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116 results on '"Wensing, A. M.J."'

1. Intervention strategies to improve adherence to treatment for selected chronic conditions in sub‐Saharan Africa: a systematic review

Author

Gumede, Siphamandla Bonga, Wit, John B.F., Venter, Willem D.F., Wensing, Annemarie M.J., and Lalla‐Edward, Samanta Tresha

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Patient compliance -- Analysis, Group counseling -- Analysis, Highly active antiretroviral therapy -- Analysis, Hypoglycemic agents -- Analysis, Mediation -- Analysis, Social networks -- Analysis, Evidence-based medicine -- Analysis, Hypertension -- Care and treatment, Health
Abstract

: Introduction: Evidence‐based intervention strategies to improve adherence among individuals living with chronic conditions are critical in ensuring better outcomes. In this systematic review, we assessed the impact of interventions that aimed to promote adherence to treatment for chronic conditions. Methods: We systematically searched PubMed, Web of Science, Scopus, Google Scholar and CINAHL databases to identify relevant studies published between the years 2000 and 2023 and used the QUIPS assessment tool to assess the quality and risk of bias of each study. We extracted data from eligible studies for study characteristics and description of interventions for the study populations of interest. Results: Of the 32,698 total studies/records screened, 2814 were eligible for abstract screening and of those, 497 were eligible for full‐text screening. A total of 82 studies were subsequently included, describing a total of 58,043 patients. Of the total included studies, 58 (70.7%) were related to antiretroviral therapy for HIV, 6 (7.3%) were anti‐hypertensive medication‐related, 12 (14.6%) were anti‐diabetic medication‐related and 6 (7.3%) focused on medication for more than one condition. A total of 54/82 (65.9%) reported improved adherence based on the described study outcomes, 13/82 (15.9%) did not have clear results or defined outcomes, while 15/82 (18.3%) reported no significant difference between studied groups. The 82 publications described 98 unique interventions (some studies described more than one intervention). Among these intervention strategies, 13 (13.3%) were multifaceted (4/13 [30.8%] multi‐component health services‐ and community‐based programmes, 6/13 [46.2%] included individual plus group counselling and 3/13 [23.1%] included SMS or alarm reminders plus individual counselling). Discussion: The interventions described in this review ranged from adherence counselling to more complex interventions such as mobile health (mhealth) interventions. Combined interventions comprised of different components may be more effective than using a single component in isolation. However, the complexity involved in designing and implementing combined interventions often complicates the practicalities of such interventions. Conclusions: There is substantial evidence that community‐ and home‐based interventions, digital health interventions and adherence counselling interventions can improve adherence to medication for chronic conditions. Future research should answer if existing interventions can be used to develop less complicated multifaceted adherence intervention strategies., INTRODUCTION Patients on treatment for chronic conditions face multiple barriers to adherence, and no single intervention is deemed sufficient to ensure that high levels of adherence to treatment are maintained [...]

Published
2024
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2. Recommendations on data sharing in HIV drug resistance research

Author

Inzaule, Seth C., Siedner, Mark J., Little, Susan J., Avila-Rios, Santiago, Ayitewala, Alisen, Bosch, Ronald J., Calvez, Vincent, Ceccherini-Silberstein, Francesca, Charpentier, Charlotte, Descamps, Diane, Eshleman, Susan H., Fokam, Joseph, Frenkel, Lisa M., Gupta, Ravindra K., Ioannidis, John P.A., Kaleebu, Pontiano, Kantor, Rami, Kassaye, Seble G., Kosakovsky Pond, Sergei L., Kouamou, Vinie, Kouyos, Roger D., Kuritzkes, Daniel R., Lessells, Richard, Marcelin, Anne-Genevieve, Mbuagbaw, Lawrence, Minalga, Brian, Ndembi, Nicaise, Neher, Richard A., Paredes, Roger, Pillay, Deenan, Raizes, Elliot G., Rhee, Soo-Yon, Richman, Douglas D., Ruxrungtham, Kiat, Sabeti, Pardis C., Schapiro, Jonathan M., Sirivichayakul, Sunee, Steegen, Kim, Sugiura, Wataru, van Zyl, Gert U., Vandamme, Anne-Mieke, Wensing, Annemarie M.J., Wertheim, Joel O., Gunthard, Huldrych F., Jordan, Michael R., and Shafer, Robert W.

Subjects
United States. Centers for Disease Control and Prevention, United States. National Institutes of Health, Merck & Company Inc., Gilead Sciences Inc., Biological products industry, HIV (Viruses) -- Drug therapy, Rilpivirine, Drug resistance -- Drug therapy, Pharmaceutical industry, Biological sciences, World Health Organization
Abstract

Author(s): Seth C. Inzaule 1, Mark J. Siedner 2, Susan J. Little 3, Santiago Avila-Rios 4, Alisen Ayitewala 5, Ronald J. Bosch 6, Vincent Calvez 7, Francesca Ceccherini-Silberstein 8, Charlotte [...]

Published
2023
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4. Is there a role for doravirine in African HIV treatment programmes? A large observational resistance study in South Africa

Author

Steegen, Kim, Moorhouse, Michelle, Wensing, Annemarie M.J., Venter, Willem D.F., and Hans, Lucia

Subjects
Drug resistance -- Testing, Public health administration -- Evaluation, HIV infection -- Drug therapy, Health
Abstract

Introduction: Dolutegravir has replaced efavirenz in most low- and middle-income countries, due to better tolerability and formidable resistance profile, but dolutegravir side effects suggest alternatives are needed. We evaluated doravirine resistance in South Africa as a first step to assess whether doravirine may replace dolutegravir. Methods: A retrospective dataset was analysed for predicted doravirine susceptibility including sequences obtained from three patient groups. First, data from 277 patients initiating antiretroviral treatment (ART) were collected between February 2013 and October 2014 as part of a national survey. Second, data from 788 patients experiencing NNRTI-based ART failure were obtained between February 2013 and October 2014 as part of a national survey. Third, data derived from 584 patients who had genotypic drug resistance testing requested after NNRT-based failure as part of individual patient management between January 2016 and December 2019. Pol sequences were generated using validated population-based in-house genotyping and submitted to Stanford HIVdb v8.9. Results and discussion: Less than 5% of patients initiating ART presented with genotypic doravirine resistance, whereas most patients experiencing NNRTI-based ART failure presented with predicted intermediate (41.0%) or high-level resistance (43.8%) to doravirine. High-level resistance to doravirine was commonly predicted by the presence of at least three DRMs (79.7%). The predicted resistance profile to doravirine in ART-naive patients is promising, but less so in those experiencing failure to first-generation NNRTIs. Accumulation of NNRTI DRMs seems to be an important factor in the poor resistance prediction for doravirine. Conclusions: Although doravirine is approved as initial therapy in patients who are ART-naTve, it is currently recommended to obtain a genotype prior to the initiation of ART. Clinical studies are needed to ascertain whether predicted resistance profiles in ART naive and NNRTI-treated patients translate into poor clinical outcomes, especially in settings where genotypic resistance testing is not available. Keywords: HIV; drug resistance; antiretroviral treatment; doravirine; subtype C; South Africa, 1 | INTRODUCTION South Africa has the largest HIV epidemic globally with 7.5 million estimated infections and approximately 5.2 million HIV-infected people on antiretroviral treatment (ART) making it the biggest [...]

Published
2021
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7. Drug level testing as a strategy to determine eligibility for drug resistance testing after failure of ART: a retrospective analysis of South African adult patients on second-line ART

Author

Hermans, Lucas E., Steegen, Kim, Heine, Robter, Schuurman, Rob, Tempelman, Hugo A., Moraba, Robert, Maarseveen, Erikvan, Nijhuis, Monique, Pillay, Taryn, Legg-E'Silva, Derryn, Snyman, Tracy, Schapiro, Jonathan M., Burger, David M., Carmona, Sergio, and Wensing, Annemarie M.J.

Subjects
Medical tests -- Usage -- Analysis, Highly active antiretroviral therapy -- Analysis -- Usage, Atazanavir -- Usage, Liquid chromatography -- Analysis -- Usage, Drug resistance -- Analysis -- Usage, Proteases -- Usage, Mass spectrometry -- Analysis -- Usage, EDTA -- Usage, Adults -- Analysis -- Usage, Health
Abstract

Introduction: When protease inhibitor (PI)-based second-line ART fails, guidelines recommend drug resistance testing and individualized third-line treatment. However, PI-resistant viral strains are rare and drug resistance testing is costly. We investigated whether less costly PI-exposure testing can be used to select those patients who would benefit most from drug resistance testing. Methods: We performed a retrospective analysis of South African adults living with HIV experiencing failure of ritonavir-boosted-lopinavi (LPV/r)-based second-line ART for whom drug resistance testing results were available. We included patients who received plasma-based drug resistance testing at a central South African reference laboratory in 2017 and patients who received dried blood spots (DBS)-based drug resistance testing at a rural South African clinic between 2009 and 2017. PI-exposure testing was performed on remnant plasma or DBS using liquid chromatography mass spectrometry (LCMS). Additionally, a low-cost immunoassay was used on plasma. Population genotypic drug resistance testing of the pol region was performed on plasma and DBS using standard clinical protocols. Results: Samples from 544 patients (494 plasma samples and 50 DBS) were included. Median age was 41.0 years (IQR: 33.3 to 48.5) and 58.6% were women. Median HIV-RNA load was 4.9 log10 copies/mL (4.3 to 5.4). Prevalence of resistance to the NRTI-backbone was 70.6% (349/494) in plasma samples and 56.0% (28/50) in DBS. Major PI-resistance mutations conferring high-level resistance to LPV/r were observed in 26.7% (132/494) of plasma samples and 12% (6/50) of DBS. PI-exposure testing revealed undetectable LPV levels in 47.0% (232/494) of plasma samples and in 60.0% (30/50) of DBS. In pooled analysis of plasma and DBS samples, detectable LPV levels had a sensitivity of 90% (84% to 94%) and a negative predictive failure of 95% (91% to 97%) for the presence of major LPV/r resistance. Conclusions: PI-exposure testing revealed non-adherence in half of patients experiencing failure on second-line ART and accurately predicted the presence or absence of clinically relevant PI resistance. PI-exposure testing constitutes a novel screening strategy in patients with virological failure of ART that can differentiate between different underlying causes of therapy failure and may allow for more effective use of limited resources available for drug resistance testing. Keywords: antiretroviral treatment; treatment failure; HIV drug resistance; adherence; drug level testing; low- and middle-income countries, 1 | INTRODUCTION Antiretroviral treatment (ART) programmes are expanding rapidly to people living with HIV in low- and middle-income countries (LMIC) in an effort to control the HIV epidemic. First-line [...]

Published
2020
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8. Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C

Author

MMB Research line 3b, Infection & Immunity, Urologie Medisch Kinderen, MMB, Regenerative Medicine and Stem Cells, MMB Research line 3a, Buchholtz, N. V.E.J., Nühn, M. M., de Jong, T. C.M., Stienstra, T. A.T., Reddy, K., Ndung’u, T., Ndhlovu, Z. M., Fisher, K., Palmer, S., Wensing, A. M.J., Symons, J., Nijhuis, M., MMB Research line 3b, Infection & Immunity, Urologie Medisch Kinderen, MMB, Regenerative Medicine and Stem Cells, MMB Research line 3a, Buchholtz, N. V.E.J., Nühn, M. M., de Jong, T. C.M., Stienstra, T. A.T., Reddy, K., Ndung’u, T., Ndhlovu, Z. M., Fisher, K., Palmer, S., Wensing, A. M.J., Symons, J., and Nijhuis, M.

Published
2024

9. Periodontal inflammation as a potential driver of HIV low level viremia

Author

MMB, MMB Medische Staf, Healthcare Innovation & Evaluation, Infection & Immunity, MMB Research line 3a, Stam, Arjen J., Groenewegen, Hester, Vissink, Arjan, Wensing, Annemarie M.J., Nijhuis, Monique, Bierman, Wouter F.W., MMB, MMB Medische Staf, Healthcare Innovation & Evaluation, Infection & Immunity, MMB Research line 3a, Stam, Arjen J., Groenewegen, Hester, Vissink, Arjan, Wensing, Annemarie M.J., Nijhuis, Monique, and Bierman, Wouter F.W.

Published
2024

11. Dynamics of Low-Level Viremia and Immune Activation after Switching to a Darunavir-Based Regimen

Author

MMB Medische Staf, MMB Research line 3b, Infection & Immunity, MS Interne Geneeskunde, Epidemiology & Health Economics, MS Reumatologie/Immunologie/Infectie, MS Infectieziekten, CTI CFF, Apotheek Opleiding, MMB Research line 3a, MMB, Stam, Arjen J., Buchholtz, Ninée V.E.J., Bierman, Wouter F.W., van Crevel, Reinout, Hoepelman, Andy I.M., Claassen, Mark A.A., Ammerlaan, Heidi S.M., van Welzen, Berend J., van Kasteren, Marjo E.E., van Lelyveld, Steven F.L., de Jong, Dorien, Tesselaar, Kiki, van Luin, Matthijs, Nijhuis, Monique, Wensing, Annemarie M.J., Lowerit Study Team, Study Team, MMB Medische Staf, MMB Research line 3b, Infection & Immunity, MS Interne Geneeskunde, Epidemiology & Health Economics, MS Reumatologie/Immunologie/Infectie, MS Infectieziekten, CTI CFF, Apotheek Opleiding, MMB Research line 3a, MMB, Stam, Arjen J., Buchholtz, Ninée V.E.J., Bierman, Wouter F.W., van Crevel, Reinout, Hoepelman, Andy I.M., Claassen, Mark A.A., Ammerlaan, Heidi S.M., van Welzen, Berend J., van Kasteren, Marjo E.E., van Lelyveld, Steven F.L., de Jong, Dorien, Tesselaar, Kiki, van Luin, Matthijs, Nijhuis, Monique, Wensing, Annemarie M.J., and Lowerit Study Team, Study Team

Published
2024

16. Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variants compared with Alpha variant in vaccinated individuals

Author

Andeweg, Stijn P., Vennema, Harry, Veldhuijzen, Irene, Smorenburg, Naomi, Schmitz, Dennis, Zwagemaker, Florian, Van Gageldonk-Lafeber, Arianne B., Hahne, Susan J.M., Reusken, Chantal, Knol, Mirjam J., Eggink, Dirk, Schinkel, Janke, Welkers, Matthijs R.A., Jonges, Marcel, Koopsen, Jelle, Jong, Menno D.de, Molenkamp, Richard, Nieuwenhuijse, David F., Sikkema, Reina S., Munnink, Bas B.Oude, Koopmans, Marion, van der Zanden, Adri, Manrho, Laura, Beer, Jessica de, Boers, Stefan A., Meijers, Erin, Vreeswijk, Tom, Sidorov, Igor A., Dunk, Djoo, Smit, Pieter W., Pas, Suzan D., Verweij, Jaco J., Stohr, Joep J.J.M., Dingemans, Jozef, Veer, Brian van der, Alphen, Lieke van, Savelkoul, Paul, Niesters, Hubert G.M., Forero, Erley F.Lizarazo, Fliss, Monika A., Gard, Lilli, Tanja, Anniek A.N., Schuurman10, Rob, Wensing, Annemarie M.J., Hofstra, L. Marije, Wertheim, Heiman F.L., Faber, Timor, Kroneman, Annelies, Mulder, Maarten, Schipper, Maarten, Andeweg, Stijn P., Vennema, Harry, Veldhuijzen, Irene, Smorenburg, Naomi, Schmitz, Dennis, Zwagemaker, Florian, Van Gageldonk-Lafeber, Arianne B., Hahne, Susan J.M., Reusken, Chantal, Knol, Mirjam J., Eggink, Dirk, Schinkel, Janke, Welkers, Matthijs R.A., Jonges, Marcel, Koopsen, Jelle, Jong, Menno D.de, Molenkamp, Richard, Nieuwenhuijse, David F., Sikkema, Reina S., Munnink, Bas B.Oude, Koopmans, Marion, van der Zanden, Adri, Manrho, Laura, Beer, Jessica de, Boers, Stefan A., Meijers, Erin, Vreeswijk, Tom, Sidorov, Igor A., Dunk, Djoo, Smit, Pieter W., Pas, Suzan D., Verweij, Jaco J., Stohr, Joep J.J.M., Dingemans, Jozef, Veer, Brian van der, Alphen, Lieke van, Savelkoul, Paul, Niesters, Hubert G.M., Forero, Erley F.Lizarazo, Fliss, Monika A., Gard, Lilli, Tanja, Anniek A.N., Schuurman10, Rob, Wensing, Annemarie M.J., Hofstra, L. Marije, Wertheim, Heiman F.L., Faber, Timor, Kroneman, Annelies, Mulder, Maarten, and Schipper, Maarten

Abstract

The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared with the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14 to 59 days after complete vaccination compared with ≥60 days. In contrast to vaccine-induced immunity, there was no increased risk for reinfection with Beta, Gamma, or Delta variants relative to the Alpha variant in individuals with infection-induced immunity.

Published
2023

17. Integrated analysis of viral blips, residual viremia, and associated factors in people with HIV: Results from a retrospective cohort study

Author

MS Interne Geneeskunde, MMB Research line 3b, DIGD-Medisch 1, Infection & Immunity, MMB, Oomen, Patrick G.A., Dijkstra, Suzan, Hofstra, L. Marije, Nijhuis, Monique M., Verbon, Annelies, Mudrikova, Tania, Wensing, Annemarie M.J., Hoepelman, Andy I.M., Van Welzen, Berend J., MS Interne Geneeskunde, MMB Research line 3b, DIGD-Medisch 1, Infection & Immunity, MMB, Oomen, Patrick G.A., Dijkstra, Suzan, Hofstra, L. Marije, Nijhuis, Monique M., Verbon, Annelies, Mudrikova, Tania, Wensing, Annemarie M.J., Hoepelman, Andy I.M., and Van Welzen, Berend J.

Published
2023

18. Predictors of Treatment Adherence and Virological Failure Among People Living with HIV Receiving Antiretroviral Therapy in a South African Rural Community: A Sub-study of the ITREMA Randomised Clinical Trial

Author

MMB, Infection & Immunity, Divisieleiding, MMB RZN, MMB Research line 3b, Medische Microbiologie, Gumede, Siphamandla B., Wensing, Annemarie M.J., Lalla-Edward, Samanta T., de Wit, John B.F., Francois Venter, W. D., Tempelman, Hugo A., Hermans, Lucas E., MMB, Infection & Immunity, Divisieleiding, MMB RZN, MMB Research line 3b, Medische Microbiologie, Gumede, Siphamandla B., Wensing, Annemarie M.J., Lalla-Edward, Samanta T., de Wit, John B.F., Francois Venter, W. D., Tempelman, Hugo A., and Hermans, Lucas E.

Published
2023

19. Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19

Author

Clinical Virology, MMB opleiding Arts microbioloog, Infection & Immunity, Arts Assistenten Longziekten, Longziekten onderzoek 1, Longziekten patientenzorg, MGGZ, Longziekten onderzoek 2, Onderzoek, Child Health, Regenerative Medicine and Stem Cells, MMB Research line 3a, MMB, Rümke, Lidewij W., Smit, Wouter L., Bossink, Ailko, Limonard, Gijs J.M., Muilwijk, Danya, Haas, Lenneke E.M., Reusken, Chantal, van der Wal, Sanne, Thio, Bing J., van Os, Yvonne M.G., Gremmels, Hendrik, Beekman, Jeffrey M., Nijhuis, Monique, Wensing, Annemarie M.J., Heron, Michiel, Thijsen, Steven F.T., Clinical Virology, MMB opleiding Arts microbioloog, Infection & Immunity, Arts Assistenten Longziekten, Longziekten onderzoek 1, Longziekten patientenzorg, MGGZ, Longziekten onderzoek 2, Onderzoek, Child Health, Regenerative Medicine and Stem Cells, MMB Research line 3a, MMB, Rümke, Lidewij W., Smit, Wouter L., Bossink, Ailko, Limonard, Gijs J.M., Muilwijk, Danya, Haas, Lenneke E.M., Reusken, Chantal, van der Wal, Sanne, Thio, Bing J., van Os, Yvonne M.G., Gremmels, Hendrik, Beekman, Jeffrey M., Nijhuis, Monique, Wensing, Annemarie M.J., Heron, Michiel, and Thijsen, Steven F.T.

Published
2023

20. Prevalence, incidence and recurrence of sexually transmitted infections in HIV-negative adult women in a rural South African setting

Author

MMB, MMB opleiding Arts microbioloog, Infection & Immunity, Divisieleiding, Medische Microbiologie, Huyveneers, Laura E.P., Maphanga, Mathapelo, Umunnakwe, Chijioke N., Bosman-de Boer, Larissa, Moraba, Robert S., Tempelman, Hugo A., Wensing, Annemarie M.J., Hermans, Lucas E., MMB, MMB opleiding Arts microbioloog, Infection & Immunity, Divisieleiding, Medische Microbiologie, Huyveneers, Laura E.P., Maphanga, Mathapelo, Umunnakwe, Chijioke N., Bosman-de Boer, Larissa, Moraba, Robert S., Tempelman, Hugo A., Wensing, Annemarie M.J., and Hermans, Lucas E.

Published
2023

21. Point-of-Care Tenofovir Urine Testing for the Prediction of Treatment Failure and Drug Resistance During Initial Treatment for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Author

MMB, Medische Microbiologie, Divisieleiding, UMC Utrecht, Infection & Immunity, Hermans, Lucas E., Umunnakwe, Chijioke N., Lalla-Edward, Samanta T., Hebel, Shane K., Tempelman, Hugo A., Nijhuis, Monique, Venter, Willem D.F., Wensing, Annemarie M.J., MMB, Medische Microbiologie, Divisieleiding, UMC Utrecht, Infection & Immunity, Hermans, Lucas E., Umunnakwe, Chijioke N., Lalla-Edward, Samanta T., Hebel, Shane K., Tempelman, Hugo A., Nijhuis, Monique, Venter, Willem D.F., and Wensing, Annemarie M.J.

Published
2023

22. A randomized study of intensified antiretroviral treatment monitoring versus standard-of-care for prevention of drug resistance and antiretroviral treatment switch

Author

Hermans, Lucas E., primary, Ter Heine, Rob, additional, Schuurman, Rob, additional, Tempelman, Hugo A., additional, Burger, David M., additional, Vervoort, Sigrid C.J.M., additional, Deville, Walter L.J.M., additional, De Jong, Dorien, additional, Venter, Willem D.F., additional, Nijhuis, Monique, additional, and Wensing, Annemarie M.J., additional

Published
2022
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23. Shock and kill within the CNS: A promising HIV eradication approach?

Author

MMB Research line 3b, Infection & Immunity, MMB, MMB Research line 3a, Nühn, Marieke M., Gumbs, Stephanie B.H., Buchholtz, Ninée V.E.J., Jannink, Lisanne M., Gharu, Lavina, de Witte, Lot D., Wensing, Annemarie M.J., Lewin, Sharon R., Nijhuis, Monique, Symons, Jori, MMB Research line 3b, Infection & Immunity, MMB, MMB Research line 3a, Nühn, Marieke M., Gumbs, Stephanie B.H., Buchholtz, Ninée V.E.J., Jannink, Lisanne M., Gharu, Lavina, de Witte, Lot D., Wensing, Annemarie M.J., Lewin, Sharon R., Nijhuis, Monique, and Symons, Jori

Published
2022

24. HIV-1 pretreatment drug resistance negatively impacts outcomes of first-line antiretroviral treatment

Author

Clinical Virology, Medische Microbiologie, MMB Research line 3b, MMB Staf diagnostiek, Infection & Immunity, MMB, Divisieleiding, MMB Research line 3a, MMB opleiding Arts microbioloog, Hermans, Lucas E., Hofstra, Laura M., Schuurman, Rob, Ter Heine, Rob, Burger, David M., Talboom, Stijn A.J., De Jong, Dorien, Tempelman, Hugo A., Venter, Willem D.F., Nijhuis, Monique, Wensing, Annemarie M.J., Clinical Virology, Medische Microbiologie, MMB Research line 3b, MMB Staf diagnostiek, Infection & Immunity, MMB, Divisieleiding, MMB Research line 3a, MMB opleiding Arts microbioloog, Hermans, Lucas E., Hofstra, Laura M., Schuurman, Rob, Ter Heine, Rob, Burger, David M., Talboom, Stijn A.J., De Jong, Dorien, Tempelman, Hugo A., Venter, Willem D.F., Nijhuis, Monique, and Wensing, Annemarie M.J.

Published
2022

25. A randomized study of intensified antiretroviral treatment monitoring versus standard-of-care for prevention of drug resistance and antiretroviral treatment switch: week 96 results of the ITREMA trial

Author

Clinical Virology, Medische Microbiologie, MMB Staf diagnostiek, Infection & Immunity, Divisieleiding, Verplegingswetenschap, Cancer, Global Health, MMB, MMB Research line 3a, Hermans, Lucas E., Ter Heine, Rob, Schuurman, Rob, Tempelman, Hugo A., Burger, David M., Vervoort, Sigrid C.J.M., Deville, Walter L.J.M., De Jong, Dorien, Venter, Willem D.F., Nijhuis, Monique, Wensing, Annemarie M.J., Clinical Virology, Medische Microbiologie, MMB Staf diagnostiek, Infection & Immunity, Divisieleiding, Verplegingswetenschap, Cancer, Global Health, MMB, MMB Research line 3a, Hermans, Lucas E., Ter Heine, Rob, Schuurman, Rob, Tempelman, Hugo A., Burger, David M., Vervoort, Sigrid C.J.M., Deville, Walter L.J.M., De Jong, Dorien, Venter, Willem D.F., Nijhuis, Monique, and Wensing, Annemarie M.J.

Published
2022

26. Lower Incidence of HIV-1 Blips Observed during Integrase Inhibitor-Based Combination Antiretroviral Therapy

Author

MMB Research line 3b, MS Interne Geneeskunde, Infection & Immunity, MMB, MMB opleiding Arts microbioloog, Dijkstra, Suzan, Hofstra, L. Marije, Mudrikova, Tania, Wensing, Annemarie M.J., Oomen, Patrick G.A., Hoepelman, Andy I.M., Van Welzen, Berend J., MMB Research line 3b, MS Interne Geneeskunde, Infection & Immunity, MMB, MMB opleiding Arts microbioloog, Dijkstra, Suzan, Hofstra, L. Marije, Mudrikova, Tania, Wensing, Annemarie M.J., Oomen, Patrick G.A., Hoepelman, Andy I.M., and Van Welzen, Berend J.

Published
2022

27. Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analyses

Author

MMB Research line 3b, Infection & Immunity, MMB, AIOS Psychiatrie, Onderzoeksgroep 5, MMB opleiding Arts microbioloog, MMB Research line 3a, Gumbs, Stephanie B.H., Kübler, Raphael, Gharu, Lavina, Schipper, Pauline J., Borst, Anne L., Snijders, Gijsje J.L.J., Ormel, Paul R., van Berlekom, Amber Berdenis, Wensing, Annemarie M.J., de Witte, Lot D., Nijhuis, Monique, MMB Research line 3b, Infection & Immunity, MMB, AIOS Psychiatrie, Onderzoeksgroep 5, MMB opleiding Arts microbioloog, MMB Research line 3a, Gumbs, Stephanie B.H., Kübler, Raphael, Gharu, Lavina, Schipper, Pauline J., Borst, Anne L., Snijders, Gijsje J.L.J., Ormel, Paul R., van Berlekom, Amber Berdenis, Wensing, Annemarie M.J., de Witte, Lot D., and Nijhuis, Monique

Published
2022

28. Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids

Author

MMB Research line 3b, Infection & Immunity, Onderzoeksgroep 2, MMB, Brain, Onderzoeksgroep 5, MMB opleiding Arts microbioloog, MMB Research line 3a, Gumbs, Stephanie B.H., Berdenis van Berlekom, Amber, Kübler, Raphael, Schipper, Pauline J., Gharu, Lavina, Boks, Marco P., Ormel, Paul R., Wensing, Annemarie M.J., de Witte, Lot D., Nijhuis, Monique, MMB Research line 3b, Infection & Immunity, Onderzoeksgroep 2, MMB, Brain, Onderzoeksgroep 5, MMB opleiding Arts microbioloog, MMB Research line 3a, Gumbs, Stephanie B.H., Berdenis van Berlekom, Amber, Kübler, Raphael, Schipper, Pauline J., Gharu, Lavina, Boks, Marco P., Ormel, Paul R., Wensing, Annemarie M.J., de Witte, Lot D., and Nijhuis, Monique

Published
2022

34. Point-of-Care Detection of Nonadherence to Antiretroviral Treatment for HIV-1 in Resource-Limited Settings Using Drug Level Testing for Efavirenz, Lopinavir, and Dolutegravir: A Validation and Pharmacokinetic Simulation Study

Author

Medische Microbiologie, MMB Research line 3a, Infection & Immunity, MMB Staf diagnostiek, MMB opleiding Arts microbioloog, Hermans, Lucas E., Nijhuis, Monique, Tempelman, Hugo A., Houts, Tom, Schuurman, Rob, Burger, David M., Wensing, Annemarie M.J., Heine, Rob Ter, Medische Microbiologie, MMB Research line 3a, Infection & Immunity, MMB Staf diagnostiek, MMB opleiding Arts microbioloog, Hermans, Lucas E., Nijhuis, Monique, Tempelman, Hugo A., Houts, Tom, Schuurman, Rob, Burger, David M., Wensing, Annemarie M.J., and Heine, Rob Ter

Published
2021

35. The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes

Author

van de Vijver, David, Wensing, Annemarie M.J., Angarano, Gioacchino, Asjo, Birgitta, Balotta, Claudia, De Luca, Andrea, Derdelinckx, Inge, Maljkovic, Irina, de Mendoza, Carmen, Meyer, Laurence, Nielsen, Claus, de Coul, Eline L.M. Op, Ormaasen, Vidar, Paraskevis, Dimitris, Perrin, Luc, Puchhammer-Stockl, Elisabeth, Ruiz, Lidia, Salminen, Mika, Schmit, Jean-Claude, Schneider, Francois, Schuurman, Rob, Soriano, Vincent, Stanczak, Grzegorz, Stanojevic, Maja, Vandamme, Anne-Mieke, Laethem, Kristel Van, Violin, Michela, Wilbe, Karin, Yerly, Sabine, Zazzi, Maurizio, Boucher, Charles A.B.X, Grossman, Zehava, Hamouda, Osamah, Hulzokis, Angelos, Hemmer, Robert, Hoepelman, Andy, Horban, Andrzej, Korn, Klaus, Kucherer, Claudia, Leitner, Thomas, Loveday, Clive, and MacRae, Eilidh

Subjects
HIV patients -- Care and treatment, HIV patients -- Genetic aspects, HIV infection -- Care and treatment, HIV infection -- Genetic aspects, Drug resistance -- Genetic aspects, Health
Abstract

The genetic barrier between subtypes are compared using some 2000 HIV-1 sequences (>600 of non-B subtype) isolated from anti-retroviral-naive patients in Europe. Based on the calculated genetic barrier, the rate of drug resistance development may be similar for different HIV-1 subtypes.

Published
2006

38. Real-life validation of the Panbio COVID-19 Antigen Rapid Test (Abbott) in community-dwelling subjects with symptoms of potential SARS-CoV-2 infection

Author

Gremmels, Hendrik, primary, Winkel, Beatrice M.F., additional, Schuurman, Rob, additional, Rosingh, Andert, additional, Rigter, Nicolette A.M., additional, Rodriguez, Olga, additional, Ubijaan, Johan, additional, Wensing, Annemarie M.J., additional, Bonten, Marc J.M., additional, and Hofstra, L.Marije, additional

Published
2020
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39. Transmission of drug-resistant HIV-1 is stabilizing in Europe

Author

Vercauteren, Jurgen, Wensing, Annemarie M.J., van de Vijver, David A.M.C., Albert, Jan, Balotta, Claudia, Hamouda, Osamah, Kucherer, Claudia, Struck, Daniel, Schmit, Jean-Claude, Asjo, Birgitta, Bruckova, Marie, Camacho, Ricardo J., Clotet, Bonaventura, Coughlan, Suzie, Grossman, Zehava, Horban, Andrzej, Korn, Klaus, Kostrikis, Leondios, Nielsen, Claus, Paraskevis, Dimitrios, Poljak, Mario, Puchhammer-Stockl, Elisabeth, Riva, Chiara, Ruiz, Lidia, Salminen, Mika, Schuurman, Rob, Sonnerborg, Anders, Stanekova, Danica, Stanojevic, Maja, Vandamme, Anne-Mieke, and Boucher, Charles A.B.

Subjects
Drug resistance -- Research, Disease transmission -- Research, Disease transmission -- Physiological aspects, T cells -- Research, T cells -- Physiological aspects, HIV infection -- Diagnosis, Health
Published
2009

40. Failure of treatment with first-line Lopinavir boosted with Ritonavir can be explained by novel resistance pathways with protease mutation 76V

Author

Nijhuis, Monique, Wensing, Annemarie M.J., Bierman, Wouter F.W., de Jong, Dorien, Kagan, Ron, Fun, Axel, Jaspers, Christian A.J.J., Schurink, Karin A.M., van Agtmael, Michael A., and Boucher, Charles A.B.

Subjects
Gene mutations -- Research, Gene mutations -- Physiological aspects, Ritonavir -- Dosage and administration, Ritonavir -- Health aspects, Proteases -- Research, Proteases -- Physiological aspects, Drug resistance -- Research, HIV (Viruses) -- Drug therapy, Health
Published
2009

42. Persistence of HIV-1 variants with multiple protease inhibitor (PI) - resistance mutations in the absence of PI therapy can be explained by compensatory fixation

Author

van Maarseveen, Noortje M., Wensing, Annemarie M.J., de Jong, Dorien, Taconis, Maaike, Borleffs, Jan C.C., Boucher, Charles A.B., and Nijhuis, Monique

Subjects
HIV (Viruses) -- Research, HIV (Viruses) -- Physiological aspects, HIV (Viruses) -- Care and treatment, Protease inhibitors -- Research, Protease inhibitors -- Physiological aspects, Gene mutations -- Research, Health
Published
2007

43. Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Author

MMB Zorg, Infection & Immunity, MMB Research line 3b, MMB opleiding Arts microbioloog, MMB, dLAB Biobank, CTI, CTI Borghans, Divisieleiding, CTI CFF, MMB Research line 3a, Connell, Bridgette J., Hermans, Lucas E., Wensing, Annemarie M.J., Schellens, Ingrid, Schipper, Pauline J., van Ham, Petra M., de Jong, Dorien T.C.M., Otto, Sigrid, Mathe, Tholakele, Moraba, Robert, Borghans, José A.M., Papathanasopoulos, Maria A., Kruize, Zita, Venter, Francois W.D., Kootstra, Neeltje A., Tempelman, Hugo, Tesselaar, Kiki, Nijhuis, Monique, MMB Zorg, Infection & Immunity, MMB Research line 3b, MMB opleiding Arts microbioloog, MMB, dLAB Biobank, CTI, CTI Borghans, Divisieleiding, CTI CFF, MMB Research line 3a, Connell, Bridgette J., Hermans, Lucas E., Wensing, Annemarie M.J., Schellens, Ingrid, Schipper, Pauline J., van Ham, Petra M., de Jong, Dorien T.C.M., Otto, Sigrid, Mathe, Tholakele, Moraba, Robert, Borghans, José A.M., Papathanasopoulos, Maria A., Kruize, Zita, Venter, Francois W.D., Kootstra, Neeltje A., Tempelman, Hugo, Tesselaar, Kiki, and Nijhuis, Monique

Published
2020

44. Drug level testing as a strategy to determine eligibility for drug resistance testing after failure of ART: a retrospective analysis of South African adult patients on second-line ART

Author

MMB Research line 3b, MMB Staf diagnostiek, Infection & Immunity, Divisieleiding, dLAB Biobank, Apotheek Klinische Farmacie, MMB Research line 3a, MMB opleiding Arts microbioloog, Hermans, Lucas E., Steegen, Kim, ter Heine, Rob, Schuurman, Rob, Tempelman, Hugo A., Moraba, Robert, van Maarseveen, Erik, Nijhuis, Monique, Pillay, Taryn, Legg-E’Silva, Derryn, Snyman, Tracy, Schapiro, Jonathan M., Burger, David M., Carmona, Sergio, Wensing, Annemarie M.J., MMB Research line 3b, MMB Staf diagnostiek, Infection & Immunity, Divisieleiding, dLAB Biobank, Apotheek Klinische Farmacie, MMB Research line 3a, MMB opleiding Arts microbioloog, Hermans, Lucas E., Steegen, Kim, ter Heine, Rob, Schuurman, Rob, Tempelman, Hugo A., Moraba, Robert, van Maarseveen, Erik, Nijhuis, Monique, Pillay, Taryn, Legg-E’Silva, Derryn, Snyman, Tracy, Schapiro, Jonathan M., Burger, David M., Carmona, Sergio, and Wensing, Annemarie M.J.

Published
2020

45. An inkjet-printed polysaccharide matrix for on-chip sample preparation in point-of-care cell counting chambers

Author

MMB Zorg, Infection & Immunity, MMB, CDL unit Celdiagnostiek, CDL Patiëntenzorg MI, MMB Research line 3a, MMB opleiding Arts microbioloog, Zhang, Xichen, Wasserberg, Dorothee, Breukers, Christian, Connell, Bridgette J., Schipper, Pauline J., van Dalum, Joost, Baeten, Ellen, van den Blink, Dorine, Bloem, Andries C., Nijhuis, Monique, Wensing, Annemarie M.J., Terstappen, Leon W.M.M., Beck, Markus, MMB Zorg, Infection & Immunity, MMB, CDL unit Celdiagnostiek, CDL Patiëntenzorg MI, MMB Research line 3a, MMB opleiding Arts microbioloog, Zhang, Xichen, Wasserberg, Dorothee, Breukers, Christian, Connell, Bridgette J., Schipper, Pauline J., van Dalum, Joost, Baeten, Ellen, van den Blink, Dorine, Bloem, Andries C., Nijhuis, Monique, Wensing, Annemarie M.J., Terstappen, Leon W.M.M., and Beck, Markus

Published
2020

46. Risk factors for loss to follow-up from antiretroviral therapy programmes in low-income and middle-income countries

Author

Researchgr. Hart-brein as., MMB Research line 3b, MMB Zorg, MMB opleiding Arts microbioloog, Infection & Immunity, Global Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Divisieleiding, Frijters, Elise M., Hermans, Lucas E., Wensing, Annemarie M.J., Devillé, Walter L.J.M., Tempelman, Hugo A., De Wit, John B.F., Researchgr. Hart-brein as., MMB Research line 3b, MMB Zorg, MMB opleiding Arts microbioloog, Infection & Immunity, Global Health, Circulatory Health, JC onderzoeksprogramma Methodologie, Divisieleiding, Frijters, Elise M., Hermans, Lucas E., Wensing, Annemarie M.J., Devillé, Walter L.J.M., Tempelman, Hugo A., and De Wit, John B.F.

Published
2020

48. Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management

Author

Wensing, Annemarie M.J., van de Vijver, David A., Angarano, Gioacchino, Asjo, Birgitta, Balotta, Claudia, Boeri, Enzo, Camacho, Ricardo, Chaix, Maire-Laure, Costagliola, Dominique, De Luca, Andrea, Derdelinckx, Inge, Grossman, Zehava, Hamouda, Osamah, Hatzakis, Angelos, Hemmer, Robert, Hoepelman, Andy, Horban, Andrzej, Korn, Klaus, Kucherer, Claudia, Leitner, Thomas, Loveday, Clive, MacRae, Eilidh, Maljkovic, Irina, de Mendoza, Carmen, Meyer, Laurence, Nielsen, Claus, Op de Coul, Eline L., Ormaasen, Vidar, Paraskevis, Dimitris, Perrin, Luc, Puchhammer-Stockl, Elisabeth, Ruiz, Lidia, Salminen, Mika, Schmit, Jean-Claude, Schneider, Francois, Schuurman, Rob, Soriano, Vincent, Stanczak, Grzegorz, Stanojevic, Maja, Vandamme, Anne-Mieke, Van Laethem, Kristel, Violin, Michela, Wilbe, Karin, Yerly, Sabine, Zazzi, Maurizio, and Boucher, Charles A.

Subjects
Europe -- Health aspects, HIV infection -- Risk factors, HIV infection -- Drug therapy, Health
Published
2005

49. REtrieval And cure of Chronic Hepatitis C (REACH) : Results of micro-elimination in the Utrecht province

Author

Kracht, Patricia A.M., Arends, Joop E., van Erpecum, Karel J., Thijsen, Steven F.T., Vlaminckx, Bart J.M., Weersink, Annemarie J.L., Wensing, Anne M.J., Deege, Marjolein P.H., Dimmendaal, Marieke, Stadhouders, Paul H.G.M., Friederich, Philip W., Verhagen, Marc A.M.T., Boland, Greet J., Hoepelman, Andy I.M., Kracht, Patricia A.M., Arends, Joop E., van Erpecum, Karel J., Thijsen, Steven F.T., Vlaminckx, Bart J.M., Weersink, Annemarie J.L., Wensing, Anne M.J., Deege, Marjolein P.H., Dimmendaal, Marieke, Stadhouders, Paul H.G.M., Friederich, Philip W., Verhagen, Marc A.M.T., Boland, Greet J., and Hoepelman, Andy I.M.

Published
2019

50. Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells

Author

Verheyen, Jens, Thielen, Alexander, Lübke, Nadine, Dirks, Miriam, Widera, Marek, Dittmer, Ulf, Kordelas, Lambros, Däumer, Martin, De Jong, Dorien C.M., Wensing, Annemarie M.J., Kaiser, Rolf, Nijhuis, Monique, Esser, Stefan, Verheyen, Jens, Thielen, Alexander, Lübke, Nadine, Dirks, Miriam, Widera, Marek, Dittmer, Ulf, Kordelas, Lambros, Däumer, Martin, De Jong, Dorien C.M., Wensing, Annemarie M.J., Kaiser, Rolf, Nijhuis, Monique, and Esser, Stefan

Published
2019

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