165 results on '"N. Le Moual"'
Search Results
2. Household use of green and home-made cleaning products, wipe form and asthma
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E Pacheco da Silva, G Sit, M Goldberg, B Leynaert, R Nadif, C Ribet, N Roche, M Zins, R Varraso, O Dumas, and N Le Moual
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- 2022
3. Longitudinal associations of household use of cleaning agents and asthma symptoms
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E Pacheco da Silva, M Ngutuka, O Dumas, L Orsi, P Lemire, J Quentin, I Pin, R Varraso, V Siroux, and N Le Moual
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- 2022
4. Dwelling visible mould exposure increased asthma symptom score in the CONSTANCES cohort
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T TSIAVIA, E Fréalle, V Bex, O Dumas, M Goldberg, N Le Moual, C Ribet, N Roche, M Savouré, R Varraso, M Zins, B Leynaert, L Orsi, and R Nadif
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- 2022
5. Occupational exposures, asthma and asthma control in the NutriNet-Sante cohort
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G Sit, R Varraso, L Fezeu, P Galan, F Orsi, E Pacheco Da Silva, M Touvier, S Hercberg, C Paris, N Le Moual, O Dumas, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and École des Hautes Études en Santé Publique [EHESP] (EHESP)
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[SDV]Life Sciences [q-bio] - Abstract
International audience
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- 2022
6. Asthme et expositions aux produits de nettoyage
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N. Le Moual, Orianne Dumas, and Francine Kauffmann
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Public Health, Environmental and Occupational Health - Abstract
Resume But de l’etude L’exposition aux produits de nettoyage est frequente, tant dans le cadre professionnel que domestique. L’objectif de cet article est de faire un etat de la question sur la relation entre l’asthme et les expositions aux produits de nettoyage. Methodes Une revue de la litterature a ete effectuee. Apres une breve presentation des produits de nettoyage ayant potentiellement un effet sur la sante respiratoire, les resultats d’etudes de cas, d’etudes de surveillance et d’etudes epidemiologiques sont synthetises. Resultats Les produits de nettoyage et de desinfection sont composes de nombreux agents chimiques, pouvant etre classes en irritants ou en sensibilisants. Les etudes de surveillance ont mis en avant la place importante de l’exposition aux produits de nettoyage dans l’asthme professionnel ou l’asthme exacerbe par le travail, en particulier dans le secteur de la sante. Dans des etudes epidemiologiques principalement transversales et dans une etude longitudinale prospective, des associations avec l’asthme ont ete mises en evidence pour les professions de sante ou de menage, ou l’exposition aux produits de nettoyage. Des associations avec l’asthme ont le plus souvent ete observees pour l’utilisation d’ammoniac, d’eau de javel et de produits sous forme de spray, lorsque ces informations etaient disponibles. Peu d’etudes ont evalue le role des produits de nettoyage sur des phenotypes d’asthme specifiques. Des associations avec l’asthme non IgE-dependant et l’asthme IgE-dependant ont ete observees. Des travaux methodologiques seraient necessaires pour ameliorer les estimations des expositions aux produits de nettoyage. Les estimations des expositions aux produits de nettoyage specifiques sont le plus souvent basees sur la declaration des sujets, ce qui peut engendrer des biais de declaration differentiels. Discussion et conclusion Il est maintenant etabli que l’exposition aux produits de nettoyage est liee a la fois a l’apparition de l’asthme et a des exacerbations d’asthmes preexistants. Il reste cependant de nombreuses questions sur les produits specifiques impliques et leurs mecanismes d’action. Des methodes d’estimation des expositions plus objectives et applicables a de grandes populations, comme les matrices tâche-exposition, pourraient etre developpees. Des mesures quantitatives seraient utiles pour ameliorer l’estimation des expositions.
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- 2013
7. Development of a job-task-exposure matrix to assess occupational exposure to disinfectants among US nurses
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Carlos A. Camargo, Raphaëlle Varraso, N. Le Moual, Catherine Quinot, Aleta Wiley, Frank E. Speizer, Orianne Dumas, Paul K. Henneberger, Jan Paul Zock, and Marcel Goldberg
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Disinfectant ,Job-exposure matrix ,Frequency of use ,Nurses ,Risk Assessment ,Article ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Occupational Exposure ,Surveys and Questionnaires ,medicine ,Humans ,Prospective Studies ,Information bias ,Asthma ,Aged ,business.industry ,Public Health, Environmental and Occupational Health ,Middle Aged ,medicine.disease ,030210 environmental & occupational health ,United States ,030228 respiratory system ,Assessment methods ,Female ,Occupational exposure ,Risk assessment ,business ,Disinfectants - Abstract
Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. To evaluate disinfectant exposures, we designed job-exposure (JEM) and job-task-exposure (JTEM) matrices, which are thought to be less prone to differential misclassification bias than self-reported exposure. We then compared the three assessment methods: self-reported exposure, JEM and JTEM.Disinfectant use was assessed by an occupational questionnaire in 9073 US female registered nurses without asthma, aged 49-68 years, drawn from the Nurses' Health Study II. A JEM was created based on self-reported frequency of use (1-3, 4-7 days/week) of 7 disinfectants and sprays in 8 nursing jobs. We then created a JTEM combining jobs and disinfection tasks to further reduce misclassification. Exposure was evaluated in 3 classes (low, medium, high) using product-specific cut-offs (eg,30%, 30-49.9%, ≥50%, respectively, for alcohol); the cut-offs were defined from the distribution of self-reported exposure per job/task.The most frequently reported disinfectants were alcohol (weekly use: 39%), bleach (22%) and sprays (20%). More nurses were classified as highly exposed by JTEM (alcohol 41%, sprays 41%, bleach 34%) than by JEM (21%, 30%, 26%, respectively). Agreement between JEM and JTEM was fair-to-moderate (κ 0.3-0.5) for most disinfectants. JEM and JTEM exposure estimates were heterogeneous in most nursing jobs, except in emergency room and education/administration.The JTEM may provide more accurate estimates than the JEM, especially for nursing jobs with heterogeneous tasks. Use of the JTEM is likely to reduce exposure misclassification.
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- 2016
8. Étude des associations entre la pollution atmosphérique et les niveaux de 8-isoprostanes dans l’étude EGEA
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Valérie Siroux, N. Le Moual, Rachel Nadif, Farid Zerimech, A. Havet Berche, Margaux Sanchez, Régis Matran, Bénédicte Jacquemin, and Hélène Huyvaert
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Etat de la question L’asthme touche 300 millions de personnes dans le monde et la pollution atmospherique est l’un des facteurs environnementaux associes a son apparition. Parmi les mecanismes biologiques qui pourraient expliquer cette association, le stress oxydant est fortement suggere. Les 8-isoprostanes (8-iso) sont des marqueurs de dommages tissulaires lies au stress oxydant, pouvant etre doses dans le condensat de l’air expire (CAE). L’objectif de cette etude est double : – confirmer l’association entre la pollution atmospherique et l’asthme actuel ; – etudier l’association entre la pollution atmospherique et les 8-iso et l’association entre les 8-iso et l’asthme actuel, chez l’adulte dans l’etude EGEA. Methodes Les analyses ont concerne 663 participants adultes vus au premier suivi de l’etude epidemiologique des facteurs genetiques et environnementaux de l’asthme (EGEA, http://egeaintranet.vjf.inserm.fr/ ), etude cas-temoin, familiale et multicentrique. La pollution atmospherique (NO 2 , NOx, PM 10 , PM 2,5 et trafic routier) a ete estimee dans le cadre du programme FP7 ESCAPE ( http://www.escapeproject.eu/ ). Les 8-iso ont ete mesures dans le CAE, fluide proche du poumon et recueilli de maniere non invasive. Des modeles lineaires generalises avec prise en compte de la dependance familiale et des modeles mixtes sur la ville ont ete utilises. Resultats L’âge moyen des participants etait de 41,9 ans, 49 % etaient des hommes et 36,2 % avaient un asthme actuel. Les niveaux de pollution etaient disponibles a Paris, Lyon, Grenoble et Marseille et etaient plus eleves a Paris ( p 8-iso ) et des 25 e et 75 e percentiles de 3,25 pg/mL (1,43;7,76). A Paris, la MG 8-iso etait 7 fois plus elevee que dans les trois autres villes ( p n = 368), la MG 8-iso etait de 2,69 pg/mL (1,12;6,78) et elle etait plus elevee chez la femme ( p 95 % ] = 1,10 [1,00;1,19]). Seules les PM 2,5 etaient associees positivement et significativement aux 8-iso (β [IC95 %] = 0,29 [0,06;0,51] ; p = 0,01). Enfin, les 8-iso etaient associes positivement a l’asthme actuel qu’ils soient exprimes en continu (OR [IC95 %] = 1,50 [1,06;2,12]) ou en classes, definies selon la mediane (OR [IC95 %] = 1,57 [1,03;2,40]). Conclusions Cette etude montre pour la premiere fois chez l’adulte une association entre la pollution atmospherique et la [8-iso]. Elle souligne l’interet du CAE en epidemiologie respiratoire, et l’utilite des 8-iso comme marqueurs potentiels de dommages lies a la pollution dans l’asthme.
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- 2017
9. Dietary patterns and asthma in the E3N study
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Françoise Clavel-Chapelon, N. Le Moual, Bénédicte Leynaert, Isabelle Romieu, Marie-Christine Boutron-Ruault, F Kauffmann, and Raphaëlle Varraso
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Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Prevalence ,Diet Surveys ,Article ,Body Mass Index ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,immune system diseases ,Epidemiology ,medicine ,Humans ,030212 general & internal medicine ,Aged ,Asthma ,2. Zero hunger ,business.industry ,Incidence ,Incidence (epidemiology) ,Feeding Behavior ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Diet ,respiratory tract diseases ,3. Good health ,030228 respiratory system ,Physical therapy ,Female ,France ,business ,Body mass index ,Demography ,Cohort study - Abstract
The aim of the present study was to determine dietary patterns and investigate their association with asthma incidence, current asthma and frequent asthma exacerbations. Dietary habits and asthma data were collected from the large E3N study (of French females, mostly teachers). Of the 54,672 females followed-up in 2003, 2,634 reported ever-adulthood asthma, 1,063 reported current asthma, 206 reported frequent asthma attacks (one or more a week), and 628 reported asthma onset between 1993 and 2003. Using principal component analysis, three dietary patterns were identified: the "prudent" pattern (fruits and vegetables); the "Western" pattern (pizza/salty pies, dessert and cured meats); and the "nuts and wine" pattern. Pattern scores were categorised into tertiles, and the incidence and prevalence of asthma was compared between tertiles. After adjustment for confounders, no association of dietary patterns was observed with asthma incidence, ever-asthma or current asthma. The Western pattern was associated with an increased risk of reporting frequent asthma attacks (highest versus lowest tertile odds ratio (OR) 1.79, 95% confidence interval (CI) 1.11-3.73). Increasing scores of the nuts and wine pattern were associated with a decreased risk of reporting frequent asthma attacks (highest versus lowest tertile OR 0.65, 95% CI 0.31-0.96). The results of the present study suggest that overall diet could be involved in frequent asthma exacerbations, one aspect of asthma severity.
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- 2009
10. Facteurs environnementaux de l’asthme sévère et de l’allergie : résultats de l’étude EGEA
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Jean Bousquet, Jean Maccario, D. Charpin, Francine Kauffmann, N. Le Moual, Christophe Pison, Valérie Siroux, Marie-Pierre Oryszczyn, Pierre Scheinmann, Raphaëlle Varraso, Susan M. Kennedy, Isabelle Pin, Estelle Rage, Daniel Vervloet, and F Gormand
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Pulmonary and Respiratory Medicine - Abstract
Resume Introduction L’etude EGEA (Etude epidemiologique des facteurs Genetiques et Environnementaux de l’Asthme, l’atopie et l’hyperreactivite bronchique), une etude cas-temoins et familiale regroupant 2 048 individus, a ete initiee afin de rechercher les facteurs environnementaux et genetiques de l’asthme. Nous presentons les resultats portant sur les aspects phenotypiques et environnementaux de l’asthme severe et de l’allergie obtenus depuis 2002 dans l’etude EGEA. Methodes et Resultats Les resultats etayent le role de facteurs hormonaux dans la severite de l’asthme et certains marqueurs allergiques associes a l’asthme. Un indice de masse corporelle eleve etait associe a la severite de l’asthme chez les femmes ayant eu des regles precoces. Des associations sont apparues entre des marqueurs d’allergie (eosinophiles, IgE, atopie) et des evenements hormono-dependants chez les femmes (asthme premenstruel, menopause et contraceptifs oraux). Chez les asthmatiques, l’exposition professionnelle aux nuisances asthmogenes, le tabagisme actif et passif etaient associes a un score clinique de severite plus eleve. L’etude a mis en evidence le role protecteur de la vie a la campagne et de l’exposition aux animaux domestiques dans la petite enfance vis-a-vis de l’allergie chez l’adulte, etayant ainsi l’hypothese hygieniste. Conclusions De nouvelles hypotheses seront prochainement testees grâce a la seconde phase de l’etude actuellement en cours.
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- 2007
11. Facteurs génétiques et environnementaux de l’asthme et de l’allergie : synthèse des résultats de l’étude EGEA
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Valérie Siroux, C. Donnay, Bénédicte Jacquemin, Marta Rava, J. Bousquet, Patricia Margaritte-Jeannin, O Dumas, Rachel Nadif, Sofia Temam, Lidwien A.M. Smit, Emmanuelle Bouzigon, H. Aschard, Christophe Pison, Anne Boudier, F Gormand, Régis Matran, Florence Demenais, Chloé Sarnowski, F Kauffmann, Estelle Rage, J. Just, Mark Lathrop, N. Le Moual, Marie-Hélène Dizier, Isabelle Pin, Sébastien Chanoine, Raphaëlle Varraso, L. Vignoud, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Centre Hospitalier Universitaire [Grenoble] (CHU), Laboratoire d'épidémiologie des rayonnements ionisants (LEPID), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
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Pulmonary and Respiratory Medicine ,Allergie ,Allergy ,Hétérogénéité ,[SDV]Life Sciences [q-bio] ,Genetics ,Asthme ,Heterogeneity ,Environment ,Asthma ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,3. Good health ,Environnement - Abstract
Resume Introduction et methode L’etude francaise EGEA (etude epidemiologique des facteurs genetiques et environnementaux de l’asthme, l’hyperactivite bronchique et l’atopie) combine une etude cas-temoins et une etude familiale de cas (n = 2120) avec trois enquetes sur 20 ans. Cet article de synthese presente les travaux realises depuis 2007 (42 articles) sur la caracterisation phenotypique et l’etude de facteurs environnementaux et genetiques de l’asthme et des phenotypes associes. Resultats Les resultats epidemiologiques et genetiques confirment le caractere heterogene de l’asthme. L’âge de debut, le statut allergique et le niveau d’activite de la maladie jouent un role preponderant dans l’identification des differents phenotypes et des facteurs genetiques sous-jacents. Le role nefaste du tabagisme, des expositions a la pollution atmospherique, aux asthmogenes professionnels et aux produits de nettoyage sur la prevalence et/ou l’activite de l’asthme est etaye. La prise en compte d’interactions gene–environnement a permis d’identifier de nouveaux facteurs genetiques de susceptibilite et de preciser leur mode d’action. Conclusion L’etude EGEA participe aux avancees de la recherche en pneumologie au niveau international. Les nouvelles donnees phenotypiques, environnementales et biologiques permettront de caracteriser l’evolution a long terme de l’asthme et les facteurs associes a cette evolution.
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- 2015
12. Job-task-exposure matrices to assess occupational exposure to disinfectants among U.S. nurses
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Carlos A. Camargo, Frank E. Speizer, Jan Paul Zock, N. Le Moual, Catherine Quinot, Orianne Dumas, Paul K. Henneberger, Aleta Wiley, and Raphaëlle Varraso
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Task (computing) ,business.industry ,Disinfectant ,Environmental health ,Medicine ,Occupational exposure ,Information bias ,business ,medicine.disease ,Asthma - Abstract
Occupational exposure to disinfectants is associated with work-related asthma, especially in healthcare workers. However, little is known about the specific products involved. In epidemiologic studies, assessment of exposure by job-exposure matrices (JEM) is less prone to differential misclassification bias than self-report. We designed JEM and job-task-exposure matrices (JTEM) to better evaluate disinfectant exposures using data from the Nurses9 Health Study II, a prospective study of U.S. female registered nurses. Disinfectant use was assessed by an occupational questionnaire in a random sample of 8,580 nurses (49-68 years) without asthma. A JEM was created based on the frequency (1-3, >4 days/week) of reported use of 8 disinfectants in 8 nursing jobs. Nurses reported weekly disinfection tasks to clean instruments (21%) and surfaces (54%). A JTEM combining job types and disinfection tasks was created to further reduce misclassification. Exposure was evaluated in 3 classes: no, medium, high. Alcohol (weekly use: 39%), bleach (22%) and sprays (19%) were the most frequently used; more nurses were classified exposed (medium/high) by JEM (84% for alcohol, bleach and sprays) and JTEM (75%, 64%, 59%, respectively). Agreement between JEM and JTEM were fair (kappa: 0.2 to 0.4). For Emergency Room and administration nursing jobs, JEM and JTEM estimates were similar; more variations were observed for other jobs. The JTEM may provide more accurate estimates than the JEM especially for nursing jobs with heterogeneous tasks, which will reduce exposure misclassification. These methods and others based on exposure intensity/frequency will be applied to study associations with asthma. Grant: R01 OH-10359.
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- 2015
13. [Genetic and environmental factors of asthma and allergy: Results of the EGEA study]
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E, Bouzigon, R, Nadif, N, Le Moual, M-H, Dizier, H, Aschard, A, Boudier, J, Bousquet, S, Chanoine, C, Donnay, O, Dumas, F, Gormand, B, Jacquemin, J, Just, P, Margaritte-Jeannin, R, Matran, C, Pison, E, Rage, M, Rava, C, Sarnowski, L A M, Smit, S, Temam, R, Varraso, L, Vignoud, M, Lathrop, I, Pin, F, Demenais, F, Kauffmann, and V, Siroux
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Adult ,Hypersensitivity, Immediate ,Male ,Adolescent ,Polymorphism, Single Nucleotide ,Genetic Heterogeneity ,Risk Factors ,Air Pollution ,Occupational Exposure ,Humans ,Genetic Predisposition to Disease ,Child ,Genetic Association Studies ,Aged ,Family Health ,Smoking ,Environmental Exposure ,Middle Aged ,Health Surveys ,Asthma ,Phenotype ,Case-Control Studies ,Gene-Environment Interaction ,Tobacco Smoke Pollution ,France ,Bronchial Hyperreactivity - Abstract
The EGEA study (epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), which combines a case-control and a family-based study of asthma case (n=2120 subjects) with three surveys over 20 years, aims to identify environmental and genetic factors associated with asthma and asthma-related phenotypes. We summarize the results of the phenotypic characterization and the investigation of environmental and genetic factors of asthma and asthma-related phenotypes obtained since 2007 in the EGEA study (42 articles).Both epidemiological and genetic results confirm the heterogeneity of asthma. These results strengthen the role of the age of disease onset, the allergic status and the level of disease activity in the identification of the different phenotypes of asthma. The deleterious role of active smoking, exposure to air pollution, occupational asthmogenic agents and cleaning products on the prevalence and/or activity of asthma has been confirmed. Accounting for gene-environment interactions allowed the identification of new genetic factors underlying asthma and asthma-related traits and better understanding of their mode of action.The EGEA study is contributing to the advances in respiratory research at the international level. The new phenotypic, environmental and biological data available in EGEA study will help characterizing the long-term evolution of asthma and the factors associated to this evolution.
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- 2014
14. Relationships of active smoking to asthma and asthma severity in the EGEA study
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Valérie Siroux, Marie-Pierre Oryszczyn, Isabelle Pin, Francine Kauffmann, and N. Le Moual
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Pulmonary and Respiratory Medicine ,Genetics ,medicine.medical_specialty ,business.industry ,Odds ratio ,medicine.disease ,Confidence interval ,respiratory tract diseases ,Atopy ,immune system diseases ,Bronchial hyperresponsiveness ,Epidemiology ,medicine ,First-degree relatives ,Risk factor ,business ,Asthma - Abstract
The role of smoking as potential risk factor, selection factor ("healthy smoker" effect) and modifying factor (severity) of asthma was studied in the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA). The analysis involved 200 adult asthmatic cases recruited in chest clinics, 265 nonasthmatic controls and 586 relatives of asthmatics (147 with asthma). Asthma in childhood was not associated with a reduced take-up of smoking (odds ratio (OR)=1.06 in males and 0.98 in females), but smoker asthmatic cases quit more often than controls (OR = 2.20 (95% confidence interval (95% CI) 1.11-4.34) in males and 2.76 (1.19-6.42) in females). Adult onset asthma was unrelated to ever smoking (OR 1.07 in males and 1.02 in females). In asthmatic cases, active smoking was associated with asthma severity. Current smokers, compared to never and exsmokers, had more asthma symptoms, more frequent (> or =1 attack x day(-1)) asthma attacks (OR 2.39 (95% CI 1.06-5.36)) and higher asthma severity scores. No clear pattern regarding the relationships of smoking habits with asthma was observed in first degree relatives. It is concluded that active smoking is not a risk factor for asthma in adulthood, but that smoking increases asthma severity.
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- 2000
15. Asthme et changements de métier chez des infirmières
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Jan-Paul Zock, Paul K. Henneberger, N. Le Moual, Raphaëlle Varraso, Orianne Dumas, Carlos A. Camargo, Frank E. Speizer, and Aleta Wiley
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Pulmonary and Respiratory Medicine - Abstract
Introduction Un risque eleve d’asthme a ete observe chez les infirmieres et pourrait etre lie a l’exposition aux desinfectants. Nous avons etudie l’influence de l’asthme sur le type et les changements de metier chez les infirmieres chez 98 048 femmes participant a la Nurses’ Health Study II, une etude prospective americaine d’infirmieres suivies depuis 1989 (âge : 24-44 ans). Methodes Les informations sur les types de metier, l’asthme et la date de diagnostic etaient recueillies par questionnaires a l’inclusion en 1989 puis tous les 2 ans entre 1993 en 2011. Les associations entre l’asthme diagnostique avant l’inclusion et le type de metier et les changements de metiers entre 1989 et 2011, ont ete evaluees (regressions logistiques et modeles de Cox, ajustes sur l’âge et l’ethnicite). Resultats A l’inclusion, 44 % des femmes exercaient des metiers impliquant une exposition potentiellement elevee aux desinfectants (notamment bloc operatoire et urgences), et 12 % exercaient des metiers avec une probabilite faible d’exposition (formation/administration). Les femmes avec un asthme diagnostique avant l’inclusion ( n = 5311) etaient moins souvent employees en bloc operatoire ( odds ratio : 0,73 [IC 95 %, 0,63–0,86]) et aux urgences ou autres service exposes (0,89 [0,82–0,97]) qu’en formation/administration. Pendant le suivi, les femmes avec de l’asthme changeaient plus souvent de metier pour des metiers avec une faible probabilite d’exposition aux desinfectants ( hazard ratio : 1,13 [1,07–1,18]), en particulier celles avec un asthme plus severe (hazard ratio pour l’asthme leger persistant : 1,13, modere persistant : 1,26 ; severe persistant : 1,50, en comparaison avec l’asthme intermittent, p tendance : 0,004). Conclusion L’asthme etait associe au type de metier a l’inclusion et aux changements de metier chez les infirmieres. Cela pourrait en partie refleter l’evitement de tâches impliquant l’usage de desinfectants. Financements : R01 OH-10359 ; FRM SPE20130326585 ; FRSR.
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- 2015
16. Occupational exposures estimated by means of job exposure matrices in relation to lung function in the PAARC survey
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M. Avignon, N. Le Moual, E. Orlowski, Francine Kauffmann, Patrick Brochard, and Marc B. Schenker
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Adult ,Male ,Chemical fumes ,Job-exposure matrix ,Hazardous Substances ,Sex Factors ,Risk Factors ,Air Pollution ,Forced Expiratory Volume ,Occupational Exposure ,Environmental health ,Humans ,Medicine ,Royaume uni ,Lung function ,Exposure assessment ,business.industry ,Organic solvent ,Public Health, Environmental and Occupational Health ,Dust ,Middle Aged ,respiratory tract diseases ,Forced expiration ,Educational Status ,Female ,Gases ,Occupational exposure ,business ,Research Article - Abstract
OBJECTIVES--The aim of this analysis of the French Cooperative PAARC (Pollution Atmosphérique et Affections Respiratoires Chroniques) survey, was to test whether occupational exposures to dusts, gases, or chemical fumes or to specific hazards, estimated by job exposure matrices, were related to a decrease in forced expiratory volume in one second (FEV1). METHODS--The most recent occupation was recorded in adults, aged 25-59, from non-manual worker households. Analysis was restricted to 10,046 subjects whose occupation was encountered at least 10 times in the study and who performed good FEV1 tracings. From occupational title, exposures to dusts, gases, and chemical fumes, and to specific hazards were classified in three categories (no, low, and high) with a British, a French, and an Italian job exposure matrix. Specific hazards were analysed for the British and French job exposure matrices for the same 42 specific dusts, gases, and chemical fumes. To limit spurious associations, a selection of seven hazard groups and 12 specific hazards was set before the start of the analysis. Based on the consistency of the relations according to sex and the British and French job exposure matrices, associations of age, height, city, and smoking adjusted FEV1 score with occupational exposures were classified as very likely, possible, or unlikely. RESULTS--For the three job exposure matrices and both sexes clear exposure-response relations between the level of exposure to dusts, gases, and chemical fumes, and a decrease in FEV1 were found. Associations with FEV1 were classified as very likely for known hazards such as organic dusts and textile dusts, and not previously recognised hazards such as polycyclic aromatic hydrocarbons (PAHs) and detergents, and as possible for solvents, waxes and polishes, and diesel fumes. Associations found for PAHs and solvents were confirmed by the Italian job exposure matrix. Associations remained significant in women, but not in men, after adjustment for educational level. CONCLUSIONS--Hypotheses have been generated for exposure to detergents, PAHs, and solvents, but they need to be interpreted with caution before replication. Significant associations found for known risk factors with a decrease in FEV1 are arguments for the validity of the matrices. Despite the expected limitations of job exposure matrices, these results encourage further work to improve exposure assessment by job exposure matrices.
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- 1995
17. [Causal analysis approaches in epidemiology]
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O, Dumas, V, Siroux, N, Le Moual, and R, Varraso
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Causality ,Epidemiologic Studies ,Research Design ,Humans ,Models, Theoretical ,Algorithms - Abstract
Epidemiological research is mostly based on observational studies. Whether such studies can provide evidence of causation remains discussed. Several causal analysis methods have been developed in epidemiology. This paper aims at presenting an overview of these methods: graphical models, path analysis and its extensions, and models based on the counterfactual approach, with a special emphasis on marginal structural models. Graphical approaches have been developed to allow synthetic representations of supposed causal relationships in a given problem. They serve as qualitative support in the study of causal relationships. The sufficient-component cause model has been developed to deal with the issue of multicausality raised by the emergence of chronic multifactorial diseases. Directed acyclic graphs are mostly used as a visual tool to identify possible confounding sources in a study. Structural equations models, the main extension of path analysis, combine a system of equations and a path diagram, representing a set of possible causal relationships. They allow quantifying direct and indirect effects in a general model in which several relationships can be tested simultaneously. Dynamic path analysis further takes into account the role of time. The counterfactual approach defines causality by comparing the observed event and the counterfactual event (the event that would have been observed if, contrary to the fact, the subject had received a different exposure than the one he actually received). This theoretical approach has shown limits of traditional methods to address some causality questions. In particular, in longitudinal studies, when there is time-varying confounding, classical methods (regressions) may be biased. Marginal structural models have been developed to address this issue. In conclusion, "causal models", though they were developed partly independently, are based on equivalent logical foundations. A crucial step in the application of these models is the formulation of causal hypotheses, which will be a basis for all methodological choices. Beyond this step, statistical analysis tools recently developed offer new possibilities to delineate complex relationships, in particular in life course epidemiology.
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- 2012
18. Under-estimation of self-reported occupational exposure by questionnaire in hospital workers
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Isabelle Pin, M.-A. Denis, N. Massin, F Kauffmann, C. Donnay, Dominique Choudat, Orianne Dumas, J. Fevotte, R. Magis, N. Le Moual, Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Médecine et Santé au Travail, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Groupement Hospitalier Est, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Service Central de Médecine du Travail (SCMT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital de l'Hotel Dieu, Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Merck Sharp & Dohme (MSD), Hospital program of clinical research (PHRC)-Paris, National Research Agency - Health environment, health-work program, French Agency of health safety, environment and work (AFSSET, EST-09-15)., CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Hospices Civils de Lyon ( HCL ) -Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon ( HCL ) -Groupement Hospitalier Est, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement ( UMRESTTE UMR T9405 ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux ( IFSTTAR ), Service Central de Médecine du Travail ( SCMT ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital de l'Hotel Dieu, Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) ( INRS ( Vandoeuvre lès Nancy) ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut d'oncologie/développement Albert Bonniot de Grenoble ( INSERM U823 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), and Nadif, Rachel
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exposure assessment ,MESH: Asthma ,MESH : Aged ,MESH: Self Disclosure ,MESH: Occupational Exposure ,0302 clinical medicine ,Epidemiology ,MESH : Personnel, Hospital ,Medicine ,030212 general & internal medicine ,MESH : Environmental Monitoring ,MESH: Aged ,MESH: Middle Aged ,Age Factors ,[ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH : Occupational Diseases ,Middle Aged ,MESH : Adult ,030210 environmental & occupational health ,MESH: Case-Control Studies ,3. Good health ,Occupational Diseases ,MESH : Occupational Exposure ,MESH: Young Adult ,Health education ,epidemiology ,MESH : Self Disclosure ,MESH: Environmental Monitoring ,Environmental Monitoring ,Adult ,MESH: Occupational Diseases ,medicine.medical_specialty ,MESH : Case-Control Studies ,Self Disclosure ,Detergents ,MESH : Young Adult ,MESH : Asthma ,MESH: Personnel, Hospital ,Occupational medicine ,03 medical and health sciences ,Young Adult ,McNemar's test ,Environmental health ,Occupational Exposure ,Humans ,MESH : Middle Aged ,Asthma ,Exposure assessment ,Aged ,Estimation ,MESH: Age Factors ,MESH: Humans ,business.industry ,Gold standard ,MESH : Humans ,MESH: Disinfectants ,Public Health, Environmental and Occupational Health ,MESH: Adult ,MESH : Detergents ,medicine.disease ,Personnel, Hospital ,MESH : Disinfectants ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Case-Control Studies ,Healthcare worker ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH : Age Factors ,business ,disinfectant ,Disinfectants ,MESH: Detergents - Abstract
International audience; OBJECTIVES: The aim of the study was to determine whether self-reported occupational exposure to cleaning/disinfecting agents in hospital workers is accurate, in comparison to expert assessment, taken to be the gold standard. METHODS: In the Epidemiological Study of the Genetics and Environment of Asthma (EGEA), participants were interviewed on occupation with a specific questionnaire for hospital workers regarding tasks and cleaning/disinfecting agents. Two estimates of exposure were available: self-report and expert assessment. The expert assessment involved a standardised procedure to estimate intensity, frequency and probability of exposure for each job. The present analysis focused on eight exposures: formaldehyde, glutaraldehyde, bleach/chlorine, alcohol, quaternary ammonium components, ammonia, sprays and latex gloves. Agreement and differences between self-reported and expert estimates were studied by kappa and phi coefficients and McNemar tests, respectively. RESULTS: In the survey of 1571 adults, 176 ever hospital workers (327 occupations) with both self-reported and expert exposure assessments were studied. An underestimation of self-reported exposure was observed especially for formaldehyde (26.5% vs 32.7%, p=0.01), ammonia (7.4% vs 18.8%, p
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- 2011
19. Interactive Effects ofNOS1andNOS3Genetic Variants and Asthma on FeNOLevel in the EGEA Study
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F Kauffmann, Jean Bousquet, Isabelle Pin, Pierre Scheinmann, N. Le Moual, Mekki Boussaha, M Bechet, Rachel Nadif, Emmanuelle Bouzigon, M Lathrop, and Florence Demenais
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Interactive effects ,business.industry ,Medicine ,business ,medicine.disease ,Clinical psychology ,Asthma - Published
- 2009
20. Smoking Initiation in Asthmatics and Impact of Smoking on Asthma Incidence in the EGEA Cohort
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Valérie Siroux, Rachel Nadif, Isabelle Pin, JN Massala Mouele, N. Le Moual, Christophe Pison, F Kauffmann, M Nguile Makao, Lucile Vignoud, and Anne Boudier
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medicine.medical_specialty ,education.field_of_study ,business.industry ,Proportional hazards model ,Confounding ,Population ,medicine.disease ,respiratory tract diseases ,Atopy ,Internal medicine ,Cohort ,Medicine ,First-degree relatives ,Risk factor ,business ,education ,Asthma - Abstract
The aims were to assess longitudinally 1) the role of asthma as a potential selection factor for smoking initiation and 2) the role of smoking as a potential risk factor for asthma incidence in relatives of asthmatics. The analyses were conducted in the EGEA study, a 12−year follow−up of asthmatic cases, their first degree relatives and controls (n=1848). The first question was addressed in 511 non smoker children at inclusion (258 asthmatics, 253 non asthmatics). The second question was addressed in 496 adult relatives of cases, non asthmatic at inclusion. Survival analyses (Cox model) were conducted with adjustment on confounders (age, sex, ETS, father educational level, centre for question 1, and sex, age, educational level, atopy, rhinitis for question 2) and stratification for age. Children with asthma at inclusion started smoking as often as non asthmatic children (45.4% vs 48.6% respectively, RR[IC 95%] = 1.0 [0.7;1.3]). Among adult relatives of cases, 37 had incident asthma at follow−up (7.5%). Both smoking at inclusion (non smoker n=242, ex−smoker n=124, smoker n=130) and a time dependant smoking variable were used (never (n=341), beginner (n=22), persistent (n=74), former (n=55)). Smoking at inclusion did not affect asthma incidence (RR for smokers and ex−smokers compared to non smokers were 1.8 [0.8;3.9] and 0.7 [0.3;2.1] respectively). However, compared to never smokers, the risk for asthma incidence was increased in beginner and persistent smokers (RR=3.2 [1.0;10.1] and 2.5 [1.0;5.9]). Asthmatics started smoking as often as non asthmatics. This analysis indicates that smoking may be a risk factor for asthma incidence in first degree relatives of asthmatics, a potentially more sensitive population.
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- 2009
21. [Environmental factors for asthma severity and allergy: results from the EGEA study]
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V, Siroux, M P, Oryszczyn, R, Varraso, N, Le Moual, J, Bousquet, D, Charpin, F, Gormand, S, Kennedy, J, Maccario, C, Pison, E, Rage, P, Scheinmann, D, Vervloet, I, Pin, and F, Kauffmann
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Adult ,Hypersensitivity, Immediate ,Male ,Menarche ,Smoking ,Age Factors ,Environment ,Immunoglobulin E ,Asthma ,Body Mass Index ,Eosinophils ,Premenstrual Syndrome ,Epidemiologic Studies ,Phenotype ,Risk Factors ,Case-Control Studies ,Hypersensitivity ,Humans ,Female ,France ,Bronchial Hyperreactivity ,Menopause ,Child ,Biomarkers ,Contraceptives, Oral - Abstract
EGEA (Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), a case control and family study including 2048 individuals, was initiated to look for environmental and genetic risk factors for asthma. A synthesis of the results obtained since 2002 on phenotypic and environmental aspects of asthma severity and allergy are presented in this article.The results support a role for hormonal factors in asthma severity and in various allergic markers of asthma. A greater body mass index was related to a more severe asthma in women with early menarche. Associations between markers of allergy (eosinophils, IgE and atopy) and hormonal dependent events in women (premenstrual asthma, menopause and oral contraceptive use) have been found. In asthmatics, exposure to agents known to be associated with occupational asthma, active and passive smoking were associated with an increased clinical asthma severity score. The study underlines the protective role of country living and exposure to pets in early life on allergy markers in adulthood, supporting the hygiene hypothesis.New hypothesis will be tested in the near future from the second stage of this survey.
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- 2007
22. Twenty five year mortality and air pollution: results from the French PAARC survey
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N. Le Moual, D. Charpin, I. Annesi-Maesano, Christophe Declercq, Isabelle Baldi, L. Filleul, Daniel Vervloet, Christophe Paris, Stéphanie Vandentorren, Françoise Neukirch, Anne Cantagrel, J-F Tessier, F Kauffmann, Patrick Brochard, Virginie Rondeau, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Centre Régional de la Recherche Agronomique de Kénitra (CRRAK), Inram, Bousquet J, Annesi-Maesano I, F Carat, Léger D, M Rugina, C Pribil, El Hasnaoui A, je Chanal ., Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire santé, travail et environnement, Université Bordeaux Segalen - Bordeaux 2, Equipe de Biostatistique, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, Epidémiologie et Biostatistique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Nord [CHU - APHM], Observatoire Régional de la Santé Nord Pas-de-Calais, ORS Pas-De-Calais, Mécanismes physiopathologiques de l'insuffisance respiratoire et des complications de l'anesthésie, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de santé au travail et pathologie professionnelle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Rondeau, Virginie
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Male ,Lung Neoplasms ,Urban Population ,MESH: Asthma ,Air pollution ,010501 environmental sciences ,medicine.disease_cause ,MESH: Epidemiologic Methods ,01 natural sciences ,Body Mass Index ,MESH: Cause of Death ,chemistry.chemical_compound ,0302 clinical medicine ,Environmental protection ,Cause of Death ,11. Sustainability ,Epidemiology ,MESH: Animals ,030212 general & internal medicine ,MESH: Conjunctivitis, Allergic ,Vehicle Emissions ,2. Zero hunger ,MESH: Middle Aged ,MESH: Rhinitis ,Smoking ,MESH: Sex Distribution ,MESH: Immunoglobulin E ,Environmental exposure ,3. Good health ,MESH: Urban Population ,MESH: Vehicle Emissions ,Cardiovascular Diseases ,Epidemiological Monitoring ,Female ,France ,MESH: Environmental Monitoring ,Environmental Monitoring ,Adult ,medicine.medical_specialty ,MESH: Air Pollution ,MESH: Smoking ,MESH: Allergens ,MESH: Environmental Exposure ,MESH: Mites ,Black smoke ,MESH: Body Mass Index ,03 medical and health sciences ,Age Distribution ,MESH: Cross-Sectional Studies ,MESH: Skin Tests ,Air Pollution ,Environmental health ,medicine ,Humans ,Nitrogen dioxide ,Mortality ,Sex Distribution ,MESH: Age Distribution ,0105 earth and related environmental sciences ,MESH: Adolescent ,MESH: Humans ,MESH: Rhinitis, Allergic, Perennial ,MESH: Mortality ,Proportional hazards model ,business.industry ,Public Health, Environmental and Occupational Health ,MESH: Cardiovascular Diseases ,MESH: Adult ,MESH: Rhinitis, Allergic, Seasonal ,Environmental Exposure ,MESH: Male ,MESH: Lung Neoplasms ,MESH: France ,chemistry ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,13. Climate action ,Relative risk ,MESH: Pollen ,Commentary ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Epidemiologic Methods ,business ,Body mass index ,MESH: Female - Abstract
International audience; AIMS AND METHODS: Long term effects of air pollution on mortality were studied in 14,284 adults who resided in 24 areas from seven French cities when enrolled in the PAARC survey (air pollution and chronic respiratory diseases) in 1974. Daily measurements of sulphur dioxide, total suspended particles, black smoke, nitrogen dioxide, and nitric oxide were made in 24 areas for three years (1974-76). Cox proportional hazards models controlling for individual confounders (smoking, educational level, body mass index, occupational exposure) were applied, and frailty models used to take into account spatial correlation. Indicators of air pollution were the mean concentration. RESULTS: Models were run before and after exclusion of six area monitors influenced by local traffic (NO/NO2 >3 in ppb). After exclusion of these areas, analyses showed that adjusted risk ratios (95% CI) for TSP, BS, NO2, and NO for non-accidental mortality were 1.05 (1.02 to 1.08), 1.07 (1.03 to 1.10), 1.14 (1.03 to 1.25), and 1.11 (1.05 to 1.17) for 10 microg/m3 respectively. Consistent patterns for lung cancer and cardiopulmonary causes were observed. CONCLUSIONS: Urban air pollution assessed in the 1970s was associated with increased mortality over 25 years in France.
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- 2005
23. Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma
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J Hochez, Arnaud Lemainque, M H Dizier, Isabelle Pin, M Lathrop, Isabella Annesi-Maesano, Evelyne Paty, Marie-Pierre Oryszczyn, Florence Demenais, D. Charpin, N. Le Moual, Jean Bousquet, C Betard, Daniel Vervloet, Francine Kauffmann, F Gormand, R. Matran, M Guilloud-Bataille, Françoise Neukirch, Jocelyne Just, Emmanuelle Bouzigon, Génétique épidémiologique et structures des populations humaines (Inserm U535), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Immunopathologie de l'Inflammation, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie-Allergologie [Hôpital de la Timone - APHM], Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Service de pneumologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Modélisation mathématique et statistique en biologie et médecine, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Epidémiologie et Biostatistique, Hôpital Albert Calmette, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Mécanismes physiopathologiques de l'insuffisance respiratoire et des complications de l'anesthésie, Service de Pneumologie et d'Allergologie Pédiatriques, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de médecine aiguë spécialisée, CHU Grenoble-Hôpital Michallon, Groupe de Recherche en Informatique, Image et Instrumentation de Caen (GREYC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), MH Dizier, E Bouzigon, Hochez J, J Juste, Moual N Le, Lemainque A, R Matran, Neukirch F, MP Oryszczyn, E Paty, Pin I, Vervloet D, Lathrop M, Kauffmann F, F Demenais, Guilloud-Bataille M, Annesi-Maesano je, C Betard, Bousquet J, Charpin D, F Gormand, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
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Genetic Markers ,MESH: Asthma ,Genetic Linkage ,Maximum likelihood ,Asthma phenotypes ,Immunology ,MESH: Genetic Linkage ,Biology ,MESH: Genetic Markers ,MESH: Chromosomes, Human ,MESH: Phenotype ,Genome ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,medicine ,Chromosomes, Human ,Humans ,Genetic Predisposition to Disease ,Genetic Testing ,Genetics (clinical) ,MESH: Genome, Human ,Rhinitis ,030304 developmental biology ,Asthma ,Linkage (software) ,0303 health sciences ,MESH: Humans ,MESH: Genetic Testing ,Genome, Human ,MESH: Rhinitis ,MESH: Genetic Predisposition to Disease ,medicine.disease ,Phenotype ,3. Good health ,MESH: France ,030228 respiratory system ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,France - Abstract
International audience; In the sample of 295 French EGEA families with at least one asthmatic subject, a genome screen was conducted to identify potential linkage regions specific either to allergic rhinitis (AR) or to asthma as well as those shared by the two diseases. Two binary rhinitis phenotypes based on (1) diagnosis (ARbin1) and (2) symptoms (ARbin2) and a categorical ordered trait (ARcat) were considered. Asthma phenotype was based on answers to a standardized questionnaire plus the presence of bronchial hyper-responsiveness. Linkage analyses were conducted using the maximum likelihood binomial (MLB) method. These analyses provided potential evidence for linkage to three regions in the whole sample: 1p31 for the phenotype defined by ARbin2 plus asthma (P=0.00016), 2q32 for ARbin2 (P=0.00016) and 3p24-p14 for ARcat (P=0.001). Two other regions were detected in the subset of 185 families with at most one asthmatic sib: 9p22 and 9q22-q34 for ARbin1 (P=0.001 and 0.0007, respectively). No region showed evidence for linkage to asthma without being also linked to AR. While 1p31 may contain a genetic determinant common to asthma and AR, 2q32, 3p24-p14, 9p22 and 9q22-q34 are more likely to harbor genetic factors specific to AR.
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- 2005
24. Asthme et changements de métier chez des infirmières
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Jan-Paul Zock, Raphaëlle Varraso, Aleta Wiley, N. Le Moual, Carlos A. Camargo, Paul K. Henneberger, Frank E. Speizer, and Orianne Dumas
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Introduction Un risque eleve d’asthme a ete observe chez les infirmieres et pourrait etre lie a l’exposition aux desinfectants. Nous avons etudie l’influence de l’asthme sur le type et les changements de metier chez les infirmieres chez 114 778 femmes participant a la « Nurses’ Health Study II », une etude prospective americaine d’infirmieres suivies depuis 1989 (âge : 24–44 ans). Methodes Les informations sur les types de metier, l’asthme et la date de diagnostic etaient recueillies par questionnaires a l’inclusion en 1989 puis tous les deux ans entre 1993 en 2011. Les associations entre l’asthme diagnostique avant l’inclusion et le type de metier et les changements de metiers entre 1989 et 2011, ont ete evaluees (regressions logistiques et modeles de Cox, ajustes sur l’âge et l’ethnicite). Resultats A l’inclusion, 44 % des femmes exercaient des metiers impliquant une exposition potentiellement elevee aux desinfectants (notamment bloc operatoire et urgences), et 12 % exercaient des metiers avec une probabilite faible d’exposition (formation/administration). Les femmes avec un asthme diagnostique avant l’inclusion ( n = 5739 ; 5 %) etaient moins souvent employees en bloc operatoire ( odds ratio : 0,71–2 [IC95 %, 0,61–0,82]) et aux urgences ou autres service exposes (0,88 [0,81–0,96]) qu’en formation/administration. Pendant le suivi, les femmes avec de l’asthme changeaient plus souvent de metier pour des metiers avec une faible probabilite d’exposition aux desinfectants ( hazard ratio : 1,14 [1,09–1,20]). Conclusion L’asthme etait associe au type de metier a l’inclusion et aux changements de metier chez les infirmieres. Cela pourrait en partie refleter l’evitement de tâches impliquant l’usage de desinfectants.
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- 2014
25. Performance of population specific job exposure matrices (JEMs): European collaborative analyses on occupational risk factors for chronic obstructive pulmonary disease with job exposure matrices (ECOJEM)
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B. Rijcken, F Kauffmann, N. Le Moual, Dick Heederik, Susan M. Kennedy, E. Orlowski, Hans Kromhout, Per Bakke, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Thoracic Medicine [Bergen], Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Environmental and Occupational Health Group, Wageningen University and Research [Wageningen] (WUR), Ocupational Hygiene Program, University of British Columbia (UBC), Department Epidemiology, University of Groningen [Groningen], and Faraldo, Beatrice
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Male ,Gerontology ,LUNG-DISEASE ,PAARC ,MESH: Occupational Exposure ,0302 clinical medicine ,Risk Factors ,MESH: Risk Factors ,Forced Expiratory Volume ,Population specific ,030212 general & internal medicine ,Netherlands ,GENERAL-POPULATION ,education.field_of_study ,MESH: Middle Aged ,medicine.diagnostic_test ,Norway ,ZUTPHEN ,Middle Aged ,030210 environmental & occupational health ,MESH: Reproducibility of Results ,Data Interpretation, Statistical ,Papers ,language ,Female ,France ,Adult ,Spirometry ,medicine.medical_specialty ,Population ,Job-exposure matrix ,Norwegian ,MESH: Forced Expiratory Volume ,MESH: Norway ,03 medical and health sciences ,MESH: Lung Diseases, Obstructive ,medicine ,Humans ,Lung Diseases, Obstructive ,Risk factor ,education ,Exposure assessment ,MESH: Humans ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,MESH: Adult ,lung function ,occupational exposure ,job exposure matrix ,MESH: Male ,language.human_language ,MESH: France ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Netherlands ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Data Interpretation, Statistical ,MESH: Female ,Demography - Abstract
OBJECTIVES—To compare the performance of population specific job exposure matrices (JEMs) and self reported occupational exposure with data on exposure and lung function from three European general populations. METHODS—Self reported occupational exposure (yes or no) and present occupation were recorded in the three general population surveys conducted in France, The Netherlands, and Norway. Analysis was performed on subjects, aged 25-64, who provided good forced expiratory volume in 1 second (FEV1) tracings and whose occupations were performed by at least two people, in the French (6217 men and 5571 women), the Dutch (men from urban (854) and rural (780) areas), and the Norwegian (395 men) surveys. Two population specific JEMs, based on the percentage of subjects who reported themselves exposed in each job, were constructed for each survey and each sex. The first matrix classified jobs into three categories of exposure according to the proportion of subjects who reported themselves exposed in each job (P10-50 JEM, low
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- 2000
26. 77 Relevance of exposure to cleaning agents beyond cleaning professionals: Private homes and healthcare workers
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N. Le Moual, Dumas, Bédard, Zock, Kauffmann, and Varraso
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Selection bias ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Incidence (epidemiology) ,Public health ,Public Health, Environmental and Occupational Health ,Odds ratio ,medicine.disease ,Confidence interval ,Environmental health ,Health care ,Medicine ,business ,Body mass index ,Asthma ,media_common - Abstract
Workplace and home exposures to cleaning products constitute an emerging health issue. The aim is to address the potential adverse role of exposure to cleaning agents on asthma in private homes and healthcare workers. Regarding healthcare workers, recent publications showed that they may be exposed to high level of cleaning products. As a cause of concern, they underestimated their exposures and appeared as a high risk group for asthma. Regarding home cleaning, two studies have published on this topic and suggested a deleterious role of the frequent use of cleaning sprays on asthma activity and incidence. One of them suggested a possible avoidance of spray use by women with asthma. More recently, in a nested case-control survey on asthma of French women from the ‘Etude Epidemiologique aupres des femmes de la MGEN’ (E3N study), we investigated the association between self-reported weekly use of cleaning products (evaluated as previously) and current asthma among 570 women (235 with current asthma and 335 without asthma; 68 years, 59% never smokers). A positive association was suggested between weekly use of at least one spray and current asthma (odds ratio [95% confidence interval] adjusted for age, diploma, body mass index and smoking status: 1.45 [0.94–2.24], p = 0.09), with a significant association in women without cleaning help (1.86 [1.04–3.33]). Avoidance of polluted places was significantly more frequent in women with current asthma who had at least two symptoms. Domestic exposure to cleaning sprays may represent an important public health issue especially in women and it may be important to limit their use. Female hospital workers are exposed to numerous cleaning products at high risk for asthma. Selection bias may be important for both domestic and workplace exposures. More work is needed to identify the underlying mechanism (allergic or non-allergic) and to have accurate estimates of cleaning agents.
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- 2013
27. Cancer risk among workers in biomedical research
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C. Le Goaster, Denis Hémon, G. Michaud, N. Le Moual, M.-L. Mousel, G. Gachelin, L Mandereau, Fabrice Carrat, and Sylvaine Cordier
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Adult ,Male ,medicine.medical_specialty ,Internal medicine ,Neoplasms ,Surveys and Questionnaires ,Epidemiology ,medicine ,Humans ,Risk factor ,Bone cancer ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,Academies and Institutes ,Cancer ,Odds ratio ,Middle Aged ,medicine.disease ,Non-Hodgkin's lymphoma ,Surgery ,Occupational Diseases ,Standardized mortality ratio ,Cohort ,Female ,France ,business - Abstract
Objective This epidemiologic study was undertaken after a cluster of five cases of rare forms of cancer (bone sarcoma, non-Hodgkin's lymphoma) had been observed among biomedical research workers at the Pasteur Institute in Paris to ascertain whether their disease was connected with exposure during this research. Methods A mortality study included 3765 people who worked at the Pasteur Institute between 1971 and 1986 and were followed until the end of 1987. Within this cohort a nested case-referent study included 23 cases of cancer [non-Hodgkin's lymphoma (6), multiple myeloma (1), leukemia (3), pancreatic cancer (7), bone cancer (3), brain tumor (3)], and four referents per case, matched for gender and year of birth. Results Total mortality from cancer was less than expected, the standardized mortality ratio (SMR) being 72 for the men and 82 for the women. Among the women the proportion of pancreatic cancer cases was larger than expected [SMR 490, 95% confidence interval (95%CI) 158--1144], as was the number of brain cancer cases (SMR 239, 95% CI 48--696). Among the men, mortality from bone cancer was greater than expected (SMR 553, 95% CI 62--2006). In the nested case-referent study, more cases than referents had worked in the areas of molecular biology [odds ratio (OR) 7.1, 95% CI 1.5--33] and microbial genetics (OR 6.7, 95% CI 1.3--35). These cases especially included non-Hodgkin's lymphoma and bone cancer. Associated with this finding was the fact that more cases had used certain chemicals, including ethidium bromide, acrylamide, methylnitronitrosoguanidine and ethylmethanesulfonate, and radioactive compounds (essentially 32phosphorus). Conclusion As the products used are potent genotoxicants, the present findings suggest that work in biomedical research might well involve an increased risk of certain types of cancer; this conclusion should be balanced by the fact that two of the five index cases were included in the mortality study and four in the nested case-referent study.
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- 1995
28. O57 Aspects méthodologiques liés à l’estimation des typologies alimentaires en épidémiologie nutritionnelle
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Raphaëlle Varraso, Florent Monier, G. Miranda, N. Le Moual, Jean Maccario, Isabelle Romieu, Christophe Pison, J. Garcia-Aymerich, Francine Kauffmann, and De J. Battle
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,Medicine (miscellaneous) - Published
- 2011
29. Occupational risks of bladder cancer in France: a multicentre case-control study
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N. Le Moual, L Mandereau, Jean-Claude Limasset, Jacqueline Clavel, L. Boccon-Gibod, Denis Hémon, and Sylvaine Cordier
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Male ,medicine.medical_specialty ,Epidemiology ,Coal dust ,Logistic regression ,Occupational safety and health ,Occupational hygiene ,Risk Factors ,Environmental health ,Occupational Exposure ,Odds Ratio ,Medicine ,Humans ,Risk factor ,Aged ,Retrospective Studies ,business.industry ,Smoking ,General Medicine ,Odds ratio ,Middle Aged ,Coal Mining ,Confidence interval ,Surgery ,Occupational Diseases ,Urinary Bladder Neoplasms ,Case-Control Studies ,Chemical Industry ,Textile Industry ,Metallurgy ,Female ,France ,business - Abstract
The relationships between occupational risk factors in France and bladder cancer were assessed from a hospital-based case-control study conducted between 1984 and 1987 in five regions representing various industries, including mining, textile manufacture, metallurgy and the production of rubber and chemicals. The study concerned 765 cases (658 men and 107 women) and the same number of controls. Odds ratios (OR) adjusted for matching variables (age, place of residence and hospital), and tobacco smoking were estimated by unconditional logistic regression. A significantly increased risk of bladder cancer was observed among men employed in coal mining (OR = 2.42; 95% confidence interval (Cl) : 1.25-4.67) and the chemicals industry (OR = 2.36; 95% Cl : 1.23-4.53). Aircraft and ship's officers (OR = 11.8; 95% Cl : 1.46-95.7), managers (OR = 1.64; 95% Cl : 1.11-2.43) and street vendors (OR = 3.60; 95% Cl : 1.15-11.3) also had an increased risk. Among women, employment in the clothing industry was associated with a high OR (= 3.21; 95% Cl : 1.34-7.71). Assessment of individual exposures by a panel of industrial hygiene experts showed that significantly more cases than controls had been exposed to the following substances: chlorinated solvents (OR = 1.86; 95% Cl : 1.19-2.90), industrial oils and greases (OR = 1.44; 95% Cl : 1.10-1.89), welding fumes (OR = 1.40; 95% Cl : 0.98-2.01), coal dust (OR = 1.71; 95% Cl : 1.02-2.89) and metallic oxide dust (OR = 2.99; 95% Cl : 1.12-8.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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- 1993
30. Différences de déterminants de la toux selon le genre dans l’étude EGEA
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F Kauffmann, Valérie Siroux, Marie-Pierre Oryszczyn, N. Le Moual, Raphaëlle Varraso, C. Vuillard, and Isabelle Pin
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Pulmonary and Respiratory Medicine - Published
- 2006
31. Démarche qualité en épidémiologie - Projet pilote de certification ISO 9001 : 2000 dans l’étude EGEA- Collection biologique
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E. Mekong Adiogo, Francine Kauffmann, N. Le Moual, Isabelle Pin, Rachel Nadif, C. Ravault, Régis Matran, Marie-Pierre Oryszczyn, and Joane Ferran
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Pulmonary and Respiratory Medicine - Published
- 2006
32. Reply
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V. Siroux, I. Pin, M.P. Oryszczyn, N. Le Moual, and F. Kauffmann
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Pulmonary and Respiratory Medicine ,business.industry ,Anesthesia ,medicine ,Breathing ,Circadian rhythm ,medicine.symptom ,Nocturnal ,business ,Hypercapnia ,Hypoventilation - Published
- 2000
33. Combined Effect of Socioeconomic, Environmental, and Lifestyle Factors on Asthma: An Exposome Study in the French Nutrinet-Sante Cohort
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A. Guillien, A. Bédard, O. Dumas, J. Allegre, N. Arnault, A. Bochaton, N. Druesne-Pecollo, D. Dumay, L. Fezeu, S. Hercberg, N. Le Moual, H. Pilkington, S. Rican, G. Sit, F. Szabo, M. Touvier, P. Galan, T. Feuillet, R. Varraso, and V. Siroux
34. Body Mass Index and Exhaled Nitric Oxide in the French EGEA Study
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Pierre Scheinmann, Rachel Nadif, Christophe Pison, Jean Bousquet, Raphaëlle Varraso, K Joly, M Bechet, F Kauffmann, N. Le Moual, and Isabelle Pin
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Chromatography ,Chemistry ,Exhaled nitric oxide ,Body mass index
35. Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms
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Lemire, Pierre, Temam, Sofia, Quinot, Catherine, Sévin, Etienne, Remacle, Sophie, Supernant, Karine, Dumas, Orianne, Le Moual, Nicole, Eyriey, E., Licinia, A., Vellement, A., Pin, Isabelle, Hofmann, P., Hullo, Églantine, Llerena, Catherine, Morin, X., Morlot, A., Lepeule, Johanna, Lyon-Caen, Sarah, Philippat, Claire, Quentin, Joane, Siroux, Valérie, Slama, Rémy, Faraldo, Beatrice, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, MGEN Foundation for Public Health [Paris] (FESP-MGEN), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), EpiConcept [Paris], The Sepages Study Group., Fondation d’entreprise MGEN pour la santé publique (FESP MGEN), Anses-PNR-EST-2015-1-022/Ademe-1594C0091, Anses-PNR-EST-2017-1-101/Ademe-1762C0021 Seventh Framework Programme, FP7: FP7/2007-206, N308333-HELIX European Research Council, ERC: N 311765-E-DOHaD Agence Nationale de la Recherche, ANR: 14-CE21-0007-01, 19-CE36-0003-01, ANR 18-CE36-005, ANR-12-PDOC-0029-01, ANR-15-IDEX, ANR-15-IDEX-02 Institut National de la Santé et de la Recherche Médicale, Inserm Fondation de France: CLI-MATHES—00081169 Commissariat Général à l'Investissement, CGI Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES: PNR-EST-2018-1-264 Agir pour les Maladies Chroniques, Acknowledgments: We acknowledge the role of SEPAGES cohort study group: E. Eyriey, A. Licinia, A. Vellement (Groupe Hospitalier Mutualiste, Grenoble), I. Pin, P. Hofmann, E. Hullo, C. Llerena (Grenoble University Hospital, La Tronche), X. Morin (Clinique des Cèdres, Echirolles), A. Morlot (Clinique Belledonne, Saint-Martin d’Hères), J. Lepeule, S. Lyon-Caen, C. Philippat, I. Pin, J. Quentin, V. Siroux, R. Slama (Inserm, CNRS, University Grenoble Alpes IAB research center). We thank A. Benlakhryfa, L. Borges, Y. Gioria, clinical research assistants, J. Giraud, M. Marceau, M.-P. Martin, nurses, E. Charvet, A. Putod, midwives, M. Graca, K. Gridel, C. Pelini, fieldworkers, K. Guichardet, A. Levanic, C. Martel, E. Quinteiro neuropsychologists, the sta↵ from Grenoble Center for Clinical Investigation (CIC): J.-L. Cracowski, C. Cracowski, E. Hodaj, D. Abry, N. Gonnet and A. Tournier. A warm thank you also to M. Althuser, S. Althuser, F. Camus-Chauvet, P. Dusonchet, S. Dusonchet, L. Emery, P. Fabbrizio, P. Ho↵mann, D. Marchal André, X. Morin, E. Opoix, L. Pacteau, P. Rivoire, A. Royannais, C. Tomasella, T. Tomasella, D. Tournadre, P. Viossat, E. Volpi, S. Rey, E. Warembourg and clinicians from Grenoble University Hospital for their support in the recruitment of the study volunteers. We also thank A. Buchet, S.F. Caraby, J.-N. Canonica, J. Dujourdil, E. Eyriey, P. Hofmann, M. Jeannin, A. Licina, X. Morin, A. Nicolas, and all midwives from the four maternity wards of Grenoble urban areas. We thank B. Chevolon, C. Cornes, A.S. Gauchez, D. Guergour, P. Faure, J. Arnaud for thyroid hormones assessment. We thank the team of L. Chaperod (EFS) for its implication on the immunological aspects of the project. We thank G. Uzu (IRD) and J.-L. Ja↵rezo (CNRS) for their implication on PM oxidative potential assessment. We thank F.-X. Leupert, O. Bonnet and L. Goirand for the access to the birth certificate database from the Conseil Général de l’Isère. Sépages biospecimens are stored at Grenoble University Hospital (CHU-GA) biobank (bb-0033-00069), we would like to thank the whole CRB team, led by P. Mossuz and P. Lorimier, and in particular the technicians for the huge work of biospecimens processing and pooling: W. Jayar and L. Than, as well as G. Schummer. The Internet platform for secured data collection was developed by Epiconcept Paris (E. Sevin, S. Ployart, A. Polaert). SEPAGES data are stored thanks to Inserm RE-CO-NAI platform funded by Commissariat Général à l’Investissement, with the implication of Sophie de Visme (Inserm DSI). Many thanks to M.A. Charles, RE-CO-NAI coordinator, for her support. Finally, and importantly, we would like to express our sincere thanks to participants of the SEPAGES study. The authors are grateful for the help received from Ines Taarit and Mathias Clément to update the cleaning products ingredients database., Funding: The cohort was supported by the European Research Council (consolidator grant N 311765-E-DOHaD, PI, R. Slama), by the European Community’s Seventh Framework Programme (FP7/2007-206, grant N308333-HELIX, PI, M. Vrijheid), by ANR, the French Research Agency (PAPER project ANR-12-PDOC-0029-01, PI, J. Lepeule, SHALCOH project, 14-CE21-0007-01, PI, R. Slama, GUMME project, PI, R. Slama, ETAPE ANR 18-CE36-005, PI, J. Lepeule, EDeN project 19-CE36-0003-01, SYMER project, ANR-15-IDEX-02, PI, U. Schlattner, Mobil’Air project, ANR-15-IDEX, PI, S. Mathy, supported by University Grenoble-3Alpes), by ANSES (CNAP and HYPAXE projects, PI C. Philippat, PENDORE project, PNR-EST-2018-1-264, PI, V. Siroux), by Plan Cancer (Canc’Air project, PI, P. Guénel), by Association de Recherche sur le Cancer (ARC, PI, P. Guénel), by AGIR pour les maladies chroniques (PI, R. Slama and PRENAPAR project, V. Siroux), and Fonds de Recherche pour la Santé Respiratoire (FRSR, PI, I. Pin) and by Fondation de France (CLI-MATHES—00081169, J. Lepeule). We acknowledge the support of ANSES, Inserm and AGIR pour les maladies chroniques, for SEPAGES feasibility study. The support of 'SCUSI 2017' Région Auvergne-Rhône-Alpes programme is also acknowledged. COBANET-Sepages project was support by Anses and Ademe (COBANET: Anses-PNR-EST-2015-1-022/Ademe-1594C0091, PI: N Le Moual, CRESPINET: Anses-PNR-EST-2017-1-101/Ademe-1762C0021, PI: N Le Moual). Pierre Lemire benefited from a PhD scholarship of the University of Paris-Sud/Paris-Saclay, France., The cohort was supported by the European Research Council (consolidator grant N 311765-E-DOHaD, PI, R. Slama), by the European Community?s Seventh Framework Programme (FP7/2007-206, grant N308333-HELIX, PI, M. Vrijheid), by ANR, the French Research Agency (PAPER project ANR-12-PDOC-0029-01, PI, J. Lepeule, and EDeN project 19-CE36-0003-01, SYMER project, ANR-15-IDEX-02, PI, U. Schlattner, Mobil?Air project, ANR-15-IDEX, PI, S. Mathy, supported by University Grenoble-3Alpes), by ANSES (CNAP and HYPAXE projects, PI C. Philippat, PENDORE project, PNR-EST-2018-1-264, PI, V. Siroux), by Plan Cancer (Canc?Air project, PI, P. Gu?nel), by Association de Recherche sur le Cancer (ARC, PI, P. Gu?nel), by AGIR pour les maladies chroniques (PI, R. Slama and PRENAPAR project, V. Siroux), and Fonds de Recherche pour la Sant? Respiratoire (FRSR, PI, I. Pin) and by Fondation de France (CLIMATHES?00081169, J. Lepeule). We acknowledge the support of ANSES, Inserm and AGIR pour les maladies chroniques, for SEPAGES feasibility study. The support of ?SCUSI 2017? R?gion Auvergne-Rh?ne-Alpes programme is also acknowledged. COBANET-Sepages project was support by Anses and Ademe (COBANET: Anses-PNR-EST-2015-1-022/Ademe-1594C0091, PI: N Le Moual
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medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,[SDV]Life Sciences [q-bio] ,lcsh:Medicine ,Smartphone application ,Logistic regression ,Article ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Environmental health ,Epidemiology ,Odds Ratio ,medicine ,Humans ,030212 general & internal medicine ,Association (psychology) ,smartphone application ,Asthma ,household cleaning products ,business.industry ,lcsh:R ,Public Health, Environmental and Occupational Health ,Asthma symptoms ,Odds ratio ,asthma ,medicine.disease ,3. Good health ,030228 respiratory system ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Smartphone ,business ,Kappa ,Disinfectants - Abstract
International audience; Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.
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- 2021
36. Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort
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Tajidine Tsiavia, Joseph Henny, Marcel Goldberg, Marie Zins, Nicolas Roche, Laurent Orsi, Rachel Nadif, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université Paris Cité - UFR Médecine [Santé] (UPCité UFR Médecine), Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), ANR-11-INBS-0002, AstraZeneca, Meso Scale Diagnostics, MSD, Fondation pour la Recherche Médicale, FRM: ECO202006011654, H. Lundbeck A/S, Conservatoire National des Arts et Métiers, CNAM, The CONSTANCES cohort receives grants from ANR (ANR-11-INBS-0002), the Caisse nationale d'assurance maladie-CNAM and the Ministry of research. CONSTANCES also receives funding from MSD, AstraZeneca, Lundbeck and L'Oréal, managed by INSERM-Transfert. T.Tsiavia is supported by a PhD grant from the Fondation pour le Recherche Médicale (ECO202006011654)., T.Tsiavia, L.Orsi and R.Nadif have verified the underlying data, designed and conducted the study, J.Henny, M.Goldberg, M.Zins, L.Orsi and R.Nadif contributed to the data acquisition, T.Tsiavia, L.Orsi and R.Nadif interpreted the data, T.Tsiavia, L.Orsi and R.Nadif drafted the article, T.Tsiavia, J.Henny, M.Goldberg, M.Zins, N.Roche, L.Orsi and R.Nadif contributed to the critical review of important intellectual content, all authors edited and approved the final manuscript. The authors thank the ?Caisse nationale d'assurance maladie? (CNAM) and the ?Centres d'examens de sant?? of the French Social Security which are collecting a large part of the data, as well as the ?Caisse nationale d'assurance vieillesse?, ClinSearch, Asqualab and Eurocell in charge of the data quality control. The authors thank all those who participated to the setting of the study and on the various aspects of the examinations involved: interviewers, technicians for lung function testing, coders, those involved in quality control, data and sample management and all the staffs from the inclusion centers (HPCs). They are indebted to all the participating individuals without whom the study would not have been possible. The authors also thank S Le Got, S Lemonnier, A Ozguler, C Ribet from Inserm UMS11. The authors are also grateful to Groupe Respiratoire CONSTANCES: MC Delmas, O Dumas, V Giraud, Y Iwatsubo, B Leynaert, N Le Moual, T Perez, R Varraso. The CONSTANCES cohort receives grants from ANR (ANR-11-INBS-0002), the Caisse nationale d'assurance maladie-CNAM and the Ministry of research. CONSTANCES also receives funding from MSD, AstraZeneca, Lundbeck and L'Or?al, managed by INSERM-Transfert. T.Tsiavia is supported by a PhD grant from the Fondation pour le Recherche M?dicale (ECO202006011654). Access to sensitive and personal data, such as those from CONSTANCES cohort, is restricted by French law. The CONSTANCES coordination team makes the data available, upon request, to qualified researchers who have obtained prior authorization from the French national data protection authority (Commission de l'informatique et des libert?s, CNIL). Information for applicants to CONSTANCES data is available on the website: https://www.constances.fr/CFP.pdf. CONSTANCES investigators may be contacted at following address: contact@constances.fr, and HAL UVSQ, Équipe
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Male ,Inflammation ,Medicine (General) ,Neutrophils ,Neutrophil ,General Medicine ,Eosinophil ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,General Biochemistry, Genetics and Molecular Biology ,Asthma ,Eosinophils ,Leukocyte Count ,Phenotype ,Blood ,R5-920 ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Humans ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Adults ,Medicine ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology - Abstract
International audience; Background: Asthma is an inflammatory heterogeneous disease. Asthma inflammatory phenotypes based on blood eosinophil and neutrophil counts have never been identified and characterized in population-based studies.Methods: Adults with current asthma and available blood eosinophil and neutrophil counts from the French population-based CONSTANCES cohort were included. Current asthma was defined by reports of asthma attacks, symptoms or treatments in the last 12 months. Inflammatory phenotypes were based on low (L) and high (H) blood (B) eosinophil (E) (LBE/HBE
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- 2022
37. Changes in household use of disinfectant and cleaning products during the first lockdown period in France.
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Pacheco Da Silva E, Varraso R, Orsi L, Wiernik E, Goldberg M, Paris C, Fezeu LK, Ribet C, Nadif R, Carrat F, Touvier M, Zins M, Dumas O, and Le Moual N
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- Humans, France epidemiology, Female, Male, Middle Aged, Quarantine, Adult, Detergents, Longitudinal Studies, Communicable Disease Control methods, Surveys and Questionnaires, Household Products, SARS-CoV-2, Household Work statistics & numerical data, Pandemics, COVID-19 epidemiology, COVID-19 prevention & control, Disinfectants
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Background: Few studies evaluated the use of Household Disinfectant and Cleaning Products (HDCPs) during the COVID-19 pandemic, but no population-based cohorts used longitudinal data. We studied changes in HDCPs during the first lockdown, based on longitudinal data from the French population-based NutriNet-Santé and CONSTANCES cohorts., Methods: Based on standardized questionnaires on household cleaning tasks in 2018-2019 and around the first lockdown in France (March17-May3 2020), we compared the duration of weekly use of HDCPs (< 1 day/week, < 10 min/week; 10-30 min/week; > 30 min/week) and the household cleaning help (yes/no) before and during the lockdown period by Bhapkar and McNemar's tests. Moreover, we assessed self-reported changes in the frequency of HDCPs during the lockdown from before (unchanged/increased)., Results: Analyses were carried on 31,105 participants of NutriNet-Santé (48 years, 75% women, 81% ≥ high school diploma) and 49,491 of CONSTANCES (47 years, 51% women, 87% ≥ high school diploma). During the lockdown, compared with 2018-2019, duration of HDCPs use increased (> 30 min; NutriNet-Santé: 44% versus 18%; CONSTANCES: 63% versus 16%) and household help decreased (NutriNet-Santé: 5% versus 40%; CONSTANCES: 3% versus 56%). Regarding the frequency of HDCPs use, 55% of participants of NutriNet-Santé (57% women/49% men) and 83% of CONSTANCES (86% women/81% men) reported an increased use since the beginning of the lockdown, significantly higher among women (p < 0.0001)., Conclusions: The frequency and duration of weekly use of HDCPs has significantly increased since the pandemic. As the use of HDCPs is associated with health issues, further studies are now needed to evaluate the potential health impacts of these changes., (© 2024. The Author(s).)
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- 2024
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38. Correspondence: "The impact of indoor pollution on asthma-related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma".
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Dumas O and Le Moual N
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- Humans, Hypersensitivity etiology, Hypersensitivity epidemiology, Environmental Exposure adverse effects, Asthma etiology, Asthma epidemiology, Air Pollution, Indoor adverse effects
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- 2024
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39. Asthma control in severe asthma and occupational exposures to inhalable asthmagens.
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Walters GI, Reilly C, Le Moual N, Huntley CC, Hussein H, Marsh J, Bahron A, Krishna MT, and Mansur AH
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- Humans, Male, Adult, Cross-Sectional Studies, Female, Middle Aged, Young Adult, Adolescent, Detergents adverse effects, Severity of Illness Index, United Kingdom epidemiology, Allergens administration & dosage, Allergens adverse effects, Inhalation Exposure adverse effects, Occupational Exposure adverse effects, Asthma epidemiology, Asthma, Occupational epidemiology
- Abstract
Introduction: Work-related asthma accounts for ≥25% of asthma in working-age populations, though the relationship between work exposures and symptoms is frequently missed, leading to poor health and employment outcomes. We hypothesised that inhalable exposures at work are associated with poor asthma control in severe asthma (SA)., Methods: We searched the Birmingham (UK) Regional NHS SA Service clinical database (n=1453 records; 1 March 2004 to 1 March 2021) and undertook a cross-sectional study using baseline data collected at diagnosis. We included all employed patients aged 16-64 with documented current occupation (n=504), and collected socio-demographic, general health and asthma-specific data, including Asthma Control Questionnaire 7 (ACQ7) score. The Occupational Asthma Specific Job-Exposure Matrix (OAsJEM) was employed to determine the likelihood of exposure to respiratory sensitisers, irritants, cleaning agents and detergents; associations between exposures and ACQ7 were investigated using binary and multinomial regression., Results: Frequently reported occupations were care assistants (7%) and nurses (6%); 197/504 (39%) patients were exposed to an asthmagen, including respiratory sensitisers (30%), airway irritants (38%) and cleaning products/disinfectants (29%). ACQ7 score was available for 372/504 (74%) patients, of whom 14% had adequate control (ACQ7=0-1.5). After adjustment for major confounders there were no significant associations between inhaled asthmagens and ACQ7 score (either as binary or multinomial outcomes)., Conclusion: JEM-determined workplace exposures to inhaled asthmagens are not associated with asthma control in SA; 29-39% of patients may have current exposure to workplace asthmagens. Routine collection of lifetime occupational data including current job role and level of exposure, in the national asthma registry, would give further insights into this relationship., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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40. Development of a crosswalk to convert French PCS2003 into international ISCO88 occupational classifications. Application to the Occupational Asthma-specific Job-Exposure Matrix (OAsJEM).
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Pilorget C, Dananché B, Garras L, Orsi F, Sit G, Ribet C, Houot MT, Goldberg M, Dumas O, and Le Moual N
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- Humans, France, Occupations statistics & numerical data, Occupational Diseases, Asthma etiology, Risk Assessment methods, Occupational Exposure statistics & numerical data, Occupational Exposure analysis, Asthma, Occupational etiology
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Introduction: The problem of transcoding is recurrent when researchers wish to link occupational data from cohorts to Job-Exposure Matrices (JEMs) which were not set up in the same classifications. The Occupational Asthma-specific JEM (OAsJEM) is a JEM developed for assessing exposure to agents known at risk for asthma for jobs coded with ISCO88 occupation classification. To apply the OAsJEM in the CONSTANCES cohort, in which jobs and industries were coded with French PCS2003 and NAF2008 classifications respectively, we developed a crosswalk to convert jobs from PCS2003 into ISCO88 classification., Methods: This work was carried out by 2 skilled coders and 1 novice coder who have worked independently by using different tools and transcoding strategies defined a priori. Consensus meetings were organized with skilled coders to define the final crosswalk. This work was elaborated in 2 steps: (i) for 38 ISCO88 codes classified as potentially exposed to cleaning and disinfection products by the OAsJEM, and (ii) for all jobs from the ISCO88 classification. A comparison between the 3 initial coder's crosswalk proposals and the final crosswalk was made for the 38 ISCO codes in step (i)., Results: The final crosswalk provided 998 matches between the 482 4-digit PCS2003 codes, 308 4-digit ISCO88 codes, and 31 3-digit ISCO88 codes. Information regarding the NAF2008 industry classification was also used in some cases to improve the final crosswalk. For the selected 38 ISCO88 codes, the final crosswalk provided 110 combinations, but the number of proposed ISCO88-PCS2003 couples by each of the 3 coders varied greatly from 68 to 153. In addition, an important variability between the 3 coders were observed among the number of common combinations between the initial coder's proposals and the final crosswalk (from 47% to 78%)., Discussion: We have developed a crosswalk specifically for an application of the OAsJEM in population-based surveys using the PCS2003 occupation classification. The development of this crosswalk is of great interest for the use of OAsJEM on the data of the CONSTANCES cohort and on any other survey with occupational data coded according to the French classifications. This OAsJEM crosswalk could be used by other teams to evaluate occupational exposures known to be at risk of asthma from occupational calendars coded with French classifications., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Occupational Hygiene Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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41. Household Use of Irritant and Sprayed Cleaning Products and Asthma Endotypes. A Brief Report.
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Pacheco Da Silva E, Nadif R, Dohoukpe E, Orsi L, Quentin J, Varraso R, Siroux V, Dumas O, and Le Moual N
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- Humans, Female, Male, Adult, Household Products adverse effects, Middle Aged, Child, Adolescent, Asthma chemically induced, Detergents adverse effects, Irritants adverse effects
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Competing Interests: Conflict of interest: None declared.
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- 2024
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42. Airway Diseases Related to the Use of Cleaning Agents in Occupational Settings.
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Mwanga HH, Dumas O, Migueres N, Le Moual N, and Jeebhay MF
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- Humans, Asthma, Occupational diagnosis, Disinfectants adverse effects, Occupational Diseases diagnosis, Occupational Exposure adverse effects, Detergents adverse effects
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Exposure to disinfectants and cleaning products (DCPs) is now a well-established risk factor for work-related asthma (WRA). However, questions remain on the specific causal agents and pathophysiological mechanisms. Few studies have also reported an association between DCPs and rhinitis or chronic obstructive pulmonary disease. This review discusses the recent evidence pertaining to airway diseases attributable to occupational exposure to DCPs. In contrast to other agents, the incidence of WRA due to DCPs has increased over time. The use of DCPs in spray form has clearly been identified as an added risk factor. The mechanisms for WRA associated with DCPs remain poorly studied; however, both allergic and nonallergic responses have been described, with irritant mechanisms thought to play a major role. An early diagnostic workup based on clinical assessment accompanied by evaluation of lung function and immunological and airway inflammatory markers is important to guide optimal care and exposure avoidance to the implicated agent. Future research should focus on the effects of "green" products, pathophysiological mechanisms, and quantitative exposure assessment including the use of barcode-based methods to identify specific agents. There is an urgent need to strengthen preventive measures and interventions to reduce the burden of airway diseases associated with DCPs., (Copyright © 2024 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
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- 2024
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43. Biocide and other semi-volatile organic compound concentrations in settled indoor dust of CRESPI daycare centers and implication for public health.
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Mane MK, Raffy G, Glorennec P, Bonvallot N, Bonnet P, Dumas O, Nchama AE, Saramito G, Duguépéroux C, Mandin C, Le Moual N, and Le Bot B
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- Humans, Infant, Public Health, Environmental Monitoring, Child, Preschool, Dust analysis, Volatile Organic Compounds analysis, Child Day Care Centers, Air Pollution, Indoor analysis, Disinfectants analysis
- Abstract
This study investigates the presence of biocides and other semi-volatile organic compounds (SVOCs) in cleaning products used in daycare centers and health impact through ingestion of settled dust by young children. In Paris metropolitan area, 106 daycares area were investigated between 2019-2022. Fifteen substances were analyzed in settled indoor dust by gas chromatography-tandem mass spectrometry. Detection rates and concentrations ranged from 5 to 100%, and
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- 2024
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44. Household Use of Green Cleaning Products, Disinfecting Wipes, and Asthma Control Among Adults.
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Pacheco Da Silva E, Varraso R, Lenzotti AM, Fezeu LK, Sit G, Galan P, Hercberg S, Touvier M, Paris C, Dumas O, and Le Moual N
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- Adult, Humans, Female, Middle Aged, Male, Irritants, Cross-Sectional Studies, Anti-Infective Agents, Asthma epidemiology, Disinfectants, Occupational Exposure
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Background: The use of household disinfectants and cleaning products (HDCPs) may negatively impact asthma control, but studies remain scarce. Moreover, no study considered green products or wipes, increasingly used during home cleaning., Objective: To assess the associations between the use of HDCPs, including disinfecting wipes and green products, and asthma control based on data from the French Web-based NutriNet-Santé cohort., Methods: Using a standardized questionnaire (2018), we assessed asthma control (never asthma: reference; controlled: Asthma Control Test ≥ 20; uncontrolled: Asthma Control Test < 20) and the use of HDCPs, including 2 types of products (irritants and green products) and 2 application modes (sprays and disinfecting wipes). Cross-sectional associations of the frequency of weekly use of HDCPs at home with asthma control, adjusted for sex, age, smoking status, body mass index, and educational level were assessed by multinomial logistic regressions., Results: Analyses were performed on 37,043 adults (mean age 47 y; 75% women; 62% with a weekly use of at least 1 HDCP). Strong associations were observed between weekly use of HDCPs and uncontrolled asthma. In particular, an almost daily use (4-7 d/wk) of irritants (odds ratio [OR] 2.81; 95% confidence interval [95% CI] 1.97-4.00) and green products (OR 2.40; 95% CI 1.70-3.39) as well as sprays (OR 2.69; 95% CI 1.97-3.68) and disinfecting wipes (OR 3.51; 95% CI 2.31-5.33) was associated with uncontrolled asthma. When not co-used with irritants and sprays, associations remained statistically significant for both disinfecting wipes and green products., Conclusions: Weekly use of HDCPs, including green products or wipes, was associated with uncontrolled asthma and should be considered by health practitioners in order to improve asthma control., (Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
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- 2024
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45. Chronic occupational exposures to irritants and asthma in the CONSTANCES cohort.
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Sit G, Orsi L, Iwatsubo Y, Dananché B, Orsi F, Goldberg M, Leynaert B, Nadif R, Ribet C, Roche N, Roquelaure Y, Varraso R, Zins M, Pilorget C, Le Moual N, and Dumas O
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- Adult, Male, Humans, Female, Irritants adverse effects, Cross-Sectional Studies, Solvents adverse effects, Occupational Diseases chemically induced, Occupational Diseases epidemiology, Occupational Exposure adverse effects, Asthma, Occupational chemically induced, Asthma, Occupational epidemiology
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Objectives: The impact of chronic occupational exposures to irritants on asthma remains discussed. We studied the associations between occupational exposures and asthma, with specific interest for chronic exposure to irritants, including disinfectants and cleaning products (DCPs) and solvents., Methods: Cross-sectional analyses included 115 540 adults (55% women, mean age 43 years, 10% current asthma) working at inclusion in the French population-based CONSTANCES cohort (2012-2020). Current asthma was defined by ever asthma with symptoms, medication or asthma attacks (past 12 months), and the asthma symptom score by the sum of 5 respiratory symptoms (past 12 months). Both lifetime and current occupational exposures were assessed by the Occupational Asthma-specific Job-Exposure Matrix. Associations were evaluated by gender using logistic and binomial negative regressions adjusted for age, smoking status and body mass index., Results: In women, associations were observed between current asthma and lifetime exposure to irritants (OR 1.05, 95% CI 1.00 to 1.11), DCPs (1.06, 95% CI 1.00 to 1.12) and solvents (1.06, 95% CI 0.98 to 1.14). In men, only lifetime exposure to DCPs (1.10, 95% CI 1.01 to 1.20) was associated with current asthma. Lifetime exposure to irritants was associated with higher asthma symptom score both in women (mean score ratio: 1.08, 95% CI 1.05 to 1.11) and men (1.11, 95% CI 1.07 to 1.15), especially for DCPs (women: 1.09, 95% CI 1.06 to 1.13, men: 1.21, 95% CI 1.15 to 1.27) and solvents (women 1.14, 95% CI 1.10 to 1.19, men: 1.10, 95% CI 1.05 to 1.15). For current exposures, no consistent associations were observed with current asthma and asthma symptom score., Conclusions: Lifetime occupational exposures to irritants were associated with current asthma and higher asthma symptom score. These exposures should be carefully considered in asthma management., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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46. Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults.
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Guillien A, Niespodziana K, Mauclin M, Boudier A, Varraso R, Leynaert B, Dumas O, Le Moual N, Schlederer T, Bajic M, Borochova K, Errhalt P, Vernet R, Nadif R, Bousquet J, Bouzigon E, Valenta R, and Siroux V
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- Male, Child, Adult, Humans, Female, Adolescent, Middle Aged, Rhinovirus, Immunoglobulin G, Antibodies, Viral, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus, Human, Viruses, Enterovirus Infections
- Abstract
Introduction: Exposure to respiratory viruses is a significant cause of morbidity and affects virus-specific antibody levels. Little is known about determinants associated with immune response to these viruses. We aimed to investigate the determinants of respiratory syncytial virus (RSV)- and rhinovirus (RV)- specific IgG responses in both children and adults., Methods: The study is based on the EGEA cohort, composed of 530 samples of children in EGEA1 (1991-95) and 1241 samples of adults in EGEA2 (2003-07). Cumulative RV-specific IgG levels (species A, B and C) and IgG levels to RSV-G protein were measured by using micro-array technoloy. Multiple linear mixed models (random effect to account for familial dependence) were performed to assess associations between age, sex, body mass index (BMI), tobacco smoke exposure and season of blood sampling with RSV-and RV-specific IgG levels., Results: In children (11.1 ± 2.8 years old, 57% boys), higher RV-specific IgG levels were associated with older age (only for RV-B), female sex and lower BMI, while only older age was associated with higher RSV-specific IgG levels. In adults (43.5 ± 16.7 years old, 48% men), younger age, female sex, lower BMI, active smoking and all seasons except summer were associated with higher RV-specific IgG levels. Older age, active smoking and all seasons except summer were associated with higher RSV-specific IgG levels., Conclusion: Personal and seasonal determinants of RSV- and RV-specific IgG levels seem to vary according to the respiratory virus type and between children and adults, suggesting different patterns of responses along the life course., Competing Interests: Author RuV has received research grants from Worg Pharmaceuticals, Hangzhou, China, HVD Biotech, Vienna, Austria; and Viravaxx, Vienna, Austria. He serves as a consultant for Viravaxx and Worg. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Guillien, Niespodziana, Mauclin, Boudier, Varraso, Leynaert, Dumas, Le Moual, Schlederer, Bajic, Borochova, Errhalt, Vernet, Nadif, Bousquet, Bouzigon, Valenta and Siroux.)
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- 2024
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47. Reply to "Both quality of life and exacerbation are important outcomes of work-related asthma".
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Suarthana E, Le Moual N, Henneberger PK, Kigloo HN, and Vandenplas O
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- Humans, Surveys and Questionnaires, Quality of Life, Asthma
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- 2024
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48. Work-Related Asthma and Its Impact on Quality of Life and Work Productivity.
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Suarthana E, Le Moual N, Lemière C, Bousquet J, Pierre S, Sousa-Pinto B, Afadiyanti Parfi A, Van Brussel P, Nassiri Kigloo H, Vandenplas O, and Henneberger PK
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- Humans, Quality of Life, Cross-Sectional Studies, Occupational Diseases, Asthma diagnosis, Rhinitis complications, Asthma, Occupational epidemiology
- Abstract
Background: The impact of work-related asthma (WRA) on quality of life (QoL) and work productivity remains largely neglected/uncertain despite its high prevalence., Objective: To investigate the association of WRA with QoL and work productivity as compared with subjects with non-WRA and those without asthma and rhinitis., Methods: A cross-sectional survey was carried out among workers during their periodic occupational health visit in Belgium. The Mini Asthma Quality of Life Questionnaire, the 8-item Medical Outcome Study Short Form instrument, and the Work Productivity and Activity Impairment-General Health questionnaire were administered. Survey participants were divided into 3 groups: (1) WRA (current asthma with ≥2 respiratory symptoms at work; n = 89); (2) non-WRA (current asthma without work-related respiratory symptoms; n = 119); and (3) the reference group (no asthma and no lower respiratory, nasal, or eye symptoms; n = 815). Associations of QoL and work productivity with WRA were evaluated by multivariable regression analyses., Results: WRA and having poor asthma control were significantly associated with lower global Mini Asthma Quality of Life Questionnaire scores compared with non-WRA. Asthmatic subjects had significantly lower physical and mental health component scores of the 8-item Medical Outcome Study Short Form instrument and overall work productivity compared with the reference group, with greater impairment in workers with WRA than in those without WRA. Moreover, workers with WRA had higher percentages of doctor visits and income reduction because of respiratory symptoms than those with non-WRA. Work-related rhinitis and depression were associated with reduced QoL, independent of the effect of WRA., Conclusions: WRA should be managed comprehensively to reduce the worsening of QoL and work productivity of those affected., (Copyright © 2023 American Academy of Allergy, Asthma & Immunology. All rights reserved.)
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- 2024
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49. Exploration of associations between occupational exposures and current adult eczema.
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Lopez DJ, Alif S, Dharmage S, Lodge CJ, Bui DS, Le Moual N, Waidyatillake NT, Su JC, Abramson M, Walters EH, Hamilton GS, Bowatte G, Erbas B, Benke G, Perret J, and Lowe AJ
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- Middle Aged, Animals, Humans, Adult, Allergens, Prevalence, Acrylates, Risk Factors, Dermatitis, Atopic complications, Eczema epidemiology, Eczema etiology, Occupational Exposure adverse effects, Asthma, Occupational epidemiology, Asthma, Occupational etiology
- Abstract
Objectives: There is a scarcity of evidence on occupational exposures that may increase eczema in adults. We aimed to investigate potential associations between occupational exposures and eczema in middle-aged adults., Methods: A lifetime work history calendar was collected from the Tasmanian Longitudinal Health Study participants when they were at age 53. Their work history was collated with the occupational asthma-specific job exposure matrix to define ever-exposure and cumulative exposure unit-years since no eczema job exposure matrix is available. Eczema was determined using the report of flexural rash that was coming and going for at least 6 months in the last 12 months. Skin prick tests were used to further subgroup eczema and atopic eczema (AE) or non-AE (NAE). Logistic and multinomial regression models were used to investigate the associations., Results: Eczema prevalence was 9.1%. Current occupational exposure to animals (adjusted OR, aOR=3.06 (95% CI 1.43 to 6.58)), storage mites (aOR=2.96 (95% CI 1.38 to 6.34)) and endotoxin (aOR=1.95 (95% CI 1.04 to 3.64)) were associated with increased risk of current eczema. Furthermore, increased odds of NAE were associated with current exposure to animals (aOR=5.60 (95% CI 1.45 to 21.7)) and storage mites (aOR=5.63 (95% CI 1.45 to 21.9)). Current exposures to isocyanates (aOR=5.27 (95% CI 1.17 to 23.7)) and acrylates (aOR=8.41 (95% CI 1.60 to 44.3)) were associated with AE. There was no evidence of associations between cumulative exposures and eczema prevalence. Cumulative exposure to metalworking fluids (aOR=1.10 (95% CI 1.01 to 1.22)) was associated with NAE and acrylates (aOR=1.24 (95% CI 1.04 to 1.46)) with AE., Conclusions: In this exploratory assessment, multiple occupational exposures were associated with current eczema in middle-aged adults. Raising awareness and limiting these exposures during an individual's productive working life will likely have various health benefits, including reducing eczema prevalence., Competing Interests: Competing interests: SD, CJL, MA, JP and AJL declare they have received research funds from GSK’s competitively awarded Investigator Sponsored Studies programme, for unrelated research. AJL, SD and MA have received grant funding from Sanofi Regeneron for unrelated research. SD has received funds from AZ for unrelated research. AJL has received donations of interventional product (EpiCeram) from Primus Pharmaceuticals for unrelated research. JCS has been a consultant/speaker/investigator for AbbVie, Amgen, Bioderma, Bristol Myers Squibb, Ego Pharmaceuticals, Eli-Lilly, Janssen, LEO Pharma, L’Oreal, Mayne, Novartis, Pfizer, Pierre-Fabre, and Sanofi. MA holds investigator-initiated grants for unrelated research from Pfizer, Boehringer-Ingelheim and Sanofi. MA has also undertaken an unrelated consultancy for Sanofi. MA has also received a speaker’s fee from GSK., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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50. Impact of asthma on working life: an analysis of the French CONSTANCES cohort.
- Author
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Provost D, Delmas MC, Bénézet L, Ribet C, Chesneau J, Raherison C, Goldberg M, Dumas O, Le Moual N, and Iwatsubo Y
- Subjects
- Adult, Male, Humans, Female, Cross-Sectional Studies, Unemployment, Workplace, Employment, Asthma epidemiology
- Abstract
Objectives: Asthma has significant occupational consequences. The objective of our study was to investigate the links between asthma and the career path, taking into account gender and age at asthma onset., Methods: Using cross-sectional data collected at inclusion in the French CONSTANCES cohort in 2013-2014, we studied the links between each career path indicator (number of job periods, total duration of employment, numbers of part-time jobs and work interruptions due to unemployment or health issues, employment status at inclusion) on the one hand, and current asthma and asthma symptom score in the last 12 months on the other hand, as reported by the participants. Multivariate analyses were performed separately for men and women using logistic and negative binomial regression models adjusted for age, smoking status, body mass index and educational level., Results: When the asthma symptom score was used, significant associations were observed with all of the career path indicators studied: a high symptom score was associated with a shorter total duration of employment as well as a greater number of job periods, part-time jobs and work interruptions due to unemployment or health issues. These associations were of similar magnitude in men and women. When current asthma was used, the associations were more pronounced in women for some career path indicators., Conclusion: The career path of asthmatic adults is more often unfavourable than that of those without asthma. Efforts should be made to support people with asthma in the workplace, in order to maintain employment and facilitate the return to work., Competing Interests: Competing interests: MG reports grants or contracts from ANSES., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
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