1. Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility
- Author
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Reidar Fossmark, Tom C. Martinsen, and Helge L. Waldum
- Subjects
proton pump inhibitors ,adverse effects ,gastrin ,gastric cancer ,renal disease ,liver disease ,fracture risk ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential side effects are causal. However, important evidence from experimental and mechanistic studies that could support a causal relationship may have been underestimated by epidemiologists and meta-analysists. In the current manuscript we review the combined epidemiological and mechanistic evidence of the adverse effects of PPI use.
- Published
- 2019
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