1. Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review
- Author
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Karolina Wojtunik-Kulesza, Tomasz Oniszczuk, Jarosław Mołdoch, Iwona Kowalska, Jarosław Szponar, and Anna Oniszczuk
- Subjects
Biological Products ,QH301-705.5 ,Organic Chemistry ,neurodegeneration ,General Medicine ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Chemistry ,Neuroprotective Agents ,Alzheimer Disease ,Animals ,Humans ,Physical and Theoretical Chemistry ,Biology (General) ,Molecular Biology ,Alzheimer’s disease ,QD1-999 ,Spectroscopy ,polyphenols ,terpenes ,secondary plant metabolites ,dementia - Abstract
Neurodegenerative disorders such as Alzheimer’s disease (AD) are distinguished by the irreversible degeneration of central nervous system function and structure. AD is characterized by several different neuropathologies—among others, it interferes with neuropsychiatrical controls and cognitive functions. This disease is the number one neurodegenerative disorder; however, its treatment options are few and, unfortunately, ineffective. In the new strategies devised for AD prevention and treatment, the application of plant-based natural products is especially popular due to lesser side effects associated with their taking. Moreover, their neuroprotective activities target different pathological mechanisms. The current review presents the anti-AD properties of several natural plant substances. The paper throws light on products under in vitro and in vivo trials and compiles information on their mechanism of actions. Knowledge of the properties of such plant compounds and their combinations will surely lead to discovering new potent medicines for the treatment of AD with lesser side effects than the currently available pharmacological proceedings.
- Published
- 2022