42 results on '"Moss, Steven J."'
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2. The Biosynthetic Gene Cluster of the Maytansinoid Antitumor Agent Ansamitocin from Actinosynnema pretiosum
3. Fluorometabolite biosynthesis in Streptomyces cattleya
4. Recombinant strains for the enhanced production of bioengineered rapalogs
5. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
6. COMMUNITY-BASED TRADING MECHANISMS TO REDUCE POLLUTING AIR EMISSIONS AND ADDRESS GLOBAL WARMING
7. BC265: A Nonquinone Ansamycin Hsp90 Inhibitor Developed Using Biosynthetic Medicinal Chemistry
8. Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055 : Cluster Analysis and Assignment of Functions
9. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation
10. Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya
11. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of 'glycolate' units into ansamitocin and soraphen A
12. Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
13. Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055Cluster Analysis and Assignment of Functions
14. Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis
15. Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency
16. Identification of asm19 as an acyltransferase attaching the biologically essentials ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate
17. Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual 'glycolate' chain extension unit in ansamitocin biosynthesis
18. Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis
19. Structure guided design of improved anti-proliferative rapalogs through biosynthetic medicinal chemistry
20. Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristics
21. Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection
22. Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family
23. Total Synthesis of Chloptosin: A Dimeric Cyclohexapeptide
24. An Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis
25. Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors
26. Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain
27. Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues
28. Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids
29. Mutasynthesis of Rapamycin Analogues through the Manipulation of a Gene Governing Starter Unit Biosynthesis
30. Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity
31. Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
32. ChemInform Abstract: Fluoroacetaldehyde: A Precursor of Both Fluoroacetate and 4‐Fluorothreonine in Streptomyces cattleya.
33. Fluoroacetaldehyde: a precursor of both fluoroacetate and 4-fluorothreonine in Streptomyces cattleya
34. Evidence for an octanoate synthase operating during the biosynthesis of piliformic acid in Poronia piliformis
35. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects
36. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
37. Silent Retreat.
38. Identification of Asm 19 as an Acyltransferase Attaching the Biologically Essential Ester Side Chain of Ansamitocins Using N-Desmethyl-4-,5-desepoxymaytansinol, Not Maytansinol, as Its Substrate.
39. Identification of a Set Genes Involved in thr Formation of the Substrate for the Incorporation of the Unusual 'Glycolate' Chain Extension Unit in Ansamitocin Biosynthesis.
40. Total synthesis of chloptosin: a dimeric cyclohexapeptide.
41. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.
42. Biosynthetic engineering of natural products for lead optimization and development.
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