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1. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH 2 Lead to Potent and Selective Agonists at hMC1R and hMC4R.

2. MC4R biased signalling and the conformational basis of biological function selections.

3. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.

4. C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters.

5. Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions.

6. Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism.

7. Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.

8. Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.

9. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice.

10. Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands.

11. Development of N -Acetylated Dipalmitoyl- S -Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists.

12. Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction.

14. Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice.

15. Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors.

16. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH 2 , leads to hMC1R selectivity and pigmentation.

17. Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

18. Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence.

19. Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation.

20. Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.

21. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.

22. Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics.

23. Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers.

24. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.

25. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain.

26. Structure-Activity Relationships of [des-Arg 7 ]Dynorphin A Analogues at the κ Opioid Receptor.

27. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors.

28. Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors.

29. Design of cyclized selective melanotropins.

30. Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors.

31. Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5.

32. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands.

33. Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment.

34. Dynorphin A analogs for the treatment of chronic neuropathic pain.

35. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.

36. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases.

37. Cyclic Opioid Peptides.

38. Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.

39. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.

40. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.

41. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors.

42. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands.

43. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities.

44. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors.

45. Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs.

46. Cancer vaccine adjuvants--recent clinical progress and future perspectives.

47. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors.

48. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors.

49. Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist.

50. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor.

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