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A 23-year-old man developed oesophagitis with an oesophageal ulcer while being treated with doxycycline for rosacea. He experienced symptoms such as precordial pain, retrosternal knotting sensation, and sudden-onset dysphagia on solids, leading to a hospital visit. An urgent eosophagogastroduodenoscopy revealed a superficial oesophageal ulcer with fibrin, and the diagnosis confirmed drug-induced oesophagitis. Treatment with omeprazole was initiated, doxycycline was discontinued, and the man recovered after one month with no further medical intervention. [Extracted from the article]

In a retrospective study of 13 children with macrocystic and mixed cystic lymphatic malformation, two cases were reported of adverse reactions to doxycycline treatment. One child experienced vomiting, while another had intracystic hemorrhage. The vomiting resolved on its own, and the intracystic hemorrhage improved after receiving treatment for hemostasis. The specific details of the treatment, such as dosage and duration, were not provided in the study. [Extracted from the article]

A case report in the journal Reactions Weekly describes a 59-year-old man who experienced a lack of efficacy during treatment for disseminated neurobrucellosis. The man presented with symptoms such as hoarseness of voice, dysphagia, hearing loss, and paraparesis. He was treated with doxycycline, rifampicin, and ceftriaxone, but unfortunately, he did not respond to the treatment and ultimately passed away. This case highlights the challenges in treating disseminated neurobrucellosis and the need for further research in this area. [Extracted from the article]

In a case series, two adolescent girls developed acneiform eruptions while being treated with trametinib. They also experienced a rebound of the rash when they were given doxycycline for the eruptions, and xerosis when they were given isotretinoin for the eruptions. The girls required a reduction in the dose of isotretinoin, but overall the therapy was well tolerated. One girl's acneiform rash improved, while the other girl's rash became ungradable with only residual pink papules. [Extracted from the article]

A retrospective study of 25 patients conducted between 2015-2023 reported a case of lack of efficacy of doxycycline in treating lymphatic malformation (LM). The patient, whose age and sex were not disclosed, underwent percutaneous sclerotherapy with doxycycline as a sclerosing agent, but the treatment was unsuccessful. This case highlights the ineffectiveness of doxycycline in this particular medical condition. [Extracted from the article]

A 41-year-old man with hidradenitis suppurativa (HS) and inverse psoriasis experienced a lack of efficacy with doxycycline and methylprednisolone treatments. Despite taking doxycycline, the patient developed new lesions, indicating that the medication was not effective. After being diagnosed with inverse psoriasis, the patient was prescribed methylprednisolone cream, but experienced a severe flare-up months later, suggesting that the medication was also ineffective. As a result, the patient was started on adalimumab and achieved remission. [Extracted from the article]

This article from Reactions Weekly presents a systematic literature review case study involving four children who developed drug-induced lupus erythematosus (DILE) while being treated with topiramate, doxycycline, etanercept, and ethosuximide. The exact ages of the children are not provided. In each case, the child discontinued the treatments and their symptoms completely resolved. The article does not provide information on the indications, routes, dosages, or durations of the treatments in relation to the onset of the reactions. [Extracted from the article]

A 56-year-old man experienced bradycardia-tachycardia syndrome while being treated with isoprenaline for sinus pauses, and also showed lack of efficacy during treatment with ceftriaxone for lyme carditis. The man received intravenous ceftriaxone and subsequently developed multiple sinus pauses, leading to the administration of isoprenaline. However, this resulted in bradycardia-tachycardia syndrome. Despite 10 days of ceftriaxone treatment, the patient continued to experience intermittent sinus pauses, indicating a lack of effectiveness. He ultimately received a permanent pacemaker and was discharged on doxycycline, with further follow-up scheduled. [Extracted from the article]

A 21-year-old man with B-cell acute lymphoblastic leukemia and brucellosis exhibited lack of efficacy during treatment with doxycycline. He was admitted to the hospital with symptoms including dry cough, jaundice, fever, and haemoptysis. Despite receiving treatment with doxycycline, he died after three days. The article provides information about the patient's medical condition and the lack of effectiveness of doxycycline in his case. [Extracted from the article]

A 79-year-old woman with a history of coronary artery disease and cardiac arrest was admitted to the hospital for weakness, nausea, and vomiting. She had recently removed multiple ticks from her body and was diagnosed with Lyme disease and babesia coinfection. She was treated with doxycycline, azithromycin, and atovaquone, but experienced sudden dyspnea and chest tightness. She was transferred to the ICU, intubated, and diagnosed with stress-induced/Takotsubo cardiomyopathy with severe pulmonary hypertension. Despite resuscitation efforts, she ultimately died from fulminant myocarditis, indicating a lack of efficacy of the treatment. [Extracted from the article]

A 28-year-old woman experienced angioedema of the upper lip while being treated with doxycycline for pelvic inflammatory disease. She also developed angioedema of the eyelids due to cross-reactivity with minocycline. After discontinuing doxycycline and receiving treatment with levocetirizine, she recovered. Tests for doxycycline and minocycline allergies yielded negative results, but a rechallenge with doxycycline resulted in a recurrence of angioedema. A drug challenge test with minocycline also caused angioedema, indicating cross-reactivity. The association between doxycycline and angioedema was deemed probable. [Extracted from the article]

An 84-year-old man with a history of heart disease and other medical conditions was treated for Bartonella hensalae infective endocarditis with a combination of rifampicin, doxycycline, and gentamicin. However, his condition worsened and he experienced kidney failure, requiring dialysis. Despite switching to gentamicin and maintaining antibiotic treatment, there was no improvement. Due to the high surgical risk, he was not evaluated for surgical therapy. Unfortunately, he passed away from Bartonella hensalae infective endocarditis. [Extracted from the article]

A 40-year-old woman experienced an inflammatory reaction while being treated with ivermectin for demodicosis. After applying the ivermectin cream for the first time, she developed pustules and papules around her mouth and forehead. The reaction was determined to be a result of the ivermectin treatment and the medication was discontinued. The woman was then treated with doxycycline, prednisone, and chamomile, which resulted in rapid improvement and complete healing within 14 days. The woman later resumed ivermectin treatment without any recurrence of the lesions. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA multicenter, retrospective study of 17 patients with urinary tract infections (UTI) was performed between 1 September 2020 and 31 August 2022; a patient [age and sex not stated] was described, who developed syncope during treatment with oral doxycycline for UTI [dosage, duration of treatment to reaction onset and outcome not stated]. [Extracted from the article]

A 33-year-old man with bilateral uveitis or leptospirosis was treated with rituximab, prednisone, and doxycycline, but did not experience any improvement in symptoms. He later underwent autologous hematopoietic stem cell transplantation, during which he developed cloudy vision in his left eye, followed by similar symptoms in his right eye. Various tests were conducted to determine the cause of his symptoms, including serology testing, culture tests, and MRI scans, all of which came back negative. Eventually, DNA sequencing identified Leptospira santarosai in his aqueous fluid, confirming a diagnosis of leptospirosis. Treatment with oral doxycycline and an intravitreal dexamethasone implant led to an improvement in his vision and the resolution of uveitis symptoms. [Extracted from the article]

A 19-year-old woman with bipolar disorder developed acute eosinophilic pneumonia while being treated with paliperidone. She also exhibited a lack of efficacy when treated with doxycycline for the pneumonia. The woman, who was morbidly obese and had a history of anxiety, presented to the hospital with worsening respiratory symptoms. She was diagnosed with acute eosinophilic pneumonia secondary to paliperidone and was started on doxycycline, but her condition worsened and she required mechanical ventilation. After receiving dexamethasone and methylprednisolone treatment, her condition improved rapidly. [Extracted from the article]

A 52-year-old woman experienced idiopathic intracranial hypertension (IH) while being treated with isotretinoin for rosacea. She later had a recurrence of IH while taking doxycycline for the same condition. The woman initially presented with bilateral papilledema and severe headaches, and further tests revealed radiographic features of IH. Treatment with liquor drainage and acetazolamide led to improvement, but the IH recurred after the first lumbar puncture. A second episode occurred after starting doxycycline, but the woman experienced improvement after discontinuing the medication. [Extracted from the article]

A 55-year-old woman with Whipple's disease experienced a lack of efficacy during treatment with cotrimoxazole. She initially presented with weakness and diarrhea and was diagnosed with Whipple's disease. After receiving long-term antibiotic therapy with ceftriaxone and then cotrimoxazole, she experienced a recurrence of symptoms. The woman was then switched to second-line therapy with doxycycline and hydroxychloroquine, which led to clinical improvement. After one year of treatment, she showed no symptoms of Whipple's disease. [Extracted from the article]

A 40-year-old woman experienced an inflammatory reaction while being treated with ivermectin for demodicosis. After applying the ivermectin cream for the first time, she developed pustules and papules around her mouth and forehead. The reaction was determined to be a result of the ivermectin and the treatment was discontinued. The woman was then treated with doxycycline, prednisone, and chamomile, which resulted in rapid improvement and complete healing within 14 days. The woman later resumed treatment with ivermectin without any recurrence of the lesions. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA multicenter, retrospective study of 17 patients with urinary tract infections (UTI) was performed between 1 September 2020 and 31 August 2022; a patient [age and sex not stated] was described, who developed syncope during treatment with oral doxycycline for UTI [dosage, duration of treatment to reaction onset and outcome not stated]. [Extracted from the article]

A 33-year-old man with bilateral uveitis or leptospirosis was treated with rituximab, prednisone, and doxycycline, but did not experience any improvement in symptoms. He later underwent autologous hematopoietic stem cell transplantation, during which he developed cloudy vision in his left eye, followed by similar symptoms in his right eye. Various tests were conducted to determine the cause of his symptoms, including serology testing, culture tests, and MRI scans, but no definitive diagnosis was made. Eventually, DNA sequencing identified Leptospira santarosai in his aqueous fluid, confirming a diagnosis of leptospirosis. Treatment with oral doxycycline and an intravitreal dexamethasone implant resulted in improved vision and inactive uveitis. [Extracted from the article]

A 19-year-old woman with bipolar disorder developed acute eosinophilic pneumonia while being treated with paliperidone. She also exhibited a lack of efficacy when treated with doxycycline for the pneumonia. The woman had a history of anxiety and bipolar disorder and was morbidly obese. She was admitted to the hospital with respiratory symptoms and was diagnosed with acute eosinophilic pneumonia secondary to paliperidone. Treatment with doxycycline initially did not improve her condition, but after receiving dexamethasone and methylprednisolone, her condition rapidly improved. [Extracted from the article]

A 52-year-old woman experienced idiopathic intracranial hypertension (IH) while being treated with isotretinoin for rosacea. She later had a recurrence of IH while taking doxycycline for the same condition. The woman initially presented with bilateral papilledema and severe headaches, and further tests revealed radiographic features of IH. Treatment with liquor drainage and acetazolamide led to improvement, but the IH recurred after the first lumbar puncture. A second episode occurred after starting doxycycline, but the woman experienced improvement after discontinuing the medication. [Extracted from the article]

A 55-year-old woman with Whipple's disease experienced a lack of efficacy during treatment with cotrimoxazole. She initially presented with weakness and diarrhea and was diagnosed with Whipple's disease. After receiving long-term antibiotic therapy with ceftriaxone and then cotrimoxazole, she experienced a recurrence of symptoms. The woman was then switched to second-line therapy with doxycycline and hydroxychloroquine, which led to clinical improvement. After one year of treatment, she showed no symptoms of Whipple's disease. [Extracted from the article]

A study conducted at the All India Institute of Medical Sciences in New Delhi, India, found that a patient with human granulocytic anaplasmosis (HGA) did not respond to treatment with doxycycline. The patient experienced renal failure and severe complications related to HGA, ultimately resulting in death. The study concluded that doxycycline was ineffective in this case. [Extracted from the article]

A study conducted at the All India Institute of Medical Sciences in New Delhi, India, observed a patient with human granulocytic anaplasmosis (HGA) who did not respond to treatment with doxycycline. The patient experienced renal failure and severe complications related to HGA, ultimately resulting in death. The study concluded that doxycycline was ineffective in this case. [Extracted from the article]

A 25-year-old man with cerebral palsy and ventilator dependence developed a chest wall infection. He was initially treated with doxycycline, but after three days, the infection worsened, indicating a lack of efficacy. He was then evaluated in the emergency department and started on different antibiotics. The infection was found to be caused by P. aeruginosa, C. koseri, and Stenotrophomonas maltophilia. With the appropriate antibiotics and wound debridement, the man's condition improved, and he was discharged from the hospital. [Extracted from the article]

A 72-year-old man with a history of hyperlipidemia and hypertension was diagnosed with Lyme disease and started on a 10-day course of oral doxycycline. However, despite treatment, he experienced a lack of efficacy and presented with cardiac arrest, ventricular tachycardia, and ventricular fibrillation. He was successfully resuscitated and treated with various medications, including amiodarone and lidocaine. Further investigations revealed coronary artery disease, and he underwent stent placement and intra-aortic balloon pump placement. It was determined that he had Lyme myocarditis, which presented unusually with these cardiac complications. [Extracted from the article]

A systematic retrospective review study of 341 patients found that a patient with multiple myeloma and who underwent autologous stem cell transplant (ASCT) experienced a lack of efficacy during treatment with doxycycline and unspecified fluoroquinolones for bacterial prophylaxis. Despite receiving these treatments, the patient developed staphylococcus epidermidis. The study did not provide specific information about the patient's age, sex, dosages, or routes of administration for the medications. [Extracted from the article]

A 62-year-old man experienced a lack of efficacy during treatment with doxycycline for anaplasma phagocytophilum. The man presented with symptoms such as malaise, headache, and fever after being bitten by ticks. He was diagnosed with anaplasma phagocytophilum and received treatment with oral doxycycline. However, he later developed neurological symptoms and was hospitalized. After further treatment with IV doxycycline and IV ceftriaxone, his condition improved and he recovered. The case suggests a potential post-infectious mechanism for the neurological symptoms. [Extracted from the article]

A 36-year-old man experienced a lack of efficacy during treatment for a Brucella melitensis infection. He was initially treated with vancomycin and piperacillin/tazobactam, but later switched to ceftriaxone, doxycycline, and rifampicin. Despite continued treatment, the man developed complications including ataxia, strokes, and polyneuropathy, suggesting that the antibiotics were not effective. It was discovered that the symptoms developed after the man consumed unpasteurized cheese. [Extracted from the article]

A 36-year-old woman with hypothyroidism and systemic sclerosis exhibited lack of efficacy during treatment with clindamycin, doxycycline, and azithromycin. She presented to the hospital with ventricular tachycardia and supraventricular tachycardia and was admitted. Despite receiving treatment, she developed cardiac manifestations of progressive systemic sclerosis, indicating lack of efficacy. She was started on mycophenolate as an immunosuppressive agent and discharged. On follow-up, she continued conservative management with homeopathic intervention and did not experience a recurrence of tachycardia. [Extracted from the article]

A 7-year-old boy experienced various toxicities and lack of efficacy during treatment for Lyme disease. He developed blurry vision, color blindness, and intracranial hypertension while taking doxycycline, and also experienced electrolyte imbalances while taking acetazolamide. The boy's symptoms worsened despite treatment with acetazolamide and methylprednisolone, and he required a temporary lumbar drain for relief. Although his vision improved over time, he was ultimately declared legally blind due to severe peripheral visual field restriction. [Extracted from the article]

A 59-year-old man developed acute renal failure (ARF) while being treated for brucellosis with rifampicin, gentamicin, and doxycycline. The patient had a history of knee joint pain and knee replacement surgery. He experienced symptoms such as anuria, nausea, and vomiting, and his kidney function tests showed abnormalities. He was admitted to the hospital and underwent hemodialysis. After a change in his anti-brucella treatment and a week of treatment, his renal function gradually improved, and he was discharged. Follow-up tests showed further improvement in his kidney function. [Extracted from the article]

A 44-year-old man with a medical history of diabetes experienced a lack of efficacy during treatment with doxycycline and prednisone for rickettsia and rituximab for leukocytoclastic vasculitis. He presented to the emergency department with abdominal pain and a purpuric rash on his extremities, and subsequently had seizures and cardiac arrest. Despite interventions, including cardiopulmonary resuscitation, his condition worsened and he died of cardiac arrest. The lack of efficacy of the medications was noted in his case. [Extracted from the article]

A 40-year-old man experienced lack of efficacy during off-label treatment with dexamethasone and doxycycline for SARS-CoV-2 infection. The man, who was obese, presented with symptoms including nausea, vomiting, shortness of breath, and cough. He was also diagnosed with hypocalcemia, newly diagnosed type 2 diabetes mellitus, and primary hypothyroidism. Treatment with calcium-gluconate improved his hypocalcemia after his respiratory symptoms improved. [Extracted from the article]

A case series involving seven patients (two boys and five girls) aged 7-10 years with melioidosis due to Burkholderia pseudomallei infection was examined. The patients developed various toxicities while being treated with cotrimoxazole or doxycycline. These toxicities included rash, nausea and vomiting, neutropenia, lip swelling, and photosensitivity. The patients' antibiotic therapies were adjusted or discontinued based on the observed toxicities, and alternative treatments were administered. The toxicities resolved in all patients, and their conditions improved with appropriate treatment. [Extracted from the article]

A 42-year-old man with a history of Wolf Parkinson White syndrome (WPW) experienced a lack of efficacy during treatment with doxycycline for Lyme disease and adenosine for supraventricular tachycardia (SVT). Despite ongoing doxycycline, his palpitations persisted, leading him to seek treatment at the emergency department. He was diagnosed with SVT and received IV adenosine, but there was no resolution of his symptoms. He ultimately underwent cardioversion and was started on procainamide. Due to the presumed cause of his symptoms being Lyme disease, his doxycycline was replaced with ceftriaxone. [Extracted from the article]

A 55-year-old woman experienced various adverse reactions during her treatment for pulmonary lesions and brain lesions. She developed immunosuppression from dexamethasone, gastric intolerance from doxycycline, and pancytopenia from cotrimoxazole. The woman also had COVID-19 and was hospitalized due to pancytopenia. Her disseminated nocardiosis was resolving with the use of ceftriaxone and minocycline. [Extracted from the article]

A 72-year-old man with a Borrelia afzelii infection experienced a lack of efficacy with ciprofloxacin and doxycycline treatment. He developed a sudden fever and sought medical attention after being bitten by a tick at a deer farm. Despite receiving ciprofloxacin and doxycycline, he died three days after starting the doxycycline treatment. Molecular diagnostic tests confirmed the presence of B. afzelii in his blood, and mutations were discovered. The lack of efficacy of ciprofloxacin and doxycycline in treating the B. afzelii infection was considered a contributing factor to his death. [Extracted from the article]

A 44-year-old man with a history of substance abuse, cirrhosis, and recent oyster consumption presented to the emergency department with leg pain, rash, and fever. His condition rapidly deteriorated, leading to large bullae with necrosis, septic shock, and multi-system organ failure. Despite aggressive treatment including surgery and the administration of ceftazidime, doxycycline, and vancomycin, the patient's condition continued to decline, and he ultimately died from Vibrio vulnificus infection. This case highlights the lack of efficacy of the antibiotics used in this particular case. [Extracted from the article]

A case study published in Reactions Weekly describes a 70-year-old man who experienced a lack of efficacy while being treated with doxycycline for scrub typhus. The man was admitted to the hospital with fever and abdominal pain and was diagnosed with scrub typhus, as well as liver injury and intracranial infection. Despite receiving doxycycline, his condition worsened and he developed loss of consciousness and limb convulsions. He was transferred to the ICU and treated with moxifloxacin, which led to improvement in his symptoms. Eventually, he recovered and was discharged from the hospital. [Extracted from the article]

A 15-year-old boy with Crohn's disease developed blepharitis while being treated with adalimumab and golimumab. He also experienced lack of efficacy when treated with doxycycline for the blepharitis. The boy's symptoms improved when he was switched to amoxicillin/clavulanic acid and later ustekinumab. His digestive, rheumatological, and dermatological symptoms were controlled, and he was able to taper off prednisone. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA 61-year-old man developed bullous pemphigoid following treatment with imatinib for chronic myeloid leukaemia. Additionally, he exhibited lack of efficacy during treatment with doxycycline and clobetasol for bullous pemphigoid. [Extracted from the article]

A 14-year-old boy with febrile ulceronecrotic mucha-habermann disease (FUMHD) exhibited a lack of efficacy during treatment with doxycycline. The boy presented with fever, fatigue, headache, and necrotic papules and plaques on his upper back. Despite receiving doxycycline, his fevers did not improve. He was subsequently treated with methylprednisolone, which led to improvement in his fever and skin findings. After being switched to prednisolone, the boy was discharged from the hospital and his skin lesions resolved at a 6-week follow-up. [Extracted from the article]

Author InformationAn event is serious (based on the ICH definition) when the patient outcome is:• * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important eventA 16-year-old girl exhibited lack of efficacy during treatment with amoxicillin/clavulanic-acid, clarithromycin, ciprofloxacin and doxycycline for Streptococcus dysgalactiae-associated abscessed pneumonia [routes and dosages not stated]. [Extracted from the article]

A 76-year-old man experienced hepatotoxicity while being treated with methotrexate for bullous pemphigoid and Sezary syndrome. He also did not respond well to doxycycline and prednisone for bullous pemphigoid. Methotrexate was discontinued due to the hepatotoxicity, and the man was then treated with doxycycline, which was ineffective. He was subsequently given prednisone for 6 months, which initially controlled the skin disease, but as the dose was decreased, the bullous pemphigoid relapsed. He was then treated with vorinostat and unspecified corticosteroids, which significantly improved his condition. The bullous pemphigoid resolved completely and reached full remission, while the Sezary syndrome remained stable. [Extracted from the article]

This article presents three case reports of patients who experienced adverse reactions during treatment with abatacept, doxycycline, and methotrexate. One patient developed a Mycobacterium haemophilum infection, another patient developed a photosensitivity reaction to doxycycline, and the third patient developed a Mycobacterium haemophilum infection while on methotrexate and abatacept. The patients' symptoms and treatment outcomes are described in detail. These case reports highlight the importance of monitoring patients for potential adverse reactions during treatment with these medications. [Extracted from the article]

A case report published in Reactions Weekly describes a 14-year-old boy who developed toxic epidermal necrolysis (TEN) while being treated with doxycycline for an upper respiratory tract infection. The boy experienced multiple skin lesions, pain, redness of the eye, and difficulty swallowing. He was diagnosed with TEN secondary to doxycycline and received treatment with antibiotics, corticosteroids, IV fluids, and topical agents. The boy eventually recovered from the condition. [Extracted from the article]