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Naši rezultati ukazuju na moguću povezanost aktivnosti PChE s metaboličkim sindromom i razvojem kardiovaskularnih bolesti. Iako uzročno-posljedična veza između aktivnosti PChE i pojedinih komponenata metaboličkog sindroma još nije razjašnjena, ukoliko se ove pretpostavke pokažu točnima, aktivnost PChE mogla bi postati zasebni pokazatelj stupnja inzulinske rezistencije i rizika od razvoja ateroskleroze.

There is wide diversity of etiologies of perforation classified as nontraumatic spontaneous small intestine perforation.

Fabry disease is a rare, X-linked recessive lysosomal storage disease caused by a deficiency of the lysosomal enzyme α-galactosidase A.

Pompse disease or acid maltase deficiency or glycogenosis type II is rare lysosomal storage disease due to the mutations of acid alpha-glucoside gene (GAA) on chromosome 17q25.

Loše životne navike se gomilaju u bolesnika sa arterijskom hipertenzijom. Nadamo se kako će CRASH inicijativa povećati svjesnost i poboljšati liječenje u bolesnika sa povišenim kardiovaskularnim rizikom.

Fabryeva bolest pripada skupini rijetkih nasljednih metaboličkih bolesti, iz grupe lizosomskih bolesti nakupljanja. Prevalencija ove bolesti je u Europskoj populaciji 1:117.000. bolest je posljedica nedostatka enzima alfa-galaktozidaze A te nakupljanja glukosfingolipida, prvenstveno globotriazilceramida (GL-3) u različitim tkivima.

This study assessed the level of physical activity in overweight and obese subjects, and overweight and obese patients with Type 2 diabetes mellitus (T2DM). It also compared their physical activity level with that of the general population and investigated benefits of physical activity on anthropometric and metabolic parameters and blood pressure in the studied groups of patients using Baecke's questionnaire and the Lipid Research Clinics Physical Activity (LRC PA) questionnaire. The two questionnaires were also compared in the evaluation of benefits. Physical activity level and other parameters (body weight, body height, body mass index, waist-to- hip ratio, systolic and diastolic blood pressure, lipoprotein and creatinine concentrations in the blood, concentration of fasting glucose and HbA1c in the blood, albuminuria-to-creatinuria ratio) of 136 subjects and their relationships were investigated during their out-patient visits. No difference in physical activity level was found among the four groups of investigated patients. The comparison between the level of physical activity in the investigated patients and the general population obtained by Baecke's questionnaire revealed a lower sports index in all groups of investigated men and obese women with diabetes mellitus. Our results confirm the benefit of physical activity on a high number of investigated parameters in the studied patients. The Baecke's questionnaire was found to estimate the effects of physical activity on metabolic and anthropometric parameters, as well as blood pressure, better than the LRC PA questionnaire, especially the two-point scoring system. LRC PA and especially Baecke's questionnaires are valuable aids in the estimation of physical activity level and its benefits in overweight and obese patients and patients with T2DM.

This study assesed the level of physical activity in overweight and obese subjects, and overweight and obese patients with Type II diabetes mellitus. It also investigated benefits of physical activity on anthropometric and metabolic parameters and blood pressure in studied groups. Physical activity level, body weight, body height, body mass index, waist-to- hip ratio, blood pressure, lipoprotein, creatinin, glucose and HbA1C concentrations in the blood and albuminuria-to-creatinin ratio of 136 subjects were measured during their out- patient visit. No difference in physical activity was found among the four groups of subjects. However, the level of physical activity of patients with T2DM is significantly lower then the one of general population. The Baecke´s questionnare was found to estimate the effects of physical activity on anthropometric and metabolic parameters and blood pressure better than the LRC PA questionnare. In conclusion both questionnares are valuable aids in the estimation of physical activity level and its benefits in overweight and obese patients with T2DM.

Apolipoprotein E (apo E) polimorfizam jedna je od glavnih čimbenika koji utječu na metabolizam lipoproteina. Tri izoforme apo E (E2, E3, E4) određuju šest različitih genotipova. Svaka izovorma je kodirana s tri različita alela na apo E lokusu kromosoma...