístico. Para analizar los datos se ha utilizado el programa SPSS 23.0. Los resultados del análisis de correlación nos muestran asociaciones tanto posi- tivas como negativas con las variables estudiadas. El análisis de regresión determina la capacidad predictiva de las variables Estabilidad emocional, Perfeccionismo y Autoestima que explican el 24.40 % de la varianza de los Sentimientos Generados por el Trabajo (WCS.FW). Y las variables Estabi- lidad emocional y Autoestima explican el 14.0 % de la Necesidad de traba- jar (WCS.NW). Se puede concluir que el Work Craving puede predecirse a través de determinadas variables (Estabilidad emocional, Perfeccionismo y Autoestima), contribuyendo la presente investigación a un mayor conoci- miento de la Adicción al Trabajo. Los resultados poseen implicaciones prácticas importantes que debe considerarse para la gestión estratégica ade- cuada de los recursos humanos dentro de las organizaciones. Los más no- tables entre ellos son la necesidad de promover la mejora de la autoestima y la estabilidad emocional. Recent studies have suggested a relationship between certain personality variables and work addiction. In the present work we conduct a predictive study of the background variables of work craving through the variables Impulsivity, Personality, Perfectionism, Self-esteem and Self- efficacy. The participants were 332 workers obtained by non-probability sampling. We used the SPSS 23.0 program. The results of the correlation analysis show positive and negative associations with the variables studied. The regression analysis determines the predictive capacity of variables Emotional Stability, Perfectionism and Self-esteem account for 24.40% of the variance of Feelings Generated by Work (WCS.FW). And the predic- tor variables Emotional stability and Self-esteem account for 14.0% of the Need to Work (WCS.NW). It can be concluded that Work craving can be predicted through certain variables (Emotional Stability, Perfectionism and Self-esteem). This research contributes to greater knowledge of work ad- diction. The results have important practical implications to work that should be considered for the appropriate strategic management of human resources within organizations. The most notable among these are the need to promote the enhancement of self-esteem and emotional stability