Search

Based on the multi-degree of freedom in series model, structural displacement amplitude formula is derived in the frequency domain under the translation-rotation input situation, this formula indicates that the soil - structure interaction (SSI) could be considered as adding a correction term M˜ to the mass matrix of the structure with the hypothesis of Rigid foundation. This corrected mass matrix is actually a complex matrix, which related to the input frequency and damping. Equivalent translation-rotation input is coupled with two translation input components U* and Θ*. Besides, we uses case analysis to explain the characteristics of soil - structure interaction (SSI) in frequency domain by the end of this paper.

On the basis of hydrogeology investigation, the groundwater, river water, seawater and the medium in the lower reaches of the Dagu River were collected respectively, their compositions and nature were determined, then the permeability and the regularity of the main ions were determined during simulating seawater intrusion with transfusion installment. Finally, hydro-geochemical action was studied with the numerical simulation method during seawater intrusion. The result indicts that the mineral dissolution and precipitation take place with ion exchanges, Calcite is in a supersaturated situation after the percent of seawater reaches 40％; the saturation index of Gypsum arises gradually at first, and then decreases after the peak, finally it increases again but it is always in unsaturated condition from beginning to the end.

A reactive β-cyclodextrin (β-CD) based monomer carrying vinyl carylboxic acid functional groups was synthesized by reaction of β-CD with maleic anhydride (MAH). Through graft copolymerization of the monomer with acrylic acid (AAc), a novel hydrogel, poly(β-CD-g-AAc) hydrogel with molecular inclusion function plus pH-sensitivity, was prepared by free radical polymerization using a redox system as the initiator in an aqueous solution. The structure and properties were characterized by FT-IR, 13 C-NMR and elemental analysis. The equilibrium swelling ratio (ESR) was tested with different pH values. The results indicated that the ESR of the poly (β-CD-g-AAc) hydrogel presented marked variations following the change of pH values, and functioned in a transition region when pH values ranged from 4.5 to 5.5. Using drug Ketoprofen as a model molecule, the drug release from the poly (β-CD-g-AAc) hydrogel in pH 7.4 medium was higher than that in a medium with a pH 1.4. A low level of drug release from the poly (β-CD-g-AAc) hydrogels with a low content of β-CD can be obtained compared with high content of β-CD. When pH was modified across both simulated gastric and intestinal pH conditions, reversible pH-sensitive drug release behavior was observed.

To investigate theological properties of common hydrophilic gel excipients such as Carbopol based on viscosity, the viscosity was determined by rotation method and falling-ball method. Linear regression was made between ln(eta) and concentration, the slope of which was used to explore the relation between viscosity and concentration of different excipients. The viscosity flow active energy (E(eta)) was calculated according to Arrhenius equation and was used to investigate the relation between viscosity and temperature of different excipients. The results showed that viscosities measured by two methods were consistent. Concentration of guargum (GG) and hydroxypropylmethyl cellulose (HPMC) solution had a great influence on the viscosity, k5; while concentration of polyvinylpyrrolidone-K30 (PVP-K30) and polyethylene glycol 6000 (PEG6000) exerted a less effect on viscosity, k0.2; viscosity flow active energy of different excipients were close, which ranged from 30 to 40 kJ x mol(-1). Therefore, theological properties study could provide the basis for application of excipients and establish a foundation for the research of relation between excipients structure, property and function.

To observe the therapeutic effect on treatment of acne with acupuncture plus moving cupping and blood-letting. Sixty acne cases were randomized into the treatment group for combined acupuncture and moving cupping and blood-letting and control group for acupuncture alone. The therapeutic effects of the cases in the two groups were observed after a 30-day treatment. The total effective rate was significantly higher in the treatment group than in the control group (P

The inclusion complex of isotretinoin was prepared by sealed-control temperature method and amylose was used as carrier. The formation of inclusion complex was confirmed by powder X-ray diffraction and DSC. The equation of enzymatically-controlled drug release was established by kinetic theory, and the release characteristic of drug was confirmed by using the kinetic equation. The results show that the drug release was attributed to first order reaction without alpha-amylase. However, with alpha-amylase, the drug release was an acceleration process by the effect of both dissociation and enzymatic hydrolysis simultaneously. The research indicates that drug release from the inclusion complex was modulated by the addition of alpha-amylase.

The purpose of the present study is to use beta-cyclodextrin polymers (beta-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of beta-CDP on its drug loading and release behaviors. A series of beta-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and 13C NMR spectrum. The beta-CDP was systemically characterized for the relation between the CLD of beta-CDP and the drug loading and release as well. The results of FT-IR and 13C NMR showed that similar peak-shaped vibration of beta-CDP and beta-CD implies that the polymer keeps the original characteristic structure of beta-CD. The CLD of the beta-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.

The inclusion compound of amylose and salicylic acid (SA) was prepared by a sealed temperature control method, and the formation of the inclusion compound was confirmed by IR spectrum and powder X-ray diffraction. The kinetic parameters of dissociation of amylose/SA compound were studied by the nonisothermal method which was defined as a relationship between the dissociation ratio and time. The values of activation energy (Ea) and frequency factors (InA) were calculated by a nonlinear least-square method. In this study, the formation of the inclusion compound of amylose/SA was confirmed by IR spectrum powder X-ray diffraction. SA existed in a molecule form in the spiral stouction of amylose. The dissociation of amylose/SA compound was attributed to first order reaction. The values of Ea calculated by the nor-isothermal method were 21.71 and 22.41 kJ x mol(-1) at heating rate 5 and 10 degrees C x h(-1), respectively. The corresponding isothermal method value of Ea was 22.17 kJ x mol(-1); the calculated InA values were 9.32 and 10.08 at heating rate 5 and 10 degrees C x h(-1), respectively. The corresponding isothermal method lnA value was 9.26. The results were in good agreement with Ea values and lnA values by isothermal method. These results indicated that the non-isothermal method described in this study could be adequately used for the stability study of inclusion compound and was a rapid and accurate method for the determination of kinetic parameters.

In the present study, using paeonol as model drug, a new sealed-control temperature method of preparing inclusion complex was developed, the effects of heating temperature, heating time, and crystallinity of beta-cyclodextrin (beta-CD) on formation of inclusion complex and release of the drug were investigated.A physical mixture of paeonol and beta-CD was sealed in a container, and heated at the desired temperature for the specified time. The inclusion complex of paeonol and beta-CD was confirmed by IR spectrum and powder X-ray diffraction.The results indicated that the inclusion complex formation of paeonol beta-CD by sealed-control temperature method was affected by heating temperature, heating time, and crystallinity of beta-CD. The inclusion complex was able to inhibit sublimation of paeonol, and dissolution rate of paeonol was increased when the paeonol was included by beta-CD.Preparation of inclusion complex was simple and quick by sealed-control temperature method.

To promote the study on standardization of needling depth of acupoints, ensure safety of needling, and promote internationally academic exchanges of acupuncture and moxibustion.Study, analyze ancient and present literature of acupuncture and moxibustion, and compare the differences in needling depth, measure unit, description methods, and the causes and trend, and indicate confusion at present, and put forward a proposition for establishing standardization of needling depth.There are a lot of confusions in needling depth of acupoints from the ancient times to the present, which produces severe unfavorable influence on standardization and international exchanges of acupuncture and moxibustion science, and it remains to be studied for the standardization as early as possibly.