Search

A recent study conducted at the University of Gondar in Ethiopia has found that pretreatment with lidocaine can significantly reduce the occurrence of postoperative myalgia caused by the muscle relaxant succinylcholine. The study involved 208 adult surgical patients and found that patients exposed to lidocaine had a lower incidence of myalgia compared to those who were not exposed. The study also identified other factors, such as the use of multimodal analgesia and non-steroidal anti-inflammatory drugs, as well as postoperative immobility and being male, that can help reduce succinylcholine-induced myalgia. This research provides valuable insights into preventive mechanisms for postoperative myalgia and highlights potential strategies for managing this condition. [Extracted from the article]

A retrospective study conducted by researchers at Shanxi Medical University in China compared the efficacy and adverse effects of oral ferrous succinate tablets and intravenous iron sucrose for the treatment of iron deficiency anemia. The study included 374 patients and found that both treatment groups showed improvements in hemoglobin, serum iron, serum ferritin, and mean corpuscular volume after four weeks of treatment. However, the group receiving intravenous iron sucrose had higher levels of these markers compared to the group receiving oral ferrous succinate tablets. The study concluded that iron sucrose is an effective and safe treatment for iron deficiency anemia. [Extracted from the article]

Researchers from South China Agricultural University have conducted a study on the immunomodulatory activity of Caulerpa chemnitzia polysaccharides (CRVP) in macrophages. The study found that CRVP promotes cell proliferation, upregulates cytokine expression, and increases levels of nitric oxide and reactive oxygen species. The researchers also discovered that succinic acid plays a key role in the immunomodulatory effects of CRVP by regulating the expression of prolyl hydroxylase domain 2 (PHD2) and hypoxia-inducible factor-1 alpha (HIF1 alpha), thereby enhancing IL-1(3 expression. The study concludes that CRVP exerts its immunomodulatory activity in macrophages through the succinate/PHD2/HIF-1 alpha/IL-1(3 pathway. [Extracted from the article]

A recent study conducted at NewYork-Presbyterian Brooklyn Methodist Hospital compared the success rates of two neuromuscular blocking agents, rocuronium and succinylcholine, for rapid sequence intubation in the emergency department. Previous studies had suggested that rocuronium had lower success rates compared to succinylcholine. However, this retrospective study found no significant difference in first-attempt intubation success between the two agents. The study suggests that further research is needed to evaluate the impact of weight-based dosing on intubation success. [Extracted from the article]

A recent study conducted at Cairo University in Egypt has developed a new method for quantifying the antidepressant desvenlafaxine succinate (ODV) using a glassy carbon electrode (GCE) and multi-walled carbon nanotubes (MWCNTs). The electrode demonstrated a wide range of linearity and a low detection limit, making it an effective tool for quantifying ODV in various forms, including pure form, dosage form, and biological fluids such as urine and plasma. The researchers found that the method is environmentally friendly and cost-effective, making it suitable for use in quality control units, production units, hospitals, and clinical laboratories. The study has been peer-reviewed and published in the Microchemical Journal. [Extracted from the article]

A recent study conducted by researchers at Jamia Hamdard in New Delhi, India, has developed a new approach to targeting HIV-1 viral reservoirs using a combination of drugs. The researchers formulated a nanostructured lipid carrier decorated with D-alpha-tocopheryl polyethylene glycol succinate (TPGS) and loaded it with Etravirine (ETR) and Darunavir Ethanolate (DRVE). In vitro studies showed that this formulation was effective in inhibiting HIV-1 infection. The optimized lipid nanosystem also demonstrated improved drug release and enhanced oral bioavailability. These findings have the potential to reduce the side effects of high doses of antiretroviral drugs. [Extracted from the article]

A recent report from Okayama University in Japan discusses new research on chemicals and chemistry related to bone research. The study focuses on the synthesis and structural characterization of Sr2+-containing octacalcium phosphate (OCP) samples incorporated with 2,6-pyridinedicarboxylate (PA) ions and succinate (SA) ions. The researchers found that the SrOCPC sample at a PA/(PA+SA) molar ratio of 0.01 has the potential to be a novel bone defect filler with multiple drug loading capability. This research was funded by Grants-in-Aid for Scientific Research (KAKENHI), Okayama Foundation for Science and Technology, and Iketani Science and Technology Foundation. [Extracted from the article]

Researchers at the Institute for Pharmaceutical Sciences in Andhra Pradesh, India, have developed a new formulation of Valsartan, an angiotensin II inhibitor used in cardiovascular therapy. The study aimed to enhance the dissolution rate of Valsartan by forming complexes with beta-Cyclodextrin. The researchers successfully formulated fast-dissolving tablets of Valsartan using primojel and starch succinate as a novel super disintegrant. The optimized tablet demonstrated a disintegration time of only 15 seconds and an impressive 85.69% dissolution within 10 minutes. This research has been peer-reviewed and provides valuable insights into the development of Valsartan tablets. [Extracted from the article]

A patent application has been filed for an amorphous form of pretomanid, a nitroimidazole anti-bacterial agent used in the treatment of tuberculosis (TB). Pretomanid has shown promising characteristics as a TB therapy, including activity against drug-resistant strains and a lack of mutagenicity. The invention aims to improve the solubility of pretomanid, potentially enhancing its effectiveness as a treatment. The patent application includes details of the amorphous form of pretomanid, pharmaceutical compositions, and methods of treatment. [Extracted from the article]

A recent study conducted at Ashikaga Red Cross Hospital has reported a case of potentially lethal malignant hyperthermia following electroconvulsive therapy (ECT) in a 79-year-old woman. Malignant hyperthermia is a life-threatening condition triggered by certain anesthetic drugs, particularly succinylcholine. This case highlights the delayed onset of malignant hyperthermia after ECT and emphasizes the importance of psychiatrists recognizing its symptoms and promptly treating it with dantrolene. The study underscores the need for close monitoring of patients' vital signs during and after ECT to prevent potentially lethal consequences. [Extracted from the article]

A research study conducted by Hunan University of Chinese Medicine explores the role of succinate in inflammation. Succinate, previously considered a byproduct of the tricarboxylic acid cycle, has been found to play a crucial role in inflammation. Excess succinate in the cytosol stabilizes hypoxia-inducible factor-1a, leading to enhanced inflammatory responses. Succinate also acts as a signaling molecule, modulating immune cell activities. The study suggests that targeting succinate pathways could offer potential therapeutic avenues for inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, obesity, and atherosclerosis. [Extracted from the article]

A report from Central Washington University discusses research on the synthesis of allylic 2-oxopyrrolidines, which are important components of certain pharmaceuticals. The researchers describe a flexible annulation strategy that combines succinic anhydride and 1,3-azadienes to produce these compounds. The approach is chemoselective, efficient, modular, scalable, and diastereoselective, allowing for post-diversification and the incorporation of motifs with pharmaceutical value. The research concludes that this strategy is a flexible and effective method for producing allylic 2-pyrrolidinones with contiguous stereocenters. [Extracted from the article]

A patent application by Bayer Healthcare LLC has been made available online for a high concentration suspension formulation for cold and flu soft gel capsule medications. The invention aims to provide smaller dosage forms of these medications, which are more convenient and pleasant for consumers to take. The soft gel capsules contain a suspension with specific amounts of acetaminophen, dextromethorphan HBr, phenylephrine HCl, and optional additional active pharmaceutical ingredients. The method for preparing the soft gel capsules involves combining various ingredients and encapsulating the suspension with an outer shell mixture. [Extracted from the article]

A recent report from the University Clinical Center of Serbia discusses the findings of a study on leiomyomas, a type of tumor. The study focuses on two cases of uterine leiomyomas that exhibit rare histomorphological and genetic characteristics. These characteristics are important for prognosis and further treatment. The study emphasizes the need for careful examination and follow-up due to the predictive significance of these features, which can indicate additional hereditary cancer syndromes. [Extracted from the article]

A recent study conducted at Brigham and Women's Hospital in Boston, Massachusetts, has found that a specific microRNA, miR-369-3p, may have therapeutic potential in treating diabetes-associated atherosclerosis. The researchers discovered that miR-369-3p expression was significantly lower in aortic intimal lesions from mice on a high-fat sucrose diet and in peripheral blood mononuclear cells from diabetic patients with coronary artery disease. In vitro experiments showed that miR-369-3p overexpression reduced inflammation and metabolic alterations in macrophages. Therapeutic administration of miR-369-3p mimics in mice reduced atherosclerosis and inflammation. The study suggests that miR-369-3p may regulate macrophage succinate metabolism and could be a potential target for treating diabetes-associated atherosclerosis. [Extracted from the article]

A study conducted by researchers at the South China University of Technology explores the enzymatic synthesis of vitamin E succinate, a potential therapeutic agent for cancer treatment. The study focuses on the challenges associated with optimizing and scaling up the production of vitamin E succinate using lipases, particularly their poor stability in organic solvents. The researchers compare Lipase UM1 with three other immobilized commercial lipases and find that Lipase UM1 demonstrates enhanced resistance to organic solvents and superior efficiency in vitamin E succinate production. The study concludes that Lipase UM1 is a promising catalyst for industrial production of vitamin E succinate, with potential applications in cancer therapy. [Extracted from the article]

A recent study conducted at the University of Madras in Chennai, India, has yielded new findings on optoelectronics and nanotechnology. The researchers successfully synthesized and grew an organic nonlinear optical single crystal called 4-Hydroxypyridinium Succinate using the slow evaporation method. The crystal was found to have an orthorhombic structure and high transparency in the UV visible region. It also exhibited violet emission properties and belonged to the soft material category with reasonable hardness parameters. The crystal showed thermally stability up to 188°C and had a laser-induced damage threshold of 21.93 Gw/cm2. The study concluded that the crystal demonstrated second harmonic generation efficiency. [Extracted from the article]

A patent application titled "Diagnosis And Treatment Of Autism Spectrum Disorders Using Altered Ratios Of Metabolic Concentrations" is currently being reviewed by the US Patent and Trademark Office. The inventors propose a method for diagnosing and treating autism spectrum disorders (ASD) by analyzing metabolic pathways. The goal is to identify specific metabolic defects associated with ASD, enabling early detection and personalized interventions. The method involves measuring concentrations of metabolites and analyzing their ratios to identify imbalances and specific metabolic pathways. The patent application provides a comprehensive list of metabolites and their corresponding ratios that can be used in the analysis. [Extracted from the article]

A recent study conducted at Tianjin Medical University General Hospital in China has provided new insights into glioblastomas, a type of cancer. The research focused on the role of hypoxia, or oxygen deprivation, in glioblastoma development and the post-translational modification of oncogenic proteins. The study found that the HIF1 alpha and ATF3 proteins regulate the transcription of P4HA1, leading to increased succinate production and activation of HIF1 alpha signaling. This pathway may serve as a potential target for treating glioblastomas. The study was peer-reviewed and published in the journal Neuro-Oncology. [Extracted from the article]

A recent report from researchers at the National Institute of Pharmaceutical Education and Research in Telangana, India, discusses the development of raloxifene loaded nanoparticles for the treatment of breast cancer. Raloxifene is a selective estrogen receptor modulator that has shown promise in treating uterine and breast cancer. However, it has limitations in terms of low water solubility, extensive gut metabolism, and poor oral bioavailability. The researchers developed nanoparticles to offer sustained release through a parenteral route of administration. The nanoparticles demonstrated successful internalization in breast cancer cells and showed anti-proliferative activity. Further investigation is needed to determine the clinical viability of this approach. [Extracted from the article]

A study conducted by researchers at the University of Novi Sad in Serbia focused on the electrochemical behavior of solifenacin succinate (SOL), a drug commonly used for the treatment of urinary incontinence and urinary frequency. The study aimed to develop reliable and effective electrochemical sensors for SOL. The researchers tested three different working electrodes (gold, glassy carbon, and boron-doped diamond) and found that the SOL oxidation process is irreversible and diffusion-controlled. They also developed a differential pulse voltammetric (DPV) method for the electroanalytical determination of SOL, which showed excellent recovery and reproducibility. The study concluded that the boron-doped diamond electrode with the optimized DPV method could be used for trace-level electroanalytical determination of SOL in human urine samples. [Extracted from the article]

Researchers from Wuhan Polytechnic University have conducted a study on the treatment of neuroinflammation-based brain diseases. They developed multifunctional nanoparticles using octenyl succinic anhydride (OSA)-modified starch to carry selenium (Se) and folic acid (FA). These nanoparticles, called FA-OSAS-SeNPs, were found to ameliorate spatial learning and memory impairment caused by lipopolysaccharide (LPS)-induced inflammation. They also suppressed glial cell activation and the release of inflammatory factors, alleviated endoplasmic reticulum (ER) stress, and inhibited the overactivation of signaling pathways associated with inflammation. The researchers concluded that FA-OSAS-SeNPs show promise as an alternative or supplementary treatment for inflammatory brain diseases. [Extracted from the article]

A study conducted by researchers at Jagiellonian University in Krakow, Poland, explores the potential use of Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti-ischemic metabolic modulators, and ergogenic aids in athletes. Mexidol, a synthetic derivative of vitamin B6, has been used by Russian athletes in the past and exhibits similar effects to drugs on the World Anti-Doping Agency (WADA) Prohibited List. The study suggests that combinations of these substances with succinate can enhance athletic performance. However, the researchers note that the line between performance enhancement and therapeutic drugs is becoming increasingly blurred, making it difficult to determine when a substance becomes a doping agent. [Extracted from the article]

A study conducted at Bharathidasan University in Kumbakonam, India, focused on the synthesis and analysis of a new organic crystal called 4-methylbenzylammonium hydrogen succinate (4MLBAHS). The researchers determined the crystal's structure and identified its space group. They also conducted various analyses, including vibrational analysis, UV-Vis-NIR analysis, and nuclear magnetic resonance spectroscopy, to understand the crystal's properties. The study found that the crystal exhibited third-order nonlinear optical characteristics, which were enhanced by the presence of hydrogen bond interactions. The research was supported by the Instrumentation Centre of St. Joseph's College and has been peer-reviewed. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital explored the effect of oncometabolite succinate on colorectal cancer migration and invasion. The researchers found that succinate levels were significantly higher in carcinoma tissues compared to paracancerous tissues. Succinate treatment enhanced the migration and invasion of colorectal cancer cells and promoted the epithelial-mesenchymal transition (EMT) process. The study concluded that succinate promotes EMT through the activation of the transcription factor STAT3, thereby promoting the migration and invasion of colorectal cancer. [Extracted from the article]

Researchers at the University of Karachi in Pakistan have developed a new formulation of sumatriptan succinate orodispersible tablets for immediate relief of migraines. The study used chitosan and sodium starch glycolate as independent variables and measured factors such as friability, disintegration, dispersion time, and water absorption ratio. The trial formulations showed good micromeritic properties and had excellent dissolution rates. The research concluded that both chitosan and sodium starch glycolate can be used together to create an effective orodispersible formulation of sumatriptan succinate. [Extracted from the article]

Researchers at Federal University Sao Paulo have developed and optimized a stability-indicating method for solifenacin succinate and its main degradation product using high-performance liquid chromatography. The study involved a forced degradation study to evaluate the potential degradation profile of solifenacin succinate. The researchers also optimized the extraction procedure and developed a chromatographic method for analysis. The developed method was applied to evaluate the degradation profile of commercially purchased drugs. This research provides valuable insights for the development and analysis of genitourinary tract agents. [Extracted from the article]

A patent has been issued for compositions of a compound called 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoropheyl)-3-phenylurea. The patent was filed by inventors from Deciphera Pharmaceuticals LLC and published online on March 5, 2024. The compound is a c-KIT inhibitor and has potential therapeutic value in the treatment of gastrointestinal stromal tumors (GIST) and other disorders. The patent describes pharmaceutical compositions containing the compound and one or more pharmaceutically acceptable carriers, excipients, or diluents. The compositions aim to provide stable oral formulations with good therapeutic properties. [Extracted from the article]

Researchers from the College of Pharmacy in Baghdad, Iraq have conducted a study on the delivery of frovatriptan succinate, a central nervous system agent, through intranasal administration. The study aimed to assess the efficacy of a novel intranasal gel formulation in targeting the brain. The results showed that the intranasal formulation led to significantly higher concentrations of frovatriptan succinate in the brain compared to intravenous administration. The researchers concluded that the intranasal gel formulation could improve patient adherence due to its convenience and reduced frequency of administration. [Extracted from the article]

A patent application has been filed for a potential treatment for idiopathic pulmonary fibrosis (IPF), a chronic lung disease characterized by excessive deposition of extracellular matrix in the lungs. The inventors have identified a pathway that limits fibrosis in the lungs and have shown that a bioactive metabolite called itaconate can impair fibroblast activity and improve lung fibrosis in mice. The invention includes an agent that inhibits succinate dehydrogenase, which can be administered through inhalation or other methods, and a population of monocyte-recruited macrophages for the treatment or prevention of tissue fibrosis. The treatment aims to improve lung function, reduce fibrosis progression, and enhance quality of life for individuals with pulmonary fibrosis. [Extracted from the article]

Researchers at Voronezh State University in Russia have conducted a study on the use of chitosan and chitosan succinate as photoprotectors for papain immobilized on their matrix. The study found that adsorption immobilization on these matrices increased the stability of papain molecules against UV irradiation. The researchers suggest that these findings could be useful in the development of drugs for accelerated skin healing and in determining conditions for UV sterilization of drugs containing papain. The research has been peer-reviewed and published in the Biology Bulletin. [Extracted from the article]

Researchers at Islamia University Bahawalpur in Punjab, Pakistan have conducted a study on the synthesis and characterization of Tocopherol Succinate-loaded Ethosomal Gel (TSEG) for application on human skin. Tocopherol succinate is a well-known antioxidant and moisturizing agent commonly used in skincare products. The researchers used a cold method technique to prepare the TSEG and conducted various physical characterizations and stability studies. The results showed that the developed TSEG formulation was efficient, safe, stable for at least 3 months, and improved skin complexation and integrity. The study provides valuable insights for the development of skincare products. [Extracted from the article]

A recent study conducted by Weill Cornell Medicine examined the clinical significance of succinate dehydrogenase (SDH) mutations in head and neck paragangliomas (HNPs). The study analyzed data from 42 studies involving 8,849 patients and found a correlation between SDH mutations and certain characteristics of HNPs. Specifically, the study found that multifocality of HNPs was associated with the SDHD mutational subtype, while distant metastases were associated with the SDHB subtype. The researchers concluded that understanding these associations could potentially impact the management of HNPs. [Extracted from the article]

Researchers from Virginia Commonwealth University have developed a practical and scalable synthesis process for the production of succinylcholine chloride, a neuromuscular blocking agent used in medicine. The process utilizes readily available starting materials and avoids the need for a recrystallization step. The researchers were able to achieve an average yield of 89% and meet the quality specifications for the active pharmaceutical ingredient. This research was supported by Phlow Corporation and has been peer-reviewed. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of succinate, a metabolite produced by the intestinal microbiota, in modulating tuft cell dynamics in the large intestine and its relevance to Clostridioides difficile infection. The study reveals a three-way circuit between commensal microbes, C. difficile, and host epithelial cells centered around succinate. Through experiments with selective microbiota depletion and rational supplementation, the researchers demonstrate that succinate plays a causal role in modulating colonic tuft cell abundance and type 2 cytokine induction. The findings suggest that activation of tuft cells by microbiota-produced succinate in the colon is a mechanism evolved by the host to counterbalance cues that facilitate invasion by intestinal pathogens. [Extracted from the article]

A study conducted by researchers from the College of Medicine and Sagore Dutta Hospital in West Bengal, India, compared the intubating conditions achieved by different doses of rocuronium bromide and succinylcholine chloride. The study found that rocuronium bromide can be used as an alternative to succinylcholine as an ideal intubating muscle relaxing agent for long surgeries. The researchers concluded that a dose of 0.9 mg/kg of rocuronium bromide produced similar intubating conditions as 1 mg/kg of succinylcholine chloride without prolonging the neuromuscular blockade. This information may be useful for medical professionals seeking alternatives to succinylcholine for intubation. [Extracted from the article]

Researchers from the Department of Pharmaceutics have conducted a study on the treatment of colon cancer using polymeric nanoparticles. The study focused on the preparation of Enzalutamide-loaded nanoparticles coated with polysarcosine and d-a-Tocopheryl polyethylene glycol 1000 succinate (TPGS). The researchers found that the nanoparticles exhibited nanosized, spherical characteristics with high drug entrapment efficiency. In vitro and in vivo assessments showed low toxicity and high efficacy of the nanoparticles compared to the drug alone. The study suggests that these nanoparticles could be a promising and safe delivery system for colorectal cancer treatment. [Extracted from the article]

A patent application by inventors from the Wisconsin Alumni Research Foundation has been made available online. The invention relates to methods of improving cardiac structure and/or function in a subject by administering a succinate dehydrogenase inhibitor. The methods can be used to treat myocardial lesions, such as fibrosis or myocardial infarction, and can be administered after a cardiac event, such as ischemia or ischemia-reperfusion. The succinate dehydrogenase inhibitor can be administered over a period of time and has the potential to improve cardiac function and structure. [Extracted from the article]

A study conducted at the University of Palermo in Italy explores the use of electrosprayed poly-butyl-succinate microparticles as a drug delivery system for ciprofloxacin, an antibiotic used to treat bacterial infections. The microparticles, made from a biodegradable and biocompatible polyester, demonstrated sustained release of ciprofloxacin for several days and effectively inhibited the growth of bacteria commonly involved in chronic wound healing. The study suggests that this innovative drug delivery system has the potential to improve the efficacy of antibiotics and enhance patients' quality of life. The research was supported by the Ministry of Education, Universities and Research (MIUR). [Extracted from the article]

A recent study conducted by researchers at the Scripps Research Institute has identified the energetic reactions in brain cells that malfunction and lead to neurodegeneration in Alzheimer's disease. By using a small molecule to address the malfunction in the mitochondria, the researchers were able to restore many neuron-to-neuron connections in nerve cell models derived from human Alzheimer's patient stem cells. The study found that a block in the enzymes that make energy, caused by an abnormal tag of nitrogen and oxygen atoms onto a sulfur atom, led to a disruption in the Krebs cycle, which produces ATP, the body's molecular power source. The researchers were able to restore energy production by supplying missing succinate molecules, repairing up to three quarters of the lost synapses. However, further research is needed to develop a safe and effective drug for humans. [Extracted from the article]

A patent has been issued for articles made from poly(butylene succinate) (PBS) and copolymers thereof. These implants are biocompatible, have high tensile strength, and prolonged strength retention. They are suitable for use in various medical procedures such as hernia repair, soft tissue reinforcement, breast reconstruction, orthopedic repairs, wound management, and more. The implants are made without the use of crosslinking agents that can release toxic metabolites, and they degrade into non-toxic degradation products. The patent describes methods for forming the implants, including melt processing and 3D printing. [Extracted from the article]

A study conducted at Second Xiangya Hospital in Hunan, China, aimed to evaluate and compare the pharmacokinetic profiles and establish bioequivalence of two metoprolol succinate extended-release (ER) tablets in healthy Chinese subjects under fasting and fed conditions. The study found that both formulations of the medication were well-tolerated by all participants, with no significant differences in adverse events reported between the two groups. The test metoprolol ER tablet was determined to be bioequivalent to the reference metoprolol ER tablet in healthy Chinese subjects under both fasting and fed conditions. The research was funded by Guangxi Houde Health Industry Co. Ltd. and the National Science and Technology Major Projects for Major New Drugs Innovation and Development. [Extracted from the article]

Researchers from Tampere University in Finland have conducted a study on the hydrolytic degradation of polylactide/polybutylene succinate blends with bioactive glass. The study aimed to understand the impact of blending and compounding with bioactive glass on the mechanical properties and degradation of the materials. The researchers found that blending and compounding with bioactive glass allowed for the production of materials with a wide range of mechanical properties, making them suitable for tissue engineering applications. The study was supported by the TUT Foundation and Business Finland. [Extracted from the article]

A new study conducted by researchers at China Agricultural University explores the relationship between succinate and obesity. The study found that supplementing obese mice with succinate led to a decrease in adipose tissue, triglyceride contents, and NEFA levels. Additionally, succinate enhanced lipolysis in adipose tissue and stimulated the activity of BAT. However, the study concluded that while succinate may have a beneficial effect on obesity pathogenesis, it did not efficiently decrease body weight. Further research is needed to fully understand the potential of succinate in obesity interventions. [Extracted from the article]